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Cheap flights from San Francisco to Santo Domingo from $181

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 3/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
8:44 pm - 5:14 pm
SFO
-
SDQ
16h 30m
1 stop
JetBlue Logo
8:56 pm - 10:45 am
SDQ
-
SFO
16h 49m
1 stop
$429JetBlue
Tue, Mar 3 - Mon, Mar 16
JetBlue Logo
10:39 pm - 2:18 pm
SFO
-
SDQ
11h 39m
1 stop
JetBlue Logo
9:36 pm - 11:28 am
SDQ
-
SFO
16h 52m
1 stop
$430JetBlue
Mon, Feb 23 - Sun, Mar 8
JetBlue Logo
12:10 pm - 3:54 am
SFO
-
SDQ
12h 44m
1 stop
JetBlue Logo
5:50 am - 8:31 pm
SDQ
-
SFO
17h 41m
1 stop
$431JetBlue
Thu, Apr 9 - Tue, Apr 14
JetBlue Logo
8:20 am - 3:18 am
SFO
-
SDQ
14h 58m
1 stop
JetBlue Logo
5:01 am - 7:31 pm
SDQ
-
SFO
17h 30m
1 stop
$432JetBlue
Wed, Mar 4 - Wed, Mar 18
JetBlue Logo
12:20 pm - 3:31 am
SFO
-
SDQ
12h 11m
1 stop
JetBlue Logo
4:30 am - 5:42 pm
SDQ
-
SFO
16h 12m
1 stop
$433JetBlue
Wed, Mar 25 - Wed, Apr 1
JetBlue Logo
10:39 pm - 2:13 pm
SFO
-
SDQ
11h 34m
1 stop
JetBlue Logo
7:30 am - 7:34 pm
SDQ
-
SFO
16h 04m
1 stop
$434JetBlue
Sun, Feb 22 - Wed, Feb 25
JetBlue Logo
10:39 pm - 2:18 pm
SFO
-
SDQ
11h 39m
1 stop
JetBlue Logo
9:36 pm - 12:57 pm
SDQ
-
SFO
18h 21m
1 stop
$435JetBlue
Mon, Feb 23 - Sun, Mar 8
JetBlue Logo
7:00 am - 1:54 am
SFO
-
SDQ
15h 54m
1 stop
JetBlue Logo
3:01 pm - 11:09 am
SDQ
-
SFO
23h 08m
1 stop
$445JetBlue
Wed, Apr 22 - Wed, Apr 29
Frontier Logo
11:09 pm - 11:56 am
SFO
-
SDQ
32h 47m
2 stops
Frontier Logo
11:56 am - 9:38 pm
SDQ
-
SFO
13h 42m
2 stops
$456Frontier
Sun, Mar 1 - Sat, Mar 7
JetBlue Logo
2:07 pm - 9:53 am
SFO
-
SDQ
15h 46m
1 stop
JetBlue Logo
6:50 pm - 9:49 am
SDQ
-
SFO
17h 59m
1 stop
$458JetBlue
Tue, Mar 3 - Mon, Mar 16

JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Mar 3
SFO8:44 pmSan Francisco
16h 30m
1 stop
SDQ5:14 pmSanto Domingo Las Americas
Mar 16
SDQ8:56 pmSanto Domingo Las Americas
16h 49m
1 stop
SFO10:45 amSan Francisco
$429
JetBlue
Feb 23
SFO10:39 pmSan Francisco
11h 39m
1 stop
SDQ2:18 pmSanto Domingo Las Americas
Mar 3
SDQ6:05 amSanto Domingo Las Americas
18h 24m
1 stop
SFO8:29 pmSan Francisco
$430
JetBlue
Apr 9
SFO12:10 pmSan Francisco
12h 44m
1 stop
SDQ3:54 amSanto Domingo Las Americas
Apr 14
SDQ5:50 amSanto Domingo Las Americas
17h 41m
1 stop
SFO8:31 pmSan Francisco
$431

Frontier flights from San Francisco to Santo Domingo

Our best Frontier deals on San Francisco to Santo Domingo flight tickets
Frontier
Mar 1
SFO11:09 pmSan Francisco
32h 47m
2 stops
SDQ11:56 amSanto Domingo Las Americas
Mar 7
SDQ11:56 amSanto Domingo Las Americas
13h 42m
2 stops
SFO9:38 pmSan Francisco
$456
Frontier
Mar 31
SFO8:09 pmSan Francisco
18h 43m
2 stops
SDQ5:52 pmSanto Domingo Las Americas
Apr 10
SDQ4:08 pmSanto Domingo Las Americas
30h 06m
1 stop
SFO7:14 pmSan Francisco
$571

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 3/3

8:44 pm-5:14 pm

1 stop16h 30m

Santo Domingo Las Americas

Mon 3/16

8:56 pm-10:45 am

1 stop16h 49m

$429

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 2/23

10:39 pm-2:18 pm

1 stop11h 39m

Santo Domingo Las Americas

Sun 3/8

9:36 pm-11:28 am

1 stop16h 52m

$430

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 4/9

12:10 pm-3:54 am

1 stop12h 44m

Santo Domingo Las Americas

Tue 4/14

5:50 am-8:31 pm

1 stop17h 41m

$431

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 3/4

8:20 am-3:18 am

1 stop14h 58m

Santo Domingo Las Americas

Wed 3/18

5:01 am-7:31 pm

1 stop17h 30m

$432

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 3/25

12:20 pm-3:31 am

1 stop12h 11m

Santo Domingo Las Americas

Wed 4/1

4:30 am-5:42 pm

1 stop16h 12m

$433

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 2/22

10:39 pm-2:13 pm

1 stop11h 34m

Santo Domingo Las Americas

Wed 2/25

7:30 am-7:34 pm

1 stop16h 04m

$434

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 2/23

10:39 pm-2:18 pm

1 stop11h 39m

Santo Domingo Las Americas

Sun 3/8

9:36 pm-12:57 pm

1 stop18h 21m

$435

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/22

7:00 am-1:54 am

1 stop15h 54m

Santo Domingo Las Americas

Wed 4/29

3:01 pm-11:09 am

1 stop23h 08m

$445

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 3/1

11:09 pm-11:56 am

2 stops32h 47m

Santo Domingo Las Americas

Sat 3/7

11:56 am-9:38 pm

2 stops13h 42m

$456

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 3/3

2:07 pm-9:53 am

1 stop15h 46m

Santo Domingo Las Americas

Mon 3/16

6:50 pm-9:49 am

1 stop17h 59m

$458

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $588.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $641 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $563 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 32% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of February 2026, prices for San Francisco to Santo Domingo flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

9h 25m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 9h 25m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 9h 25m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $313Free CancellationRating
6.5
2,498 reviews
Search Avianca flights
Copa AirlinesPriceFrom $420Free CancellationRating
7.5
1,556 reviews
Search Copa Airlines flights
JetBluePriceFrom $432Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights
DeltaPriceFrom $587Free CancellationRating
7.9
8,163 reviews
Search Delta flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,247 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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