Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

LATAM Airlines and United Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$501 Cheap Flights from St. Louis to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:05 pm - 6:38 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 33m2 stops Toronto Pearson Intl Punta Cana

10:00 am - 11:17 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

28h 17m3 stops Punta Cana Newark Atlanta Hartsfield-Jackson

$1,084Multiple Airlines

Tue, Dec 1 - Thu, Dec 10

4:05 pm - 6:38 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 33m3 stops Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl Punta Cana

10:00 am - 11:17 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

28h 17m3 stops Punta Cana Newark Atlanta Hartsfield-Jackson

$1,087Multiple Airlines

Tue, Dec 1 - Thu, Dec 10

9:00 am - 7:30 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

19h 30m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

8:25 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

17h 23m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,116Delta

Mon, Jan 11 - Wed, Jan 20

9:00 am - 7:30 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

19h 30m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

9:50 pm - 6:01 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

23h 11m1 stop Atlanta Hartsfield-Jackson

$1,116Delta

Mon, Jan 11 - Wed, Jan 20

11:51 am - 5:40 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

26h 49m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

11:10 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

14h 38m1 stop Atlanta Hartsfield-Jackson

$1,116LATAM Airlines

Mon, Feb 15 - Tue, Mar 2

3:40 pm - 5:40 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 00m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

7:05 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 43m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,116LATAM Airlines

Mon, Feb 15 - Tue, Mar 2

6:15 am - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 35m1 stop Houston George Bush Intcntl

10:45 pm - 9:31 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 46m1 stop Houston George Bush Intcntl

$1,116United Airlines

Mon, Jan 11 - Wed, Jan 20

9:00 am - 5:20 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

5:55 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 53m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,116LATAM Airlines

Mon, Feb 15 - Tue, Mar 2

12:21 pm - 8:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 44m1 stop Miami

8:35 pm - 9:20 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 45m1 stop Miami

$1,127American Airlines

Sun, Mar 28 - Sat, Apr 10

11:11 am - 8:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 54m2 stops Charlotte Douglas Miami

8:35 pm - 9:20 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 45m1 stop Miami

$1,131American Airlines

Sun, Mar 28 - Sat, Apr 10

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Feb 15

STL10:05 amLambert-St Louis

19h 45m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Mar 2

SCL10:45 pmSantiago Arturo Merino Benitez

21h 01m

1 stop

STL4:46 pmLambert-St Louis

$1,116

United Airlines

Dec 8

STL1:18 pmLambert-St Louis

16h 32m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Dec 15

SCL10:45 pmSantiago Arturo Merino Benitez

22h 56m

1 stop

STL6:41 pmLambert-St Louis

$1,152

United Airlines

Dec 10

STL10:45 amLambert-St Louis

19h 05m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Dec 17

SCL10:45 pmSantiago Arturo Merino Benitez

25h 37m

2 stops

STL9:22 pmLambert-St Louis

$1,156

American Airlines flights from St. Louis to Santiago

Our best American Airlines deals on St. Louis to Santiago flight tickets

American Airlines

Mar 28

STL11:11 amLambert-St Louis

18h 54m

2 stops

SCL8:05 amSantiago Arturo Merino Benitez

Apr 10

SCL8:35 pmSantiago Arturo Merino Benitez

17h 13m

2 stops

STL12:48 pmLambert-St Louis

$1,131

American Airlines

Feb 27

STL9:01 amLambert-St Louis

19h 44m

1 stop

SCL7:45 amSantiago Arturo Merino Benitez

Mar 6

SCL10:15 pmSantiago Arturo Merino Benitez

16h 16m

1 stop

STL11:31 amLambert-St Louis

$1,263

American Airlines

Dec 28

STL8:26 amLambert-St Louis

20h 34m

1 stop

SCL8:00 amSantiago Arturo Merino Benitez

Jan 16

SCL11:15 pmSantiago Arturo Merino Benitez

18h 40m

1 stop

STL2:55 pmLambert-St Louis

$1,319

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 12/1

4:05 pm-6:38 am

2 stops35h 33m

Santiago Arturo Merino Benitez

Thu 12/10

10:00 am-11:17 am

3 stops28h 17m

$1,084

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 12/1

4:05 pm-6:38 am

3 stops35h 33m

Santiago Arturo Merino Benitez

Thu 12/10

10:00 am-11:17 am

3 stops28h 17m

$1,087

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 1/11

9:00 am-7:30 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Wed 1/20

8:25 pm-10:48 am

2 stops17h 23m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 1/11

9:00 am-7:30 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Wed 1/20

9:50 pm-6:01 pm

1 stop23h 11m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

11:51 am-5:40 pm

2 stops26h 49m

Santiago Arturo Merino Benitez

Tue 3/2

11:10 pm-10:48 am

1 stop14h 38m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

3:40 pm-5:40 pm

2 stops23h 00m

Santiago Arturo Merino Benitez

Tue 3/2

7:05 pm-10:48 am

2 stops18h 43m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 1/11

6:15 am-8:50 am

1 stop23h 35m

Santiago Arturo Merino Benitez

Wed 1/20

10:45 pm-9:31 am

1 stop13h 46m

$1,116

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 2/15

9:00 am-5:20 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Tue 3/2

5:55 pm-10:48 am

2 stops19h 53m

$1,116

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 3/28

12:21 pm-8:05 am

1 stop17h 44m

Santiago Arturo Merino Benitez

Sat 4/10

8:35 pm-9:20 am

1 stop13h 45m

$1,127

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 3/28

11:11 am-8:05 am

2 stops18h 54m

Santiago Arturo Merino Benitez

Sat 4/10

8:35 pm-9:20 am

1 stop13h 45m

$1,131

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route.

Typical prices usually range from $1,258 to $1,405.
The lowest price recently found on this route was $1,084.

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $898. If you don’t want to visit Santiago in March, then you should wait until October to fly from St. Louis, when ticket prices are also cheap, with an average price of $995.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$501
Fastest flight time	17h 04m
Direct flights	None

The best one-way flight to Santiago from St. Louis in the past 72 hours is $501. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $1,084.

The fastest flight from St. Louis to Santiago takes 17h 04m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 17h 04m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of October 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 51% of the total bookings. Other popular airlines include American Airlines with 27% and LATAM Airlines with 22%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $762	Free Cancellation	Rating 7.0 12,189 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,969 reviews	Search LATAM Airlines flights
Delta	PriceFrom $858	Free Cancellation	Rating 7.8 8,681 reviews	Search Delta flights

Viña del Mar

Valparaíso

Santa Cruz

San Fernando

Valle Nevado

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.