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Cheap flights from Des Moines to Prague from $524

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 7/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:20 pm - 12:40 pm
DSM
-
PRG
14h 20m
2 stops
United Airlines Logo
12:30 pm - 5:28 pm
PRG
-
DSM
35h 58m
2 stops
$878United Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
7:49 pm - 8:10 pm
DSM
-
PRG
17h 21m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$882American Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
5:41 am - 8:15 am
DSM
-
PRG
19h 34m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$885American Airlines
Thu, Aug 13 - Sun, Aug 23
Lufthansa Logo
6:50 pm - 4:00 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$905Lufthansa
Mon, Jul 27 - Mon, Aug 3
Lufthansa Logo
6:50 pm - 4:00 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$913Lufthansa
Mon, Jul 27 - Mon, Aug 3
Multiple Airlines Logo
6:50 pm - 10:50 am
DSM
-
PRG
33h 00m
2 stops
Multiple Airlines Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$914Multiple Airlines
Mon, Jul 27 - Mon, Aug 3
Multiple Airlines Logo
6:50 pm - 10:50 am
DSM
-
PRG
33h 00m
2 stops
Multiple Airlines Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$915Multiple Airlines
Mon, Jul 27 - Mon, Aug 3
Lufthansa Logo
6:50 pm - 4:00 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
11:45 am - 10:56 pm
PRG
-
DSM
18h 11m
2 stops
$958Lufthansa
Fri, Jul 24 - Fri, Jul 31
Lufthansa Logo
6:50 pm - 10:55 am
DSM
-
PRG
33h 05m
2 stops
Lufthansa Logo
2:10 pm - 10:56 pm
PRG
-
DSM
15h 46m
2 stops
$975Lufthansa
Sun, Jul 26 - Sun, Aug 2
Multiple Airlines Logo
11:23 am - 10:50 am
DSM
-
PRG
16h 27m
2 stops
Multiple Airlines Logo
11:45 am - 10:56 pm
PRG
-
DSM
18h 11m
2 stops
$987Multiple Airlines
Fri, Jul 24 - Fri, Jul 31

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Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Jul 27
DSM6:50 pmDes Moines
14h 10m
2 stops
PRG4:00 pmVáclav Havel Prague
Aug 3
PRG6:35 pmVáclav Havel Prague
35h 21m
2 stops
DSM10:56 pmDes Moines
$905
Lufthansa
Jul 27
DSM6:50 pmDes Moines
14h 10m
2 stops
PRG4:00 pmVáclav Havel Prague
Aug 3
PRG6:35 pmVáclav Havel Prague
35h 21m
2 stops
DSM10:56 pmDes Moines
$913
Lufthansa
Jul 24
DSM6:50 pmDes Moines
14h 10m
2 stops
PRG4:00 pmVáclav Havel Prague
Jul 31
PRG11:45 amVáclav Havel Prague
18h 11m
2 stops
DSM10:56 pmDes Moines
$958

American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Aug 13
DSM7:49 pmDes Moines
17h 21m
2 stops
PRG8:10 pmVáclav Havel Prague
Aug 23
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$882
American Airlines
Aug 13
DSM5:41 amDes Moines
19h 34m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 23
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$885
American Airlines
Jul 27
DSM1:04 pmDes Moines
12h 11m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 3
PRG7:15 amVáclav Havel Prague
20h 03m
2 stops
DSM8:18 pmDes Moines
$1,124

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

3:20 pm-12:40 pm

2 stops14h 20m

Václav Havel Prague

Sun 8/23

12:30 pm-5:28 pm

2 stops35h 58m

$878

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

7:49 pm-8:10 pm

2 stops17h 21m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$882

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

5:41 am-8:15 am

1 stop19h 34m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$885

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-4:00 pm

2 stops14h 10m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$905

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-4:00 pm

2 stops14h 10m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$913

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-10:50 am

2 stops33h 00m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$914

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-10:50 am

2 stops33h 00m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$915
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 7/24

6:50 pm-4:00 pm

2 stops14h 10m

Václav Havel Prague

Fri 7/31

11:45 am-10:56 pm

2 stops18h 11m

$958

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 7/26

6:50 pm-10:55 am

2 stops33h 05m

Václav Havel Prague

Sun 8/2

2:10 pm-10:56 pm

2 stops15h 46m

$975

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 7/24

11:23 am-10:50 am

2 stops16h 27m

Václav Havel Prague

Fri 7/31

11:45 am-10:56 pm

2 stops18h 11m

$987

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 20m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 20m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837