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Cheap flights from San Francisco to Santo Domingo from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santo Domingo departing on 4/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:23 am - 4:14 pm
SFO
-
SDQ
11h 51m
1 stop
Copa Airlines Logo
8:43 am - 11:40 pm
SDQ
-
SFO
17h 57m
1 stop
$421Copa Airlines
Tue, Apr 14 - Wed, Apr 22
Avianca Logo
11:55 pm - 5:55 pm
SFO
-
SDQ
15h 00m
2 stops
Avianca Logo
6:50 pm - 12:50 pm
SDQ
-
SFO
21h 00m
2 stops
$439Avianca
Wed, Apr 15 - Wed, Apr 22
JetBlue Logo
12:10 pm - 3:54 am
SFO
-
SDQ
12h 44m
1 stop
JetBlue Logo
1:40 pm - 11:56 pm
SDQ
-
SFO
13h 16m
1 stop
$446JetBlue
Wed, Apr 8 - Wed, Apr 15
JetBlue Logo
12:10 pm - 3:54 am
SFO
-
SDQ
12h 44m
1 stop
JetBlue Logo
1:40 pm - 11:56 pm
SDQ
-
SFO
13h 16m
1 stop
$450JetBlue
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
10:03 pm - 2:53 pm
SFO
-
SDQ
13h 50m
1 stop
Multiple Airlines Logo
6:55 pm - 10:12 am
SDQ
-
SFO
18h 17m
1 stop
$454Multiple Airlines
Tue, Apr 7 - Thu, Apr 9
Copa Airlines Logo
1:23 am - 10:47 pm
SFO
-
SDQ
18h 24m
1 stop
Copa Airlines Logo
12:38 pm - 11:40 pm
SDQ
-
SFO
14h 02m
1 stop
$455Copa Airlines
Tue, Apr 14 - Sun, Apr 19
Avianca Logo
11:55 pm - 5:55 pm
SFO
-
SDQ
15h 00m
2 stops
Avianca Logo
6:50 pm - 12:50 pm
SDQ
-
SFO
21h 00m
2 stops
$456Avianca
Wed, Apr 8 - Wed, Apr 15
Avianca Logo
2:15 pm - 11:50 am
SFO
-
SDQ
18h 35m
2 stops
Avianca Logo
6:50 pm - 12:50 pm
SDQ
-
SFO
21h 00m
2 stops
$457Avianca
Fri, Apr 10 - Tue, Apr 21
Copa Airlines Logo
8:21 pm - 4:15 pm
SFO
-
SDQ
16h 54m
1 stop
Copa Airlines Logo
6:07 am - 5:59 pm
SDQ
-
SFO
14h 52m
1 stop
$461Copa Airlines
Thu, Aug 20 - Sun, Aug 30
JetBlue Logo
10:50 pm - 6:16 pm
SFO
-
SDQ
16h 26m
1 stop
JetBlue Logo
5:50 am - 7:22 pm
SDQ
-
SFO
16h 32m
1 stop
$463JetBlue
Mon, May 4 - Fri, May 8

Avianca flights from San Francisco to Santo Domingo

Our best Avianca deals on San Francisco to Santo Domingo flight tickets
Avianca
Apr 15
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
Apr 22
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
$439
Avianca
Apr 8
SFO11:55 pmSan Francisco
15h 00m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
Apr 15
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
$456
Avianca
Apr 10
SFO2:15 pmSan Francisco
18h 35m
2 stops
SDQ11:50 amSanto Domingo Las Americas
Apr 21
SDQ6:50 pmSanto Domingo Las Americas
21h 00m
2 stops
SFO12:50 pmSan Francisco
$457

Frontier flights from San Francisco to Santo Domingo

Our best Frontier deals on San Francisco to Santo Domingo flight tickets
Frontier
Apr 7
SFO10:03 pmSan Francisco
13h 50m
1 stop
SDQ2:53 pmSanto Domingo Las Americas
Apr 9
SDQ1:36 pmSanto Domingo Las Americas
32h 43m
2 stops
SFO7:19 pmSan Francisco
$509
Frontier
Apr 7
SFO6:34 pmSan Francisco
17h 19m
2 stops
SDQ2:53 pmSanto Domingo Las Americas
Apr 9
SDQ1:36 pmSanto Domingo Las Americas
32h 43m
2 stops
SFO7:19 pmSan Francisco
$525

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 4/14

1:23 am-4:14 pm

1 stop11h 51m

Santo Domingo Las Americas

Wed 4/22

8:43 am-11:40 pm

1 stop17h 57m

$421

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/15

11:55 pm-5:55 pm

2 stops15h 00m

Santo Domingo Las Americas

Wed 4/22

6:50 pm-12:50 pm

2 stops21h 00m

$439

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/8

12:10 pm-3:54 am

1 stop12h 44m

Santo Domingo Las Americas

Wed 4/15

1:40 pm-11:56 pm

1 stop13h 16m

$446

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/8

12:10 pm-3:54 am

1 stop12h 44m

Santo Domingo Las Americas

Wed 4/15

1:40 pm-11:56 pm

1 stop13h 16m

$450

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 4/7

10:03 pm-2:53 pm

1 stop13h 50m

Santo Domingo Las Americas

Thu 4/9

6:55 pm-10:12 am

1 stop18h 17m

$454

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 4/14

1:23 am-10:47 pm

1 stop18h 24m

Santo Domingo Las Americas

Sun 4/19

12:38 pm-11:40 pm

1 stop14h 02m

$455

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 4/8

11:55 pm-5:55 pm

2 stops15h 00m

Santo Domingo Las Americas

Wed 4/15

6:50 pm-12:50 pm

2 stops21h 00m

$456

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Fri 4/10

2:15 pm-11:50 am

2 stops18h 35m

Santo Domingo Las Americas

Tue 4/21

6:50 pm-12:50 pm

2 stops21h 00m

$457

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Thu 8/20

8:21 pm-4:15 pm

1 stop16h 54m

Santo Domingo Las Americas

Sun 8/30

6:07 am-5:59 pm

1 stop14h 52m

$461

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 5/4

10:50 pm-6:16 pm

1 stop16h 26m

Santo Domingo Las Americas

Fri 5/8

5:50 am-7:22 pm

1 stop16h 32m

$463

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from San Francisco to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in October, then you should wait until January to fly from San Francisco, when ticket prices are also cheap, with an average price of $550.

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $638 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from San Francisco for as low as $453 on momondo.

Can stopping save me money on San Francisco to Santo Domingo flights?

You could potentially save up to 32% on your flight if you consider stops on a San Francisco to Santo Domingo flight.

How have San Francisco to Santo Domingo flight prices changed over time?

As of February 2026, prices for San Francisco to Santo Domingo flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santo Domingo (SFO to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santo Domingo

Fastest flight time

12h 26m

Direct flights

None
The fastest flight from San Francisco to Santo Domingo takes 12h 26m
There are no direct flights from San Francisco to Santo Domingo. There are no popular flight routes from San Francisco to Santo Domingo.
Search flight deals

  • How far is San Francisco to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 3411.1 mi away from San Francisco. A reasonable flight in good conditions will take 12h 26m.

  • When did momondo last update prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

    Prices for flights from San Francisco Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from San Francisco Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santo Domingo?

Best airlines flying from San Francisco to Santo Domingo

Compare and see reviews for airlines that fly from San Francisco to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $313Free CancellationRating
6.6
2,496 reviews
Search Avianca flights
Copa AirlinesPriceFrom $376Free CancellationRating
7.5
1,555 reviews
Search Copa Airlines flights
JetBluePriceFrom $433Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights
DeltaPriceFrom $587Free CancellationRating
7.9
8,241 reviews
Search Delta flights
American AirlinesPriceFrom $619Free CancellationRating
7.2
11,341 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santo Domingo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Santo Domingo for you.

Can I find flights from San Francisco to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santo Domingo?

Once you have performed a search for San Francisco to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from San Francisco are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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