Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 83% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What airlines fly to Santiago?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Miami (MIA) has the shortest average layover time for this route: 2h 21m.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

LATAM Airlines and United Airlines are the most popular carriers operating from Lambert-St Louis to Santiago Arturo Merino Benitez

Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of February 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$499 Cheap Flights from St. Louis to Santiago in 2026

Q: What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $930 to $1,225. The lowest price recently found on this route was $865.

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Find the cheapest flights from St. Louis to Santiago

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One-way

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5:30 pm - 7:15 am

STL

SCL

12h 45m

1 stop

10:55 pm - 4:55 pm

SCL

STL

19h 00m

1 stop

$865Delta

Thu, Aug 13 - Sat, Aug 22

1:30 pm - 12:40 pm

STL

SCL

22h 10m

3 stops

11:00 pm - 6:02 pm

SCL

STL

20h 02m

2 stops

$870LATAM Airlines

Thu, Aug 13 - Sat, Aug 22

6:00 am - 4:30 am

STL

SCL

20h 30m

2 stops

8:50 am - 11:58 pm

SCL

STL

17h 08m

2 stops

$898LATAM Airlines

Fri, Mar 20 - Mon, Mar 30

12:04 pm - 5:35 am

STL

SCL

15h 31m

2 stops

6:40 am - 11:58 pm

SCL

STL

19h 18m

2 stops

$905LATAM Airlines

Wed, Mar 11 - Mon, Mar 23

6:00 am - 5:35 am

STL

SCL

21h 35m

2 stops

4:35 am - 11:58 pm

SCL

STL

21h 23m

2 stops

$913LATAM Airlines

Wed, Mar 11 - Mon, Mar 23

5:24 am - 7:05 am

STL

SCL

24h 41m

1 stop

8:30 pm - 10:34 am

SCL

STL

15h 04m

1 stop

$915American Airlines

Sat, May 16 - Sat, Aug 1

4:47 pm - 7:50 am

STL

SCL

13h 03m

1 stop

9:45 pm - 10:59 pm

SCL

STL

27h 14m

2 stops

$917United Airlines

Wed, Mar 11 - Mon, Mar 23

9:10 am - 7:05 am

STL

SCL

20h 55m

2 stops

8:30 pm - 10:34 am

SCL

STL

15h 04m

1 stop

$920American Airlines

Sat, May 16 - Sat, Aug 1

6:00 am - 7:50 am

STL

SCL

23h 50m

1 stop

9:45 pm - 10:59 pm

SCL

STL

27h 14m

2 stops

$921United Airlines

Wed, Mar 11 - Mon, Mar 23

6:20 pm - 9:05 am

STL

SCL

12h 45m

1 stop

9:20 pm - 10:32 am

SCL

STL

15h 12m

1 stop

$926American Airlines

Wed, Mar 11 - Mon, Mar 23

United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Mar 11

STL4:47 pmLambert-St Louis

13h 03m

1 stop

SCL7:50 amSantiago Arturo Merino Benitez

Mar 23

SCL9:45 pmSantiago Arturo Merino Benitez

27h 14m

2 stops

STL10:59 pmLambert-St Louis

$917

United Airlines

Mar 11

STL6:00 amLambert-St Louis

23h 50m

1 stop

SCL7:50 amSantiago Arturo Merino Benitez

Mar 23

SCL9:45 pmSantiago Arturo Merino Benitez

27h 14m

2 stops

STL10:59 pmLambert-St Louis

$921

United Airlines

Mar 2

STL4:49 pmLambert-St Louis

37h 01m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Mar 18

SCL9:45 pmSantiago Arturo Merino Benitez

22h 15m

2 stops

STL6:00 pmLambert-St Louis

$938

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Aug 13

STL1:30 pmLambert-St Louis

22h 10m

3 stops

SCL12:40 pmSantiago Arturo Merino Benitez

Aug 22

SCL11:00 pmSantiago Arturo Merino Benitez

20h 02m

2 stops

STL6:02 pmLambert-St Louis

$870

LATAM Airlines

Mar 20

STL6:00 amLambert-St Louis

20h 30m

2 stops

SCL4:30 amSantiago Arturo Merino Benitez

Mar 30

SCL8:50 amSantiago Arturo Merino Benitez

17h 08m

2 stops

STL11:58 pmLambert-St Louis

$898

LATAM Airlines

Mar 11

STL12:04 pmLambert-St Louis

15h 31m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Mar 23

SCL6:40 amSantiago Arturo Merino Benitez

19h 18m

2 stops

STL11:58 pmLambert-St Louis

$905

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 8/13

5:30 pm-7:15 am

1 stop12h 45m

Santiago Arturo Merino Benitez

Sat 8/22

10:55 pm-4:55 pm

1 stop19h 00m

$865

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 8/13

1:30 pm-12:40 pm

3 stops22h 10m

Santiago Arturo Merino Benitez

Sat 8/22

11:00 pm-6:02 pm

2 stops20h 02m

$870

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 3/20

6:00 am-4:30 am

2 stops20h 30m

Santiago Arturo Merino Benitez

Mon 3/30

8:50 am-11:58 pm

2 stops17h 08m

$898

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:04 pm-5:35 am

2 stops15h 31m

Santiago Arturo Merino Benitez

Mon 3/23

6:40 am-11:58 pm

2 stops19h 18m

$905

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-5:35 am

2 stops21h 35m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-11:58 pm

2 stops21h 23m

$913

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 5/16

5:24 am-7:05 am

1 stop24h 41m

Santiago Arturo Merino Benitez

Sat 8/1

8:30 pm-10:34 am

1 stop15h 04m

$915

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

4:47 pm-7:50 am

1 stop13h 03m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-10:59 pm

2 stops27h 14m

$917

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 5/16

9:10 am-7:05 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Sat 8/1

8:30 pm-10:34 am

1 stop15h 04m

$920

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-10:59 pm

2 stops27h 14m

$921

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:20 pm-9:05 am

1 stop12h 45m

Santiago Arturo Merino Benitez

Mon 3/23

9:20 pm-10:32 am

1 stop15h 12m

$926

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

What is the cheapest month to fly to Santiago?

In general, July is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $883. If you don’t want to visit Santiago in July, then you should wait until December to fly from St. Louis, when ticket prices are also cheap, with an average price of $903.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Fastest flight time	19h 35m
Direct flights	None

The fastest flight from St. Louis to Santiago takes 19h 35m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 19h 35m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of February 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 39% of the total bookings. Other popular airlines include LATAM Airlines with 31% and American Airlines with 29%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $689	Free Cancellation	Rating 7.2 11,304 reviews	Search American Airlines flights
Delta	PriceFrom $755	Free Cancellation	Rating 7.9 8,208 reviews	Search Delta flights
LATAM Airlines	PriceFrom $803	Free Cancellation	Rating 7.5 1,920 reviews	Search LATAM Airlines flights

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Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.