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Cheap flights from Des Moines to Prague from $387

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
5:16 pm - 10:50 am
DSM
-
PRG
58h 34m
2 stops
Air Canada Logo
12:30 pm - 5:02 pm
PRG
-
DSM
35h 32m
2 stops
$774Air Canada
Fri, Aug 14 - Mon, Aug 24
United Airlines Logo
1:05 pm - 12:45 pm
DSM
-
PRG
16h 40m
2 stops
United Airlines Logo
1:25 pm - 5:02 pm
PRG
-
DSM
34h 37m
2 stops
$809United Airlines
Mon, Aug 10 - Mon, Aug 17
American Airlines Logo
5:10 pm - 4:50 pm
DSM
-
PRG
16h 40m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$823American Airlines
Fri, Aug 14 - Mon, Aug 24
American Airlines Logo
1:12 pm - 8:15 am
DSM
-
PRG
12h 03m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$826American Airlines
Fri, Aug 14 - Mon, Aug 24
American Airlines Logo
8:03 pm - 6:40 pm
DSM
-
PRG
15h 37m
2 stops
American Airlines Logo
10:15 am - 9:58 pm
PRG
-
DSM
18h 43m
1 stop
$831American Airlines
Sun, May 10 - Tue, May 26
American Airlines Logo
6:00 am - 8:15 am
DSM
-
PRG
19h 15m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$832American Airlines
Thu, Aug 27 - Tue, Sep 8
American Airlines Logo
8:03 pm - 6:40 pm
DSM
-
PRG
15h 37m
2 stops
American Airlines Logo
10:15 am - 12:17 am
PRG
-
DSM
21h 02m
2 stops
$836American Airlines
Sun, May 10 - Tue, May 26
American Airlines Logo
3:41 pm - 3:45 pm
DSM
-
PRG
17h 04m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$839American Airlines
Wed, Aug 19 - Sat, Aug 29
American Airlines Logo
6:00 am - 8:15 am
DSM
-
PRG
19h 15m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$842American Airlines
Wed, Aug 19 - Sat, Aug 29
American Airlines Logo
1:08 pm - 1:15 pm
DSM
-
PRG
17h 07m
2 stops
American Airlines Logo
10:15 am - 8:45 pm
PRG
-
DSM
17h 30m
2 stops
$843American Airlines
Wed, Aug 19 - Sat, Aug 29

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American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Aug 14
DSM5:10 pmDes Moines
16h 40m
2 stops
PRG4:50 pmVáclav Havel Prague
Aug 24
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$823
American Airlines
Aug 14
DSM1:12 pmDes Moines
12h 03m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 24
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$826
American Airlines
May 10
DSM8:03 pmDes Moines
15h 37m
2 stops
PRG6:40 pmVáclav Havel Prague
May 26
PRG10:15 amVáclav Havel Prague
18h 43m
1 stop
DSM9:58 pmDes Moines
$831

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Aug 14
DSM5:16 pmDes Moines
58h 34m
2 stops
PRG10:50 amVáclav Havel Prague
Aug 24
PRG12:30 pmVáclav Havel Prague
35h 32m
2 stops
DSM5:02 pmDes Moines
$774
Air Canada
Sep 4
DSM8:30 pmDes Moines
55h 20m
2 stops
PRG10:50 amVáclav Havel Prague
Sep 12
PRG12:30 pmVáclav Havel Prague
29h 20m
2 stops
DSM10:50 amDes Moines
$864
Air Canada
Aug 27
DSM11:23 amDes Moines
16h 37m
3 stops
PRG11:00 amVáclav Havel Prague
Sep 8
PRG2:20 pmVáclav Havel Prague
17h 14m
3 stops
DSM12:34 amDes Moines
$1,002

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

5:16 pm-10:50 am

2 stops58h 34m

Václav Havel Prague

Mon 8/24

12:30 pm-5:02 pm

2 stops35h 32m

$774

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/10

1:05 pm-12:45 pm

2 stops16h 40m

Václav Havel Prague

Mon 8/17

1:25 pm-5:02 pm

2 stops34h 37m

$809

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

5:10 pm-4:50 pm

2 stops16h 40m

Václav Havel Prague

Mon 8/24

10:15 am-10:06 pm

1 stop18h 51m

$823
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

1:12 pm-8:15 am

1 stop12h 03m

Václav Havel Prague

Mon 8/24

10:15 am-10:06 pm

1 stop18h 51m

$826

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 5/10

8:03 pm-6:40 pm

2 stops15h 37m

Václav Havel Prague

Tue 5/26

10:15 am-9:58 pm

1 stop18h 43m

$831

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/27

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Tue 9/8

10:15 am-10:06 pm

1 stop18h 51m

$832

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 5/10

8:03 pm-6:40 pm

2 stops15h 37m

Václav Havel Prague

Tue 5/26

10:15 am-12:17 am

2 stops21h 02m

$836

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

3:41 pm-3:45 pm

2 stops17h 04m

Václav Havel Prague

Sat 8/29

10:15 am-10:06 pm

1 stop18h 51m

$839

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Sat 8/29

10:15 am-10:06 pm

1 stop18h 51m

$842

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

1:08 pm-1:15 pm

2 stops17h 07m

Václav Havel Prague

Sat 8/29

10:15 am-8:45 pm

2 stops17h 30m

$843

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 32% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

16h 40m

Direct flights

None
The fastest flight from Des Moines to Prague takes 16h 40m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 40m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837