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Cheap flights from Des Moines to Prague from $387

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:45 pm - 4:05 pm
DSM
-
PRG
38h 20m
2 stops
Lufthansa Logo
2:50 pm - 11:01 pm
PRG
-
DSM
15h 11m
2 stops
$745Lufthansa
Sat, Nov 14 - Wed, Nov 18
Air Canada Logo
5:45 am - 10:50 am
DSM
-
PRG
46h 05m
2 stops
Air Canada Logo
12:30 pm - 2:15 pm
PRG
-
DSM
32h 45m
2 stops
$775Air Canada
Mon, Aug 31 - Wed, Sep 23
Air Canada Logo
5:21 pm - 10:50 am
DSM
-
PRG
58h 29m
2 stops
Air Canada Logo
12:30 pm - 2:15 pm
PRG
-
DSM
32h 45m
2 stops
$780Air Canada
Fri, Sep 4 - Wed, Sep 23
American Airlines Logo
7:49 pm - 8:50 pm
DSM
-
PRG
18h 01m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$782American Airlines
Wed, Aug 19 - Tue, Aug 25
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$786American Airlines
Wed, Aug 19 - Tue, Aug 25
American Airlines Logo
7:49 pm - 8:50 pm
DSM
-
PRG
18h 01m
2 stops
American Airlines Logo
10:15 am - 12:20 am
PRG
-
DSM
21h 05m
2 stops
$787American Airlines
Wed, Aug 19 - Tue, Aug 25
Lufthansa Logo
1:10 pm - 4:05 pm
DSM
-
PRG
19h 55m
2 stops
Lufthansa Logo
6:10 am - 2:20 pm
PRG
-
DSM
15h 10m
2 stops
$796Lufthansa
Wed, Sep 2 - Tue, Sep 22
United Airlines Logo
6:15 am - 10:45 am
DSM
-
PRG
21h 30m
3 stops
United Airlines Logo
2:50 pm - 12:40 am
PRG
-
DSM
16h 50m
2 stops
$802United Airlines
Sat, Nov 14 - Wed, Nov 18
Multiple Airlines Logo
6:33 am - 6:45 pm
DSM
-
PRG
29h 12m
2 stops
Multiple Airlines Logo
7:30 pm - 11:13 pm
PRG
-
DSM
34h 43m
2 stops
$806Multiple Airlines
Tue, Sep 1 - Mon, Sep 21
Lufthansa Logo
11:32 am - 10:50 am
DSM
-
PRG
16h 18m
2 stops
Lufthansa Logo
6:10 am - 2:20 pm
PRG
-
DSM
15h 10m
2 stops
$807Lufthansa
Tue, Sep 1 - Tue, Sep 22

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Nov 14
DSM6:45 pmDes Moines
38h 20m
2 stops
PRG4:05 pmVáclav Havel Prague
Nov 18
PRG2:50 pmVáclav Havel Prague
15h 11m
2 stops
DSM11:01 pmDes Moines
$745
Lufthansa
Sep 2
DSM1:10 pmDes Moines
19h 55m
2 stops
PRG4:05 pmVáclav Havel Prague
Sep 22
PRG6:10 amVáclav Havel Prague
15h 10m
2 stops
DSM2:20 pmDes Moines
$796
Lufthansa
Sep 1
DSM11:32 amDes Moines
16h 18m
2 stops
PRG10:50 amVáclav Havel Prague
Sep 22
PRG6:10 amVáclav Havel Prague
15h 10m
2 stops
DSM2:20 pmDes Moines
$807

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Aug 31
DSM5:45 amDes Moines
46h 05m
2 stops
PRG10:50 amVáclav Havel Prague
Sep 23
PRG12:30 pmVáclav Havel Prague
32h 45m
2 stops
DSM2:15 pmDes Moines
$775
Air Canada
Sep 4
DSM5:21 pmDes Moines
58h 29m
2 stops
PRG10:50 amVáclav Havel Prague
Sep 23
PRG12:30 pmVáclav Havel Prague
32h 45m
2 stops
DSM2:15 pmDes Moines
$780
Air Canada
Aug 30
DSM5:21 pmDes Moines
58h 29m
2 stops
PRG10:50 amVáclav Havel Prague
Sep 23
PRG12:30 pmVáclav Havel Prague
29h 01m
2 stops
DSM10:31 amDes Moines
$833

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 3, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 11/14

6:45 pm-4:05 pm

2 stops38h 20m

Václav Havel Prague

Wed 11/18

2:50 pm-11:01 pm

2 stops15h 11m

$745

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/31

5:45 am-10:50 am

2 stops46h 05m

Václav Havel Prague

Wed 9/23

12:30 pm-2:15 pm

2 stops32h 45m

$775

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 9/4

5:21 pm-10:50 am

2 stops58h 29m

Václav Havel Prague

Wed 9/23

12:30 pm-2:15 pm

2 stops32h 45m

$780

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

7:49 pm-8:50 pm

2 stops18h 01m

Václav Havel Prague

Tue 8/25

10:15 am-10:06 pm

1 stop18h 51m

$782
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 8/25

10:15 am-10:06 pm

1 stop18h 51m

$786

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/19

7:49 pm-8:50 pm

2 stops18h 01m

Václav Havel Prague

Tue 8/25

10:15 am-12:20 am

2 stops21h 05m

$787

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/2

1:10 pm-4:05 pm

2 stops19h 55m

Václav Havel Prague

Tue 9/22

6:10 am-2:20 pm

2 stops15h 10m

$796

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 11/14

6:15 am-10:45 am

3 stops21h 30m

Václav Havel Prague

Wed 11/18

2:50 pm-12:40 am

2 stops16h 50m

$802

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/1

6:33 am-6:45 pm

2 stops29h 12m

Václav Havel Prague

Mon 9/21

7:30 pm-11:13 pm

2 stops34h 43m

$806

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/1

11:32 am-10:50 am

2 stops16h 18m

Václav Havel Prague

Tue 9/22

6:10 am-2:20 pm

2 stops15h 10m

$807

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 6% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 20m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 20m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837