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Cheap flights from Des Moines to Prague from $365

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:00 am - 11:00 amDSM  Des Moines-PRG Václav Havel Prague
20h 00m3 stops Chicago O'Hare Intl Washington, D.C. Reagan-National Brussels Bruxelles-National
United Airlines Logo
12:30 pm - 10:31 amPRG  Václav Havel Prague-DSM Des Moines
29h 01m2 stops Toronto Pearson Intl Chicago O'Hare Intl
$827United Airlines
Tue, Sep 1 - Wed, Sep 16
Lufthansa Logo
6:45 pm - 10:40 pmDSM  Des Moines-PRG Václav Havel Prague
20h 55m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss
Lufthansa Logo
7:05 am - 10:25 pmPRG  Václav Havel Prague-DSM Des Moines
22h 20m2 stops Frankfurt am Main Chicago O'Hare Intl
$830Lufthansa
Sun, Nov 1 - Sun, Nov 8
United Airlines Logo
3:20 pm - 5:50 pmDSM  Des Moines-PRG Václav Havel Prague
19h 30m2 stops Chicago O'Hare Intl Frankfurt am Main
United Airlines Logo
12:30 pm - 10:31 amPRG  Václav Havel Prague-DSM Des Moines
29h 01m2 stops Toronto Pearson Intl Chicago O'Hare Intl
$838United Airlines
Tue, Sep 1 - Wed, Sep 16
KLM Logo
2:34 pm - 5:40 pmDSM  Des Moines-PRG Václav Havel Prague
20h 06m2 stops Atlanta Hartsfield-Jackson Amsterdam Schiphol
KLM Logo
8:20 pm - 2:06 pmPRG  Václav Havel Prague-DSM Des Moines
24h 46m2 stops Amsterdam Schiphol Minneapolis St Paul
$842KLM
Mon, Sep 14 - Mon, Sep 21
Delta Logo
5:59 pm - 3:00 pmDSM  Des Moines-PRG Václav Havel Prague
14h 01m2 stops Minneapolis St Paul Paris Charles de Gaulle
Delta Logo
2:30 pm - 2:06 pmPRG  Václav Havel Prague-DSM Des Moines
30h 36m2 stops Amsterdam Schiphol Minneapolis St Paul
$847Delta
Mon, Sep 14 - Mon, Sep 21
Delta Logo
7:15 am - 8:20 amDSM  Des Moines-PRG Václav Havel Prague
18h 05m2 stops New York LaGuardia Amsterdam Schiphol
Delta Logo
11:00 am - 10:26 pmPRG  Václav Havel Prague-DSM Des Moines
18h 26m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$848Delta
Tue, Sep 1 - Fri, Sep 11
Delta Logo
7:15 am - 8:20 amDSM  Des Moines-PRG Václav Havel Prague
18h 05m2 stops New York LaGuardia Amsterdam Schiphol
Delta Logo
11:00 am - 11:32 amPRG  Václav Havel Prague-DSM Des Moines
31h 32m1 stop New York John F Kennedy Intl
$849Delta
Tue, Sep 1 - Fri, Sep 11
United Airlines Logo
8:00 am - 11:00 amDSM  Des Moines-PRG Václav Havel Prague
20h 00m3 stops Chicago O'Hare Intl Washington, D.C. Reagan-National Brussels Bruxelles-National
United Airlines Logo
6:00 am - 5:57 pmPRG  Václav Havel Prague-DSM Des Moines
18h 57m2 stops Frankfurt am Main Chicago O'Hare Intl
$850United Airlines
Tue, Sep 1 - Thu, Sep 10
Delta Logo
4:11 pm - 5:40 pmDSM  Des Moines-PRG Václav Havel Prague
18h 29m2 stops Atlanta Hartsfield-Jackson Amsterdam Schiphol
Delta Logo
2:30 pm - 2:06 pmPRG  Václav Havel Prague-DSM Des Moines
30h 36m2 stops Amsterdam Schiphol Minneapolis St Paul
$851Delta
Tue, Sep 1 - Mon, Sep 14
Scandinavian Airlines Logo
2:34 pm - 9:40 amDSM  Des Moines-PRG Václav Havel Prague
36h 06m2 stops Atlanta Hartsfield-Jackson Kastrup Copenhagen
Scandinavian Airlines Logo
3:20 pm - 10:33 pmPRG  Václav Havel Prague-DSM Des Moines
38h 13m2 stops Kastrup Copenhagen Atlanta Hartsfield-Jackson
$860Scandinavian Airlines
Fri, Oct 2 - Wed, Oct 7

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American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Sep 14
DSM1:09 pmDes Moines
12h 06m
1 stop
PRG8:15 amVáclav Havel Prague
Sep 21
PRG10:15 amVáclav Havel Prague
18h 21m
1 stop
DSM9:36 pmDes Moines
$886
American Airlines
Sep 14
DSM1:09 pmDes Moines
12h 06m
1 stop
PRG8:15 amVáclav Havel Prague
Sep 21
PRG7:15 amVáclav Havel Prague
17h 11m
2 stops
DSM5:26 pmDes Moines
$905
American Airlines
Sep 17
DSM1:09 pmDes Moines
12h 06m
1 stop
PRG8:15 amVáclav Havel Prague
Sep 24
PRG10:15 amVáclav Havel Prague
33h 16m
1 stop
DSM12:31 pmDes Moines
$935

Delta flights from Des Moines to Prague

Our best Delta deals on Des Moines to Prague flight tickets
Delta
Sep 14
DSM5:59 pmDes Moines
14h 01m
2 stops
PRG3:00 pmVáclav Havel Prague
Sep 21
PRG2:30 pmVáclav Havel Prague
30h 36m
2 stops
DSM2:06 pmDes Moines
$847
Delta
Sep 1
DSM7:15 amDes Moines
18h 05m
2 stops
PRG8:20 amVáclav Havel Prague
Sep 11
PRG11:00 amVáclav Havel Prague
18h 26m
2 stops
DSM10:26 pmDes Moines
$848
Delta
Sep 1
DSM7:15 amDes Moines
18h 05m
2 stops
PRG8:20 amVáclav Havel Prague
Sep 11
PRG11:00 amVáclav Havel Prague
31h 32m
1 stop
DSM11:32 amDes Moines
$849

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

8:00 am-11:00 am

3 stops20h 00m

Václav Havel Prague

Wed 9/16

12:30 pm-10:31 am

2 stops29h 01m

$827

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Sun 11/1

6:45 pm-10:40 pm

2 stops20h 55m

Václav Havel Prague

Sun 11/8

7:05 am-10:25 pm

2 stops22h 20m

$830

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

3:20 pm-5:50 pm

2 stops19h 30m

Václav Havel Prague

Wed 9/16

12:30 pm-10:31 am

2 stops29h 01m

$838

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Mon 9/14

2:34 pm-5:40 pm

2 stops20h 06m

Václav Havel Prague

Mon 9/21

8:20 pm-2:06 pm

2 stops24h 46m

$842

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Mon 9/14

5:59 pm-3:00 pm

2 stops14h 01m

Václav Havel Prague

Mon 9/21

2:30 pm-2:06 pm

2 stops30h 36m

$847
Quickest round-trip

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

7:15 am-8:20 am

2 stops18h 05m

Václav Havel Prague

Fri 9/11

11:00 am-10:26 pm

2 stops18h 26m

$848

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

7:15 am-8:20 am

2 stops18h 05m

Václav Havel Prague

Fri 9/11

11:00 am-11:32 am

1 stop31h 32m

$849

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

8:00 am-11:00 am

3 stops20h 00m

Václav Havel Prague

Thu 9/10

6:00 am-5:57 pm

2 stops18h 57m

$850

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/1

4:11 pm-5:40 pm

2 stops18h 29m

Václav Havel Prague

Mon 9/14

2:30 pm-2:06 pm

2 stops30h 36m

$851

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Fri 10/2

2:34 pm-9:40 am

2 stops36h 06m

Václav Havel Prague

Wed 10/7

3:20 pm-10:33 pm

2 stops38h 13m

$860

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 20m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 20m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
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Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588