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Cheap flights from Des Moines to Prague from $382

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:30 am - 1:05 pmDSM  Des Moines-PRG Václav Havel Prague
18h 35m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss
United Airlines Logo
11:30 am - 10:30 pmPRG  Václav Havel Prague-DSM Des Moines
18h 00m2 stops Frankfurt am Main Houston George Bush Intcntl
$739United Airlines
Mon, Jan 11 - Wed, Jan 13
United Airlines Logo
6:15 am - 10:45 amDSM  Des Moines-PRG Václav Havel Prague
21h 30m3 stops Chicago O'Hare Intl Newark Frankfurt am Main
United Airlines Logo
7:05 am - 9:17 pmPRG  Václav Havel Prague-DSM Des Moines
21h 12m2 stops Frankfurt am Main Chicago O'Hare Intl
$752United Airlines
Mon, Jan 11 - Wed, Jan 13
American Airlines Logo
5:56 pm - 3:45 pmDSM  Des Moines-PRG Václav Havel Prague
14h 49m2 stops Chicago O'Hare Intl London Heathrow
American Airlines Logo
10:15 am - 12:31 pmPRG  Václav Havel Prague-DSM Des Moines
33h 16m1 stop Philadelphia
$876American Airlines
Wed, Sep 23 - Wed, Sep 30
American Airlines Logo
6:00 am - 8:15 amDSM  Des Moines-PRG Václav Havel Prague
19h 15m1 stop Philadelphia
American Airlines Logo
10:15 am - 9:36 pmPRG  Václav Havel Prague-DSM Des Moines
18h 21m1 stop Philadelphia
$879American Airlines
Wed, Sep 23 - Wed, Sep 30
American Airlines Logo
6:00 am - 8:15 amDSM  Des Moines-PRG Václav Havel Prague
19h 15m1 stop Philadelphia
American Airlines Logo
10:15 am - 9:36 pmPRG  Václav Havel Prague-DSM Des Moines
18h 21m1 stop Philadelphia
$883American Airlines
Tue, Sep 22 - Tue, Sep 29
American Airlines Logo
7:05 am - 8:15 amDSM  Des Moines-PRG Václav Havel Prague
18h 10m2 stops Chicago O'Hare Intl Philadelphia
American Airlines Logo
10:15 am - 9:36 pmPRG  Václav Havel Prague-DSM Des Moines
18h 21m1 stop Philadelphia
$888American Airlines
Tue, Sep 22 - Tue, Sep 29
Multiple Airlines Logo
5:35 pm - 3:00 pmDSM  Des Moines-PRG Václav Havel Prague
14h 25m2 stops Detroit Metropolitan Wayne County Paris Charles de Gaulle
Multiple Airlines Logo
6:00 am - 5:19 pmPRG  Václav Havel Prague-DSM Des Moines
18h 19m2 stops Amsterdam Schiphol Detroit Metropolitan Wayne County
$891Multiple Airlines
Wed, Sep 23 - Wed, Sep 30
Lufthansa Logo
6:55 pm - 8:55 amDSM  Des Moines-PRG Václav Havel Prague
31h 00m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss
Lufthansa Logo
6:10 am - 5:48 pmPRG  Václav Havel Prague-DSM Des Moines
18h 38m2 stops Frankfurt am Main Chicago O'Hare Intl
$900Lufthansa
Sun, Sep 27 - Sun, Oct 4
Multiple Airlines Logo
11:27 am - 10:50 amDSM  Des Moines-PRG Václav Havel Prague
16h 23m2 stops Chicago O'Hare Intl Toronto Pearson Intl
Multiple Airlines Logo
6:00 am - 9:23 pmPRG  Václav Havel Prague-DSM Des Moines
22h 23m2 stops Frankfurt am Main Chicago O'Hare Intl
$929Multiple Airlines
Fri, Sep 25 - Fri, Oct 2
Multiple Airlines Logo
11:27 am - 10:50 amDSM  Des Moines-PRG Václav Havel Prague
16h 23m2 stops Chicago O'Hare Intl Toronto Pearson Intl
Multiple Airlines Logo
6:00 am - 2:15 pmPRG  Václav Havel Prague-DSM Des Moines
15h 15m2 stops Frankfurt am Main Chicago O'Hare Intl
$930Multiple Airlines
Fri, Sep 25 - Fri, Oct 2

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United Airlines flights from Des Moines to Prague

Our best United Airlines deals on Des Moines to Prague flight tickets
United Airlines
Jan 11
DSM11:30 amDes Moines
18h 35m
2 stops
PRG1:05 pmVáclav Havel Prague
Jan 13
PRG11:30 amVáclav Havel Prague
18h 00m
2 stops
DSM10:30 pmDes Moines
$739
United Airlines
Jan 11
DSM6:15 amDes Moines
21h 30m
3 stops
PRG10:45 amVáclav Havel Prague
Jan 13
PRG7:05 amVáclav Havel Prague
21h 12m
2 stops
DSM9:17 pmDes Moines
$752
United Airlines
Sep 2
DSM3:20 pmDes Moines
17h 40m
2 stops
PRG4:00 pmVáclav Havel Prague
Sep 15
PRG9:10 amVáclav Havel Prague
20h 20m
2 stops
DSM10:30 pmDes Moines
$944

Lufthansa flights from Des Moines to Prague

Our best Lufthansa deals on Des Moines to Prague flight tickets
Lufthansa
Sep 27
DSM6:55 pmDes Moines
31h 00m
2 stops
PRG8:55 amVáclav Havel Prague
Oct 4
PRG6:10 amVáclav Havel Prague
18h 38m
2 stops
DSM5:48 pmDes Moines
$900
Lufthansa
Sep 27
DSM6:55 pmDes Moines
19h 25m
2 stops
PRG9:20 pmVáclav Havel Prague
Oct 4
PRG6:10 amVáclav Havel Prague
24h 25m
2 stops
DSM11:35 pmDes Moines
$949
Lufthansa
Sep 26
DSM6:55 pmDes Moines
31h 00m
2 stops
PRG8:55 amVáclav Havel Prague
Oct 3
PRG6:40 pmVáclav Havel Prague
30h 08m
2 stops
DSM5:48 pmDes Moines
$961

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Mon 1/11

11:30 am-1:05 pm

2 stops18h 35m

Václav Havel Prague

Wed 1/13

11:30 am-10:30 pm

2 stops18h 00m

$739

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Mon 1/11

6:15 am-10:45 am

3 stops21h 30m

Václav Havel Prague

Wed 1/13

7:05 am-9:17 pm

2 stops21h 12m

$752

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Wed 9/23

5:56 pm-3:45 pm

2 stops14h 49m

Václav Havel Prague

Wed 9/30

10:15 am-12:31 pm

1 stop33h 16m

$876

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Wed 9/23

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Wed 9/30

10:15 am-9:36 pm

1 stop18h 21m

$879

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/22

6:00 am-8:15 am

1 stop19h 15m

Václav Havel Prague

Tue 9/29

10:15 am-9:36 pm

1 stop18h 21m

$883

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Tue 9/22

7:05 am-8:15 am

2 stops18h 10m

Václav Havel Prague

Tue 9/29

10:15 am-9:36 pm

1 stop18h 21m

$888

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Wed 9/23

5:35 pm-3:00 pm

2 stops14h 25m

Václav Havel Prague

Wed 9/30

6:00 am-5:19 pm

2 stops18h 19m

$891

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Sun 9/27

6:55 pm-8:55 am

2 stops31h 00m

Václav Havel Prague

Sun 10/4

6:10 am-5:48 pm

2 stops18h 38m

$900

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Fri 9/25

11:27 am-10:50 am

2 stops16h 23m

Václav Havel Prague

Fri 10/2

6:00 am-9:23 pm

2 stops22h 23m

$929
Quickest round-trip

Des MoinesPrague

DSM Des Moines - PRG Václav Havel Prague

DSMPRG

Des Moines

Fri 9/25

11:27 am-10:50 am

2 stops16h 23m

Václav Havel Prague

Fri 10/2

6:00 am-2:15 pm

2 stops15h 15m

$930

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 30% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

18h 35m

Direct flights

None
The fastest flight from Des Moines to Prague takes 18h 35m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
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Frequently asked questions about flying from Des Moines to Prague

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 18h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cabin classes currently available on flights to Prague

List of cabin classes available on flights landing in Prague. Availability may vary depending on flight origin and airline.
First Class to Prague
Business Class to Praguefrom $3,588