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Cheap flights from North Carolina to Santiago from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Santiago departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from North Carolina to Santiago

Cheap round-trip flights

Copa Airlines Logo
4:19 pm - 6:00 amRDU-SCL
12h 41m1 stop
Copa Airlines Logo
1:13 am - 2:27 pmSCL-RDU
14h 14m1 stop
$550Copa Airlines
Find Deal
Wed, Oct 1 - Tue, Oct 7
American Airlines Logo
6:30 pm - 7:55 amRDU-SCL
12h 25m1 stop
American Airlines Logo
9:55 pm - 5:39 pmSCL-RDU
20h 44m1 stop
$560American Airlines
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Thu, Oct 2 - Thu, Oct 9
Logo
7:25 pm - 3:35 amRDU-SCL
31h 10m2 stops
Logo
11:00 am - 6:34 pmSCL-RDU
32h 34m1 stop
$592
Find Deal
Mon, Sep 15 - Sun, Sep 28
Logo
7:25 pm - 3:35 amRDU-SCL
31h 10m2 stops
Logo
11:00 am - 6:34 pmSCL-RDU
32h 34m1 stop
$600
Find Deal
Mon, Sep 15 - Thu, Sep 25
LATAM Airlines Logo
3:08 pm - 7:00 amRDU-SCL
14h 52m1 stop
LATAM Airlines Logo
12:25 am - 4:06 pmSCL-RDU
16h 41m2 stops
$677LATAM Airlines
Find Deal
Sun, Sep 14 - Fri, Sep 26
LATAM Airlines Logo
12:19 pm - 6:45 amRDU-SCL
17h 26m2 stops
LATAM Airlines Logo
12:25 am - 6:54 pmSCL-RDU
19h 29m2 stops
$681LATAM Airlines
Find Deal
Thu, Oct 2 - Wed, Oct 8
Delta Logo
2:25 pm - 7:50 amRDU-SCL
16h 25m1 stop
Delta Logo
9:40 pm - 9:38 amSCL-RDU
12h 58m1 stop
$684Delta
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Fri, Sep 12 - Mon, Sep 29
United Airlines Logo
10:20 am - 8:50 amGSO-SCL
20h 30m2 stops
United Airlines Logo
10:45 pm - 2:14 pmSCL-GSO
17h 29m2 stops
$738United Airlines
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Thu, Dec 4 - Mon, Dec 8
United Airlines Logo
6:30 am - 8:50 amGSO-SCL
24h 20m2 stops
United Airlines Logo
10:45 pm - 8:45 pmSCL-GSO
24h 00m2 stops
$778United Airlines
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Wed, Nov 5 - Fri, Nov 14
Delta Logo
12:49 pm - 6:40 amTRI-SCL
15h 51m2 stops
Delta Logo
8:50 am - 10:24 pmSCL-TRI
15h 34m2 stops
$814Delta
Find Deal
Fri, Dec 5 - Tue, Dec 9

Delta flights from North Carolina to Santiago

Our best Delta deals on North Carolina to Santiago flight tickets
Delta
Sep 12
RDU2:25 pmRaleigh-Durham
16h 25m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Sep 29
SCL9:40 pmSantiago Arturo Merino Benitez
12h 58m
1 stop
RDU9:38 amRaleigh-Durham
$684
Find similar
Delta
Dec 5
TRI12:49 pmBlountville Tri Cities TN/VA
15h 51m
2 stops
SCL6:40 amSantiago Arturo Merino Benitez
Dec 9
SCL8:50 amSantiago Arturo Merino Benitez
15h 34m
2 stops
TRI10:24 pmBlountville Tri Cities TN/VA
$814
Find similar
Delta
Oct 11
FAY11:09 amFayetteville
18h 41m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
Oct 14
SCL1:40 amSantiago Arturo Merino Benitez
22h 27m
2 stops
FAY11:07 pmFayetteville
$818
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LATAM Airlines flights from North Carolina to Santiago

Our best LATAM Airlines deals on North Carolina to Santiago flight tickets
LATAM Airlines
Sep 14
RDU3:08 pmRaleigh-Durham
14h 52m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Sep 26
SCL12:25 amSantiago Arturo Merino Benitez
16h 41m
2 stops
RDU4:06 pmRaleigh-Durham
$677
Find similar
LATAM Airlines
Oct 2
RDU12:19 pmRaleigh-Durham
17h 26m
2 stops
SCL6:45 amSantiago Arturo Merino Benitez
Oct 8
SCL12:25 amSantiago Arturo Merino Benitez
19h 29m
2 stops
RDU6:54 pmRaleigh-Durham
$681
Find similar
LATAM Airlines
Aug 24
RDU12:20 pmRaleigh-Durham
17h 25m
2 stops
SCL5:45 amSantiago Arturo Merino Benitez
Aug 30
SCL11:25 pmSantiago Arturo Merino Benitez
16h 47m
2 stops
RDU4:12 pmRaleigh-Durham
$684
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momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from North Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Wed 10/1

4:19 pm-6:00 am

1 stop12h 41m

Santiago Arturo Merino Benitez

Tue 10/7

1:13 am-2:27 pm

1 stop14h 14m

$550

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Thu 10/2

6:30 pm-7:55 am

1 stop12h 25m

Santiago Arturo Merino Benitez

Thu 10/9

9:55 pm-5:39 pm

1 stop20h 44m

$560

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Mon 9/15

7:25 pm-3:35 am

2 stops31h 10m

Santiago Arturo Merino Benitez

Sun 9/28

11:00 am-6:34 pm

1 stop32h 34m

$592

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Mon 9/15

7:25 pm-3:35 am

2 stops31h 10m

Santiago Arturo Merino Benitez

Thu 9/25

11:00 am-6:34 pm

1 stop32h 34m

$600

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Sun 9/14

3:08 pm-7:00 am

1 stop14h 52m

Santiago Arturo Merino Benitez

Fri 9/26

12:25 am-4:06 pm

2 stops16h 41m

$677

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Thu 10/2

12:19 pm-6:45 am

2 stops17h 26m

Santiago Arturo Merino Benitez

Wed 10/8

12:25 am-6:54 pm

2 stops19h 29m

$681

RaleighSantiago

RDU - SCL

RDUSCL

Raleigh-Durham

Fri 9/12

2:25 pm-7:50 am

1 stop16h 25m

Santiago Arturo Merino Benitez

Mon 9/29

9:40 pm-9:38 am

1 stop12h 58m

$684

GreensboroSantiago

GSO - SCL

GSOSCL

Greensboro/H. Point

Thu 12/4

10:20 am-8:50 am

2 stops20h 30m

Santiago Arturo Merino Benitez

Mon 12/8

10:45 pm-2:14 pm

2 stops17h 29m

$738

GreensboroSantiago

GSO - SCL

GSOSCL

Greensboro/H. Point

Wed 11/5

6:30 am-8:50 am

2 stops24h 20m

Santiago Arturo Merino Benitez

Fri 11/14

10:45 pm-8:45 pm

2 stops24h 00m

$778

BlountvilleSantiago

TRI - SCL

TRISCL

Blountville Tri Cities TN/VA

Fri 12/5

12:49 pm-6:40 am

2 stops15h 51m

Santiago Arturo Merino Benitez

Tue 12/9

8:50 am-10:24 pm

2 stops15h 34m

$814

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from North Carolina to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from North Carolina to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $823. If you don’t want to visit Santiago in September, then you should wait until February to fly from North Carolina, when ticket prices are also cheap, with an average price of $857.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $841. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,002.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from North Carolina to Santiago when you can find flight prices for as low as $895. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,147 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $946 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from North Carolina for as low as $826 on momondo.

Cheap North Carolina to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Santiago

Best Price Found

$278

Fastest flight time

11h 15m

Direct flights

None

Airports in Santiago

1 airport
The best one-way flight to Santiago from North Carolina in the past 72 hours is $278. The best round-trip flight deal from North Carolina to Santiago found on momondo in the last 72 hours is $550.
The fastest flight from North Carolina to Santiago takes 11h 15m
There are no direct flights from North Carolina to Santiago. Popular non-direct routes for this connection are Charlotte Douglas Airport - Santiago Arturo Merino Benitez Airport, Raleigh-Durham Airport - Santiago Arturo Merino Benitez Airport and Asheville Regional Airport - Santiago Arturo Merino Benitez Airport.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • When did momondo last update prices for flights from North Carolina to Santiago Arturo Merino Benitez Airport?

    Prices for flights from North Carolina to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from North Carolina to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from North Carolina to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from North Carolina to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents you'll need for your trip to Santiago Arturo Merino Benitez Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from North Carolina to Santiago

Compare and see reviews for airlines that fly from North Carolina to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $418Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights
DeltaPriceFrom $608Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $683Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $683Free CancellationRating
7.5
1,844 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Santiago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from North Carolina to Santiago for you.

Can I find flights from North Carolina to Santiago with flexible booking policies on momondo?

All flight searches from North Carolina to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from North Carolina to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from North Carolina. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from North Carolina to Santiago right now. Can momondo alert me if prices change?

Price alerts on flights to Santiago from North Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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