Cheap flights from Panama to Houston from $351

The month of June is, on average, the cheapest month to fly to Houston George Bush Intcntl Airport from Panama, with most prices found around $681. If you are unable to visit Houston George Bush Intcntl Airport during the month of June, then departing from Panama during the month March is also very affordable. Most momondo users find prices during this month for around $818.

The cheapest day to depart from Panama to Houston George Bush Intcntl Airport is on a Tuesday. Travelers who choose to depart for Houston George Bush Intcntl Airport on a Tuesday will often find tickets for as low as $745. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Houston George Bush Intcntl Airport on Sunday is $859.

Our data shows that the cheapest Panama to Houston George Bush Intcntl Airport flights are usually those with departure times in the afternoon. Our users have found flights to Houston George Bush Intcntl Airport in the afternoon for as low as $747. Try not to purchase tickets in the morning because they tend to be around $767. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Panama City Tocumen Intl to Houston George Bush Intcntl for the best Panama - Houston George Bush Intcntl flight prices

There are 3 cabin classes available to choose from on Panama to Houston George Bush Intcntl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 42% on your flight if you consider stops on a Panama to Houston George Bush Intcntl Airport flight.

Historically, on average around 5% of flights between Panama and Houston have experienced a delay on any given week. The average delay length over the past 12 months has been 138 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 5% of their flights experiencing any sort of delay.

As of September 2026, 4 flights take off from Panama and land in Houston George Bush Intcntl Airport each day. The most common flight departure time for this route is 10:00AM, with 50% of daily flights taking off at noon.

The number of flights available between Panama and Houston George Bush Intcntl Airport is 28 per week as of September 2026. The most frequent departure day is Mon, with 14% of weekly flights leaving on this day.