Cheap flights from St. Louis to Santiago from $413

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
6:00 am - 5:35 am
STL
-
SCL
21h 35m
2 stops
LATAM Airlines Logo
4:35 am - 11:58 pm
SCL
-
STL
21h 23m
2 stops
$830LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
6:00 am - 7:50 am
STL
-
SCL
23h 50m
1 stop
United Airlines Logo
9:45 pm - 6:00 pm
SCL
-
STL
22h 15m
2 stops
$851United Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
4:47 pm - 7:50 am
STL
-
SCL
13h 03m
1 stop
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m
1 stop
$853United Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
6:00 am - 7:50 am
STL
-
SCL
23h 50m
1 stop
United Airlines Logo
9:45 pm - 10:59 pm
SCL
-
STL
27h 14m
2 stops
$855United Airlines
Wed, Mar 11 - Mon, Mar 23
Delta Logo
10:12 am - 7:40 am
STL
-
SCL
19h 28m
1 stop
Delta Logo
6:30 pm - 11:09 am
SCL
-
STL
18h 39m
2 stops
$858Delta
Wed, Mar 11 - Mon, Mar 23
American Airlines Logo
7:00 am - 7:00 am
STL
-
SCL
22h 00m
1 stop
American Airlines Logo
9:20 pm - 10:32 am
SCL
-
STL
15h 12m
1 stop
$860American Airlines
Wed, Mar 11 - Mon, Mar 23
Delta Logo
6:00 am - 5:35 am
STL
-
SCL
21h 35m
2 stops
Delta Logo
11:25 pm - 5:53 pm
SCL
-
STL
20h 28m
2 stops
$863Delta
Wed, Mar 11 - Mon, Mar 23
American Airlines Logo
5:15 am - 9:05 am
STL
-
SCL
25h 50m
1 stop
American Airlines Logo
9:20 pm - 11:58 pm
SCL
-
STL
28h 38m
1 stop
$864American Airlines
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
1:27 pm - 6:55 am
STL
-
SCL
16h 28m
2 stops
LATAM Airlines Logo
11:05 pm - 6:02 pm
SCL
-
STL
19h 57m
2 stops
$882LATAM Airlines
Thu, May 21 - Sat, May 30
LATAM Airlines Logo
12:04 pm - 7:40 am
STL
-
SCL
17h 36m
1 stop
LATAM Airlines Logo
11:00 pm - 5:53 pm
SCL
-
STL
20h 53m
2 stops
$893LATAM Airlines
Fri, Mar 20 - Mon, Mar 30

Delta flights from St. Louis to Santiago

Our best Delta deals on St. Louis to Santiago flight tickets
Delta
Mar 11
STL10:12 amLambert-St Louis
19h 28m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 23
SCL6:30 pmSantiago Arturo Merino Benitez
18h 39m
2 stops
STL11:09 amLambert-St Louis
$858
Delta
Mar 11
STL6:00 amLambert-St Louis
21h 35m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 23
SCL11:25 pmSantiago Arturo Merino Benitez
20h 28m
2 stops
STL5:53 pmLambert-St Louis
$863
Delta
Mar 28
STL10:07 amLambert-St Louis
20h 08m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Apr 4
SCL11:00 pmSantiago Arturo Merino Benitez
24h 06m
2 stops
STL9:06 pmLambert-St Louis
$943

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets
American Airlines
Mar 11
STL7:00 amLambert-St Louis
22h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Mar 23
SCL9:20 pmSantiago Arturo Merino Benitez
15h 12m
1 stop
STL10:32 amLambert-St Louis
$860
American Airlines
Mar 11
STL5:15 amLambert-St Louis
25h 50m
1 stop
SCL9:05 amSantiago Arturo Merino Benitez
Mar 23
SCL9:20 pmSantiago Arturo Merino Benitez
28h 38m
1 stop
STL11:58 pmLambert-St Louis
$864
American Airlines
Mar 28
STL5:15 amLambert-St Louis
24h 45m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Apr 4
SCL9:25 pmSantiago Arturo Merino Benitez
15h 07m
1 stop
STL10:32 amLambert-St Louis
$950

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-5:35 am

2 stops21h 35m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-11:58 pm

2 stops21h 23m

$830

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-6:00 pm

2 stops22h 15m

$851

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

4:47 pm-7:50 am

1 stop13h 03m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$853

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-10:59 pm

2 stops27h 14m

$855

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

10:12 am-7:40 am

1 stop19h 28m

Santiago Arturo Merino Benitez

Mon 3/23

6:30 pm-11:09 am

2 stops18h 39m

$858

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

7:00 am-7:00 am

1 stop22h 00m

Santiago Arturo Merino Benitez

Mon 3/23

9:20 pm-10:32 am

1 stop15h 12m

$860

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-5:35 am

2 stops21h 35m

Santiago Arturo Merino Benitez

Mon 3/23

11:25 pm-5:53 pm

2 stops20h 28m

$863

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

5:15 am-9:05 am

1 stop25h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:20 pm-11:58 pm

1 stop28h 38m

$864

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/21

1:27 pm-6:55 am

2 stops16h 28m

Santiago Arturo Merino Benitez

Sat 5/30

11:05 pm-6:02 pm

2 stops19h 57m

$882

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 3/20

12:04 pm-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 3/30

11:00 pm-5:53 pm

2 stops20h 53m

$893

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, July is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $883. If you don’t want to visit Santiago in July, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $903.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time

19h 35m

Direct flights

None
The fastest flight from St. Louis to Santiago takes 19h 35m
There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.
  • How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?

    The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 19h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santiago?

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $689Free CancellationRating
7.2
11,271 reviews
Search American Airlines flights
DeltaPriceFrom $755Free CancellationRating
7.9
8,180 reviews
Search Delta flights
LATAM AirlinesPriceFrom $801Free CancellationRating
7.5
1,921 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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1 adult
Sat 3/14
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