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Cheap flights from San Francisco to Santo Domingo from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
1:20 pm - 11:25 am
SFO
-
SDQ
18h 05m2 stops
Avianca Logo
5:45 pm - 11:20 pm
SDQ
-
SFO
33h 35m2 stops
$420Avianca
Mon, Jan 26 - Mon, Feb 2
JetBlue Logo
12:20 pm - 4:35 am
SFO
-
SDQ
12h 15m1 stop
JetBlue Logo
6:00 am - 7:15 pm
SDQ
-
SFO
17h 15m1 stop
$432JetBlue
Thu, Jan 22 - Mon, Feb 9
JetBlue Logo
10:39 pm - 2:18 pm
SFO
-
SDQ
11h 39m1 stop
JetBlue Logo
3:28 pm - 11:58 pm
SDQ
-
SFO
12h 30m1 stop
$433JetBlue
Thu, Feb 26 - Tue, Mar 3
JetBlue Logo
10:50 am - 1:57 am
SFO
-
SDQ
11h 07m1 stop
JetBlue Logo
3:25 pm - 11:30 pm
SDQ
-
SFO
12h 05m1 stop
$450JetBlue
Fri, Jan 30 - Fri, Feb 6
Avianca Logo
11:10 pm - 4:50 pm
SFO
-
SDQ
13h 40m2 stops
Avianca Logo
5:45 pm - 11:20 pm
SDQ
-
SFO
33h 35m2 stops
$455Avianca
Fri, Jan 30 - Fri, Feb 6
JetBlue Logo
8:00 am - 1:58 am
SFO
-
SDQ
13h 58m1 stop
JetBlue Logo
3:28 pm - 11:58 pm
SDQ
-
SFO
12h 30m1 stop
$462JetBlue
Thu, Feb 26 - Tue, Mar 3
Avianca Logo
2:20 pm - 5:15 pm
SFO
-
SDQ
23h 55m2 stops
Avianca Logo
6:10 pm - 10:45 pm
SDQ
-
SFO
31h 35m2 stops
$465Avianca
Tue, Apr 7 - Sun, Apr 12
JetBlue Logo
10:50 am - 1:57 am
SFO
-
SDQ
11h 07m1 stop
JetBlue Logo
8:45 pm - 9:41 am
SDQ
-
SFO
16h 56m1 stop
$473JetBlue
Fri, Jan 23 - Tue, Feb 10
JetBlue Logo
7:00 am - 12:16 am
SFO
-
SDQ
14h 16m1 stop
JetBlue Logo
9:16 am - 2:50 pm
SDQ
-
SFO
32h 34m2 stops
$474JetBlue
Mon, Mar 16 - Tue, Mar 24
JetBlue Logo
11:30 pm - 8:30 pm
SFO
-
SDQ
17h 00m1 stop
JetBlue Logo
5:19 am - 10:45 am
SDQ
-
SFO
33h 26m1 stop
$488JetBlue
Mon, Feb 23 - Sun, Mar 8

JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Jan 22
SFO12:20 pmSan Francisco
12h 15m
1 stop
SDQ4:35 amSanto Domingo Las Americas
Feb 9
SDQ6:00 amSanto Domingo Las Americas
17h 15m
1 stop
SFO7:15 pmSan Francisco
$432
Find similar
JetBlue
Feb 26
SFO10:39 pmSan Francisco
11h 39m
1 stop
SDQ2:18 pmSanto Domingo Las Americas
Mar 3
SDQ3:28 pmSanto Domingo Las Americas
12h 30m
1 stop
SFO11:58 pmSan Francisco
$433
Find similar
JetBlue
Jan 30
SFO10:50 amSan Francisco
11h 07m
1 stop
SDQ1:57 amSanto Domingo Las Americas
Feb 6
SDQ3:25 pmSanto Domingo Las Americas
12h 05m
1 stop
SFO11:30 pmSan Francisco
$450
Find similar

American Airlines flights from San Francisco to Santo Domingo

Our best American Airlines deals on San Francisco to Santo Domingo flight tickets
American Airlines
Feb 25
SFO12:29 amSan Francisco
13h 14m
2 stops
SDQ5:43 pmSanto Domingo Las Americas
Mar 3
SDQ10:48 amSanto Domingo Las Americas
13h 32m
2 stops
SFO8:20 pmSan Francisco
$622
Find similar
American Airlines
Jan 21
SFO12:17 amSan Francisco
11h 28m
2 stops
SDQ3:45 pmSanto Domingo Las Americas
Feb 9
SDQ6:00 amSanto Domingo Las Americas
17h 12m
2 stops
SFO7:12 pmSan Francisco
$642
Find similar
American Airlines
Feb 23
SFO7:12 pmSan Francisco
10h 36m
2 stops
SDQ9:48 amSanto Domingo Las Americas
Mar 8
SDQ5:52 pmSanto Domingo Las Americas
19h 58m
1 stop
SFO10:50 amSan Francisco
$647
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 1/26

1:20 pm-11:25 am

2 stops18h 05m

Santo Domingo Las Americas

Mon 2/2

5:45 pm-11:20 pm

2 stops33h 35m

$420

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 1/22

12:20 pm-4:35 am

1 stop12h 15m

Santo Domingo Las Americas

Mon 2/9

6:00 am-7:15 pm

1 stop17h 15m

$432

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 2/26

10:39 pm-2:18 pm

1 stop11h 39m

Santo Domingo Las Americas

Tue 3/3

3:28 pm-11:58 pm

1 stop12h 30m

$433

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 1/30

10:50 am-1:57 am

1 stop11h 07m

Santo Domingo Las Americas

Fri 2/6

3:25 pm-11:30 pm

1 stop12h 05m

$450

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 1/30

11:10 pm-4:50 pm

2 stops13h 40m

Santo Domingo Las Americas

Fri 2/6

5:45 pm-11:20 pm

2 stops33h 35m

$455

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 2/26

8:00 am-1:58 am

1 stop13h 58m

Santo Domingo Las Americas

Tue 3/3

3:28 pm-11:58 pm

1 stop12h 30m

$462

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 4/7

2:20 pm-5:15 pm

2 stops23h 55m

Santo Domingo Las Americas

Sun 4/12

6:10 pm-10:45 pm

2 stops31h 35m

$465

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 1/23

10:50 am-1:57 am

1 stop11h 07m

Santo Domingo Las Americas

Tue 2/10

8:45 pm-9:41 am

1 stop16h 56m

$473

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 3/16

7:00 am-12:16 am

1 stop14h 16m

Santo Domingo Las Americas

Tue 3/24

9:16 am-2:50 pm

2 stops32h 34m

$474

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 2/23

11:30 pm-8:30 pm

1 stop17h 00m

Santo Domingo Las Americas

Sun 3/8

5:19 am-10:45 am

1 stop33h 26m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $588.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $621. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $753.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $621. Try not to purchase tickets in the morning because they tend to be around $750. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $649 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $575 on momondo.

How have San Francisco to Santo Domingo flight prices changed over time?

As of December 2025, prices for San Francisco to Santo Domingo flights are approximately 15% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

10h 28m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 10h 28m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 10h 28m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $453Free CancellationRating
7.2
2,896 reviews
Search JetBlue flights
AviancaPriceFrom $487Free CancellationRating
6.6
2,490 reviews
Search Avianca flights
Copa AirlinesPriceFrom $497Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
DeltaPriceFrom $600Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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