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Cheap flights from South Carolina to Santo Domingo from $167

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 7/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
5:27 pm - 11:59 pm
CHS
-
SDQ
6h 32m
1 stop
JetBlue Logo
5:01 am - 4:47 pm
SDQ
-
CHS
11h 46m
1 stop
$363JetBlue
Thu, Aug 20 - Mon, Aug 24
JetBlue Logo
9:00 am - 3:21 pm
CLT
-
SDQ
6h 21m
1 stop
JetBlue Logo
5:01 am - 2:15 pm
SDQ
-
CLT
9h 14m
1 stop
$363JetBlue
Tue, Sep 1 - Tue, Sep 8
Delta Logo
6:00 am - 6:04 pm
CHS
-
SDQ
12h 04m
1 stop
Delta Logo
6:06 am - 4:54 pm
SDQ
-
CHS
10h 48m
1 stop
$368Delta
Fri, Jun 12 - Wed, Jun 17
American Airlines Logo
7:48 pm - 1:22 pm
CHS
-
SDQ
17h 34m
2 stops
American Airlines Logo
2:22 pm - 11:59 pm
SDQ
-
CHS
9h 37m
1 stop
$373American Airlines
Thu, Aug 20 - Mon, Aug 24
American Airlines Logo
5:13 pm - 1:22 pm
CHS
-
SDQ
20h 09m
1 stop
American Airlines Logo
4:24 pm - 1:16 pm
SDQ
-
CHS
20h 52m
2 stops
$380American Airlines
Fri, Aug 21 - Tue, Aug 25
Delta Logo
5:10 am - 1:16 pm
CHS
-
SDQ
8h 06m
1 stop
Delta Logo
6:06 am - 4:54 pm
SDQ
-
CHS
10h 48m
1 stop
$388Delta
Fri, Jun 12 - Wed, Jun 17
Frontier Logo
1:09 pm - 11:06 am
CLT
-
SDQ
21h 57m
1 stop
Frontier Logo
12:18 pm - 9:56 am
SDQ
-
CLT
21h 38m
1 stop
$405Frontier
Wed, Jul 1 - Wed, Jul 15
Multiple Airlines Logo
1:09 pm - 11:06 am
CLT
-
SDQ
21h 57m
1 stop
Multiple Airlines Logo
7:00 am - 2:15 pm
SDQ
-
CLT
7h 15m
1 stop
$410Multiple Airlines
Wed, Jul 1 - Sat, Jul 11
Multiple Airlines Logo
10:02 pm - 11:03 am
CLT
-
SDQ
13h 01m
1 stop
Multiple Airlines Logo
7:00 am - 2:15 pm
SDQ
-
CLT
7h 15m
1 stop
$419Multiple Airlines
Sun, Jul 5 - Sat, Jul 25
Frontier Logo
6:28 pm - 11:06 am
MYR
-
SDQ
16h 38m
1 stop
Frontier Logo
12:03 pm - 11:43 am
SDQ
-
MYR
47h 40m
2 stops
$594Frontier
Sun, Jun 28 - Sun, Jul 5

JetBlue flights from South Carolina to Santo Domingo

Our best JetBlue deals on South Carolina to Santo Domingo flight tickets
JetBlue
Aug 20
CHS5:27 pmCharleston
6h 32m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Aug 24
SDQ5:01 amSanto Domingo Las Americas
11h 46m
1 stop
CHS4:47 pmCharleston
$363
JetBlue
Aug 25
CLT9:00 amCharlotte Douglas
6h 21m
1 stop
SDQ3:21 pmSanto Domingo Las Americas
Aug 26
SDQ5:01 amSanto Domingo Las Americas
9h 14m
1 stop
CLT2:15 pmCharlotte Douglas
$368
JetBlue
Aug 3
CLT3:10 pmCharlotte Douglas
8h 49m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Aug 15
SDQ5:01 amSanto Domingo Las Americas
9h 14m
1 stop
CLT2:15 pmCharlotte Douglas
$392

American Airlines flights from South Carolina to Santo Domingo

Our best American Airlines deals on South Carolina to Santo Domingo flight tickets
American Airlines
Aug 20
CHS7:48 pmCharleston
17h 34m
2 stops
SDQ1:22 pmSanto Domingo Las Americas
Aug 24
SDQ2:22 pmSanto Domingo Las Americas
9h 37m
1 stop
CHS11:59 pmCharleston
$373
American Airlines
Aug 21
CHS5:13 pmCharleston
20h 09m
1 stop
SDQ1:22 pmSanto Domingo Las Americas
Aug 25
SDQ4:24 pmSanto Domingo Las Americas
20h 52m
2 stops
CHS1:16 pmCharleston
$380
American Airlines
Aug 20
CHS7:30 amCharleston
11h 14m
2 stops
SDQ6:44 pmSanto Domingo Las Americas
Aug 24
SDQ10:27 amSanto Domingo Las Americas
13h 32m
1 stop
CHS11:59 pmCharleston
$393

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 2, 2026.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 8/20

5:27 pm-11:59 pm

1 stop6h 32m

Santo Domingo Las Americas

Mon 8/24

5:01 am-4:47 pm

1 stop11h 46m

$363
Quickest round-trip

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 9/1

9:00 am-3:21 pm

1 stop6h 21m

Santo Domingo Las Americas

Tue 9/8

5:01 am-2:15 pm

1 stop9h 14m

$363

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 6/12

6:00 am-6:04 pm

1 stop12h 04m

Santo Domingo Las Americas

Wed 6/17

6:06 am-4:54 pm

1 stop10h 48m

$368

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 8/20

7:48 pm-1:22 pm

2 stops17h 34m

Santo Domingo Las Americas

Mon 8/24

2:22 pm-11:59 pm

1 stop9h 37m

$373

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 8/21

5:13 pm-1:22 pm

1 stop20h 09m

Santo Domingo Las Americas

Tue 8/25

4:24 pm-1:16 pm

2 stops20h 52m

$380

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 6/12

5:10 am-1:16 pm

1 stop8h 06m

Santo Domingo Las Americas

Wed 6/17

6:06 am-4:54 pm

1 stop10h 48m

$388

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 7/1

1:09 pm-11:06 am

1 stop21h 57m

Santo Domingo Las Americas

Wed 7/15

12:18 pm-9:56 am

1 stop21h 38m

$405

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 7/1

1:09 pm-11:06 am

1 stop21h 57m

Santo Domingo Las Americas

Sat 7/11

7:00 am-2:15 pm

1 stop7h 15m

$410

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sun 7/5

10:02 pm-11:03 am

1 stop13h 01m

Santo Domingo Las Americas

Sat 7/25

7:00 am-2:15 pm

1 stop7h 15m

$419

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 6/28

6:28 pm-11:06 am

1 stop16h 38m

Santo Domingo Las Americas

Sun 7/5

12:03 pm-11:43 am

2 stops47h 40m

$594

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until January to fly from South Carolina, when ticket prices are also cheap, with an average price of $317.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from South Carolina to Santo Domingo takes 4h 54m
There are no direct flights from South Carolina to Santo Domingo. There are no popular flight routes from South Carolina to Santo Domingo.
Search flight deals

Frequently asked questions about flying from South Carolina to Santo Domingo

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights
DeltaPriceFrom $499Free CancellationRating
7.9
8,397 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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