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Cheap flights from San Francisco to Guayaquil from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Guayaquil departing on 4/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
2:45 pm - 10:58 am
SFO
-
GYE
18h 13m
1 stop
JetBlue Logo
1:15 pm - 12:33 am
GYE
-
SFO
13h 18m
1 stop
$448JetBlue
Tue, Apr 28 - Sat, May 23
JetBlue Logo
11:20 pm - 1:30 pm
SFO
-
GYE
12h 10m
1 stop
JetBlue Logo
9:30 pm - 11:52 am
GYE
-
SFO
16h 22m
1 stop
$452JetBlue
Mon, Sep 21 - Mon, Sep 28
Copa Airlines Logo
8:37 pm - 1:35 pm
SFO
-
GYE
14h 58m
1 stop
Copa Airlines Logo
6:00 am - 11:40 pm
GYE
-
SFO
19h 40m
1 stop
$460Copa Airlines
Wed, Apr 22 - Wed, Apr 29
JetBlue Logo
2:45 pm - 10:58 am
SFO
-
GYE
18h 13m
1 stop
JetBlue Logo
1:15 pm - 12:33 am
GYE
-
SFO
13h 18m
1 stop
$484JetBlue
Tue, Apr 28 - Thu, May 21
American Airlines Logo
11:58 pm - 10:37 pm
SFO
-
GYE
20h 39m
1 stop
American Airlines Logo
6:00 am - 6:41 pm
GYE
-
SFO
14h 41m
1 stop
$495American Airlines
Mon, May 25 - Tue, Jun 2
Copa Airlines Logo
1:12 am - 11:38 pm
SFO
-
GYE
20h 26m
1 stop
Copa Airlines Logo
11:48 am - 11:40 pm
GYE
-
SFO
13h 52m
1 stop
$498Copa Airlines
Sun, Aug 16 - Thu, Aug 20
American Airlines Logo
11:58 pm - 10:37 pm
SFO
-
GYE
20h 39m
1 stop
American Airlines Logo
2:31 pm - 8:34 am
GYE
-
SFO
20h 03m
2 stops
$500American Airlines
Mon, May 25 - Tue, Jun 2
Copa Airlines Logo
8:16 pm - 11:20 am
SFO
-
GYE
13h 04m
1 stop
Copa Airlines Logo
8:28 am - 11:40 pm
GYE
-
SFO
17h 12m
1 stop
$501Copa Airlines
Thu, May 14 - Sun, May 17
GOL Logo
10:28 pm - 9:12 pm
SFO
-
GYE
20h 44m
2 stops
GOL Logo
6:05 am - 11:15 pm
GYE
-
SFO
19h 10m
2 stops
$502GOL
Sun, Apr 19 - Fri, Apr 24
Multiple Airlines Logo
1:12 am - 5:29 pm
SFO
-
GYE
14h 17m
1 stop
Multiple Airlines Logo
10:05 am - 10:35 pm
GYE
-
SFO
14h 30m
2 stops
$514Multiple Airlines
Sun, May 10 - Mon, May 18

Copa Airlines flights from San Francisco to Guayaquil

Our best Copa Airlines deals on San Francisco to Guayaquil flight tickets
Copa Airlines
Apr 22
SFO8:37 pmSan Francisco
14h 58m
1 stop
GYE1:35 pmGuayaquil Jose Joaquin de Olmedo
Apr 29
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
19h 40m
1 stop
SFO11:40 pmSan Francisco
$460
Copa Airlines
Aug 16
SFO1:12 amSan Francisco
20h 26m
1 stop
GYE11:38 pmGuayaquil Jose Joaquin de Olmedo
Aug 20
GYE11:48 amGuayaquil Jose Joaquin de Olmedo
13h 52m
1 stop
SFO11:40 pmSan Francisco
$498
Copa Airlines
May 14
SFO8:16 pmSan Francisco
13h 04m
1 stop
GYE11:20 amGuayaquil Jose Joaquin de Olmedo
May 17
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
17h 12m
1 stop
SFO11:40 pmSan Francisco
$501

American Airlines flights from San Francisco to Guayaquil

Our best American Airlines deals on San Francisco to Guayaquil flight tickets
American Airlines
May 25
SFO11:58 pmSan Francisco
20h 39m
1 stop
GYE10:37 pmGuayaquil Jose Joaquin de Olmedo
Jun 2
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
14h 41m
1 stop
SFO6:41 pmSan Francisco
$495
American Airlines
May 25
SFO11:58 pmSan Francisco
20h 39m
1 stop
GYE10:37 pmGuayaquil Jose Joaquin de Olmedo
Jun 2
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
20h 03m
2 stops
SFO8:34 amSan Francisco
$500
American Airlines
May 25
SFO8:13 pmSan Francisco
15h 18m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
Jun 2
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
20h 03m
2 stops
SFO8:34 amSan Francisco
$566

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from San Francisco to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Tue 4/28

2:45 pm-10:58 am

1 stop18h 13m

Guayaquil Jose Joaquin de Olmedo

Sat 5/23

1:15 pm-12:33 am

1 stop13h 18m

$448
Quickest round-trip

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Mon 9/21

11:20 pm-1:30 pm

1 stop12h 10m

Guayaquil Jose Joaquin de Olmedo

Mon 9/28

9:30 pm-11:52 am

1 stop16h 22m

$452

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Wed 4/22

8:37 pm-1:35 pm

1 stop14h 58m

Guayaquil Jose Joaquin de Olmedo

Wed 4/29

6:00 am-11:40 pm

1 stop19h 40m

$460

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Tue 4/28

2:45 pm-10:58 am

1 stop18h 13m

Guayaquil Jose Joaquin de Olmedo

Thu 5/21

1:15 pm-12:33 am

1 stop13h 18m

$484

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Mon 5/25

11:58 pm-10:37 pm

1 stop20h 39m

Guayaquil Jose Joaquin de Olmedo

Tue 6/2

6:00 am-6:41 pm

1 stop14h 41m

$495

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Sun 8/16

1:12 am-11:38 pm

1 stop20h 26m

Guayaquil Jose Joaquin de Olmedo

Thu 8/20

11:48 am-11:40 pm

1 stop13h 52m

$498

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Mon 5/25

11:58 pm-10:37 pm

1 stop20h 39m

Guayaquil Jose Joaquin de Olmedo

Tue 6/2

2:31 pm-8:34 am

2 stops20h 03m

$500

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Thu 5/14

8:16 pm-11:20 am

1 stop13h 04m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

8:28 am-11:40 pm

1 stop17h 12m

$501

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Sun 4/19

10:28 pm-9:12 pm

2 stops20h 44m

Guayaquil Jose Joaquin de Olmedo

Fri 4/24

6:05 am-11:15 pm

2 stops19h 10m

$502

San FranciscoGuayaquil

SFO - GYE

SFOGYE

San Francisco

Sun 5/10

1:12 am-5:29 pm

1 stop14h 17m

Guayaquil Jose Joaquin de Olmedo

Mon 5/18

10:05 am-10:35 pm

2 stops14h 30m

$514

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from San Francisco to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Guayaquil?

What is the cheapest month to fly to Guayaquil?

The month of February is another great option to travel to Guayaquil, with average flight prices from San Francisco averaging around $527.

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $625 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from San Francisco for as low as $484 on momondo.

Can stopping save me money on San Francisco to Guayaquil flights?

You could potentially save up to 2% on your flight if you consider stops on a San Francisco to Guayaquil flight.

How have San Francisco to Guayaquil flight prices changed over time?

As of March 2026, prices for San Francisco to Guayaquil flights are approximately 16% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Guayaquil (SFO to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Guayaquil

Fastest flight time

13h 04m

Direct flights

None
The fastest flight from San Francisco to Guayaquil takes 13h 04m
There are no direct flights from San Francisco to Guayaquil. There are no popular flight routes from San Francisco to Guayaquil.
Search flight deals

  • How far is San Francisco to Guayaquil Jose Joaquin de Olmedo by plane?

    The straight-line distance from San Francisco to Guayaquil Jose Joaquin de Olmedo is 3868.8 mi. By plane, this route typically takes 13h 04m.

  • When did momondo last update prices for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Guayaquil?

Best airlines flying from San Francisco to Guayaquil

Compare and see reviews for airlines that fly from San Francisco to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $203Free CancellationRating
7.2
2,909 reviews
Search JetBlue flights
AviancaPriceFrom $352Free CancellationRating
6.5
2,506 reviews
Search Avianca flights
Copa AirlinesPriceFrom $387Free CancellationRating
7.5
1,579 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $486Free CancellationRating
7.4
9,493 reviews
Search United Airlines flights
American AirlinesPriceFrom $570Free CancellationRating
7.1
11,509 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Guayaquil?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Guayaquil for you.

Can I find flights from San Francisco to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from San Francisco with this policy.

How can momondo help me find flights from San Francisco to Guayaquil?

Once you have performed a search for San Francisco to Guayaquil flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Francisco to Guayaquil right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Guayaquil from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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