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Cheap flights from Des Moines to Prague from $434

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:32 am - 8:55 am
DSM
-
PRG
14h 23m
2 stops
United Airlines Logo
12:30 pm - 12:20 pm
PRG
-
DSM
30h 50m
2 stops
$776United Airlines
Wed, Aug 12 - Wed, Aug 19
American Airlines Logo
1:55 pm - 1:15 pm
DSM
-
PRG
16h 20m
2 stops
American Airlines Logo
10:30 am - 10:06 pm
PRG
-
DSM
18h 36m
2 stops
$790American Airlines
Wed, Aug 12 - Wed, Aug 19
KLM Logo
5:30 pm - 5:40 pm
DSM
-
PRG
17h 10m
2 stops
KLM Logo
6:35 pm - 2:04 pm
PRG
-
DSM
26h 29m
2 stops
$792KLM
Tue, Aug 11 - Tue, Aug 18
Delta Logo
5:30 pm - 9:40 pm
DSM
-
PRG
21h 10m
2 stops
Delta Logo
2:30 pm - 2:04 pm
PRG
-
DSM
30h 34m
2 stops
$796Delta
Wed, Aug 12 - Wed, Aug 19
American Airlines Logo
7:49 pm - 5:05 pm
DSM
-
PRG
14h 16m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$817American Airlines
Wed, Aug 12 - Wed, Aug 19
American Airlines Logo
5:10 pm - 4:25 pm
DSM
-
PRG
16h 15m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$830American Airlines
Tue, Aug 11 - Tue, Aug 18
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$834American Airlines
Tue, Aug 11 - Tue, Aug 18
Multiple Airlines Logo
10:59 am - 9:00 am
DSM
-
PRG
15h 01m
2 stops
Multiple Airlines Logo
6:00 am - 5:11 pm
PRG
-
DSM
18h 11m
2 stops
$835Multiple Airlines
Thu, Aug 13 - Thu, Aug 20
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:05 am - 7:19 pm
PRG
-
DSM
16h 14m
2 stops
$845American Airlines
Thu, Aug 13 - Thu, Aug 20
Air France Logo
5:30 pm - 9:40 pm
DSM
-
PRG
21h 10m
2 stops
Air France Logo
8:25 pm - 8:59 pm
PRG
-
DSM
31h 34m
2 stops
$857Air France
Mon, Aug 10 - Mon, Aug 17

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Delta flights from Des Moines to Prague

Our best Delta deals on Des Moines to Prague flight tickets
Delta
Aug 12
DSM5:30 pmDes Moines
21h 10m
2 stops
PRG9:40 pmVáclav Havel Prague
Aug 19
PRG2:30 pmVáclav Havel Prague
30h 34m
2 stops
DSM2:04 pmDes Moines
$796
Delta
Aug 5
DSM5:56 pmDes Moines
18h 39m
2 stops
PRG7:35 pmVáclav Havel Prague
Aug 12
PRG8:50 amVáclav Havel Prague
19h 09m
2 stops
DSM8:59 pmDes Moines
$871
Delta
Jul 24
DSM5:52 pmDes Moines
20h 53m
2 stops
PRG9:45 pmVáclav Havel Prague
Jul 31
PRG11:40 amVáclav Havel Prague
29h 05m
2 stops
DSM9:45 amDes Moines
$1,106

American Airlines flights from Des Moines to Prague

Our best American Airlines deals on Des Moines to Prague flight tickets
American Airlines
Aug 12
DSM1:55 pmDes Moines
16h 20m
2 stops
PRG1:15 pmVáclav Havel Prague
Aug 19
PRG10:30 amVáclav Havel Prague
18h 36m
2 stops
DSM10:06 pmDes Moines
$790
American Airlines
Aug 12
DSM7:49 pmDes Moines
14h 16m
2 stops
PRG5:05 pmVáclav Havel Prague
Aug 19
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$817
American Airlines
Aug 11
DSM5:10 pmDes Moines
16h 15m
2 stops
PRG4:25 pmVáclav Havel Prague
Aug 18
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
$830

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 29, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/12

11:32 am-8:55 am

2 stops14h 23m

Václav Havel Prague

Wed 8/19

12:30 pm-12:20 pm

2 stops30h 50m

$776

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/12

1:55 pm-1:15 pm

2 stops16h 20m

Václav Havel Prague

Wed 8/19

10:30 am-10:06 pm

2 stops18h 36m

$790

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/11

5:30 pm-5:40 pm

2 stops17h 10m

Václav Havel Prague

Tue 8/18

6:35 pm-2:04 pm

2 stops26h 29m

$792

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/12

5:30 pm-9:40 pm

2 stops21h 10m

Václav Havel Prague

Wed 8/19

2:30 pm-2:04 pm

2 stops30h 34m

$796
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/12

7:49 pm-5:05 pm

2 stops14h 16m

Václav Havel Prague

Wed 8/19

10:15 am-10:06 pm

1 stop18h 51m

$817

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/11

5:10 pm-4:25 pm

2 stops16h 15m

Václav Havel Prague

Tue 8/18

10:15 am-10:06 pm

1 stop18h 51m

$830

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/11

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Tue 8/18

10:15 am-10:06 pm

1 stop18h 51m

$834

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

10:59 am-9:00 am

2 stops15h 01m

Václav Havel Prague

Thu 8/20

6:00 am-5:11 pm

2 stops18h 11m

$835

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Thu 8/20

10:05 am-7:19 pm

2 stops16h 14m

$845

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/10

5:30 pm-9:40 pm

2 stops21h 10m

Václav Havel Prague

Mon 8/17

8:25 pm-8:59 pm

2 stops31h 34m

$857

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

12h 34m

Direct flights

None
The fastest flight from Des Moines to Prague takes 12h 34m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 12h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588