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Cheap flights from Chicago to Panama City from $175

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Panama City departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago to Panama City

Cheap round-trip flights

Logo
10:27 am - 7:29 pmORD-PTY
9h 02m1 stop
Logo
9:33 pm - 9:22 amPTY-ORD
11h 49m1 stop
$451
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Wed, Oct 8 - Wed, Oct 22
Logo
10:27 am - 7:29 pmORD-PTY
9h 02m1 stop
Logo
9:33 pm - 9:22 amPTY-ORD
11h 49m1 stop
$452
Find Deal
Fri, Oct 17 - Thu, Oct 23
Logo
11:52 am - 8:19 pmORD-PTY
8h 27m1 stop
Logo
12:03 pm - 1:03 amPTY-ORD
13h 00m1 stop
$453
Find Deal
Thu, Oct 23 - Sun, Oct 26
Avianca Logo
2:35 pm - 12:45 amORD-PTY
10h 10m1 stop
Avianca Logo
10:05 pm - 1:15 pmPTY-ORD
15h 10m1 stop
$468Avianca
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Wed, Oct 15 - Tue, Oct 21
Avianca Logo
11:20 pm - 4:55 pmORD-PTY
17h 35m1 stop
Avianca Logo
9:45 am - 8:20 pmPTY-ORD
11h 35m1 stop
$477Avianca
Find Deal
Tue, Oct 28 - Sat, Nov 8
Avianca Logo
2:35 pm - 12:10 amORD-PTY
9h 35m1 stop
Avianca Logo
9:45 am - 9:20 pmPTY-ORD
11h 35m1 stop
$478Avianca
Find Deal
Thu, Oct 23 - Mon, Oct 27
Avianca Logo
2:35 pm - 12:10 amORD-PTY
9h 35m1 stop
Avianca Logo
3:20 am - 1:15 pmPTY-ORD
9h 55m1 stop
$481Avianca
Find Deal
Thu, Oct 16 - Tue, Oct 21
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
8:05 am - 3:30 pmPTY-MDW
8h 25m1 stop
$587Delta
Find Deal
Tue, Nov 25 - Sat, Dec 6
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
3:17 pm - 8:45 amPTY-MDW
18h 28m2 stops
$592Delta
Find Deal
Tue, Nov 25 - Thu, Dec 4
Delta Logo
6:00 am - 7:59 pmMDW-PTY
12h 59m1 stop
Delta Logo
3:37 pm - 11:32 pmPTY-MDW
8h 55m1 stop
$596Delta
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Sat, Nov 22 - Thu, Nov 27

Avianca flights from Chicago to Panama City

Our best Avianca deals on Chicago to Panama City flight tickets
Avianca
Oct 15
ORD2:35 pmChicago O'Hare Intl
10h 10m
1 stop
PTY12:45 amPanama City Tocumen Intl
Oct 21
PTY10:05 pmPanama City Tocumen Intl
15h 10m
1 stop
ORD1:15 pmChicago O'Hare Intl
$468
Find similar
Avianca
Oct 28
ORD11:20 pmChicago O'Hare Intl
17h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
Nov 8
PTY9:45 amPanama City Tocumen Intl
11h 35m
1 stop
ORD8:20 pmChicago O'Hare Intl
$477
Find similar
Avianca
Oct 23
ORD2:35 pmChicago O'Hare Intl
9h 35m
1 stop
PTY12:10 amPanama City Tocumen Intl
Oct 27
PTY9:45 amPanama City Tocumen Intl
11h 35m
1 stop
ORD9:20 pmChicago O'Hare Intl
$478
Find similar

Delta flights from Chicago to Panama City

Our best Delta deals on Chicago to Panama City flight tickets
Delta
Nov 25
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Dec 6
PTY8:05 amPanama City Tocumen Intl
8h 25m
1 stop
MDW3:30 pmChicago Midway
$587
Find similar
Delta
Nov 25
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Dec 4
PTY3:17 pmPanama City Tocumen Intl
18h 28m
2 stops
MDW8:45 amChicago Midway
$592
Find similar
Delta
Nov 22
MDW6:00 amChicago Midway
12h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Nov 27
PTY3:37 pmPanama City Tocumen Intl
8h 55m
1 stop
MDW11:32 pmChicago Midway
$596
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Chicago to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 10/8

10:27 am-7:29 pm

1 stop9h 02m

Panama City Tocumen Intl

Wed 10/22

9:33 pm-9:22 am

1 stop11h 49m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 10/17

10:27 am-7:29 pm

1 stop9h 02m

Panama City Tocumen Intl

Thu 10/23

9:33 pm-9:22 am

1 stop11h 49m

$452

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/23

11:52 am-8:19 pm

1 stop8h 27m

Panama City Tocumen Intl

Sun 10/26

12:03 pm-1:03 am

1 stop13h 00m

$453

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 10/15

2:35 pm-12:45 am

1 stop10h 10m

Panama City Tocumen Intl

Tue 10/21

10:05 pm-1:15 pm

1 stop15h 10m

$468

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Tue 10/28

11:20 pm-4:55 pm

1 stop17h 35m

Panama City Tocumen Intl

Sat 11/8

9:45 am-8:20 pm

1 stop11h 35m

$477

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/23

2:35 pm-12:10 am

1 stop9h 35m

Panama City Tocumen Intl

Mon 10/27

9:45 am-9:20 pm

1 stop11h 35m

$478

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/16

2:35 pm-12:10 am

1 stop9h 35m

Panama City Tocumen Intl

Tue 10/21

3:20 am-1:15 pm

1 stop9h 55m

$481

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 11/25

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Sat 12/6

8:05 am-3:30 pm

1 stop8h 25m

$587

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 11/25

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Thu 12/4

3:17 pm-8:45 am

2 stops18h 28m

$592

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 11/22

6:00 am-7:59 pm

1 stop12h 59m

Panama City Tocumen Intl

Thu 11/27

3:37 pm-11:32 pm

1 stop8h 55m

$596

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Chicago to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Panama City?

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Chicago to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $464. If you’re not able to fly to Panama City in November, then September is your next best option. Flight prices from Chicago to Panama City during September average around $479.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $540. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $614. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Chicago to Panama City during this time can be as low as $510. Try not to purchase tickets at noon because they tend to be around $610. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago to Panama City Tocumen Intl flight route?

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Chicago - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $570 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Chicago for as low as $509 on momondo.

What cabin class options are available on Chicago to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Chicago to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Panama City flights?

You could potentially save up to 64% on your flight if you consider stops on a Chicago to Panama City flight.

How have Chicago to Panama City flight prices changed over time?

When to book flights from Chicago to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Panama City (CHI to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Panama City

Best Price Found

$192

Fastest flight time

5h 20m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Chicago in the past 72 hours is $192. The best round-trip flight deal from Chicago to Panama City found on momondo in the last 72 hours is $449.
The fastest flight from Chicago to Panama City takes 5h 20m
Direct flights go from Chicago to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Chicago to Panama City Tocumen Intl by plane?

    The straight-line distance from Chicago to Panama City Tocumen Intl is 2323.9 mi. Typically, this will take 6h 52m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago to Panama City Tocumen Intl Airport?

    Prices for flights from Chicago to Panama City Tocumen Intl Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Chicago to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago to Panama City?

  • What is the most popular airline from Chicago to Panama City?

Best airlines flying from Chicago to Panama City

Compare and see reviews for airlines that fly from Chicago to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $339Free CancellationRating
6.7
2,420 reviews
Search Avianca flights
Copa AirlinesPriceFrom $464Free CancellationRating
7.5
1,517 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $478Free CancellationRating
7.4
8,944 reviews
Search United Airlines flights
DeltaPriceFrom $479Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $563Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

  • Copa Airlines Flights From Chicago to Panama City

    Copa Airlines flies from Chicago to Panama City around 11 times per week, with 1,517 momondo users rating the airline 7.5/10. The cheapest Copa Airlines deal from Chicago to Panama City in the last 72 hours was $464 (round-trip), much lower than the average airfare cost of $589 for Copa Airlines flights on this route.

  • United Airlines Flights From Chicago to Panama City

    United Airlines (7.4/10 from 8,944 reviews) operates around 11 flights from Chicago to Panama City in any given week. The average United Airlines airfare for this route is around $651, with deals from around $478 rare but found on momondo. Referenced prices are for round-trip Chicago to Panama City flight searches in the last 72 hours.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Panama City with flexible booking policies on momondo?

Yes. All flights to Panama City from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Panama City.

I’m not ready to book a flight from Chicago to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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