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Cheap flights from St. Louis to Santiago from $301

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 1/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
1:00 pm - 7:00 amSTL-SCL
16h 00m2 stops
LATAM Airlines Logo
11:25 pm - 7:14 pmSCL-STL
21h 49m2 stops
$735LATAM Airlines
Find Deal
qua, mar 11 - seg, mar 23
LATAM Airlines Logo
10:00 am - 5:35 amSTL-SCL
17h 35m2 stops
LATAM Airlines Logo
11:25 pm - 7:14 pmSCL-STL
21h 49m2 stops
$738LATAM Airlines
Find Deal
qua, mar 11 - seg, mar 23
United Airlines Logo
6:00 am - 7:50 amSTL-SCL
23h 50m1 stop
United Airlines Logo
9:45 pm - 9:24 amSCL-STL
13h 39m1 stop
$756United Airlines
Find Deal
qua, mar 11 - seg, mar 23
United Airlines Logo
6:00 am - 7:50 amSTL-SCL
23h 50m1 stop
United Airlines Logo
9:45 pm - 9:24 amSCL-STL
13h 39m1 stop
$758United Airlines
Find Deal
qua, mar 11 - seg, mar 23
Delta Logo
7:05 am - 7:40 amSTL-SCL
21h 35m1 stop
Delta Logo
9:30 pm - 8:24 amSCL-STL
13h 54m1 stop
$764Delta
Find Deal
qui, dez 11 - seg, dez 15
Delta Logo
6:00 am - 4:30 amSTL-SCL
20h 30m2 stops
Delta Logo
11:15 pm - 4:01 pmSCL-STL
18h 46m1 stop
$804Delta
Find Deal
seg, mar 9 - sex, mar 20
American Airlines Logo
11:37 am - 7:50 amSTL-SCL
17h 13m2 stops
American Airlines Logo
10:15 pm - 12:27 pmSCL-STL
17h 12m2 stops
$849American Airlines
Find Deal
dom, fev 1 - sáb, fev 14
American Airlines Logo
6:00 am - 8:15 amSTL-SCL
23h 15m1 stop
American Airlines Logo
10:30 pm - 4:14 pmSCL-STL
20h 44m1 stop
$854American Airlines
Find Deal
seg, jan 19 - sex, jan 30
Multiple Airlines Logo
2:47 pm - 1:09 amSTL-SCL
31h 22m3 stops
Multiple Airlines Logo
3:45 pm - 1:52 pmSCL-STL
25h 07m3 stops
$971Multiple Airlines
Find Deal
dom, dez 7 - sáb, dez 13
Multiple Airlines Logo
3:30 pm - 3:43 amSTL-SCL
33h 13m2 stops
Multiple Airlines Logo
6:40 am - 3:26 pmSCL-STL
35h 46m2 stops
$1,036Multiple Airlines
Find Deal
sex, dez 12 - qui, jan 8

United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets
United Airlines
Mar 11
STL6:00 amLambert-St Louis
23h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 23
SCL9:45 pmSantiago Arturo Merino Benitez
13h 39m
1 stop
STL9:24 amLambert-St Louis
$756
Find similar
United Airlines
Mar 11
STL6:00 amLambert-St Louis
23h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 23
SCL9:45 pmSantiago Arturo Merino Benitez
13h 39m
1 stop
STL9:24 amLambert-St Louis
$758
Find similar
United Airlines
Nov 19
STL6:30 amLambert-St Louis
23h 20m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Nov 26
SCL10:45 pmSantiago Arturo Merino Benitez
16h 43m
2 stops
STL12:28 pmLambert-St Louis
$769
Find similar

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets
LATAM Airlines
Mar 11
STL1:00 pmLambert-St Louis
16h 00m
2 stops
SCL7:00 amSantiago Arturo Merino Benitez
Mar 23
SCL11:25 pmSantiago Arturo Merino Benitez
21h 49m
2 stops
STL7:14 pmLambert-St Louis
$735
Find similar
LATAM Airlines
Mar 11
STL10:00 amLambert-St Louis
17h 35m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 23
SCL11:25 pmSantiago Arturo Merino Benitez
21h 49m
2 stops
STL7:14 pmLambert-St Louis
$738
Find similar
LATAM Airlines
Mar 11
STL1:00 pmLambert-St Louis
14h 35m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 23
SCL11:25 pmSantiago Arturo Merino Benitez
21h 49m
2 stops
STL7:14 pmLambert-St Louis
$739
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated novembro 6, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

qua 3/11

1:00 pm-7:00 am

2 stops16h 00m

Santiago Arturo Merino Benitez

seg 3/23

11:25 pm-7:14 pm

2 stops21h 49m

$735

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

qua 3/11

10:00 am-5:35 am

2 stops17h 35m

Santiago Arturo Merino Benitez

seg 3/23

11:25 pm-7:14 pm

2 stops21h 49m

$738

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

qua 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

seg 3/23

9:45 pm-9:24 am

1 stop13h 39m

$756

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

qua 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

seg 3/23

9:45 pm-9:24 am

1 stop13h 39m

$758

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

qui 12/11

7:05 am-7:40 am

1 stop21h 35m

Santiago Arturo Merino Benitez

seg 12/15

9:30 pm-8:24 am

1 stop13h 54m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

seg 3/9

6:00 am-4:30 am

2 stops20h 30m

Santiago Arturo Merino Benitez

sex 3/20

11:15 pm-4:01 pm

1 stop18h 46m

$804

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom 2/1

11:37 am-7:50 am

2 stops17h 13m

Santiago Arturo Merino Benitez

sáb 2/14

10:15 pm-12:27 pm

2 stops17h 12m

$849

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

seg 1/19

6:00 am-8:15 am

1 stop23h 15m

Santiago Arturo Merino Benitez

sex 1/30

10:30 pm-4:14 pm

1 stop20h 44m

$854

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

dom 12/7

2:47 pm-1:09 am

3 stops31h 22m

Santiago Arturo Merino Benitez

sáb 12/13

3:45 pm-1:52 pm

3 stops25h 07m

$971

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

sex 12/12

3:30 pm-3:43 am

2 stops33h 13m

Santiago Arturo Merino Benitez

qui 1/8

6:40 am-3:26 pm

2 stops35h 46m

$1,036

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, July is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $878. If you don’t want to visit Santiago in July, then you should wait until March to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $955. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,189.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from St. Louis to Santiago when you can find flight prices for as low as $982. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,074 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $995 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from St. Louis for as low as $740 on momondo.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Direct flights

None
There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.
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  • How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?

    The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 00m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santiago?

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $689Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights
United AirlinesPriceFrom $764Free CancellationRating
7.4
9,000 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $773Free CancellationRating
7.5
1,874 reviews
Search LATAM Airlines flights
DeltaPriceFrom $803Free CancellationRating
7.9
8,005 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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