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Cheap flights from Des Moines to Prague from $441

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:21 pm - 8:55 am
DSM
-
PRG
12h 34m
2 stops
Multiple Airlines Logo
12:30 pm - 8:26 pm
PRG
-
DSM
38h 56m
2 stops
$758Multiple Airlines
Wed, Aug 19 - Wed, Aug 26
Multiple Airlines Logo
5:56 pm - 1:45 pm
DSM
-
PRG
12h 49m
2 stops
Multiple Airlines Logo
6:30 am - 5:11 pm
PRG
-
DSM
17h 41m
2 stops
$761Multiple Airlines
Wed, Aug 19 - Wed, Aug 26
American Airlines Logo
1:08 pm - 11:30 am
DSM
-
PRG
15h 22m
2 stops
American Airlines Logo
10:15 am - 12:34 pm
PRG
-
DSM
33h 19m
1 stop
$774American Airlines
Tue, Aug 18 - Tue, Aug 25
United Airlines Logo
1:21 pm - 8:55 am
DSM
-
PRG
12h 34m
2 stops
United Airlines Logo
12:30 pm - 12:20 pm
PRG
-
DSM
30h 50m
2 stops
$777United Airlines
Wed, Aug 19 - Wed, Aug 26
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$778American Airlines
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$780American Airlines
Wed, Aug 19 - Wed, Aug 26
American Airlines Logo
1:08 pm - 11:30 am
DSM
-
PRG
15h 22m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$781American Airlines
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
7:49 pm - 8:50 pm
DSM
-
PRG
18h 01m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$784American Airlines
Wed, Aug 19 - Wed, Aug 26
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$785American Airlines
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
5:10 pm - 4:25 pm
DSM
-
PRG
16h 15m
2 stops
American Airlines Logo
10:15 am - 12:20 am
PRG
-
DSM
21h 05m
2 stops
$786American Airlines
Tue, Aug 18 - Tue, Aug 25

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American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Aug 18
DSM1:08 pmDes Moines
15h 22m
2 stops
PRG11:30 amVáclav Havel Prague
Aug 25
PRG10:15 amVáclav Havel Prague
33h 19m
1 stop
DSM12:34 pmDes Moines
$774
American Airlines
Aug 18
DSM1:07 pmDes Moines
12h 08m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 25
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$778
American Airlines
Aug 19
DSM5:40 amDes Moines
19h 35m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 26
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$780

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Aug 18
DSM3:20 pmDes Moines
34h 35m
2 stops
PRG8:55 amVáclav Havel Prague
Aug 25
PRG11:40 amVáclav Havel Prague
36h 48m
2 stops
DSM5:28 pmDes Moines
$788
Lufthansa
Aug 21
DSM1:21 pmDes Moines
12h 34m
2 stops
PRG8:55 amVáclav Havel Prague
Aug 28
PRG2:30 pmVáclav Havel Prague
33h 58m
2 stops
DSM5:28 pmDes Moines
$850
Lufthansa
Aug 23
DSM1:21 pmDes Moines
12h 34m
2 stops
PRG8:55 amVáclav Havel Prague
Aug 30
PRG1:20 pmVáclav Havel Prague
15h 03m
2 stops
DSM9:23 pmDes Moines
$865

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 9, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

1:21 pm-8:55 am

2 stops12h 34m

Václav Havel Prague

Wed 8/26

12:30 pm-8:26 pm

2 stops38h 56m

$758
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

5:56 pm-1:45 pm

2 stops12h 49m

Václav Havel Prague

Wed 8/26

6:30 am-5:11 pm

2 stops17h 41m

$761

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/18

1:08 pm-11:30 am

2 stops15h 22m

Václav Havel Prague

Tue 8/25

10:15 am-12:34 pm

1 stop33h 19m

$774

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

1:21 pm-8:55 am

2 stops12h 34m

Václav Havel Prague

Wed 8/26

12:30 pm-12:20 pm

2 stops30h 50m

$777

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/18

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 8/25

10:15 am-10:06 pm

1 stop18h 51m

$778

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Wed 8/26

10:15 am-10:06 pm

1 stop18h 51m

$780

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/18

1:08 pm-11:30 am

2 stops15h 22m

Václav Havel Prague

Tue 8/25

10:15 am-10:06 pm

1 stop18h 51m

$781

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

7:49 pm-8:50 pm

2 stops18h 01m

Václav Havel Prague

Wed 8/26

10:15 am-10:06 pm

1 stop18h 51m

$784

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/18

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 8/25

10:15 am-10:06 pm

1 stop18h 51m

$785

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/18

5:10 pm-4:25 pm

2 stops16h 15m

Václav Havel Prague

Tue 8/25

10:15 am-12:20 am

2 stops21h 05m

$786

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

12h 34m

Direct flights

None
The fastest flight from Des Moines to Prague takes 12h 34m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 12h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,779