What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Charleston according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to Panama?

Prices for flights from Charleston Airport to Panama are updated daily.

How many operators does momondo search for flights from Charleston Airport to Panama?

As of September 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.

How old do you have to be to fly from Charleston Airport to Panama?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.

What documentation or ID do you need to fly to Panama?

The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$374 Cheap Flights from Charleston to Panama in 2025/26

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Round-trip

Cheap round-trip flights

5:39 pm - 1:49 pmCHS-PTY

20h 10m2 stops

2:49 pm - 8:29 amPTY-CHS

17h 40m2 stops

$374American Airlines

Find Deal

Mon, Nov 3 - Fri, Nov 7

7:57 pm - 1:49 pmCHS-PTY

17h 52m1 stop

2:49 pm - 11:59 pmPTY-CHS

9h 10m1 stop

$377American Airlines

Find Deal

Mon, Nov 3 - Fri, Nov 7

7:41 pm - 2:03 pmCHS-PTY

19h 22m2 stops

3:15 pm - 8:16 amPTY-CHS

16h 01m2 stops

$382American Airlines

Find Deal

Wed, Oct 15 - Wed, Oct 22

6:30 am - 2:45 pmCHS-PTY

8h 15m1 stop

8:55 am - 9:59 pmPTY-CHS

13h 04m1 stop

$389United Airlines

Find Deal

Mon, Nov 24 - Sun, Nov 30

6:31 pm - 12:10 pmCHS-PTY

18h 39m2 stops

1:50 pm - 10:59 amPTY-CHS

20h 09m2 stops

$394American Airlines

Find Deal

Sat, Mar 14 - Tue, Mar 17

7:44 pm - 2:03 pmCHS-PTY

19h 19m1 stop

3:15 pm - 9:01 amPTY-CHS

16h 46m1 stop

$397American Airlines

Find Deal

Mon, Oct 20 - Mon, Oct 27

7:57 pm - 1:49 pmCHS-PTY

17h 52m1 stop

2:49 pm - 11:59 pmPTY-CHS

9h 10m1 stop

$398American Airlines

Find Deal

Sun, Nov 2 - Fri, Nov 7

11:00 am - 8:02 pmCHS-PTY

9h 02m1 stop

11:55 pm - 9:50 amPTY-CHS

9h 55m1 stop

$409United Airlines

Find Deal

Fri, Jan 16 - Sun, Feb 1

7:00 am - 6:37 pmCHS-PTY

12h 37m1 stop

3:30 pm - 10:15 pmPTY-CHS

29h 45m1 stop

$463United Airlines

Find Deal

Thu, Oct 2 - Sun, Oct 5

10:11 am - 8:19 pmCHS-PTY

11h 08m1 stop

12:03 pm - 9:28 amPTY-CHS

20h 25m2 stops

$497Multiple Airlines

Find Deal

Mon, Oct 6 - Mon, Oct 13

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

American Airlines

Nov 3

CHS5:39 pmCharleston

20h 10m

2 stops

PTY1:49 pmPanama City Tocumen Intl

Nov 7

PTY2:49 pmPanama City Tocumen Intl

17h 40m

2 stops

CHS8:29 amCharleston

$374

Find similar

American Airlines

Nov 3

CHS7:57 pmCharleston

17h 52m

1 stop

PTY1:49 pmPanama City Tocumen Intl

Nov 7

PTY2:49 pmPanama City Tocumen Intl

9h 10m

1 stop

CHS11:59 pmCharleston

$377

Find similar

American Airlines

Oct 15

CHS7:41 pmCharleston

19h 22m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 22

PTY3:15 pmPanama City Tocumen Intl

16h 01m

2 stops

CHS8:16 amCharleston

$382

Find similar

United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

United Airlines

Nov 24

CHS6:30 amCharleston

8h 15m

1 stop

PTY2:45 pmPanama City Tocumen Intl

Nov 30

PTY8:55 amPanama City Tocumen Intl

13h 04m

1 stop

CHS9:59 pmCharleston

$389

Find similar

United Airlines

Jan 16

CHS11:00 amCharleston

9h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Feb 1

PTY11:55 pmPanama City Tocumen Intl

9h 55m

1 stop

CHS9:50 amCharleston

$409

Find similar

United Airlines

Oct 2

CHS7:00 amCharleston

12h 37m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 5

PTY3:30 pmPanama City Tocumen Intl

29h 45m

1 stop

CHS10:15 pmCharleston

$463

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/3

5:39 pm-1:49 pm

2 stops20h 10m

Panama City Tocumen Intl

Fri 11/7

2:49 pm-8:29 am

2 stops17h 40m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/3

7:57 pm-1:49 pm

1 stop17h 52m

Panama City Tocumen Intl

Fri 11/7

2:49 pm-11:59 pm

1 stop9h 10m

$377

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 10/15

7:41 pm-2:03 pm

2 stops19h 22m

Panama City Tocumen Intl

Wed 10/22

3:15 pm-8:16 am

2 stops16h 01m

$382

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/24

6:30 am-2:45 pm

1 stop8h 15m

Panama City Tocumen Intl

Sun 11/30

8:55 am-9:59 pm

1 stop13h 04m

$389

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:31 pm-12:10 pm

2 stops18h 39m

Panama City Tocumen Intl

Tue 3/17

1:50 pm-10:59 am

2 stops20h 09m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 10/20

7:44 pm-2:03 pm

1 stop19h 19m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-9:01 am

1 stop16h 46m

$397

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 11/2

7:57 pm-1:49 pm

1 stop17h 52m

Panama City Tocumen Intl

Fri 11/7

2:49 pm-11:59 pm

1 stop9h 10m

$398

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

Sun 2/1

11:55 pm-9:50 am

1 stop9h 55m

$409

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/2

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sun 10/5

3:30 pm-10:15 pm

1 stop29h 45m

$463

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 10/6

10:11 am-8:19 pm

1 stop11h 08m

Panama City Tocumen Intl

Mon 10/13

12:03 pm-9:28 am

2 stops20h 25m

$497

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of November is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $424. If you don’t want to visit Panama in November, then you should wait until September to fly from Charleston, when ticket prices are also cheap, with an average price of $444.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Charleston. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Charleston to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to Panama flight.

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Direct flights	None

There are no direct flights from Charleston to Panama. There are no popular flight routes from Charleston to Panama.

Search flight deals

When did momondo last update prices for flights from Charleston Airport to Panama?
Prices for flights from Charleston Airport to Panama are updated daily.
How many operators does momondo search for flights from Charleston Airport to Panama?
As of September 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.
How old do you have to be to fly from Charleston Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.
What documentation or ID do you need to fly to Panama?
The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $361	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
Delta	PriceFrom $369	Free Cancellation	Rating 7.9 7,964 reviews	Search Delta flights
United Airlines	PriceFrom $391	Free Cancellation	Rating 7.4 8,926 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

It is quick and easy to find Charleston to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Panama?

Once you have performed a search for Charleston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Popular cities in Panama

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Cheap flights from Charleston to Panama from $374

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama departing on 11/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

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Price Alerts

Price Alerts

Find the cheapest flights from Charleston to Panama

Cheap round-trip flights

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

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How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to Panama flight.

What airlines fly to Panama?

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Direct flights

When did momondo last update prices for flights from Charleston Airport to Panama?

How many operators does momondo search for flights from Charleston Airport to Panama?

How old do you have to be to fly from Charleston Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to Panama?

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo