What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Charleston according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Charleston to Panama?

United Airlines and American Airlines are the most popular carriers operating from Charleston to Panama

When did momondo last update prices for flights from Charleston Airport to Panama?

Prices for flights from Charleston Airport to Panama are updated daily.

How many operators does momondo search for flights from Charleston Airport to Panama?

As of December 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.

How old do you have to be to fly from Charleston Airport to Panama?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.

What documentation or ID do you need to fly to Panama?

The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$152 Cheap Flights from Charleston to Panama in 2025/26

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Round-trip

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Cheap round-trip flights

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11:00 am - 8:02 pm

CHS

PTY

9h 02m1 stop

11:35 am - 4:17 pm

PTY

CHS

28h 42m1 stop

$378United Airlines

Mon, Jan 26 - Thu, Jan 29

5:07 pm - 5:07 pm

CHS

PTY

24h 00m1 stop

3:41 pm - 9:58 pm

PTY

CHS

29h 17m1 stop

$386United Airlines

Mon, Feb 23 - Mon, Mar 9

7:02 pm - 2:22 pm

CHS

PTY

20h 20m2 stops

3:13 pm - 11:59 pm

PTY

CHS

7h 46m1 stop

$394American Airlines

Sat, Mar 14 - Tue, Mar 17

7:20 pm - 3:52 pm

CHS

PTY

20h 32m1 stop

2:27 pm - 11:58 pm

PTY

CHS

9h 31m1 stop

$398American Airlines

Fri, Jan 23 - Fri, Jan 30

10:57 am - 1:50 pm

CHS

PTY

26h 53m1 stop

3:13 pm - 12:21 pm

PTY

CHS

20h 08m2 stops

$402American Airlines

Mon, Feb 23 - Mon, Mar 9

6:30 am - 7:38 pm

CHS

PTY

13h 08m1 stop

4:41 pm - 4:17 pm

PTY

CHS

23h 36m1 stop

$411United Airlines

Mon, Jan 5 - Mon, Jan 12

5:41 pm - 1:27 pm

CHS

PTY

19h 46m2 stops

4:50 pm - 8:47 am

PTY

CHS

15h 57m1 stop

$419American Airlines

Fri, Jan 16 - Sun, Feb 1

4:13 pm - 1:27 pm

CHS

PTY

21h 14m2 stops

2:27 pm - 10:16 am

PTY

CHS

19h 49m2 stops

$426American Airlines

Mon, Jan 5 - Mon, Jan 12

5:13 pm - 7:38 pm

CHS

PTY

26h 25m1 stop

4:41 pm - 9:57 pm

PTY

CHS

29h 16m1 stop

$427United Airlines

Fri, Jan 16 - Sun, Feb 1

8:07 pm - 1:27 pm

CHS

PTY

17h 20m1 stop

2:27 pm - 10:16 am

PTY

CHS

19h 49m2 stops

$435American Airlines

Mon, Jan 5 - Mon, Jan 12

United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

United Airlines

Jan 26

CHS11:00 amCharleston

9h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Jan 29

PTY11:35 amPanama City Tocumen Intl

28h 42m

1 stop

CHS4:17 pmCharleston

$378

Find similar

United Airlines

Feb 23

CHS5:07 pmCharleston

24h 00m

1 stop

PTY5:07 pmPanama City Tocumen Intl

Mar 9

PTY3:41 pmPanama City Tocumen Intl

29h 17m

1 stop

CHS9:58 pmCharleston

$386

Find similar

United Airlines

Jan 5

CHS6:30 amCharleston

13h 08m

1 stop

PTY7:38 pmPanama City Tocumen Intl

Jan 12

PTY4:41 pmPanama City Tocumen Intl

23h 36m

1 stop

CHS4:17 pmCharleston

$411

Find similar

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

American Airlines

Mar 14

CHS7:02 pmCharleston

20h 20m

2 stops

PTY2:22 pmPanama City Tocumen Intl

Mar 17

PTY3:13 pmPanama City Tocumen Intl

7h 46m

1 stop

CHS11:59 pmCharleston

$394

Find similar

American Airlines

Jan 23

CHS7:20 pmCharleston

20h 32m

1 stop

PTY3:52 pmPanama City Tocumen Intl

Jan 30

PTY2:27 pmPanama City Tocumen Intl

9h 31m

1 stop

CHS11:58 pmCharleston

$398

Find similar

American Airlines

Feb 23

CHS10:57 amCharleston

26h 53m

1 stop

PTY1:50 pmPanama City Tocumen Intl

Mar 9

PTY3:13 pmPanama City Tocumen Intl

20h 08m

2 stops

CHS12:21 pmCharleston

$402

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/26

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

Thu 1/29

11:35 am-4:17 pm

1 stop28h 42m

$378

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 2/23

5:07 pm-5:07 pm

1 stop24h 00m

Panama City Tocumen Intl

Mon 3/9

3:41 pm-9:58 pm

1 stop29h 17m

$386

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

7:02 pm-2:22 pm

2 stops20h 20m

Panama City Tocumen Intl

Tue 3/17

3:13 pm-11:59 pm

1 stop7h 46m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/23

7:20 pm-3:52 pm

1 stop20h 32m

Panama City Tocumen Intl

Fri 1/30

2:27 pm-11:58 pm

1 stop9h 31m

$398

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 2/23

10:57 am-1:50 pm

1 stop26h 53m

Panama City Tocumen Intl

Mon 3/9

3:13 pm-12:21 pm

2 stops20h 08m

$402

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

6:30 am-7:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Mon 1/12

4:41 pm-4:17 pm

1 stop23h 36m

$411

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

5:41 pm-1:27 pm

2 stops19h 46m

Panama City Tocumen Intl

Sun 2/1

4:50 pm-8:47 am

1 stop15h 57m

$419

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

4:13 pm-1:27 pm

2 stops21h 14m

Panama City Tocumen Intl

Mon 1/12

2:27 pm-10:16 am

2 stops19h 49m

$426

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

5:13 pm-7:38 pm

1 stop26h 25m

Panama City Tocumen Intl

Sun 2/1

4:41 pm-9:57 pm

1 stop29h 16m

$427

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

8:07 pm-1:27 pm

1 stop17h 20m

Panama City Tocumen Intl

Mon 1/12

2:27 pm-10:16 am

2 stops19h 49m

$435

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $389. If you don’t want to visit Panama in September, then you should wait until March to fly from Charleston, when ticket prices are also cheap, with an average price of $413.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Charleston. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Charleston to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 61% on your flight if you consider stops on a Charleston to Panama flight.

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Fastest flight time	8h 15m
Direct flights	None

The fastest flight from Charleston to Panama takes 8h 15m

There are no direct flights from Charleston to Panama. There are no popular flight routes from Charleston to Panama.

Search flight deals

When did momondo last update prices for flights from Charleston Airport to Panama?
Prices for flights from Charleston Airport to Panama are updated daily.
How many operators does momondo search for flights from Charleston Airport to Panama?
As of December 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.
How old do you have to be to fly from Charleston Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.
What documentation or ID do you need to fly to Panama?
The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $349	Free Cancellation	Rating 7.9 8,007 reviews	Search Delta flights
American Airlines	PriceFrom $373	Free Cancellation	Rating 7.2 11,048 reviews	Search American Airlines flights
United Airlines	PriceFrom $382	Free Cancellation	Rating 7.4 9,092 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

It is quick and easy to find Charleston to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Panama?

Once you have performed a search for Charleston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Popular cities in Panama

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Flights to Changuinola

Cheap flights from Charleston to Panama from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Charleston to Panama

Cheap round-trip flights

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United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

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Use the filters below to find and compare flights from Charleston to Panama that are best for you.

See travel insights to Panama from

How to get the cheapest flight ticket from Charleston to Panama

What is the cheapest month to fly to Panama?

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 61% on your flight if you consider stops on a Charleston to Panama flight.

What is the cheapest airline that flies from Charleston to Panama?

United Airlines and American Airlines are the most popular carriers operating from Charleston to Panama

What airlines fly to Panama?

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Fastest flight time

Direct flights

When did momondo last update prices for flights from Charleston Airport to Panama?

How many operators does momondo search for flights from Charleston Airport to Panama?

How old do you have to be to fly from Charleston Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to Panama?

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo