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Cheap flights from South Carolina to Santo Domingo from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santo Domingo departing on 3/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
1:20 pm - 1:38 am
CLT
-
SDQ
12h 18m
1 stop
Spirit Airlines Logo
2:20 pm - 12:38 am
SDQ
-
CLT
10h 18m
1 stop
$260Spirit Airlines
Tue, Mar 24 - Tue, Mar 31
Spirit Airlines Logo
1:20 pm - 1:38 am
CLT
-
SDQ
12h 18m
1 stop
Spirit Airlines Logo
2:20 pm - 8:17 pm
SDQ
-
CLT
5h 57m
1 stop
$266Spirit Airlines
Sat, Mar 28 - Wed, Apr 1
Spirit Airlines Logo
9:00 pm - 1:15 pm
CLT
-
SDQ
16h 15m
1 stop
Spirit Airlines Logo
2:20 pm - 8:17 pm
SDQ
-
CLT
5h 57m
1 stop
$270Spirit Airlines
Mon, Mar 16 - Thu, Mar 19
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
12:12 pm - 9:49 pm
SDQ
-
CHS
9h 37m
1 stop
$272Spirit Airlines
Mon, Apr 13 - Sat, Apr 18
Multiple Airlines Logo
7:00 am - 4:29 pm
CLT
-
SDQ
9h 29m
1 stop
Multiple Airlines Logo
3:44 pm - 10:33 pm
SDQ
-
CLT
6h 49m
1 stop
$296Multiple Airlines
Wed, Apr 1 - Wed, Apr 15
Multiple Airlines Logo
4:50 pm - 5:13 am
SAV
-
SDQ
12h 23m
1 stop
Multiple Airlines Logo
2:52 am - 5:10 pm
SDQ
-
SAV
14h 18m
1 stop
$317Multiple Airlines
Sat, Mar 21 - Thu, Mar 26
American Airlines Logo
6:00 am - 2:59 pm
CHS
-
SDQ
8h 59m
1 stop
American Airlines Logo
5:55 pm - 12:24 am
SDQ
-
CHS
6h 29m
1 stop
$333American Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
8:21 pm - 1:18 pm
CHS
-
SDQ
16h 57m
2 stops
American Airlines Logo
5:55 pm - 12:24 am
SDQ
-
CHS
6h 29m
1 stop
$337American Airlines
Wed, Apr 22 - Sat, Apr 25
JetBlue Logo
10:45 am - 6:20 pm
SAV
-
SDQ
7h 35m
1 stop
JetBlue Logo
7:30 pm - 9:55 am
SDQ
-
SAV
14h 25m
1 stop
$391JetBlue
Thu, Apr 23 - Mon, Apr 27
JetBlue Logo
10:45 am - 12:28 pm
SAV
-
SDQ
25h 43m
2 stops
JetBlue Logo
7:30 pm - 9:55 am
SDQ
-
SAV
14h 25m
1 stop
$416JetBlue
Thu, Apr 23 - Mon, Apr 27

JetBlue flights from South Carolina to Santo Domingo

Our best JetBlue deals on South Carolina to Santo Domingo flight tickets
JetBlue
Apr 23
SAV10:45 amSavannah/Hilton Head
7h 35m
1 stop
SDQ6:20 pmSanto Domingo Las Americas
Apr 27
SDQ7:30 pmSanto Domingo Las Americas
14h 25m
1 stop
SAV9:55 amSavannah/Hilton Head
$391
JetBlue
May 21
CHS10:39 amCharleston
6h 54m
1 stop
SDQ5:33 pmSanto Domingo Las Americas
May 25
SDQ6:47 pmSanto Domingo Las Americas
15h 02m
1 stop
CHS9:49 amCharleston
$401
JetBlue
Apr 23
SAV10:45 amSavannah/Hilton Head
25h 43m
2 stops
SDQ12:28 pmSanto Domingo Las Americas
Apr 27
SDQ7:30 pmSanto Domingo Las Americas
14h 25m
1 stop
SAV9:55 amSavannah/Hilton Head
$416

Delta flights from South Carolina to Santo Domingo

Our best Delta deals on South Carolina to Santo Domingo flight tickets
Delta
Mar 6
CHS5:27 amCharleston
7h 50m
1 stop
SDQ2:17 pmSanto Domingo Las Americas
Mar 8
SDQ6:35 amSanto Domingo Las Americas
10h 34m
1 stop
CHS5:09 pmCharleston
$345
Delta
Apr 22
CHS6:00 amCharleston
12h 34m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
Apr 27
SDQ2:37 pmSanto Domingo Las Americas
8h 25m
1 stop
CHS11:02 pmCharleston
$396
Delta
Apr 27
CHS5:20 amCharleston
13h 14m
2 stops
SDQ6:34 pmSanto Domingo Las Americas
May 2
SDQ6:05 amSanto Domingo Las Americas
12h 47m
2 stops
CHS6:52 pmCharleston
$400

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 3/24

1:20 pm-1:38 am

1 stop12h 18m

Santo Domingo Las Americas

Tue 3/31

2:20 pm-12:38 am

1 stop10h 18m

$260

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 3/28

1:20 pm-1:38 am

1 stop12h 18m

Santo Domingo Las Americas

Wed 4/1

2:20 pm-8:17 pm

1 stop5h 57m

$266

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 3/16

9:00 pm-1:15 pm

1 stop16h 15m

Santo Domingo Las Americas

Thu 3/19

2:20 pm-8:17 pm

1 stop5h 57m

$270

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 4/13

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Sat 4/18

12:12 pm-9:49 pm

1 stop9h 37m

$272

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 4/1

7:00 am-4:29 pm

1 stop9h 29m

Santo Domingo Las Americas

Wed 4/15

3:44 pm-10:33 pm

1 stop6h 49m

$296

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Sat 3/21

4:50 pm-5:13 am

1 stop12h 23m

Santo Domingo Las Americas

Thu 3/26

2:52 am-5:10 pm

1 stop14h 18m

$317

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

6:00 am-2:59 pm

1 stop8h 59m

Santo Domingo Las Americas

Sat 4/25

5:55 pm-12:24 am

1 stop6h 29m

$333

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

8:21 pm-1:18 pm

2 stops16h 57m

Santo Domingo Las Americas

Sat 4/25

5:55 pm-12:24 am

1 stop6h 29m

$337

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Thu 4/23

10:45 am-6:20 pm

1 stop7h 35m

Santo Domingo Las Americas

Mon 4/27

7:30 pm-9:55 am

1 stop14h 25m

$391

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Thu 4/23

10:45 am-12:28 pm

2 stops25h 43m

Santo Domingo Las Americas

Mon 4/27

7:30 pm-9:55 am

1 stop14h 25m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from South Carolina to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from South Carolina, when ticket prices are also cheap, with an average price of $398.

Can stopping save me money on South Carolina to Santo Domingo flights?

You could potentially save up to 30% on your flight if you consider stops on a South Carolina to Santo Domingo flight.

Cheap South Carolina to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santo Domingo

Fastest flight time

6h 25m

Direct flights

None
The fastest flight from South Carolina to Santo Domingo takes 6h 25m
There are no direct flights from South Carolina to Santo Domingo. There are no popular flight routes from South Carolina to Santo Domingo.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santo Domingo Las Americas Airport?

    Prices for flights from South Carolina to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from South Carolina to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santo Domingo

Compare and see reviews for airlines that fly from South Carolina to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.9
8,237 reviews
Search Delta flights
American AirlinesPriceFrom $333Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santo Domingo?

It is quick and easy to find South Carolina to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from South Carolina to Santo Domingo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Santo Domingo flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from South Carolina.

I’m not ready to book a flight from South Carolina to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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