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Cheap flights from South Carolina to Santo Domingo from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 10/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
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Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Spirit Airlines Logo
5:45 am - 2:54 pmCLT-SDQ
9h 09m1 stop
Spirit Airlines Logo
3:59 pm - 11:28 pmSDQ-CLT
7h 29m1 stop
$286Spirit Airlines
Find Deal
Sat, Oct 18 - Sat, Oct 25
Spirit Airlines Logo
5:45 am - 4:07 pmCLT-SDQ
10h 22m1 stop
Spirit Airlines Logo
3:59 pm - 11:28 pmSDQ-CLT
7h 29m1 stop
$299Spirit Airlines
Find Deal
Mon, Oct 13 - Sat, Nov 1
American Airlines Logo
6:00 am - 3:20 pmCHS-SDQ
9h 20m1 stop
American Airlines Logo
10:25 am - 7:04 pmSDQ-CHS
8h 39m1 stop
$315American Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21
Multiple Airlines Logo
1:49 pm - 9:45 pmCLT-SDQ
7h 56m1 stop
Multiple Airlines Logo
3:59 pm - 11:28 pmSDQ-CLT
7h 29m1 stop
$317Multiple Airlines
Find Deal
Sat, Oct 18 - Sat, Oct 25
American Airlines Logo
6:35 am - 8:30 pmCHS-SDQ
13h 55m2 stops
American Airlines Logo
7:00 am - 4:54 pmSDQ-CHS
9h 54m2 stops
$319American Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21
Multiple Airlines Logo
1:49 pm - 9:45 pmCLT-SDQ
7h 56m1 stop
Multiple Airlines Logo
6:55 pm - 9:27 amSDQ-CLT
15h 32m1 stop
$319Multiple Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 10
JetBlue Logo
12:05 pm - 9:24 pmCHS-SDQ
8h 19m1 stop
JetBlue Logo
2:35 am - 11:19 amSDQ-CHS
9h 44m1 stop
$385JetBlue
Find Deal
Tue, Mar 3 - Wed, Mar 4
JetBlue Logo
12:05 pm - 9:24 pmCHS-SDQ
8h 19m1 stop
JetBlue Logo
2:35 am - 11:19 amSDQ-CHS
9h 44m1 stop
$434JetBlue
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
5:36 am - 7:08 pmSAV-SDQ
12h 32m2 stops
Delta Logo
6:45 am - 8:58 pmSDQ-SAV
15h 13m2 stops
$472Delta
Find Deal
Wed, Nov 12 - Wed, Nov 19
Delta Logo
5:32 pm - 1:48 amSAV-SDQ
7h 16m1 stop
Delta Logo
8:40 pm - 11:13 amSDQ-SAV
15h 33m1 stop
$477Delta
Find Deal
Thu, Dec 4 - Thu, Dec 18

Spirit Airlines flights from South Carolina to Santo Domingo

Our best Spirit Airlines deals on South Carolina to Santo Domingo flight tickets
Spirit Airlines
Oct 18
CLT5:45 amCharlotte Douglas
9h 09m
1 stop
SDQ2:54 pmSanto Domingo Las Americas
Oct 25
SDQ3:59 pmSanto Domingo Las Americas
7h 29m
1 stop
CLT11:28 pmCharlotte Douglas
$286
Find similar
Spirit Airlines
Oct 13
CLT5:45 amCharlotte Douglas
10h 22m
1 stop
SDQ4:07 pmSanto Domingo Las Americas
Nov 1
SDQ3:59 pmSanto Domingo Las Americas
7h 29m
1 stop
CLT11:28 pmCharlotte Douglas
$299
Find similar
Spirit Airlines
Dec 6
CLT5:45 amCharlotte Douglas
11h 05m
1 stop
SDQ5:50 pmSanto Domingo Las Americas
Dec 13
SDQ8:01 amSanto Domingo Las Americas
17h 58m
2 stops
CLT12:59 amCharlotte Douglas
$309
Find similar

American Airlines flights from South Carolina to Santo Domingo

Our best American Airlines deals on South Carolina to Santo Domingo flight tickets
American Airlines
Oct 14
CHS6:00 amCharleston
9h 20m
1 stop
SDQ3:20 pmSanto Domingo Las Americas
Oct 21
SDQ10:25 amSanto Domingo Las Americas
8h 39m
1 stop
CHS7:04 pmCharleston
$315
Find similar
American Airlines
Oct 14
CHS6:35 amCharleston
13h 55m
2 stops
SDQ8:30 pmSanto Domingo Las Americas
Oct 21
SDQ7:00 amSanto Domingo Las Americas
9h 54m
2 stops
CHS4:54 pmCharleston
$319
Find similar
American Airlines
Sep 25
CHS7:08 amCharleston
13h 22m
1 stop
SDQ8:30 pmSanto Domingo Las Americas
Sep 30
SDQ4:20 pmSanto Domingo Las Americas
7h 38m
1 stop
CHS11:58 pmCharleston
$323
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 10/18

5:45 am-2:54 pm

1 stop9h 09m

Santo Domingo Las Americas

Sat 10/25

3:59 pm-11:28 pm

1 stop7h 29m

$286

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 10/13

5:45 am-4:07 pm

1 stop10h 22m

Santo Domingo Las Americas

Sat 11/1

3:59 pm-11:28 pm

1 stop7h 29m

$299

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 10/14

6:00 am-3:20 pm

1 stop9h 20m

Santo Domingo Las Americas

Tue 10/21

10:25 am-7:04 pm

1 stop8h 39m

$315

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 10/18

1:49 pm-9:45 pm

1 stop7h 56m

Santo Domingo Las Americas

Sat 10/25

3:59 pm-11:28 pm

1 stop7h 29m

$317

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 10/14

6:35 am-8:30 pm

2 stops13h 55m

Santo Domingo Las Americas

Tue 10/21

7:00 am-4:54 pm

2 stops9h 54m

$319

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 10/30

1:49 pm-9:45 pm

1 stop7h 56m

Santo Domingo Las Americas

Mon 11/10

6:55 pm-9:27 am

1 stop15h 32m

$319

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 3/3

12:05 pm-9:24 pm

1 stop8h 19m

Santo Domingo Las Americas

Wed 3/4

2:35 am-11:19 am

1 stop9h 44m

$385

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 3/3

12:05 pm-9:24 pm

1 stop8h 19m

Santo Domingo Las Americas

Wed 3/4

2:35 am-11:19 am

1 stop9h 44m

$434

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Wed 11/12

5:36 am-7:08 pm

2 stops12h 32m

Santo Domingo Las Americas

Wed 11/19

6:45 am-8:58 pm

2 stops15h 13m

$472

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Thu 12/4

5:32 pm-1:48 am

1 stop7h 16m

Santo Domingo Las Americas

Thu 12/18

8:40 pm-11:13 am

1 stop15h 33m

$477

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until November to fly from South Carolina, when ticket prices are also cheap, with an average price of $440.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $391. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $760.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $257. Try not to purchase tickets in the afternoon because they tend to be around $637. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Direct flights

None
There are no direct flights from South Carolina to Santo Domingo. There are no popular flight routes from South Carolina to Santo Domingo.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $327Free CancellationRating
6.3
8,031 reviews
Search Spirit Airlines flights
DeltaPriceFrom $420Free CancellationRating
7.9
7,971 reviews
Search Delta flights
American AirlinesPriceFrom $420Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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