Cheap flights from Panama City to Madrid from $522

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Madrid departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
KLM Logo
6:50 pm - 9:30 am
PTY
-
MAD
31h 40m1 stop
KLM Logo
1:05 pm - 4:50 pm
MAD
-
PTY
34h 45m1 stop
$709KLM
Thu, May 21 - Tue, Jun 2
Turkish Airlines Logo
10:15 pm - 10:40 pm
PTY
-
MAD
41h 25m1 stop
Turkish Airlines Logo
12:00 pm - 8:20 pm
MAD
-
PTY
39h 20m1 stop
$713Turkish Airlines
Sat, May 16 - Fri, May 29
Air Europa Logo
9:30 pm - 1:05 pm
PTY
-
MAD
9h 35mnonstop
Air Europa Logo
3:10 pm - 7:45 pm
MAD
-
PTY
10h 35mnonstop
$714Air Europa
Fri, Mar 6 - Fri, Mar 20
Multiple Airlines Logo
10:05 pm - 10:15 am
PTY
-
MAD
30h 10m1 stop
Multiple Airlines Logo
6:00 am - 8:10 pm
MAD
-
PTY
20h 10m1 stop
$717Multiple Airlines
Mon, Feb 23 - Sun, Mar 8
Avianca Logo
3:55 am - 4:35 am
PTY
-
MAD
18h 40m1 stop
Avianca Logo
1:20 am - 4:55 pm
MAD
-
PTY
21h 35m1 stop
$723Avianca
Sat, Mar 7 - Sat, Mar 14
Air Europa Logo
9:30 pm - 1:05 pm
PTY
-
MAD
9h 35mnonstop
Air Europa Logo
3:10 pm - 7:45 pm
MAD
-
PTY
10h 35mnonstop
$725Air Europa
Fri, Mar 6 - Fri, Mar 20
Turkish Airlines Logo
10:15 pm - 1:35 pm
PTY
-
MAD
32h 20m1 stop
Turkish Airlines Logo
7:30 am - 6:30 pm
MAD
-
PTY
42h 00m2 stops
$726Turkish Airlines
Wed, Apr 22 - Fri, May 8
Turkish Airlines Logo
9:45 pm - 1:20 pm
PTY
-
MAD
33h 35m1 stop
Turkish Airlines Logo
2:25 pm - 5:05 pm
MAD
-
PTY
32h 40m2 stops
$727Turkish Airlines
Wed, Mar 11 - Mon, Mar 16
Turkish Airlines Logo
10:15 pm - 10:40 pm
PTY
-
MAD
41h 25m1 stop
Turkish Airlines Logo
7:30 am - 8:20 pm
MAD
-
PTY
19h 50m1 stop
$728Turkish Airlines
Sat, May 9 - Sat, Jun 13
KLM Logo
10:05 pm - 11:25 pm
PTY
-
MAD
19h 20m1 stop
KLM Logo
4:50 pm - 4:30 pm
MAD
-
PTY
29h 40m1 stop
$729KLM
Mon, Feb 2 - Mon, Feb 16

Turkish Airlines flights from Panama City to Madrid

Our best Turkish Airlines deals on Panama City to Madrid flight tickets
Turkish Airlines
May 16
PTY10:15 pmPanama City Tocumen Intl
41h 25m
1 stop
MAD10:40 pmMadrid Barajas
May 29
MAD12:00 pmMadrid Barajas
39h 20m
1 stop
PTY8:20 pmPanama City Tocumen Intl
Turkish Airlines
Apr 22
PTY10:15 pmPanama City Tocumen Intl
32h 20m
1 stop
MAD1:35 pmMadrid Barajas
May 8
MAD7:30 amMadrid Barajas
42h 00m
2 stops
PTY6:30 pmPanama City Tocumen Intl
Turkish Airlines
Mar 11
PTY9:45 pmPanama City Tocumen Intl
30h 40m
1 stop
MAD10:25 amMadrid Barajas
Mar 16
MAD5:55 pmMadrid Barajas
29h 10m
2 stops
PTY5:05 pmPanama City Tocumen Intl

Avianca flights from Panama City to Madrid

Our best Avianca deals on Panama City to Madrid flight tickets
Avianca
Mar 7
PTY3:55 amPanama City Tocumen Intl
18h 40m
1 stop
MAD4:35 amMadrid Barajas
Mar 14
MAD1:20 amMadrid Barajas
21h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
Avianca
Feb 5
PTY2:55 amPanama City Tocumen Intl
14h 25m
1 stop
MAD11:20 pmMadrid Barajas
Mar 7
MAD1:20 amMadrid Barajas
13h 30m
1 stop
PTY8:50 amPanama City Tocumen Intl
Avianca
Jan 24
PTY5:50 pmPanama City Tocumen Intl
13h 35m
1 stop
MAD1:25 pmMadrid Barajas
Feb 22
MAD6:35 amMadrid Barajas
13h 25m
1 stop
PTY2:00 pmPanama City Tocumen Intl

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 5/21

6:50 pm-9:30 am

1 stop31h 40m

Madrid Barajas

Tue 6/2

1:05 pm-4:50 pm

1 stop34h 45m

$709

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/16

10:15 pm-10:40 pm

1 stop41h 25m

Madrid Barajas

Fri 5/29

12:00 pm-8:20 pm

1 stop39h 20m

$713

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 3/6

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Fri 3/20

3:10 pm-7:45 pm

Nonstop10h 35m

$714

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/23

10:05 pm-10:15 am

1 stop30h 10m

Madrid Barajas

Sun 3/8

6:00 am-8:10 pm

1 stop20h 10m

$717

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 3/7

3:55 am-4:35 am

1 stop18h 40m

Madrid Barajas

Sat 3/14

1:20 am-4:55 pm

1 stop21h 35m

$723

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 3/6

9:30 pm-1:05 pm

Nonstop9h 35m

Madrid Barajas

Fri 3/20

3:10 pm-7:45 pm

Nonstop10h 35m

$725

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/22

10:15 pm-1:35 pm

1 stop32h 20m

Madrid Barajas

Fri 5/8

7:30 am-6:30 pm

2 stops42h 00m

$726

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/11

9:45 pm-1:20 pm

1 stop33h 35m

Madrid Barajas

Mon 3/16

2:25 pm-5:05 pm

2 stops32h 40m

$727

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/9

10:15 pm-10:40 pm

1 stop41h 25m

Madrid Barajas

Sat 6/13

7:30 am-8:20 pm

1 stop19h 50m

$728

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/2

10:05 pm-11:25 pm

1 stop19h 20m

Madrid Barajas

Mon 2/16

4:50 pm-4:30 pm

1 stop29h 40m

$729

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Madrid from

How to get the cheapest flight ticket from Panama City to Madrid

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Madrid?

The month of March is, on average, the cheapest month to fly to Madrid from Panama City, with most prices found around $709. If you don’t want to visit Madrid in March, then you should wait until May to fly from Panama City, when ticket prices are also cheap, with an average price of $709.

What is the cheapest day to depart on your flight to Madrid?

The cheapest day to depart on your flight to Madrid is on a Wednesday when prices can be found for as low as $849. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Madrid on Sunday is $896.

What is the cheapest time of day to depart on your flight to Madrid?

Flying to Madrid from Panama City in the morning is the least expensive time of day to depart. momondo users have found prices as low as $751 when looking at flights departing in the morning. Flights to Madrid are more costly at noon, with an average ticket price of $920. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Panama City Tocumen Intl to Madrid Barajas flight route?

Fly from Panama City Tocumen Intl to Madrid Barajas for the best Panama City Tocumen Intl - Madrid Barajas flight prices

How far in advance should I book a flight to Madrid?

You are more likely to see cheaper flights to Madrid from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Madrid for around $784 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Madrid from Panama City for as low as $727 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Madrid Barajas flights?

There are 3 cabin classes available to choose from on Panama City Tocumen Intl to Madrid Barajas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Madrid flights?

No. A direct flight is the cheapest option for a flight between Panama City to Madrid.

How have Panama City to Madrid flight prices changed over time?

As of December 2025, prices for Panama City to Madrid flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Madrid

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Madrid according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Madrid (PTY to MAD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Madrid

Best Price Found

$659

Fastest flight time

9h 35m

Direct flights

Every day

Airports in Madrid

1 airport
The best one-way flight to Madrid from Panama City in the past 72 hours is $659. The best round-trip flight deal from Panama City to Madrid found on momondo in the last 72 hours is $784.
The fastest flight from Panama City to Madrid takes 9h 35m
Direct flights go from Panama City to Madrid every day.
There is 1 airport in Madrid. From Panama City there are direct flights to Madrid Barajas (MAD).
  • How far is Panama City Tocumen Intl to Madrid Barajas by plane?

    The distance between Panama City Tocumen Intl and Madrid Barajas is about 5069.0 mi. Typically, this will take 9h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Madrid Barajas Airport.

  • What documentation or ID do you need to fly to Madrid Barajas Airport?

    The necessary travel and health documents for your Madrid Barajas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Madrid?

  • What is the most popular airline from Panama City to Madrid?

Best airlines flying from Panama City to Madrid

Compare and see reviews for airlines that fly from Panama City to Madrid with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $614Free CancellationRating
6.6
2,487 reviews
Search Avianca flights
KLMPriceFrom $654Free CancellationRating
7.7
1,430 reviews
Search KLM flights
Air EuropaPriceFrom $665Free CancellationRating
7.0
572 reviews
Search Air Europa flights
IberiaPriceFrom $676Free CancellationRating
7.0
3,051 reviews
Search Iberia flights
Air FrancePriceFrom $697Free CancellationRating
7.4
1,506 reviews
Search Air France flights
Turkish AirlinesPriceFrom $698Free CancellationRating
7.3
4,104 reviews
Search Turkish Airlines flights
United AirlinesPriceFrom $700Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $728Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
  • Copa Airlines Flights From Panama City to Madrid

    Across 10 Copa Airlines flights from Panama City to Madrid this week, the average price was $1,269, with the best Copa Airlines deals starting from $728 round-trip. 1,556 users have rated Copa Airlines on momondo, with an average score of 7.6/10.

  • Air Europa Flights From Panama City to Madrid

    Another popular option for Panama City to Madrid flights is Air Europa (7.0/10, 572 ratings). Air Europa flies from Panama City to Madrid around 6 times per week, with deals starting from $665 round-trip and rising to an average price of around $822.

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Toledo
Segovia
Getafe
Fuenlabrada
Cuenca
San Lorenzo de El Escorial
Guadalajara

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Madrid?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Madrid. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Madrid with flexible booking policies on momondo?

Flights from Panama City to Madrid with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Madrid?

momondo helps you find the best flight between Panama City and Madrid by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Madrid right now. Can momondo alert me if prices change?

Price alerts on flights to Madrid from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Fri 1/16
Fri 1/23

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