Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines is the most popular carrier operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$450 Cheap Flights from St. Louis to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:05 pm - 12:15 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 10m1 stop Toronto Pearson Intl

9:55 pm - 3:26 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

20h 31m1 stop Toronto Pearson Intl

$1,079Air Canada

Mon, Nov 30 - Mon, Dec 7

4:05 pm - 6:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 45m2 stops Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl

9:55 pm - 3:26 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

20h 31m1 stop Toronto Pearson Intl

$1,082Air Canada

Mon, Nov 30 - Mon, Dec 7

12:20 pm - 8:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 45m1 stop Miami

8:35 pm - 9:20 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 45m1 stop Miami

$1,088American Airlines

Sat, Apr 3 - Sat, Apr 17

11:11 am - 8:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 54m2 stops Charlotte Douglas Miami

8:35 pm - 3:15 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 40m2 stops Miami New York LaGuardia

$1,092American Airlines

Sat, Apr 3 - Sat, Apr 17

12:20 pm - 8:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 45m1 stop Miami

8:35 pm - 6:04 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 29m2 stops Miami Charlotte Douglas

$1,092American Airlines

Sat, Apr 3 - Sat, Apr 17

6:13 pm - 6:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

33h 37m3 stops Orlando Philadelphia Montreal Pierre Elliott Trudeau Intl

4:15 pm - 12:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

34h 57m2 stops Bogotá El Dorado Orlando

$1,110Multiple Airlines

Wed, Dec 2 - Wed, Dec 9

3:48 pm - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

11h 52m1 stop Atlanta Hartsfield-Jackson

9:50 pm - 8:52 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

14h 02m1 stop Atlanta Hartsfield-Jackson

$1,113LATAM Airlines

Tue, Dec 29 - Fri, Jan 15

3:40 pm - 5:40 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 00m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

12:48 am - 6:01 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

20h 13m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,116LATAM Airlines

Mon, Feb 15 - Mon, Mar 1

2:31 pm - 11:15 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 44m2 stops Atlanta Hartsfield-Jackson Sao Paulo Guarulhos Intl

6:30 pm - 11:29 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 59m2 stops Sao Paulo Guarulhos Intl Atlanta Hartsfield-Jackson

$1,138Delta

Sun, Nov 29 - Sun, Dec 6

10:30 am - 7:30 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 00m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

8:25 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

16h 23m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,138Delta

Sat, Mar 13 - Fri, Mar 19

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American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Apr 3

STL12:20 pmLambert-St Louis

17h 45m

1 stop

SCL8:05 amSantiago Arturo Merino Benitez

Apr 17

SCL8:35 pmSantiago Arturo Merino Benitez

13h 45m

1 stop

STL9:20 amLambert-St Louis

$1,088

American Airlines

Apr 3

STL11:11 amLambert-St Louis

18h 54m

2 stops

SCL8:05 amSantiago Arturo Merino Benitez

Apr 17

SCL8:35 pmSantiago Arturo Merino Benitez

19h 40m

2 stops

STL3:15 pmLambert-St Louis

$1,092

American Airlines

Mar 13

STL12:20 pmLambert-St Louis

17h 40m

1 stop

SCL9:00 amSantiago Arturo Merino Benitez

Mar 26

SCL10:15 pmSantiago Arturo Merino Benitez

19h 33m

2 stops

STL3:48 pmLambert-St Louis

$1,131

Air Canada flights from St. Louis to Santiago

Our best Air Canada deals on St. Louis to Santiago flight tickets

Air Canada

Nov 30

STL4:05 pmLambert-St Louis

17h 10m

1 stop

SCL12:15 pmSantiago Arturo Merino Benitez

Dec 7

SCL9:55 pmSantiago Arturo Merino Benitez

20h 31m

1 stop

STL3:26 pmLambert-St Louis

$1,079

Air Canada

Nov 30

STL4:05 pmLambert-St Louis

35h 45m

2 stops

SCL6:50 amSantiago Arturo Merino Benitez

Dec 7

SCL9:55 pmSantiago Arturo Merino Benitez

20h 31m

1 stop

STL3:26 pmLambert-St Louis

$1,082

Air Canada

Dec 7

STL4:05 pmLambert-St Louis

17h 10m

1 stop

SCL12:15 pmSantiago Arturo Merino Benitez

Dec 10

SCL9:55 pmSantiago Arturo Merino Benitez

20h 31m

1 stop

STL3:26 pmLambert-St Louis

$1,342

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 11/30

4:05 pm-12:15 pm

1 stop17h 10m

Santiago Arturo Merino Benitez

Mon 12/7

9:55 pm-3:26 pm

1 stop20h 31m

$1,079

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 11/30

4:05 pm-6:50 am

2 stops35h 45m

Santiago Arturo Merino Benitez

Mon 12/7

9:55 pm-3:26 pm

1 stop20h 31m

$1,082

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 4/3

12:20 pm-8:05 am

1 stop17h 45m

Santiago Arturo Merino Benitez

Sat 4/17

8:35 pm-9:20 am

1 stop13h 45m

$1,088

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 4/3

11:11 am-8:05 am

2 stops18h 54m

Santiago Arturo Merino Benitez

Sat 4/17

8:35 pm-3:15 pm

2 stops19h 40m

$1,092

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 4/3

12:20 pm-8:05 am

1 stop17h 45m

Santiago Arturo Merino Benitez

Sat 4/17

8:35 pm-6:04 pm

2 stops22h 29m

$1,092

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 12/2

6:13 pm-6:50 am

3 stops33h 37m

Santiago Arturo Merino Benitez

Wed 12/9

4:15 pm-12:12 am

2 stops34h 57m

$1,110

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 12/29

3:48 pm-6:40 am

1 stop11h 52m

Santiago Arturo Merino Benitez

Fri 1/15

9:50 pm-8:52 am

1 stop14h 02m

$1,113

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

3:40 pm-5:40 pm

2 stops23h 00m

Santiago Arturo Merino Benitez

Mon 3/1

12:48 am-6:01 pm

2 stops20h 13m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 11/29

2:31 pm-11:15 am

2 stops17h 44m

Santiago Arturo Merino Benitez

Sun 12/6

6:30 pm-11:29 am

2 stops19h 59m

$1,138

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 3/13

10:30 am-7:30 am

2 stops18h 00m

Santiago Arturo Merino Benitez

Fri 3/19

8:25 pm-10:48 am

2 stops16h 23m

$1,138

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $755. If you don’t want to visit Santiago in March, then you should wait until October to fly from St. Louis, when ticket prices are also cheap, with an average price of $995.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$450
Fastest flight time	13h 00m
Direct flights	None

The best one-way flight to Santiago from St. Louis in the past 72 hours is $450. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $1,079.

The fastest flight from St. Louis to Santiago takes 13h 00m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 13h 00m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 49% of the total bookings. Other popular airlines include American Airlines with 30% and LATAM Airlines with 21%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.0 12,174 reviews	Search American Airlines flights
Delta	PriceFrom $755	Free Cancellation	Rating 7.8 8,650 reviews	Search Delta flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,973 reviews	Search LATAM Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.