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Cheap flights from Des Moines to Prague from $517

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 7/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:50 pm - 8:55 am
DSM
-
PRG
31h 05m
2 stops
Lufthansa Logo
4:40 pm - 9:22 pm
PRG
-
DSM
35h 42m
2 stops
$867Lufthansa
Tue, Jul 28 - Tue, Aug 4
United Airlines Logo
3:20 pm - 12:40 pm
DSM
-
PRG
14h 20m
2 stops
United Airlines Logo
12:30 pm - 5:28 pm
PRG
-
DSM
35h 58m
2 stops
$878United Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
7:49 pm - 8:10 pm
DSM
-
PRG
17h 21m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$882American Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
5:41 am - 8:15 am
DSM
-
PRG
19h 34m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$886American Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
6:33 pm - 5:05 pm
DSM
-
PRG
15h 32m
2 stops
American Airlines Logo
6:30 am - 6:41 pm
PRG
-
DSM
19h 11m
2 stops
$893American Airlines
Wed, Jul 29 - Wed, Aug 5
Lufthansa Logo
6:50 pm - 4:00 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
4:40 pm - 9:22 pm
PRG
-
DSM
35h 42m
2 stops
$902Lufthansa
Tue, Jul 28 - Tue, Aug 4
Lufthansa Logo
6:50 pm - 4:00 pm
DSM
-
PRG
14h 10m
2 stops
Lufthansa Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$905Lufthansa
Mon, Jul 27 - Mon, Aug 3
American Airlines Logo
1:04 pm - 8:15 am
DSM
-
PRG
12h 11m
1 stop
American Airlines Logo
6:30 am - 6:41 pm
PRG
-
DSM
19h 11m
2 stops
$906American Airlines
Wed, Jul 29 - Wed, Aug 5
United Airlines Logo
6:00 am - 11:00 am
DSM
-
PRG
22h 00m
3 stops
United Airlines Logo
1:20 pm - 9:22 pm
PRG
-
DSM
39h 02m
2 stops
$911United Airlines
Tue, Jul 28 - Tue, Aug 4
Multiple Airlines Logo
6:50 pm - 10:50 am
DSM
-
PRG
33h 00m
2 stops
Multiple Airlines Logo
6:35 pm - 10:56 pm
PRG
-
DSM
35h 21m
2 stops
$915Multiple Airlines
Mon, Jul 27 - Mon, Aug 3

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Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Jul 28
DSM6:50 pmDes Moines
31h 05m
2 stops
PRG8:55 amVáclav Havel Prague
Aug 4
PRG4:40 pmVáclav Havel Prague
35h 42m
2 stops
DSM9:22 pmDes Moines
$867
Lufthansa
Jul 28
DSM6:50 pmDes Moines
14h 10m
2 stops
PRG4:00 pmVáclav Havel Prague
Aug 4
PRG4:40 pmVáclav Havel Prague
35h 42m
2 stops
DSM9:22 pmDes Moines
$902
Lufthansa
Jul 30
DSM11:23 amDes Moines
18h 17m
2 stops
PRG12:40 pmVáclav Havel Prague
Aug 6
PRG6:15 amVáclav Havel Prague
23h 41m
2 stops
DSM10:56 pmDes Moines
$944

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Jul 30
DSM7:35 amDes Moines
17h 55m
3 stops
PRG8:30 amVáclav Havel Prague
Aug 6
PRG11:40 amVáclav Havel Prague
18h 16m
3 stops
DSM10:56 pmDes Moines
$1,346
Air Canada
Jul 29
DSM11:23 amDes Moines
16h 27m
3 stops
PRG10:50 amVáclav Havel Prague
Aug 5
PRG11:30 amVáclav Havel Prague
18h 26m
3 stops
DSM10:56 pmDes Moines
$1,405
Air Canada
Jul 31
DSM11:23 amDes Moines
16h 52m
3 stops
PRG11:15 amVáclav Havel Prague
Aug 7
PRG9:35 amVáclav Havel Prague
18h 47m
3 stops
DSM9:22 pmDes Moines
$1,631

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 7/28

6:50 pm-8:55 am

2 stops31h 05m

Václav Havel Prague

Tue 8/4

4:40 pm-9:22 pm

2 stops35h 42m

$867

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

3:20 pm-12:40 pm

2 stops14h 20m

Václav Havel Prague

Sun 8/23

12:30 pm-5:28 pm

2 stops35h 58m

$878

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

7:49 pm-8:10 pm

2 stops17h 21m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$882

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

5:41 am-8:15 am

1 stop19h 34m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$886

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/29

6:33 pm-5:05 pm

2 stops15h 32m

Václav Havel Prague

Wed 8/5

6:30 am-6:41 pm

2 stops19h 11m

$893

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 7/28

6:50 pm-4:00 pm

2 stops14h 10m

Václav Havel Prague

Tue 8/4

4:40 pm-9:22 pm

2 stops35h 42m

$902

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-4:00 pm

2 stops14h 10m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$905
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 7/29

1:04 pm-8:15 am

1 stop12h 11m

Václav Havel Prague

Wed 8/5

6:30 am-6:41 pm

2 stops19h 11m

$906

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 7/28

6:00 am-11:00 am

3 stops22h 00m

Václav Havel Prague

Tue 8/4

1:20 pm-9:22 pm

2 stops39h 02m

$911

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 7/27

6:50 pm-10:50 am

2 stops33h 00m

Václav Havel Prague

Mon 8/3

6:35 pm-10:56 pm

2 stops35h 21m

$915

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

16h 45m

Direct flights

None
The fastest flight from Des Moines to Prague takes 16h 45m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $2,837