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Cheap flights from San Francisco to Santo Domingo from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 12/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
12:15 pm - 4:34 amSFO-SDQ
12h 19m1 stop
JetBlue Logo
3:25 pm - 11:30 pmSDQ-SFO
12h 05m1 stop
$448JetBlue
Find Deal
Thu, Jan 22 - Mon, Feb 9
JetBlue Logo
11:15 am - 4:31 amSFO-SDQ
13h 16m1 stop
JetBlue Logo
6:20 am - 8:19 pmSDQ-SFO
17h 59m1 stop
$454JetBlue
Find Deal
Tue, Mar 3 - Thu, Mar 5
Avianca Logo
1:20 pm - 11:25 amSFO-SDQ
18h 05m2 stops
Avianca Logo
5:45 pm - 11:20 pmSDQ-SFO
33h 35m2 stops
$490Avianca
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Wed, Feb 25 - Fri, Feb 27
Copa Airlines Logo
12:36 am - 4:15 pmSFO-SDQ
11h 39m1 stop
Copa Airlines Logo
6:39 pm - 11:17 pmSDQ-SFO
32h 38m1 stop
$496Copa Airlines
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Sun, Nov 16 - Wed, Dec 3
Copa Airlines Logo
12:42 am - 6:05 pmSFO-SDQ
13h 23m1 stop
Copa Airlines Logo
6:00 am - 11:20 pmSDQ-SFO
21h 20m1 stop
$498Copa Airlines
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Thu, Jan 22 - Tue, Feb 10
JetBlue Logo
7:00 am - 1:59 amSFO-SDQ
14h 59m1 stop
JetBlue Logo
4:09 am - 11:23 pmSDQ-SFO
23h 14m1 stop
$500JetBlue
Find Deal
Mon, Nov 17 - Fri, Nov 21
Avianca Logo
1:35 am - 11:25 amSFO-SDQ
29h 50m2 stops
Avianca Logo
5:45 pm - 11:20 pmSDQ-SFO
33h 35m2 stops
$507Avianca
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Tue, Feb 24 - Fri, Feb 27
American Airlines Logo
11:59 pm - 3:45 pmSFO-SDQ
11h 46m2 stops
American Airlines Logo
6:00 am - 5:20 pmSDQ-SFO
15h 20m2 stops
$599American Airlines
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Mon, Nov 17 - Wed, Dec 3
Aeromexico Logo
11:27 am - 7:18 amSFO-SDQ
39h 51m2 stops
Aeromexico Logo
11:01 am - 11:51 amSDQ-SFO
28h 50m1 stop
$602Aeromexico
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Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
11:59 pm - 3:58 pmSFO-SDQ
11h 59m1 stop
American Airlines Logo
11:07 am - 9:39 pmSDQ-SFO
14h 32m1 stop
$608American Airlines
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Mon, Dec 8 - Fri, Dec 19

JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Jan 22
SFO12:15 pmSan Francisco
12h 19m
1 stop
SDQ4:34 amSanto Domingo Las Americas
Feb 9
SDQ3:25 pmSanto Domingo Las Americas
12h 05m
1 stop
SFO11:30 pmSan Francisco
$448
Find similar
JetBlue
Mar 3
SFO11:15 amSan Francisco
13h 16m
1 stop
SDQ4:31 amSanto Domingo Las Americas
Mar 5
SDQ6:20 amSanto Domingo Las Americas
17h 59m
1 stop
SFO8:19 pmSan Francisco
$454
Find similar
JetBlue
Nov 17
SFO7:00 amSan Francisco
14h 59m
1 stop
SDQ1:59 amSanto Domingo Las Americas
Nov 21
SDQ4:09 amSanto Domingo Las Americas
23h 14m
1 stop
SFO11:23 pmSan Francisco
$500
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Avianca flights from San Francisco to Santo Domingo

Our best Avianca deals on San Francisco to Santo Domingo flight tickets
Avianca
Feb 25
SFO1:20 pmSan Francisco
18h 05m
2 stops
SDQ11:25 amSanto Domingo Las Americas
Feb 27
SDQ5:45 pmSanto Domingo Las Americas
33h 35m
2 stops
SFO11:20 pmSan Francisco
$490
Find similar
Avianca
Feb 24
SFO1:35 amSan Francisco
29h 50m
2 stops
SDQ11:25 amSanto Domingo Las Americas
Feb 27
SDQ5:45 pmSanto Domingo Las Americas
33h 35m
2 stops
SFO11:20 pmSan Francisco
$507
Find similar
Avianca
Feb 24
SFO1:35 amSan Francisco
35h 15m
2 stops
SDQ4:50 pmSanto Domingo Las Americas
Mar 9
SDQ5:45 pmSanto Domingo Las Americas
32h 55m
2 stops
SFO11:40 pmSan Francisco
$517
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momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 1/22

12:15 pm-4:34 am

1 stop12h 19m

Santo Domingo Las Americas

Mon 2/9

3:25 pm-11:30 pm

1 stop12h 05m

$448

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 3/3

11:15 am-4:31 am

1 stop13h 16m

Santo Domingo Las Americas

Thu 3/5

6:20 am-8:19 pm

1 stop17h 59m

$454

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 2/25

1:20 pm-11:25 am

2 stops18h 05m

Santo Domingo Las Americas

Fri 2/27

5:45 pm-11:20 pm

2 stops33h 35m

$490

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 11/16

12:36 am-4:15 pm

1 stop11h 39m

Santo Domingo Las Americas

Wed 12/3

6:39 pm-11:17 pm

1 stop32h 38m

$496

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 1/22

12:42 am-6:05 pm

1 stop13h 23m

Santo Domingo Las Americas

Tue 2/10

6:00 am-11:20 pm

1 stop21h 20m

$498

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 11/17

7:00 am-1:59 am

1 stop14h 59m

Santo Domingo Las Americas

Fri 11/21

4:09 am-11:23 pm

1 stop23h 14m

$500

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 2/24

1:35 am-11:25 am

2 stops29h 50m

Santo Domingo Las Americas

Fri 2/27

5:45 pm-11:20 pm

2 stops33h 35m

$507

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 11/17

11:59 pm-3:45 pm

2 stops11h 46m

Santo Domingo Las Americas

Wed 12/3

6:00 am-5:20 pm

2 stops15h 20m

$599

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 2/12

11:27 am-7:18 am

2 stops39h 51m

Santo Domingo Las Americas

Mon 2/16

11:01 am-11:51 am

1 stop28h 50m

$602

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 12/8

11:59 pm-3:58 pm

1 stop11h 59m

Santo Domingo Las Americas

Fri 12/19

11:07 am-9:39 pm

1 stop14h 32m

$608

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $598.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $621. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $753.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $621. Try not to purchase tickets in the morning because they tend to be around $750. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $676 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $580 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 13% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of October 2025, prices for San Francisco to Santo Domingo flights are approximately 12% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Direct flights

None
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 10h 24m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $378Free CancellationRating
7.4
1,681 reviews
Search Aeromexico flights
JetBluePriceFrom $453Free CancellationRating
7.2
2,909 reviews
Search JetBlue flights
AviancaPriceFrom $487Free CancellationRating
6.6
2,456 reviews
Search Avianca flights
Copa AirlinesPriceFrom $497Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,028 reviews
Search American Airlines flights
DeltaPriceFrom $637Free CancellationRating
7.9
7,979 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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