Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Des Moines to Prague from $382

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Scandinavian Airlines Logo
2:15 pm - 9:40 am
DSM
-
PRG
36h 25m
2 stops
Scandinavian Airlines Logo
3:20 pm - 10:26 pm
PRG
-
DSM
38h 06m
2 stops
$621Scandinavian Airlines
Mon, Aug 17 - Wed, Aug 26
American Airlines Logo
6:00 am - 8:15 am
DSM
-
PRG
19h 15m
1 stop
American Airlines Logo
10:15 am - 11:55 pm
PRG
-
DSM
20h 40m
1 stop
$714American Airlines
Mon, Aug 17 - Wed, Aug 26
Lufthansa Logo
11:40 am - 9:20 pm
DSM
-
PRG
26h 40m
2 stops
Lufthansa Logo
2:20 pm - 11:24 pm
PRG
-
DSM
16h 04m
2 stops
$716Lufthansa
Tue, May 5 - Tue, May 12
American Airlines Logo
9:00 am - 8:15 am
DSM
-
PRG
16h 15m
2 stops
American Airlines Logo
10:15 am - 11:55 pm
PRG
-
DSM
20h 40m
1 stop
$719American Airlines
Mon, Aug 17 - Wed, Aug 26
United Airlines Logo
6:20 am - 12:45 pm
DSM
-
PRG
23h 25m
2 stops
United Airlines Logo
11:40 am - 10:45 pm
PRG
-
DSM
18h 05m
2 stops
$729United Airlines
Tue, Apr 28 - Tue, May 5
Multiple Airlines Logo
8:30 pm - 10:50 am
DSM
-
PRG
31h 20m
2 stops
Multiple Airlines Logo
9:35 am - 7:24 pm
PRG
-
DSM
16h 49m
3 stops
$740Multiple Airlines
Mon, Aug 17 - Wed, Aug 26
Air Canada Logo
8:00 am - 8:30 am
DSM
-
PRG
17h 30m
3 stops
Air Canada Logo
11:40 am - 11:24 pm
PRG
-
DSM
18h 44m
3 stops
$753Air Canada
Tue, May 5 - Tue, May 12
Multiple Airlines Logo
11:09 am - 6:45 pm
DSM
-
PRG
24h 36m
2 stops
Multiple Airlines Logo
8:40 am - 10:26 am
PRG
-
DSM
32h 46m
2 stops
$767Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
5:44 am - 6:45 pm
DSM
-
PRG
30h 01m
2 stops
Multiple Airlines Logo
8:40 am - 11:49 pm
PRG
-
DSM
22h 09m
2 stops
$772Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
11:09 am - 6:45 pm
DSM
-
PRG
24h 36m
2 stops
Multiple Airlines Logo
8:40 am - 10:26 am
PRG
-
DSM
32h 46m
2 stops
$773Multiple Airlines
Wed, Apr 15 - Wed, Apr 22

United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Apr 28
DSM6:20 amDes Moines
23h 25m
2 stops
PRG12:45 pmVáclav Havel Prague
May 5
PRG11:40 amVáclav Havel Prague
18h 05m
2 stops
DSM10:45 pmDes Moines
$729
United Airlines
Apr 16
DSM6:20 amDes Moines
28h 35m
2 stops
PRG5:55 pmVáclav Havel Prague
Apr 23
PRG6:50 amVáclav Havel Prague
21h 42m
2 stops
DSM9:32 pmDes Moines
$831
United Airlines
Apr 17
DSM11:25 amDes Moines
23h 25m
2 stops
PRG5:50 pmVáclav Havel Prague
Apr 24
PRG6:50 amVáclav Havel Prague
18h 25m
2 stops
DSM6:15 pmDes Moines
$843

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
May 5
DSM8:00 amDes Moines
17h 30m
3 stops
PRG8:30 amVáclav Havel Prague
May 12
PRG11:40 amVáclav Havel Prague
18h 44m
3 stops
DSM11:24 pmDes Moines
$753
Air Canada
Apr 28
DSM1:10 pmDes Moines
16h 35m
3 stops
PRG12:45 pmVáclav Havel Prague
May 5
PRG11:40 amVáclav Havel Prague
18h 44m
3 stops
DSM11:24 pmDes Moines
$936
Air Canada
Apr 21
DSM1:10 pmDes Moines
16h 35m
3 stops
PRG12:45 pmVáclav Havel Prague
Apr 28
PRG11:40 amVáclav Havel Prague
18h 37m
3 stops
DSM11:17 pmDes Moines
$1,116

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/17

2:15 pm-9:40 am

2 stops36h 25m

Václav Havel Prague

Wed 8/26

3:20 pm-10:26 pm

2 stops38h 06m

$621

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/17

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Wed 8/26

10:15 am-11:55 pm

1 stop20h 40m

$714

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 5/5

11:40 am-9:20 pm

2 stops26h 40m

Václav Havel Prague

Tue 5/12

2:20 pm-11:24 pm

2 stops16h 04m

$716

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/17

9:00 am-8:15 am

2 stops16h 15m

Václav Havel Prague

Wed 8/26

10:15 am-11:55 pm

1 stop20h 40m

$719

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 4/28

6:20 am-12:45 pm

2 stops23h 25m

Václav Havel Prague

Tue 5/5

11:40 am-10:45 pm

2 stops18h 05m

$729

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/17

8:30 pm-10:50 am

2 stops31h 20m

Václav Havel Prague

Wed 8/26

9:35 am-7:24 pm

3 stops16h 49m

$740

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 5/5

8:00 am-8:30 am

3 stops17h 30m

Václav Havel Prague

Tue 5/12

11:40 am-11:24 pm

3 stops18h 44m

$753

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/15

11:09 am-6:45 pm

2 stops24h 36m

Václav Havel Prague

Wed 4/22

8:40 am-10:26 am

2 stops32h 46m

$767

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/15

5:44 am-6:45 pm

2 stops30h 01m

Václav Havel Prague

Wed 4/22

8:40 am-11:49 pm

2 stops22h 09m

$772

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/15

11:09 am-6:45 pm

2 stops24h 36m

Václav Havel Prague

Wed 4/22

8:40 am-10:26 am

2 stops32h 46m

$773

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 46% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

21h 35m

Direct flights

None
The fastest flight from Des Moines to Prague takes 21h 35m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 21h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Prague trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 4/3
Fri 4/10
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the Czech Republic

Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837