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Cheap flights from Des Moines to Florence from $396

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florence departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Florence

Cheap round-trip flights

Multiple Airlines Logo
1:05 pm - 4:30 pmDSM-FLR
21h 25m2 stops
Multiple Airlines Logo
8:00 am - 8:45 pmFLR-DSM
19h 45m2 stops
$651Multiple Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Delta Logo
5:52 pm - 2:25 pmDSM-FLR
13h 33m2 stops
Delta Logo
9:50 am - 10:33 pmFLR-DSM
19h 43m2 stops
$654Delta
Find Deal
Fri, Nov 14 - Tue, Nov 18
United Airlines Logo
1:05 pm - 2:20 pmDSM-FLR
19h 15m2 stops
United Airlines Logo
2:15 pm - 12:14 pmFLR-DSM
28h 59m2 stops
$672United Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
United Airlines Logo
3:15 pm - 4:30 pmDSM-FLR
19h 15m2 stops
United Airlines Logo
2:15 pm - 2:19 pmFLR-DSM
31h 04m2 stops
$675United Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
British Airways Logo
6:20 pm - 11:20 amDSM-FLR
35h 00m2 stops
British Airways Logo
12:25 pm - 6:02 pmFLR-DSM
36h 37m2 stops
$691British Airways
Find Deal
Mon, Mar 9 - Sun, Mar 29
Lufthansa Logo
6:45 pm - 4:30 pmDSM-FLR
15h 45m2 stops
Lufthansa Logo
5:25 pm - 9:36 pmFLR-DSM
35h 11m2 stops
$693Lufthansa
Find Deal
Mon, Mar 9 - Sun, Mar 29
Lufthansa Logo
1:00 pm - 8:15 pmDSM-FLR
24h 15m2 stops
Lufthansa Logo
3:40 pm - 9:50 pmFLR-DSM
37h 10m2 stops
$790Lufthansa
Find Deal
Wed, Oct 15 - Sun, Oct 19
British Airways Logo
12:53 pm - 11:45 amDSM-FLR
16h 52m2 stops
British Airways Logo
12:25 pm - 6:02 pmFLR-DSM
36h 37m2 stops
$792British Airways
Find Deal
Thu, Mar 12 - Sun, Mar 29
American Airlines Logo
6:15 pm - 10:20 pmDSM-FLR
21h 05m3 stops
American Airlines Logo
12:25 pm - 10:40 pmFLR-DSM
17h 15m2 stops
$845American Airlines
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Wed, Jan 7 - Thu, Apr 30
American Airlines Logo
6:15 pm - 10:20 pmDSM-FLR
21h 05m3 stops
American Airlines Logo
12:30 pm - 11:26 pmFLR-DSM
17h 56m2 stops
$1,083American Airlines
Find Deal
Wed, Jan 7 - Thu, Apr 30

United Airlines flights from Des Moines to Florence

Our best United Airlines deals on Des Moines to Florence flight tickets
United Airlines
Oct 30
DSM1:05 pmDes Moines
19h 15m
2 stops
FLR2:20 pmFlorence Peretola
Nov 6
FLR2:15 pmFlorence Peretola
27h 15m
2 stops
DSM10:30 amDes Moines
$672
Find similar
United Airlines
Oct 31
DSM3:15 pmDes Moines
19h 15m
2 stops
FLR4:30 pmFlorence Peretola
Nov 7
FLR2:15 pmFlorence Peretola
31h 04m
2 stops
DSM2:19 pmDes Moines
$675
Find similar
United Airlines
Nov 14
DSM3:15 pmDes Moines
15h 50m
2 stops
FLR2:05 pmFlorence Peretola
Nov 18
FLR8:00 amFlorence Peretola
22h 44m
2 stops
DSM11:44 pmDes Moines
$678
Find similar

Delta flights from Des Moines to Florence

Our best Delta deals on Des Moines to Florence flight tickets
Delta
Nov 14
DSM5:52 pmDes Moines
13h 33m
2 stops
FLR2:25 pmFlorence Peretola
Nov 18
FLR9:50 amFlorence Peretola
19h 43m
2 stops
DSM10:33 pmDes Moines
$654
Find similar
Delta
Sep 23
DSM2:49 pmDes Moines
16h 36m
2 stops
FLR2:25 pmFlorence Peretola
Oct 2
FLR12:15 pmFlorence Peretola
29h 25m
2 stops
DSM10:40 amDes Moines
$699
Find similar
Delta
Sep 23
DSM3:10 pmDes Moines
21h 25m
2 stops
FLR7:35 pmFlorence Peretola
Sep 30
FLR1:00 pmFlorence Peretola
31h 20m
2 stops
DSM1:20 pmDes Moines
$700
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 10/31

1:05 pm-4:30 pm

2 stops21h 25m

Florence Peretola

Fri 11/7

8:00 am-8:45 pm

2 stops19h 45m

$651

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 11/14

5:52 pm-2:25 pm

2 stops13h 33m

Florence Peretola

Tue 11/18

9:50 am-10:33 pm

2 stops19h 43m

$654

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 10/30

1:05 pm-2:20 pm

2 stops19h 15m

Florence Peretola

Thu 11/6

2:15 pm-12:14 pm

2 stops28h 59m

$672

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 10/31

3:15 pm-4:30 pm

2 stops19h 15m

Florence Peretola

Fri 11/7

2:15 pm-2:19 pm

2 stops31h 04m

$675

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/9

6:20 pm-11:20 am

2 stops35h 00m

Florence Peretola

Sun 3/29

12:25 pm-6:02 pm

2 stops36h 37m

$691

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/9

6:45 pm-4:30 pm

2 stops15h 45m

Florence Peretola

Sun 3/29

5:25 pm-9:36 pm

2 stops35h 11m

$693

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 10/15

1:00 pm-8:15 pm

2 stops24h 15m

Florence Peretola

Sun 10/19

3:40 pm-9:50 pm

2 stops37h 10m

$790

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 3/12

12:53 pm-11:45 am

2 stops16h 52m

Florence Peretola

Sun 3/29

12:25 pm-6:02 pm

2 stops36h 37m

$792

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 1/7

6:15 pm-10:20 pm

3 stops21h 05m

Florence Peretola

Thu 4/30

12:25 pm-10:40 pm

2 stops17h 15m

$845

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 1/7

6:15 pm-10:20 pm

3 stops21h 05m

Florence Peretola

Thu 4/30

12:30 pm-11:26 pm

2 stops17h 56m

$1,083

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Des Moines to Florence

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence?

On average, the least expensive day to fly to Florence from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $1,244. However, this price may fluctuate depending on the airline, the season, and holidays. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Florence on Thursday is $1,991.

What is the cheapest time of day to depart on your flight to Florence?

Our data shows that the cheapest Des Moines to Florence flights are usually those with departure times in the afternoon. Our users have found flights to Florence in the afternoon for as low as $1,238. Flights to Florence are more costly in the morning, with an average ticket price of $1,785. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Des Moines to Florence

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Florence according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Florence (DSM to FLR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florence

Direct flights

None
There are no direct flights from Des Moines to Florence. There are no popular flight routes from Des Moines to Florence.
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  • How far is Des Moines to Florence Peretola by plane?

    The straight-line distance from Des Moines to Florence Peretola is 4923.7 mi. In terms of flight time, this usually takes a little over 13h 33m.

  • When did momondo last update prices for flights from Des Moines Airport to Florence Peretola Airport?

    Prices for flights from Des Moines Airport to Florence Peretola Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Florence Peretola Airport?

  • How old do you have to be to fly from Des Moines Airport to Florence Peretola Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Florence Peretola Airport.

  • What documentation or ID do you need to fly to Florence Peretola Airport?

    The necessary travel and health documents for your Florence Peretola Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Florence?

Best airlines flying from Des Moines to Florence

Compare and see reviews for airlines that fly from Des Moines to Florence with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $790Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
LufthansaPriceFrom $811Free CancellationRating
6.8
7,409 reviews
Search Lufthansa flights
DeltaPriceFrom $955Free CancellationRating
7.9
7,961 reviews
Search Delta flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Siena
Prato
San Gimignano
Montecatini Terme
Pistoia
Arezzo
Colle di Val d'Elsa
Fiesole
Poggibonsi
Impruneta
Greve in Chianti
Monteriggioni
Volterra

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florence with flexible booking policies on momondo?

Flights from Des Moines to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Florence?

Once all potential Des Moines to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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