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Cheap flights from Des Moines to Prague from $317

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
5:21 pm - 10:50 am
DSM
-
PRG
58h 29m
2 stops
Air Canada Logo
12:30 pm - 2:16 pm
PRG
-
DSM
32h 46m
2 stops
$833Air Canada
Fri, Aug 14 - Sun, Aug 23
Lufthansa Logo
6:55 pm - 4:05 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
6:00 am - 5:33 pm
PRG
-
DSM
18h 33m
2 stops
$834Lufthansa
Thu, Oct 8 - Fri, Oct 16
Delta Logo
5:56 pm - 7:35 pm
DSM
-
PRG
18h 39m
2 stops
Delta Logo
6:00 am - 5:11 pm
PRG
-
DSM
18h 11m
2 stops
$871Delta
Wed, Aug 5 - Wed, Aug 12
American Airlines Logo
7:49 pm - 5:05 pm
DSM
-
PRG
14h 16m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$872American Airlines
Thu, Aug 6 - Thu, Aug 13
Air Canada Logo
6:50 pm - 10:50 am
DSM
-
PRG
33h 00m
2 stops
Air Canada Logo
12:30 pm - 10:26 am
PRG
-
DSM
28h 56m
2 stops
$873Air Canada
Mon, Aug 3 - Mon, Aug 10
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$875American Airlines
Thu, Aug 6 - Thu, Aug 13
United Airlines Logo
1:35 pm - 12:40 pm
DSM
-
PRG
16h 05m
2 stops
United Airlines Logo
12:30 pm - 5:28 pm
PRG
-
DSM
35h 58m
2 stops
$877United Airlines
Fri, Aug 14 - Sun, Aug 23
American Airlines Logo
5:10 pm - 5:05 pm
DSM
-
PRG
16h 55m
2 stops
American Airlines Logo
10:05 am - 10:06 pm
PRG
-
DSM
19h 01m
2 stops
$890American Airlines
Thu, Aug 6 - Thu, Aug 13
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
7:05 am - 6:41 pm
PRG
-
DSM
18h 36m
2 stops
$893American Airlines
Thu, Aug 6 - Thu, Aug 13
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
6:30 am - 5:52 pm
PRG
-
DSM
18h 22m
2 stops
$894American Airlines
Wed, Aug 5 - Wed, Aug 12

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American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Aug 6
DSM7:49 pmDes Moines
14h 16m
2 stops
PRG5:05 pmVáclav Havel Prague
Aug 13
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$872
American Airlines
Aug 6
DSM1:07 pmDes Moines
12h 08m
1 stop
PRG8:15 amVáclav Havel Prague
Aug 13
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$875
American Airlines
Aug 6
DSM5:10 pmDes Moines
16h 55m
2 stops
PRG5:05 pmVáclav Havel Prague
Aug 13
PRG10:05 amVáclav Havel Prague
19h 01m
2 stops
DSM10:06 pmDes Moines
$890

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Aug 14
DSM5:21 pmDes Moines
58h 29m
2 stops
PRG10:50 amVáclav Havel Prague
Aug 23
PRG12:30 pmVáclav Havel Prague
32h 46m
2 stops
DSM2:16 pmDes Moines
$833
Air Canada
Aug 3
DSM6:50 pmDes Moines
33h 00m
2 stops
PRG10:50 amVáclav Havel Prague
Aug 10
PRG12:30 pmVáclav Havel Prague
28h 56m
2 stops
DSM10:26 amDes Moines
$873
Air Canada
Aug 2
DSM6:00 amDes Moines
21h 50m
2 stops
PRG10:50 amVáclav Havel Prague
Aug 9
PRG12:30 pmVáclav Havel Prague
52h 56m
2 stops
DSM10:26 amDes Moines
$963

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

5:21 pm-10:50 am

2 stops58h 29m

Václav Havel Prague

Sun 8/23

12:30 pm-2:16 pm

2 stops32h 46m

$833

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 10/8

6:55 pm-4:05 pm

2 stops14h 10m

Václav Havel Prague

Fri 10/16

6:00 am-5:33 pm

2 stops18h 33m

$834

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/5

5:56 pm-7:35 pm

2 stops18h 39m

Václav Havel Prague

Wed 8/12

6:00 am-5:11 pm

2 stops18h 11m

$871

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/6

7:49 pm-5:05 pm

2 stops14h 16m

Václav Havel Prague

Thu 8/13

10:15 am-10:06 pm

1 stop18h 51m

$872

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/3

6:50 pm-10:50 am

2 stops33h 00m

Václav Havel Prague

Mon 8/10

12:30 pm-10:26 am

2 stops28h 56m

$873

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/6

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Thu 8/13

10:15 am-10:06 pm

1 stop18h 51m

$875

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

1:35 pm-12:40 pm

2 stops16h 05m

Václav Havel Prague

Sun 8/23

12:30 pm-5:28 pm

2 stops35h 58m

$877

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/6

5:10 pm-5:05 pm

2 stops16h 55m

Václav Havel Prague

Thu 8/13

10:05 am-10:06 pm

2 stops19h 01m

$890

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/6

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Thu 8/13

7:05 am-6:41 pm

2 stops18h 36m

$893
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/5

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Wed 8/12

6:30 am-5:52 pm

2 stops18h 22m

$894

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 10m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 10m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 10m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837