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Cheap flights from Des Moines to Prague from $330

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:36 pm - 6:40 pm
DSM
-
PRG
17h 04m
2 stops
American Airlines Logo
8:40 am - 9:44 pm
PRG
-
DSM
20h 04m
2 stops
$787American Airlines
Sun, Oct 11 - Tue, Oct 20
Multiple Airlines Logo
8:00 am - 10:50 am
DSM
-
PRG
19h 50m
2 stops
Multiple Airlines Logo
11:40 am - 11:01 pm
PRG
-
DSM
18h 21m
3 stops
$807Multiple Airlines
Sun, Oct 11 - Tue, Oct 20
United Airlines Logo
1:40 pm - 12:45 pm
DSM
-
PRG
16h 05m
2 stops
United Airlines Logo
12:30 pm - 5:02 pm
PRG
-
DSM
35h 32m
2 stops
$818United Airlines
Fri, Aug 14 - Sun, Aug 23
American Airlines Logo
1:12 pm - 8:15 am
DSM
-
PRG
12h 03m
1 stop
American Airlines Logo
10:40 am - 11:15 pm
PRG
-
DSM
19h 35m
2 stops
$845American Airlines
Fri, Aug 14 - Sun, Aug 23
American Airlines Logo
1:12 pm - 8:15 am
DSM
-
PRG
12h 03m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$956American Airlines
Fri, Aug 14 - Sun, Aug 23
United Airlines Logo
5:00 am - 5:55 pm
DSM
-
PRG
29h 55m
2 stops
United Airlines Logo
12:30 pm - 10:27 am
PRG
-
DSM
28h 57m
2 stops
$1,016United Airlines
Wed, Jun 3 - Wed, Jun 10
Air Canada Logo
5:17 pm - 10:50 am
DSM
-
PRG
58h 33m
2 stops
Air Canada Logo
12:30 pm - 10:27 am
PRG
-
DSM
28h 57m
2 stops
$1,017Air Canada
Wed, Jun 10 - Wed, Jun 17
American Airlines Logo
7:10 pm - 8:50 pm
DSM
-
PRG
18h 40m
2 stops
American Airlines Logo
10:15 am - 9:58 pm
PRG
-
DSM
18h 43m
1 stop
$1,019American Airlines
Wed, Jun 3 - Wed, Jun 10
Air Canada Logo
5:17 pm - 10:50 am
DSM
-
PRG
58h 33m
2 stops
Air Canada Logo
12:30 pm - 10:27 am
PRG
-
DSM
28h 57m
2 stops
$1,031Air Canada
Wed, Jun 10 - Wed, Jun 17
United Airlines Logo
6:00 am - 5:55 pm
DSM
-
PRG
28h 55m
2 stops
United Airlines Logo
6:10 am - 6:14 pm
PRG
-
DSM
19h 04m
2 stops
$1,039United Airlines
Wed, May 27 - Wed, Jun 3

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United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Aug 14
DSM1:40 pmDes Moines
16h 05m
2 stops
PRG12:45 pmVáclav Havel Prague
Aug 23
PRG12:30 pmVáclav Havel Prague
35h 32m
2 stops
DSM5:02 pmDes Moines
$818
United Airlines
May 1
DSM8:00 amDes Moines
17h 55m
2 stops
PRG8:55 amVáclav Havel Prague
May 10
PRG9:10 amVáclav Havel Prague
15h 55m
2 stops
DSM6:05 pmDes Moines
$991
United Airlines
Jun 3
DSM5:00 amDes Moines
29h 55m
2 stops
PRG5:55 pmVáclav Havel Prague
Jun 10
PRG12:30 pmVáclav Havel Prague
28h 57m
2 stops
DSM10:27 amDes Moines
$1,016

American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Oct 11
DSM6:36 pmDes Moines
17h 04m
2 stops
PRG6:40 pmVáclav Havel Prague
Oct 20
PRG8:40 amVáclav Havel Prague
20h 04m
2 stops
DSM9:44 pmDes Moines
$787
American Airlines
Aug 14
DSM1:12 pmDes Moines
12h 03m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 23
PRG10:40 amVáclav Havel Prague
19h 35m
2 stops
DSM11:15 pmDes Moines
$845
American Airlines
Aug 14
DSM1:12 pmDes Moines
12h 03m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 23
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$956

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 10/11

6:36 pm-6:40 pm

2 stops17h 04m

Václav Havel Prague

Tue 10/20

8:40 am-9:44 pm

2 stops20h 04m

$787

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 10/11

8:00 am-10:50 am

2 stops19h 50m

Václav Havel Prague

Tue 10/20

11:40 am-11:01 pm

3 stops18h 21m

$807

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

1:40 pm-12:45 pm

2 stops16h 05m

Václav Havel Prague

Sun 8/23

12:30 pm-5:02 pm

2 stops35h 32m

$818

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

1:12 pm-8:15 am

1 stop12h 03m

Václav Havel Prague

Sun 8/23

10:40 am-11:15 pm

2 stops19h 35m

$845
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

1:12 pm-8:15 am

1 stop12h 03m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$956

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 6/3

5:00 am-5:55 pm

2 stops29h 55m

Václav Havel Prague

Wed 6/10

12:30 pm-10:27 am

2 stops28h 57m

$1,016

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 6/10

5:17 pm-10:50 am

2 stops58h 33m

Václav Havel Prague

Wed 6/17

12:30 pm-10:27 am

2 stops28h 57m

$1,017

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 6/3

7:10 pm-8:50 pm

2 stops18h 40m

Václav Havel Prague

Wed 6/10

10:15 am-9:58 pm

1 stop18h 43m

$1,019

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 6/10

5:17 pm-10:50 am

2 stops58h 33m

Václav Havel Prague

Wed 6/17

12:30 pm-10:27 am

2 stops28h 57m

$1,031

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 5/27

6:00 am-5:55 pm

2 stops28h 55m

Václav Havel Prague

Wed 6/3

6:10 am-6:14 pm

2 stops19h 04m

$1,039

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Prague?

What is the cheapest month to fly to Prague?

In general, November is the cheapest month to fly from Des Moines to Prague. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you are unable to visit Prague during the month of November, then departing from Des Moines during the month February is also very affordable. Most momondo users find prices during this month for around $0.

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 3% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

16h 05m

Direct flights

None
The fastest flight from Des Moines to Prague takes 16h 05m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837