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Cheap flights from Des Moines to Prague from $345

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
3:22 pm - 5:50 pm
DSM
-
PRG
19h 28m
2 stops
Lufthansa Logo
6:10 am - 9:28 pm
PRG
-
DSM
22h 18m
2 stops
$825Lufthansa
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
6:22 pm - 5:05 pm
DSM
-
PRG
15h 43m
2 stops
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$828American Airlines
Wed, Sep 9 - Wed, Sep 16
United Airlines Logo
8:00 am - 11:00 am
DSM
-
PRG
20h 00m
3 stops
United Airlines Logo
12:30 pm - 10:31 am
PRG
-
DSM
29h 01m
2 stops
$831United Airlines
Tue, Sep 1 - Wed, Sep 16
American Airlines Logo
5:56 pm - 5:05 pm
DSM
-
PRG
16h 09m
2 stops
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$834American Airlines
Wed, Sep 9 - Wed, Sep 16
American Airlines Logo
1:08 pm - 11:30 am
DSM
-
PRG
15h 22m
2 stops
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$836American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
5:41 am - 8:15 am
DSM
-
PRG
19h 34m
1 stop
American Airlines Logo
10:15 am - 9:36 pm
PRG
-
DSM
18h 21m
1 stop
$839American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
1:08 pm - 11:30 am
DSM
-
PRG
15h 22m
2 stops
American Airlines Logo
10:15 am - 12:04 am
PRG
-
DSM
20h 49m
2 stops
$840American Airlines
Tue, Sep 8 - Tue, Sep 15
Multiple Airlines Logo
4:11 pm - 3:00 pm
DSM
-
PRG
15h 49m
2 stops
Multiple Airlines Logo
6:00 am - 5:19 pm
PRG
-
DSM
18h 19m
2 stops
$843Multiple Airlines
Wed, Sep 9 - Wed, Sep 16
Delta Logo
5:30 pm - 3:00 pm
DSM
-
PRG
14h 30m
2 stops
Delta Logo
2:30 pm - 2:06 pm
PRG
-
DSM
30h 36m
2 stops
$851Delta
Mon, Sep 7 - Mon, Sep 14
Delta Logo
7:15 am - 8:20 am
DSM
-
PRG
18h 05m
2 stops
Delta Logo
11:00 am - 8:46 pm
PRG
-
DSM
16h 46m
2 stops
$852Delta
Tue, Sep 1 - Tue, Sep 15

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United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Sep 1
DSM8:00 amDes Moines
20h 00m
3 stops
PRG11:00 amVáclav Havel Prague
Sep 16
PRG12:30 pmVáclav Havel Prague
29h 01m
2 stops
DSM10:31 amDes Moines
$831
United Airlines
Sep 2
DSM3:20 pmDes Moines
23h 00m
2 stops
PRG9:20 pmVáclav Havel Prague
Sep 10
PRG6:00 amVáclav Havel Prague
21h 26m
2 stops
DSM8:26 pmDes Moines
$853
United Airlines
Sep 1
DSM8:00 amDes Moines
20h 00m
3 stops
PRG11:00 amVáclav Havel Prague
Sep 10
PRG6:00 amVáclav Havel Prague
18h 57m
2 stops
DSM5:57 pmDes Moines
$854

Delta flights from Des Moines to Prague

Our best Delta deals on Des Moines to Prague flight tickets
Delta
Sep 7
DSM5:30 pmDes Moines
14h 30m
2 stops
PRG3:00 pmVáclav Havel Prague
Sep 14
PRG2:30 pmVáclav Havel Prague
30h 36m
2 stops
DSM2:06 pmDes Moines
$851
Delta
Sep 1
DSM7:15 amDes Moines
18h 05m
2 stops
PRG8:20 amVáclav Havel Prague
Sep 15
PRG11:00 amVáclav Havel Prague
16h 46m
2 stops
DSM8:46 pmDes Moines
$852
Delta
Aug 11
DSM6:00 amDes Moines
20h 00m
2 stops
PRG9:00 amVáclav Havel Prague
Aug 26
PRG11:00 amVáclav Havel Prague
16h 39m
2 stops
DSM8:39 pmDes Moines
$885

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/8

3:22 pm-5:50 pm

2 stops19h 28m

Václav Havel Prague

Tue 9/15

6:10 am-9:28 pm

2 stops22h 18m

$825

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/9

6:22 pm-5:05 pm

2 stops15h 43m

Václav Havel Prague

Wed 9/16

10:15 am-9:36 pm

1 stop18h 21m

$828

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/1

8:00 am-11:00 am

3 stops20h 00m

Václav Havel Prague

Wed 9/16

12:30 pm-10:31 am

2 stops29h 01m

$831

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/9

5:56 pm-5:05 pm

2 stops16h 09m

Václav Havel Prague

Wed 9/16

10:15 am-9:36 pm

1 stop18h 21m

$834
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/8

1:08 pm-11:30 am

2 stops15h 22m

Václav Havel Prague

Tue 9/15

10:15 am-9:36 pm

1 stop18h 21m

$836

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/8

5:41 am-8:15 am

1 stop19h 34m

Václav Havel Prague

Tue 9/15

10:15 am-9:36 pm

1 stop18h 21m

$839

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/8

1:08 pm-11:30 am

2 stops15h 22m

Václav Havel Prague

Tue 9/15

10:15 am-12:04 am

2 stops20h 49m

$840

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/9

4:11 pm-3:00 pm

2 stops15h 49m

Václav Havel Prague

Wed 9/16

6:00 am-5:19 pm

2 stops18h 19m

$843

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 9/7

5:30 pm-3:00 pm

2 stops14h 30m

Václav Havel Prague

Mon 9/14

2:30 pm-2:06 pm

2 stops30h 36m

$851

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 9/1

7:15 am-8:20 am

2 stops18h 05m

Václav Havel Prague

Tue 9/15

11:00 am-8:46 pm

2 stops16h 46m

$852

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 05m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 05m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Fri 8/28
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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588