What is the cheapest airline that flies from Charleston to Panama?

American Airlines and United Airlines are the most popular carriers operating from Charleston to Panama

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Charleston according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to Panama?

Prices for flights from Charleston Airport to Panama are updated daily.

How many operators does momondo search for flights from Charleston Airport to Panama?

As of October 2026, there are 3 operators available to choose from for flights from Charleston Airport to Panama.

How old do you have to be to fly from Charleston Airport to Panama?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.

What documentation or ID do you need to fly to Panama?

The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$291 Cheap Flights from Charleston to Panama in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to Panama

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

14h 02m1 stop Newark

4:41 pm - 1:58 pmPTY Panama City Tocumen Intl-CHS Charleston

21h 17m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$649United Airlines

Mon, Jan 25 - Mon, Feb 15

7:51 pm - 2:45 pmCHS Charleston-PTY Panama City Tocumen Intl

18h 54m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

4:41 pm - 1:58 pmPTY Panama City Tocumen Intl-CHS Charleston

21h 17m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$649United Airlines

Mon, Jan 25 - Mon, Feb 15

6:00 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

14h 02m1 stop Newark

4:41 pm - 1:58 pmPTY Panama City Tocumen Intl-CHS Charleston

21h 17m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$652United Airlines

Thu, Feb 11 - Mon, Feb 15

6:05 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

13h 57m2 stops Chicago O'Hare Intl Newark

4:41 pm - 1:58 pmPTY Panama City Tocumen Intl-CHS Charleston

21h 17m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$652United Airlines

Thu, Feb 11 - Mon, Feb 15

7:51 pm - 5:12 pmCHS Charleston-PTY Panama City Tocumen Intl

21h 21m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

8:55 am - 11:04 amPTY Panama City Tocumen Intl-CHS Charleston

26h 09m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$669United Airlines

Mon, Feb 1 - Mon, Feb 22

8:19 pm - 1:26 pmCHS Charleston-PTY Panama City Tocumen Intl

17h 07m1 stop Miami

4:31 pm - 12:08 amPTY Panama City Tocumen Intl-CHS Charleston

7h 37m1 stop Miami

$681American Airlines

Mon, Jan 25 - Mon, Feb 15

6:56 pm - 2:30 pmCHS Charleston-PTY Panama City Tocumen Intl

20h 34m2 stops Charlotte Douglas Miami

1:49 pm - 11:38 amPTY Panama City Tocumen Intl-CHS Charleston

20h 49m2 stops Miami Philadelphia

$686American Airlines

Sat, Apr 3 - Thu, Apr 8

7:15 am - 12:47 pmCHS Charleston-PTY Panama City Tocumen Intl

6h 32m1 stop Miami

1:49 pm - 12:45 pmPTY Panama City Tocumen Intl-CHS Charleston

21h 56m2 stops Miami Charlotte Douglas

$686American Airlines

Sat, Apr 3 - Thu, Apr 8

7:21 am - 2:34 pmCHS Charleston-PTY Panama City Tocumen Intl

7h 13m1 stop Miami

3:13 pm - 10:13 pmPTY Panama City Tocumen Intl-CHS Charleston

7h 00m1 stop Miami

$691American Airlines

Fri, Nov 27 - Wed, Dec 2

12:45 pm - 2:10 amCHS Charleston-PTY Panama City Tocumen Intl

37h 25m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

4:10 pm - 6:00 pmPTY Panama City Tocumen Intl-CHS Charleston

25h 50m2 stops Bogotá El Dorado Fort Lauderdale

$1,003Multiple Airlines

Mon, Jan 25 - Mon, Feb 15

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United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

United Airlines

Jan 25

CHS7:51 pmCharleston

18h 54m

2 stops

PTY2:45 pmPanama City Tocumen Intl

Feb 15

PTY4:41 pmPanama City Tocumen Intl

21h 17m

2 stops

CHS1:58 pmCharleston

$649

United Airlines

Feb 11

CHS6:05 amCharleston

13h 57m

2 stops

PTY8:02 pmPanama City Tocumen Intl

Feb 15

PTY4:41 pmPanama City Tocumen Intl

21h 17m

2 stops

CHS1:58 pmCharleston

$652

United Airlines

Feb 1

CHS6:00 amCharleston

14h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Feb 22

PTY8:55 amPanama City Tocumen Intl

26h 09m

2 stops

CHS11:04 amCharleston

$669

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

American Airlines

Jan 25

CHS8:19 pmCharleston

17h 07m

1 stop

PTY1:26 pmPanama City Tocumen Intl

Feb 15

PTY4:31 pmPanama City Tocumen Intl

7h 37m

1 stop

CHS12:08 amCharleston

$681

American Airlines

Nov 27

CHS7:21 amCharleston

7h 13m

1 stop

PTY2:34 pmPanama City Tocumen Intl

Dec 2

PTY3:13 pmPanama City Tocumen Intl

7h 00m

1 stop

CHS10:13 pmCharleston

$691

American Airlines

Feb 11

CHS7:41 pmCharleston

19h 49m

1 stop

PTY3:30 pmPanama City Tocumen Intl

Feb 15

PTY4:31 pmPanama City Tocumen Intl

7h 37m

1 stop

CHS12:08 amCharleston

$692

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/25

6:00 am-8:02 pm

1 stop14h 02m

Panama City Tocumen Intl

Mon 2/15

4:41 pm-1:58 pm

2 stops21h 17m

$649

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/25

7:51 pm-2:45 pm

2 stops18h 54m

Panama City Tocumen Intl

Mon 2/15

4:41 pm-1:58 pm

2 stops21h 17m

$649

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Thu 2/11

6:00 am-8:02 pm

1 stop14h 02m

Panama City Tocumen Intl

Mon 2/15

4:41 pm-1:58 pm

2 stops21h 17m

$652

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Thu 2/11

6:05 am-8:02 pm

2 stops13h 57m

Panama City Tocumen Intl

Mon 2/15

4:41 pm-1:58 pm

2 stops21h 17m

$652

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 2/1

7:51 pm-5:12 pm

2 stops21h 21m

Panama City Tocumen Intl

Mon 2/22

8:55 am-11:04 am

2 stops26h 09m

$669

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/25

8:19 pm-1:26 pm

1 stop17h 07m

Panama City Tocumen Intl

Mon 2/15

4:31 pm-12:08 am

1 stop7h 37m

$681

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Sat 4/3

6:56 pm-2:30 pm

2 stops20h 34m

Panama City Tocumen Intl

Thu 4/8

1:49 pm-11:38 am

2 stops20h 49m

$686

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Sat 4/3

7:15 am-12:47 pm

1 stop6h 32m

Panama City Tocumen Intl

Thu 4/8

1:49 pm-12:45 pm

2 stops21h 56m

$686

Quickest round-trip

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Fri 11/27

7:21 am-2:34 pm

1 stop7h 13m

Panama City Tocumen Intl

Wed 12/2

3:13 pm-10:13 pm

1 stop7h 00m

$691

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/25

12:45 pm-2:10 am

2 stops37h 25m

Panama City Tocumen Intl

Mon 2/15

4:10 pm-6:00 pm

2 stops25h 50m

$1,003

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from Charleston, with most prices found around $487. If you don’t want to visit Panama in March, then you should wait until May to fly from Charleston, when ticket prices are also cheap, with an average price of $536.

Cheap Charleston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama

Best Price Found	$291
Fastest flight time	6h 32m
Direct flights	None

The best one-way flight to Panama from Charleston in the past 72 hours is $291. The best round-trip flight deal from Charleston to Panama found on momondo in the last 72 hours is $649.

The fastest flight from Charleston to Panama takes 6h 32m

There are no direct flights from Charleston to Panama. There are no popular flight routes from Charleston to Panama.

Search flight deals

Frequently asked questions about flying from Charleston to Panama

When did momondo last update prices for flights from Charleston Airport to Panama?
Prices for flights from Charleston Airport to Panama are updated daily.
How many operators does momondo search for flights from Charleston Airport to Panama?
As of October 2026, there are 3 operators available to choose from for flights from Charleston Airport to Panama.
How old do you have to be to fly from Charleston Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama.
What documentation or ID do you need to fly to Panama?
The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $299	Free Cancellation	Rating 7.8 8,668 reviews	Search Delta flights
United Airlines	PriceFrom $369	Free Cancellation	Rating 7.3 10,419 reviews	Search United Airlines flights
American Airlines	PriceFrom $487	Free Cancellation	Rating 7.0 12,190 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama?

It is quick and easy to find Charleston to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Charleston to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Panama?

Once you have performed a search for Charleston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

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Popular cities in Panama

Flights to Panama Cityfrom $517

Flights to Bocas del Torofrom $765

Flights to Davidfrom $485

Flights to Changuinola

Cheap flights from Charleston to Panama from $291

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama departing on 2/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Charleston to Panama

Our best United Airlines deals on Charleston to Panama flight tickets

American Airlines flights from Charleston to Panama

Our best American Airlines deals on Charleston to Panama flight tickets

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How to get the cheapest flight ticket from Charleston to Panama

What is the cheapest month to fly to Panama?

What is the cheapest airline that flies from Charleston to Panama?

What airlines fly to Panama?

Cheap Charleston to Panama flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Charleston to Panama

Best airlines flying from Charleston to Panama

Compare and see reviews for airlines that fly from Charleston to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Charleston flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

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Explore popular destinations other users love

According to popular flight searches on momondo this year