Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

LATAM Airlines is the most popular carrier operating from Lambert-St Louis to Santiago Arturo Merino Benitez

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$409 Cheap Flights from St. Louis to Santiago in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

9:00 am - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

27h 00m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

11:10 pm - 6:01 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

21h 51m1 stop Atlanta Hartsfield-Jackson

$995LATAM Airlines

Tue, Feb 9 - Wed, Feb 17

3:40 pm - 9:50 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

27h 10m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

8:13 am - 8:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

26h 59m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$995LATAM Airlines

Tue, Feb 9 - Wed, Feb 17

6:00 am - 7:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

22h 40m1 stop Atlanta Hartsfield-Jackson

11:10 pm - 2:43 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 33m1 stop Atlanta Hartsfield-Jackson

$995Delta

Mon, Feb 8 - Thu, Feb 18

9:00 am - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

27h 00m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

9:50 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

15h 58m1 stop Atlanta Hartsfield-Jackson

$995Delta

Tue, Feb 9 - Thu, Feb 18

7:03 am - 9:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

22h 57m1 stop Miami

11:45 pm - 12:32 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

15h 47m1 stop Dallas/Fort Worth

$995American Airlines

Sun, Feb 7 - Fri, Feb 19

6:07 pm - 8:10 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

12h 03m1 stop Miami

10:15 pm - 5:27 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

21h 12m1 stop Miami

$995American Airlines

Mon, Oct 19 - Thu, Oct 29

4:17 pm - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

13h 33m1 stop Houston George Bush Intcntl

10:45 pm - 6:38 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 53m1 stop Houston George Bush Intcntl

$995United Airlines

Mon, Feb 8 - Wed, Feb 17

4:17 pm - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

13h 33m1 stop Houston George Bush Intcntl

10:45 pm - 6:38 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 53m1 stop Houston George Bush Intcntl

$995United Airlines

Tue, Feb 9 - Wed, Feb 17

3:40 pm - 6:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

1:40 pm - 6:01 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

31h 21m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$995LATAM Airlines

Tue, Feb 9 - Thu, Feb 18

1:06 pm - 9:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

16h 54m2 stops Chicago O'Hare Intl Miami

10:15 pm - 12:32 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

17h 17m2 stops Miami Dallas/Fort Worth

$1,000American Airlines

Sun, Feb 7 - Fri, Feb 19

Cheap last minute flights

Enter your travel dates to find the best prices.

5:23 pm - 7:15 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

12h 52m1 stop Atlanta Hartsfield-Jackson

9:30 pm - 5:53 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

45h 23m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,113LATAM Airlines

Sun, Aug 30 - Wed, Sep 2

5:23 pm - 5:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 22m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

9:30 pm - 5:53 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

45h 23m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,118LATAM Airlines

Sun, Aug 30 - Wed, Sep 2

5:23 pm - 7:15 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

12h 52m1 stop Atlanta Hartsfield-Jackson

8:40 pm - 9:20 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 40m1 stop Atlanta Hartsfield-Jackson

$1,254LATAM Airlines

Sun, Aug 30 - Wed, Sep 2

5:23 pm - 3:25 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

33h 02m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

8:30 am - 11:46 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

28h 16m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson

$1,290LATAM Airlines

Sun, Aug 30 - Wed, Sep 2

11:15 am - 3:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

14h 45m2 stops Houston George Bush Intcntl Panama City Tocumen Intl

11:22 am - 8:39 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 17m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$1,381Copa Airlines

Sun, Aug 30 - Tue, Sep 1

5:23 pm - 7:45 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

25h 22m2 stops Atlanta Hartsfield-Jackson Miami

8:40 pm - 6:27 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 47m1 stop Atlanta Hartsfield-Jackson

$1,437LATAM Airlines

Sun, Aug 30 - Tue, Sep 1

5:23 pm - 7:45 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

25h 22m2 stops Atlanta Hartsfield-Jackson Miami

8:30 am - 11:46 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

28h 16m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson

$1,457LATAM Airlines

Sun, Aug 30 - Tue, Sep 1

11:00 am - 7:15 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

19h 15m1 stop Atlanta Hartsfield-Jackson

8:40 pm - 11:46 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

16h 06m1 stop Atlanta Hartsfield-Jackson

$1,469LATAM Airlines

Sun, Aug 30 - Tue, Sep 1

2:40 pm - 3:25 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 45m3 stops Toronto Pearson Intl Punta Cana Lima J Chavez Intl

3:20 pm - 6:42 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

28h 22m3 stops Bogotá El Dorado San José Juan Santamaria Intl Montreal Pierre Elliott Trudeau Intl

$1,687Multiple Airlines

Sun, Aug 30 - Wed, Sep 2

2:40 pm - 3:25 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 45m3 stops Toronto Pearson Intl Punta Cana Lima J Chavez Intl

6:40 am - 2:02 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

32h 22m3 stops Bogotá El Dorado Cancun Toronto Pearson Intl

$2,177Multiple Airlines

Sun, Aug 30 - Tue, Sep 1

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Delta flights from St. Louis to Santiago

Our best Delta deals on St. Louis to Santiago flight tickets

Delta

Feb 8

STL6:00 amLambert-St Louis

22h 40m

1 stop

SCL7:40 amSantiago Arturo Merino Benitez

Feb 18

SCL11:10 pmSantiago Arturo Merino Benitez

18h 33m

1 stop

STL2:43 pmLambert-St Louis

$995

Delta

Feb 7

STL6:59 pmLambert-St Louis

33h 41m

1 stop

SCL7:40 amSantiago Arturo Merino Benitez

Feb 17

SCL11:10 pmSantiago Arturo Merino Benitez

21h 51m

1 stop

STL6:01 pmLambert-St Louis

$1,004

Delta

Feb 6

STL9:00 amLambert-St Louis

19h 15m

2 stops

SCL7:15 amSantiago Arturo Merino Benitez

Feb 18

SCL11:10 pmSantiago Arturo Merino Benitez

14h 38m

1 stop

STL10:48 amLambert-St Louis

$1,035

United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Feb 8

STL1:08 pmLambert-St Louis

16h 42m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Feb 19

SCL10:45 pmSantiago Arturo Merino Benitez

13h 57m

1 stop

STL9:42 amLambert-St Louis

$1,016

United Airlines

Feb 7

STL3:15 pmLambert-St Louis

38h 35m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Feb 17

SCL10:45 pmSantiago Arturo Merino Benitez

18h 45m

2 stops

STL2:30 pmLambert-St Louis

$1,017

United Airlines

Feb 5

STL9:40 amLambert-St Louis

20h 10m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Feb 18

SCL10:45 pmSantiago Arturo Merino Benitez

13h 57m

1 stop

STL9:42 amLambert-St Louis

$1,021

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/9

9:00 am-3:00 pm

2 stops27h 00m

Santiago Arturo Merino Benitez

Wed 2/17

11:10 pm-6:01 pm

1 stop21h 51m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/9

3:40 pm-9:50 pm

2 stops27h 10m

Santiago Arturo Merino Benitez

Wed 2/17

8:13 am-8:12 am

2 stops26h 59m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/8

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

Thu 2/18

11:10 pm-2:43 pm

1 stop18h 33m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/9

9:00 am-3:00 pm

2 stops27h 00m

Santiago Arturo Merino Benitez

Thu 2/18

9:50 pm-10:48 am

1 stop15h 58m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 2/7

7:03 am-9:00 am

1 stop22h 57m

Santiago Arturo Merino Benitez

Fri 2/19

11:45 pm-12:32 pm

1 stop15h 47m

$995

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 10/19

6:07 pm-8:10 am

1 stop12h 03m

Santiago Arturo Merino Benitez

Thu 10/29

10:15 pm-5:27 pm

1 stop21h 12m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/8

4:17 pm-8:50 am

1 stop13h 33m

Santiago Arturo Merino Benitez

Wed 2/17

10:45 pm-6:38 pm

1 stop22h 53m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/9

4:17 pm-8:50 am

1 stop13h 33m

Santiago Arturo Merino Benitez

Wed 2/17

10:45 pm-6:38 pm

1 stop22h 53m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/9

3:40 pm-6:00 pm

2 stops23h 20m

Santiago Arturo Merino Benitez

Thu 2/18

1:40 pm-6:01 pm

2 stops31h 21m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 2/7

1:06 pm-9:00 am

2 stops16h 54m

Santiago Arturo Merino Benitez

Fri 2/19

10:15 pm-12:32 pm

2 stops17h 17m

$1,000

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route.

Typical prices usually range from $1,214 to $1,288.
The lowest price recently found on this route was $995.

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $823. If you don’t want to visit Santiago in March, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $944.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$409
Fastest flight time	12h 40m
Direct flights	None

The best one-way flight to Santiago from St. Louis in the past 72 hours is $409. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $995.

The fastest flight from St. Louis to Santiago takes 12h 40m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 40m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 46% of the total bookings. Other popular airlines include American Airlines with 32% and LATAM Airlines with 22%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,520 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,987 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,991 reviews	Search LATAM Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.