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Cheap flights from Des Moines to Prague from $391

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:28 am - 5:05 pm
DSM
-
PRG
22h 37m
2 stops
Delta Logo
6:00 am - 8:50 pm
PRG
-
DSM
21h 50m
2 stops
$787Delta
Wed, Dec 2 - Sat, Dec 12
United Airlines Logo
6:15 am - 10:45 am
DSM
-
PRG
21h 30m
3 stops
United Airlines Logo
7:05 am - 7:25 pm
PRG
-
DSM
19h 20m
2 stops
$801United Airlines
Wed, Dec 2 - Sat, Dec 12
Delta Logo
5:59 pm - 3:00 pm
DSM
-
PRG
14h 01m
2 stops
Delta Logo
2:30 pm - 2:06 pm
PRG
-
DSM
30h 36m
2 stops
$846Delta
Mon, Sep 14 - Mon, Sep 21
Scandinavian Airlines Logo
11:31 am - 2:40 pm
DSM
-
PRG
20h 09m
2 stops
Scandinavian Airlines Logo
8:55 pm - 10:26 pm
PRG
-
DSM
32h 31m
2 stops
$854Scandinavian Airlines
Sat, Sep 12 - Sat, Sep 19
Air France Logo
5:35 pm - 3:00 pm
DSM
-
PRG
14h 25m
2 stops
Air France Logo
6:30 am - 4:48 pm
PRG
-
DSM
17h 18m
2 stops
$855Air France
Tue, Sep 15 - Tue, Sep 22
Lufthansa Logo
3:22 pm - 5:50 pm
DSM
-
PRG
19h 28m
2 stops
Lufthansa Logo
6:10 am - 5:28 pm
PRG
-
DSM
18h 18m
2 stops
$865Lufthansa
Tue, Sep 15 - Tue, Sep 22
Air Canada Logo
11:32 am - 10:50 am
DSM
-
PRG
40h 18m
2 stops
Air Canada Logo
12:30 pm - 12:20 pm
PRG
-
DSM
30h 50m
2 stops
$873Air Canada
Sat, Aug 15 - Wed, Aug 26
American Airlines Logo
7:58 pm - 5:05 pm
DSM
-
PRG
14h 07m
2 stops
American Airlines Logo
10:15 am - 12:31 pm
PRG
-
DSM
33h 16m
1 stop
$875American Airlines
Wed, Sep 16 - Wed, Sep 23
American Airlines Logo
1:09 pm - 8:15 am
DSM
-
PRG
12h 06m
1 stop
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$877American Airlines
Tue, Sep 15 - Tue, Sep 22
American Airlines Logo
6:00 am - 8:15 am
DSM
-
PRG
19h 15m
1 stop
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$878American Airlines
Wed, Sep 16 - Wed, Sep 23

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Scandinavian Airlines flights from Des Moines to Prague

Our best Scandinavian Airlines deals on Des Moines to Prague flight tickets
Scandinavian Airlines
Sep 12
DSM11:31 amDes Moines
20h 09m
2 stops
PRG2:40 pmVáclav Havel Prague
Sep 19
PRG8:55 pmVáclav Havel Prague
32h 31m
2 stops
DSM10:26 pmDes Moines
$854
Scandinavian Airlines
Aug 13
DSM6:35 pmDes Moines
42h 40m
2 stops
PRG8:15 pmVáclav Havel Prague
Aug 27
PRG8:55 pmVáclav Havel Prague
32h 42m
2 stops
DSM10:37 pmDes Moines
$953
Scandinavian Airlines
Sep 14
DSM2:34 pmDes Moines
20h 21m
3 stops
PRG5:55 pmVáclav Havel Prague
Sep 21
PRG10:20 amVáclav Havel Prague
19h 06m
2 stops
DSM10:26 pmDes Moines
$1,101

United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Dec 2
DSM6:15 amDes Moines
21h 30m
3 stops
PRG10:45 amVáclav Havel Prague
Dec 12
PRG7:05 amVáclav Havel Prague
19h 20m
2 stops
DSM7:25 pmDes Moines
$801
United Airlines
Sep 12
DSM3:02 pmDes Moines
36h 48m
3 stops
PRG10:50 amVáclav Havel Prague
Sep 19
PRG1:20 pmVáclav Havel Prague
39h 08m
2 stops
DSM9:28 pmDes Moines
$926

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 3, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 12/2

11:28 am-5:05 pm

2 stops22h 37m

Václav Havel Prague

Sat 12/12

6:00 am-8:50 pm

2 stops21h 50m

$787

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 12/2

6:15 am-10:45 am

3 stops21h 30m

Václav Havel Prague

Sat 12/12

7:05 am-7:25 pm

2 stops19h 20m

$801

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 9/14

5:59 pm-3:00 pm

2 stops14h 01m

Václav Havel Prague

Mon 9/21

2:30 pm-2:06 pm

2 stops30h 36m

$846

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 9/12

11:31 am-2:40 pm

2 stops20h 09m

Václav Havel Prague

Sat 9/19

8:55 pm-10:26 pm

2 stops32h 31m

$854

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/15

5:35 pm-3:00 pm

2 stops14h 25m

Václav Havel Prague

Tue 9/22

6:30 am-4:48 pm

2 stops17h 18m

$855

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/15

3:22 pm-5:50 pm

2 stops19h 28m

Václav Havel Prague

Tue 9/22

6:10 am-5:28 pm

2 stops18h 18m

$865

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 8/15

11:32 am-10:50 am

2 stops40h 18m

Václav Havel Prague

Wed 8/26

12:30 pm-12:20 pm

2 stops30h 50m

$873

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/16

7:58 pm-5:05 pm

2 stops14h 07m

Václav Havel Prague

Wed 9/23

10:15 am-12:31 pm

1 stop33h 16m

$875
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/15

1:09 pm-8:15 am

1 stop12h 06m

Václav Havel Prague

Tue 9/22

10:15 am-9:36 pm

1 stop18h 21m

$877

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/16

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Wed 9/23

10:15 am-9:36 pm

1 stop18h 21m

$878

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

12h 34m

Direct flights

None
The fastest flight from Des Moines to Prague takes 12h 34m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 12h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588