Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines and Delta are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of April 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$402 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $1,071 to $992. The lowest price recently found on this route was $920.

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Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

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9:00 am - 5:35 am

STL

SCL

18h 35m

2 stops

10:55 pm - 5:06 pm

SCL

STL

20h 11m

1 stop

$920LATAM Airlines

Tue, Oct 6 - Tue, Oct 20

6:08 pm - 7:50 am

STL

SCL

11h 42m

1 stop

9:30 pm - 5:23 pm

SCL

STL

21h 53m

1 stop

$925American Airlines

Tue, Oct 6 - Tue, Oct 20

1:19 pm - 7:05 am

STL

SCL

16h 46m

2 stops

9:00 pm - 10:35 am

SCL

STL

14h 35m

1 stop

$960American Airlines

Thu, May 28 - Wed, Jun 10

5:15 am - 7:05 am

STL

SCL

24h 50m

1 stop

9:00 pm - 10:35 am

SCL

STL

14h 35m

1 stop

$966American Airlines

Thu, May 28 - Wed, Jun 10

6:00 am - 5:35 am

STL

SCL

21h 35m

2 stops

12:00 am - 6:01 pm

SCL

STL

20h 01m

2 stops

$971LATAM Airlines

Tue, Oct 6 - Tue, Oct 20

1:19 pm - 7:05 am

STL

SCL

16h 46m

2 stops

9:00 pm - 4:58 pm

SCL

STL

20h 58m

2 stops

$997American Airlines

Thu, May 28 - Wed, Jun 10

5:30 pm - 1:25 pm

STL

SCL

17h 55m

3 stops

7:45 pm - 10:48 am

SCL

STL

17h 03m

2 stops

$1,024LATAM Airlines

Tue, Oct 6 - Tue, Oct 20

10:49 am - 10:49 am

STL

SCL

23h 00m

3 stops

4:10 am - 11:56 pm

SCL

STL

20h 46m

2 stops

$1,032LATAM Airlines

Thu, May 28 - Wed, Jun 10

10:51 am - 6:00 am

STL

SCL

18h 09m

2 stops

8:40 pm - 9:46 am

SCL

STL

14h 06m

1 stop

$1,037LATAM Airlines

Tue, Jun 16 - Tue, Jun 30

5:20 pm - 7:15 am

STL

SCL

12h 55m

1 stop

11:05 pm - 5:56 pm

SCL

STL

19h 51m

2 stops

$1,041LATAM Airlines

Fri, May 22 - Sat, May 30

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Oct 6

STL9:00 amLambert-St Louis

18h 35m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Oct 20

SCL10:55 pmSantiago Arturo Merino Benitez

20h 11m

1 stop

STL5:06 pmLambert-St Louis

$920

LATAM Airlines

Oct 6

STL6:00 amLambert-St Louis

21h 35m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Oct 20

SCL12:00 amSantiago Arturo Merino Benitez

20h 01m

2 stops

STL6:01 pmLambert-St Louis

$971

LATAM Airlines

Oct 6

STL5:30 pmLambert-St Louis

17h 55m

3 stops

SCL1:25 pmSantiago Arturo Merino Benitez

Oct 20

SCL7:45 pmSantiago Arturo Merino Benitez

17h 03m

2 stops

STL10:48 amLambert-St Louis

$1,024

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Oct 6

STL6:08 pmLambert-St Louis

11h 42m

1 stop

SCL7:50 amSantiago Arturo Merino Benitez

Oct 20

SCL9:30 pmSantiago Arturo Merino Benitez

21h 53m

1 stop

STL5:23 pmLambert-St Louis

$925

American Airlines

May 28

STL1:19 pmLambert-St Louis

16h 46m

2 stops

SCL7:05 amSantiago Arturo Merino Benitez

Jun 10

SCL9:00 pmSantiago Arturo Merino Benitez

14h 35m

1 stop

STL10:35 amLambert-St Louis

$960

American Airlines

May 28

STL5:15 amLambert-St Louis

24h 50m

1 stop

SCL7:05 amSantiago Arturo Merino Benitez

Jun 10

SCL9:00 pmSantiago Arturo Merino Benitez

14h 35m

1 stop

STL10:35 amLambert-St Louis

$966

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/6

9:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Tue 10/20

10:55 pm-5:06 pm

1 stop20h 11m

$920

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/6

6:08 pm-7:50 am

1 stop11h 42m

Santiago Arturo Merino Benitez

Tue 10/20

9:30 pm-5:23 pm

1 stop21h 53m

$925

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/28

1:19 pm-7:05 am

2 stops16h 46m

Santiago Arturo Merino Benitez

Wed 6/10

9:00 pm-10:35 am

1 stop14h 35m

$960

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/28

5:15 am-7:05 am

1 stop24h 50m

Santiago Arturo Merino Benitez

Wed 6/10

9:00 pm-10:35 am

1 stop14h 35m

$966

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/6

6:00 am-5:35 am

2 stops21h 35m

Santiago Arturo Merino Benitez

Tue 10/20

12:00 am-6:01 pm

2 stops20h 01m

$971

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/28

1:19 pm-7:05 am

2 stops16h 46m

Santiago Arturo Merino Benitez

Wed 6/10

9:00 pm-4:58 pm

2 stops20h 58m

$997

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 10/6

5:30 pm-1:25 pm

3 stops17h 55m

Santiago Arturo Merino Benitez

Tue 10/20

7:45 pm-10:48 am

2 stops17h 03m

$1,024

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 5/28

10:49 am-10:49 am

3 stops23h 00m

Santiago Arturo Merino Benitez

Wed 6/10

4:10 am-11:56 pm

2 stops20h 46m

$1,032

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 6/16

10:51 am-6:00 am

2 stops18h 09m

Santiago Arturo Merino Benitez

Tue 6/30

8:40 pm-9:46 am

1 stop14h 06m

$1,037

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 5/22

5:20 pm-7:15 am

1 stop12h 55m

Santiago Arturo Merino Benitez

Sat 5/30

11:05 pm-5:56 pm

2 stops19h 51m

$1,041

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $793. If you don’t want to visit Santiago in March, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	12h 45m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 12h 45m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 45m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of April 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 41% of the total bookings. Other popular airlines include American Airlines with 32% and LATAM Airlines with 27%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.9 8,437 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,655 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $803	Free Cancellation	Rating 7.4 1,912 reviews	Search LATAM Airlines flights

Viña del Mar

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Santa Cruz

Valle Nevado

Pichilemu

San Fernando

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.