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Cheap flights from Chicago to Panama City from $107

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Panama City departing on 11/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Avianca Logo
10:20 pm - 2:00 pmORD-PTY
14h 40m1 stop
Avianca Logo
2:55 am - 8:20 pmPTY-ORD
18h 25m1 stop
$269Avianca
Find Deal
Thu, Feb 12 - Sun, Feb 15
Avianca Logo
2:35 pm - 12:10 amORD-PTY
9h 35m1 stop
Avianca Logo
9:45 am - 9:20 pmPTY-ORD
11h 35m1 stop
$272Avianca
Find Deal
Thu, Oct 23 - Wed, Oct 29
Avianca Logo
10:20 pm - 8:50 amORD-PTY
9h 30m1 stop
Avianca Logo
2:55 am - 8:20 pmPTY-ORD
18h 25m1 stop
$275Avianca
Find Deal
Thu, Feb 5 - Mon, Feb 9
Copa Airlines Logo
3:07 pm - 8:35 pmORD-PTY
5h 28mnonstop
Copa Airlines Logo
7:20 pm - 12:05 amPTY-ORD
5h 45mnonstop
$448Copa Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Copa Airlines Logo
7:59 am - 1:21 pmORD-PTY
5h 22mnonstop
Copa Airlines Logo
7:55 am - 1:41 pmPTY-ORD
5h 46mnonstop
$451Copa Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
United Airlines Logo
6:00 am - 6:37 pmORD-PTY
12h 37m1 stop
United Airlines Logo
3:30 pm - 12:14 amPTY-ORD
8h 44m1 stop
$456United Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 12
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
3:46 pm - 11:32 pmPTY-MDW
8h 46m1 stop
$465Delta
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Sat, Nov 29 - Wed, Dec 3
American Airlines Logo
12:19 am - 1:43 pmORD-PTY
12h 24m1 stop
American Airlines Logo
4:37 pm - 12:37 amPTY-ORD
9h 00m1 stop
$465American Airlines
Find Deal
Sun, Nov 30 - Mon, Dec 8
Delta Logo
9:30 am - 8:04 pmMDW-PTY
9h 34m2 stops
Delta Logo
8:05 am - 4:25 pmPTY-MDW
9h 20m1 stop
$470Delta
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Sat, Jan 10 - Sat, Jan 17
American Airlines Logo
9:07 pm - 1:43 pmORD-PTY
15h 36m2 stops
American Airlines Logo
2:50 pm - 12:37 amPTY-ORD
10h 47m1 stop
$470American Airlines
Find Deal
Mon, Dec 1 - Mon, Dec 8

Avianca flights from Chicago to Panama City

Our best Avianca deals on Chicago to Panama City flight tickets
Avianca
Feb 12
ORD10:20 pmChicago O'Hare Intl
14h 40m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Feb 15
PTY2:55 amPanama City Tocumen Intl
18h 25m
1 stop
ORD8:20 pmChicago O'Hare Intl
$269
Find similar
Avianca
Oct 23
ORD2:35 pmChicago O'Hare Intl
9h 35m
1 stop
PTY12:10 amPanama City Tocumen Intl
Oct 29
PTY9:45 amPanama City Tocumen Intl
11h 35m
1 stop
ORD9:20 pmChicago O'Hare Intl
$272
Find similar
Avianca
Feb 5
ORD10:20 pmChicago O'Hare Intl
9h 30m
1 stop
PTY8:50 amPanama City Tocumen Intl
Feb 9
PTY2:55 amPanama City Tocumen Intl
18h 25m
1 stop
ORD8:20 pmChicago O'Hare Intl
$275
Find similar

Copa Airlines flights from Chicago to Panama City

Our best Copa Airlines deals on Chicago to Panama City flight tickets
Copa Airlines
Oct 31
ORD3:07 pmChicago O'Hare Intl
5h 28m
PTY8:35 pmPanama City Tocumen Intl
Nov 7
PTY7:20 pmPanama City Tocumen Intl
5h 45m
ORD12:05 amChicago O'Hare Intl
$448
Find similar
Copa Airlines
Sep 23
ORD8:02 amChicago O'Hare Intl
5h 20m
PTY1:22 pmPanama City Tocumen Intl
Sep 25
PTY6:45 pmPanama City Tocumen Intl
5h 36m
ORD12:21 amChicago O'Hare Intl
$450
Find similar
Copa Airlines
Sep 24
ORD8:02 amChicago O'Hare Intl
5h 20m
PTY1:22 pmPanama City Tocumen Intl
Oct 1
PTY7:55 amPanama City Tocumen Intl
5h 46m
ORD1:41 pmChicago O'Hare Intl
$451
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Chicago to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 2/12

10:20 pm-2:00 pm

1 stop14h 40m

Panama City Tocumen Intl

Sun 2/15

2:55 am-8:20 pm

1 stop18h 25m

$269

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/23

2:35 pm-12:10 am

1 stop9h 35m

Panama City Tocumen Intl

Wed 10/29

9:45 am-9:20 pm

1 stop11h 35m

$272

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 2/5

10:20 pm-8:50 am

1 stop9h 30m

Panama City Tocumen Intl

Mon 2/9

2:55 am-8:20 pm

1 stop18h 25m

$275

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 10/31

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Fri 11/7

7:20 pm-12:05 am

Nonstop5h 45m

$448

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/23

7:59 am-1:21 pm

Nonstop5h 22m

Panama City Tocumen Intl

Mon 10/27

7:55 am-1:41 pm

Nonstop5h 46m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/2

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sun 10/12

3:30 pm-12:14 am

1 stop8h 44m

$456

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 11/29

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Wed 12/3

3:46 pm-11:32 pm

1 stop8h 46m

$465

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sun 11/30

12:19 am-1:43 pm

1 stop12h 24m

Panama City Tocumen Intl

Mon 12/8

4:37 pm-12:37 am

1 stop9h 00m

$465

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 1/10

9:30 am-8:04 pm

2 stops9h 34m

Panama City Tocumen Intl

Sat 1/17

8:05 am-4:25 pm

1 stop9h 20m

$470

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Mon 12/1

9:07 pm-1:43 pm

2 stops15h 36m

Panama City Tocumen Intl

Mon 12/8

2:50 pm-12:37 am

1 stop10h 47m

$470

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Chicago to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Chicago to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $464. If you’re not able to fly to Panama City in November, then July is your next best option. Flight prices from Chicago to Panama City during July average around $523.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $538. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $608. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Chicago to Panama City during this time can be as low as $510. Try not to purchase tickets at noon because they tend to be around $609. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago to Panama City Tocumen Intl flight route?

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Chicago - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $584 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Chicago for as low as $503 on momondo.

What cabin class options are available on Chicago to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Chicago to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Panama City flights?

You could potentially save up to 64% on your flight if you consider stops on a Chicago to Panama City flight.

How have Chicago to Panama City flight prices changed over time?

When to book flights from Chicago to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Panama City (CHI to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Panama City

Best Price Found

$165

Fastest flight time

5h 13m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Chicago in the past 72 hours is $165. The best round-trip flight deal from Chicago to Panama City found on momondo in the last 72 hours is $404.
The fastest flight from Chicago to Panama City takes 5h 13m
Direct flights go from Chicago to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Chicago to Panama City Tocumen Intl by plane?

    The straight-line distance from Chicago to Panama City Tocumen Intl is 2323.9 mi. Typically, this will take 5h 22m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago to Panama City Tocumen Intl Airport?

    Prices for flights from Chicago to Panama City Tocumen Intl Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Chicago to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago to Panama City?

  • What is the most popular airline from Chicago to Panama City?

Best airlines flying from Chicago to Panama City

Compare and see reviews for airlines that fly from Chicago to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $334Free CancellationRating
6.7
2,436 reviews
Search Avianca flights
Copa AirlinesPriceFrom $464Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $478Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
DeltaPriceFrom $479Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $563Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

  • Copa Airlines Flights From Chicago to Panama City

    Copa Airlines flies from Chicago to Panama City around 10 times per week, with 1,533 momondo users rating the airline 7.6/10. The cheapest Copa Airlines deal from Chicago to Panama City in the last 72 hours was $464 (round-trip), much lower than the average airfare cost of $583 for Copa Airlines flights on this route.

  • United Airlines Flights From Chicago to Panama City

    United Airlines (7.4/10 from 8,926 reviews) operates around 10 flights from Chicago to Panama City in any given week. The average United Airlines airfare for this route is around $653, with deals from around $478 rare but found on momondo. Referenced prices are for round-trip Chicago to Panama City flight searches in the last 72 hours.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Panama City with flexible booking policies on momondo?

Yes. All flights to Panama City from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Panama City.

I’m not ready to book a flight from Chicago to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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