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Cheap flights from Missouri to Chicago from $48

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Chicago departing on 11/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Contour Logo
9:55 am - 11:40 amUIN  Quincy Regional-ORD Chicago O'Hare Intl
1h 45mnonstop
Contour Logo
12:30 pm - 1:55 pmORD  Chicago O'Hare Intl-UIN Quincy Regional
1h 25mnonstop
$92Contour
Wed, Nov 25 - Sun, Nov 29
Contour Logo
3:25 pm - 5:10 pmUIN  Quincy Regional-ORD Chicago O'Hare Intl
1h 45mnonstop
Contour Logo
12:30 pm - 1:55 pmORD  Chicago O'Hare Intl-UIN Quincy Regional
1h 25mnonstop
$95Contour
Tue, Sep 15 - Sat, Oct 3
United Airlines Logo
6:54 pm - 8:30 pmSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
1h 36mnonstop
United Airlines Logo
8:29 pm - 10:00 pmORD  Chicago O'Hare Intl-STL Lambert-St Louis
1h 31mnonstop
$117United Airlines
Sat, Sep 5 - Mon, Sep 7
United Airlines Logo
7:25 am - 9:01 amSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
1h 36mnonstop
United Airlines Logo
10:29 am - 12:02 pmORD  Chicago O'Hare Intl-STL Lambert-St Louis
1h 33mnonstop
$117United Airlines
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
11:01 am - 12:29 pmSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
1h 28mnonstop
American Airlines Logo
11:48 am - 1:16 pmORD  Chicago O'Hare Intl-STL Lambert-St Louis
1h 28mnonstop
$117American Airlines
Wed, Sep 9 - Thu, Sep 10
American Airlines Logo
11:01 am - 12:29 pmSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
1h 28mnonstop
American Airlines Logo
11:00 pm - 12:19 amORD  Chicago O'Hare Intl-STL Lambert-St Louis
1h 19mnonstop
$117American Airlines
Mon, Sep 28 - Mon, Oct 5
Frontier Logo
5:53 pm - 12:26 amSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
6h 33m1 stop Dallas/Fort Worth
Frontier Logo
10:26 am - 5:40 pmORD  Chicago O'Hare Intl-STL Lambert-St Louis
7h 14m1 stop Atlanta Hartsfield-Jackson
$118Frontier
Thu, Oct 15 - Mon, Oct 19
Frontier Logo
10:20 am - 7:35 pmSTL  Lambert-St Louis-ORD Chicago O'Hare Intl
9h 15m1 stop Dallas/Fort Worth
Frontier Logo
6:30 am - 7:17 pmORD  Chicago O'Hare Intl-STL Lambert-St Louis
12h 47m1 stop Denver Intl
$118Frontier
Thu, Oct 1 - Sat, Oct 3
Multiple Airlines Logo
2:40 pm - 10:59 pmUIN  Quincy Regional-ORD Chicago O'Hare Intl
32h 19m2 stops Nashville Intl Orlando
Multiple Airlines Logo
12:30 pm - 1:55 pmORD  Chicago O'Hare Intl-UIN Quincy Regional
1h 25mnonstop
$239Multiple Airlines
Mon, Sep 28 - Mon, Oct 5
Multiple Airlines Logo
9:55 am - 11:40 amUIN  Quincy Regional-ORD Chicago O'Hare Intl
1h 45mnonstop
Multiple Airlines Logo
6:30 am - 9:25 amORD  Chicago O'Hare Intl-UIN Quincy Regional
26h 55m2 stops Denver Intl Nashville Intl
$245Multiple Airlines
Thu, Sep 10 - Wed, Sep 16

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Contour flights from Missouri to Chicago O'Hare Intl Airport

Our best Contour deals on Missouri to Chicago O'Hare Intl Airport flight tickets
Contour
Nov 25
UIN9:55 amQuincy Regional
1h 45m
ORD11:40 amChicago O'Hare Intl
Nov 29
ORD12:30 pmChicago O'Hare Intl
1h 25m
UIN1:55 pmQuincy Regional
$92
Contour
Sep 9
UIN9:55 amQuincy Regional
1h 45m
ORD11:40 amChicago O'Hare Intl
Sep 16
ORD12:30 pmChicago O'Hare Intl
1h 25m
UIN1:55 pmQuincy Regional
$95
Contour
Aug 27
UIN9:55 amQuincy Regional
1h 45m
ORD11:40 amChicago O'Hare Intl
Aug 31
ORD12:30 pmChicago O'Hare Intl
1h 25m
UIN1:55 pmQuincy Regional
$96

American Airlines flights from Missouri to Chicago O'Hare Intl Airport

Our best American Airlines deals on Missouri to Chicago O'Hare Intl Airport flight tickets
American Airlines
Sep 5
STL5:13 pmLambert-St Louis
1h 39m
ORD6:52 pmChicago O'Hare Intl
Sep 6
ORD11:29 amChicago O'Hare Intl
1h 25m
STL12:54 pmLambert-St Louis
$118
American Airlines
Sep 4
STL8:07 pmLambert-St Louis
1h 33m
ORD9:40 pmChicago O'Hare Intl
Sep 5
ORD7:00 amChicago O'Hare Intl
1h 24m
STL8:24 amLambert-St Louis
$134
American Airlines
Sep 7
STL8:07 pmLambert-St Louis
1h 33m
ORD9:40 pmChicago O'Hare Intl
Sep 11
ORD8:55 amChicago O'Hare Intl
1h 23m
STL10:18 amLambert-St Louis
$135

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Missouri to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

QuincyChicago

UIN Quincy Regional - ORD Chicago O'Hare Intl

UINORD

Quincy Regional

Wed 11/25

9:55 am-11:40 am

Nonstop1h 45m

Chicago O'Hare Intl

Sun 11/29

12:30 pm-1:55 pm

Nonstop1h 25m

$92

QuincyChicago

UIN Quincy Regional - ORD Chicago O'Hare Intl

UINORD

Quincy Regional

Tue 9/15

3:25 pm-5:10 pm

Nonstop1h 45m

Chicago O'Hare Intl

Sat 10/3

12:30 pm-1:55 pm

Nonstop1h 25m

$95

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Sat 9/5

6:54 pm-8:30 pm

Nonstop1h 36m

Chicago O'Hare Intl

Mon 9/7

8:29 pm-10:00 pm

Nonstop1h 31m

$117

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Sat 9/5

7:25 am-9:01 am

Nonstop1h 36m

Chicago O'Hare Intl

Sun 9/6

10:29 am-12:02 pm

Nonstop1h 33m

$117

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Wed 9/9

11:01 am-12:29 pm

Nonstop1h 28m

Chicago O'Hare Intl

Thu 9/10

11:48 am-1:16 pm

Nonstop1h 28m

$117
Quickest round-trip

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Mon 9/28

11:01 am-12:29 pm

Nonstop1h 28m

Chicago O'Hare Intl

Mon 10/5

11:00 pm-12:19 am

Nonstop1h 19m

$117

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Thu 10/15

5:53 pm-12:26 am

1 stop6h 33m

Chicago O'Hare Intl

Mon 10/19

10:26 am-5:40 pm

1 stop7h 14m

$118

St. LouisChicago

STL Lambert-St Louis - ORD Chicago O'Hare Intl

STLORD

Lambert-St Louis

Thu 10/1

10:20 am-7:35 pm

1 stop9h 15m

Chicago O'Hare Intl

Sat 10/3

6:30 am-7:17 pm

1 stop12h 47m

$118

QuincyChicago

UIN Quincy Regional - ORD Chicago O'Hare Intl

UINORD

Quincy Regional

Mon 9/28

2:40 pm-10:59 pm

2 stops32h 19m

Chicago O'Hare Intl

Mon 10/5

12:30 pm-1:55 pm

Nonstop1h 25m

$239

QuincyChicago

UIN Quincy Regional - ORD Chicago O'Hare Intl

UINORD

Quincy Regional

Thu 9/10

9:55 am-11:40 am

Nonstop1h 45m

Chicago O'Hare Intl

Wed 9/16

6:30 am-9:25 am

2 stops26h 55m

$245

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Missouri to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of October is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Missouri averaging around $295.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $701. This is often the case because there is less demand to fly during this day of the week. On the other hand, Wednesday is the most expensive day to depart from Missouri because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $884.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Missouri in the morning is the least expensive time of day to depart. momondo users have found prices as low as $627 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $1,159. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Chicago O'Hare Intl flight route?

Fly from Kirksville Cannon Memorial to Chicago O'Hare Intl for the best Missouri - Chicago O'Hare Intl flight prices

How far in advance should I book a flight from Missouri to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $349 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Missouri for as low as $97 on momondo.

What cabin class options are available on Missouri to Chicago O'Hare Intl Airport flights?

There are 4 cabin classes available to choose from on Missouri to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Chicago O'Hare Intl Airport flights?

No. A direct flight is the cheapest option for a flight between Missouri to Chicago O'Hare Intl Airport.

Cheap Missouri to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Chicago O'Hare Intl Airport

Best Price Found

$117

Fastest flight time

1h 27m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Missouri in the past 72 hours is $117. The best round-trip flight deal from Missouri to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $138.
The fastest flight from Missouri to Chicago O'Hare Intl Airport takes 1h 27m
Direct flights go from Missouri to Chicago O'Hare Intl Airport every day.
Search flight deals

Frequently asked questions about flying from Missouri to Chicago O'Hare Intl Airport

  • When did momondo last update prices for flights from Missouri to Chicago O'Hare Intl Airport?

    Prices for flights from Missouri to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Missouri to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The travel and health documents required for your trip to Chicago O'Hare Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Chicago O'Hare Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to Chicago O'Hare Intl Airport?

Best airlines flying from Missouri to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Missouri to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
ContourPriceFrom $62Free CancellationRating
7.5
43 reviews
Search Contour flights
American AirlinesPriceFrom $97Free CancellationRating
7.1
11,947 reviews
Search American Airlines flights
United AirlinesPriceFrom $117Free CancellationRating
7.4
10,104 reviews
Search United Airlines flights
FrontierPriceFrom $158Free CancellationRating
5.6
2,684 reviews
Search Frontier flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
Merrillville
Rockford
South Haven
Gurnee
Rosemont
Oak Brook
Orland Park
Naperville
Joliet
New Buffalo
Kenosha
Hammond
Racine
Aurora
Janesville
Elgin
South Holland
Evanston

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Chicago?

It is quick and easy to find Missouri to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Missouri to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Missouri on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Missouri to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Missouri. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Missouri to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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