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Cheap flights from Des Moines to Prague from $324

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
11:23 am - 5:30 pm
DSM
-
PRG
23h 07m
2 stops
Lufthansa Logo
1:25 pm - 10:51 pm
PRG
-
DSM
16h 26m
2 stops
$970Lufthansa
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
11:23 am - 5:30 pm
DSM
-
PRG
23h 07m
2 stops
Lufthansa Logo
6:15 am - 10:51 pm
PRG
-
DSM
23h 36m
2 stops
$985Lufthansa
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
6:50 pm - 4:05 pm
DSM
-
PRG
14h 15m
2 stops
Lufthansa Logo
6:15 am - 6:13 pm
PRG
-
DSM
18h 58m
2 stops
$986Lufthansa
Fri, Jul 3 - Fri, Jul 10
Multiple Airlines Logo
1:40 pm - 5:30 pm
DSM
-
PRG
20h 50m
2 stops
Multiple Airlines Logo
6:15 am - 10:51 pm
PRG
-
DSM
23h 36m
2 stops
$1,012Multiple Airlines
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
6:50 pm - 11:00 am
DSM
-
PRG
33h 10m
2 stops
Lufthansa Logo
6:15 am - 10:51 pm
PRG
-
DSM
23h 36m
2 stops
$1,038Lufthansa
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
6:50 pm - 4:05 pm
DSM
-
PRG
14h 15m
2 stops
Lufthansa Logo
6:15 am - 6:13 pm
PRG
-
DSM
18h 58m
2 stops
$1,046Lufthansa
Fri, Jul 3 - Fri, Jul 10
Lufthansa Logo
11:23 am - 4:05 pm
DSM
-
PRG
21h 42m
2 stops
Lufthansa Logo
6:15 am - 11:44 pm
PRG
-
DSM
24h 29m
2 stops
$1,047Lufthansa
Thu, Jul 2 - Thu, Jul 9
United Airlines Logo
3:24 pm - 12:45 pm
DSM
-
PRG
14h 21m
2 stops
United Airlines Logo
9:35 am - 7:25 pm
PRG
-
DSM
16h 50m
2 stops
$1,049United Airlines
Thu, Jul 2 - Thu, Jul 9
KLM Logo
10:54 am - 8:20 am
DSM
-
PRG
14h 26m
2 stops
KLM Logo
11:15 am - 8:49 pm
PRG
-
DSM
16h 34m
2 stops
$1,050KLM
Wed, Jul 1 - Wed, Jul 8
KLM Logo
10:54 am - 8:20 am
DSM
-
PRG
14h 26m
2 stops
KLM Logo
11:15 am - 8:49 pm
PRG
-
DSM
16h 34m
2 stops
$1,052KLM
Wed, Jul 1 - Wed, Jul 8

United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Jul 2
DSM3:24 pmDes Moines
14h 21m
2 stops
PRG12:45 pmVáclav Havel Prague
Jul 9
PRG9:35 amVáclav Havel Prague
16h 50m
2 stops
DSM7:25 pmDes Moines
$1,049
United Airlines
Jul 2
DSM6:00 amDes Moines
23h 45m
3 stops
PRG12:45 pmVáclav Havel Prague
Jul 9
PRG9:35 amVáclav Havel Prague
15h 37m
2 stops
DSM6:12 pmDes Moines
$1,070
United Airlines
Jun 15
DSM6:50 pmDes Moines
19h 30m
2 stops
PRG9:20 pmVáclav Havel Prague
Jun 21
PRG12:30 pmVáclav Havel Prague
41h 21m
2 stops
DSM10:51 pmDes Moines
$1,224

American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Jul 2
DSM6:02 amDes Moines
19h 13m
1 stop
PRG8:15 amVáclav Havel Prague
Jul 9
PRG8:40 amVáclav Havel Prague
16h 53m
2 stops
DSM6:33 pmDes Moines
$1,141
American Airlines
Jul 3
DSM6:02 amDes Moines
19h 13m
1 stop
PRG8:15 amVáclav Havel Prague
Jul 10
PRG7:05 amVáclav Havel Prague
17h 58m
2 stops
DSM6:03 pmDes Moines
$1,154
American Airlines
Jun 30
DSM6:02 amDes Moines
19h 13m
1 stop
PRG8:15 amVáclav Havel Prague
Jul 7
PRG6:35 amVáclav Havel Prague
18h 28m
2 stops
DSM6:03 pmDes Moines
$1,166

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 19, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

11:23 am-5:30 pm

2 stops23h 07m

Václav Havel Prague

Wed 7/8

1:25 pm-10:51 pm

2 stops16h 26m

$970

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

11:23 am-5:30 pm

2 stops23h 07m

Václav Havel Prague

Wed 7/8

6:15 am-10:51 pm

2 stops23h 36m

$985

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 7/3

6:50 pm-4:05 pm

2 stops14h 15m

Václav Havel Prague

Fri 7/10

6:15 am-6:13 pm

2 stops18h 58m

$986

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

1:40 pm-5:30 pm

2 stops20h 50m

Václav Havel Prague

Wed 7/8

6:15 am-10:51 pm

2 stops23h 36m

$1,012

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

6:50 pm-11:00 am

2 stops33h 10m

Václav Havel Prague

Wed 7/8

6:15 am-10:51 pm

2 stops23h 36m

$1,038

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 7/3

6:50 pm-4:05 pm

2 stops14h 15m

Václav Havel Prague

Fri 7/10

6:15 am-6:13 pm

2 stops18h 58m

$1,046

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 7/2

11:23 am-4:05 pm

2 stops21h 42m

Václav Havel Prague

Thu 7/9

6:15 am-11:44 pm

2 stops24h 29m

$1,047

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 7/2

3:24 pm-12:45 pm

2 stops14h 21m

Václav Havel Prague

Thu 7/9

9:35 am-7:25 pm

2 stops16h 50m

$1,049
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

10:54 am-8:20 am

2 stops14h 26m

Václav Havel Prague

Wed 7/8

11:15 am-8:49 pm

2 stops16h 34m

$1,050

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/1

10:54 am-8:20 am

2 stops14h 26m

Václav Havel Prague

Wed 7/8

11:15 am-8:49 pm

2 stops16h 34m

$1,052

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 6% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

12h 42m

Direct flights

None
The fastest flight from Des Moines to Prague takes 12h 42m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 12h 42m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Find better results for your trip to the Czech Republic

Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837