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Cheap flights from Des Moines to Prague from $353

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 12/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
1:21 pm - 8:55 am
DSM
-
PRG
12h 34m
2 stops
Lufthansa Logo
6:10 am - 5:28 pm
PRG
-
DSM
18h 18m
2 stops
$801Lufthansa
Wed, Aug 26 - Wed, Sep 2
Lufthansa Logo
3:20 pm - 5:40 pm
DSM
-
PRG
19h 20m
2 stops
Lufthansa Logo
4:40 pm - 9:23 pm
PRG
-
DSM
35h 43m
2 stops
$821Lufthansa
Mon, Aug 24 - Mon, Aug 31
American Airlines Logo
6:22 pm - 5:05 pm
DSM
-
PRG
15h 43m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$825American Airlines
Wed, Aug 26 - Wed, Sep 2
American Airlines Logo
6:22 pm - 5:05 pm
DSM
-
PRG
15h 43m
2 stops
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$826American Airlines
Wed, Aug 26 - Wed, Sep 2
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 12:34 pm
PRG
-
DSM
33h 19m
1 stop
$827American Airlines
Tue, Aug 25 - Tue, Sep 1
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 12:34 pm
PRG
-
DSM
33h 19m
1 stop
$829American Airlines
Tue, Aug 25 - Tue, Sep 1
American Airlines Logo
5:40 am - 8:15 am
DSM
-
PRG
19h 35m
1 stop
American Airlines Logo
10:15 am - 10:06 pm
PRG
-
DSM
18h 51m
1 stop
$833American Airlines
Tue, Aug 25 - Tue, Sep 1
American Airlines Logo
1:07 pm - 8:15 am
DSM
-
PRG
12h 08m
1 stop
American Airlines Logo
10:15 am - 12:20 am
PRG
-
DSM
21h 05m
2 stops
$837American Airlines
Tue, Aug 25 - Tue, Sep 1
Multiple Airlines Logo
10:26 am - 8:15 am
DSM
-
PRG
14h 49m
2 stops
Multiple Airlines Logo
10:15 am - 7:19 pm
PRG
-
DSM
16h 04m
2 stops
$841Multiple Airlines
Fri, Aug 21 - Fri, Aug 28
KLM Logo
5:30 pm - 5:40 pm
DSM
-
PRG
17h 10m
2 stops
KLM Logo
8:20 pm - 2:04 pm
PRG
-
DSM
24h 44m
2 stops
$844KLM
Mon, Aug 24 - Mon, Aug 31

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KLM flights from Des Moines to Prague

Our best KLM deals on Des Moines to Prague flight tickets
KLM
Aug 24
DSM5:30 pmDes Moines
17h 10m
2 stops
PRG5:40 pmVáclav Havel Prague
Aug 31
PRG8:20 pmVáclav Havel Prague
24h 44m
2 stops
DSM2:04 pmDes Moines
$844
KLM
Aug 24
DSM5:56 pmDes Moines
12h 49m
2 stops
PRG1:45 pmVáclav Havel Prague
Aug 31
PRG8:20 pmVáclav Havel Prague
25h 56m
2 stops
DSM3:16 pmDes Moines
$946

Air Canada flights from Des Moines to Prague

Our best Air Canada deals on Des Moines to Prague flight tickets
Air Canada
Aug 24
DSM5:21 pmDes Moines
34h 29m
2 stops
PRG10:50 amVáclav Havel Prague
Aug 31
PRG12:30 pmVáclav Havel Prague
28h 56m
2 stops
DSM10:26 amDes Moines
$851
Air Canada
Aug 25
DSM8:00 amDes Moines
17h 30m
3 stops
PRG8:30 amVáclav Havel Prague
Sep 1
PRG6:10 amVáclav Havel Prague
22h 13m
3 stops
DSM9:23 pmDes Moines
$1,043
Air Canada
Aug 25
DSM8:00 amDes Moines
17h 30m
3 stops
PRG8:30 amVáclav Havel Prague
Sep 1
PRG6:10 amVáclav Havel Prague
22h 13m
3 stops
DSM9:23 pmDes Moines
$1,047

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 14, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/26

1:21 pm-8:55 am

2 stops12h 34m

Václav Havel Prague

Wed 9/2

6:10 am-5:28 pm

2 stops18h 18m

$801

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/24

3:20 pm-5:40 pm

2 stops19h 20m

Václav Havel Prague

Mon 8/31

4:40 pm-9:23 pm

2 stops35h 43m

$821

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/26

6:22 pm-5:05 pm

2 stops15h 43m

Václav Havel Prague

Wed 9/2

10:15 am-10:06 pm

1 stop18h 51m

$825

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 8/26

6:22 pm-5:05 pm

2 stops15h 43m

Václav Havel Prague

Wed 9/2

10:15 am-10:06 pm

1 stop18h 51m

$826

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/25

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 9/1

10:15 am-12:34 pm

1 stop33h 19m

$827

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/25

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 9/1

10:15 am-12:34 pm

1 stop33h 19m

$829

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/25

5:40 am-8:15 am

1 stop19h 35m

Václav Havel Prague

Tue 9/1

10:15 am-10:06 pm

1 stop18h 51m

$833

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 8/25

1:07 pm-8:15 am

1 stop12h 08m

Václav Havel Prague

Tue 9/1

10:15 am-12:20 am

2 stops21h 05m

$837

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/21

10:26 am-8:15 am

2 stops14h 49m

Václav Havel Prague

Fri 8/28

10:15 am-7:19 pm

2 stops16h 04m

$841

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 8/24

5:30 pm-5:40 pm

2 stops17h 10m

Václav Havel Prague

Mon 8/31

8:20 pm-2:04 pm

2 stops24h 44m

$844

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Prague from

How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

14h 57m

Direct flights

None
The fastest flight from Des Moines to Prague takes 14h 57m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 14h 57m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588