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Cheap flights from San Francisco to Santo Domingo from $210

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

JetBlue Logo
10:15 pm - 1:24 pmSFO-SDQ
12h 09m1 stop
JetBlue Logo
2:34 pm - 11:12 pmSDQ-SFO
11h 38m1 stop
$448JetBlue
Find Deal
Wed, Oct 8 - Tue, Oct 21
JetBlue Logo
10:35 am - 1:25 pmSFO-SDQ
23h 50m1 stop
JetBlue Logo
2:34 pm - 11:10 pmSDQ-SFO
11h 36m1 stop
$450JetBlue
Find Deal
Wed, Sep 17 - Wed, Sep 24
JetBlue Logo
11:20 pm - 1:24 pmSFO-SDQ
11h 04m1 stop
JetBlue Logo
2:34 pm - 11:10 pmSDQ-SFO
11h 36m1 stop
$457JetBlue
Find Deal
Mon, Sep 15 - Tue, Sep 30
JetBlue Logo
11:20 pm - 1:24 pmSFO-SDQ
11h 04m1 stop
JetBlue Logo
2:34 pm - 11:10 pmSDQ-SFO
11h 36m1 stop
$459JetBlue
Find Deal
Tue, Sep 23 - Sat, Oct 4
Logo
7:00 am - 12:15 pmSFO-SDQ
26h 15m1 stop
Logo
3:35 pm - 1:17 pmSDQ-SFO
24h 42m2 stops
$478
Find Deal
Mon, Sep 15 - Sun, Sep 21
Logo
10:37 pm - 1:07 pmSFO-SDQ
35h 30m2 stops
Logo
1:20 pm - 11:09 pmSDQ-SFO
12h 49m1 stop
$482
Find Deal
Thu, Sep 11 - Tue, Sep 23
Copa Airlines Logo
1:30 am - 4:17 pmSFO-SDQ
11h 47m1 stop
Copa Airlines Logo
2:09 pm - 11:25 pmSDQ-SFO
12h 16m1 stop
$487Copa Airlines
Find Deal
Mon, Sep 15 - Tue, Sep 23
Copa Airlines Logo
1:30 am - 4:17 pmSFO-SDQ
11h 47m1 stop
Copa Airlines Logo
8:59 am - 11:25 pmSDQ-SFO
17h 26m1 stop
$498Copa Airlines
Find Deal
Sun, Sep 14 - Tue, Sep 30
Avianca Logo
2:20 pm - 10:50 amSFO-SDQ
17h 30m2 stops
Avianca Logo
11:45 am - 12:35 pmSDQ-SFO
27h 50m2 stops
$505Avianca
Find Deal
Sun, Sep 14 - Sat, Sep 20
Avianca Logo
2:20 pm - 10:50 amSFO-SDQ
17h 30m2 stops
Avianca Logo
11:45 am - 10:45 pmSDQ-SFO
14h 00m2 stops
$512Avianca
Find Deal
Sun, Oct 5 - Sat, Oct 25

JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Oct 8
SFO10:15 pmSan Francisco
12h 09m
1 stop
SDQ1:24 pmSanto Domingo Las Americas
Oct 21
SDQ2:34 pmSanto Domingo Las Americas
11h 38m
1 stop
SFO11:12 pmSan Francisco
$448
Find similar
JetBlue
Sep 17
SFO10:35 amSan Francisco
23h 50m
1 stop
SDQ1:25 pmSanto Domingo Las Americas
Sep 24
SDQ2:34 pmSanto Domingo Las Americas
11h 36m
1 stop
SFO11:10 pmSan Francisco
$450
Find similar
JetBlue
Sep 15
SFO11:20 pmSan Francisco
11h 04m
1 stop
SDQ1:24 pmSanto Domingo Las Americas
Sep 30
SDQ2:34 pmSanto Domingo Las Americas
11h 36m
1 stop
SFO11:10 pmSan Francisco
$457
Find similar

Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
Sep 15
SFO1:30 amSan Francisco
11h 47m
1 stop
SDQ4:17 pmSanto Domingo Las Americas
Sep 23
SDQ2:09 pmSanto Domingo Las Americas
12h 16m
1 stop
SFO11:25 pmSan Francisco
$487
Find similar
Copa Airlines
Sep 14
SFO1:30 amSan Francisco
11h 47m
1 stop
SDQ4:17 pmSanto Domingo Las Americas
Sep 30
SDQ8:59 amSanto Domingo Las Americas
17h 26m
1 stop
SFO11:25 pmSan Francisco
$498
Find similar
Copa Airlines
Sep 10
SFO1:30 amSan Francisco
11h 47m
1 stop
SDQ4:17 pmSanto Domingo Las Americas
Sep 23
SDQ2:09 pmSanto Domingo Las Americas
12h 16m
1 stop
SFO11:25 pmSan Francisco
$507
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 19, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 10/8

10:15 pm-1:24 pm

1 stop12h 09m

Santo Domingo Las Americas

Tue 10/21

2:34 pm-11:12 pm

1 stop11h 38m

$448

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 9/17

10:35 am-1:25 pm

1 stop23h 50m

Santo Domingo Las Americas

Wed 9/24

2:34 pm-11:10 pm

1 stop11h 36m

$450

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 9/15

11:20 pm-1:24 pm

1 stop11h 04m

Santo Domingo Las Americas

Tue 9/30

2:34 pm-11:10 pm

1 stop11h 36m

$457

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 9/23

11:20 pm-1:24 pm

1 stop11h 04m

Santo Domingo Las Americas

Sat 10/4

2:34 pm-11:10 pm

1 stop11h 36m

$459

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 9/15

7:00 am-12:15 pm

1 stop26h 15m

Santo Domingo Las Americas

Sun 9/21

3:35 pm-1:17 pm

2 stops24h 42m

$478

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 9/11

10:37 pm-1:07 pm

2 stops35h 30m

Santo Domingo Las Americas

Tue 9/23

1:20 pm-11:09 pm

1 stop12h 49m

$482

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 9/15

1:30 am-4:17 pm

1 stop11h 47m

Santo Domingo Las Americas

Tue 9/23

2:09 pm-11:25 pm

1 stop12h 16m

$487

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 9/14

1:30 am-4:17 pm

1 stop11h 47m

Santo Domingo Las Americas

Tue 9/30

8:59 am-11:25 pm

1 stop17h 26m

$498

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 9/14

2:20 pm-10:50 am

2 stops17h 30m

Santo Domingo Las Americas

Sat 9/20

11:45 am-12:35 pm

2 stops27h 50m

$505

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 10/5

2:20 pm-10:50 am

2 stops17h 30m

Santo Domingo Las Americas

Sat 10/25

11:45 am-10:45 pm

2 stops14h 00m

$512

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $591.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $621. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $753.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $621. Try not to purchase tickets in the morning because they tend to be around $750. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $685 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $561 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 3% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of August 2025, prices for San Francisco to Santo Domingo flights are approximately 12% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Best Price Found

$210

Fastest flight time

11h 04m

Direct flights

None

Airports in Santo Domingo

1 airport
The best one-way flight to Santo Domingo from San Francisco in the past 72 hours is $210. The best round-trip flight deal from San Francisco to Santo Domingo found on momondo in the last 72 hours is $448.
The fastest flight from San Francisco to Santo Domingo takes 11h 04m
There are no direct flights from San Francisco to Santo Domingo. Popular non-direct route for this connection is San Francisco Airport - Santo Domingo Las Americas Airport.
There is 1 airport near Santo Domingo: Santo Domingo Las Americas (SDQ)
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  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 11h 04m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $378Free CancellationRating
7.5
1,718 reviews
Search Aeromexico flights
JetBluePriceFrom $447Free CancellationRating
7.2
2,915 reviews
Search JetBlue flights
AviancaPriceFrom $487Free CancellationRating
6.7
2,409 reviews
Search Avianca flights
Copa AirlinesPriceFrom $496Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights
DeltaPriceFrom $497Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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