Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines and LATAM Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of May 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$603 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $1,292 to $1,088. The lowest price recently found on this route was $1,061.

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Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:19 pm - 10:43 pm

STL

SCL

53h 24m

2 stops

9:30 am - 2:39 pm

SCL

STL

30h 09m

1 stop

$1,061Multiple Airlines

Fri, May 15 - Sun, Jun 7

4:19 pm - 11:26 pm

STL

SCL

54h 07m

2 stops

9:30 am - 2:39 pm

SCL

STL

30h 09m

1 stop

$1,074Multiple Airlines

Mon, May 25 - Sun, Jun 7

11:00 am - 7:00 am

STL

SCL

19h 00m

1 stop

8:30 pm - 10:45 am

SCL

STL

15h 15m

1 stop

$1,075American Airlines

Wed, Jul 22 - Thu, Aug 6

10:31 am - 7:00 am

STL

SCL

19h 29m

2 stops

8:30 pm - 1:02 pm

SCL

STL

17h 32m

2 stops

$1,080American Airlines

Wed, Jul 22 - Thu, Aug 6

10:51 am - 6:00 am

STL

SCL

18h 09m

2 stops

8:40 pm - 9:43 am

SCL

STL

14h 03m

1 stop

$1,127LATAM Airlines

Tue, Jul 21 - Thu, Aug 6

3:58 pm - 7:15 am

STL

SCL

14h 17m

1 stop

8:40 pm - 9:43 am

SCL

STL

14h 03m

1 stop

$1,135Delta

Tue, Jul 21 - Wed, Aug 5

10:51 am - 4:50 am

STL

SCL

16h 59m

2 stops

11:00 pm - 4:14 pm

SCL

STL

18h 14m

2 stops

$1,140Delta

Tue, Jul 21 - Thu, Aug 6

4:19 pm - 3:00 am

STL

SCL

33h 41m

2 stops

9:30 am - 2:39 pm

SCL

STL

30h 09m

1 stop

$1,156Multiple Airlines

Sun, May 24 - Sun, Jun 7

4:19 pm - 1:35 pm

STL

SCL

44h 16m

2 stops

9:30 am - 2:39 pm

SCL

STL

30h 09m

1 stop

$1,161Multiple Airlines

Thu, May 14 - Sun, Jun 7

3:58 pm - 7:15 am

STL

SCL

14h 17m

1 stop

6:45 pm - 12:30 pm

SCL

STL

18h 45m

2 stops

$1,172LATAM Airlines

Tue, Jul 21 - Fri, Aug 7

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Jul 22

STL11:00 amLambert-St Louis

19h 00m

1 stop

SCL7:00 amSantiago Arturo Merino Benitez

Aug 6

SCL8:30 pmSantiago Arturo Merino Benitez

15h 15m

1 stop

STL10:45 amLambert-St Louis

$1,075

American Airlines

Jul 22

STL10:31 amLambert-St Louis

19h 29m

2 stops

SCL7:00 amSantiago Arturo Merino Benitez

Aug 6

SCL8:30 pmSantiago Arturo Merino Benitez

17h 32m

2 stops

STL1:02 pmLambert-St Louis

$1,080

American Airlines

Sep 2

STL11:35 amLambert-St Louis

18h 15m

1 stop

SCL6:50 amSantiago Arturo Merino Benitez

Sep 7

SCL9:30 pmSantiago Arturo Merino Benitez

15h 15m

1 stop

STL10:45 amLambert-St Louis

$1,245

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Jul 21

STL10:51 amLambert-St Louis

18h 09m

2 stops

SCL6:00 amSantiago Arturo Merino Benitez

Aug 6

SCL8:40 pmSantiago Arturo Merino Benitez

14h 03m

1 stop

STL9:43 amLambert-St Louis

$1,127

LATAM Airlines

Jul 21

STL3:58 pmLambert-St Louis

14h 17m

1 stop

SCL7:15 amSantiago Arturo Merino Benitez

Aug 7

SCL6:45 pmSantiago Arturo Merino Benitez

18h 45m

2 stops

STL12:30 pmLambert-St Louis

$1,172

LATAM Airlines

Jul 3

STL10:51 amLambert-St Louis

18h 09m

2 stops

SCL6:00 amSantiago Arturo Merino Benitez

Jul 11

SCL6:45 pmSantiago Arturo Merino Benitez

18h 32m

2 stops

STL12:17 pmLambert-St Louis

$1,189

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 5/15

4:19 pm-10:43 pm

2 stops53h 24m

Santiago Arturo Merino Benitez

Sun 6/7

9:30 am-2:39 pm

1 stop30h 09m

$1,061

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 5/25

4:19 pm-11:26 pm

2 stops54h 07m

Santiago Arturo Merino Benitez

Sun 6/7

9:30 am-2:39 pm

1 stop30h 09m

$1,074

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 7/22

11:00 am-7:00 am

1 stop19h 00m

Santiago Arturo Merino Benitez

Thu 8/6

8:30 pm-10:45 am

1 stop15h 15m

$1,075

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 7/22

10:31 am-7:00 am

2 stops19h 29m

Santiago Arturo Merino Benitez

Thu 8/6

8:30 pm-1:02 pm

2 stops17h 32m

$1,080

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/21

10:51 am-6:00 am

2 stops18h 09m

Santiago Arturo Merino Benitez

Thu 8/6

8:40 pm-9:43 am

1 stop14h 03m

$1,127

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/21

3:58 pm-7:15 am

1 stop14h 17m

Santiago Arturo Merino Benitez

Wed 8/5

8:40 pm-9:43 am

1 stop14h 03m

$1,135

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/21

10:51 am-4:50 am

2 stops16h 59m

Santiago Arturo Merino Benitez

Thu 8/6

11:00 pm-4:14 pm

2 stops18h 14m

$1,140

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 5/24

4:19 pm-3:00 am

2 stops33h 41m

Santiago Arturo Merino Benitez

Sun 6/7

9:30 am-2:39 pm

1 stop30h 09m

$1,156

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/14

4:19 pm-1:35 pm

2 stops44h 16m

Santiago Arturo Merino Benitez

Sun 6/7

9:30 am-2:39 pm

1 stop30h 09m

$1,161

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 7/21

3:58 pm-7:15 am

1 stop14h 17m

Santiago Arturo Merino Benitez

Fri 8/7

6:45 pm-12:30 pm

2 stops18h 45m

$1,172

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $793. If you don’t want to visit Santiago in March, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	12h 55m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 12h 55m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 55m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of May 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 44% of the total bookings. Other popular airlines include American Airlines with 30% and LATAM Airlines with 26%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.9 8,459 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,668 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,915 reviews	Search LATAM Airlines flights

Viña del Mar

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Santa Cruz

Valle Nevado

Pichilemu

San Fernando

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.