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Cheap flights from Des Moines to Florence from $484

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florence departing on 8/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:55 pm - 4:35 pm
DSM
-
FLR
14h 40m
2 stops
Lufthansa Logo
10:25 am - 11:35 pm
FLR
-
DSM
20h 10m
2 stops
$956Lufthansa
Wed, Oct 7 - Tue, Oct 13
Lufthansa Logo
11:23 am - 6:30 pm
DSM
-
FLR
24h 07m
2 stops
Lufthansa Logo
9:50 am - 10:51 pm
FLR
-
DSM
20h 01m
2 stops
$1,008Lufthansa
Wed, Jul 1 - Wed, Jul 8
KLM Logo
6:03 pm - 7:00 pm
DSM
-
FLR
41h 57m
2 stops
KLM Logo
6:30 am - 5:12 pm
FLR
-
DSM
17h 42m
2 stops
$1,048KLM
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
6:50 pm - 10:30 pm
DSM
-
FLR
20h 40m
2 stops
Lufthansa Logo
9:50 am - 10:35 pm
FLR
-
DSM
19h 45m
2 stops
$1,052Lufthansa
Wed, Jul 1 - Wed, Jul 15
Delta Logo
5:34 pm - 7:40 pm
DSM
-
FLR
19h 06m
2 stops
Delta Logo
6:30 am - 8:49 pm
FLR
-
DSM
21h 19m
2 stops
$1,058Delta
Thu, Jul 2 - Thu, Jul 9
Lufthansa Logo
3:01 pm - 10:30 pm
DSM
-
FLR
24h 29m
2 stops
Lufthansa Logo
1:20 pm - 10:51 pm
FLR
-
DSM
16h 31m
2 stops
$1,059Lufthansa
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
11:23 am - 6:30 pm
DSM
-
FLR
24h 07m
2 stops
Lufthansa Logo
9:50 am - 10:51 pm
FLR
-
DSM
20h 01m
2 stops
$1,084Lufthansa
Wed, Jul 1 - Wed, Jul 8
Lufthansa Logo
11:23 am - 6:30 pm
DSM
-
FLR
24h 07m
2 stops
Lufthansa Logo
9:50 am - 10:51 pm
FLR
-
DSM
20h 01m
2 stops
$1,091Lufthansa
Wed, Jul 1 - Wed, Jul 8
Multiple Airlines Logo
6:50 pm - 6:30 pm
DSM
-
FLR
16h 40m
2 stops
Multiple Airlines Logo
8:15 am - 10:51 pm
FLR
-
DSM
21h 36m
3 stops
$1,096Multiple Airlines
Wed, Jul 1 - Wed, Jul 8
KLM Logo
5:00 pm - 4:50 pm
DSM
-
FLR
16h 50m
2 stops
KLM Logo
6:30 am - 5:12 pm
FLR
-
DSM
17h 42m
2 stops
$1,097KLM
Wed, Jul 1 - Wed, Jul 8

Lufthansa flights from Des Moines to Florence

Our best Lufthansa deals on Des Moines to Florence flight tickets
Lufthansa
Oct 7
DSM6:55 pmDes Moines
14h 40m
2 stops
FLR4:35 pmFlorence Peretola
Oct 13
FLR10:25 amFlorence Peretola
20h 10m
2 stops
DSM11:35 pmDes Moines
$956
Lufthansa
Jul 1
DSM11:23 amDes Moines
24h 07m
2 stops
FLR6:30 pmFlorence Peretola
Jul 8
FLR9:50 amFlorence Peretola
20h 01m
2 stops
DSM10:51 pmDes Moines
$1,008
Lufthansa
Jul 1
DSM6:50 pmDes Moines
20h 40m
2 stops
FLR10:30 pmFlorence Peretola
Jul 15
FLR9:50 amFlorence Peretola
19h 45m
2 stops
DSM10:35 pmDes Moines
$1,052

Air Canada flights from Des Moines to Florence

Our best Air Canada deals on Des Moines to Florence flight tickets
Air Canada
Jun 30
DSM11:23 amDes Moines
18h 27m
3 stops
FLR12:50 pmFlorence Peretola
Jul 7
FLR6:30 amFlorence Peretola
19h 55m
3 stops
DSM7:25 pmDes Moines
$1,376
Air Canada
Jun 30
DSM11:23 amDes Moines
18h 27m
3 stops
FLR12:50 pmFlorence Peretola
Jul 7
FLR6:30 amFlorence Peretola
18h 42m
3 stops
DSM6:12 pmDes Moines
$1,380
Air Canada
Jun 27
DSM6:00 amDes Moines
22h 30m
3 stops
FLR11:30 amFlorence Peretola
Jul 4
FLR8:15 amFlorence Peretola
16h 58m
2 stops
DSM6:13 pmDes Moines
$1,418

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 10/7

6:55 pm-4:35 pm

2 stops14h 40m

Florence Peretola

Tue 10/13

10:25 am-11:35 pm

2 stops20h 10m

$956

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

11:23 am-6:30 pm

2 stops24h 07m

Florence Peretola

Wed 7/8

9:50 am-10:51 pm

2 stops20h 01m

$1,008

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

6:03 pm-7:00 pm

2 stops41h 57m

Florence Peretola

Wed 7/8

6:30 am-5:12 pm

2 stops17h 42m

$1,048

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

6:50 pm-10:30 pm

2 stops20h 40m

Florence Peretola

Wed 7/15

9:50 am-10:35 pm

2 stops19h 45m

$1,052

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 7/2

5:34 pm-7:40 pm

2 stops19h 06m

Florence Peretola

Thu 7/9

6:30 am-8:49 pm

2 stops21h 19m

$1,058

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

3:01 pm-10:30 pm

2 stops24h 29m

Florence Peretola

Wed 7/8

1:20 pm-10:51 pm

2 stops16h 31m

$1,059

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

11:23 am-6:30 pm

2 stops24h 07m

Florence Peretola

Wed 7/8

9:50 am-10:51 pm

2 stops20h 01m

$1,084

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

11:23 am-6:30 pm

2 stops24h 07m

Florence Peretola

Wed 7/8

9:50 am-10:51 pm

2 stops20h 01m

$1,091

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

6:50 pm-6:30 pm

2 stops16h 40m

Florence Peretola

Wed 7/8

8:15 am-10:51 pm

3 stops21h 36m

$1,096
Quickest round-trip

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 7/1

5:00 pm-4:50 pm

2 stops16h 50m

Florence Peretola

Wed 7/8

6:30 am-5:12 pm

2 stops17h 42m

$1,097

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Des Moines to Florence

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florence?

If you aren’t able to travel during the month of November, then book flights to Florence from Des Moines during February instead. Flights to Florence in February, while not as cheap as those in November, still average around $502.

When to book flights from Des Moines to Florence

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Florence according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Florence (DSM to FLR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florence

Fastest flight time

14h 40m

Direct flights

None
The fastest flight from Des Moines to Florence takes 14h 40m
There are no direct flights from Des Moines to Florence. There are no popular flight routes from Des Moines to Florence.
Search flight deals

Frequently asked questions about flying from Des Moines to Florence

  • How far is Des Moines to Florence Peretola by plane?

    The straight-line distance from Des Moines to Florence Peretola is 4923.7 mi. In terms of flight time, this usually takes a little over 14h 40m.

  • When did momondo last update prices for flights from Des Moines Airport to Florence Peretola Airport?

    Prices for flights from Des Moines Airport to Florence Peretola Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Florence Peretola Airport?

  • How old do you have to be to fly from Des Moines Airport to Florence Peretola Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Florence Peretola Airport.

  • What documentation or ID do you need to fly to Florence Peretola Airport?

    The necessary travel and health documents for your Florence Peretola Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Florence?

Best airlines flying from Des Moines to Florence

Compare and see reviews for airlines that fly from Des Moines to Florence with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $502Free CancellationRating
7.4
9,737 reviews
Search United Airlines flights
DeltaPriceFrom $701Free CancellationRating
7.9
8,447 reviews
Search Delta flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Prato
Siena
San Gimignano
Montecatini Terme
Pistoia
Fiesole
Arezzo
Colle di Val d'Elsa
Monteriggioni
Greve in Chianti
Impruneta
Volterra
Poggibonsi

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florence with flexible booking policies on momondo?

Flights from Des Moines to Florence with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Florence?

Once all potential Des Moines to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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