Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

American Airlines and Delta are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of May 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$427 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently high for flights on this route. Typical prices usually range from $1,112 to $1,088. The lowest price recently found on this route was $1,176.

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Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

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4:19 pm - 6:00 am

STL

SCL

36h 41m

2 stops

9:30 am - 2:39 pm

SCL

STL

30h 09m

1 stop

$1,176Multiple Airlines

Wed, May 27 - Sun, Jun 7

4:19 pm - 7:23 pm

STL

SCL

50h 04m

2 stops

9:30 am - 2:37 pm

SCL

STL

30h 07m

1 stop

$1,202Multiple Airlines

Fri, Jun 5 - Sun, Jun 14

3:57 pm - 7:15 am

STL

SCL

14h 18m

1 stop

8:40 pm - 5:53 pm

SCL

STL

22h 13m

1 stop

$1,219LATAM Airlines

Fri, Jul 3 - Sat, Jul 11

7:01 am - 4:59 am

STL

SCL

20h 58m

2 stops

1:06 am - 10:09 am

SCL

STL

35h 03m

2 stops

$1,228United Airlines

Tue, Sep 1 - Sat, Sep 5

1:30 pm - 6:55 am

STL

SCL

16h 25m

2 stops

10:55 pm - 4:55 pm

SCL

STL

20h 00m

1 stop

$1,232LATAM Airlines

Wed, Sep 2 - Mon, Sep 7

1:39 pm - 7:15 am

STL

SCL

16h 36m

1 stop

8:40 pm - 12:17 pm

SCL

STL

16h 37m

1 stop

$1,235Delta

Fri, Jul 3 - Sat, Jul 11

8:00 am - 6:00 am

STL

SCL

21h 00m

2 stops

11:25 pm - 7:00 pm

SCL

STL

20h 35m

2 stops

$1,240Delta

Fri, Jul 3 - Sat, Jul 11

11:35 am - 6:50 am

STL

SCL

18h 15m

1 stop

9:30 pm - 10:45 am

SCL

STL

15h 15m

1 stop

$1,245American Airlines

Wed, Sep 2 - Mon, Sep 7

11:51 am - 7:15 am

STL

SCL

18h 24m

1 stop

9:25 pm - 11:37 pm

SCL

STL

28h 12m

2 stops

$1,247LATAM Airlines

Tue, Sep 1 - Sun, Sep 6

10:16 am - 6:50 am

STL

SCL

19h 34m

2 stops

9:30 pm - 10:45 am

SCL

STL

15h 15m

1 stop

$1,250American Airlines

Wed, Sep 2 - Mon, Sep 7

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Jul 3

STL3:57 pmLambert-St Louis

14h 18m

1 stop

SCL7:15 amSantiago Arturo Merino Benitez

Jul 11

SCL8:40 pmSantiago Arturo Merino Benitez

22h 13m

1 stop

STL5:53 pmLambert-St Louis

$1,219

LATAM Airlines

Sep 2

STL1:30 pmLambert-St Louis

16h 25m

2 stops

SCL6:55 amSantiago Arturo Merino Benitez

Sep 7

SCL10:55 pmSantiago Arturo Merino Benitez

20h 00m

1 stop

STL4:55 pmLambert-St Louis

$1,232

LATAM Airlines

Sep 1

STL11:51 amLambert-St Louis

18h 24m

1 stop

SCL7:15 amSantiago Arturo Merino Benitez

Sep 6

SCL9:25 pmSantiago Arturo Merino Benitez

28h 12m

2 stops

STL11:37 pmLambert-St Louis

$1,247

GOL flights from St. Louis to Santiago

Our best GOL deals on St. Louis to Santiago flight tickets

GOL

Oct 16

STL6:08 pmLambert-St Louis

11h 42m

1 stop

SCL7:50 amSantiago Arturo Merino Benitez

Nov 3

SCL10:15 pmSantiago Arturo Merino Benitez

20h 35m

1 stop

STL3:50 pmLambert-St Louis

$1,778

GOL

Oct 16

STL1:24 pmLambert-St Louis

16h 26m

2 stops

SCL7:50 amSantiago Arturo Merino Benitez

Nov 3

SCL10:15 pmSantiago Arturo Merino Benitez

18h 02m

2 stops

STL1:17 pmLambert-St Louis

$1,782

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 5/27

4:19 pm-6:00 am

2 stops36h 41m

Santiago Arturo Merino Benitez

Sun 6/7

9:30 am-2:39 pm

1 stop30h 09m

$1,176

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 6/5

4:19 pm-7:23 pm

2 stops50h 04m

Santiago Arturo Merino Benitez

Sun 6/14

9:30 am-2:37 pm

1 stop30h 07m

$1,202

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

3:57 pm-7:15 am

1 stop14h 18m

Santiago Arturo Merino Benitez

Sat 7/11

8:40 pm-5:53 pm

1 stop22h 13m

$1,219

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

7:01 am-4:59 am

2 stops20h 58m

Santiago Arturo Merino Benitez

Sat 9/5

1:06 am-10:09 am

2 stops35h 03m

$1,228

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

1:30 pm-6:55 am

2 stops16h 25m

Santiago Arturo Merino Benitez

Mon 9/7

10:55 pm-4:55 pm

1 stop20h 00m

$1,232

Quickest round-trip

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

1:39 pm-7:15 am

1 stop16h 36m

Santiago Arturo Merino Benitez

Sat 7/11

8:40 pm-12:17 pm

1 stop16h 37m

$1,235

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 7/3

8:00 am-6:00 am

2 stops21h 00m

Santiago Arturo Merino Benitez

Sat 7/11

11:25 pm-7:00 pm

2 stops20h 35m

$1,240

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

11:35 am-6:50 am

1 stop18h 15m

Santiago Arturo Merino Benitez

Mon 9/7

9:30 pm-10:45 am

1 stop15h 15m

$1,245

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 9/1

11:51 am-7:15 am

1 stop18h 24m

Santiago Arturo Merino Benitez

Sun 9/6

9:25 pm-11:37 pm

2 stops28h 12m

$1,247

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/2

10:16 am-6:50 am

2 stops19h 34m

Santiago Arturo Merino Benitez

Mon 9/7

9:30 pm-10:45 am

1 stop15h 15m

$1,250

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $793. If you don’t want to visit Santiago in March, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $883.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	14h 18m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 14h 18m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

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Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 14h 18m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of May 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 44% of the total bookings. Other popular airlines include American Airlines with 29% and LATAM Airlines with 26%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.9 8,455 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 11,667 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,917 reviews	Search LATAM Airlines flights

Viña del Mar

Valparaíso

Santa Cruz

Valle Nevado

Pichilemu

San Fernando

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.