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Cheap flights from San Francisco to Santo Domingo from $312

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
10:50 am - 1:57 amSFO-SDQ
11h 07m1 stop
JetBlue Logo
6:00 am - 7:15 pmSDQ-SFO
17h 15m1 stop
$432JetBlue
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Fri, Jan 23 - Tue, Feb 10
JetBlue Logo
7:00 am - 1:58 amSFO-SDQ
14h 58m1 stop
JetBlue Logo
7:01 am - 7:29 pmSDQ-SFO
15h 28m1 stop
$436JetBlue
Find Deal
Wed, Feb 25 - Wed, Mar 18
JetBlue Logo
2:10 pm - 3:42 amSFO-SDQ
10h 32m1 stop
JetBlue Logo
1:40 am - 10:46 amSDQ-SFO
12h 06m1 stop
$473JetBlue
Find Deal
Wed, May 6 - Sat, May 9
JetBlue Logo
7:00 am - 1:58 amSFO-SDQ
14h 58m1 stop
JetBlue Logo
9:16 am - 2:11 pmSDQ-SFO
31h 55m2 stops
$474JetBlue
Find Deal
Wed, Feb 25 - Wed, Mar 18
JetBlue Logo
12:59 pm - 4:38 amSFO-SDQ
11h 39m1 stop
JetBlue Logo
1:35 am - 2:12 pmSDQ-SFO
15h 37m1 stop
$478JetBlue
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Wed, Feb 25 - Tue, Mar 17
Avianca Logo
1:20 pm - 4:50 pmSFO-SDQ
23h 30m2 stops
Avianca Logo
5:45 pm - 1:00 pmSDQ-SFO
22h 15m2 stops
$490Avianca
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Wed, Feb 25 - Wed, Mar 18
Copa Airlines Logo
1:42 am - 10:55 pmSFO-SDQ
18h 13m1 stop
Copa Airlines Logo
8:50 am - 6:14 pmSDQ-SFO
12h 24m1 stop
$502Copa Airlines
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Tue, May 5 - Sun, May 10
Multiple Airlines Logo
7:00 am - 4:29 pmSFO-SDQ
29h 29m2 stops
Multiple Airlines Logo
5:30 am - 10:01 pmSDQ-SFO
19h 31m1 stop
$505Multiple Airlines
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Tue, Feb 24 - Tue, Mar 10
Copa Airlines Logo
12:42 am - 10:39 pmSFO-SDQ
17h 57m1 stop
Copa Airlines Logo
8:48 am - 11:40 pmSDQ-SFO
17h 52m1 stop
$507Copa Airlines
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Tue, Feb 24 - Wed, Mar 18
JetBlue Logo
7:00 am - 12:16 amSFO-SDQ
14h 16m1 stop
JetBlue Logo
7:50 pm - 10:43 amSDQ-SFO
17h 53m1 stop
$514JetBlue
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Sat, Mar 14 - Sun, Mar 29

Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
May 5
SFO1:42 amSan Francisco
18h 13m
1 stop
SDQ10:55 pmSanto Domingo Las Americas
May 10
SDQ8:50 amSanto Domingo Las Americas
12h 24m
1 stop
SFO6:14 pmSan Francisco
$502
Find similar
Copa Airlines
Feb 24
SFO12:42 amSan Francisco
17h 57m
1 stop
SDQ10:39 pmSanto Domingo Las Americas
Mar 18
SDQ8:48 amSanto Domingo Las Americas
17h 52m
1 stop
SFO11:40 pmSan Francisco
$507
Find similar
Copa Airlines
Jan 21
SFO12:42 amSan Francisco
13h 23m
1 stop
SDQ6:05 pmSanto Domingo Las Americas
Feb 9
SDQ2:11 pmSanto Domingo Las Americas
13h 09m
1 stop
SFO11:20 pmSan Francisco
$522
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JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Jan 23
SFO10:40 pmSan Francisco
16h 45m
1 stop
SDQ7:25 pmSanto Domingo Las Americas
Feb 9
SDQ3:50 pmSanto Domingo Las Americas
12h 34m
1 stop
SFO12:24 amSan Francisco
$432
Find similar
JetBlue
Feb 25
SFO7:00 amSan Francisco
14h 58m
1 stop
SDQ1:58 amSanto Domingo Las Americas
Mar 18
SDQ7:01 amSanto Domingo Las Americas
15h 28m
1 stop
SFO7:29 pmSan Francisco
$436
Find similar
JetBlue
May 6
SFO2:10 pmSan Francisco
10h 32m
1 stop
SDQ3:42 amSanto Domingo Las Americas
May 9
SDQ1:40 amSanto Domingo Las Americas
12h 06m
1 stop
SFO10:46 amSan Francisco
$473
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 1/23

10:50 am-1:57 am

1 stop11h 07m

Santo Domingo Las Americas

Tue 2/10

6:00 am-7:15 pm

1 stop17h 15m

$432

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/25

7:00 am-1:58 am

1 stop14h 58m

Santo Domingo Las Americas

Wed 3/18

7:01 am-7:29 pm

1 stop15h 28m

$436

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 5/6

2:10 pm-3:42 am

1 stop10h 32m

Santo Domingo Las Americas

Sat 5/9

1:40 am-10:46 am

1 stop12h 06m

$473

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/25

7:00 am-1:58 am

1 stop14h 58m

Santo Domingo Las Americas

Wed 3/18

9:16 am-2:11 pm

2 stops31h 55m

$474

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/25

12:59 pm-4:38 am

1 stop11h 39m

Santo Domingo Las Americas

Tue 3/17

1:35 am-2:12 pm

1 stop15h 37m

$478

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/25

1:20 pm-4:50 pm

2 stops23h 30m

Santo Domingo Las Americas

Wed 3/18

5:45 pm-1:00 pm

2 stops22h 15m

$490

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 5/5

1:42 am-10:55 pm

1 stop18h 13m

Santo Domingo Las Americas

Sun 5/10

8:50 am-6:14 pm

1 stop12h 24m

$502

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 2/24

7:00 am-4:29 pm

2 stops29h 29m

Santo Domingo Las Americas

Tue 3/10

5:30 am-10:01 pm

1 stop19h 31m

$505

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 2/24

12:42 am-10:39 pm

1 stop17h 57m

Santo Domingo Las Americas

Wed 3/18

8:48 am-11:40 pm

1 stop17h 52m

$507

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 3/14

7:00 am-12:16 am

1 stop14h 16m

Santo Domingo Las Americas

Sun 3/29

7:50 pm-10:43 am

1 stop17h 53m

$514

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until September to fly from San Francisco, when ticket prices are also cheap, with an average price of $589.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $621. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $753.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $621. Try not to purchase tickets in the morning because they tend to be around $750. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $660 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $585 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 13% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of November 2025, prices for San Francisco to Santo Domingo flights are approximately 10% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Direct flights

None
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 10h 32m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $378Free CancellationRating
7.4
1,659 reviews
Search Aeromexico flights
JetBluePriceFrom $453Free CancellationRating
7.2
2,903 reviews
Search JetBlue flights
AviancaPriceFrom $487Free CancellationRating
6.6
2,480 reviews
Search Avianca flights
Copa AirlinesPriceFrom $497Free CancellationRating
7.6
1,567 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $637Free CancellationRating
7.9
7,996 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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