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Cheap flights from San Francisco to Santo Domingo from $215

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

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JetBlue Logo
12:15 pm - 4:34 amSFO-SDQ
12h 19m1 stop
JetBlue Logo
6:00 am - 7:15 pmSDQ-SFO
17h 15m1 stop
$438JetBlue
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Fri, Feb 6 - Tue, Feb 10
JetBlue Logo
9:30 pm - 2:04 pmSFO-SDQ
13h 34m1 stop
JetBlue Logo
3:07 am - 5:35 pmSDQ-SFO
17h 28m1 stop
$446JetBlue
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Thu, Apr 30 - Sun, May 3
JetBlue Logo
8:45 pm - 2:13 pmSFO-SDQ
13h 28m1 stop
JetBlue Logo
6:00 am - 7:15 pmSDQ-SFO
17h 15m1 stop
$454JetBlue
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Fri, Jan 23 - Mon, Feb 9
Copa Airlines Logo
12:36 am - 2:26 amSFO-SDQ
21h 50m1 stop
Copa Airlines Logo
12:40 pm - 11:17 pmSDQ-SFO
14h 37m1 stop
$456Copa Airlines
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Sun, Dec 7 - Wed, Dec 24
Multiple Airlines Logo
11:20 pm - 3:07 pmSFO-SDQ
11h 47m1 stop
Multiple Airlines Logo
4:40 pm - 7:48 amSDQ-SFO
19h 08m2 stops
$473Multiple Airlines
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Sat, Jan 17 - Sat, Jan 24
JetBlue Logo
8:26 am - 4:34 amSFO-SDQ
16h 08m1 stop
JetBlue Logo
3:28 pm - 9:59 amSDQ-SFO
22h 31m1 stop
$477JetBlue
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Wed, Feb 11 - Mon, Feb 16
JetBlue Logo
3:05 pm - 2:13 pmSFO-SDQ
19h 08m1 stop
JetBlue Logo
3:25 pm - 11:30 pmSDQ-SFO
12h 05m1 stop
$482JetBlue
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Thu, Jan 22 - Mon, Feb 9
JetBlue Logo
8:26 am - 4:34 amSFO-SDQ
16h 08m1 stop
JetBlue Logo
4:15 am - 2:12 pmSDQ-SFO
13h 57m1 stop
$488JetBlue
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Fri, Feb 6 - Mon, Feb 9
Avianca Logo
2:20 pm - 10:50 amSFO-SDQ
17h 30m2 stops
Avianca Logo
11:45 am - 12:35 pmSDQ-SFO
27h 50m2 stops
$490Avianca
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Mon, Apr 27 - Mon, May 25
Avianca Logo
1:20 pm - 4:50 pmSFO-SDQ
23h 30m2 stops
Avianca Logo
12:20 pm - 12:00 pmSDQ-SFO
27h 40m2 stops
$500Avianca
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Fri, Feb 6 - Tue, Feb 10

Avianca flights from San Francisco to Santo Domingo

Our best Avianca deals on San Francisco to Santo Domingo flight tickets
Avianca
Apr 27
SFO2:20 pmSan Francisco
17h 30m
2 stops
SDQ10:50 amSanto Domingo Las Americas
May 25
SDQ11:45 amSanto Domingo Las Americas
27h 50m
2 stops
SFO12:35 pmSan Francisco
$490
Find similar
Avianca
Feb 6
SFO1:20 pmSan Francisco
23h 30m
2 stops
SDQ4:50 pmSanto Domingo Las Americas
Feb 10
SDQ12:20 pmSanto Domingo Las Americas
27h 40m
2 stops
SFO12:00 pmSan Francisco
$500
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Avianca
Feb 5
SFO1:35 amSan Francisco
29h 50m
2 stops
SDQ11:25 amSanto Domingo Las Americas
Feb 10
SDQ12:20 pmSanto Domingo Las Americas
27h 40m
2 stops
SFO12:00 pmSan Francisco
$507
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American Airlines flights from San Francisco to Santo Domingo

Our best American Airlines deals on San Francisco to Santo Domingo flight tickets
American Airlines
Jan 22
SFO12:17 amSan Francisco
13h 12m
2 stops
SDQ5:29 pmSanto Domingo Las Americas
Feb 10
SDQ6:00 amSanto Domingo Las Americas
14h 01m
2 stops
SFO4:01 pmSan Francisco
$622
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American Airlines
Nov 22
SFO12:59 amSan Francisco
12h 09m
2 stops
SDQ5:08 pmSanto Domingo Las Americas
Dec 14
SDQ1:28 pmSanto Domingo Las Americas
13h 31m
1 stop
SFO10:59 pmSan Francisco
$877
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American Airlines
Nov 19
SFO4:21 pmSan Francisco
15h 58m
2 stops
SDQ12:19 pmSanto Domingo Las Americas
Nov 24
SDQ6:00 amSanto Domingo Las Americas
15h 21m
2 stops
SFO5:21 pmSan Francisco
$1,327
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momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 2/6

12:15 pm-4:34 am

1 stop12h 19m

Santo Domingo Las Americas

Tue 2/10

6:00 am-7:15 pm

1 stop17h 15m

$438

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 4/30

9:30 pm-2:04 pm

1 stop13h 34m

Santo Domingo Las Americas

Sun 5/3

3:07 am-5:35 pm

1 stop17h 28m

$446

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 1/23

8:45 pm-2:13 pm

1 stop13h 28m

Santo Domingo Las Americas

Mon 2/9

6:00 am-7:15 pm

1 stop17h 15m

$454

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 12/7

12:36 am-2:26 am

1 stop21h 50m

Santo Domingo Las Americas

Wed 12/24

12:40 pm-11:17 pm

1 stop14h 37m

$456

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 1/17

11:20 pm-3:07 pm

1 stop11h 47m

Santo Domingo Las Americas

Sat 1/24

4:40 pm-7:48 am

2 stops19h 08m

$473

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/11

8:26 am-4:34 am

1 stop16h 08m

Santo Domingo Las Americas

Mon 2/16

3:28 pm-9:59 am

1 stop22h 31m

$477

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 1/22

3:05 pm-2:13 pm

1 stop19h 08m

Santo Domingo Las Americas

Mon 2/9

3:25 pm-11:30 pm

1 stop12h 05m

$482

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 2/6

8:26 am-4:34 am

1 stop16h 08m

Santo Domingo Las Americas

Mon 2/9

4:15 am-2:12 pm

1 stop13h 57m

$488

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 4/27

2:20 pm-10:50 am

2 stops17h 30m

Santo Domingo Las Americas

Mon 5/25

11:45 am-12:35 pm

2 stops27h 50m

$490

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 2/6

1:20 pm-4:50 pm

2 stops23h 30m

Santo Domingo Las Americas

Tue 2/10

12:20 pm-12:00 pm

2 stops27h 40m

$500

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until September to fly from San Francisco, when ticket prices are also cheap, with an average price of $589.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $621. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $753.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $621. Try not to purchase tickets in the morning because they tend to be around $750. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $659 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $585 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 13% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of November 2025, prices for San Francisco to Santo Domingo flights are approximately 7% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Direct flights

None
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 10h 32m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $378Free CancellationRating
7.4
1,668 reviews
Search Aeromexico flights
JetBluePriceFrom $453Free CancellationRating
7.2
2,907 reviews
Search JetBlue flights
AviancaPriceFrom $487Free CancellationRating
6.6
2,476 reviews
Search Avianca flights
Copa AirlinesPriceFrom $497Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
DeltaPriceFrom $637Free CancellationRating
7.9
8,007 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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