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Cheap flights from San Francisco to Santa Cruz de la Sierra from $320

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santa Cruz de la Sierra departing on 4/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:23 am - 10:42 pm
SFO
-
VVI
18h 19m
1 stop
Copa Airlines Logo
1:15 am - 6:25 pm
VVI
-
SFO
20h 10m
1 stop
$664Copa Airlines
Tue, Apr 7 - Wed, Apr 22
Copa Airlines Logo
7:00 am - 3:40 am
SFO
-
VVI
17h 40m
2 stops
Copa Airlines Logo
11:48 am - 5:13 pm
VVI
-
SFO
32h 25m
2 stops
$672Copa Airlines
Wed, Apr 8 - Thu, Apr 23
United Airlines Logo
5:00 am - 3:40 am
SFO
-
VVI
19h 40m
2 stops
United Airlines Logo
11:48 am - 9:16 am
VVI
-
SFO
24h 28m
2 stops
$679United Airlines
Wed, Apr 8 - Thu, Apr 23
Multiple Airlines Logo
5:00 am - 3:40 am
SFO
-
VVI
19h 40m
2 stops
Multiple Airlines Logo
3:35 am - 6:58 pm
VVI
-
SFO
18h 23m
2 stops
$689Multiple Airlines
Wed, Apr 15 - Tue, Apr 28
United Airlines Logo
6:55 pm - 10:42 pm
SFO
-
VVI
24h 47m
2 stops
United Airlines Logo
11:47 am - 1:35 am
VVI
-
SFO
40h 48m
2 stops
$690United Airlines
Fri, Apr 17 - Sat, May 2
Copa Airlines Logo
1:23 am - 3:40 am
SFO
-
VVI
23h 17m
1 stop
Copa Airlines Logo
1:12 am - 6:14 pm
VVI
-
SFO
20h 02m
1 stop
$712Copa Airlines
Thu, Apr 16 - Fri, May 1
Multiple Airlines Logo
12:43 am - 3:31 am
SFO
-
VVI
22h 48m
2 stops
Multiple Airlines Logo
3:40 am - 5:48 pm
VVI
-
SFO
17h 08m
2 stops
$720Multiple Airlines
Sun, Mar 1 - Tue, Mar 10
United Airlines Logo
1:55 pm - 10:42 pm
SFO
-
VVI
29h 47m
2 stops
United Airlines Logo
11:48 am - 9:16 am
VVI
-
SFO
48h 28m
2 stops
$727United Airlines
Thu, Apr 2 - Sat, Apr 18
Copa Airlines Logo
1:23 am - 10:42 pm
SFO
-
VVI
18h 19m
1 stop
Copa Airlines Logo
1:12 am - 6:14 pm
VVI
-
SFO
20h 02m
1 stop
$739Copa Airlines
Fri, Apr 17 - Sat, May 2
Copa Airlines Logo
12:45 am - 10:42 pm
SFO
-
VVI
18h 57m
2 stops
Copa Airlines Logo
1:12 am - 7:15 am
VVI
-
SFO
33h 03m
2 stops
$745Copa Airlines
Fri, Apr 17 - Sat, May 2

Avianca flights from San Francisco to Santa Cruz de la Sierra

Our best Avianca deals on San Francisco to Santa Cruz de la Sierra flight tickets
Avianca
Mar 2
SFO1:20 pmSan Francisco
33h 15m
2 stops
VVI2:35 amSanta Cruz de la Sierra Viru Viru Intl
Mar 10
VVI3:40 amSanta Cruz de la Sierra Viru Viru Intl
36h 20m
2 stops
SFO1:00 pmSan Francisco
$930
Avianca
Apr 18
SFO11:55 pmSan Francisco
23h 35m
2 stops
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
May 2
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
22h 00m
2 stops
SFO10:35 pmSan Francisco
$941
Avianca
Apr 18
SFO11:55 pmSan Francisco
47h 35m
2 stops
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
May 2
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
36h 15m
2 stops
SFO12:50 pmSan Francisco
$978

Copa Airlines flights from San Francisco to Santa Cruz de la Sierra

Our best Copa Airlines deals on San Francisco to Santa Cruz de la Sierra flight tickets
Copa Airlines
Apr 7
SFO1:23 amSan Francisco
18h 19m
1 stop
VVI10:42 pmSanta Cruz de la Sierra Viru Viru Intl
Apr 22
VVI1:15 amSanta Cruz de la Sierra Viru Viru Intl
20h 10m
1 stop
SFO6:25 pmSan Francisco
$664
Copa Airlines
Apr 8
SFO7:00 amSan Francisco
17h 40m
2 stops
VVI3:40 amSanta Cruz de la Sierra Viru Viru Intl
Apr 23
VVI11:48 amSanta Cruz de la Sierra Viru Viru Intl
32h 25m
2 stops
SFO5:13 pmSan Francisco
$672
Copa Airlines
Apr 16
SFO1:23 amSan Francisco
23h 17m
1 stop
VVI3:40 amSanta Cruz de la Sierra Viru Viru Intl
May 1
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
20h 02m
1 stop
SFO6:14 pmSan Francisco
$712

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Tue 4/7

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

Wed 4/22

1:15 am-6:25 pm

1 stop20h 10m

$664

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 4/8

7:00 am-3:40 am

2 stops17h 40m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/23

11:48 am-5:13 pm

2 stops32h 25m

$672

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 4/8

5:00 am-3:40 am

2 stops19h 40m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/23

11:48 am-9:16 am

2 stops24h 28m

$679

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Wed 4/15

5:00 am-3:40 am

2 stops19h 40m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/28

3:35 am-6:58 pm

2 stops18h 23m

$689

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Fri 4/17

6:55 pm-10:42 pm

2 stops24h 47m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/2

11:47 am-1:35 am

2 stops40h 48m

$690

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Thu 4/16

1:23 am-3:40 am

1 stop23h 17m

Santa Cruz de la Sierra Viru Viru Intl

Fri 5/1

1:12 am-6:14 pm

1 stop20h 02m

$712

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Sun 3/1

12:43 am-3:31 am

2 stops22h 48m

Santa Cruz de la Sierra Viru Viru Intl

Tue 3/10

3:40 am-5:48 pm

2 stops17h 08m

$720

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Thu 4/2

1:55 pm-10:42 pm

2 stops29h 47m

Santa Cruz de la Sierra Viru Viru Intl

Sat 4/18

11:48 am-9:16 am

2 stops48h 28m

$727

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Fri 4/17

1:23 am-10:42 pm

1 stop18h 19m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/2

1:12 am-6:14 pm

1 stop20h 02m

$739

San FranciscoSanta Cruz de la Sierra

SFO - VVI

SFOVVI

San Francisco

Fri 4/17

12:45 am-10:42 pm

2 stops18h 57m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/2

1:12 am-7:15 am

2 stops33h 03m

$745

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Francisco to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Cruz de la Sierra?

The cheapest month to fly to Santa Cruz de la Sierra from San Francisco is in September. Flight prices, which tend to average around $644, are often lower during this time because this is during the off-season. If you don’t want to visit Santa Cruz de la Sierra in September, then you should wait until November to fly from San Francisco, when ticket prices are also cheap, with an average price of $670.

Can stopping save me money on San Francisco to Santa Cruz de la Sierra flights?

You could potentially save up to 29% on your flight if you consider stops on a San Francisco to Santa Cruz de la Sierra flight.

When to book flights from San Francisco to Santa Cruz de la Sierra

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santa Cruz de la Sierra according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santa Cruz de la Sierra (SFO to VVI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santa Cruz de la Sierra

Fastest flight time

18h 31m

Direct flights

None
The fastest flight from San Francisco to Santa Cruz de la Sierra takes 18h 31m
There are no direct flights from San Francisco to Santa Cruz de la Sierra. There are no popular flight routes from San Francisco to Santa Cruz de la Sierra.
Search flight deals

  • How far is San Francisco to Santa Cruz de la Sierra Viru Viru Intl by plane?

    The distance between San Francisco and Santa Cruz de la Sierra Viru Viru Intl is about 5428.9 mi. Flights usually cover this in 18h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from San Francisco Airport to Santa Cruz de la Sierra Viru Viru Intl Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from San Francisco Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Francisco Airport to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The required travel and health documents for your Santa Cruz de la Sierra Viru Viru Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Cruz de la Sierra Viru Viru Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Santa Cruz de la Sierra?

Best airlines flying from San Francisco to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from San Francisco to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $622Free CancellationRating
7.5
1,559 reviews
Search Copa Airlines flights
AviancaPriceFrom $633Free CancellationRating
6.5
2,494 reviews
Search Avianca flights
United AirlinesPriceFrom $644Free CancellationRating
7.4
9,231 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santa Cruz de la Sierra?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from San Francisco to Santa Cruz de la Sierra. momondo saves you time and could save you money on your trip.

Can I find flights from San Francisco to Santa Cruz de la Sierra with flexible booking policies on momondo?

Yes. All flights to Santa Cruz de la Sierra from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Santa Cruz de la Sierra?

momondo provides multiple filters to help you find the best flight to Santa Cruz de la Sierra from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santa Cruz de la Sierra, momondo offers a useful price alert feature which will track prices for flights to Santa Cruz de la Sierra from San Francisco and alert you when they change.

An easier way to manage your Santa Cruz de la Sierra trip

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