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Cheap flights from Des Moines to Guadalajara from $326

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guadalajara departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Guadalajara

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:01 pm - 4:22 pm
DSM
-
GDL
19h 21m
1 stop
Multiple Airlines Logo
8:00 pm - 2:19 pm
GDL
-
DSM
41h 19m
2 stops
$457Multiple Airlines
Fri, May 8 - Tue, May 26
Multiple Airlines Logo
10:01 pm - 4:22 pm
DSM
-
GDL
19h 21m
1 stop
Multiple Airlines Logo
8:25 pm - 2:19 pm
GDL
-
DSM
40h 54m
3 stops
$483Multiple Airlines
Fri, May 8 - Tue, May 26
Multiple Airlines Logo
8:21 pm - 10:20 pm
DSM
-
GDL
26h 59m
2 stops
Multiple Airlines Logo
8:15 am - 2:31 pm
GDL
-
DSM
29h 16m
1 stop
$513Multiple Airlines
Sat, Mar 28 - Sat, Apr 4
Aeromexico Logo
7:00 am - 4:50 pm
DSM
-
GDL
10h 50m
2 stops
Aeromexico Logo
9:50 pm - 5:45 pm
GDL
-
DSM
18h 55m
2 stops
$536Aeromexico
Tue, Apr 14 - Tue, Apr 21
American Airlines Logo
6:13 pm - 12:29 pm
DSM
-
GDL
19h 16m
1 stop
American Airlines Logo
1:29 pm - 11:16 pm
GDL
-
DSM
8h 47m
1 stop
$539American Airlines
Tue, Apr 14 - Tue, Apr 21
American Airlines Logo
3:20 pm - 12:29 pm
DSM
-
GDL
22h 09m
1 stop
American Airlines Logo
1:29 pm - 11:26 am
GDL
-
DSM
20h 57m
1 stop
$541American Airlines
Tue, Apr 14 - Tue, Apr 21
Multiple Airlines Logo
8:21 pm - 4:06 pm
DSM
-
GDL
20h 45m
1 stop
Multiple Airlines Logo
8:15 am - 2:31 pm
GDL
-
DSM
29h 16m
1 stop
$551Multiple Airlines
Sat, Mar 28 - Sat, Apr 4
Multiple Airlines Logo
11:00 am - 6:30 pm
DSM
-
GDL
8h 30m
1 stop
Multiple Airlines Logo
5:50 am - 1:29 pm
GDL
-
DSM
30h 39m
2 stops
$554Multiple Airlines
Sun, May 3 - Sun, May 10
Frontier Logo
8:21 pm - 4:20 pm
DSM
-
GDL
20h 59m
1 stop
Frontier Logo
8:02 am - 7:26 pm
GDL
-
DSM
10h 24m
1 stop
$555Frontier
Wed, Jun 10 - Wed, Jun 17
American Airlines Logo
5:00 am - 12:29 pm
DSM
-
GDL
8h 29m
1 stop
American Airlines Logo
1:29 pm - 11:16 pm
GDL
-
DSM
8h 47m
1 stop
$584American Airlines
Tue, Apr 14 - Tue, Apr 21

American Airlines flights from Des Moines to Guadalajara

Our best American Airlines deals on Des Moines to Guadalajara flight tickets
American Airlines
Apr 14
DSM6:13 pmDes Moines
19h 16m
1 stop
GDL12:29 pmGuadalajara Miguel Hidal
Apr 21
GDL1:29 pmGuadalajara Miguel Hidal
8h 47m
1 stop
DSM11:16 pmDes Moines
$539
American Airlines
Apr 14
DSM3:20 pmDes Moines
22h 09m
1 stop
GDL12:29 pmGuadalajara Miguel Hidal
Apr 21
GDL1:29 pmGuadalajara Miguel Hidal
20h 57m
1 stop
DSM11:26 amDes Moines
$541
American Airlines
Apr 14
DSM5:00 amDes Moines
8h 29m
1 stop
GDL12:29 pmGuadalajara Miguel Hidal
Apr 21
GDL1:29 pmGuadalajara Miguel Hidal
8h 47m
1 stop
DSM11:16 pmDes Moines
$584

Frontier flights from Des Moines to Guadalajara

Our best Frontier deals on Des Moines to Guadalajara flight tickets
Frontier
Jun 10
DSM8:21 pmDes Moines
20h 59m
1 stop
GDL4:20 pmGuadalajara Miguel Hidal
Jun 17
GDL8:02 amGuadalajara Miguel Hidal
10h 24m
1 stop
DSM7:26 pmDes Moines
$555
Frontier
Mar 16
DSM8:21 pmDes Moines
20h 04m
1 stop
GDL3:25 pmGuadalajara Miguel Hidal
Mar 18
GDL6:10 amGuadalajara Miguel Hidal
9h 46m
1 stop
DSM4:56 pmDes Moines
$577
Frontier
Mar 16
DSM11:00 amDes Moines
18h 42m
2 stops
GDL4:42 amGuadalajara Miguel Hidal
Mar 18
GDL7:02 amGuadalajara Miguel Hidal
11h 14m
1 stop
DSM7:16 pmDes Moines
$585

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guadalajara that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 3, 2026.
Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 5/8

10:01 pm-4:22 pm

1 stop19h 21m

Guadalajara Miguel Hidal

Tue 5/26

8:00 pm-2:19 pm

2 stops41h 19m

$457

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 5/8

10:01 pm-4:22 pm

1 stop19h 21m

Guadalajara Miguel Hidal

Tue 5/26

8:25 pm-2:19 pm

3 stops40h 54m

$483

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sat 3/28

8:21 pm-10:20 pm

2 stops26h 59m

Guadalajara Miguel Hidal

Sat 4/4

8:15 am-2:31 pm

1 stop29h 16m

$513

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 4/14

7:00 am-4:50 pm

2 stops10h 50m

Guadalajara Miguel Hidal

Tue 4/21

9:50 pm-5:45 pm

2 stops18h 55m

$536

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 4/14

6:13 pm-12:29 pm

1 stop19h 16m

Guadalajara Miguel Hidal

Tue 4/21

1:29 pm-11:16 pm

1 stop8h 47m

$539

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 4/14

3:20 pm-12:29 pm

1 stop22h 09m

Guadalajara Miguel Hidal

Tue 4/21

1:29 pm-11:26 am

1 stop20h 57m

$541

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sat 3/28

8:21 pm-4:06 pm

1 stop20h 45m

Guadalajara Miguel Hidal

Sat 4/4

8:15 am-2:31 pm

1 stop29h 16m

$551

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 5/3

11:00 am-6:30 pm

1 stop8h 30m

Guadalajara Miguel Hidal

Sun 5/10

5:50 am-1:29 pm

2 stops30h 39m

$554

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 6/10

8:21 pm-4:20 pm

1 stop20h 59m

Guadalajara Miguel Hidal

Wed 6/17

8:02 am-7:26 pm

1 stop10h 24m

$555

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 4/14

5:00 am-12:29 pm

1 stop8h 29m

Guadalajara Miguel Hidal

Tue 4/21

1:29 pm-11:16 pm

1 stop8h 47m

$584

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Guadalajara from

How to get the cheapest flight ticket from Des Moines to Guadalajara

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Guadalajara?

What is the cheapest month to fly to Guadalajara?

The cheapest month to fly to Guadalajara from Des Moines is in May. Flight prices, which tend to average around $535, are often lower during this time because this is during the off-season. If you’re not able to fly to Guadalajara in May, then April is your next best option. Flight prices from Des Moines to Guadalajara during April average around $568.

How have Des Moines to Guadalajara flight prices changed over time?

As of March 2026, prices for Des Moines to Guadalajara flights are approximately 25% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Guadalajara

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guadalajara according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guadalajara (DSM to GDL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guadalajara

Fastest flight time

6h 14m

Direct flights

None
The fastest flight from Des Moines to Guadalajara takes 6h 14m
There are no direct flights from Des Moines to Guadalajara. There are no popular flight routes from Des Moines to Guadalajara.
Search flight deals

  • How far is Des Moines to Guadalajara Miguel Hidal by plane?

    The distance between Des Moines and Guadalajara Miguel Hidal is about 1552.3 mi. In terms of flight time, this usually takes a little over 6h 14m.

  • When did momondo last update prices for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport?

    Prices for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport?

  • How old do you have to be to fly from Des Moines Airport to Guadalajara Miguel Hidal Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guadalajara Miguel Hidal Airport.

  • What documentation or ID do you need to fly to Guadalajara Miguel Hidal Airport?

    The travel and health documents required for your trip to Guadalajara Miguel Hidal Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guadalajara Miguel Hidal Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Guadalajara?

Best airlines flying from Des Moines to Guadalajara

Compare and see reviews for airlines that fly from Des Moines to Guadalajara with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $536Free CancellationRating
7.1
11,375 reviews
Search American Airlines flights
United AirlinesPriceFrom $563Free CancellationRating
7.4
9,377 reviews
Search United Airlines flights

Traveling to a place near Guadalajara?

Book flights to Guadalajara if you plan to visit one of these locations
Tequila
Ajijic
Zapopan
Tlaquepaque

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guadalajara?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Guadalajara for you.

Can I find flights from Des Moines to Guadalajara with flexible booking policies on momondo?

Yes. All flights to Guadalajara from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Guadalajara?

Once all potential Des Moines to Guadalajara flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Guadalajara right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Guadalajara, momondo offers a useful price alert feature which will track prices for flights to Guadalajara from Des Moines and alert you when they change.

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