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Cheap flights from Roanoke to Panama City from $516

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama City departing on 11/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Delta Logo
6:00 am - 1:56 pmROA-PTY
7h 56m1 stop
Delta Logo
3:21 pm - 12:09 amPTY-ROA
8h 48m1 stop
$516Delta
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Mon, Nov 3 - Tue, Nov 4
United Airlines Logo
3:00 pm - 2:45 pmROA-PTY
23h 45m2 stops
United Airlines Logo
4:41 pm - 11:59 amPTY-ROA
19h 18m2 stops
$517United Airlines
Find Deal
Mon, Nov 10 - Wed, Nov 12
Delta Logo
6:00 am - 1:56 pmROA-PTY
7h 56m1 stop
Delta Logo
3:21 pm - 10:45 pmPTY-ROA
31h 24m2 stops
$520Delta
Find Deal
Mon, Nov 3 - Wed, Nov 5
United Airlines Logo
10:26 am - 1:45 pmROA-PTY
28h 19m2 stops
United Airlines Logo
4:41 pm - 4:56 pmPTY-ROA
24h 15m2 stops
$522United Airlines
Find Deal
Fri, Oct 31 - Wed, Nov 5
Delta Logo
6:00 am - 1:56 pmROA-PTY
7h 56m1 stop
Delta Logo
3:21 pm - 12:09 amPTY-ROA
8h 48m1 stop
$536Delta
Find Deal
Mon, Nov 3 - Fri, Nov 7
United Airlines Logo
10:26 am - 2:45 pmROA-PTY
28h 19m2 stops
United Airlines Logo
4:41 pm - 11:59 amPTY-ROA
19h 18m2 stops
$537United Airlines
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Sun, Nov 2 - Tue, Nov 4
Avianca Logo
7:50 pm - 2:55 pmROA-PTY
19h 05m3 stops
Avianca Logo
3:50 pm - 6:43 pmPTY-ROA
26h 53m2 stops
$1,101Avianca
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Mon, Nov 3 - Fri, Nov 7
Avianca Logo
7:50 pm - 2:55 pmROA-PTY
20h 05m3 stops
Avianca Logo
3:50 pm - 6:43 pmPTY-ROA
26h 53m2 stops
$1,135Avianca
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Sat, Nov 1 - Fri, Nov 7
Multiple Airlines Logo
7:50 pm - 10:30 amROA-PTY
14h 40m2 stops
Multiple Airlines Logo
2:55 am - 6:56 pmPTY-ROA
16h 01m2 stops
$1,263Multiple Airlines
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Fri, Nov 28 - Thu, Dec 4
Multiple Airlines Logo
7:50 pm - 10:30 amROA-PTY
14h 40m2 stops
Multiple Airlines Logo
2:55 am - 6:43 pmPTY-ROA
15h 48m2 stops
$1,855Multiple Airlines
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Mon, Nov 3 - Tue, Nov 4

Delta flights from Roanoke to Panama City

Our best Delta deals on Roanoke to Panama City flight tickets
Delta
Nov 3
ROA6:00 amRoanoke
7h 56m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 4
PTY3:21 pmPanama City Tocumen Intl
8h 48m
1 stop
ROA12:09 amRoanoke
$516
Find similar
Delta
Nov 3
ROA6:00 amRoanoke
7h 56m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 5
PTY3:21 pmPanama City Tocumen Intl
31h 24m
2 stops
ROA10:45 pmRoanoke
$520
Find similar
Delta
Nov 3
ROA6:00 amRoanoke
7h 56m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 7
PTY3:21 pmPanama City Tocumen Intl
8h 48m
1 stop
ROA12:09 amRoanoke
$536
Find similar

United Airlines flights from Roanoke to Panama City

Our best United Airlines deals on Roanoke to Panama City flight tickets
United Airlines
Nov 10
ROA3:00 pmRoanoke
23h 45m
2 stops
PTY2:45 pmPanama City Tocumen Intl
Nov 12
PTY4:41 pmPanama City Tocumen Intl
19h 18m
2 stops
ROA11:59 amRoanoke
$517
Find similar
United Airlines
Oct 31
ROA10:26 amRoanoke
28h 19m
2 stops
PTY1:45 pmPanama City Tocumen Intl
Nov 5
PTY4:41 pmPanama City Tocumen Intl
24h 15m
2 stops
ROA4:56 pmRoanoke
$522
Find similar
United Airlines
Nov 2
ROA10:26 amRoanoke
28h 19m
2 stops
PTY2:45 pmPanama City Tocumen Intl
Nov 4
PTY4:41 pmPanama City Tocumen Intl
19h 18m
2 stops
ROA11:59 amRoanoke
$537
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Roanoke to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 11/4

3:21 pm-12:09 am

1 stop8h 48m

$516

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/10

3:00 pm-2:45 pm

2 stops23h 45m

Panama City Tocumen Intl

Wed 11/12

4:41 pm-11:59 am

2 stops19h 18m

$517

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Wed 11/5

3:21 pm-10:45 pm

2 stops31h 24m

$520

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 10/31

10:26 am-1:45 pm

2 stops28h 19m

Panama City Tocumen Intl

Wed 11/5

4:41 pm-4:56 pm

2 stops24h 15m

$522

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Fri 11/7

3:21 pm-12:09 am

1 stop8h 48m

$536

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 11/2

10:26 am-2:45 pm

2 stops28h 19m

Panama City Tocumen Intl

Tue 11/4

4:41 pm-11:59 am

2 stops19h 18m

$537

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

7:50 pm-2:55 pm

3 stops19h 05m

Panama City Tocumen Intl

Fri 11/7

3:50 pm-6:43 pm

2 stops26h 53m

$1,101

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 11/1

7:50 pm-2:55 pm

3 stops20h 05m

Panama City Tocumen Intl

Fri 11/7

3:50 pm-6:43 pm

2 stops26h 53m

$1,135

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/28

7:50 pm-10:30 am

2 stops14h 40m

Panama City Tocumen Intl

Thu 12/4

2:55 am-6:56 pm

2 stops16h 01m

$1,263

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

7:50 pm-10:30 am

2 stops14h 40m

Panama City Tocumen Intl

Tue 11/4

2:55 am-6:43 pm

2 stops15h 48m

$1,855

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Roanoke to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $437. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $643. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

When to book flights from Roanoke to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Panama City (ROA to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama City

Direct flights

None
There are no direct flights from Roanoke to Panama City. There are no popular flight routes from Roanoke to Panama City.
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  • How far is Roanoke to Panama City Tocumen Intl by plane?

    Roanoke and Panama City Tocumen Intl are 1953.3 mi apart from one another. Flights usually cover this in 7h 56m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Roanoke Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Roanoke Airport to Panama City Tocumen Intl Airport refresh daily.

  • How old do you have to be to fly from Roanoke Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Roanoke Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Roanoke to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Roanoke to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Roanoke which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Roanoke to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Roanoke to Panama City.

I’m not ready to book a flight from Roanoke to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Roanoke to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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