Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines is the most popular carrier operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$657 Cheap Flights from St. Louis to Santiago in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:11 pm - 8:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

15h 49m1 stop Miami

9:30 pm - 2:30 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 00m2 stops Miami Dallas/Fort Worth

$991American Airlines

Thu, Sep 24 - Wed, Oct 7

6:20 pm - 8:10 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

11h 50m1 stop Miami

10:15 pm - 5:25 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 10m1 stop Miami

$995American Airlines

Wed, Oct 21 - Wed, Nov 4

11:00 am - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 50m1 stop Houston George Bush Intcntl

10:45 pm - 6:38 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 53m1 stop Houston George Bush Intcntl

$995United Airlines

Tue, Feb 2 - Tue, Feb 16

1:08 pm - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

16h 42m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 pm - 6:38 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 53m1 stop Houston George Bush Intcntl

$995United Airlines

Tue, Feb 2 - Tue, Feb 16

5:00 pm - 9:00 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

13h 00m1 stop Miami

11:45 pm - 4:36 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

19h 51m1 stop Dallas/Fort Worth

$995American Airlines

Tue, Nov 17 - Mon, Dec 7

7:05 am - 8:15 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

23h 10m1 stop Atlanta Hartsfield-Jackson

8:40 pm - 9:09 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

14h 29m1 stop Atlanta Hartsfield-Jackson

$1,000Delta

Thu, Sep 24 - Wed, Oct 7

10:00 am - 7:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 40m1 stop Atlanta Hartsfield-Jackson

8:40 am - 11:56 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 16m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,000LATAM Airlines

Tue, Nov 17 - Mon, Dec 7

6:50 pm - 8:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 00m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 pm - 4:51 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

21h 06m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,000United Airlines

Sun, Nov 1 - Thu, Nov 12

11:51 am - 7:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

16h 49m1 stop Atlanta Hartsfield-Jackson

9:50 pm - 8:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 22m1 stop Atlanta Hartsfield-Jackson

$1,007Delta

Mon, Dec 21 - Tue, Dec 29

11:00 am - 10:49 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

22h 49m3 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl Buenos Aires Jorge Newbery

1:35 pm - 11:46 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

24h 11m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,007LATAM Airlines

Tue, Sep 1 - Sun, Sep 6

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Delta flights from St. Louis to Santiago

Our best Delta deals on St. Louis to Santiago flight tickets

Delta

Jan 7

STL7:20 amLambert-St Louis

19h 00m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Jan 23

SCL8:13 amSantiago Arturo Merino Benitez

18h 26m

2 stops

STL11:39 pmLambert-St Louis

$1,026

Delta

Sep 25

STL10:05 amLambert-St Louis

20h 10m

1 stop

SCL8:15 amSantiago Arturo Merino Benitez

Oct 3

SCL8:40 pmSantiago Arturo Merino Benitez

14h 20m

1 stop

STL9:00 amLambert-St Louis

$1,047

Delta

Dec 21

STL11:51 amLambert-St Louis

16h 49m

1 stop

SCL7:40 amSantiago Arturo Merino Benitez

Dec 31

SCL9:50 pmSantiago Arturo Merino Benitez

13h 22m

1 stop

STL8:12 amLambert-St Louis

$1,211

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Sep 1

STL11:00 amLambert-St Louis

22h 49m

3 stops

SCL10:49 amSantiago Arturo Merino Benitez

Sep 6

SCL10:30 pmSantiago Arturo Merino Benitez

27h 28m

2 stops

STL11:58 pmLambert-St Louis

$1,007

LATAM Airlines

Nov 17

STL2:31 pmLambert-St Louis

20h 54m

3 stops

SCL2:25 pmSantiago Arturo Merino Benitez

Dec 7

SCL10:20 amSantiago Arturo Merino Benitez

16h 36m

2 stops

STL11:56 pmLambert-St Louis

$1,010

LATAM Airlines

Sep 16

STL2:30 pmLambert-St Louis

21h 55m

3 stops

SCL2:25 pmSantiago Arturo Merino Benitez

Sep 23

SCL5:10 amSantiago Arturo Merino Benitez

20h 32m

2 stops

STL11:42 pmLambert-St Louis

$1,012

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 9/24

2:11 pm-8:00 am

1 stop15h 49m

Santiago Arturo Merino Benitez

Wed 10/7

9:30 pm-2:30 pm

2 stops19h 00m

$991

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 10/21

6:20 pm-8:10 am

1 stop11h 50m

Santiago Arturo Merino Benitez

Wed 11/4

10:15 pm-5:25 pm

1 stop22h 10m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/2

11:00 am-8:50 am

1 stop18h 50m

Santiago Arturo Merino Benitez

Tue 2/16

10:45 pm-6:38 pm

1 stop22h 53m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 2/2

1:08 pm-8:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Tue 2/16

10:45 pm-6:38 pm

1 stop22h 53m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 11/17

5:00 pm-9:00 am

1 stop13h 00m

Santiago Arturo Merino Benitez

Mon 12/7

11:45 pm-4:36 pm

1 stop19h 51m

$995

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 9/24

7:05 am-8:15 am

1 stop23h 10m

Santiago Arturo Merino Benitez

Wed 10/7

8:40 pm-9:09 am

1 stop14h 29m

$1,000

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 11/17

10:00 am-7:40 am

1 stop18h 40m

Santiago Arturo Merino Benitez

Mon 12/7

8:40 am-11:56 pm

2 stops18h 16m

$1,000

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 11/1

6:50 pm-8:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Thu 11/12

10:45 pm-4:51 pm

2 stops21h 06m

$1,000

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Mon 12/21

11:51 am-7:40 am

1 stop16h 49m

Santiago Arturo Merino Benitez

Tue 12/29

9:50 pm-8:12 am

1 stop13h 22m

$1,007

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 9/1

11:00 am-10:49 am

3 stops22h 49m

Santiago Arturo Merino Benitez

Sun 9/6

1:35 pm-11:46 am

2 stops24h 11m

$1,007

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $823. If you don’t want to visit Santiago in March, then you should wait until October to fly from St. Louis, when ticket prices are also cheap, with an average price of $1,003.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	16h 59m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 16h 59m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 16h 59m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of August 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 40% of the total bookings. Other popular airlines include American Airlines with 34% and LATAM Airlines with 26%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,493 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,866 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,973 reviews	Search LATAM Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.