Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

LATAM Airlines and American Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of April 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$361 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $1,168 to $1,088. The lowest price recently found on this route was $920.

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Find the cheapest flights from St. Louis to Santiago

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9:00 am - 5:35 am

STL

SCL

18h 35m

2 stops

10:55 pm - 5:06 pm

SCL

STL

20h 11m

1 stop

$920LATAM Airlines

Tue, Sep 15 - Tue, Oct 13

2:12 pm - 8:50 am

STL

SCL

16h 38m

1 stop

9:30 pm - 5:23 pm

SCL

STL

21h 53m

1 stop

$925American Airlines

Tue, Sep 15 - Tue, Oct 13

1:39 pm - 6:55 am

STL

SCL

16h 16m

2 stops

8:40 pm - 12:34 pm

SCL

STL

16h 54m

1 stop

$1,076LATAM Airlines

Mon, Jun 15 - Wed, Jun 24

11:04 am - 7:05 am

STL

SCL

19h 01m

1 stop

9:00 pm - 10:35 am

SCL

STL

14h 35m

1 stop

$1,085American Airlines

Mon, Jun 15 - Wed, Jun 24

10:51 am - 10:49 am

STL

SCL

22h 58m

3 stops

4:50 pm - 12:34 pm

SCL

STL

20h 44m

2 stops

$1,087LATAM Airlines

Mon, Jun 15 - Wed, Jun 24

1:39 pm - 5:35 am

STL

SCL

14h 56m

2 stops

8:40 pm - 9:06 am

SCL

STL

13h 26m

1 stop

$1,106LATAM Airlines

Wed, Jul 1 - Fri, Jul 31

1:39 pm - 5:35 am

STL

SCL

14h 56m

2 stops

5:40 am - 11:40 pm

SCL

STL

19h 00m

2 stops

$1,108LATAM Airlines

Fri, Jul 3 - Sat, Jul 11

10:51 am - 1:25 pm

STL

SCL

25h 34m

3 stops

4:10 am - 11:53 pm

SCL

STL

20h 43m

2 stops

$1,122LATAM Airlines

Wed, Jul 1 - Fri, Jul 31

5:07 pm - 7:15 am

STL

SCL

13h 08m

1 stop

8:40 pm - 9:06 am

SCL

STL

13h 26m

1 stop

$1,125LATAM Airlines

Wed, Jul 1 - Fri, Jul 31

1:39 pm - 1:25 pm

STL

SCL

22h 46m

3 stops

8:30 am - 9:46 am

SCL

STL

26h 16m

3 stops

$1,131LATAM Airlines

Mon, Jun 15 - Wed, Jun 24

Avianca flights from St. Louis to Santiago

Our best Avianca deals on St. Louis to Santiago flight tickets

Avianca

May 5

STL8:45 amLambert-St Louis

19h 00m

2 stops

SCL4:45 amSantiago Arturo Merino Benitez

May 7

SCL6:40 amSantiago Arturo Merino Benitez

52h 48m

2 stops

STL10:28 amLambert-St Louis

$1,372

Avianca

May 5

STL8:45 amLambert-St Louis

28h 30m

2 stops

SCL2:15 pmSantiago Arturo Merino Benitez

May 6

SCL12:30 amSantiago Arturo Merino Benitez

33h 09m

2 stops

STL8:39 amLambert-St Louis

$1,396

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Sep 15

STL9:00 amLambert-St Louis

18h 35m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Oct 13

SCL10:55 pmSantiago Arturo Merino Benitez

20h 11m

1 stop

STL5:06 pmLambert-St Louis

$920

LATAM Airlines

Jun 15

STL1:39 pmLambert-St Louis

16h 16m

2 stops

SCL6:55 amSantiago Arturo Merino Benitez

Jun 24

SCL8:40 pmSantiago Arturo Merino Benitez

16h 54m

1 stop

STL12:34 pmLambert-St Louis

$1,076

LATAM Airlines

Jun 15

STL10:51 amLambert-St Louis

22h 58m

3 stops

SCL10:49 amSantiago Arturo Merino Benitez

Jun 24

SCL4:50 pmSantiago Arturo Merino Benitez

20h 44m

2 stops

STL12:34 pmLambert-St Louis

$1,087

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/15

9:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Tue 10/13

10:55 pm-5:06 pm

1 stop20h 11m

$920

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/15

2:12 pm-8:50 am

1 stop16h 38m

Santiago Arturo Merino Benitez

Tue 10/13

9:30 pm-5:23 pm

1 stop21h 53m

$925

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/15

1:39 pm-6:55 am

2 stops16h 16m

Santiago Arturo Merino Benitez

Wed 6/24

8:40 pm-12:34 pm

1 stop16h 54m

$1,076

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/15

11:04 am-7:05 am

1 stop19h 01m

Santiago Arturo Merino Benitez

Wed 6/24

9:00 pm-10:35 am

1 stop14h 35m

$1,085

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/15

10:51 am-10:49 am

3 stops22h 58m

Santiago Arturo Merino Benitez

Wed 6/24

4:50 pm-12:34 pm

2 stops20h 44m

$1,087

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 7/1

1:39 pm-5:35 am

2 stops14h 56m

Santiago Arturo Merino Benitez

Fri 7/31

8:40 pm-9:06 am

1 stop13h 26m

$1,106

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

1:39 pm-5:35 am

2 stops14h 56m

Santiago Arturo Merino Benitez

Sat 7/11

5:40 am-11:40 pm

2 stops19h 00m

$1,108

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 7/1

10:51 am-1:25 pm

3 stops25h 34m

Santiago Arturo Merino Benitez

Fri 7/31

4:10 am-11:53 pm

2 stops20h 43m

$1,122

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 7/1

5:07 pm-7:15 am

1 stop13h 08m

Santiago Arturo Merino Benitez

Fri 7/31

8:40 pm-9:06 am

1 stop13h 26m

$1,125

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 6/15

1:39 pm-1:25 pm

3 stops22h 46m

Santiago Arturo Merino Benitez

Wed 6/24

8:30 am-9:46 am

3 stops26h 16m

$1,131

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $793. If you don’t want to visit Santiago in March, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	12h 51m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 12h 51m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

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Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 51m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of April 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 42% of the total bookings. Other popular airlines include American Airlines with 30% and LATAM Airlines with 28%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.9 8,467 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,680 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,913 reviews	Search LATAM Airlines flights

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Santa Cruz

Valle Nevado

Pichilemu

San Fernando

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.