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Cheap flights from San Francisco to Santo Domingo from $255

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
11:00 am - 11:59 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
9h 59m1 stop Fort Lauderdale
JetBlue Logo
2:28 pm - 11:35 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
13h 07m1 stop Fort Lauderdale
$543JetBlue
Thu, Oct 29 - Tue, Nov 3
JetBlue Logo
11:10 pm - 3:16 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 06m1 stop Fort Lauderdale
JetBlue Logo
4:36 pm - 12:07 amSDQ  Santo Domingo Las Americas-SFO San Francisco
10h 31m1 stop Fort Lauderdale
$543JetBlue
Mon, Oct 19 - Thu, Oct 22
American Airlines Logo
9:35 pm - 6:19 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
16h 44m1 stop Miami
American Airlines Logo
7:00 am - 10:44 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
19h 44m1 stop Miami
$548American Airlines
Fri, Nov 6 - Wed, Nov 11
American Airlines Logo
10:58 pm - 1:54 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 56m1 stop Philadelphia
American Airlines Logo
11:09 am - 12:12 amSDQ  Santo Domingo Las Americas-SFO San Francisco
17h 03m1 stop Miami
$548American Airlines
Fri, Nov 13 - Mon, Nov 16
Copa Airlines Logo
7:36 pm - 10:58 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
23h 22m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:10 pm - 11:12 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
15h 02m1 stop Panama City Tocumen Intl
$549Copa Airlines
Wed, Nov 4 - Tue, Nov 10
Copa Airlines Logo
7:36 pm - 4:12 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
16h 36m1 stop Panama City Tocumen Intl
Copa Airlines Logo
8:55 am - 5:25 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
12h 30m1 stop Panama City Tocumen Intl
$551Copa Airlines
Wed, Nov 11 - Sun, Nov 15
Avianca Logo
2:15 pm - 11:50 amSFO  San Francisco-SDQ Santo Domingo Las Americas
18h 35m2 stops San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$552Avianca
Tue, Oct 13 - Tue, Oct 20
Avianca Logo
11:55 pm - 5:55 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
15h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
6:50 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
21h 00m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$552Avianca
Thu, Oct 8 - Wed, Oct 14
Multiple Airlines Logo
11:10 pm - 3:16 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
13h 06m1 stop Fort Lauderdale
Multiple Airlines Logo
6:50 pm - 10:35 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
30h 45m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$621Multiple Airlines
Mon, Oct 19 - Thu, Oct 22
Multiple Airlines Logo
10:59 am - 11:59 pmSFO  San Francisco-SDQ Santo Domingo Las Americas
10h 00m1 stop Fort Lauderdale
Multiple Airlines Logo
12:45 pm - 12:50 pmSDQ  Santo Domingo Las Americas-SFO San Francisco
27h 05m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$621Multiple Airlines
Tue, Sep 1 - Sun, Sep 6

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Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
Nov 11
SFO7:36 pmSan Francisco
16h 36m
1 stop
SDQ4:12 pmSanto Domingo Las Americas
Nov 15
SDQ8:55 amSanto Domingo Las Americas
12h 30m
1 stop
SFO5:25 pmSan Francisco
$551
Copa Airlines
Nov 11
SFO7:36 pmSan Francisco
16h 36m
1 stop
SDQ4:12 pmSanto Domingo Las Americas
Nov 15
SDQ8:55 amSanto Domingo Las Americas
12h 30m
1 stop
SFO5:25 pmSan Francisco
$556
Copa Airlines
Nov 11
SFO7:36 pmSan Francisco
16h 36m
1 stop
SDQ4:12 pmSanto Domingo Las Americas
Nov 15
SDQ8:55 amSanto Domingo Las Americas
12h 30m
1 stop
SFO5:25 pmSan Francisco
$572

American Airlines flights from San Francisco to Santo Domingo

Our best American Airlines deals on San Francisco to Santo Domingo flight tickets
American Airlines
Nov 6
SFO9:35 pmSan Francisco
16h 44m
1 stop
SDQ6:19 pmSanto Domingo Las Americas
Nov 11
SDQ7:00 amSanto Domingo Las Americas
19h 44m
1 stop
SFO10:44 pmSan Francisco
$548
American Airlines
Nov 6
SFO9:35 pmSan Francisco
8h 34m
1 stop
SDQ10:09 amSanto Domingo Las Americas
Nov 11
SDQ7:00 amSanto Domingo Las Americas
18h 00m
2 stops
SFO9:00 pmSan Francisco
$553
American Airlines
Oct 27
SFO7:57 pmSan Francisco
14h 36m
2 stops
SDQ1:33 pmSanto Domingo Las Americas
Nov 1
SDQ4:59 pmSanto Domingo Las Americas
11h 13m
1 stop
SFO12:12 amSan Francisco
$558

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Thu 10/29

11:00 am-11:59 pm

1 stop9h 59m

Santo Domingo Las Americas

Tue 11/3

2:28 pm-11:35 pm

1 stop13h 07m

$543

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Mon 10/19

11:10 pm-3:16 pm

1 stop13h 06m

Santo Domingo Las Americas

Thu 10/22

4:36 pm-12:07 am

1 stop10h 31m

$543

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Fri 11/6

9:35 pm-6:19 pm

1 stop16h 44m

Santo Domingo Las Americas

Wed 11/11

7:00 am-10:44 pm

1 stop19h 44m

$548

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Fri 11/13

10:58 pm-1:54 pm

1 stop10h 56m

Santo Domingo Las Americas

Mon 11/16

11:09 am-12:12 am

1 stop17h 03m

$548

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 11/4

7:36 pm-10:58 pm

1 stop23h 22m

Santo Domingo Las Americas

Tue 11/10

12:10 pm-11:12 pm

1 stop15h 02m

$549

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Wed 11/11

7:36 pm-4:12 pm

1 stop16h 36m

Santo Domingo Las Americas

Sun 11/15

8:55 am-5:25 pm

1 stop12h 30m

$551

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Tue 10/13

2:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Tue 10/20

6:50 pm-12:50 pm

2 stops21h 00m

$552

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Thu 10/8

11:55 pm-5:55 pm

2 stops15h 00m

Santo Domingo Las Americas

Wed 10/14

6:50 pm-12:50 pm

2 stops21h 00m

$552

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Mon 10/19

11:10 pm-3:16 pm

1 stop13h 06m

Santo Domingo Las Americas

Thu 10/22

6:50 pm-10:35 pm

2 stops30h 45m

$621

San FranciscoSanto Domingo

SFO San Francisco - SDQ Santo Domingo Las Americas

SFOSDQ

San Francisco

Tue 9/1

10:59 am-11:59 pm

1 stop10h 00m

Santo Domingo Las Americas

Sun 9/6

12:45 pm-12:50 pm

2 stops27h 05m

$621

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Santo Domingo?

Prices are currently typical for flights on this route.

Typical prices usually range from $535 to $774.
The lowest price recently found on this route was $543.

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $550.

How far in advance should I book a flight from San Francisco to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $681 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $453 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 16% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of August 2026, prices for San Francisco to Santo Domingo flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

9h 29m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 9h 29m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

Frequently asked questions about flying from San Francisco to Santo Domingo

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3410.4 mi away from San Francisco. A reasonable flight in good conditions will take 9h 29m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $313Free CancellationRating
6.5
2,534 reviews
Search Avianca flights
Copa AirlinesPriceFrom $420Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
JetBluePriceFrom $432Free CancellationRating
7.1
3,034 reviews
Search JetBlue flights
DeltaPriceFrom $587Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $679Free CancellationRating
7.1
11,911 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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