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Cheap flights from Panama City to Madrid from $403

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Madrid departing on 10/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Turkish Airlines Logo
9:45 pm - 4:25 pmPTY-MAD
36h 40m1 stop
Turkish Airlines Logo
6:20 am - 7:50 pmMAD-PTY
19h 30m1 stop
$699Turkish Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 31
Air Europa Logo
8:25 pm - 1:15 pmPTY-MAD
9h 50mnonstop
Air Europa Logo
3:05 pm - 6:40 pmMAD-PTY
10h 35mnonstop
$704Air Europa
Find Deal
Sat, Sep 27 - Wed, Oct 15
KLM Logo
6:45 pm - 10:15 amPTY-MAD
33h 30m1 stop
KLM Logo
6:00 am - 4:30 pmMAD-PTY
16h 30m1 stop
$717KLM
Find Deal
Thu, Dec 25 - Wed, Mar 4
Avianca Logo
9:55 pm - 6:30 amPTY-MAD
26h 35m1 stop
Avianca Logo
10:55 am - 12:20 amMAD-PTY
19h 25m1 stop
$721Avianca
Find Deal
Thu, Oct 30 - Sat, Nov 8
KLM Logo
6:45 pm - 7:40 pmPTY-MAD
18h 55m1 stop
KLM Logo
6:00 am - 4:30 pmMAD-PTY
16h 30m1 stop
$724KLM
Find Deal
Thu, Dec 25 - Wed, Mar 4
Avianca Logo
3:25 am - 7:40 amPTY-MAD
21h 15m1 stop
Avianca Logo
12:35 am - 9:00 pmMAD-PTY
26h 25m1 stop
$744Avianca
Find Deal
Mon, Oct 20 - Wed, Nov 5
Air France Logo
7:55 pm - 7:20 pmPTY-MAD
16h 25m1 stop
Air France Logo
8:15 pm - 5:45 pmMAD-PTY
28h 30m1 stop
$758Air France
Find Deal
Tue, Sep 30 - Sat, Oct 11
Iberia Logo
6:20 pm - 10:25 amPTY-MAD
10h 05mnonstop
Iberia Logo
11:40 am - 4:45 pmMAD-PTY
11h 05mnonstop
$780Iberia
Find Deal
Sat, Nov 22 - Sat, Nov 29
Air France Logo
2:05 pm - 9:35 amPTY-MAD
36h 30m1 stop
Air France Logo
4:40 pm - 5:45 pmMAD-PTY
32h 05m1 stop
$784Air France
Find Deal
Wed, Sep 10 - Wed, Sep 24
Iberia Logo
6:20 pm - 10:25 amPTY-MAD
10h 05mnonstop
Iberia Logo
11:40 am - 4:45 pmMAD-PTY
11h 05mnonstop
$787Iberia
Find Deal
Mon, Nov 10 - Mon, Dec 1

Turkish Airlines flights from Panama City to Madrid

Our best Turkish Airlines deals on Panama City to Madrid flight tickets
Turkish Airlines
Jan 17
PTY9:45 pmPanama City Tocumen Intl
36h 40m
1 stop
MAD4:25 pmMadrid Barajas
Jan 31
MAD6:20 amMadrid Barajas
19h 30m
1 stop
PTY7:50 pmPanama City Tocumen Intl
$699
Find similar
Turkish Airlines
Oct 27
PTY9:45 pmPanama City Tocumen Intl
33h 35m
1 stop
MAD1:20 pmMadrid Barajas
Nov 11
MAD5:55 pmMadrid Barajas
31h 55m
1 stop
PTY7:50 pmPanama City Tocumen Intl
$720
Find similar
Turkish Airlines
Jan 17
PTY9:45 pmPanama City Tocumen Intl
36h 40m
1 stop
MAD4:25 pmMadrid Barajas
Feb 4
MAD2:25 pmMadrid Barajas
32h 40m
2 stops
PTY5:05 pmPanama City Tocumen Intl
$726
Find similar

Avianca flights from Panama City to Madrid

Our best Avianca deals on Panama City to Madrid flight tickets
Avianca
Oct 30
PTY9:55 pmPanama City Tocumen Intl
26h 35m
1 stop
MAD6:30 amMadrid Barajas
Nov 8
MAD10:55 amMadrid Barajas
19h 25m
1 stop
PTY12:20 amPanama City Tocumen Intl
$721
Find similar
Avianca
Oct 20
PTY3:25 amPanama City Tocumen Intl
21h 15m
1 stop
MAD7:40 amMadrid Barajas
Nov 5
MAD12:35 amMadrid Barajas
26h 25m
1 stop
PTY9:00 pmPanama City Tocumen Intl
$744
Find similar
Avianca
Nov 1
PTY5:55 pmPanama City Tocumen Intl
13h 30m
1 stop
MAD1:25 pmMadrid Barajas
Nov 6
MAD1:20 amMadrid Barajas
21h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$745
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 1/17

9:45 pm-4:25 pm

1 stop36h 40m

Madrid Barajas

Sat 1/31

6:20 am-7:50 pm

1 stop19h 30m

$699

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 9/27

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/15

3:05 pm-6:40 pm

Nonstop10h 35m

$704

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 12/25

6:45 pm-10:15 am

1 stop33h 30m

Madrid Barajas

Wed 3/4

6:00 am-4:30 pm

1 stop16h 30m

$717

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 10/30

9:55 pm-6:30 am

1 stop26h 35m

Madrid Barajas

Sat 11/8

10:55 am-12:20 am

1 stop19h 25m

$721

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 12/25

6:45 pm-7:40 pm

1 stop18h 55m

Madrid Barajas

Wed 3/4

6:00 am-4:30 pm

1 stop16h 30m

$724

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 10/20

3:25 am-7:40 am

1 stop21h 15m

Madrid Barajas

Wed 11/5

12:35 am-9:00 pm

1 stop26h 25m

$744

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/30

7:55 pm-7:20 pm

1 stop16h 25m

Madrid Barajas

Sat 10/11

8:15 pm-5:45 pm

1 stop28h 30m

$758

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 11/22

6:20 pm-10:25 am

Nonstop10h 05m

Madrid Barajas

Sat 11/29

11:40 am-4:45 pm

Nonstop11h 05m

$780

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 9/10

2:05 pm-9:35 am

1 stop36h 30m

Madrid Barajas

Wed 9/24

4:40 pm-5:45 pm

1 stop32h 05m

$784

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 11/10

6:20 pm-10:25 am

Nonstop10h 05m

Madrid Barajas

Mon 12/1

11:40 am-4:45 pm

Nonstop11h 05m

$787

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Madrid from

How to get the cheapest flight ticket from Panama City to Madrid

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Madrid?

The month of March is, on average, the cheapest month to fly to Madrid from Panama City, with most prices found around $689. If you don’t want to visit Madrid in March, then you should wait until February to fly from Panama City, when ticket prices are also cheap, with an average price of $696.

What is the cheapest day to depart on your flight to Madrid?

The cheapest day to depart on your flight to Madrid is on a Tuesday when prices can be found for as low as $812. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Madrid on Saturday is $870.

What is the cheapest time of day to depart on your flight to Madrid?

Flying to Madrid from Panama City in the morning is the least expensive time of day to depart. momondo users have found prices as low as $751 when looking at flights departing in the morning. Flights to Madrid are more costly at noon, with an average ticket price of $920. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Panama City Tocumen Intl to Madrid Barajas flight route?

Fly from Panama City Tocumen Intl to Madrid Barajas for the best Panama City Tocumen Intl - Madrid Barajas flight prices

How far in advance should I book a flight to Madrid?

You are more likely to see cheaper flights to Madrid from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Madrid for around $772 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Madrid from Panama City for as low as $719 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Madrid Barajas flights?

There are 3 cabin classes available to choose from on Panama City Tocumen Intl to Madrid Barajas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Madrid flights?

You could potentially save up to 14% on your flight if you consider stops on a Panama City to Madrid flight.

How have Panama City to Madrid flight prices changed over time?

As of July 2025, prices for Panama City to Madrid flights are approximately 19% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to Madrid

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Madrid according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Madrid (PTY to MAD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Madrid

Best Price Found

$403

Fastest flight time

9h 35m

Direct flights

Every day

Airports in Madrid

1 airport
The best one-way flight to Madrid from Panama City in the past 72 hours is $403. The best round-trip flight deal from Panama City to Madrid found on momondo in the last 72 hours is $699.
The fastest flight from Panama City to Madrid takes 9h 35m
Direct flights go from Panama City to Madrid every day.
There is 1 airport near Madrid: Madrid Barajas (MAD)
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  • How far is Panama City Tocumen Intl to Madrid Barajas by plane?

    The distance between Panama City Tocumen Intl and Madrid Barajas is about 5069.0 mi. Typically, this will take 9h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Madrid Barajas Airport.

  • What documentation or ID do you need to fly to Madrid Barajas Airport?

    The necessary travel and health documents for your Madrid Barajas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Madrid?

  • What is the most popular airline from Panama City to Madrid?

Best airlines flying from Panama City to Madrid

Compare and see reviews for airlines that fly from Panama City to Madrid with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $543Free CancellationRating
6.7
2,387 reviews
Search Avianca flights
Air EuropaPriceFrom $664Free CancellationRating
7.0
543 reviews
Search Air Europa flights
IberiaPriceFrom $678Free CancellationRating
7.0
2,859 reviews
Search Iberia flights
KLMPriceFrom $684Free CancellationRating
7.8
1,383 reviews
Search KLM flights
Air FrancePriceFrom $695Free CancellationRating
7.5
1,465 reviews
Search Air France flights
United AirlinesPriceFrom $700Free CancellationRating
7.4
8,896 reviews
Search United Airlines flights
Turkish AirlinesPriceFrom $719Free CancellationRating
7.3
3,928 reviews
Search Turkish Airlines flights

  • Air Europa Flights From Panama City to Madrid

    Across 7 Air Europa flights from Panama City to Madrid this week, the average price was $788, with the best Air Europa deals starting from $664 round-trip. 543 users have rated Air Europa on momondo, with an average score of 7.0/10.

  • Iberia Flights From Panama City to Madrid

    Another popular option for Panama City to Madrid flights is Iberia (7.0/10, 2,859 ratings). Iberia flies from Panama City to Madrid around 4 times per week, with deals starting from $678 round-trip and rising to an average price of around $827.

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Toledo
Segovia
Getafe
Fuenlabrada
San Lorenzo de El Escorial
Guadalajara

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Madrid?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Madrid. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Madrid with flexible booking policies on momondo?

Flights from Panama City to Madrid with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Madrid?

momondo helps you find the best flight between Panama City and Madrid by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Madrid right now. Can momondo alert me if prices change?

Price alerts on flights to Madrid from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Fly your favorite airline to Madrid

Airlines are sorted and displayed according to clicks in the past 7 days on momondo
American Airlines
Delta
United Airlines
Turkish Airlines
Lufthansa
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British Airways
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Ryanair
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