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Cheap flights from St. Louis to Santiago from $379

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Santiago

Cheap round-trip flights

Delta Logo
11:04 am - 6:35 amSTL-SCL
16h 31m2 stops
Delta Logo
6:30 pm - 1:00 pmSCL-STL
21h 30m2 stops
$764Delta
Find Deal
Thu, Nov 27 - Mon, Dec 8
LATAM Airlines Logo
1:55 pm - 6:10 amSTL-SCL
13h 15m1 stop
LATAM Airlines Logo
7:15 am - 11:41 pmSCL-STL
19h 26m3 stops
$768LATAM Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15
LATAM Airlines Logo
11:21 am - 6:45 amSTL-SCL
17h 24m2 stops
LATAM Airlines Logo
5:55 pm - 10:26 amSCL-STL
18h 31m2 stops
$804LATAM Airlines
Find Deal
Wed, Oct 15 - Sat, Oct 25
LATAM Airlines Logo
6:00 am - 6:00 amSTL-SCL
22h 00m2 stops
LATAM Airlines Logo
4:35 am - 9:58 pmSCL-STL
20h 23m2 stops
$808LATAM Airlines
Find Deal
Sat, Nov 1 - Mon, Nov 17
Delta Logo
7:10 am - 7:00 amSTL-SCL
21h 50m1 stop
Delta Logo
1:10 pm - 8:05 amSCL-STL
20h 55m2 stops
$844Delta
Find Deal
Sat, Oct 4 - Sat, Oct 11
United Airlines Logo
6:43 pm - 8:50 amSTL-SCL
36h 07m2 stops
United Airlines Logo
10:45 pm - 12:28 pmSCL-STL
16h 43m2 stops
$848United Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 8
LATAM Airlines Logo
6:01 am - 7:00 amSTL-SCL
22h 59m1 stop
LATAM Airlines Logo
12:10 am - 6:02 pmSCL-STL
19h 52m2 stops
$852LATAM Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
LATAM Airlines Logo
3:15 pm - 2:05 pmSTL-SCL
19h 50m2 stops
LATAM Airlines Logo
12:25 am - 5:57 pmSCL-STL
20h 32m2 stops
$860LATAM Airlines
Find Deal
Thu, Nov 27 - Sun, Dec 7
American Airlines Logo
5:28 am - 7:55 amSTL-SCL
24h 27m1 stop
American Airlines Logo
9:55 pm - 11:56 pmSCL-STL
28h 01m1 stop
$866American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 11
American Airlines Logo
5:03 pm - 9:05 amSTL-SCL
14h 02m1 stop
American Airlines Logo
10:15 pm - 9:52 amSCL-STL
13h 37m1 stop
$944American Airlines
Find Deal
Mon, Mar 9 - Fri, Mar 20

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets
American Airlines
Oct 4
STL5:28 amLambert-St Louis
24h 27m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Oct 11
SCL9:55 pmSantiago Arturo Merino Benitez
28h 01m
1 stop
STL11:56 pmLambert-St Louis
$866
Find similar
American Airlines
Mar 9
STL5:03 pmLambert-St Louis
14h 02m
1 stop
SCL9:05 amSantiago Arturo Merino Benitez
Mar 20
SCL10:15 pmSantiago Arturo Merino Benitez
13h 37m
1 stop
STL9:52 amLambert-St Louis
$944
Find similar
American Airlines
Dec 25
STL9:36 amLambert-St Louis
19h 09m
1 stop
SCL7:45 amSantiago Arturo Merino Benitez
Jan 11
SCL10:15 pmSantiago Arturo Merino Benitez
20h 24m
1 stop
STL3:39 pmLambert-St Louis
$1,004
Find similar

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets
LATAM Airlines
Dec 11
STL1:55 pmLambert-St Louis
13h 15m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Dec 15
SCL7:15 amSantiago Arturo Merino Benitez
19h 26m
3 stops
STL11:41 pmLambert-St Louis
$768
Find similar
LATAM Airlines
Oct 15
STL11:21 amLambert-St Louis
17h 24m
2 stops
SCL6:45 amSantiago Arturo Merino Benitez
Oct 25
SCL5:55 pmSantiago Arturo Merino Benitez
18h 31m
2 stops
STL10:26 amLambert-St Louis
$804
Find similar
LATAM Airlines
Nov 1
STL6:00 amLambert-St Louis
22h 00m
2 stops
SCL6:00 amSantiago Arturo Merino Benitez
Nov 17
SCL4:35 amSantiago Arturo Merino Benitez
20h 23m
2 stops
STL9:58 pmLambert-St Louis
$808
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 19, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

11:04 am-6:35 am

2 stops16h 31m

Santiago Arturo Merino Benitez

Mon 12/8

6:30 pm-1:00 pm

2 stops21h 30m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

1:55 pm-6:10 am

1 stop13h 15m

Santiago Arturo Merino Benitez

Mon 12/15

7:15 am-11:41 pm

3 stops19h 26m

$768

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/15

11:21 am-6:45 am

2 stops17h 24m

Santiago Arturo Merino Benitez

Sat 10/25

5:55 pm-10:26 am

2 stops18h 31m

$804

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 11/1

6:00 am-6:00 am

2 stops22h 00m

Santiago Arturo Merino Benitez

Mon 11/17

4:35 am-9:58 pm

2 stops20h 23m

$808

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 10/4

7:10 am-7:00 am

1 stop21h 50m

Santiago Arturo Merino Benitez

Sat 10/11

1:10 pm-8:05 am

2 stops20h 55m

$844

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 11/1

6:43 pm-8:50 am

2 stops36h 07m

Santiago Arturo Merino Benitez

Sat 11/8

10:45 pm-12:28 pm

2 stops16h 43m

$848

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 10/4

6:01 am-7:00 am

1 stop22h 59m

Santiago Arturo Merino Benitez

Fri 10/10

12:10 am-6:02 pm

2 stops19h 52m

$852

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

3:15 pm-2:05 pm

2 stops19h 50m

Santiago Arturo Merino Benitez

Sun 12/7

12:25 am-5:57 pm

2 stops20h 32m

$860

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 10/4

5:28 am-7:55 am

1 stop24h 27m

Santiago Arturo Merino Benitez

Sat 10/11

9:55 pm-11:56 pm

1 stop28h 01m

$866

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 3/9

5:03 pm-9:05 am

1 stop14h 02m

Santiago Arturo Merino Benitez

Fri 3/20

10:15 pm-9:52 am

1 stop13h 37m

$944

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $772. If you don’t want to visit Santiago in October, then you should wait until September to fly from St. Louis, when ticket prices are also cheap, with an average price of $843.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $955. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,189.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from St. Louis to Santiago when you can find flight prices for as low as $982. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,074 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $971 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from St. Louis for as low as $902 on momondo.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Direct flights

None
There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.
Search flight deals

  • How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?

    The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 25m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santiago?

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $762Free CancellationRating
7.5
1,849 reviews
Search LATAM Airlines flights
DeltaPriceFrom $803Free CancellationRating
7.9
7,964 reviews
Search Delta flights
American AirlinesPriceFrom $823Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $883Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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