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Cheap flights from South Carolina to Santo Domingo from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 4/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:54 pm - 1:29 pm
CLT
-
SDQ
15h 35m
1 stop
Spirit Airlines Logo
2:35 pm - 8:49 pm
SDQ
-
CLT
6h 14m
1 stop
$330Spirit Airlines
Sat, Apr 25 - Tue, Apr 28
Frontier Logo
6:18 pm - 1:39 pm
MYR
-
SDQ
19h 21m
1 stop
Frontier Logo
12:21 pm - 11:49 am
SDQ
-
MYR
23h 28m
1 stop
$331Frontier
Sat, May 23 - Fri, Jun 19
Multiple Airlines Logo
9:54 pm - 1:29 pm
CLT
-
SDQ
15h 35m
1 stop
Multiple Airlines Logo
12:10 pm - 4:55 pm
SDQ
-
CLT
28h 45m
1 stop
$362Multiple Airlines
Thu, Apr 30 - Fri, May 8
Multiple Airlines Logo
8:56 am - 1:29 pm
CLT
-
SDQ
28h 33m
1 stop
Multiple Airlines Logo
12:41 pm - 7:13 pm
SDQ
-
CLT
30h 32m
2 stops
$363Multiple Airlines
Mon, Apr 27 - Mon, May 4
Delta Logo
6:00 am - 6:34 pm
CHS
-
SDQ
12h 34m
1 stop
Delta Logo
6:05 am - 8:46 pm
SDQ
-
CHS
14h 41m
1 stop
$380Delta
Sat, May 2 - Sat, May 9
American Airlines Logo
6:20 pm - 9:20 am
CHS
-
SDQ
15h 00m
2 stops
American Airlines Logo
2:25 pm - 12:24 am
SDQ
-
CHS
9h 59m
1 stop
$385American Airlines
Sat, May 2 - Sat, May 9
American Airlines Logo
6:20 pm - 9:20 am
CHS
-
SDQ
15h 00m
2 stops
American Airlines Logo
5:55 pm - 12:24 am
SDQ
-
CHS
6h 29m
1 stop
$390American Airlines
Sat, May 2 - Sun, May 10
JetBlue Logo
10:07 am - 12:20 am
CHS
-
SDQ
14h 13m
1 stop
JetBlue Logo
5:01 am - 6:02 pm
SDQ
-
CHS
13h 01m
1 stop
$409JetBlue
Tue, Jun 9 - Sun, Jun 14
JetBlue Logo
10:42 am - 6:20 pm
SAV
-
SDQ
7h 38m
1 stop
JetBlue Logo
8:32 pm - 9:51 am
SDQ
-
SAV
13h 19m
1 stop
$416JetBlue
Tue, May 5 - Mon, May 18
Delta Logo
1:03 pm - 12:41 am
CHS
-
SDQ
11h 38m
1 stop
Delta Logo
7:35 pm - 10:18 am
SDQ
-
CHS
14h 43m
2 stops
$425Delta
Thu, Jun 4 - Thu, Jun 11

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Frontier flights from South Carolina to Santo Domingo

Our best Frontier deals on South Carolina to Santo Domingo flight tickets
Frontier
May 23
MYR6:18 pmMyrtle Beach Intl
19h 21m
1 stop
SDQ1:39 pmSanto Domingo Las Americas
Jun 19
SDQ12:21 pmSanto Domingo Las Americas
23h 28m
1 stop
MYR11:49 amMyrtle Beach Intl
$331
Frontier
May 22
CLT1:00 pmCharlotte Douglas
24h 39m
1 stop
SDQ1:39 pmSanto Domingo Las Americas
May 24
SDQ2:44 pmSanto Domingo Las Americas
19h 19m
1 stop
CLT10:03 amCharlotte Douglas
$351
Frontier
May 7
CLT1:00 pmCharlotte Douglas
22h 05m
1 stop
SDQ11:05 amSanto Domingo Las Americas
May 31
SDQ2:44 pmSanto Domingo Las Americas
19h 19m
1 stop
CLT10:03 amCharlotte Douglas
$375

Delta flights from South Carolina to Santo Domingo

Our best Delta deals on South Carolina to Santo Domingo flight tickets
Delta
May 2
CHS6:00 amCharleston
12h 34m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
May 9
SDQ6:05 amSanto Domingo Las Americas
14h 41m
1 stop
CHS8:46 pmCharleston
$380
Delta
Apr 22
CHS12:25 pmCharleston
11h 52m
2 stops
SDQ12:17 amSanto Domingo Las Americas
Apr 25
SDQ6:05 amSanto Domingo Las Americas
11h 01m
1 stop
CHS5:06 pmCharleston
$385
Delta
Jun 4
CHS1:03 pmCharleston
11h 38m
1 stop
SDQ12:41 amSanto Domingo Las Americas
Jun 11
SDQ7:35 pmSanto Domingo Las Americas
14h 43m
2 stops
CHS10:18 amCharleston
$425

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 4/25

9:54 pm-1:29 pm

1 stop15h 35m

Santo Domingo Las Americas

Tue 4/28

2:35 pm-8:49 pm

1 stop6h 14m

$330

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 5/23

6:18 pm-1:39 pm

1 stop19h 21m

Santo Domingo Las Americas

Fri 6/19

12:21 pm-11:49 am

1 stop23h 28m

$331

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 4/30

9:54 pm-1:29 pm

1 stop15h 35m

Santo Domingo Las Americas

Fri 5/8

12:10 pm-4:55 pm

1 stop28h 45m

$362

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 4/27

8:56 am-1:29 pm

1 stop28h 33m

Santo Domingo Las Americas

Mon 5/4

12:41 pm-7:13 pm

2 stops30h 32m

$363

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/2

6:00 am-6:34 pm

1 stop12h 34m

Santo Domingo Las Americas

Sat 5/9

6:05 am-8:46 pm

1 stop14h 41m

$380

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/2

6:20 pm-9:20 am

2 stops15h 00m

Santo Domingo Las Americas

Sat 5/9

2:25 pm-12:24 am

1 stop9h 59m

$385

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/2

6:20 pm-9:20 am

2 stops15h 00m

Santo Domingo Las Americas

Sun 5/10

5:55 pm-12:24 am

1 stop6h 29m

$390

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/9

10:07 am-12:20 am

1 stop14h 13m

Santo Domingo Las Americas

Sun 6/14

5:01 am-6:02 pm

1 stop13h 01m

$409
Quickest round-trip

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Tue 5/5

10:42 am-6:20 pm

1 stop7h 38m

Santo Domingo Las Americas

Mon 5/18

8:32 pm-9:51 am

1 stop13h 19m

$416

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 6/4

1:03 pm-12:41 am

1 stop11h 38m

Santo Domingo Las Americas

Thu 6/11

7:35 pm-10:18 am

2 stops14h 43m

$425

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from South Carolina, when ticket prices are also cheap, with an average price of $398.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Fastest flight time

5h 47m

Direct flights

None
The fastest flight from South Carolina to Santo Domingo takes 5h 47m
There are no direct flights from South Carolina to Santo Domingo. There are no popular flight routes from South Carolina to Santo Domingo.
Search flight deals

Frequently asked questions about flying from South Carolina to Santo Domingo

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.9
8,404 reviews
Search Delta flights
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,580 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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