Which layover airport has the shortest travel time from St. Louis to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 12h 45m.

Which layover airport has the shortest connection time from St. Louis to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 2h 05m.

Which airport is the most popular layover for flights between St. Louis and Santiago?

Atlanta (ATL) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Santiago?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to Santiago from St. Louis according to our data. Delta is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport offers the lowest fares from St. Louis to Santiago?

Flights via Miami (MIA) offer the lowest average round-trip price of $898.

What is the cheapest airline that flies from Lambert-St Louis to Santiago Arturo Merino Benitez?

Delta is the most popular carrier operating from Lambert-St Louis to Santiago Arturo Merino Benitez

When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

As of November 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$428 Cheap Flights from St. Louis to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santiago

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One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:04 pm - 5:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 41m3 stops Denver Intl Orlando Bogotá El Dorado

4:15 pm - 12:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

34h 57m2 stops Bogotá El Dorado Orlando

$742Multiple Airlines

Wed, Nov 25 - Wed, Dec 9

3:04 pm - 5:45 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 41m3 stops Denver Intl Orlando Bogotá El Dorado

4:15 pm - 12:12 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

34h 57m2 stops Bogotá El Dorado Orlando

$756Multiple Airlines

Wed, Nov 25 - Wed, Dec 9

3:48 pm - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

11h 52m1 stop Atlanta Hartsfield-Jackson

8:15 am - 6:41 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

37h 26m3 stops Punta Cana Miami Atlanta Hartsfield-Jackson

$1,057LATAM Airlines

Tue, Dec 22 - Fri, Jan 8

1:20 pm - 3:38 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

35h 18m2 stops Orlando Panama City Tocumen Intl

5:00 am - 6:14 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

16h 14m1 stop Punta Cana

$1,127Multiple Airlines

Wed, Nov 25 - Wed, Dec 9

3:48 pm - 3:00 pmSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

20h 12m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

11:00 pm - 9:17 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 17m1 stop Atlanta Hartsfield-Jackson

$1,166Delta

Wed, Jan 13 - Thu, Jan 28

10:12 am - 7:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

18h 28m1 stop Atlanta Hartsfield-Jackson

9:50 pm - 9:17 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

14h 27m1 stop Atlanta Hartsfield-Jackson

$1,166Delta

Thu, Jan 14 - Mon, Feb 1

12:00 pm - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

15h 40m1 stop Atlanta Hartsfield-Jackson

7:40 am - 11:26 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

18h 46m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,166LATAM Airlines

Tue, Jan 19 - Mon, Feb 1

3:45 pm - 8:35 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

13h 50m1 stop Dallas/Fort Worth

8:35 pm - 9:20 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 45m1 stop Miami

$1,166American Airlines

Sun, Jan 10 - Thu, May 6

6:00 am - 6:40 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

21h 40m1 stop Atlanta Hartsfield-Jackson

11:00 pm - 9:17 amSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

13h 17m1 stop Atlanta Hartsfield-Jackson

$1,166LATAM Airlines

Wed, Jan 13 - Wed, Jan 27

1:49 pm - 10:05 amSTL Lambert-St Louis-SCL Santiago Arturo Merino Benitez

17h 16m2 stops Chicago O'Hare Intl Miami

8:35 pm - 1:15 pmSCL Santiago Arturo Merino Benitez-STL Lambert-St Louis

17h 40m2 stops Miami Chicago O'Hare Intl

$1,170American Airlines

Sun, Jan 10 - Thu, May 6

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United Airlines flights from St. Louis to Santiago

Our best United Airlines deals on St. Louis to Santiago flight tickets

United Airlines

Jan 15

STL3:07 pmLambert-St Louis

14h 43m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Jan 28

SCL10:45 pmSantiago Arturo Merino Benitez

20h 58m

1 stop

STL4:43 pmLambert-St Louis

$1,177

United Airlines

Dec 2

STL3:00 pmLambert-St Louis

14h 50m

1 stop

SCL8:50 amSantiago Arturo Merino Benitez

Dec 4

SCL10:45 pmSantiago Arturo Merino Benitez

18h 31m

1 stop

STL2:16 pmLambert-St Louis

$1,228

United Airlines

Dec 2

STL8:02 amLambert-St Louis

21h 48m

2 stops

SCL8:50 amSantiago Arturo Merino Benitez

Dec 4

SCL10:45 pmSantiago Arturo Merino Benitez

14h 00m

1 stop

STL9:45 amLambert-St Louis

$1,232

LATAM Airlines flights from St. Louis to Santiago

Our best LATAM Airlines deals on St. Louis to Santiago flight tickets

LATAM Airlines

Dec 22

STL3:48 pmLambert-St Louis

11h 52m

1 stop

SCL6:40 amSantiago Arturo Merino Benitez

Jan 8

SCL8:15 amSantiago Arturo Merino Benitez

37h 26m

3 stops

STL6:41 pmLambert-St Louis

$1,057

LATAM Airlines

Dec 29

STL3:48 pmLambert-St Louis

20h 12m

3 stops

SCL3:00 pmSantiago Arturo Merino Benitez

Jan 19

SCL9:45 amSantiago Arturo Merino Benitez

26h 32m

2 stops

STL9:17 amLambert-St Louis

$1,170

LATAM Airlines

Dec 22

STL3:48 pmLambert-St Louis

12h 52m

1 stop

SCL7:40 amSantiago Arturo Merino Benitez

Jan 8

SCL8:15 amSantiago Arturo Merino Benitez

37h 26m

3 stops

STL6:41 pmLambert-St Louis

$1,172

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 11/25

3:04 pm-5:45 am

3 stops35h 41m

Santiago Arturo Merino Benitez

Wed 12/9

4:15 pm-12:12 am

2 stops34h 57m

$742

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 11/25

3:04 pm-5:45 am

3 stops35h 41m

Santiago Arturo Merino Benitez

Wed 12/9

4:15 pm-12:12 am

2 stops34h 57m

$756

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 12/22

3:48 pm-6:40 am

1 stop11h 52m

Santiago Arturo Merino Benitez

Fri 1/8

8:15 am-6:41 pm

3 stops37h 26m

$1,057

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 11/25

1:20 pm-3:38 am

2 stops35h 18m

Santiago Arturo Merino Benitez

Wed 12/9

5:00 am-6:14 pm

1 stop16h 14m

$1,127

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 1/13

3:48 pm-3:00 pm

2 stops20h 12m

Santiago Arturo Merino Benitez

Thu 1/28

11:00 pm-9:17 am

1 stop13h 17m

$1,166

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Thu 1/14

10:12 am-7:40 am

1 stop18h 28m

Santiago Arturo Merino Benitez

Mon 2/1

9:50 pm-9:17 am

1 stop14h 27m

$1,166

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Tue 1/19

12:00 pm-6:40 am

1 stop15h 40m

Santiago Arturo Merino Benitez

Mon 2/1

7:40 am-11:26 pm

2 stops18h 46m

$1,166

Quickest round-trip

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 1/10

3:45 pm-8:35 am

1 stop13h 50m

Santiago Arturo Merino Benitez

Thu 5/6

8:35 pm-9:20 am

1 stop13h 45m

$1,166

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Wed 1/13

6:00 am-6:40 am

1 stop21h 40m

Santiago Arturo Merino Benitez

Wed 1/27

11:00 pm-9:17 am

1 stop13h 17m

$1,166

St. LouisSantiago

STL Lambert-St Louis - SCL Santiago Arturo Merino Benitez

STLSCL

Lambert-St Louis

Sun 1/10

1:49 pm-10:05 am

2 stops17h 16m

Santiago Arturo Merino Benitez

Thu 5/6

8:35 pm-1:15 pm

2 stops17h 40m

$1,170

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between St. Louis and Santiago?

Prices are currently low for flights on this route.

Typical prices usually range from $1,258 to $1,405.
The lowest price recently found on this route was $742.

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from St. Louis to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $995. If you don’t want to visit Santiago in October, then you should wait until March to fly from St. Louis, when ticket prices are also cheap, with an average price of $1,003.

When to book flights from St. Louis to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap St. Louis to Santiago (STL to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago

Best Price Found	$428
Fastest flight time	17h 06m
Direct flights	None

The best one-way flight to Santiago from St. Louis in the past 72 hours is $428. The best round-trip flight deal from St. Louis to Santiago found on momondo in the last 72 hours is $742.

The fastest flight from St. Louis to Santiago takes 17h 06m

There are no direct flights from St. Louis to Santiago. There are no popular flight routes from St. Louis to Santiago.

Search flight deals

Frequently asked questions about flying from St. Louis to Santiago

How far is Lambert-St Louis to Santiago Arturo Merino Benitez by plane?
The distance between Lambert-St Louis and Santiago Arturo Merino Benitez is about 5131.6 mi. Typically, this will take 17h 06m by plane in normal conditions.
When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
As of November 2026, there are 3 operators available to choose from for flights from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Santiago?
Based on momondo bookings for flights between St. Louis and Santiago, the leading airline is Delta, making up 52% of the total bookings. Other popular airlines include LATAM Airlines with 25% and American Airlines with 23%.

Best airlines flying from St. Louis to Santiago

Compare and see reviews for airlines that fly from St. Louis to Santiago with momondo

Airline	Rating	Free Cancellation	Price
LATAM Airlines	PriceFrom $792	Free Cancellation	Rating 7.4 1,972 reviews	Search LATAM Airlines flights
Delta	PriceFrom $858	Free Cancellation	Rating 7.8 8,698 reviews	Search Delta flights
American Airlines	PriceFrom $894	Free Cancellation	Rating 7.0 12,230 reviews	Search American Airlines flights

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Why should I use momondo to find a flight deal from St. Louis to Santiago?

Finding the right flight to Santiago from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago with flexible booking policies on momondo?

Flights from St. Louis to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.