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Cheap flights from South Carolina to Santo Domingo from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
8:00 am - 2:40 pm
CLT
-
SDQ
5h 40m
1 stop
Delta Logo
3:55 pm - 11:53 pm
SDQ
-
CLT
8h 58m
1 stop
$410Delta
Wed, Nov 18 - Wed, Nov 25
Delta Logo
1:15 pm - 1:35 am
CLT
-
SDQ
11h 20m
1 stop
Delta Logo
3:55 pm - 9:33 pm
SDQ
-
CLT
6h 38m
1 stop
$412Delta
Wed, Nov 18 - Wed, Nov 25
Delta Logo
12:59 pm - 1:35 am
CLT
-
SDQ
11h 36m
2 stops
Delta Logo
3:55 pm - 9:33 pm
SDQ
-
CLT
6h 38m
1 stop
$415Delta
Wed, Nov 18 - Wed, Nov 25
Delta Logo
12:59 pm - 1:35 am
CLT
-
SDQ
11h 36m
2 stops
Delta Logo
3:55 pm - 9:33 pm
SDQ
-
CLT
6h 38m
1 stop
$417Delta
Wed, Nov 18 - Wed, Nov 25
Delta Logo
5:30 am - 1:28 pm
CLT
-
SDQ
7h 58m
1 stop
Delta Logo
2:53 pm - 9:58 pm
SDQ
-
CLT
7h 05m
1 stop
$420Delta
Sun, Aug 23 - Thu, Aug 27
Delta Logo
5:30 am - 1:27 pm
CLT
-
SDQ
7h 57m
1 stop
Delta Logo
2:53 pm - 9:31 pm
SDQ
-
CLT
6h 38m
1 stop
$421Delta
Mon, Sep 28 - Mon, Oct 5
American Airlines Logo
5:20 am - 3:24 pm
CLT
-
SDQ
10h 04m
1 stop
American Airlines Logo
2:22 pm - 10:20 am
SDQ
-
CLT
19h 58m
1 stop
$425American Airlines
Tue, Sep 1 - Tue, Sep 8
American Airlines Logo
9:06 am - 6:34 pm
CLT
-
SDQ
9h 28m
1 stop
American Airlines Logo
7:34 pm - 8:25 am
SDQ
-
CLT
12h 51m
1 stop
$426American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
6:00 am - 6:44 pm
CHS
-
SDQ
12h 44m
1 stop
American Airlines Logo
10:27 am - 11:59 pm
SDQ
-
CHS
13h 32m
1 stop
$428American Airlines
Thu, Aug 20 - Mon, Aug 24
Frontier Logo
6:23 pm - 11:03 am
MYR
-
SDQ
16h 40m
1 stop
Frontier Logo
12:18 pm - 11:43 am
SDQ
-
MYR
23h 25m
1 stop
$530Frontier
Sun, Aug 2 - Sat, Aug 8

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Delta flights from South Carolina to Santo Domingo

Our best Delta deals on South Carolina to Santo Domingo flight tickets
Delta
Nov 18
CLT8:00 amCharlotte Douglas
5h 40m
1 stop
SDQ2:40 pmSanto Domingo Las Americas
Nov 25
SDQ3:55 pmSanto Domingo Las Americas
8h 58m
1 stop
CLT11:53 pmCharlotte Douglas
$410
Delta
Nov 18
CLT1:15 pmCharlotte Douglas
11h 20m
1 stop
SDQ1:35 amSanto Domingo Las Americas
Nov 25
SDQ3:55 pmSanto Domingo Las Americas
6h 38m
1 stop
CLT9:33 pmCharlotte Douglas
$412
Delta
Nov 18
CLT12:59 pmCharlotte Douglas
11h 36m
2 stops
SDQ1:35 amSanto Domingo Las Americas
Nov 25
SDQ3:55 pmSanto Domingo Las Americas
6h 38m
1 stop
CLT9:33 pmCharlotte Douglas
$415

American Airlines flights from South Carolina to Santo Domingo

Our best American Airlines deals on South Carolina to Santo Domingo flight tickets
American Airlines
Sep 1
CLT5:20 amCharlotte Douglas
10h 04m
1 stop
SDQ3:24 pmSanto Domingo Las Americas
Sep 8
SDQ2:22 pmSanto Domingo Las Americas
19h 58m
1 stop
CLT10:20 amCharlotte Douglas
$425
American Airlines
Oct 1
CLT9:06 amCharlotte Douglas
9h 28m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
Oct 4
SDQ7:34 pmSanto Domingo Las Americas
12h 51m
1 stop
CLT8:25 amCharlotte Douglas
$426
American Airlines
Aug 20
CHS6:00 amCharleston
12h 44m
1 stop
SDQ6:44 pmSanto Domingo Las Americas
Aug 24
SDQ10:27 amSanto Domingo Las Americas
13h 32m
1 stop
CHS11:59 pmCharleston
$428

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 22, 2026.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 11/18

8:00 am-2:40 pm

1 stop5h 40m

Santo Domingo Las Americas

Wed 11/25

3:55 pm-11:53 pm

1 stop8h 58m

$410

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 11/18

1:15 pm-1:35 am

1 stop11h 20m

Santo Domingo Las Americas

Wed 11/25

3:55 pm-9:33 pm

1 stop6h 38m

$412

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 11/18

12:59 pm-1:35 am

2 stops11h 36m

Santo Domingo Las Americas

Wed 11/25

3:55 pm-9:33 pm

1 stop6h 38m

$415

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 11/18

12:59 pm-1:35 am

2 stops11h 36m

Santo Domingo Las Americas

Wed 11/25

3:55 pm-9:33 pm

1 stop6h 38m

$417

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sun 8/23

5:30 am-1:28 pm

1 stop7h 58m

Santo Domingo Las Americas

Thu 8/27

2:53 pm-9:58 pm

1 stop7h 05m

$420
Quickest round-trip

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 9/28

5:30 am-1:27 pm

1 stop7h 57m

Santo Domingo Las Americas

Mon 10/5

2:53 pm-9:31 pm

1 stop6h 38m

$421

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 9/1

5:20 am-3:24 pm

1 stop10h 04m

Santo Domingo Las Americas

Tue 9/8

2:22 pm-10:20 am

1 stop19h 58m

$425

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 10/1

9:06 am-6:34 pm

1 stop9h 28m

Santo Domingo Las Americas

Sun 10/4

7:34 pm-8:25 am

1 stop12h 51m

$426

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 8/20

6:00 am-6:44 pm

1 stop12h 44m

Santo Domingo Las Americas

Mon 8/24

10:27 am-11:59 pm

1 stop13h 32m

$428

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 8/2

6:23 pm-11:03 am

1 stop16h 40m

Santo Domingo Las Americas

Sat 8/8

12:18 pm-11:43 am

1 stop23h 25m

$530

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until October to fly from South Carolina, when ticket prices are also cheap, with an average price of $468.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from South Carolina to Santo Domingo takes 4h 54m
There are no direct flights from South Carolina to Santo Domingo. There are no popular flight routes from South Carolina to Santo Domingo.
Search flight deals

Frequently asked questions about flying from South Carolina to Santo Domingo

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.8
8,473 reviews
Search Delta flights
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,832 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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