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Cheap flights from Des Moines to Prague from $509

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Prague departing on 4/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Prague

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:40 am - 8:55 am
DSM
-
PRG
14h 15m
2 stops
United Airlines Logo
9:10 am - 10:45 pm
PRG
-
DSM
20h 35m
2 stops
$611United Airlines
Fri, May 1 - Sun, May 10
Lufthansa Logo
8:10 pm - 11:10 pm
DSM
-
PRG
20h 00m
2 stops
Lufthansa Logo
2:10 pm - 11:09 pm
PRG
-
DSM
15h 59m
2 stops
$634Lufthansa
Fri, May 1 - Sun, May 10
Scandinavian Airlines Logo
2:15 pm - 9:40 am
DSM
-
PRG
36h 25m
2 stops
Scandinavian Airlines Logo
3:20 pm - 10:26 pm
PRG
-
DSM
38h 06m
2 stops
$655Scandinavian Airlines
Sun, Aug 16 - Wed, Sep 2
United Airlines Logo
8:00 am - 4:05 pm
DSM
-
PRG
25h 05m
3 stops
United Airlines Logo
7:25 am - 8:40 pm
PRG
-
DSM
20h 15m
2 stops
$711United Airlines
Wed, Mar 4 - Sun, Mar 8
Multiple Airlines Logo
3:21 pm - 12:45 pm
DSM
-
PRG
14h 24m
2 stops
Multiple Airlines Logo
6:10 am - 2:25 pm
PRG
-
DSM
15h 15m
2 stops
$730Multiple Airlines
Tue, Apr 7 - Tue, Apr 14
Multiple Airlines Logo
3:27 pm - 4:05 pm
DSM
-
PRG
17h 38m
2 stops
Multiple Airlines Logo
6:10 am - 2:25 pm
PRG
-
DSM
15h 15m
2 stops
$731Multiple Airlines
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
5:47 pm - 3:00 pm
DSM
-
PRG
14h 13m
2 stops
Multiple Airlines Logo
11:15 am - 8:39 pm
PRG
-
DSM
16h 24m
2 stops
$748Multiple Airlines
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
5:47 pm - 3:00 pm
DSM
-
PRG
14h 13m
2 stops
Multiple Airlines Logo
6:00 am - 5:02 pm
PRG
-
DSM
18h 02m
2 stops
$749Multiple Airlines
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
5:47 pm - 3:00 pm
DSM
-
PRG
14h 13m
2 stops
Multiple Airlines Logo
6:00 am - 3:41 pm
PRG
-
DSM
16h 41m
2 stops
$750Multiple Airlines
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
5:47 pm - 3:00 pm
DSM
-
PRG
14h 13m
2 stops
Multiple Airlines Logo
11:15 am - 8:39 pm
PRG
-
DSM
16h 24m
2 stops
$752Multiple Airlines
Wed, Apr 8 - Wed, Apr 15

Scandinavian Airlines flights from Des Moines to Prague

Our best Scandinavian Airlines deals on Des Moines to Prague flight tickets
Scandinavian Airlines
Aug 16
DSM2:15 pmDes Moines
36h 25m
2 stops
PRG9:40 amVáclav Havel Prague
Sep 3
PRG3:20 pmVáclav Havel Prague
38h 06m
2 stops
DSM10:26 pmDes Moines
$655
Scandinavian Airlines
Aug 16
DSM2:15 pmDes Moines
36h 25m
2 stops
PRG9:40 amVáclav Havel Prague
Aug 30
PRG9:30 pmVáclav Havel Prague
31h 56m
2 stops
DSM10:26 pmDes Moines
$825
Scandinavian Airlines
Aug 16
DSM2:15 pmDes Moines
36h 25m
2 stops
PRG9:40 amVáclav Havel Prague
Aug 29
PRG8:55 pmVáclav Havel Prague
32h 31m
2 stops
DSM10:26 pmDes Moines
$875

Delta flights from Des Moines to Prague

Our best Delta deals on Des Moines to Prague flight tickets
Delta
Apr 7
DSM6:15 amDes Moines
21h 15m
2 stops
PRG10:30 amVáclav Havel Prague
Apr 14
PRG2:30 pmVáclav Havel Prague
32h 11m
2 stops
DSM3:41 pmDes Moines
$762
Delta
Apr 6
DSM10:51 amDes Moines
19h 54m
2 stops
PRG1:45 pmVáclav Havel Prague
Apr 13
PRG2:30 pmVáclav Havel Prague
32h 11m
2 stops
DSM3:41 pmDes Moines
$763
Delta
Aug 17
DSM5:45 amDes Moines
20h 15m
2 stops
PRG9:00 amVáclav Havel Prague
Sep 1
PRG11:00 amVáclav Havel Prague
29h 19m
2 stops
DSM9:19 amDes Moines
$804

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

11:40 am-8:55 am

2 stops14h 15m

Václav Havel Prague

Sun 5/10

9:10 am-10:45 pm

2 stops20h 35m

$611

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

8:10 pm-11:10 pm

2 stops20h 00m

Václav Havel Prague

Sun 5/10

2:10 pm-11:09 pm

2 stops15h 59m

$634

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 8/16

2:15 pm-9:40 am

2 stops36h 25m

Václav Havel Prague

Wed 9/2

3:20 pm-10:26 pm

2 stops38h 06m

$655

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

8:00 am-4:05 pm

3 stops25h 05m

Václav Havel Prague

Sun 3/8

7:25 am-8:40 pm

2 stops20h 15m

$711

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 4/7

3:21 pm-12:45 pm

2 stops14h 24m

Václav Havel Prague

Tue 4/14

6:10 am-2:25 pm

2 stops15h 15m

$730

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

3:27 pm-4:05 pm

2 stops17h 38m

Václav Havel Prague

Wed 4/15

6:10 am-2:25 pm

2 stops15h 15m

$731

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

5:47 pm-3:00 pm

2 stops14h 13m

Václav Havel Prague

Wed 4/15

11:15 am-8:39 pm

2 stops16h 24m

$748

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

5:47 pm-3:00 pm

2 stops14h 13m

Václav Havel Prague

Wed 4/15

6:00 am-5:02 pm

2 stops18h 02m

$749

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

5:47 pm-3:00 pm

2 stops14h 13m

Václav Havel Prague

Wed 4/15

6:00 am-3:41 pm

2 stops16h 41m

$750

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

5:47 pm-3:00 pm

2 stops14h 13m

Václav Havel Prague

Wed 4/15

11:15 am-8:39 pm

2 stops16h 24m

$752

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Prague

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Prague flights?

You could potentially save up to 46% on your flight if you consider stops on a Des Moines to Prague flight.

When to book flights from Des Moines to Prague

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Prague according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Prague (DSM to PRG) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Prague

Fastest flight time

16h 53m

Direct flights

None
The fastest flight from Des Moines to Prague takes 16h 53m
There are no direct flights from Des Moines to Prague. There are no popular flight routes from Des Moines to Prague.
Search flight deals

  • How far is Des Moines to Václav Havel Prague by plane?

    A flight from Des Moines to Václav Havel Prague will travel around 4755.3 mi. Flights usually cover this in 16h 53m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Václav Havel Prague Airport?

    Prices for flights from Des Moines Airport to Václav Havel Prague Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Václav Havel Prague Airport?

  • How old do you have to be to fly from Des Moines Airport to Václav Havel Prague Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Václav Havel Prague Airport.

  • What documentation or ID do you need to fly to Václav Havel Prague Airport?

    The travel and health documents required for your trip to Václav Havel Prague Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Václav Havel Prague Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Prague?

Best airlines flying from Des Moines to Prague

Compare and see reviews for airlines that fly from Des Moines to Prague with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,342 reviews
Search United Airlines flights

Traveling to a place near Prague?

Book flights to Prague if you plan to visit one of these locations
Český Krumlov
Pilsen
Liberec

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Prague?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Prague from Des Moines.

Can I find flights from Des Moines to Prague with flexible booking policies on momondo?

momondo does allow users to show only those flights to Prague from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Prague?

momondo provides multiple filters to help you find the best flight to Prague from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Prague right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Prague from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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