Cheap flights from Colorado to Panama from $284

The month of March is, on average, the cheapest month to fly to Panama from Colorado, with most prices found around $234. If you don’t want to visit Panama in March, then you should wait until May to fly from Colorado, when ticket prices are also cheap, with an average price of $308.

According to our data, Tuesday is the cheapest day to fly to Panama from Colorado. The lowest ticket price found for a Tuesday departure recently was $534. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Colorado to Panama for around $618.

Fly from Denver Intl to Panama City Tocumen Intl for the best Colorado - Panama flight prices

You are more likely to see cheaper flights to Panama from Colorado when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $655 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Colorado for as low as $535 on momondo.

There are 3 cabin classes available to choose from on Colorado to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 3% on your flight if you consider stops on a Colorado to Panama flight.

As of June 2026, there are 2 flights per day flying from Colorado to Panama. The most common time of day flights depart is 10:00PM, with 100% of flights taking off in the evening.

As of June 2026, 14 flights take off from Colorado and land in Panama each week. The most common flight departure day for this route is Wed, with 29% of weekly flights taking off on this day.