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Cheap flights from San Francisco to Guayaquil from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Guayaquil departing on 7/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:45 pm - 1:31 pm
SFO
-
GYE
16h 46m
2 stops
American Airlines Logo
2:31 pm - 8:34 am
GYE
-
SFO
20h 03m
2 stops
$500American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
10:00 pm - 1:31 pm
SFO
-
GYE
13h 31m
1 stop
American Airlines Logo
6:00 am - 11:59 pm
GYE
-
SFO
19h 59m
1 stop
$516American Airlines
Fri, May 15 - Sun, May 24
Copa Airlines Logo
1:12 am - 5:29 pm
SFO
-
GYE
14h 17m
1 stop
Copa Airlines Logo
12:22 pm - 11:40 pm
GYE
-
SFO
13h 18m
1 stop
$525Copa Airlines
Thu, May 7 - Fri, May 22
Copa Airlines Logo
1:12 am - 5:29 pm
SFO
-
GYE
14h 17m
1 stop
Copa Airlines Logo
2:43 pm - 6:14 pm
GYE
-
SFO
29h 31m
1 stop
$534Copa Airlines
Mon, May 18 - Tue, May 26
Copa Airlines Logo
1:12 am - 1:33 pm
SFO
-
GYE
10h 21m
1 stop
Copa Airlines Logo
6:28 pm - 6:14 pm
GYE
-
SFO
25h 46m
1 stop
$548Copa Airlines
Fri, May 15 - Sat, May 16
JetBlue Logo
2:45 pm - 10:58 am
SFO
-
GYE
18h 13m
1 stop
JetBlue Logo
12:30 pm - 11:51 pm
GYE
-
SFO
13h 21m
1 stop
$549JetBlue
Fri, May 8 - Wed, May 20
American Airlines Logo
6:00 am - 9:12 pm
SFO
-
GYE
13h 12m
2 stops
American Airlines Logo
6:05 am - 10:31 pm
GYE
-
SFO
18h 26m
1 stop
$555American Airlines
Sat, Apr 25 - Fri, May 1
JetBlue Logo
11:05 pm - 2:26 pm
SFO
-
GYE
13h 21m
1 stop
JetBlue Logo
12:25 pm - 11:09 am
GYE
-
SFO
24h 44m
1 stop
$561JetBlue
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
8:13 pm - 1:31 pm
SFO
-
GYE
15h 18m
2 stops
American Airlines Logo
2:31 pm - 8:34 am
GYE
-
SFO
20h 03m
2 stops
$566American Airlines
Mon, May 25 - Tue, Jun 2
GOL Logo
10:35 pm - 9:12 pm
SFO
-
GYE
20h 37m
2 stops
GOL Logo
6:00 am - 11:59 pm
GYE
-
SFO
19h 59m
1 stop
$576GOL
Fri, May 8 - Fri, May 22

Copa Airlines flights from San Francisco to Guayaquil

Our best Copa Airlines deals on San Francisco to Guayaquil flight tickets
Copa Airlines
May 7
SFO1:12 amSan Francisco
14h 17m
1 stop
GYE5:29 pmGuayaquil Jose Joaquin de Olmedo
May 22
GYE12:22 pmGuayaquil Jose Joaquin de Olmedo
13h 18m
1 stop
SFO11:40 pmSan Francisco
$525
Copa Airlines
May 18
SFO1:12 amSan Francisco
14h 17m
1 stop
GYE5:29 pmGuayaquil Jose Joaquin de Olmedo
May 26
GYE2:43 pmGuayaquil Jose Joaquin de Olmedo
29h 31m
1 stop
SFO6:14 pmSan Francisco
$534
Copa Airlines
May 15
SFO1:12 amSan Francisco
10h 21m
1 stop
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
May 16
GYE6:28 pmGuayaquil Jose Joaquin de Olmedo
25h 46m
1 stop
SFO6:14 pmSan Francisco
$548

American Airlines flights from San Francisco to Guayaquil

Our best American Airlines deals on San Francisco to Guayaquil flight tickets
American Airlines
May 19
SFO6:45 pmSan Francisco
16h 46m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
May 26
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
20h 03m
2 stops
SFO8:34 amSan Francisco
$500
American Airlines
May 15
SFO10:00 pmSan Francisco
13h 31m
1 stop
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
May 24
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
19h 59m
1 stop
SFO11:59 pmSan Francisco
$516
American Airlines
Apr 25
SFO6:00 amSan Francisco
13h 12m
2 stops
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
May 1
GYE6:05 amGuayaquil Jose Joaquin de Olmedo
18h 26m
1 stop
SFO10:31 pmSan Francisco
$555

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from San Francisco to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Tue 5/19

6:45 pm-1:31 pm

2 stops16h 46m

Guayaquil Jose Joaquin de Olmedo

Tue 5/26

2:31 pm-8:34 am

2 stops20h 03m

$500

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Fri 5/15

10:00 pm-1:31 pm

1 stop13h 31m

Guayaquil Jose Joaquin de Olmedo

Sun 5/24

6:00 am-11:59 pm

1 stop19h 59m

$516
Quickest round-trip

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Thu 5/7

1:12 am-5:29 pm

1 stop14h 17m

Guayaquil Jose Joaquin de Olmedo

Fri 5/22

12:22 pm-11:40 pm

1 stop13h 18m

$525

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Mon 5/18

1:12 am-5:29 pm

1 stop14h 17m

Guayaquil Jose Joaquin de Olmedo

Tue 5/26

2:43 pm-6:14 pm

1 stop29h 31m

$534

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Fri 5/15

1:12 am-1:33 pm

1 stop10h 21m

Guayaquil Jose Joaquin de Olmedo

Sat 5/16

6:28 pm-6:14 pm

1 stop25h 46m

$548

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Fri 5/8

2:45 pm-10:58 am

1 stop18h 13m

Guayaquil Jose Joaquin de Olmedo

Wed 5/20

12:30 pm-11:51 pm

1 stop13h 21m

$549

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Sat 4/25

6:00 am-9:12 pm

2 stops13h 12m

Guayaquil Jose Joaquin de Olmedo

Fri 5/1

6:05 am-10:31 pm

1 stop18h 26m

$555

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Fri 4/24

11:05 pm-2:26 pm

1 stop13h 21m

Guayaquil Jose Joaquin de Olmedo

Tue 4/28

12:25 pm-11:09 am

1 stop24h 44m

$561

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Mon 5/25

8:13 pm-1:31 pm

2 stops15h 18m

Guayaquil Jose Joaquin de Olmedo

Tue 6/2

2:31 pm-8:34 am

2 stops20h 03m

$566

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Fri 5/8

10:35 pm-9:12 pm

2 stops20h 37m

Guayaquil Jose Joaquin de Olmedo

Fri 5/22

6:00 am-11:59 pm

1 stop19h 59m

$576

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from San Francisco to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Guayaquil?

What is the cheapest month to fly to Guayaquil?

The month of February is another great option to travel to Guayaquil, with average flight prices from San Francisco averaging around $527.

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $627 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from San Francisco for as low as $484 on momondo.

Can stopping save me money on San Francisco to Guayaquil flights?

You could potentially save up to 2% on your flight if you consider stops on a San Francisco to Guayaquil flight.

How have San Francisco to Guayaquil flight prices changed over time?

As of April 2026, prices for San Francisco to Guayaquil flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Guayaquil (SFO to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Guayaquil

Fastest flight time

13h 01m

Direct flights

None
The fastest flight from San Francisco to Guayaquil takes 13h 01m
There are no direct flights from San Francisco to Guayaquil. There are no popular flight routes from San Francisco to Guayaquil.
Search flight deals

Frequently asked questions about flying from San Francisco to Guayaquil

  • How far is San Francisco to Guayaquil Jose Joaquin de Olmedo by plane?

    The straight-line distance from San Francisco to Guayaquil Jose Joaquin de Olmedo is 3868.8 mi. By plane, this route typically takes 13h 01m.

  • When did momondo last update prices for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Guayaquil?

Best airlines flying from San Francisco to Guayaquil

Compare and see reviews for airlines that fly from San Francisco to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $203Free CancellationRating
7.2
2,926 reviews
Search JetBlue flights
Copa AirlinesPriceFrom $387Free CancellationRating
7.5
1,575 reviews
Search Copa Airlines flights
AviancaPriceFrom $432Free CancellationRating
6.5
2,503 reviews
Search Avianca flights
United AirlinesPriceFrom $486Free CancellationRating
7.4
9,560 reviews
Search United Airlines flights
American AirlinesPriceFrom $570Free CancellationRating
7.1
11,562 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Guayaquil?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Guayaquil for you.

Can I find flights from San Francisco to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from San Francisco with this policy.

How can momondo help me find flights from San Francisco to Guayaquil?

Once you have performed a search for San Francisco to Guayaquil flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Guayaquil right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Guayaquil from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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