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Cheap flights from Roanoke to Panama City from $481

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama City departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:48 am - 4:04 am
ROA
-
PTY
18h 16m
2 stops
United Airlines Logo
3:30 pm - 10:13 am
PTY
-
ROA
17h 43m
2 stops
$481United Airlines
Tue, Apr 21 - Fri, Apr 24
Copa Airlines Logo
6:00 am - 7:31 pm
ROA
-
PTY
14h 31m
2 stops
Copa Airlines Logo
3:30 pm - 10:16 am
PTY
-
ROA
17h 46m
2 stops
$485Copa Airlines
Thu, Apr 30 - Sat, May 9
United Airlines Logo
7:59 pm - 2:14 pm
ROA
-
PTY
19h 15m
2 stops
United Airlines Logo
10:00 am - 9:49 am
PTY
-
ROA
22h 49m
2 stops
$501United Airlines
Sat, Apr 11 - Sun, Apr 19
Delta Logo
6:00 am - 1:03 pm
ROA
-
PTY
8h 03m
1 stop
Delta Logo
2:27 pm - 12:25 am
PTY
-
ROA
8h 58m
1 stop
$577Delta
Sat, Apr 11 - Sun, Apr 19
LATAM Airlines Logo
6:00 am - 1:02 pm
ROA
-
PTY
8h 02m
1 stop
LATAM Airlines Logo
2:20 pm - 10:35 am
PTY
-
ROA
19h 15m
1 stop
$605LATAM Airlines
Thu, Apr 30 - Sat, May 9
LATAM Airlines Logo
6:00 am - 1:02 pm
ROA
-
PTY
8h 02m
1 stop
LATAM Airlines Logo
2:27 pm - 7:01 pm
PTY
-
ROA
27h 34m
1 stop
$780LATAM Airlines
Tue, Apr 21 - Fri, Apr 24
Delta Logo
6:00 am - 1:02 pm
ROA
-
PTY
8h 02m
1 stop
Delta Logo
2:27 pm - 12:25 am
PTY
-
ROA
8h 58m
1 stop
$872Delta
Tue, Apr 21 - Fri, Apr 24
American Airlines Logo
7:33 pm - 12:36 pm
ROA
-
PTY
18h 03m
2 stops
American Airlines Logo
1:49 pm - 8:36 am
PTY
-
ROA
17h 47m
3 stops
$2,301American Airlines
Tue, Apr 21 - Fri, Apr 24
American Airlines Logo
7:45 pm - 12:36 pm
ROA
-
PTY
17h 51m
3 stops
American Airlines Logo
1:49 pm - 8:36 am
PTY
-
ROA
17h 47m
2 stops
$2,306American Airlines
Sat, Apr 11 - Sun, Apr 19
Avianca Logo
7:59 pm - 2:55 pm
ROA
-
PTY
19h 56m
3 stops
Avianca Logo
11:25 am - 7:10 pm
PTY
-
ROA
30h 45m
3 stops
$3,105Avianca
Thu, Apr 30 - Sat, May 9

Delta flights from Roanoke to Panama City

Our best Delta deals on Roanoke to Panama City flight tickets
Delta
Apr 11
ROA6:00 amRoanoke
8h 03m
1 stop
PTY1:03 pmPanama City Tocumen Intl
Apr 19
PTY2:27 pmPanama City Tocumen Intl
8h 58m
1 stop
ROA12:25 amRoanoke
$577
Delta
Feb 4
ROA6:00 amRoanoke
7h 55m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Feb 8
PTY3:20 pmPanama City Tocumen Intl
8h 44m
1 stop
ROA12:04 amRoanoke
$752
Delta
Apr 21
ROA6:00 amRoanoke
8h 02m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Apr 24
PTY2:27 pmPanama City Tocumen Intl
8h 58m
1 stop
ROA12:25 amRoanoke
$872

United Airlines flights from Roanoke to Panama City

Our best United Airlines deals on Roanoke to Panama City flight tickets
United Airlines
Apr 21
ROA10:48 amRoanoke
18h 16m
2 stops
PTY4:04 amPanama City Tocumen Intl
Apr 24
PTY3:30 pmPanama City Tocumen Intl
17h 43m
2 stops
ROA10:13 amRoanoke
$481
United Airlines
Apr 11
ROA7:59 pmRoanoke
19h 15m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Apr 19
PTY10:00 amPanama City Tocumen Intl
22h 49m
2 stops
ROA9:49 amRoanoke
$501
United Airlines
Jan 31
ROA5:39 pmRoanoke
21h 06m
2 stops
PTY2:45 pmPanama City Tocumen Intl
Mar 1
PTY4:41 pmPanama City Tocumen Intl
28h 08m
2 stops
ROA8:49 pmRoanoke
$543

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Roanoke to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 4/21

10:48 am-4:04 am

2 stops18h 16m

Panama City Tocumen Intl

Fri 4/24

3:30 pm-10:13 am

2 stops17h 43m

$481

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 4/30

6:00 am-7:31 pm

2 stops14h 31m

Panama City Tocumen Intl

Sat 5/9

3:30 pm-10:16 am

2 stops17h 46m

$485

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 4/11

7:59 pm-2:14 pm

2 stops19h 15m

Panama City Tocumen Intl

Sun 4/19

10:00 am-9:49 am

2 stops22h 49m

$501

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 4/11

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Sun 4/19

2:27 pm-12:25 am

1 stop8h 58m

$577

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 4/30

6:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Sat 5/9

2:20 pm-10:35 am

1 stop19h 15m

$605

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 4/21

6:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Fri 4/24

2:27 pm-7:01 pm

1 stop27h 34m

$780

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 4/21

6:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Fri 4/24

2:27 pm-12:25 am

1 stop8h 58m

$872

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 4/21

7:33 pm-12:36 pm

2 stops18h 03m

Panama City Tocumen Intl

Fri 4/24

1:49 pm-8:36 am

3 stops17h 47m

$2,301

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 4/11

7:45 pm-12:36 pm

3 stops17h 51m

Panama City Tocumen Intl

Sun 4/19

1:49 pm-8:36 am

2 stops17h 47m

$2,306

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 4/30

7:59 pm-2:55 pm

3 stops19h 56m

Panama City Tocumen Intl

Sat 5/9

11:25 am-7:10 pm

3 stops30h 45m

$3,105

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Roanoke to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Roanoke to Panama City flights?

You could potentially save up to 5% on your flight if you consider stops on a Roanoke to Panama City flight.

When to book flights from Roanoke to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Panama City (ROA to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama City

Fastest flight time

18h 16m

Direct flights

None
The fastest flight from Roanoke to Panama City takes 18h 16m
There are no direct flights from Roanoke to Panama City. There are no popular flight routes from Roanoke to Panama City.
Search flight deals

  • How far is Roanoke to Panama City Tocumen Intl by plane?

    Roanoke and Panama City Tocumen Intl are 1953.3 mi apart from one another. Flights usually cover this in 18h 16m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Roanoke Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Roanoke Airport to Panama City Tocumen Intl Airport refresh daily.

  • How old do you have to be to fly from Roanoke Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Roanoke Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Roanoke to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Roanoke to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Roanoke which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Roanoke to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Roanoke to Panama City.

I’m not ready to book a flight from Roanoke to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Roanoke to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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