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Cheap flights from Des Moines to Prague from $506

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:48 pm - 4:05 pmDSM-PRG
14h 17m2 stops
United Airlines Logo
7:25 am - 8:34 pmPRG-DSM
20h 09m2 stops
$506United Airlines
Find Deal
Fri, Feb 6 - Tue, Feb 10
Delta Logo
11:26 am - 11:55 amDSM-PRG
17h 29m2 stops
Delta Logo
6:00 am - 10:29 pmPRG-DSM
23h 29m2 stops
$507Delta
Find Deal
Fri, Feb 6 - Tue, Feb 10
United Airlines Logo
5:06 pm - 10:25 pmDSM-PRG
46h 19m2 stops
United Airlines Logo
6:15 am - 9:50 pmPRG-DSM
22h 35m2 stops
$521United Airlines
Find Deal
Sun, Jan 4 - Sun, Jan 11
Lufthansa Logo
6:46 pm - 1:05 pmDSM-PRG
35h 19m2 stops
Lufthansa Logo
10:25 am - 9:50 pmPRG-DSM
18h 25m2 stops
$644Lufthansa
Find Deal
Mon, Jan 5 - Mon, Jan 12
Lufthansa Logo
6:46 pm - 9:50 amDSM-PRG
32h 04m2 stops
Lufthansa Logo
6:55 pm - 9:50 pmPRG-DSM
33h 55m2 stops
$647Lufthansa
Find Deal
Sat, Jan 3 - Sat, Jan 10
Lufthansa Logo
6:46 pm - 1:05 pmDSM-PRG
35h 19m2 stops
Lufthansa Logo
10:25 am - 9:50 pmPRG-DSM
18h 25m2 stops
$686Lufthansa
Find Deal
Mon, Jan 5 - Mon, Jan 12
Lufthansa Logo
6:46 pm - 6:15 pmDSM-PRG
16h 29m2 stops
Lufthansa Logo
10:25 am - 9:50 pmPRG-DSM
18h 25m2 stops
$690Lufthansa
Find Deal
Mon, Jan 5 - Mon, Jan 12
Lufthansa Logo
6:46 pm - 6:15 pmDSM-PRG
16h 29m2 stops
Lufthansa Logo
1:45 pm - 9:50 pmPRG-DSM
15h 05m2 stops
$694Lufthansa
Find Deal
Mon, Jan 5 - Mon, Jan 12
United Airlines Logo
8:00 am - 5:55 pmDSM-PRG
26h 55m2 stops
United Airlines Logo
1:45 pm - 2:33 pmPRG-DSM
31h 48m2 stops
$695United Airlines
Find Deal
Sun, Jan 4 - Sun, Jan 11
Lufthansa Logo
6:46 pm - 9:50 amDSM-PRG
32h 04m2 stops
Lufthansa Logo
6:55 pm - 9:50 pmPRG-DSM
33h 55m2 stops
$705Lufthansa
Find Deal
Sat, Jan 3 - Sat, Jan 10

United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Feb 6
DSM6:48 pmDes Moines
14h 17m
2 stops
PRG4:05 pmVáclav Havel Prague
Feb 10
PRG7:25 amVáclav Havel Prague
20h 09m
2 stops
DSM8:34 pmDes Moines
$506
Find similar
United Airlines
Jan 4
DSM5:06 pmDes Moines
46h 19m
2 stops
PRG10:25 pmVáclav Havel Prague
Jan 11
PRG6:15 amVáclav Havel Prague
22h 35m
2 stops
DSM9:50 pmDes Moines
$521
Find similar
United Airlines
Jan 4
DSM8:00 amDes Moines
26h 55m
2 stops
PRG5:55 pmVáclav Havel Prague
Jan 11
PRG1:45 pmVáclav Havel Prague
31h 48m
2 stops
DSM2:33 pmDes Moines
$695
Find similar

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Jan 5
DSM6:46 pmDes Moines
35h 19m
2 stops
PRG1:05 pmVáclav Havel Prague
Jan 12
PRG10:25 amVáclav Havel Prague
18h 25m
2 stops
DSM9:50 pmDes Moines
$644
Find similar
Lufthansa
Jan 3
DSM6:46 pmDes Moines
32h 04m
2 stops
PRG9:50 amVáclav Havel Prague
Jan 10
PRG6:55 pmVáclav Havel Prague
33h 55m
2 stops
DSM9:50 pmDes Moines
$647
Find similar
Lufthansa
Jan 5
DSM6:46 pmDes Moines
35h 19m
2 stops
PRG1:05 pmVáclav Havel Prague
Jan 12
PRG10:25 amVáclav Havel Prague
18h 25m
2 stops
DSM9:50 pmDes Moines
$686
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 22, 2025.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 2/6

6:48 pm-4:05 pm

2 stops14h 17m

Václav Havel Prague

Tue 2/10

7:25 am-8:34 pm

2 stops20h 09m

$506

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 2/6

11:26 am-11:55 am

2 stops17h 29m

Václav Havel Prague

Tue 2/10

6:00 am-10:29 pm

2 stops23h 29m

$507

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 1/4

5:06 pm-10:25 pm

2 stops46h 19m

Václav Havel Prague

Sun 1/11

6:15 am-9:50 pm

2 stops22h 35m

$521

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 1/5

6:46 pm-1:05 pm

2 stops35h 19m

Václav Havel Prague

Mon 1/12

10:25 am-9:50 pm

2 stops18h 25m

$644

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 1/3

6:46 pm-9:50 am

2 stops32h 04m

Václav Havel Prague

Sat 1/10

6:55 pm-9:50 pm

2 stops33h 55m

$647

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 1/5

6:46 pm-1:05 pm

2 stops35h 19m

Václav Havel Prague

Mon 1/12

10:25 am-9:50 pm

2 stops18h 25m

$686

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 1/5

6:46 pm-6:15 pm

2 stops16h 29m

Václav Havel Prague

Mon 1/12

10:25 am-9:50 pm

2 stops18h 25m

$690

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 1/5

6:46 pm-6:15 pm

2 stops16h 29m

Václav Havel Prague

Mon 1/12

1:45 pm-9:50 pm

2 stops15h 05m

$694

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 1/4

8:00 am-5:55 pm

2 stops26h 55m

Václav Havel Prague

Sun 1/11

1:45 pm-2:33 pm

2 stops31h 48m

$695

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 1/3

6:46 pm-9:50 am

2 stops32h 04m

Václav Havel Prague

Sat 1/10

6:55 pm-9:50 pm

2 stops33h 55m

$705

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Prague?

The cheapest day to depart from Des Moines to Prague is on a Tuesday. Travelers who choose to depart for Prague on a Tuesday will often find tickets for as low as $816. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Prague for around $1,811.

What is the cheapest time of day to depart on your flight to Prague?

According to our data, the cheapest time of day to fly to Prague is in the afternoon. momondo users have found flights departing from Des Moines to Prague in the afternoon for as low as $1,080. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $1,157. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Direct flights

None
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Václav Havel Prague Airport?

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Prague?

Best airlines flying from Des Moines to Prague

Compare and see reviews for airlines that fly from Des Moines to Prague with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,035 reviews
Search United Airlines flights

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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