Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines is the most popular carrier operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of July 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$633 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently typical for flights on this route. Typical prices usually range from $811 to $1,176. The lowest price recently found on this route was $947.

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:35 am - 6:25 am

STL

SCL

17h 50m

1 stop

9:50 pm - 10:45 am

SCL

STL

14h 55m

1 stop

$947American Airlines

Tue, Sep 1 - Sun, Sep 6

11:35 am - 6:25 am

STL

SCL

17h 50m

1 stop

9:30 pm - 2:44 pm

SCL

STL

19h 14m

2 stops

$952American Airlines

Tue, Sep 1 - Fri, Sep 18

7:20 pm - 5:00 pm

STL

SCL

19h 40m

2 stops

11:48 pm - 4:23 pm

SCL

STL

19h 35m

2 stops

$957LATAM Airlines

Wed, Oct 28 - Sun, Nov 1

12:52 pm - 1:25 pm

STL

SCL

23h 33m

3 stops

11:05 pm - 11:42 pm

SCL

STL

26h 37m

2 stops

$962LATAM Airlines

Wed, Sep 2 - Mon, Sep 7

1:08 pm - 7:50 am

STL

SCL

16h 42m

2 stops

10:45 pm - 10:05 am

SCL

STL

14h 20m

1 stop

$977United Airlines

Wed, Oct 28 - Sun, Nov 1

5:23 pm - 7:45 pm

STL

SCL

25h 22m

2 stops

8:30 am - 9:34 am

SCL

STL

27h 04m

3 stops

$986LATAM Airlines

Wed, Sep 2 - Mon, Sep 7

12:52 pm - 1:25 pm

STL

SCL

23h 33m

3 stops

7:50 am - 11:42 pm

SCL

STL

17h 52m

2 stops

$992LATAM Airlines

Tue, Sep 1 - Fri, Sep 18

11:35 am - 7:05 am

STL

SCL

18h 30m

1 stop

8:50 pm - 10:45 am

SCL

STL

14h 55m

1 stop

$1,007American Airlines

Sat, Aug 15 - Sat, Aug 22

12:45 pm - 7:05 am

STL

SCL

17h 20m

2 stops

8:50 pm - 10:45 am

SCL

STL

14h 55m

1 stop

$1,012American Airlines

Sat, Aug 15 - Sat, Aug 22

6:00 am - 6:55 am

STL

SCL

23h 55m

2 stops

8:30 am - 11:46 am

SCL

STL

29h 16m

3 stops

$1,016LATAM Airlines

Tue, Sep 1 - Sun, Sep 6

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LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Oct 28

STL7:20 pmLambert-St Louis

19h 40m

2 stops

SCL5:00 pmSantiago Arturo Merino Benitez

Nov 1

SCL11:48 pmSantiago Arturo Merino Benitez

19h 35m

2 stops

STL4:23 pmLambert-St Louis

$957

LATAM Airlines

Sep 2

STL12:52 pmLambert-St Louis

23h 33m

3 stops

SCL1:25 pmSantiago Arturo Merino Benitez

Sep 7

SCL11:05 pmSantiago Arturo Merino Benitez

26h 37m

2 stops

STL11:42 pmLambert-St Louis

$962

LATAM Airlines

Sep 2

STL5:23 pmLambert-St Louis

25h 22m

2 stops

SCL7:45 pmSantiago Arturo Merino Benitez

Sep 7

SCL8:30 amSantiago Arturo Merino Benitez

27h 04m

3 stops

STL9:34 amLambert-St Louis

$986

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Sep 1

STL11:35 amLambert-St Louis

17h 50m

1 stop

SCL6:25 amSantiago Arturo Merino Benitez

Sep 6

SCL9:50 pmSantiago Arturo Merino Benitez

14h 55m

1 stop

STL10:45 amLambert-St Louis

$947

American Airlines

Sep 1

STL11:35 amLambert-St Louis

17h 50m

1 stop

SCL6:25 amSantiago Arturo Merino Benitez

Sep 18

SCL9:30 pmSantiago Arturo Merino Benitez

19h 14m

2 stops

STL2:44 pmLambert-St Louis

$952

American Airlines

Nov 30

STL5:21 amLambert-St Louis

24h 39m

1 stop

SCL9:00 amSantiago Arturo Merino Benitez

Dec 13

SCL11:45 pmSantiago Arturo Merino Benitez

22h 42m

1 stop

STL7:27 pmLambert-St Louis

$8,145

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

11:35 am-6:25 am

1 stop17h 50m

Santiago Arturo Merino Benitez

Sun 9/6

9:50 pm-10:45 am

1 stop14h 55m

$947

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

11:35 am-6:25 am

1 stop17h 50m

Santiago Arturo Merino Benitez

Fri 9/18

9:30 pm-2:44 pm

2 stops19h 14m

$952

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/28

7:20 pm-5:00 pm

2 stops19h 40m

Santiago Arturo Merino Benitez

Sun 11/1

11:48 pm-4:23 pm

2 stops19h 35m

$957

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

12:52 pm-1:25 pm

3 stops23h 33m

Santiago Arturo Merino Benitez

Mon 9/7

11:05 pm-11:42 pm

2 stops26h 37m

$962

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 10/28

1:08 pm-7:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Sun 11/1

10:45 pm-10:05 am

1 stop14h 20m

$977

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

5:23 pm-7:45 pm

2 stops25h 22m

Santiago Arturo Merino Benitez

Mon 9/7

8:30 am-9:34 am

3 stops27h 04m

$986

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

12:52 pm-1:25 pm

3 stops23h 33m

Santiago Arturo Merino Benitez

Fri 9/18

7:50 am-11:42 pm

2 stops17h 52m

$992

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 8/15

11:35 am-7:05 am

1 stop18h 30m

Santiago Arturo Merino Benitez

Sat 8/22

8:50 pm-10:45 am

1 stop14h 55m

$1,007

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 8/15

12:45 pm-7:05 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Sat 8/22

8:50 pm-10:45 am

1 stop14h 55m

$1,012

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

6:00 am-6:55 am

2 stops23h 55m

Santiago Arturo Merino Benitez

Sun 9/6

8:30 am-11:46 am

3 stops29h 16m

$1,016

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $823. If you don’t want to visit Santiago in March, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $944.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	13h 33m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 13h 33m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 13h 33m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of July 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 43% of the total bookings. Other popular airlines include American Airlines with 31% and LATAM Airlines with 26%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,452 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,782 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,949 reviews	Search LATAM Airlines flights

Viña del Mar

Valparaíso

Santa Cruz

Valle Nevado

San Fernando

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.