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Cheap flights from Des Moines to Prague from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:30 pm - 3:00 pm
DSM
-
PRG
14h 30m
2 stops
Delta Logo
2:30 pm - 2:06 pm
PRG
-
DSM
30h 36m
2 stops
$851Delta
Mon, Sep 7 - Mon, Sep 14
Lufthansa Logo
1:21 pm - 8:55 am
DSM
-
PRG
12h 34m
2 stops
Lufthansa Logo
4:40 pm - 9:28 pm
PRG
-
DSM
35h 48m
2 stops
$864Lufthansa
Sun, Sep 6 - Sun, Sep 13
Multiple Airlines Logo
6:55 pm - 4:00 pm
DSM
-
PRG
14h 05m
2 stops
Multiple Airlines Logo
12:30 pm - 11:35 pm
PRG
-
DSM
42h 05m
2 stops
$874Multiple Airlines
Sun, Oct 4 - Wed, Oct 14
Lufthansa Logo
3:20 pm - 8:55 am
DSM
-
PRG
34h 35m
2 stops
Lufthansa Logo
4:40 pm - 9:28 pm
PRG
-
DSM
35h 48m
2 stops
$879Lufthansa
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 12:31 pm
PRG
-
DSM
33h 16m
1 stop
$881American Airlines
Fri, Sep 4 - Fri, Sep 11
American Airlines Logo
1:55 pm - 1:35 pm
DSM
-
PRG
16h 40m
2 stops
American Airlines Logo
10:15 am - 12:31 pm
PRG
-
DSM
33h 16m
1 stop
$886American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
1:30 pm - 1:35 pm
DSM
-
PRG
17h 05m
2 stops
American Airlines Logo
10:15 am - 12:31 pm
PRG
-
DSM
33h 16m
1 stop
$887American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$889American Airlines
Fri, Sep 4 - Fri, Sep 11
American Airlines Logo
12:52 pm - 8:15 am
DSM
-
PRG
12h 23m
1 stop
American Airlines Logo
10:15 am - 12:31 pm
PRG
-
DSM
33h 16m
1 stop
$891American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$892American Airlines
Fri, Sep 4 - Fri, Sep 11

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American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Sep 4
DSM5:40 amDes Moines
19h 35m
1 stop
PRG8:15 amVáclav Havel Prague
Sep 11
PRG10:15 amVáclav Havel Prague
33h 16m
1 stop
DSM12:31 pmDes Moines
$881
American Airlines
Sep 6
DSM1:55 pmDes Moines
16h 40m
2 stops
PRG1:35 pmVáclav Havel Prague
Sep 13
PRG10:15 amVáclav Havel Prague
33h 16m
1 stop
DSM12:31 pmDes Moines
$886
American Airlines
Sep 6
DSM1:30 pmDes Moines
17h 05m
2 stops
PRG1:35 pmVáclav Havel Prague
Sep 13
PRG10:15 amVáclav Havel Prague
33h 16m
1 stop
DSM12:31 pmDes Moines
$887

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Sep 6
DSM1:21 pmDes Moines
12h 34m
2 stops
PRG8:55 amVáclav Havel Prague
Sep 13
PRG4:40 pmVáclav Havel Prague
35h 48m
2 stops
DSM9:28 pmDes Moines
$864
Lufthansa
Sep 5
DSM3:20 pmDes Moines
34h 35m
2 stops
PRG8:55 amVáclav Havel Prague
Sep 12
PRG4:40 pmVáclav Havel Prague
35h 48m
2 stops
DSM9:28 pmDes Moines
$879

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 9/7

5:30 pm-3:00 pm

2 stops14h 30m

Václav Havel Prague

Mon 9/14

2:30 pm-2:06 pm

2 stops30h 36m

$851

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 9/6

1:21 pm-8:55 am

2 stops12h 34m

Václav Havel Prague

Sun 9/13

4:40 pm-9:28 pm

2 stops35h 48m

$864

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 10/4

6:55 pm-4:00 pm

2 stops14h 05m

Václav Havel Prague

Wed 10/14

12:30 pm-11:35 pm

2 stops42h 05m

$874

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 9/5

3:20 pm-8:55 am

2 stops34h 35m

Václav Havel Prague

Sat 9/12

4:40 pm-9:28 pm

2 stops35h 48m

$879

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 9/4

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Fri 9/11

10:15 am-12:31 pm

1 stop33h 16m

$881

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 9/6

1:55 pm-1:35 pm

2 stops16h 40m

Václav Havel Prague

Sun 9/13

10:15 am-12:31 pm

1 stop33h 16m

$886

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 9/6

1:30 pm-1:35 pm

2 stops17h 05m

Václav Havel Prague

Sun 9/13

10:15 am-12:31 pm

1 stop33h 16m

$887
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 9/4

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Fri 9/11

10:15 am-9:36 pm

1 stop18h 21m

$889

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 9/6

12:52 pm-8:15 am

1 stop12h 23m

Václav Havel Prague

Sun 9/13

10:15 am-12:31 pm

1 stop33h 16m

$891

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 9/4

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Fri 9/11

10:15 am-9:36 pm

1 stop18h 21m

$892

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

12h 34m

Direct flights

None
The fastest flight from Des Moines to Prague takes 12h 34m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 12h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588