What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

Delta and American Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$663 Cheap Flights from St. Louis to Santiago in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:00 am - 8:00 am

STL

SCL

25h 00m

1 stop

10:15 pm - 9:47 pm

SCL

STL

26h 32m

1 stop

$990American Airlines

Wed, Sep 9 - Mon, Nov 16

8:30 am - 8:50 am

STL

SCL

21h 20m

1 stop

10:45 pm - 4:44 pm

SCL

STL

20h 59m

1 stop

$995United Airlines

Wed, Nov 18 - Tue, Dec 15

2:25 pm - 8:15 am

STL

SCL

15h 50m

1 stop

11:10 pm - 10:51 am

SCL

STL

14h 41m

1 stop

$995LATAM Airlines

Wed, Oct 21 - Wed, Nov 4

12:46 pm - 8:00 am

STL

SCL

17h 14m

2 stops

10:15 pm - 2:04 pm

SCL

STL

18h 49m

2 stops

$995American Airlines

Wed, Sep 9 - Mon, Nov 16

1:08 pm - 8:50 am

STL

SCL

16h 42m

2 stops

10:45 pm - 4:44 pm

SCL

STL

20h 59m

1 stop

$995United Airlines

Wed, Nov 18 - Tue, Dec 15

5:00 pm - 9:00 am

STL

SCL

13h 00m

1 stop

10:15 pm - 5:25 pm

SCL

STL

22h 10m

1 stop

$995American Airlines

Wed, Nov 18 - Wed, Nov 25

9:00 am - 5:35 am

STL

SCL

17h 35m

2 stops

11:10 pm - 6:01 pm

SCL

STL

21h 51m

2 stops

$997LATAM Airlines

Wed, Dec 23 - Tue, Dec 29

6:50 pm - 8:50 am

STL

SCL

35h 00m

2 stops

10:45 pm - 4:44 pm

SCL

STL

20h 59m

1 stop

$1,002United Airlines

Wed, Dec 23 - Tue, Dec 29

11:00 am - 7:15 am

STL

SCL

19h 15m

1 stop

8:40 pm - 3:54 pm

SCL

STL

21h 14m

1 stop

$1,007Delta

Wed, Sep 2 - Mon, Sep 7

6:00 am - 4:40 am

STL

SCL

21h 40m

2 stops

8:40 pm - 2:08 pm

SCL

STL

19h 28m

1 stop

$1,007Delta

Wed, Sep 2 - Mon, Sep 7

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American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Sep 9

STL5:00 amLambert-St Louis

25h 00m

1 stop

SCL8:00 amSantiago Arturo Merino Benitez

Nov 16

SCL10:15 pmSantiago Arturo Merino Benitez

26h 32m

1 stop

STL9:47 pmLambert-St Louis

$990

American Airlines

Sep 9

STL10:21 amLambert-St Louis

19h 39m

2 stops

SCL8:00 amSantiago Arturo Merino Benitez

Nov 16

SCL10:15 pmSantiago Arturo Merino Benitez

20h 33m

1 stop

STL3:48 pmLambert-St Louis

$995

American Airlines

Sep 14

STL2:11 pmLambert-St Louis

15h 49m

1 stop

SCL8:00 amSantiago Arturo Merino Benitez

Sep 21

SCL9:30 pmSantiago Arturo Merino Benitez

20h 45m

1 stop

STL4:15 pmLambert-St Louis

$996

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Oct 21

STL2:25 pmLambert-St Louis

22h 00m

3 stops

SCL2:25 pmSantiago Arturo Merino Benitez

Nov 3

SCL4:50 amSantiago Arturo Merino Benitez

20h 09m

2 stops

STL9:59 pmLambert-St Louis

$1,010

LATAM Airlines

Sep 1

STL11:00 amLambert-St Louis

25h 25m

3 stops

SCL1:25 pmSantiago Arturo Merino Benitez

Sep 6

SCL10:30 pmSantiago Arturo Merino Benitez

27h 28m

2 stops

STL11:58 pmLambert-St Louis

$1,012

LATAM Airlines

Sep 1

STL11:00 amLambert-St Louis

19h 15m

1 stop

SCL7:15 amSantiago Arturo Merino Benitez

Sep 6

SCL8:40 pmSantiago Arturo Merino Benitez

14h 40m

1 stop

STL9:20 amLambert-St Louis

$1,027

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/9

5:00 am-8:00 am

1 stop25h 00m

Santiago Arturo Merino Benitez

Mon 11/16

10:15 pm-9:47 pm

1 stop26h 32m

$990

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/18

8:30 am-8:50 am

1 stop21h 20m

Santiago Arturo Merino Benitez

Tue 12/15

10:45 pm-4:44 pm

1 stop20h 59m

$995

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/21

2:25 pm-8:15 am

1 stop15h 50m

Santiago Arturo Merino Benitez

Wed 11/4

11:10 pm-10:51 am

1 stop14h 41m

$995

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/9

12:46 pm-8:00 am

2 stops17h 14m

Santiago Arturo Merino Benitez

Mon 11/16

10:15 pm-2:04 pm

2 stops18h 49m

$995

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/18

1:08 pm-8:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Tue 12/15

10:45 pm-4:44 pm

1 stop20h 59m

$995

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 11/18

5:00 pm-9:00 am

1 stop13h 00m

Santiago Arturo Merino Benitez

Wed 11/25

10:15 pm-5:25 pm

1 stop22h 10m

$995

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 12/23

9:00 am-5:35 am

2 stops17h 35m

Santiago Arturo Merino Benitez

Tue 12/29

11:10 pm-6:01 pm

2 stops21h 51m

$997

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 12/23

6:50 pm-8:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Tue 12/29

10:45 pm-4:44 pm

1 stop20h 59m

$1,002

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

11:00 am-7:15 am

1 stop19h 15m

Santiago Arturo Merino Benitez

Mon 9/7

8:40 pm-3:54 pm

1 stop21h 14m

$1,007

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

6:00 am-4:40 am

2 stops21h 40m

Santiago Arturo Merino Benitez

Mon 9/7

8:40 pm-2:08 pm

1 stop19h 28m

$1,007

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $823. If you don’t want to visit Santiago in March, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $944.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	17h 55m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 17h 55m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

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Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 17h 55m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 40% of the total bookings. Other popular airlines include American Airlines with 34% and LATAM Airlines with 26%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,497 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,845 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,968 reviews	Search LATAM Airlines flights

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Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.