Cheap flights from Colorado to Panama from $267

The month of April is, on average, the cheapest month to fly to Panama from Colorado, with most prices found around $596. If you don’t want to visit Panama in April, then you should wait until May to fly from Colorado, when ticket prices are also cheap, with an average price of $607.

According to our data, Tuesday is the cheapest day to fly to Panama from Colorado. The lowest ticket price found for a Tuesday departure recently was $538. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Colorado to Panama for around $627.

Fly from Denver Intl to Panama City Tocumen Intl for the best Colorado - Panama flight prices

You are more likely to see cheaper flights to Panama from Colorado when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $667 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Colorado for as low as $572 on momondo.

There are 3 cabin classes available to choose from on Colorado to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 62% on your flight if you consider stops on a Colorado to Panama flight.

American Airlines and Copa Airlines are the most popular carriers operating from Colorado to Panama

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama from Colorado according to our data. Copa Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

As of August 2026, there are 1 flights per day flying from Colorado to Panama. The most common time of day flights depart is 10:00PM, with 100% of flights taking off in the evening.

As of August 2026, 12 flights take off from Colorado and land in Panama each week. The most common flight departure day for this route is Mon, with 17% of weekly flights taking off on this day.