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Cheap flights from San Francisco to Santo Domingo from $188

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 4/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
8:16 pm - 10:55 am
SFO
-
SDQ
11h 39m
1 stop
Copa Airlines Logo
2:14 pm - 11:40 pm
SDQ
-
SFO
12h 26m
1 stop
$479Copa Airlines
Wed, May 6 - Wed, May 13
JetBlue Logo
11:10 pm - 12:28 pm
SFO
-
SDQ
10h 18m
1 stop
JetBlue Logo
7:30 pm - 9:23 am
SDQ
-
SFO
16h 53m
1 stop
$490JetBlue
Sat, Apr 18 - Fri, Apr 24
JetBlue Logo
11:05 pm - 12:28 pm
SFO
-
SDQ
10h 23m
1 stop
JetBlue Logo
1:39 pm - 11:56 pm
SDQ
-
SFO
13h 17m
1 stop
$498JetBlue
Tue, Apr 21 - Tue, Apr 28
Copa Airlines Logo
1:12 am - 4:15 pm
SFO
-
SDQ
12h 03m
1 stop
Copa Airlines Logo
12:43 pm - 11:40 pm
SDQ
-
SFO
13h 57m
1 stop
$499Copa Airlines
Tue, Aug 11 - Wed, Aug 19
JetBlue Logo
8:45 pm - 2:50 pm
SFO
-
SDQ
15h 05m
1 stop
JetBlue Logo
8:32 pm - 9:25 am
SDQ
-
SFO
15h 53m
1 stop
$503JetBlue
Mon, May 4 - Fri, May 8
JetBlue Logo
11:10 pm - 12:28 pm
SFO
-
SDQ
10h 18m
1 stop
JetBlue Logo
1:39 pm - 11:56 pm
SDQ
-
SFO
13h 17m
1 stop
$531JetBlue
Sat, Apr 18 - Sat, Apr 25
Copa Airlines Logo
8:21 pm - 11:42 am
SFO
-
SDQ
12h 21m
1 stop
Copa Airlines Logo
8:48 am - 5:59 pm
SDQ
-
SFO
12h 11m
1 stop
$536Copa Airlines
Wed, Aug 12 - Tue, Aug 18
JetBlue Logo
11:05 pm - 12:28 pm
SFO
-
SDQ
10h 23m
1 stop
JetBlue Logo
1:39 pm - 11:56 pm
SDQ
-
SFO
13h 17m
1 stop
$539JetBlue
Sun, Apr 19 - Sat, Apr 25
Avianca Logo
11:55 pm - 5:55 pm
SFO
-
SDQ
15h 00m
2 stops
Avianca Logo
6:50 pm - 12:50 pm
SDQ
-
SFO
21h 00m
2 stops
$541Avianca
Wed, Apr 15 - Tue, Apr 21
JetBlue Logo
11:05 pm - 12:28 pm
SFO
-
SDQ
10h 23m
1 stop
JetBlue Logo
2:42 am - 2:21 pm
SDQ
-
SFO
14h 39m
1 stop
$544JetBlue
Mon, Apr 20 - Fri, Apr 24

Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
May 6
SFO8:16 pmSan Francisco
11h 39m
1 stop
SDQ10:55 amSanto Domingo Las Americas
May 13
SDQ2:14 pmSanto Domingo Las Americas
12h 26m
1 stop
SFO11:40 pmSan Francisco
$479
Copa Airlines
Aug 11
SFO1:12 amSan Francisco
12h 03m
1 stop
SDQ4:15 pmSanto Domingo Las Americas
Aug 19
SDQ12:43 pmSanto Domingo Las Americas
13h 57m
1 stop
SFO11:40 pmSan Francisco
$499
Copa Airlines
Aug 12
SFO8:21 pmSan Francisco
12h 21m
1 stop
SDQ11:42 amSanto Domingo Las Americas
Aug 18
SDQ8:48 amSanto Domingo Las Americas
12h 11m
1 stop
SFO5:59 pmSan Francisco
$536

JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Apr 18
SFO11:10 pmSan Francisco
10h 18m
1 stop
SDQ12:28 pmSanto Domingo Las Americas
Apr 24
SDQ7:30 pmSanto Domingo Las Americas
16h 53m
1 stop
SFO9:23 amSan Francisco
$490
JetBlue
Apr 21
SFO11:05 pmSan Francisco
10h 23m
1 stop
SDQ12:28 pmSanto Domingo Las Americas
Apr 28
SDQ1:39 pmSanto Domingo Las Americas
13h 17m
1 stop
SFO11:56 pmSan Francisco
$498
JetBlue
May 4
SFO8:45 pmSan Francisco
15h 05m
1 stop
SDQ2:50 pmSanto Domingo Las Americas
May 8
SDQ8:32 pmSanto Domingo Las Americas
15h 53m
1 stop
SFO9:25 amSan Francisco
$503

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 5/6

8:16 pm-10:55 am

1 stop11h 39m

Santo Domingo Las Americas

Wed 5/13

2:14 pm-11:40 pm

1 stop12h 26m

$479

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 4/18

11:10 pm-12:28 pm

1 stop10h 18m

Santo Domingo Las Americas

Fri 4/24

7:30 pm-9:23 am

1 stop16h 53m

$490

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 4/21

11:05 pm-12:28 pm

1 stop10h 23m

Santo Domingo Las Americas

Tue 4/28

1:39 pm-11:56 pm

1 stop13h 17m

$498

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 8/11

1:12 am-4:15 pm

1 stop12h 03m

Santo Domingo Las Americas

Wed 8/19

12:43 pm-11:40 pm

1 stop13h 57m

$499

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 5/4

8:45 pm-2:50 pm

1 stop15h 05m

Santo Domingo Las Americas

Fri 5/8

8:32 pm-9:25 am

1 stop15h 53m

$503
Quickest round-trip

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 4/18

11:10 pm-12:28 pm

1 stop10h 18m

Santo Domingo Las Americas

Sat 4/25

1:39 pm-11:56 pm

1 stop13h 17m

$531

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 8/12

8:21 pm-11:42 am

1 stop12h 21m

Santo Domingo Las Americas

Tue 8/18

8:48 am-5:59 pm

1 stop12h 11m

$536

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 4/19

11:05 pm-12:28 pm

1 stop10h 23m

Santo Domingo Las Americas

Sat 4/25

1:39 pm-11:56 pm

1 stop13h 17m

$539

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/15

11:55 pm-5:55 pm

2 stops15h 00m

Santo Domingo Las Americas

Tue 4/21

6:50 pm-12:50 pm

2 stops21h 00m

$541

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 4/20

11:05 pm-12:28 pm

1 stop10h 23m

Santo Domingo Las Americas

Fri 4/24

2:42 am-2:21 pm

1 stop14h 39m

$544

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $550.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $658 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $447 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 14% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of March 2026, prices for San Francisco to Santo Domingo flights are approximately 40% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

10h 23m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 10h 23m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3410.4 mi away from San Francisco. A reasonable flight in good conditions will take 10h 23m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $313Free CancellationRating
6.5
2,505 reviews
Search Avianca flights
Copa AirlinesPriceFrom $420Free CancellationRating
7.5
1,577 reviews
Search Copa Airlines flights
JetBluePriceFrom $433Free CancellationRating
7.2
2,905 reviews
Search JetBlue flights
DeltaPriceFrom $587Free CancellationRating
7.9
8,326 reviews
Search Delta flights
American AirlinesPriceFrom $617Free CancellationRating
7.1
11,494 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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