Cheap flights from Panama City to Madrid from $514

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Madrid departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Air France Logo
2:27 pm - 12:15 pm
PTY
-
MAD
14h 48m
1 stop
Air France Logo
8:15 pm - 7:45 pm
MAD
-
PTY
30h 30m
1 stop
$656Air France
Sun, Apr 19 - Fri, Apr 24
Iberia Logo
9:30 pm - 2:20 pm
PTY
-
MAD
9h 50mnonstop
Iberia Logo
3:55 pm - 8:00 pm
MAD
-
PTY
11h 05mnonstop
$661Iberia
Sun, May 10 - Fri, May 22
Air France Logo
2:27 pm - 12:15 pm
PTY
-
MAD
14h 48m
1 stop
Air France Logo
4:40 pm - 7:45 pm
MAD
-
PTY
34h 05m
1 stop
$665Air France
Wed, May 6 - Wed, May 27
Multiple Airlines Logo
2:28 pm - 12:15 pm
PTY
-
MAD
14h 47m
1 stop
Multiple Airlines Logo
6:00 am - 4:50 pm
MAD
-
PTY
17h 50m
1 stop
$671Multiple Airlines
Mon, Mar 30 - Wed, Apr 15
Iberia Logo
9:30 pm - 2:20 pm
PTY
-
MAD
9h 50mnonstop
Iberia Logo
3:55 pm - 8:00 pm
MAD
-
PTY
11h 05mnonstop
$672Iberia
Fri, May 1 - Sun, May 31
Multiple Airlines Logo
6:50 pm - 4:25 pm
PTY
-
MAD
14h 35m
1 stop
Multiple Airlines Logo
12:20 pm - 7:45 pm
MAD
-
PTY
14h 25m
1 stop
$674Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Avianca Logo
10:10 am - 11:10 am
PTY
-
MAD
18h 00m
1 stop
Avianca Logo
11:05 am - 12:45 am
MAD
-
PTY
20h 40m
1 stop
$682Avianca
Tue, May 19 - Fri, May 29
Air France Logo
2:28 pm - 12:15 pm
PTY
-
MAD
14h 47m
1 stop
Air France Logo
6:00 am - 7:45 pm
MAD
-
PTY
20h 45m
1 stop
$686Air France
Sun, Apr 5 - Mon, Apr 20
Multiple Airlines Logo
6:50 pm - 9:30 am
PTY
-
MAD
31h 40m
1 stop
Multiple Airlines Logo
10:05 am - 8:20 pm
MAD
-
PTY
17h 15m
2 stops
$687Multiple Airlines
Mon, Jun 1 - Wed, Jun 10
Turkish Airlines Logo
9:45 pm - 10:25 am
PTY
-
MAD
30h 40m
1 stop
Turkish Airlines Logo
6:20 am - 7:50 pm
MAD
-
PTY
19h 30m
1 stop
$691Turkish Airlines
Wed, Mar 11 - Sat, Mar 21

Iberia flights from Panama City to Madrid

Our best Iberia deals on Panama City to Madrid flight tickets
Iberia
May 10
PTY9:30 pmPanama City Tocumen Intl
9h 50m
MAD2:20 pmMadrid Barajas
May 22
MAD3:55 pmMadrid Barajas
11h 05m
PTY8:00 pmPanama City Tocumen Intl
$661
Iberia
May 1
PTY9:30 pmPanama City Tocumen Intl
9h 50m
MAD2:20 pmMadrid Barajas
May 31
MAD3:55 pmMadrid Barajas
11h 05m
PTY8:00 pmPanama City Tocumen Intl
$672

Air France flights from Panama City to Madrid

Our best Air France deals on Panama City to Madrid flight tickets
Air France
Apr 19
PTY2:27 pmPanama City Tocumen Intl
14h 48m
1 stop
MAD12:15 pmMadrid Barajas
Apr 24
MAD8:15 pmMadrid Barajas
30h 30m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$656
Air France
May 6
PTY2:27 pmPanama City Tocumen Intl
14h 48m
1 stop
MAD12:15 pmMadrid Barajas
May 27
MAD4:40 pmMadrid Barajas
34h 05m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$665
Air France
Apr 5
PTY2:28 pmPanama City Tocumen Intl
14h 47m
1 stop
MAD12:15 pmMadrid Barajas
Apr 20
MAD6:00 amMadrid Barajas
20h 45m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$686

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 4/19

2:27 pm-12:15 pm

1 stop14h 48m

Madrid Barajas

Fri 4/24

8:15 pm-7:45 pm

1 stop30h 30m

$656

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/10

9:30 pm-2:20 pm

Nonstop9h 50m

Madrid Barajas

Fri 5/22

3:55 pm-8:00 pm

Nonstop11h 05m

$661

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 5/6

2:27 pm-12:15 pm

1 stop14h 48m

Madrid Barajas

Wed 5/27

4:40 pm-7:45 pm

1 stop34h 05m

$665

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/30

2:28 pm-12:15 pm

1 stop14h 47m

Madrid Barajas

Wed 4/15

6:00 am-4:50 pm

1 stop17h 50m

$671

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 5/1

9:30 pm-2:20 pm

Nonstop9h 50m

Madrid Barajas

Sun 5/31

3:55 pm-8:00 pm

Nonstop11h 05m

$672

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 6/15

6:50 pm-4:25 pm

1 stop14h 35m

Madrid Barajas

Mon 6/22

12:20 pm-7:45 pm

1 stop14h 25m

$674

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 5/19

10:10 am-11:10 am

1 stop18h 00m

Madrid Barajas

Fri 5/29

11:05 am-12:45 am

1 stop20h 40m

$682

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 4/5

2:28 pm-12:15 pm

1 stop14h 47m

Madrid Barajas

Mon 4/20

6:00 am-7:45 pm

1 stop20h 45m

$686

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 6/1

6:50 pm-9:30 am

1 stop31h 40m

Madrid Barajas

Wed 6/10

10:05 am-8:20 pm

2 stops17h 15m

$687

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 3/11

9:45 pm-10:25 am

1 stop30h 40m

Madrid Barajas

Sat 3/21

6:20 am-7:50 pm

1 stop19h 30m

$691

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Madrid from

How to get the cheapest flight ticket from Panama City to Madrid

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Madrid?

What is the cheapest month to fly to Madrid?

The month of February is, on average, the cheapest month to fly to Madrid from Panama City, with most prices found around $714. If you don’t want to visit Madrid in February, then you should wait until May to fly from Panama City, when ticket prices are also cheap, with an average price of $714.

What is the cheapest day to depart on your flight to Madrid?

The cheapest day to depart on your flight to Madrid is on a Wednesday when prices can be found for as low as $856. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Madrid on Saturday is $917.

What is the cheapest time of day to depart on your flight to Madrid?

Flying to Madrid from Panama City in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $887 when looking at flights departing in the afternoon. Flights to Madrid are more costly in the evening, with an average ticket price of $889. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Panama City Tocumen Intl to Madrid Barajas flight route?

Fly from Panama City Tocumen Intl to Madrid Barajas for the best Panama City Tocumen Intl - Madrid Barajas flight prices

How far in advance should I book a flight to Madrid?

You are more likely to see cheaper flights to Madrid from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Madrid for around $786 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Madrid from Panama City for as low as $737 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Madrid Barajas flights?

There are 3 cabin classes available to choose from on Panama City Tocumen Intl to Madrid Barajas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Madrid flights?

You could potentially save up to 3% on your flight if you consider stops on a Panama City to Madrid flight.

How have Panama City to Madrid flight prices changed over time?

As of January 2026, prices for Panama City to Madrid flights are approximately 36% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Madrid

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Madrid according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Madrid (PTY to MAD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Madrid

Best Price Found

$768

Fastest flight time

9h 35m

Direct flights

Every day

Airports in Madrid

1 airport
The best one-way flight to Madrid from Panama City in the past 72 hours is $768. The best round-trip flight deal from Panama City to Madrid found on momondo in the last 72 hours is $756.
The fastest flight from Panama City to Madrid takes 9h 35m
Direct flights go from Panama City to Madrid every day.
There is 1 airport in Madrid. From Panama City there are direct flights to Madrid Barajas (MAD).
  • How far is Panama City Tocumen Intl to Madrid Barajas by plane?

    The distance between Panama City Tocumen Intl and Madrid Barajas is about 5069.0 mi. Typically, this will take 9h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Madrid Barajas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Madrid Barajas Airport.

  • What documentation or ID do you need to fly to Madrid Barajas Airport?

    The necessary travel and health documents for your Madrid Barajas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Madrid?

  • What is the most popular airline from Panama City to Madrid?

Best airlines flying from Panama City to Madrid

Compare and see reviews for airlines that fly from Panama City to Madrid with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $635Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
KLMPriceFrom $654Free CancellationRating
7.7
1,443 reviews
Search KLM flights
Air EuropaPriceFrom $671Free CancellationRating
6.9
587 reviews
Search Air Europa flights
IberiaPriceFrom $673Free CancellationRating
7.0
3,100 reviews
Search Iberia flights
Air FrancePriceFrom $695Free CancellationRating
7.4
1,528 reviews
Search Air France flights
Turkish AirlinesPriceFrom $698Free CancellationRating
7.3
4,208 reviews
Search Turkish Airlines flights
Copa AirlinesPriceFrom $722Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
  • Copa Airlines Flights From Panama City to Madrid

    Across 9 Copa Airlines flights from Panama City to Madrid this week, the average price was $1,269, with the best Copa Airlines deals starting from $722 round-trip. 1,560 users have rated Copa Airlines on momondo, with an average score of 7.5/10.

  • Iberia Flights From Panama City to Madrid

    Another popular option for Panama City to Madrid flights is Iberia (7.0/10, 3,100 ratings). Iberia flies from Panama City to Madrid around 3 times per week, with deals starting from $673 round-trip and rising to an average price of around $839.

Traveling to a place near Madrid?

Book flights to Madrid if you plan to visit one of these locations
Toledo
Segovia
Fuenlabrada
Getafe
Cuenca
San Lorenzo de El Escorial
Guadalajara

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Madrid?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Madrid. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Madrid with flexible booking policies on momondo?

Flights from Panama City to Madrid with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Madrid?

momondo helps you find the best flight between Panama City and Madrid by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Madrid right now. Can momondo alert me if prices change?

Price alerts on flights to Madrid from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Madrid trip

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1 adult
Sat 2/28
Sat 3/7

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Airlines are sorted and displayed according to clicks in the past 7 days on momondo