Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

Air Canada and American Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

What airlines fly to Santiago?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of September 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$587 Cheap Flights from St. Louis to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:00 am - 7:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

21h 45m1 stop Dallas/Fort Worth

10:15 pm - 5:22 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 07m1 stop Miami

$1,015American Airlines

Thu, Jan 28 - Fri, Feb 5

12:50 pm - 7:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

15h 55m1 stop Dallas/Fort Worth

10:15 pm - 5:22 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 07m1 stop Miami

$1,015American Airlines

Wed, Jan 27 - Fri, Feb 5

7:00 am - 7:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

21h 45m1 stop Dallas/Fort Worth

10:15 pm - 1:28 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 13m2 stops Miami Chicago O'Hare Intl

$1,020American Airlines

Thu, Jan 28 - Fri, Feb 5

6:50 pm - 7:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 00m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 pm - 2:13 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 28m1 stop Houston George Bush Intcntl

$1,031United Airlines

Thu, Oct 29 - Thu, Nov 5

6:50 pm - 7:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 00m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 pm - 9:40 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

25h 55m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,031United Airlines

Thu, Oct 29 - Thu, Nov 5

6:00 am - 7:55 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

22h 55m3 stops Atlanta Hartsfield-Jackson Miami Punta Cana

8:25 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

17h 23m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,041LATAM Airlines

Wed, Jan 27 - Fri, Feb 5

3:40 pm - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

20h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

11:10 pm - 10:48 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

14h 38m1 stop Atlanta Hartsfield-Jackson

$1,045Delta

Sat, Feb 20 - Sat, Mar 6

9:00 am - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

27h 00m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

8:13 am - 11:39 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 26m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,045LATAM Airlines

Sat, Feb 20 - Sat, Mar 6

1:08 pm - 7:50 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

16h 42m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 pm - 6:38 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 53m1 stop Houston George Bush Intcntl

$1,056United Airlines

Tue, Oct 27 - Tue, Nov 3

6:00 am - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

21h 40m1 stop Atlanta Hartsfield-Jackson

8:25 pm - 4:04 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

22h 39m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,065Delta

Fri, Dec 11 - Thu, Dec 24

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Jan 27

STL6:00 amLambert-St Louis

22h 55m

3 stops

SCL7:55 amSantiago Arturo Merino Benitez

Feb 5

SCL8:25 pmSantiago Arturo Merino Benitez

17h 23m

2 stops

STL10:48 amLambert-St Louis

$1,041

LATAM Airlines

Dec 11

STL12:36 pmLambert-St Louis

15h 04m

1 stop

SCL6:40 amSantiago Arturo Merino Benitez

Dec 24

SCL11:00 pmSantiago Arturo Merino Benitez

22h 19m

1 stop

STL6:19 pmLambert-St Louis

$1,053

LATAM Airlines

Dec 11

STL6:00 amLambert-St Louis

21h 40m

1 stop

SCL6:40 amSantiago Arturo Merino Benitez

Dec 24

SCL8:40 amSantiago Arturo Merino Benitez

16h 29m

2 stops

STL10:09 pmLambert-St Louis

$1,059

United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Oct 29

STL6:50 pmLambert-St Louis

35h 00m

2 stops

SCL7:50 amSantiago Arturo Merino Benitez

Nov 5

SCL10:45 pmSantiago Arturo Merino Benitez

25h 55m

2 stops

STL9:40 pmLambert-St Louis

$1,031

United Airlines

Oct 27

STL1:08 pmLambert-St Louis

16h 42m

2 stops

SCL7:50 amSantiago Arturo Merino Benitez

Nov 3

SCL10:45 pmSantiago Arturo Merino Benitez

22h 53m

1 stop

STL6:38 pmLambert-St Louis

$1,056

United Airlines

Oct 27

STL7:30 amLambert-St Louis

22h 20m

2 stops

SCL7:50 amSantiago Arturo Merino Benitez

Nov 3

SCL10:45 pmSantiago Arturo Merino Benitez

21h 14m

2 stops

STL4:59 pmLambert-St Louis

$1,061

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 1/28

7:00 am-7:45 am

1 stop21h 45m

Santiago Arturo Merino Benitez

Fri 2/5

10:15 pm-5:22 pm

1 stop22h 07m

$1,015

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 1/27

12:50 pm-7:45 am

1 stop15h 55m

Santiago Arturo Merino Benitez

Fri 2/5

10:15 pm-5:22 pm

1 stop22h 07m

$1,015

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 1/28

7:00 am-7:45 am

1 stop21h 45m

Santiago Arturo Merino Benitez

Fri 2/5

10:15 pm-1:28 pm

2 stops18h 13m

$1,020

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 10/29

6:50 pm-7:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Thu 11/5

10:45 pm-2:13 pm

1 stop18h 28m

$1,031

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 10/29

6:50 pm-7:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Thu 11/5

10:45 pm-9:40 pm

2 stops25h 55m

$1,031

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 1/27

6:00 am-7:55 am

3 stops22h 55m

Santiago Arturo Merino Benitez

Fri 2/5

8:25 pm-10:48 am

2 stops17h 23m

$1,041

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 2/20

3:40 pm-3:00 pm

2 stops20h 20m

Santiago Arturo Merino Benitez

Sat 3/6

11:10 pm-10:48 am

1 stop14h 38m

$1,045

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sat 2/20

9:00 am-3:00 pm

2 stops27h 00m

Santiago Arturo Merino Benitez

Sat 3/6

8:13 am-11:39 pm

2 stops18h 26m

$1,045

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 10/27

1:08 pm-7:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Tue 11/3

10:45 pm-6:38 pm

1 stop22h 53m

$1,056

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Fri 12/11

6:00 am-6:40 am

1 stop21h 40m

Santiago Arturo Merino Benitez

Thu 12/24

8:25 pm-4:04 pm

2 stops22h 39m

$1,065

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $764. If you don’t want to visit Santiago in March, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $944.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$587
Fastest flight time	13h 00m
Direct flights	None

The best one-way flight to Santiago from St. Louis in the past 72 hours is $587. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $1,015.

The fastest flight from St. Louis to Santiago takes 13h 00m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 13h 00m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of September 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 46% of the total bookings. Other popular airlines include American Airlines with 30% and LATAM Airlines with 24%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $611	Free Cancellation	Rating 7.8 8,568 reviews	Search Delta flights
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.1 12,056 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,985 reviews	Search LATAM Airlines flights

Viña del Mar

Valparaíso

Santa Cruz

San Fernando

Valle Nevado

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.