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Cheap flights from South Carolina to Santo Domingo from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 9/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Spirit Airlines Logo
6:00 am - 2:56 pmCLT-SDQ
8h 56m1 stop
Spirit Airlines Logo
4:01 pm - 9:22 amSDQ-CLT
17h 21m1 stop
$296Spirit Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
Spirit Airlines Logo
5:45 am - 4:00 pmCLT-SDQ
10h 15m1 stop
Spirit Airlines Logo
5:05 pm - 9:22 amSDQ-CLT
16h 17m1 stop
$301Spirit Airlines
Find Deal
Thu, Sep 18 - Sun, Sep 21
Logo
9:45 am - 5:50 pmSAV-SDQ
7h 05m1 stop
Logo
6:55 pm - 10:15 amSDQ-SAV
16h 20m1 stop
$340
Find Deal
Mon, Nov 17 - Wed, Nov 19
Logo
6:00 am - 3:55 pmCLT-SDQ
9h 55m1 stop
Logo
3:35 pm - 12:23 pmSDQ-CLT
21h 48m1 stop
$356
Find Deal
Mon, Oct 27 - Sun, Nov 2
JetBlue Logo
11:10 am - 12:59 amCHS-SDQ
13h 49m1 stop
JetBlue Logo
6:05 pm - 10:25 amSDQ-CHS
16h 20m1 stop
$403JetBlue
Find Deal
Tue, Sep 16 - Fri, Sep 26
JetBlue Logo
11:10 am - 9:04 amCHS-SDQ
21h 54m2 stops
JetBlue Logo
6:05 pm - 10:25 amSDQ-CHS
16h 20m1 stop
$404JetBlue
Find Deal
Tue, Sep 16 - Fri, Sep 26
Delta Logo
6:20 am - 1:22 pmCHS-SDQ
7h 02m1 stop
Delta Logo
6:00 am - 6:57 pmSDQ-CHS
12h 57m2 stops
$445Delta
Find Deal
Tue, Sep 2 - Tue, Sep 9
American Airlines Logo
6:00 am - 8:30 pmCHS-SDQ
14h 30m2 stops
American Airlines Logo
7:00 am - 8:55 pmSDQ-CHS
13h 55m2 stops
$450American Airlines
Find Deal
Wed, Sep 17 - Sun, Sep 28
Delta Logo
5:30 am - 1:41 pmGSP-SDQ
8h 11m1 stop
Delta Logo
3:56 pm - 11:54 pmSDQ-GSP
8h 58m1 stop
$465Delta
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Wed, Oct 29 - Wed, Nov 5
American Airlines Logo
7:39 am - 8:30 pmGSP-SDQ
12h 51m2 stops
American Airlines Logo
4:20 pm - 9:53 amSDQ-GSP
17h 33m2 stops
$484American Airlines
Find Deal
Tue, Sep 23 - Sun, Sep 28

Delta flights from South Carolina to Santo Domingo

Our best Delta deals on South Carolina to Santo Domingo flight tickets
Delta
Sep 2
CHS6:20 amCharleston
7h 02m
1 stop
SDQ1:22 pmSanto Domingo Las Americas
Sep 9
SDQ6:00 amSanto Domingo Las Americas
12h 57m
2 stops
CHS6:57 pmCharleston
$445
Find similar
Delta
Oct 29
GSP5:30 amGreenville
8h 11m
1 stop
SDQ1:41 pmSanto Domingo Las Americas
Nov 5
SDQ3:56 pmSanto Domingo Las Americas
8h 58m
1 stop
GSP11:54 pmGreenville
$465
Find similar
Delta
Oct 29
GSP6:35 amGreenville
11h 17m
2 stops
SDQ5:52 pmSanto Domingo Las Americas
Nov 5
SDQ3:56 pmSanto Domingo Las Americas
8h 58m
1 stop
GSP11:54 pmGreenville
$469
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JetBlue flights from South Carolina to Santo Domingo

Our best JetBlue deals on South Carolina to Santo Domingo flight tickets
JetBlue
Sep 16
CHS11:10 amCharleston
13h 49m
1 stop
SDQ12:59 amSanto Domingo Las Americas
Sep 26
SDQ6:05 pmSanto Domingo Las Americas
16h 20m
1 stop
CHS10:25 amCharleston
$403
Find similar
JetBlue
Sep 16
CHS11:10 amCharleston
21h 54m
2 stops
SDQ9:04 amSanto Domingo Las Americas
Sep 26
SDQ6:05 pmSanto Domingo Las Americas
16h 20m
1 stop
CHS10:25 amCharleston
$404
Find similar
JetBlue
Sep 25
CHS9:40 amCharleston
27h 44m
1 stop
SDQ1:24 pmSanto Domingo Las Americas
Sep 29
SDQ6:05 pmSanto Domingo Las Americas
16h 20m
1 stop
CHS10:25 amCharleston
$410
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 10/21

6:00 am-2:56 pm

1 stop8h 56m

Santo Domingo Las Americas

Tue 10/28

4:01 pm-9:22 am

1 stop17h 21m

$296

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 9/18

5:45 am-4:00 pm

1 stop10h 15m

Santo Domingo Las Americas

Sun 9/21

5:05 pm-9:22 am

1 stop16h 17m

$301

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Mon 11/17

9:45 am-5:50 pm

1 stop7h 05m

Santo Domingo Las Americas

Wed 11/19

6:55 pm-10:15 am

1 stop16h 20m

$340

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 10/27

6:00 am-3:55 pm

1 stop9h 55m

Santo Domingo Las Americas

Sun 11/2

3:35 pm-12:23 pm

1 stop21h 48m

$356

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 9/16

11:10 am-12:59 am

1 stop13h 49m

Santo Domingo Las Americas

Fri 9/26

6:05 pm-10:25 am

1 stop16h 20m

$403

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 9/16

11:10 am-9:04 am

2 stops21h 54m

Santo Domingo Las Americas

Fri 9/26

6:05 pm-10:25 am

1 stop16h 20m

$404

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 9/2

6:20 am-1:22 pm

1 stop7h 02m

Santo Domingo Las Americas

Tue 9/9

6:00 am-6:57 pm

2 stops12h 57m

$445

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 9/17

6:00 am-8:30 pm

2 stops14h 30m

Santo Domingo Las Americas

Sun 9/28

7:00 am-8:55 pm

2 stops13h 55m

$450

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 10/29

5:30 am-1:41 pm

1 stop8h 11m

Santo Domingo Las Americas

Wed 11/5

3:56 pm-11:54 pm

1 stop8h 58m

$465

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 9/23

7:39 am-8:30 pm

2 stops12h 51m

Santo Domingo Las Americas

Sun 9/28

4:20 pm-9:53 am

2 stops17h 33m

$484

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until January to fly from South Carolina, when ticket prices are also cheap, with an average price of $463.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $391. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $760.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $257. Try not to purchase tickets in the afternoon because they tend to be around $637. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 1% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Best Price Found

$146

Fastest flight time

5h 30m

Direct flights

None

Airports in Santo Domingo

1 airport
The best one-way flight to Santo Domingo from South Carolina in the past 72 hours is $146. The best round-trip flight deal from South Carolina to Santo Domingo found on momondo in the last 72 hours is $296.
The fastest flight from South Carolina to Santo Domingo takes 5h 30m
There are no direct flights from South Carolina to Santo Domingo. Popular non-direct routes for this connection are Myrtle Beach Intl Airport - Santo Domingo Las Americas Airport, Charlotte Douglas Airport - Santo Domingo Las Americas Airport and Savannah/Hilton Head Airport - Santo Domingo Las Americas Airport.
There is 1 airport near Santo Domingo: Santo Domingo Las Americas (SDQ)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $327Free CancellationRating
6.3
8,055 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $420Free CancellationRating
8.0
7,985 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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