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Cheap flights from St. Louis to Santiago from $391

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 1/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:40 am - 7:50 am
STL
-
SCL
22h 10m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$757United Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
10:00 am - 7:50 am
STL
-
SCL
19h 50m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$758United Airlines
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
12:04 pm - 7:40 am
STL
-
SCL
17h 36m1 stop
LATAM Airlines Logo
10:10 pm - 5:53 pm
SCL
-
STL
21h 43m1 stop
$764LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
5:21 pm - 5:55 pm
STL
-
SCL
22h 34m2 stops
LATAM Airlines Logo
6:30 pm - 5:53 pm
SCL
-
STL
25h 23m2 stops
$766LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
6:59 pm - 2:05 pm
STL
-
SCL
17h 06m2 stops
LATAM Airlines Logo
5:15 am - 11:58 pm
SCL
-
STL
20h 43m2 stops
$767LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
Delta Logo
10:12 am - 6:35 am
STL
-
SCL
18h 23m2 stops
Delta Logo
8:45 pm - 4:16 pm
SCL
-
STL
21h 31m2 stops
$804Delta
Fri, Mar 20 - Mon, Mar 30
LATAM Airlines Logo
5:00 pm - 5:35 pm
STL
-
SCL
21h 35m2 stops
LATAM Airlines Logo
4:20 pm - 11:36 pm
SCL
-
STL
34h 16m2 stops
$844LATAM Airlines
Sun, Feb 15 - Sat, Feb 21
Multiple Airlines Logo
12:14 pm - 6:45 am
STL
-
SCL
64h 31m3 stops
Multiple Airlines Logo
4:35 am - 10:31 am
SCL
-
STL
31h 56m3 stops
$875Multiple Airlines
Wed, Mar 11 - Mon, Mar 23
Multiple Airlines Logo
8:12 pm - 6:45 am
STL
-
SCL
32h 33m3 stops
Multiple Airlines Logo
4:35 am - 10:31 am
SCL
-
STL
31h 56m3 stops
$879Multiple Airlines
Wed, Mar 11 - Mon, Mar 23
Multiple Airlines Logo
4:51 pm - 8:20 pm
STL
-
SCL
49h 29m2 stops
Multiple Airlines Logo
4:35 am - 10:31 am
SCL
-
STL
31h 56m3 stops
$881Multiple Airlines
Wed, Mar 11 - Mon, Mar 23

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets
American Airlines
Apr 13
STL12:03 pmLambert-St Louis
18h 02m
2 stops
SCL7:05 amSantiago Arturo Merino Benitez
Apr 24
SCL8:50 pmSantiago Arturo Merino Benitez
21h 23m
2 stops
STL5:13 pmLambert-St Louis
$884
Find similar
American Airlines
Apr 10
STL10:00 amLambert-St Louis
20h 05m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
Apr 18
SCL8:50 pmSantiago Arturo Merino Benitez
13h 26m
1 stop
STL9:16 amLambert-St Louis
$969
Find similar
American Airlines
Feb 15
STL11:46 amLambert-St Louis
17h 09m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Feb 21
SCL10:00 pmSantiago Arturo Merino Benitez
15h 59m
1 stop
STL10:59 amLambert-St Louis
$1,304
Find similar

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets
LATAM Airlines
Mar 11
STL12:04 pmLambert-St Louis
17h 36m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 23
SCL10:10 pmSantiago Arturo Merino Benitez
21h 43m
1 stop
STL5:53 pmLambert-St Louis
$764
Find similar
LATAM Airlines
Mar 11
STL5:21 pmLambert-St Louis
22h 34m
2 stops
SCL5:55 pmSantiago Arturo Merino Benitez
Mar 23
SCL6:30 pmSantiago Arturo Merino Benitez
25h 23m
2 stops
STL5:53 pmLambert-St Louis
$766
Find similar
LATAM Airlines
Mar 11
STL6:59 pmLambert-St Louis
20h 31m
2 stops
SCL5:30 pmSantiago Arturo Merino Benitez
Mar 23
SCL6:40 amSantiago Arturo Merino Benitez
19h 18m
2 stops
STL11:58 pmLambert-St Louis
$767
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

7:40 am-7:50 am

2 stops22h 10m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

10:00 am-7:50 am

2 stops19h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$758

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:04 pm-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 3/23

10:10 pm-5:53 pm

1 stop21h 43m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

5:21 pm-5:55 pm

2 stops22h 34m

Santiago Arturo Merino Benitez

Mon 3/23

6:30 pm-5:53 pm

2 stops25h 23m

$766

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:59 pm-2:05 pm

2 stops17h 06m

Santiago Arturo Merino Benitez

Mon 3/23

5:15 am-11:58 pm

2 stops20h 43m

$767

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 3/20

10:12 am-6:35 am

2 stops18h 23m

Santiago Arturo Merino Benitez

Mon 3/30

8:45 pm-4:16 pm

2 stops21h 31m

$804

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 2/15

5:00 pm-5:35 pm

2 stops21h 35m

Santiago Arturo Merino Benitez

Sat 2/21

4:20 pm-11:36 pm

2 stops34h 16m

$844

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:14 pm-6:45 am

3 stops64h 31m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-10:31 am

3 stops31h 56m

$875

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

8:12 pm-6:45 am

3 stops32h 33m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-10:31 am

3 stops31h 56m

$879

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

4:51 pm-8:20 pm

2 stops49h 29m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-10:31 am

3 stops31h 56m

$881

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $876. If you don’t want to visit Santiago in March, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $955. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,189.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from St. Louis to Santiago when you can find flight prices for as low as $982. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,074 per ticket.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time

16h 31m

Direct flights

None
The fastest flight from St. Louis to Santiago takes 16h 31m
There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.
Search flight deals

  • How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?

    The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 16h 31m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santiago?

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $689Free CancellationRating
7.2
11,065 reviews
Search American Airlines flights
DeltaPriceFrom $755Free CancellationRating
7.9
8,016 reviews
Search Delta flights
LATAM AirlinesPriceFrom $823Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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