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Cheap flights from St. Louis to Santiago from $549

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 12/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Santiago (STL-SCL)

Cheap round-trip flights

Delta Logo
3:15 pm - 7:00 amSTL-SCL
12h 45m1 stop
Delta Logo
9:30 pm - 8:09 amSCL-STL
13h 39m1 stop
$784Delta
Find Deal
Thu, Nov 27 - Mon, Dec 8
LATAM Airlines Logo
1:30 pm - 7:00 amSTL-SCL
14h 30m2 stops
LATAM Airlines Logo
6:30 pm - 10:46 amSCL-STL
19h 16m2 stops
$788LATAM Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15
Delta Logo
10:00 am - 6:10 amSTL-SCL
17h 10m1 stop
Delta Logo
11:15 pm - 9:04 amSCL-STL
12h 49m1 stop
$804Delta
Find Deal
Wed, Jan 7 - Thu, Jan 15
Delta Logo
7:05 pm - 6:10 amSTL-SCL
32h 05m1 stop
Delta Logo
8:20 am - 11:40 pmSCL-STL
18h 20m2 stops
$812Delta
Find Deal
Sun, Jan 11 - Tue, Jan 20
LATAM Airlines Logo
6:42 pm - 3:00 pmSTL-SCL
18h 18m2 stops
LATAM Airlines Logo
5:55 pm - 9:59 amSCL-STL
18h 04m2 stops
$824LATAM Airlines
Find Deal
Thu, Sep 18 - Sun, Sep 28
LATAM Airlines Logo
11:04 am - 6:00 amSTL-SCL
16h 56m2 stops
LATAM Airlines Logo
12:25 am - 9:15 pmSCL-STL
22h 50m2 stops
$829LATAM Airlines
Find Deal
Wed, Sep 17 - Sat, Sep 27
United Airlines Logo
6:00 am - 8:50 amSTL-SCL
23h 50m1 stop
United Airlines Logo
10:45 pm - 4:27 pmSCL-STL
44h 42m2 stops
$863United Airlines
Find Deal
Thu, Dec 25 - Sat, Jan 3
United Airlines Logo
6:30 am - 8:50 amSTL-SCL
23h 20m2 stops
United Airlines Logo
10:45 pm - 4:27 pmSCL-STL
44h 42m2 stops
$900United Airlines
Find Deal
Thu, Dec 25 - Sat, Jan 3
Air Canada Logo
4:05 pm - 12:15 pmSTL-SCL
17h 10m1 stop
Air Canada Logo
8:55 pm - 3:29 pmSCL-STL
21h 34m1 stop
$942Air Canada
Find Deal
Tue, Jan 13 - Mon, Jan 19
Air Canada Logo
4:05 pm - 12:15 pmSTL-SCL
17h 10m1 stop
Air Canada Logo
8:55 pm - 3:29 pmSCL-STL
21h 34m1 stop
$1,067Air Canada
Find Deal
Sun, Jan 11 - Wed, Jan 14

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets
LATAM Airlines
Dec 11
STL1:30 pmLambert-St Louis
14h 30m
2 stops
SCL7:00 amSantiago Arturo Merino Benitez
Dec 15
SCL6:30 pmSantiago Arturo Merino Benitez
19h 16m
2 stops
STL10:46 amLambert-St Louis
$788
Find similar
LATAM Airlines
Sep 18
STL6:42 pmLambert-St Louis
18h 18m
2 stops
SCL3:00 pmSantiago Arturo Merino Benitez
Sep 28
SCL5:55 pmSantiago Arturo Merino Benitez
18h 04m
2 stops
STL9:59 amLambert-St Louis
$824
Find similar
LATAM Airlines
Sep 17
STL11:04 amLambert-St Louis
16h 56m
2 stops
SCL6:00 amSantiago Arturo Merino Benitez
Sep 27
SCL12:25 amSantiago Arturo Merino Benitez
22h 50m
2 stops
STL9:15 pmLambert-St Louis
$829
Find similar

Air Canada flights from St. Louis to Santiago

Our best Air Canada deals on St. Louis to Santiago flight tickets
Air Canada
Jan 13
STL4:05 pmLambert-St Louis
17h 10m
1 stop
SCL12:15 pmSantiago Arturo Merino Benitez
Jan 19
SCL8:55 pmSantiago Arturo Merino Benitez
21h 34m
1 stop
STL3:29 pmLambert-St Louis
$942
Find similar
Air Canada
Jan 11
STL4:05 pmLambert-St Louis
17h 10m
1 stop
SCL12:15 pmSantiago Arturo Merino Benitez
Jan 14
SCL8:55 pmSantiago Arturo Merino Benitez
21h 34m
1 stop
STL3:29 pmLambert-St Louis
$1,067
Find similar
Air Canada
Dec 24
STL4:05 pmLambert-St Louis
17h 10m
1 stop
SCL12:15 pmSantiago Arturo Merino Benitez
Jan 6
SCL8:55 pmSantiago Arturo Merino Benitez
21h 34m
1 stop
STL3:29 pmLambert-St Louis
$1,087
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

3:15 pm-7:00 am

1 stop12h 45m

Santiago Arturo Merino Benitez

Mon 12/8

9:30 pm-8:09 am

1 stop13h 39m

$784

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

1:30 pm-7:00 am

2 stops14h 30m

Santiago Arturo Merino Benitez

Mon 12/15

6:30 pm-10:46 am

2 stops19h 16m

$788

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 1/7

10:00 am-6:10 am

1 stop17h 10m

Santiago Arturo Merino Benitez

Thu 1/15

11:15 pm-9:04 am

1 stop12h 49m

$804

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 1/11

7:05 pm-6:10 am

1 stop32h 05m

Santiago Arturo Merino Benitez

Tue 1/20

8:20 am-11:40 pm

2 stops18h 20m

$812

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 9/18

6:42 pm-3:00 pm

2 stops18h 18m

Santiago Arturo Merino Benitez

Sun 9/28

5:55 pm-9:59 am

2 stops18h 04m

$824

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 9/17

11:04 am-6:00 am

2 stops16h 56m

Santiago Arturo Merino Benitez

Sat 9/27

12:25 am-9:15 pm

2 stops22h 50m

$829

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/25

6:00 am-8:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Sat 1/3

10:45 pm-4:27 pm

2 stops44h 42m

$863

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/25

6:30 am-8:50 am

2 stops23h 20m

Santiago Arturo Merino Benitez

Sat 1/3

10:45 pm-4:27 pm

2 stops44h 42m

$900

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 1/13

4:05 pm-12:15 pm

1 stop17h 10m

Santiago Arturo Merino Benitez

Mon 1/19

8:55 pm-3:29 pm

1 stop21h 34m

$942

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 1/11

4:05 pm-12:15 pm

1 stop17h 10m

Santiago Arturo Merino Benitez

Wed 1/14

8:55 pm-3:29 pm

1 stop21h 34m

$1,067

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $772. If you don’t want to visit Santiago in October, then you should wait until July to fly from St. Louis, when ticket prices are also cheap, with an average price of $878.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $955. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,189.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from St. Louis to Santiago when you can find flight prices for as low as $982. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,074 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $971 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from St. Louis for as low as $902 on momondo.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found

$549

Fastest flight time

12h 00m

Direct flights

None

Airports in Santiago

1 airport
The best one-way flight to Santiago from St. Louis in the past 72 hours is $549. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $784.
The fastest flight from St. Louis to Santiago takes 12h 00m
There are no direct flights from St. Louis to Santiago. Popular non-direct route for this connection is Lambert-St Louis Airport - Santiago Arturo Merino Benitez Airport.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?

    The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 12h 00m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santiago?

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $742Free CancellationRating
8.0
7,980 reviews
Search Delta flights
LATAM AirlinesPriceFrom $762Free CancellationRating
7.5
1,840 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $823Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $883Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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