Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$1,016 Cheap Flights from St. Louis to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

12:20 pm - 9:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 40m1 stop Miami

10:15 pm - 5:27 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

21h 12m1 stop Miami

$1,016American Airlines

Wed, Mar 3 - Mon, Mar 15

9:41 am - 7:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

19h 04m1 stop Dallas/Fort Worth

11:45 pm - 2:04 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

17h 19m1 stop Dallas/Fort Worth

$1,016American Airlines

Tue, Jan 26 - Fri, Feb 12

6:15 am - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 35m1 stop Houston George Bush Intcntl

10:45 pm - 4:44 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

20h 59m1 stop Houston George Bush Intcntl

$1,016United Airlines

Mon, Feb 15 - Tue, Mar 2

5:29 am - 7:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 16m1 stop Dallas/Fort Worth

11:45 pm - 2:55 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 10m1 stop Dallas/Fort Worth

$1,016American Airlines

Thu, Jan 14 - Tue, Jan 26

6:15 am - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 35m1 stop Houston George Bush Intcntl

10:45 pm - 3:04 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 19m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,020United Airlines

Mon, Feb 15 - Tue, Mar 2

10:05 am - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

19h 45m1 stop Houston George Bush Intcntl

10:45 pm - 3:46 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

20h 01m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,020United Airlines

Mon, Feb 15 - Tue, Mar 2

6:00 am - 7:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

22h 40m1 stop Atlanta Hartsfield-Jackson

9:50 pm - 8:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 22m1 stop Atlanta Hartsfield-Jackson

$1,065LATAM Airlines

Wed, Jan 6 - Sat, Jan 23

6:00 am - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

21h 40m1 stop Atlanta Hartsfield-Jackson

9:50 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

15h 58m1 stop Atlanta Hartsfield-Jackson

$1,066Delta

Mon, Dec 28 - Fri, Jan 15

3:48 pm - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

11h 52m1 stop Atlanta Hartsfield-Jackson

8:13 am - 11:39 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 26m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,066Delta

Mon, Dec 28 - Fri, Jan 15

3:40 pm - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

20h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

7:40 am - 11:39 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 59m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,066LATAM Airlines

Sat, Feb 20 - Sat, Mar 6

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United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Feb 15

STL6:15 amLambert-St Louis

23h 35m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Mar 2

SCL10:45 pmSantiago Arturo Merino Benitez

13h 57m

1 stop

STL9:42 amLambert-St Louis

$1,016

United Airlines

Feb 15

STL10:05 amLambert-St Louis

19h 45m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Mar 2

SCL10:45 pmSantiago Arturo Merino Benitez

20h 01m

2 stops

STL3:46 pmLambert-St Louis

$1,020

United Airlines

Dec 6

STL6:55 pmLambert-St Louis

34h 55m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Dec 20

SCL10:45 pmSantiago Arturo Merino Benitez

22h 33m

2 stops

STL6:18 pmLambert-St Louis

$1,056

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Apr 3

STL11:19 amLambert-St Louis

18h 46m

1 stop

SCL8:05 amSantiago Arturo Merino Benitez

Apr 17

SCL8:35 pmSantiago Arturo Merino Benitez

13h 45m

1 stop

STL9:20 amLambert-St Louis

$1,038

American Airlines

Apr 3

STL11:41 amLambert-St Louis

18h 24m

2 stops

SCL8:05 amSantiago Arturo Merino Benitez

Apr 17

SCL8:35 pmSantiago Arturo Merino Benitez

13h 45m

1 stop

STL9:20 amLambert-St Louis

$1,042

American Airlines

Dec 6

STL5:50 amLambert-St Louis

23h 25m

1 stop

SCL8:15 amSantiago Arturo Merino Benitez

Dec 20

SCL10:25 pmSantiago Arturo Merino Benitez

22h 20m

1 stop

STL5:45 pmLambert-St Louis

$1,065

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 3/3

12:20 pm-9:00 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Mon 3/15

10:15 pm-5:27 pm

1 stop21h 12m

$1,016

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 1/26

9:41 am-7:45 am

1 stop19h 04m

Santiago Arturo Merino Benitez

Fri 2/12

11:45 pm-2:04 pm

1 stop17h 19m

$1,016

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

6:15 am-8:50 am

1 stop23h 35m

Santiago Arturo Merino Benitez

Tue 3/2

10:45 pm-4:44 pm

1 stop20h 59m

$1,016

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 1/14

5:29 am-7:45 am

1 stop23h 16m

Santiago Arturo Merino Benitez

Tue 1/26

11:45 pm-2:55 pm

1 stop18h 10m

$1,016

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

6:15 am-8:50 am

1 stop23h 35m

Santiago Arturo Merino Benitez

Tue 3/2

10:45 pm-3:04 pm

2 stops19h 19m

$1,020

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

10:05 am-8:50 am

1 stop19h 45m

Santiago Arturo Merino Benitez

Tue 3/2

10:45 pm-3:46 pm

2 stops20h 01m

$1,020

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 1/6

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

Sat 1/23

9:50 pm-8:12 am

1 stop13h 22m

$1,065

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 12/28

6:00 am-6:40 am

1 stop21h 40m

Santiago Arturo Merino Benitez

Fri 1/15

9:50 pm-10:48 am

1 stop15h 58m

$1,066

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 12/28

3:48 pm-6:40 am

1 stop11h 52m

Santiago Arturo Merino Benitez

Fri 1/15

8:13 am-11:39 pm

2 stops18h 26m

$1,066

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 2/20

3:40 pm-3:00 pm

2 stops20h 20m

Santiago Arturo Merino Benitez

Sat 3/6

7:40 am-11:39 pm

2 stops18h 59m

$1,066

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $755. If you don’t want to visit Santiago in March, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $944.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$1,016
Fastest flight time	18h 46m
Direct flights	None

The best flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $1,016

The fastest flight from St. Louis to Santiago takes 18h 46m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 18h 46m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 46% of the total bookings. Other popular airlines include American Airlines with 32% and LATAM Airlines with 22%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,628 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.0 12,125 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,975 reviews	Search LATAM Airlines flights

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San Fernando

Valle Nevado

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.