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Cheap flights from San Francisco to Santo Domingo from $221

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
7:36 pm - 10:54 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
23h 18m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:06 pm - 11:15 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
15h 09m1 stop Panama City Tocumen Intl
$554Copa Airlines
Mon, Jan 25 - Thu, Jan 28
Copa Airlines Logo
7:55 pm - 11:36 amSFO  San Francisco-SDQ Santo Domingo Las Americas
12h 41m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:13 pm - 6:28 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
27h 15m1 stop Panama City Tocumen Intl
$581Copa Airlines
Wed, Mar 31 - Sun, Apr 4
Multiple Airlines Logo
6:30 pm - 9:45 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
23h 15m2 stops Las Vegas Harry Reid Intl Miami
Multiple Airlines Logo
1:27 pm - 1:27 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
28h 00m3 stops Philadelphia Chicago O'Hare Intl Las Vegas Harry Reid Intl
$621Multiple Airlines
Mon, Nov 23 - Sun, Dec 6
Multiple Airlines Logo
8:50 am - 5:25 amSFO  San Francisco-SDQ Santo Domingo Las Americas
16h 35m1 stop New York John F Kennedy Intl
Multiple Airlines Logo
10:19 am - 10:34 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
40h 15m2 stops Miami Dallas/Fort Worth
$637Multiple Airlines
Sat, Feb 6 - Wed, Feb 24
American Airlines Logo
9:38 pm - 3:51 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 13m1 stop Miami
American Airlines Logo
7:00 am - 10:54 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
19h 54m1 stop Miami
$675American Airlines
Wed, Nov 25 - Wed, Dec 2
American Airlines Logo
9:38 pm - 3:51 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
14h 13m1 stop Miami
American Airlines Logo
7:00 am - 6:32 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
15h 32m2 stops Miami Dallas/Fort Worth
$680American Airlines
Wed, Nov 25 - Wed, Dec 2
JetBlue Logo
11:25 pm - 1:22 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
9h 57m1 stop Fort Lauderdale
JetBlue Logo
3:04 pm - 11:48 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
12h 44m1 stop Fort Lauderdale
$718JetBlue
Fri, Nov 13 - Sat, Nov 21
JetBlue Logo
9:00 pm - 4:19 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
15h 19m1 stop Fort Lauderdale
JetBlue Logo
2:44 pm - 11:57 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
13h 13m1 stop Fort Lauderdale
$718JetBlue
Fri, Jan 15 - Tue, Jan 19
Avianca Logo
1:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$721Avianca
Mon, Feb 22 - Wed, Mar 3
Avianca Logo
1:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
6:45 pm - 11:55 amSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$721Avianca
Wed, Feb 17 - Mon, Feb 22

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Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
Jan 25
SFO7:36 pmSan Francisco
23h 18m
1 stop
SDQ10:54 pmSanto Domingo Las Americas
Jan 28
SDQ12:06 pmSanto Domingo Las Americas
15h 09m
1 stop
SFO11:15 pmSan Francisco
$554
Copa Airlines
Mar 31
SFO7:55 pmSan Francisco
12h 41m
1 stop
SDQ11:36 amSanto Domingo Las Americas
Apr 4
SDQ6:13 pmSanto Domingo Las Americas
27h 15m
1 stop
SFO6:28 pmSan Francisco
$581
Copa Airlines
Feb 19
SFO7:36 pmSan Francisco
26h 28m
1 stop
SDQ2:04 amSanto Domingo Las Americas
Feb 26
SDQ8:54 amSanto Domingo Las Americas
12h 31m
1 stop
SFO5:25 pmSan Francisco
$608

American Airlines flights from San Francisco to Santo Domingo

Our best American Airlines deals on San Francisco to Santo Domingo flight tickets
American Airlines
Nov 25
SFO9:38 pmSan Francisco
14h 13m
1 stop
SDQ3:51 pmSanto Domingo Las Americas
Dec 2
SDQ7:00 amSanto Domingo Las Americas
15h 32m
2 stops
SFO6:32 pmSan Francisco
$680
American Airlines
Dec 3
SFO7:03 amSan Francisco
10h 39m
2 stops
SDQ9:42 pmSanto Domingo Las Americas
Dec 18
SDQ6:00 amSanto Domingo Las Americas
13h 53m
2 stops
SFO3:53 pmSan Francisco
$732
American Airlines
Dec 1
SFO9:38 pmSan Francisco
10h 17m
1 stop
SDQ11:55 amSanto Domingo Las Americas
Dec 8
SDQ7:00 amSanto Domingo Las Americas
19h 54m
1 stop
SFO10:54 pmSan Francisco
$742

momondo Fare Finder

 
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Mon 1/25

7:36 pm-10:54 pm

1 stop23h 18m

Santo Domingo Las Americas

Thu 1/28

12:06 pm-11:15 pm

1 stop15h 09m

$554

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 3/31

7:55 pm-11:36 am

1 stop12h 41m

Santo Domingo Las Americas

Sun 4/4

6:13 pm-6:28 pm

1 stop27h 15m

$581

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Mon 11/23

6:30 pm-9:45 pm

2 stops23h 15m

Santo Domingo Las Americas

Sun 12/6

1:27 pm-1:27 pm

3 stops28h 00m

$621

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Sat 2/6

8:50 am-5:25 am

1 stop16h 35m

Santo Domingo Las Americas

Wed 2/24

10:19 am-10:34 pm

2 stops40h 15m

$637

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 11/25

9:38 pm-3:51 pm

1 stop14h 13m

Santo Domingo Las Americas

Wed 12/2

7:00 am-10:54 pm

1 stop19h 54m

$675

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 11/25

9:38 pm-3:51 pm

1 stop14h 13m

Santo Domingo Las Americas

Wed 12/2

7:00 am-6:32 pm

2 stops15h 32m

$680
Quickest round-trip

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Fri 11/13

11:25 pm-1:22 pm

1 stop9h 57m

Santo Domingo Las Americas

Sat 11/21

3:04 pm-11:48 pm

1 stop12h 44m

$718

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Fri 1/15

9:00 pm-4:19 pm

1 stop15h 19m

Santo Domingo Las Americas

Tue 1/19

2:44 pm-11:57 pm

1 stop13h 13m

$718

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Mon 2/22

1:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Wed 3/3

6:45 pm-11:55 am

2 stops21h 10m

$721

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 2/17

1:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Mon 2/22

6:45 pm-11:55 am

2 stops21h 10m

$721

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Santo Domingo?

Prices are currently typical for flights on this route.

Typical prices usually range from $548 to $867.
The lowest price recently found on this route was $554.

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in January, then you should wait until May to fly from San Francisco, when ticket prices are also cheap, with an average price of $553.

How far in advance should I book a flight from San Francisco to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $732 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $532 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 2% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of October 2026, prices for San Francisco to Santo Domingo flights are approximately 37% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Best Price Found

$221

Fastest flight time

10h 09m

Direct flights

None
The best one-way flight to Santo Domingo from San Francisco in the past 72 hours is $221. The best round-trip flight deal from San Francisco to Santo Domingo found on momondo in the last 72 hours is $554.
The fastest flight from San Francisco to Santo Domingo takes 10h 09m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

Frequently asked questions about flying from San Francisco to Santo Domingo

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3410.4 mi away from San Francisco. A reasonable flight in good conditions will take 10h 09m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $420Free CancellationRating
7.6
1,554 reviews
Search Copa Airlines flights
JetBluePriceFrom $453Free CancellationRating
7.1
3,076 reviews
Search JetBlue flights
AviancaPriceFrom $542Free CancellationRating
6.5
2,549 reviews
Search Avianca flights
DeltaPriceFrom $587Free CancellationRating
7.8
8,687 reviews
Search Delta flights
American AirlinesPriceFrom $710Free CancellationRating
7.0
12,204 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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