Cheap flights from St. Louis to Santiago from $485
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
Discover deals from 900+ travel sites with momondo.
Find the cheapest flights from St. Louis to Santiago
Cheap round-trip flights
Cheap one-way flights
Cheap last minute flights
Save money when you book flights with momondo
Big names and deals
Big names and deals
Search 100s of travel sites to compare prices.Filter for what you want
Filter for what you want
Free Wi-Fi? Stopover? Instantly customize your results.Trusted and free
Trusted and free
We’re completely free to use - no hidden charges or fees.Price Alerts
Price Alerts
Not ready to book? to track prices.LATAM Airlines flights from St. Louis to Santiago
Our best LATAM Airlines deals on St. Louis to Santiago flight tickets
Delta flights from St. Louis to Santiago
Our best Delta deals on St. Louis to Santiago flight tickets
momondo Fare Finder
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 3/3
9:00 am-6:40 am
1 stop18h 40m
Santiago Arturo Merino Benitez
Mon 3/15
11:10 pm-2:43 pm
2 stops17h 33m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 3/3
6:00 am-5:35 am
2 stops20h 35m
Santiago Arturo Merino Benitez
Mon 3/15
11:10 pm-2:43 pm
2 stops17h 33m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 3/3
12:20 pm-9:00 am
1 stop17h 40m
Santiago Arturo Merino Benitez
Mon 3/15
10:15 pm-5:27 pm
1 stop21h 12m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 2/15
6:15 am-8:50 am
1 stop23h 35m
Santiago Arturo Merino Benitez
Tue 3/2
10:45 pm-9:42 am
1 stop13h 57m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 2/15
3:40 pm-5:40 pm
2 stops23h 00m
Santiago Arturo Merino Benitez
Tue 3/2
8:25 pm-10:48 am
2 stops17h 23m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Wed 3/3
11:56 am-9:00 am
2 stops18h 04m
Santiago Arturo Merino Benitez
Mon 3/15
11:45 pm-6:13 pm
1 stop20h 28m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Mon 2/15
5:00 am-8:50 am
2 stops24h 50m
Santiago Arturo Merino Benitez
Tue 3/2
10:45 pm-3:04 pm
2 stops19h 19m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 2/20
3:40 pm-3:00 pm
2 stops20h 20m
Santiago Arturo Merino Benitez
Sat 3/6
9:50 pm-2:43 pm
1 stop19h 53m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sat 2/20
3:40 pm-3:00 pm
2 stops20h 20m
Santiago Arturo Merino Benitez
Sat 3/6
9:50 pm-2:43 pm
1 stop19h 53m
St. LouisSantiago
STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez
STLSCL
Lambert-St Louis
Sun 1/3
9:15 am-8:00 am
2 stops19h 45m
Santiago Arturo Merino Benitez
Tue 1/26
11:45 pm-10:52 am
1 stop14h 07m
See travel insights to Santiago from
How to get the cheapest flight ticket from St. Louis to Santiago
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
Which airport is the most popular layover for flights between St. Louis and Santiago?
Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.
Which layover airport offers the lowest fares from St. Louis to Santiago?
Flights via Miami (MIA) offer the lowest average round-trip price of $898.
Which layover airport has the shortest travel time from St. Louis to Santiago?
Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.
Which layover airport has the shortest connection time from St. Louis to Santiago?
Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.
When to book flights from St. Louis to Santiago
Cheap St. Louis to Santiago (STL to SCL) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago
Frequently asked questions about flying from St. Louis to Santiago
How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 14h 50m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 46% of the total bookings. Other popular airlines include American Airlines with 32% and LATAM Airlines with 22%.
Best airlines flying from St. Louis to Santiago
Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $611 | Free Cancellation | Rating 7.8 8,645 reviews | |||
| PriceFrom $689 | Free Cancellation | Rating 7.0 12,145 reviews | |||
| PriceFrom $792 | Free Cancellation | Rating 7.4 1,975 reviews |
Traveling to a place near Santiago?
Book flights to Santiago if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from St. Louis to Santiago?
Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.
Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?
Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.
How can momondo help me find flights from St. Louis to Santiago?
momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.
I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?
If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.