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Cheap flights from Des Moines to Prague from $325

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 3/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:48 pm - 10:25 pmDSM-PRG
20h 37m2 stops
Lufthansa Logo
7:35 am - 9:50 pmPRG-DSM
21h 15m2 stops
$416Lufthansa
Find Deal
Thu, Jan 8 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 1:05 pmDSM-PRG
35h 17m2 stops
Lufthansa Logo
10:15 am - 9:50 pmPRG-DSM
18h 35m2 stops
$458Lufthansa
Find Deal
Wed, Jan 7 - Wed, Jan 14
Lufthansa Logo
6:48 pm - 6:15 pmDSM-PRG
16h 27m2 stops
Lufthansa Logo
7:35 am - 9:50 pmPRG-DSM
21h 15m2 stops
$467Lufthansa
Find Deal
Fri, Jan 9 - Fri, Jan 16
Lufthansa Logo
6:48 pm - 6:05 pmDSM-PRG
16h 17m2 stops
Lufthansa Logo
10:15 am - 9:50 pmPRG-DSM
18h 35m2 stops
$472Lufthansa
Find Deal
Wed, Jan 7 - Wed, Jan 14
Lufthansa Logo
6:48 pm - 6:15 pmDSM-PRG
16h 27m2 stops
Lufthansa Logo
7:35 am - 9:50 pmPRG-DSM
21h 15m2 stops
$475Lufthansa
Find Deal
Fri, Jan 9 - Fri, Jan 16
Multiple Airlines Logo
3:35 pm - 5:55 pmDSM-PRG
19h 20m2 stops
Multiple Airlines Logo
10:25 am - 10:30 pmPRG-DSM
19h 05m2 stops
$477Multiple Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 10:25 pmDSM-PRG
20h 37m2 stops
Lufthansa Logo
10:25 am - 9:50 pmPRG-DSM
18h 25m2 stops
$484Lufthansa
Find Deal
Thu, Jan 8 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 10:25 pmDSM-PRG
20h 37m2 stops
Lufthansa Logo
7:30 am - 9:50 pmPRG-DSM
21h 20m2 stops
$494Lufthansa
Find Deal
Wed, Jan 7 - Wed, Jan 14
Lufthansa Logo
6:48 pm - 1:05 pmDSM-PRG
35h 17m2 stops
Lufthansa Logo
10:15 am - 9:50 pmPRG-DSM
18h 35m2 stops
$495Lufthansa
Find Deal
Wed, Jan 7 - Wed, Jan 14
Lufthansa Logo
6:48 pm - 10:25 pmDSM-PRG
20h 37m2 stops
Lufthansa Logo
7:35 am - 9:50 pmPRG-DSM
21h 15m2 stops
$496Lufthansa
Find Deal
Thu, Jan 8 - Thu, Jan 15

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Jan 7
DSM11:30 amDes Moines
19h 35m
3 stops
PRG2:05 pmVáclav Havel Prague
Jan 14
PRG7:30 amVáclav Havel Prague
21h 20m
3 stops
DSM9:50 pmDes Moines
$911
Find similar
Air Canada
Jan 7
DSM11:30 amDes Moines
19h 35m
3 stops
PRG2:05 pmVáclav Havel Prague
Jan 14
PRG7:30 amVáclav Havel Prague
21h 20m
3 stops
DSM9:50 pmDes Moines
$912
Find similar
Air Canada
Jan 7
DSM11:30 amDes Moines
19h 35m
3 stops
PRG2:05 pmVáclav Havel Prague
Jan 14
PRG7:30 amVáclav Havel Prague
21h 20m
3 stops
DSM9:50 pmDes Moines
$913
Find similar

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Jan 8
DSM6:48 pmDes Moines
20h 37m
2 stops
PRG10:25 pmVáclav Havel Prague
Jan 15
PRG7:35 amVáclav Havel Prague
21h 15m
2 stops
DSM9:50 pmDes Moines
$416
Find similar
Lufthansa
Jan 7
DSM6:48 pmDes Moines
35h 17m
2 stops
PRG1:05 pmVáclav Havel Prague
Jan 14
PRG10:15 amVáclav Havel Prague
18h 35m
2 stops
DSM9:50 pmDes Moines
$458
Find similar
Lufthansa
Jan 9
DSM6:48 pmDes Moines
16h 27m
2 stops
PRG6:15 pmVáclav Havel Prague
Jan 16
PRG7:35 amVáclav Havel Prague
21h 15m
2 stops
DSM9:50 pmDes Moines
$467
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 1/8

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

Thu 1/15

7:35 am-9:50 pm

2 stops21h 15m

$416

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 1/7

6:48 pm-1:05 pm

2 stops35h 17m

Václav Havel Prague

Wed 1/14

10:15 am-9:50 pm

2 stops18h 35m

$458

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 1/9

6:48 pm-6:15 pm

2 stops16h 27m

Václav Havel Prague

Fri 1/16

7:35 am-9:50 pm

2 stops21h 15m

$467

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 1/7

6:48 pm-6:05 pm

2 stops16h 17m

Václav Havel Prague

Wed 1/14

10:15 am-9:50 pm

2 stops18h 35m

$472

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 1/9

6:48 pm-6:15 pm

2 stops16h 27m

Václav Havel Prague

Fri 1/16

7:35 am-9:50 pm

2 stops21h 15m

$475

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 1/8

3:35 pm-5:55 pm

2 stops19h 20m

Václav Havel Prague

Thu 1/15

10:25 am-10:30 pm

2 stops19h 05m

$477

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 1/8

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

Thu 1/15

10:25 am-9:50 pm

2 stops18h 25m

$484

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 1/7

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

Wed 1/14

7:30 am-9:50 pm

2 stops21h 20m

$494

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 1/7

6:48 pm-1:05 pm

2 stops35h 17m

Václav Havel Prague

Wed 1/14

10:15 am-9:50 pm

2 stops18h 35m

$495

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 1/8

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

Thu 1/15

7:35 am-9:50 pm

2 stops21h 15m

$496

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Prague?

The cheapest day to depart from Des Moines to Prague is on a Tuesday. Travelers who choose to depart for Prague on a Tuesday will often find tickets for as low as $816. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Prague for around $1,811.

What is the cheapest time of day to depart on your flight to Prague?

According to our data, the cheapest time of day to fly to Prague is in the afternoon. momondo users have found flights departing from Des Moines to Prague in the afternoon for as low as $1,080. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $1,157. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

17h 30m

Direct flights

None
The fastest flight from Des Moines to Prague takes 17h 30m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Václav Havel Prague Airport?

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Prague?

Best airlines flying from Des Moines to Prague

Compare and see reviews for airlines that fly from Des Moines to Prague with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,044 reviews
Search United Airlines flights

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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