Cheap flights from Chicago O'Hare Intl Airport to Brussels from $345

In general, April is the cheapest month to fly from Chicago O'Hare Intl Airport to Brussels. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $646. If you are unable to visit Brussels during the month of April, then departing from Chicago O'Hare Intl Airport during the month October is also very affordable. Most momondo users find prices during this month for around $673.

On average, the least expensive day to fly to Brussels from Chicago O'Hare Intl Airport is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $1,147. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Saturday is the most expensive day to depart from Chicago O'Hare Intl Airport because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $1,438.

According to our data, the cheapest time of day to fly to Brussels is in the evening. momondo users have found flights departing from Chicago O'Hare Intl Airport to Brussels in the evening for as low as $1,234. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the afternoon are often more expensive with an average ticket price of $1,345.

Fly from Chicago O'Hare Intl to Brussels Bruxelles-National for the best Chicago O'Hare Intl - Brussels flight prices

You are more likely to see cheaper flights to Brussels from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels for around $911 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels from Chicago O'Hare Intl Airport for as low as $591 on momondo.

There are 3 cabin classes available to choose from on Chicago O'Hare Intl Airport to Brussels flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Scandinavian Airlines, Turkish Airlines, and Aer Lingus are the most popular carriers operating from Chicago O'Hare Intl to Brussels

Scandinavian Airlines, United Airlines and Icelandair are the top three most popular airlines that fly to Brussels from Chicago O'Hare Intl Airport according to our data. Scandinavian Airlines is the first choice among our users, with 37% of people opting to fly with this airline when traveling to Brussels. Keep in mind that there are 7 different airlines that fly to Brussels on a routine basis, so you have a few additional options to choose from.

5 flights are operational daily from Chicago O'Hare Intl Airport to Brussels as of November 2026. The most popular departure time for this route is 7:00PM, with 100% of flights per day taking off in the evening.

As of November 2026, there are 35 flights per week flying from Chicago O'Hare Intl Airport to Brussels. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.