What is the cheapest airline that flies from Charleston to Panama?

American Airlines is the most popular carrier operating from Charleston to Panama

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Charleston according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to Panama?

Prices for flights from Charleston Airport to Panama are updated daily.

How many operators does momondo search for flights from Charleston Airport to Panama?

As of August 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.

How old do you have to be to fly from Charleston Airport to Panama?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.

What documentation or ID do you need to fly to Panama?

The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$158 Cheap Flights from Charleston to Panama in 2025

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Find the cheapest flights from Charleston to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

7:53 pm - 1:36 pmCHS-PTY

17h 43m2 stops

4:15 pm - 10:19 amPTY-CHS

18h 04m2 stops

$374American Airlines

Find Deal

Mon, Dec 1 - Thu, Dec 4

6:00 am - 2:00 pmCHS-PTY

9h 00m1 stop

3:15 pm - 11:59 pmPTY-CHS

7h 44m1 stop

$389American Airlines

Find Deal

Fri, Oct 10 - Mon, Oct 20

4:22 pm - 2:30 pmCHS-PTY

23h 08m2 stops

3:31 pm - 11:37 pmPTY-CHS

7h 06m1 stop

$394American Airlines

Find Deal

Sun, Aug 31 - Thu, Sep 4

7:50 pm - 2:30 pmCHS-PTY

19h 40m1 stop

3:31 pm - 11:37 pmPTY-CHS

7h 06m1 stop

$398American Airlines

Find Deal

Sun, Aug 31 - Thu, Sep 4

5:16 pm - 2:14 pmCHS-PTY

21h 58m1 stop

3:30 pm - 4:35 pmPTY-CHS

24h 05m1 stop

$406United Airlines

Find Deal

Thu, Sep 4 - Mon, Sep 8

6:30 am - 8:04 pmCHS-PTY

13h 34m1 stop

3:27 pm - 11:39 pmPTY-CHS

8h 12m1 stop

$409Delta

Find Deal

Fri, Jan 16 - Sun, Feb 1

7:08 am - 2:31 pmCHS-PTY

8h 23m1 stop

3:31 pm - 11:37 pmPTY-CHS

7h 06m1 stop

$414American Airlines

Find Deal

Sun, Sep 14 - Sun, Sep 21

6:30 am - 8:04 pmCHS-PTY

13h 34m1 stop

3:27 pm - 11:39 pmPTY-CHS

8h 12m1 stop

$426Delta

Find Deal

Fri, Jan 16 - Sun, Feb 1

5:40 pm - 12:35 pmCHS-PTY

18h 55m2 stops

3:40 pm - 10:45 amPTY-CHS

19h 05m3 stops

$672

Find Deal

Sun, Dec 7 - Mon, Dec 8

12:08 pm - 12:10 amCHS-PTY

13h 02m2 stops

11:00 am - 5:07 pmPTY-CHS

29h 07m3 stops

$701

Find Deal

Sun, Sep 14 - Sun, Sep 21

Delta flights from Charleston to Panama

Our best Delta deals on Charleston to Panama flight tickets

Delta

Jan 16

CHS6:30 amCharleston

13h 34m

1 stop

PTY8:04 pmPanama City Tocumen Intl

Feb 1

PTY3:27 pmPanama City Tocumen Intl

8h 12m

1 stop

CHS11:39 pmCharleston

$409

Find similar

Delta

Jan 16

CHS6:30 amCharleston

13h 34m

1 stop

PTY8:04 pmPanama City Tocumen Intl

Feb 1

PTY3:27 pmPanama City Tocumen Intl

8h 12m

1 stop

CHS11:39 pmCharleston

$426

Find similar

Delta

Nov 19

CHS5:30 amCharleston

8h 22m

1 stop

PTY1:52 pmPanama City Tocumen Intl

Nov 29

PTY8:05 amPanama City Tocumen Intl

7h 34m

1 stop

CHS3:39 pmCharleston

$681

Find similar

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

American Airlines

Dec 1

CHS7:53 pmCharleston

17h 43m

2 stops

PTY1:36 pmPanama City Tocumen Intl

Dec 4

PTY4:15 pmPanama City Tocumen Intl

18h 04m

2 stops

CHS10:19 amCharleston

$374

Find similar

American Airlines

Oct 10

CHS6:00 amCharleston

9h 00m

1 stop

PTY2:00 pmPanama City Tocumen Intl

Oct 20

PTY3:15 pmPanama City Tocumen Intl

7h 44m

1 stop

CHS11:59 pmCharleston

$389

Find similar

American Airlines

Aug 31

CHS4:22 pmCharleston

23h 08m

2 stops

PTY2:30 pmPanama City Tocumen Intl

Sep 4

PTY3:31 pmPanama City Tocumen Intl

7h 06m

1 stop

CHS11:37 pmCharleston

$394

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 12/1

7:53 pm-1:36 pm

2 stops17h 43m

Panama City Tocumen Intl

Thu 12/4

4:15 pm-10:19 am

2 stops18h 04m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 10/10

6:00 am-2:00 pm

1 stop9h 00m

Panama City Tocumen Intl

Mon 10/20

3:15 pm-11:59 pm

1 stop7h 44m

$389

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 8/31

4:22 pm-2:30 pm

2 stops23h 08m

Panama City Tocumen Intl

Thu 9/4

3:31 pm-11:37 pm

1 stop7h 06m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 8/31

7:50 pm-2:30 pm

1 stop19h 40m

Panama City Tocumen Intl

Thu 9/4

3:31 pm-11:37 pm

1 stop7h 06m

$398

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 9/4

5:16 pm-2:14 pm

1 stop21h 58m

Panama City Tocumen Intl

Mon 9/8

3:30 pm-4:35 pm

1 stop24h 05m

$406

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

6:30 am-8:04 pm

1 stop13h 34m

Panama City Tocumen Intl

Sun 2/1

3:27 pm-11:39 pm

1 stop8h 12m

$409

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 9/14

7:08 am-2:31 pm

1 stop8h 23m

Panama City Tocumen Intl

Sun 9/21

3:31 pm-11:37 pm

1 stop7h 06m

$414

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

6:30 am-8:04 pm

1 stop13h 34m

Panama City Tocumen Intl

Sun 2/1

3:27 pm-11:39 pm

1 stop8h 12m

$426

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 12/7

5:40 pm-12:35 pm

2 stops18h 55m

Panama City Tocumen Intl

Mon 12/8

3:40 pm-10:45 am

3 stops19h 05m

$672

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 9/14

12:08 pm-12:10 am

2 stops13h 02m

Panama City Tocumen Intl

Sun 9/21

11:00 am-5:07 pm

3 stops29h 07m

$701

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of November is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $402. If you don’t want to visit Panama in November, then you should wait until July to fly from Charleston, when ticket prices are also cheap, with an average price of $406.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Charleston. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Charleston to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to Panama flight.

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Best Price Found	$158
Fastest flight time	5h 46m
Direct flights	None
Airports in Panama	1 airport

The best one-way flight to Panama from Charleston in the past 72 hours is $158. The best round-trip flight deal from Charleston to Panama found on momondo in the last 72 hours is $374.

The fastest flight from Charleston to Panama takes 5h 46m

There are no direct flights from Charleston to Panama. Popular non-direct route for this connection is Charleston Airport - Panama City Tocumen Intl Airport.

There is 1 airport near Panama: Panama City Tocumen Intl (PTY)

Search flight deals

When did momondo last update prices for flights from Charleston Airport to Panama?
Prices for flights from Charleston Airport to Panama are updated daily.
How many operators does momondo search for flights from Charleston Airport to Panama?
As of August 2025, there are 3 operators available to choose from for flights from Charleston Airport to Panama.
How old do you have to be to fly from Charleston Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.
What documentation or ID do you need to fly to Panama?
The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $331	Free Cancellation	Rating 8.0 7,983 reviews	Search Delta flights
American Airlines	PriceFrom $362	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $391	Free Cancellation	Rating 7.4 8,904 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

It is quick and easy to find Charleston to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Panama?

Once you have performed a search for Charleston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Find better results for your trip to Panama

Popular cities in Panama

Flights to Panama Cityfrom $309

Flights to Bocas del Torofrom $593

Flights to Davidfrom $359

Flights to Changuinola

Cheap flights from Charleston to Panama from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama departing on 8/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Charleston to Panama

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Delta flights from Charleston to Panama

Our best Delta deals on Charleston to Panama flight tickets

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

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Use the filters below to find and compare flights from Charleston to Panama that are best for you.

See travel insights to Panama from

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of November is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $402. If you don’t want to visit Panama in November, then you should wait until July to fly from Charleston, when ticket prices are also cheap, with an average price of $406.

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on Charleston to Panama flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to Panama flight.

What is the cheapest airline that flies from Charleston to Panama?

American Airlines is the most popular carrier operating from Charleston to Panama

What airlines fly to Panama?

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Best Price Found

Fastest flight time

Direct flights

Airports in Panama

When did momondo last update prices for flights from Charleston Airport to Panama?

How many operators does momondo search for flights from Charleston Airport to Panama?

How old do you have to be to fly from Charleston Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to Panama?

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo