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Cheap flights from Des Moines to Guadalajara from $179

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guadalajara departing on 12/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Guadalajara

Cheap round-trip flights

Multiple Airlines Logo
2:37 pm - 3:05 pmDSM-GDL
25h 28m1 stop
Multiple Airlines Logo
6:00 am - 1:52 pmGDL-DSM
30h 52m2 stops
$384Multiple Airlines
Find Deal
Wed, Oct 8 - Tue, Oct 21
Multiple Airlines Logo
2:37 pm - 3:05 pmDSM-GDL
25h 28m1 stop
Multiple Airlines Logo
6:00 am - 1:52 pmGDL-DSM
30h 52m2 stops
$403Multiple Airlines
Find Deal
Sun, Oct 12 - Tue, Oct 21
Multiple Airlines Logo
3:40 pm - 5:08 pmDSM-GDL
26h 28m1 stop
Multiple Airlines Logo
6:00 am - 1:52 pmGDL-DSM
30h 52m2 stops
$414Multiple Airlines
Find Deal
Mon, Oct 13 - Tue, Oct 21
Multiple Airlines Logo
2:25 pm - 3:05 pmDSM-GDL
25h 40m1 stop
Multiple Airlines Logo
6:00 am - 1:52 pmGDL-DSM
30h 52m2 stops
$417Multiple Airlines
Find Deal
Fri, Oct 3 - Tue, Oct 14
Multiple Airlines Logo
2:37 pm - 3:05 pmDSM-GDL
25h 28m1 stop
Multiple Airlines Logo
10:20 am - 3:44 pmGDL-DSM
28h 24m2 stops
$418Multiple Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
Multiple Airlines Logo
2:32 pm - 1:21 pmDSM-GDL
22h 49m2 stops
Multiple Airlines Logo
8:02 am - 1:49 pmGDL-DSM
29h 47m1 stop
$420Multiple Airlines
Find Deal
Thu, Nov 6 - Thu, Nov 13
Multiple Airlines Logo
7:30 am - 8:15 pmDSM-GDL
13h 45m1 stop
Multiple Airlines Logo
6:00 am - 1:52 pmGDL-DSM
30h 52m2 stops
$421Multiple Airlines
Find Deal
Wed, Oct 1 - Tue, Oct 14
Multiple Airlines Logo
2:37 pm - 3:05 pmDSM-GDL
25h 28m1 stop
Multiple Airlines Logo
10:20 am - 10:37 pmGDL-DSM
11h 17m1 stop
$428Multiple Airlines
Find Deal
Wed, Oct 8 - Fri, Oct 17
Delta Logo
6:39 pm - 3:30 pmDSM-GDL
21h 51m2 stops
Delta Logo
9:23 am - 10:05 amGDL-DSM
23h 42m2 stops
$536Delta
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Tue, Oct 14 - Tue, Oct 21
American Airlines Logo
5:00 am - 9:55 amDSM-GDL
5h 55m1 stop
American Airlines Logo
7:00 am - 3:03 pmGDL-DSM
7h 03m1 stop
$550American Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21

Delta flights from Des Moines to Guadalajara

Our best Delta deals on Des Moines to Guadalajara flight tickets
Delta
Oct 14
DSM6:39 pmDes Moines
21h 51m
2 stops
GDL3:30 pmGuadalajara Miguel Hidal
Oct 21
GDL9:23 amGuadalajara Miguel Hidal
23h 42m
2 stops
DSM10:05 amDes Moines
$536
Find similar
Delta
Sep 30
DSM5:44 amDes Moines
6h 45m
1 stop
GDL11:29 amGuadalajara Miguel Hidal
Oct 16
GDL1:02 pmGuadalajara Miguel Hidal
20h 24m
2 stops
DSM10:26 amDes Moines
$646
Find similar
Delta
Sep 30
DSM5:44 amDes Moines
6h 45m
1 stop
GDL11:29 amGuadalajara Miguel Hidal
Oct 17
GDL1:02 pmGuadalajara Miguel Hidal
19h 17m
2 stops
DSM9:19 amDes Moines
$666
Find similar

American Airlines flights from Des Moines to Guadalajara

Our best American Airlines deals on Des Moines to Guadalajara flight tickets
American Airlines
Oct 14
DSM5:00 amDes Moines
5h 55m
1 stop
GDL9:55 amGuadalajara Miguel Hidal
Oct 21
GDL7:00 amGuadalajara Miguel Hidal
7h 03m
1 stop
DSM3:03 pmDes Moines
$550
Find similar
American Airlines
Sep 30
DSM6:12 pmDes Moines
6h 12m
1 stop
GDL11:24 pmGuadalajara Miguel Hidal
Oct 14
GDL7:00 amGuadalajara Miguel Hidal
7h 03m
1 stop
DSM3:03 pmDes Moines
$711
Find similar
American Airlines
Sep 30
DSM6:12 pmDes Moines
6h 12m
1 stop
GDL11:24 pmGuadalajara Miguel Hidal
Oct 12
GDL7:00 amGuadalajara Miguel Hidal
7h 03m
1 stop
DSM3:03 pmDes Moines
$741
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guadalajara that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 10/8

2:37 pm-3:05 pm

1 stop25h 28m

Guadalajara Miguel Hidal

Tue 10/21

6:00 am-1:52 pm

2 stops30h 52m

$384

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 10/12

2:37 pm-3:05 pm

1 stop25h 28m

Guadalajara Miguel Hidal

Tue 10/21

6:00 am-1:52 pm

2 stops30h 52m

$403

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Mon 10/13

3:40 pm-5:08 pm

1 stop26h 28m

Guadalajara Miguel Hidal

Tue 10/21

6:00 am-1:52 pm

2 stops30h 52m

$414

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 10/3

2:25 pm-3:05 pm

1 stop25h 40m

Guadalajara Miguel Hidal

Tue 10/14

6:00 am-1:52 pm

2 stops30h 52m

$417

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 10/8

2:37 pm-3:05 pm

1 stop25h 28m

Guadalajara Miguel Hidal

Wed 10/15

10:20 am-3:44 pm

2 stops28h 24m

$418

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Thu 11/6

2:32 pm-1:21 pm

2 stops22h 49m

Guadalajara Miguel Hidal

Thu 11/13

8:02 am-1:49 pm

1 stop29h 47m

$420

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 10/1

7:30 am-8:15 pm

1 stop13h 45m

Guadalajara Miguel Hidal

Tue 10/14

6:00 am-1:52 pm

2 stops30h 52m

$421

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 10/8

2:37 pm-3:05 pm

1 stop25h 28m

Guadalajara Miguel Hidal

Fri 10/17

10:20 am-10:37 pm

1 stop11h 17m

$428

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 10/14

6:39 pm-3:30 pm

2 stops21h 51m

Guadalajara Miguel Hidal

Tue 10/21

9:23 am-10:05 am

2 stops23h 42m

$536

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 10/14

5:00 am-9:55 am

1 stop5h 55m

Guadalajara Miguel Hidal

Tue 10/21

7:00 am-3:03 pm

1 stop7h 03m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guadalajara from

How to get the cheapest flight ticket from Des Moines to Guadalajara

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Guadalajara?

The cheapest month to fly to Guadalajara from Des Moines is in April. Flight prices, which tend to average around $570, are often lower during this time because this is during the off-season. If you’re not able to fly to Guadalajara in April, then August is your next best option. Flight prices from Des Moines to Guadalajara during August average around $573.

What is the cheapest day to depart on your flight to Guadalajara?

Our data shows that Saturday is the least expensive day to fly to Guadalajara. Tickets to fly out on this day can be as low as $574. Flights from Des Moines to Guadalajara on a Friday will generally be more expensive and average around $773. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Guadalajara?

Flying to Guadalajara from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $605 when looking at flights departing in the morning. In contrast, the most expensive time of day to depart to Guadalajara is in the evening when prices are around $829.

How have Des Moines to Guadalajara flight prices changed over time?

When to book flights from Des Moines to Guadalajara

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guadalajara according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guadalajara (DSM to GDL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guadalajara

Direct flights

None
There are no direct flights from Des Moines to Guadalajara. There are no popular flight routes from Des Moines to Guadalajara.
Search flight deals

  • How far is Des Moines to Guadalajara Miguel Hidal by plane?

    The distance between Des Moines and Guadalajara Miguel Hidal is about 1552.3 mi. In terms of flight time, this usually takes a little over 5h 55m.

  • When did momondo last update prices for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport?

    Prices for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Guadalajara Miguel Hidal Airport?

  • How old do you have to be to fly from Des Moines Airport to Guadalajara Miguel Hidal Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guadalajara Miguel Hidal Airport.

  • What documentation or ID do you need to fly to Guadalajara Miguel Hidal Airport?

    The travel and health documents required for your trip to Guadalajara Miguel Hidal Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guadalajara Miguel Hidal Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Guadalajara?

Best airlines flying from Des Moines to Guadalajara

Compare and see reviews for airlines that fly from Des Moines to Guadalajara with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $459Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
American AirlinesPriceFrom $517Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Guadalajara?

Book flights to Guadalajara if you plan to visit one of these locations
Tequila
Ajijic
Zapopan
Tlaquepaque

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guadalajara?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Guadalajara for you.

Can I find flights from Des Moines to Guadalajara with flexible booking policies on momondo?

Yes. All flights to Guadalajara from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Guadalajara?

Once all potential Des Moines to Guadalajara flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Guadalajara right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Guadalajara, momondo offers a useful price alert feature which will track prices for flights to Guadalajara from Des Moines and alert you when they change.

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