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Cheap flights from Charleston to Panama from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama departing on 4/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 3:01 pm
CHS
-
PTY
10h 01m
1 stop
American Airlines Logo
1:50 pm - 11:59 pm
PTY
-
CHS
9h 09m
1 stop
$421American Airlines
Tue, Mar 31 - Fri, Apr 3
American Airlines Logo
7:43 pm - 12:40 pm
CHS
-
PTY
17h 57m
2 stops
American Airlines Logo
3:51 pm - 11:59 pm
PTY
-
CHS
7h 08m
1 stop
$425American Airlines
Tue, Mar 31 - Fri, Apr 3
United Airlines Logo
7:40 pm - 4:04 am
CHS
-
PTY
9h 24m
1 stop
United Airlines Logo
7:55 am - 9:59 pm
PTY
-
CHS
13h 04m
1 stop
$427United Airlines
Mon, Apr 13 - Mon, Apr 20
American Airlines Logo
8:08 pm - 3:01 pm
CHS
-
PTY
19h 53m
1 stop
American Airlines Logo
1:50 pm - 11:59 pm
PTY
-
CHS
9h 09m
1 stop
$429American Airlines
Mon, Mar 30 - Fri, Apr 3
American Airlines Logo
7:43 pm - 12:40 pm
CHS
-
PTY
17h 57m
2 stops
American Airlines Logo
1:50 pm - 2:14 pm
PTY
-
CHS
23h 24m
2 stops
$440American Airlines
Tue, Mar 31 - Fri, Apr 3
American Airlines Logo
8:21 pm - 12:46 pm
CHS
-
PTY
17h 25m
2 stops
American Airlines Logo
1:49 pm - 11:12 am
PTY
-
CHS
20h 23m
2 stops
$445American Airlines
Mon, Apr 13 - Mon, Apr 20
American Airlines Logo
8:09 pm - 12:46 pm
CHS
-
PTY
17h 37m
1 stop
American Airlines Logo
1:49 pm - 11:49 am
PTY
-
CHS
21h 00m
2 stops
$449American Airlines
Mon, Apr 20 - Fri, Apr 24
United Airlines Logo
5:15 pm - 2:14 pm
CHS
-
PTY
21h 59m
1 stop
United Airlines Logo
10:55 pm - 9:00 am
PTY
-
CHS
9h 05m
1 stop
$450United Airlines
Mon, Apr 20 - Fri, Apr 24
American Airlines Logo
6:00 am - 12:40 pm
CHS
-
PTY
7h 40m
1 stop
American Airlines Logo
1:40 pm - 11:59 pm
PTY
-
CHS
9h 19m
1 stop
$453American Airlines
Tue, Mar 17 - Thu, Mar 26
American Airlines Logo
6:10 am - 2:20 pm
CHS
-
PTY
9h 10m
2 stops
American Airlines Logo
3:10 pm - 11:59 pm
PTY
-
CHS
7h 49m
1 stop
$457American Airlines
Tue, Mar 17 - Thu, Mar 26

United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets
United Airlines
Apr 13
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 20
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$427
United Airlines
Apr 20
CHS5:15 pmCharleston
21h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Apr 24
PTY10:55 pmPanama City Tocumen Intl
9h 05m
1 stop
CHS9:00 amCharleston
$450
United Airlines
Jun 6
CHS6:50 amCharleston
8h 24m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Jun 14
PTY10:00 amPanama City Tocumen Intl
11h 15m
1 stop
CHS10:15 pmCharleston
$461

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets
American Airlines
Mar 31
CHS6:00 amCharleston
10h 01m
1 stop
PTY3:01 pmPanama City Tocumen Intl
Apr 3
PTY1:50 pmPanama City Tocumen Intl
9h 09m
1 stop
CHS11:59 pmCharleston
$421
American Airlines
Mar 31
CHS7:43 pmCharleston
17h 57m
2 stops
PTY12:40 pmPanama City Tocumen Intl
Apr 3
PTY3:51 pmPanama City Tocumen Intl
7h 08m
1 stop
CHS11:59 pmCharleston
$425
American Airlines
Mar 30
CHS8:08 pmCharleston
19h 53m
1 stop
PTY3:01 pmPanama City Tocumen Intl
Apr 3
PTY1:50 pmPanama City Tocumen Intl
9h 09m
1 stop
CHS11:59 pmCharleston
$429

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/31

6:00 am-3:01 pm

1 stop10h 01m

Panama City Tocumen Intl

Fri 4/3

1:50 pm-11:59 pm

1 stop9h 09m

$421

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/31

7:43 pm-12:40 pm

2 stops17h 57m

Panama City Tocumen Intl

Fri 4/3

3:51 pm-11:59 pm

1 stop7h 08m

$425

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 4/13

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Mon 4/20

7:55 am-9:59 pm

1 stop13h 04m

$427

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 3/30

8:08 pm-3:01 pm

1 stop19h 53m

Panama City Tocumen Intl

Fri 4/3

1:50 pm-11:59 pm

1 stop9h 09m

$429

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/31

7:43 pm-12:40 pm

2 stops17h 57m

Panama City Tocumen Intl

Fri 4/3

1:50 pm-2:14 pm

2 stops23h 24m

$440

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 4/13

8:21 pm-12:46 pm

2 stops17h 25m

Panama City Tocumen Intl

Mon 4/20

1:49 pm-11:12 am

2 stops20h 23m

$445

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 4/20

8:09 pm-12:46 pm

1 stop17h 37m

Panama City Tocumen Intl

Fri 4/24

1:49 pm-11:49 am

2 stops21h 00m

$449

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 4/20

5:15 pm-2:14 pm

1 stop21h 59m

Panama City Tocumen Intl

Fri 4/24

10:55 pm-9:00 am

1 stop9h 05m

$450

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/17

6:00 am-12:40 pm

1 stop7h 40m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-11:59 pm

1 stop9h 19m

$453

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/17

6:10 am-2:20 pm

2 stops9h 10m

Panama City Tocumen Intl

Thu 3/26

3:10 pm-11:59 pm

1 stop7h 49m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $389. If you don’t want to visit Panama in September, then you should wait until August to fly from Charleston, when ticket prices are also cheap, with an average price of $456.

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Fastest flight time

8h 10m

Direct flights

None
The fastest flight from Charleston to Panama takes 8h 10m
There are no direct flights from Charleston to Panama. There are no popular flight routes from Charleston to Panama.
Search flight deals

  • When did momondo last update prices for flights from Charleston Airport to Panama?

    Prices for flights from Charleston Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Charleston Airport to Panama?

  • How old do you have to be to fly from Charleston Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $309Free CancellationRating
7.9
8,244 reviews
Search Delta flights
American AirlinesPriceFrom $363Free CancellationRating
7.1
11,370 reviews
Search American Airlines flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,370 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

It is quick and easy to find Charleston to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Panama?

Once you have performed a search for Charleston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

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