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Cheap flights from Des Moines to Prague from $267

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 5/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
KLM Logo
5:47 pm - 5:35 pm
DSM
-
PRG
17h 48m
2 stops
KLM Logo
6:30 pm - 4:54 pm
PRG
-
DSM
28h 24m
2 stops
$508KLM
Mon, Mar 9 - Mon, Mar 16
British Airways Logo
5:00 pm - 4:50 pm
DSM
-
PRG
16h 50m
2 stops
British Airways Logo
6:50 am - 7:31 pm
PRG
-
DSM
19h 41m
2 stops
$595British Airways
Fri, May 1 - Sun, May 10
British Airways Logo
5:00 pm - 7:10 pm
DSM
-
PRG
19h 10m
2 stops
British Airways Logo
9:20 pm - 11:29 pm
PRG
-
DSM
33h 09m
2 stops
$597British Airways
Fri, May 1 - Sun, May 10
Multiple Airlines Logo
12:25 pm - 11:40 am
DSM
-
PRG
16h 15m
2 stops
Multiple Airlines Logo
6:00 am - 4:57 pm
PRG
-
DSM
17h 57m
2 stops
$710Multiple Airlines
Tue, Feb 17 - Sat, Feb 28
United Airlines Logo
7:00 am - 10:25 pm
DSM
-
PRG
33h 25m
2 stops
United Airlines Logo
1:45 pm - 2:18 pm
PRG
-
DSM
54h 33m
2 stops
$825United Airlines
Sun, Mar 15 - Sun, Mar 22
United Airlines Logo
6:49 pm - 4:05 pm
DSM
-
PRG
39h 16m
2 stops
United Airlines Logo
1:45 pm - 4:07 pm
PRG
-
DSM
56h 22m
3 stops
$940United Airlines
Sun, Mar 15 - Sun, Mar 22
Air Canada Logo
8:00 am - 8:30 am
DSM
-
PRG
17h 30m
3 stops
Air Canada Logo
9:35 am - 9:18 pm
PRG
-
DSM
18h 43m
3 stops
$1,000Air Canada
Fri, May 1 - Sun, May 10
Air Canada Logo
11:40 am - 11:05 am
DSM
-
PRG
16h 25m
3 stops
Air Canada Logo
9:35 am - 9:18 pm
PRG
-
DSM
18h 43m
3 stops
$1,056Air Canada
Fri, May 1 - Sun, May 10
United Airlines Logo
6:49 pm - 10:50 am
DSM
-
PRG
34h 01m
2 stops
United Airlines Logo
1:45 pm - 9:40 pm
PRG
-
DSM
37h 55m
2 stops
$1,129United Airlines
Sat, Mar 14 - Sat, Mar 21
United Airlines Logo
6:49 pm - 11:10 am
DSM
-
PRG
34h 21m
2 stops
United Airlines Logo
1:45 pm - 6:08 pm
PRG
-
DSM
34h 23m
2 stops
$1,136United Airlines
Sat, Mar 14 - Sat, Mar 21

United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Mar 15
DSM7:00 amDes Moines
33h 25m
2 stops
PRG10:25 pmVáclav Havel Prague
Mar 22
PRG1:45 pmVáclav Havel Prague
54h 33m
2 stops
DSM2:18 pmDes Moines
$825
United Airlines
Mar 15
DSM6:49 pmDes Moines
39h 16m
2 stops
PRG4:05 pmVáclav Havel Prague
Mar 22
PRG1:45 pmVáclav Havel Prague
56h 22m
3 stops
DSM4:07 pmDes Moines
$940
United Airlines
Mar 14
DSM6:49 pmDes Moines
34h 01m
2 stops
PRG10:50 amVáclav Havel Prague
Mar 21
PRG1:45 pmVáclav Havel Prague
37h 55m
2 stops
DSM9:40 pmDes Moines
$1,129

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
May 1
DSM8:00 amDes Moines
17h 30m
3 stops
PRG8:30 amVáclav Havel Prague
May 10
PRG9:35 amVáclav Havel Prague
18h 43m
3 stops
DSM9:18 pmDes Moines
$1,000
Air Canada
May 1
DSM11:40 amDes Moines
16h 25m
3 stops
PRG11:05 amVáclav Havel Prague
May 10
PRG9:35 amVáclav Havel Prague
18h 43m
3 stops
DSM9:18 pmDes Moines
$1,056
Air Canada
Feb 17
DSM11:30 amDes Moines
16h 55m
3 stops
PRG11:25 amVáclav Havel Prague
Feb 28
PRG7:35 amVáclav Havel Prague
17h 12m
3 stops
DSM5:47 pmDes Moines
$1,788

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 3/9

5:47 pm-5:35 pm

2 stops17h 48m

Václav Havel Prague

Mon 3/16

6:30 pm-4:54 pm

2 stops28h 24m

$508

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

5:00 pm-4:50 pm

2 stops16h 50m

Václav Havel Prague

Sun 5/10

6:50 am-7:31 pm

2 stops19h 41m

$595

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

5:00 pm-7:10 pm

2 stops19h 10m

Václav Havel Prague

Sun 5/10

9:20 pm-11:29 pm

2 stops33h 09m

$597

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/17

12:25 pm-11:40 am

2 stops16h 15m

Václav Havel Prague

Sat 2/28

6:00 am-4:57 pm

2 stops17h 57m

$710

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 3/15

7:00 am-10:25 pm

2 stops33h 25m

Václav Havel Prague

Sun 3/22

1:45 pm-2:18 pm

2 stops54h 33m

$825

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 3/15

6:49 pm-4:05 pm

2 stops39h 16m

Václav Havel Prague

Sun 3/22

1:45 pm-4:07 pm

3 stops56h 22m

$940

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

8:00 am-8:30 am

3 stops17h 30m

Václav Havel Prague

Sun 5/10

9:35 am-9:18 pm

3 stops18h 43m

$1,000

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

11:40 am-11:05 am

3 stops16h 25m

Václav Havel Prague

Sun 5/10

9:35 am-9:18 pm

3 stops18h 43m

$1,056

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 3/14

6:49 pm-10:50 am

2 stops34h 01m

Václav Havel Prague

Sat 3/21

1:45 pm-9:40 pm

2 stops37h 55m

$1,129

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 3/14

6:49 pm-11:10 am

2 stops34h 21m

Václav Havel Prague

Sat 3/21

1:45 pm-6:08 pm

2 stops34h 23m

$1,136

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

16h 15m

Direct flights

None
The fastest flight from Des Moines to Prague takes 16h 15m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Václav Havel Prague Airport?

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Prague?

Best airlines flying from Des Moines to Prague

Compare and see reviews for airlines that fly from Des Moines to Prague with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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