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Cheap flights from Des Moines to Florence from $491

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florence departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
British Airways Logo
2:16 pm - 10:20 pm
DSM
-
FLR
25h 04m
2 stops
British Airways Logo
7:05 am - 11:49 pm
FLR
-
DSM
23h 44m
2 stops
$491British Airways
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
11:51 am - 9:00 am
DSM
-
FLR
14h 09m
2 stops
Multiple Airlines Logo
6:30 am - 5:02 pm
FLR
-
DSM
17h 32m
2 stops
$500Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
British Airways Logo
2:16 pm - 10:20 pm
DSM
-
FLR
25h 04m
2 stops
British Airways Logo
7:05 am - 11:49 pm
FLR
-
DSM
23h 44m
2 stops
$641British Airways
Wed, Apr 15 - Wed, Apr 22
Lufthansa Logo
11:30 am - 10:00 pm
DSM
-
FLR
27h 30m
2 stops
Lufthansa Logo
6:30 am - 6:08 pm
FLR
-
DSM
17h 38m
2 stops
$689Lufthansa
Tue, Mar 3 - Thu, Mar 12
United Airlines Logo
3:24 pm - 2:00 pm
DSM
-
FLR
15h 36m
2 stops
United Airlines Logo
6:30 am - 10:44 pm
FLR
-
DSM
22h 14m
2 stops
$704United Airlines
Tue, Mar 3 - Thu, Mar 12
Lufthansa Logo
2:04 pm - 10:00 pm
DSM
-
FLR
25h 56m
2 stops
Lufthansa Logo
1:15 pm - 6:08 pm
FLR
-
DSM
34h 53m
2 stops
$710Lufthansa
Tue, Mar 10 - Tue, Mar 17
Iberia Logo
11:09 am - 7:35 pm
DSM
-
FLR
25h 26m
2 stops
Iberia Logo
8:20 pm - 11:49 pm
FLR
-
DSM
34h 29m
2 stops
$713Iberia
Mon, Apr 13 - Sun, Apr 19
Lufthansa Logo
2:04 pm - 10:00 pm
DSM
-
FLR
25h 56m
2 stops
Lufthansa Logo
1:15 pm - 6:08 pm
FLR
-
DSM
34h 53m
2 stops
$717Lufthansa
Tue, Mar 10 - Tue, Mar 17
United Airlines Logo
6:49 pm - 4:30 pm
DSM
-
FLR
39h 41m
2 stops
United Airlines Logo
2:15 pm - 9:41 pm
FLR
-
DSM
37h 26m
2 stops
$798United Airlines
Mon, Mar 16 - Mon, Mar 23
Lufthansa Logo
6:45 pm - 4:35 pm
DSM
-
FLR
14h 50m
2 stops
Lufthansa Logo
1:20 pm - 9:12 pm
FLR
-
DSM
14h 52m
2 stops
$804Lufthansa
Tue, Aug 11 - Sat, Aug 22

Air Canada flights from Des Moines to Florence

Our best Air Canada deals on Des Moines to Florence flight tickets
Air Canada
Aug 11
DSM8:00 amDes Moines
18h 40m
3 stops
FLR9:40 amFlorence Peretola
Aug 22
FLR6:30 amFlorence Peretola
19h 55m
3 stops
DSM7:25 pmDes Moines
$966
Air Canada
Aug 11
DSM8:00 amDes Moines
18h 40m
3 stops
FLR9:40 amFlorence Peretola
Aug 22
FLR6:30 amFlorence Peretola
19h 55m
3 stops
DSM7:25 pmDes Moines
$1,074
Air Canada
Mar 30
DSM1:10 pmDes Moines
17h 50m
3 stops
FLR2:00 pmFlorence Peretola
Apr 6
FLR2:00 pmFlorence Peretola
27h 44m
3 stops
DSM10:44 amDes Moines
$1,221

United Airlines flights from Des Moines to Florence

Our best United Airlines deals on Des Moines to Florence flight tickets
United Airlines
Mar 16
DSM6:49 pmDes Moines
39h 41m
2 stops
FLR4:30 pmFlorence Peretola
Mar 23
FLR2:15 pmFlorence Peretola
37h 26m
2 stops
DSM9:41 pmDes Moines
$798
United Airlines
Mar 4
DSM3:24 pmDes Moines
15h 26m
2 stops
FLR1:50 pmFlorence Peretola
Mar 8
FLR2:15 pmFlorence Peretola
54h 03m
2 stops
DSM2:18 pmDes Moines
$806
United Airlines
Mar 4
DSM11:30 amDes Moines
19h 20m
2 stops
FLR1:50 pmFlorence Peretola
Mar 8
FLR2:15 pmFlorence Peretola
55h 52m
3 stops
DSM4:07 pmDes Moines
$812

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 4/15

2:16 pm-10:20 pm

2 stops25h 04m

Florence Peretola

Wed 4/22

7:05 am-11:49 pm

2 stops23h 44m

$491

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 4/15

11:51 am-9:00 am

2 stops14h 09m

Florence Peretola

Wed 4/22

6:30 am-5:02 pm

2 stops17h 32m

$500

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 4/15

2:16 pm-10:20 pm

2 stops25h 04m

Florence Peretola

Wed 4/22

7:05 am-11:49 pm

2 stops23h 44m

$641

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 3/3

11:30 am-10:00 pm

2 stops27h 30m

Florence Peretola

Thu 3/12

6:30 am-6:08 pm

2 stops17h 38m

$689

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 3/3

3:24 pm-2:00 pm

2 stops15h 36m

Florence Peretola

Thu 3/12

6:30 am-10:44 pm

2 stops22h 14m

$704

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 3/10

2:04 pm-10:00 pm

2 stops25h 56m

Florence Peretola

Tue 3/17

1:15 pm-6:08 pm

2 stops34h 53m

$710

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 4/13

11:09 am-7:35 pm

2 stops25h 26m

Florence Peretola

Sun 4/19

8:20 pm-11:49 pm

2 stops34h 29m

$713

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 3/10

2:04 pm-10:00 pm

2 stops25h 56m

Florence Peretola

Tue 3/17

1:15 pm-6:08 pm

2 stops34h 53m

$717

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/16

6:49 pm-4:30 pm

2 stops39h 41m

Florence Peretola

Mon 3/23

2:15 pm-9:41 pm

2 stops37h 26m

$798

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 8/11

6:45 pm-4:35 pm

2 stops14h 50m

Florence Peretola

Sat 8/22

1:20 pm-9:12 pm

2 stops14h 52m

$804

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Des Moines to Florence

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Florence Peretola?

British Airways and Air Canada are the most popular carriers operating from Des Moines to Florence Peretola

When to book flights from Des Moines to Florence

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Florence according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Florence (DSM to FLR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florence

Fastest flight time

14h 09m

Direct flights

None
The fastest flight from Des Moines to Florence takes 14h 09m
There are no direct flights from Des Moines to Florence. There are no popular flight routes from Des Moines to Florence.
Search flight deals

  • How far is Des Moines to Florence Peretola by plane?

    The straight-line distance from Des Moines to Florence Peretola is 4923.7 mi. In terms of flight time, this usually takes a little over 14h 09m.

  • When did momondo last update prices for flights from Des Moines Airport to Florence Peretola Airport?

    Prices for flights from Des Moines Airport to Florence Peretola Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Florence Peretola Airport?

  • How old do you have to be to fly from Des Moines Airport to Florence Peretola Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Florence Peretola Airport.

  • What documentation or ID do you need to fly to Florence Peretola Airport?

    The necessary travel and health documents for your Florence Peretola Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Florence?

Best airlines flying from Des Moines to Florence

Compare and see reviews for airlines that fly from Des Moines to Florence with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $502Free CancellationRating
7.4
9,296 reviews
Search United Airlines flights
DeltaPriceFrom $505Free CancellationRating
7.9
8,205 reviews
Search Delta flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Siena
Prato
San Gimignano
Montecatini Terme
Arezzo
Colle di Val d'Elsa
Fiesole
Pistoia
Impruneta
Greve in Chianti
Monteriggioni
Volterra
Poggibonsi

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florence with flexible booking policies on momondo?

Flights from Des Moines to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Florence?

Once all potential Des Moines to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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