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Cheap flights from Panama to Chicago from $245

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to Chicago departing on 2/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama to Chicago

Recent round-trip flight deals from Panama to Chicago

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:50 pm - 9:39 am
PTY
-
ORD
16h 49m2 stops
Multiple Airlines Logo
7:13 pm - 8:06 am
ORD
-
PTY
11h 53m1 stop
$493Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
9:33 pm - 9:39 am
PTY
-
ORD
13h 06m1 stop
Multiple Airlines Logo
7:13 pm - 8:50 am
ORD
-
PTY
12h 37m2 stops
$494Multiple Airlines
Sun, Feb 22 - Wed, Mar 4
Multiple Airlines Logo
9:33 pm - 9:39 am
PTY
-
ORD
13h 06m1 stop
Multiple Airlines Logo
7:13 pm - 8:06 am
ORD
-
PTY
11h 53m1 stop
$509Multiple Airlines
Sun, Feb 22 - Wed, Mar 4
Multiple Airlines Logo
2:55 am - 9:13 pm
PTY
-
ORD
19h 18m2 stops
Multiple Airlines Logo
11:33 am - 8:37 pm
ORD
-
PTY
8h 04m1 stop
$517Multiple Airlines
Fri, Feb 20 - Mon, Mar 2
Multiple Airlines Logo
9:33 pm - 10:38 am
PTY
-
ORD
14h 05m1 stop
Multiple Airlines Logo
7:13 pm - 8:50 am
ORD
-
PTY
12h 37m2 stops
$518Multiple Airlines
Fri, Feb 13 - Fri, Feb 27
Multiple Airlines Logo
2:55 am - 7:50 pm
PTY
-
ORD
17h 55m2 stops
Multiple Airlines Logo
7:13 pm - 8:06 am
ORD
-
PTY
11h 53m1 stop
$522Multiple Airlines
Fri, Feb 20 - Tue, Mar 3
Multiple Airlines Logo
5:50 pm - 9:39 am
PTY
-
ORD
16h 49m2 stops
Multiple Airlines Logo
9:18 am - 7:20 pm
ORD
-
PTY
9h 02m1 stop
$525Multiple Airlines
Tue, Feb 24 - Sun, Mar 1
Multiple Airlines Logo
9:33 pm - 9:39 am
PTY
-
ORD
13h 06m1 stop
Multiple Airlines Logo
9:18 am - 1:00 am
ORD
-
PTY
14h 42m2 stops
$526Multiple Airlines
Sun, Feb 22 - Sun, Mar 1
Multiple Airlines Logo
5:50 pm - 8:18 am
PTY
-
ORD
15h 28m2 stops
Multiple Airlines Logo
9:23 am - 7:20 pm
ORD
-
PTY
8h 57m1 stop
$527Multiple Airlines
Thu, Jan 22 - Wed, Jan 28
Multiple Airlines Logo
5:50 pm - 8:18 am
PTY
-
ORD
15h 28m2 stops
Multiple Airlines Logo
10:20 pm - 8:50 am
ORD
-
PTY
9h 30m1 stop
$535Multiple Airlines
Mon, Feb 9 - Sun, Feb 15

American Airlines flights from Panama to Chicago O'Hare Intl Airport

Our best American Airlines deals on Panama to Chicago O'Hare Intl Airport flight tickets
American Airlines
Feb 12
PTY4:05 pmPanama City Tocumen Intl
16h 15m
2 stops
ORD7:20 amChicago O'Hare Intl
Aug 6
ORD6:49 amChicago O'Hare Intl
7h 31m
1 stop
PTY2:20 pmPanama City Tocumen Intl
$586
Find similar
American Airlines
May 2
PTY1:55 pmPanama City Tocumen Intl
17h 15m
2 stops
ORD7:10 amChicago O'Hare Intl
May 10
ORD5:00 amChicago O'Hare Intl
7h 15m
1 stop
PTY12:15 pmPanama City Tocumen Intl
$599
Find similar
American Airlines
Feb 12
PTY2:50 pmPanama City Tocumen Intl
17h 30m
2 stops
ORD7:20 amChicago O'Hare Intl
Aug 6
ORD6:49 amChicago O'Hare Intl
7h 31m
1 stop
PTY2:20 pmPanama City Tocumen Intl
$600
Find similar

Avianca flights from Panama to Chicago O'Hare Intl Airport

Our best Avianca deals on Panama to Chicago O'Hare Intl Airport flight tickets
Avianca
Jan 14
PTY9:45 amPanama City Tocumen Intl
11h 35m
1 stop
ORD8:20 pmChicago O'Hare Intl
Jan 25
ORD10:20 pmChicago O'Hare Intl
14h 40m
1 stop
PTY2:00 pmPanama City Tocumen Intl
$555
Find similar
Avianca
Feb 12
PTY9:45 amPanama City Tocumen Intl
11h 35m
1 stop
ORD8:20 pmChicago O'Hare Intl
Aug 6
ORD2:35 pmChicago O'Hare Intl
19h 35m
1 stop
PTY10:10 amPanama City Tocumen Intl
$558
Find similar
Avianca
Jan 12
PTY7:50 pmPanama City Tocumen Intl
20h 00m
1 stop
ORD2:50 pmChicago O'Hare Intl
Jan 14
ORD10:20 pmChicago O'Hare Intl
17h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$573
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Panama to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 2/24

5:50 pm-9:39 am

2 stops16h 49m

Chicago O'Hare Intl

Tue 3/3

7:13 pm-8:06 am

1 stop11h 53m

$493

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 2/22

9:33 pm-9:39 am

1 stop13h 06m

Chicago O'Hare Intl

Wed 3/4

7:13 pm-8:50 am

2 stops12h 37m

$494

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 2/22

9:33 pm-9:39 am

1 stop13h 06m

Chicago O'Hare Intl

Wed 3/4

7:13 pm-8:06 am

1 stop11h 53m

$509

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 2/20

2:55 am-9:13 pm

2 stops19h 18m

Chicago O'Hare Intl

Mon 3/2

11:33 am-8:37 pm

1 stop8h 04m

$517

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 2/13

9:33 pm-10:38 am

1 stop14h 05m

Chicago O'Hare Intl

Fri 2/27

7:13 pm-8:50 am

2 stops12h 37m

$518

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 2/20

2:55 am-7:50 pm

2 stops17h 55m

Chicago O'Hare Intl

Tue 3/3

7:13 pm-8:06 am

1 stop11h 53m

$522

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 2/24

5:50 pm-9:39 am

2 stops16h 49m

Chicago O'Hare Intl

Sun 3/1

9:18 am-7:20 pm

1 stop9h 02m

$525

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 2/22

9:33 pm-9:39 am

1 stop13h 06m

Chicago O'Hare Intl

Sun 3/1

9:18 am-1:00 am

2 stops14h 42m

$526

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 1/22

5:50 pm-8:18 am

2 stops15h 28m

Chicago O'Hare Intl

Wed 1/28

9:23 am-7:20 pm

1 stop8h 57m

$527

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 2/9

5:50 pm-8:18 am

2 stops15h 28m

Chicago O'Hare Intl

Sun 2/15

10:20 pm-8:50 am

1 stop9h 30m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of March is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Panama averaging around $479.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Wednesday when prices can be found for as low as $493. This is often the case because there is less demand to fly during this day of the week. On the other hand, Tuesday is the most expensive day to depart from Panama because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $799.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Panama in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $532 when looking at flights departing in the afternoon. Try not to purchase tickets in the morning because they tend to be around $679. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Panama to Chicago O'Hare Intl flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $568 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Panama for as low as $463 on momondo.

What cabin class options are available on Panama to Chicago O'Hare Intl flights?

There are 2 cabin classes available to choose from on Panama to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to Chicago O'Hare Intl Airport flights?

No. A direct flight is the cheapest option for a flight between Panama to Chicago O'Hare Intl Airport.

Cheap Panama to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to Chicago O'Hare Intl Airport

Best Price Found

$552

Fastest flight time

5h 36m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Panama in the past 72 hours is $552. The best round-trip flight deal from Panama to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $597.
The fastest flight from Panama to Chicago O'Hare Intl Airport takes 5h 36m
Direct flights go from Panama to Chicago O'Hare Intl Airport every day.
Search flight deals

  • When did momondo last update prices for flights from Panama to Chicago O'Hare Intl Airport?

    Prices for flights from Panama to Chicago O'Hare Intl Airport are updated daily.

  • How many operators does momondo search for flights from Panama to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Panama to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Panama to Chicago O'Hare Intl Airport?

Best airlines flying from Panama to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Panama to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $405Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $423Free CancellationRating
7.4
9,106 reviews
Search United Airlines flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
South Haven
Rockford
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Orland Park
Racine
Hammond
Janesville
Tinley Park
Aurora
Elgin
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Panama to Chicago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama to Chicago. momondo saves you time and could save you money on your trip.

Can I find flights from Panama to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Panama. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama to Chicago right now. Can momondo alert me if prices change?

Price alerts on flights to Chicago from Panama are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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