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Cheap flights from San Francisco to Santo Domingo from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 7/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
2:15 pm - 11:50 am
SFO
-
SDQ
18h 35m
2 stops
Avianca Logo
6:50 pm - 12:50 pm
SDQ
-
SFO
21h 00m
2 stops
$542Avianca
Wed, Jul 8 - Sun, Jul 19
Copa Airlines Logo
7:36 pm - 4:12 pm
SFO
-
SDQ
16h 36m
1 stop
Copa Airlines Logo
8:55 am - 5:25 pm
SDQ
-
SFO
12h 30m
1 stop
$543Copa Airlines
Wed, Nov 11 - Sun, Nov 15
Avianca Logo
7:45 am - 5:55 pm
SFO
-
SDQ
31h 10m
3 stops
Avianca Logo
6:50 pm - 11:55 pm
SDQ
-
SFO
32h 05m
2 stops
$551Avianca
Tue, Aug 4 - Wed, Aug 12
Avianca Logo
2:15 pm - 11:50 am
SFO
-
SDQ
18h 35m
2 stops
Avianca Logo
12:45 pm - 10:35 pm
SDQ
-
SFO
36h 50m
2 stops
$559Avianca
Wed, Jul 8 - Mon, Jul 13
Copa Airlines Logo
7:36 pm - 4:12 pm
SFO
-
SDQ
16h 36m
1 stop
Copa Airlines Logo
12:10 pm - 11:12 pm
SDQ
-
SFO
15h 02m
1 stop
$560Copa Airlines
Thu, Nov 12 - Wed, Nov 25
Avianca Logo
7:45 am - 11:50 am
SFO
-
SDQ
25h 05m
3 stops
Avianca Logo
6:50 pm - 10:35 pm
SDQ
-
SFO
30h 45m
2 stops
$561Avianca
Tue, Aug 4 - Wed, Aug 12
Avianca Logo
2:30 am - 5:55 pm
SFO
-
SDQ
36h 25m
2 stops
Avianca Logo
12:45 pm - 11:55 pm
SDQ
-
SFO
38h 10m
2 stops
$569Avianca
Sat, Jul 11 - Fri, Jul 17
Avianca Logo
2:30 am - 5:55 pm
SFO
-
SDQ
36h 25m
2 stops
Avianca Logo
12:45 pm - 12:50 pm
SDQ
-
SFO
27h 05m
2 stops
$572Avianca
Tue, Jul 28 - Sun, Aug 9
Avianca Logo
11:10 pm - 4:50 pm
SFO
-
SDQ
13h 40m
2 stops
Avianca Logo
5:45 pm - 10:40 pm
SDQ
-
SFO
32h 55m
2 stops
$577Avianca
Tue, Nov 3 - Mon, Nov 9
Copa Airlines Logo
7:36 pm - 10:58 pm
SFO
-
SDQ
23h 22m
1 stop
Copa Airlines Logo
2:24 pm - 11:12 pm
SDQ
-
SFO
12h 48m
1 stop
$580Copa Airlines
Sun, Nov 1 - Sun, Nov 15

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JetBlue flights from San Francisco to Santo Domingo

Our best JetBlue deals on San Francisco to Santo Domingo flight tickets
JetBlue
Aug 30
SFO10:40 pmSan Francisco
13h 41m
1 stop
SDQ3:21 pmSanto Domingo Las Americas
Sep 5
SDQ4:44 pmSanto Domingo Las Americas
20h 03m
1 stop
SFO9:47 amSan Francisco
$607
JetBlue
Aug 25
SFO10:57 amSan Francisco
10h 02m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Sep 14
SDQ2:29 pmSanto Domingo Las Americas
21h 36m
1 stop
SFO9:05 amSan Francisco
$625
JetBlue
Nov 2
SFO10:55 pmSan Francisco
11h 15m
1 stop
SDQ2:10 pmSanto Domingo Las Americas
Nov 11
SDQ2:28 pmSanto Domingo Las Americas
11h 59m
1 stop
SFO10:27 pmSan Francisco
$637

Copa Airlines flights from San Francisco to Santo Domingo

Our best Copa Airlines deals on San Francisco to Santo Domingo flight tickets
Copa Airlines
Nov 11
SFO7:36 pmSan Francisco
16h 36m
1 stop
SDQ4:12 pmSanto Domingo Las Americas
Nov 15
SDQ8:55 amSanto Domingo Las Americas
12h 30m
1 stop
SFO5:25 pmSan Francisco
$543
Copa Airlines
Nov 12
SFO7:36 pmSan Francisco
16h 36m
1 stop
SDQ4:12 pmSanto Domingo Las Americas
Nov 25
SDQ12:10 pmSanto Domingo Las Americas
15h 02m
1 stop
SFO11:12 pmSan Francisco
$560
Copa Airlines
Nov 1
SFO7:36 pmSan Francisco
23h 22m
1 stop
SDQ10:58 pmSanto Domingo Las Americas
Nov 15
SDQ2:24 pmSanto Domingo Las Americas
12h 48m
1 stop
SFO11:12 pmSan Francisco
$580

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 7/8

2:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Sun 7/19

6:50 pm-12:50 pm

2 stops21h 00m

$542
Quickest round-trip

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 11/11

7:36 pm-4:12 pm

1 stop16h 36m

Santo Domingo Las Americas

Sun 11/15

8:55 am-5:25 pm

1 stop12h 30m

$543

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 8/4

7:45 am-5:55 pm

3 stops31h 10m

Santo Domingo Las Americas

Wed 8/12

6:50 pm-11:55 pm

2 stops32h 05m

$551

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 7/8

2:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Mon 7/13

12:45 pm-10:35 pm

2 stops36h 50m

$559

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 11/12

7:36 pm-4:12 pm

1 stop16h 36m

Santo Domingo Las Americas

Wed 11/25

12:10 pm-11:12 pm

1 stop15h 02m

$560

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 8/4

7:45 am-11:50 am

3 stops25h 05m

Santo Domingo Las Americas

Wed 8/12

6:50 pm-10:35 pm

2 stops30h 45m

$561

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 7/11

2:30 am-5:55 pm

2 stops36h 25m

Santo Domingo Las Americas

Fri 7/17

12:45 pm-11:55 pm

2 stops38h 10m

$569

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 7/28

2:30 am-5:55 pm

2 stops36h 25m

Santo Domingo Las Americas

Sun 8/9

12:45 pm-12:50 pm

2 stops27h 05m

$572

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 11/3

11:10 pm-4:50 pm

2 stops13h 40m

Santo Domingo Las Americas

Mon 11/9

5:45 pm-10:40 pm

2 stops32h 55m

$577

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sun 11/1

7:36 pm-10:58 pm

1 stop23h 22m

Santo Domingo Las Americas

Sun 11/15

2:24 pm-11:12 pm

1 stop12h 48m

$580

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $550.

How far in advance should I book a flight from San Francisco to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $657 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $453 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 50% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of June 2026, prices for San Francisco to Santo Domingo flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

11h 21m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 11h 21m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

Frequently asked questions about flying from San Francisco to Santo Domingo

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3410.4 mi away from San Francisco. A reasonable flight in good conditions will take 11h 21m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $420Free CancellationRating
7.5
1,569 reviews
Search Copa Airlines flights
JetBluePriceFrom $432Free CancellationRating
7.1
2,980 reviews
Search JetBlue flights
DeltaPriceFrom $587Free CancellationRating
7.9
8,393 reviews
Search Delta flights
American AirlinesPriceFrom $679Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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