Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Chicago from $66

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Chicago departing on 2/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Contour Logo
5:30 pm - 6:50 pm
UIN
-
ORD
1h 20mnonstop
Contour Logo
7:30 pm - 8:50 pm
ORD
-
UIN
1h 20mnonstop
$89Contour
Mon, Jan 5 - Fri, Jan 9
Contour Logo
5:30 pm - 6:50 pm
UIN
-
ORD
1h 20mnonstop
Contour Logo
7:30 pm - 8:50 pm
ORD
-
UIN
1h 20mnonstop
$98Contour
Wed, Feb 18 - Thu, Feb 19
Multiple Airlines Logo
5:11 pm - 1:13 pm
STL
-
ORD
20h 02m1 stop
Multiple Airlines Logo
10:48 am - 10:34 pm
ORD
-
STL
11h 46m1 stop
$141Multiple Airlines
Mon, Jan 12 - Wed, Jan 14
Multiple Airlines Logo
8:32 pm - 12:08 pm
STL
-
ORD
15h 36m1 stop
Multiple Airlines Logo
10:48 am - 11:33 pm
ORD
-
STL
12h 45m1 stop
$143Multiple Airlines
Wed, Jan 14 - Wed, Jan 21
United Airlines Logo
6:40 pm - 8:23 pm
STL
-
ORD
1h 43mnonstop
United Airlines Logo
1:00 pm - 2:30 pm
ORD
-
STL
1h 30mnonstop
$153United Airlines
Wed, Feb 4 - Wed, Feb 11
American Airlines Logo
6:00 am - 7:27 am
STL
-
ORD
1h 27mnonstop
American Airlines Logo
1:25 pm - 2:50 pm
ORD
-
STL
1h 25mnonstop
$154American Airlines
Tue, Jan 20 - Tue, Jan 20
American Airlines Logo
6:00 am - 7:27 am
STL
-
ORD
1h 27mnonstop
American Airlines Logo
8:50 am - 10:20 am
ORD
-
STL
1h 30mnonstop
$162American Airlines
Wed, Jan 21 - Thu, Jan 22
United Airlines Logo
3:14 pm - 5:05 pm
SGF
-
ORD
1h 51mnonstop
United Airlines Logo
12:45 pm - 2:38 pm
ORD
-
SGF
1h 53mnonstop
$189United Airlines
Tue, Jan 20 - Tue, Jan 27
Delta Logo
6:00 am - 1:40 pm
SGF
-
ORD
7h 40m1 stop
Delta Logo
5:30 am - 11:20 am
ORD
-
SGF
5h 50m1 stop
$209Delta
Thu, Jan 22 - Sun, Jan 25
Delta Logo
6:00 am - 4:38 pm
SGF
-
ORD
10h 38m2 stops
Delta Logo
5:30 am - 11:20 am
ORD
-
SGF
5h 50m1 stop
$214Delta
Thu, Jan 22 - Sun, Jan 25

United Airlines flights from Missouri to Chicago O'Hare Intl Airport

Our best United Airlines deals on Missouri to Chicago O'Hare Intl Airport flight tickets
United Airlines
Feb 4
STL6:40 pmLambert-St Louis
1h 43m
ORD8:23 pmChicago O'Hare Intl
Feb 11
ORD1:00 pmChicago O'Hare Intl
1h 30m
STL2:30 pmLambert-St Louis
$153
Find similar
United Airlines
Jan 22
STL11:20 amLambert-St Louis
1h 35m
ORD12:55 pmChicago O'Hare Intl
Jan 24
ORD10:52 amChicago O'Hare Intl
1h 37m
STL12:29 pmLambert-St Louis
$171
Find similar
United Airlines
Jan 15
SGF3:14 pmSpringfield-Branson
1h 51m
ORD5:05 pmChicago O'Hare Intl
Jan 18
ORD12:45 pmChicago O'Hare Intl
1h 53m
SGF2:38 pmSpringfield-Branson
$190
Find similar

Delta flights from Missouri to Chicago O'Hare Intl Airport

Our best Delta deals on Missouri to Chicago O'Hare Intl Airport flight tickets
Delta
Feb 4
STL3:31 pmLambert-St Louis
5h 59m
1 stop
ORD9:30 pmChicago O'Hare Intl
Feb 11
ORD6:45 pmChicago O'Hare Intl
4h 40m
1 stop
STL11:25 pmLambert-St Louis
$173
Find similar
Delta
Jan 21
STL11:23 amLambert-St Louis
6h 32m
1 stop
ORD5:55 pmChicago O'Hare Intl
Jan 22
ORD6:15 amChicago O'Hare Intl
4h 28m
1 stop
STL10:43 amLambert-St Louis
$182
Find similar
Delta
Jan 14
STL6:10 amLambert-St Louis
6h 58m
2 stops
ORD1:08 pmChicago O'Hare Intl
Jan 21
ORD6:50 amChicago O'Hare Intl
9h 55m
2 stops
STL4:45 pmLambert-St Louis
$183
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Missouri to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuincyChicago

UIN - ORD

UINORD

Quincy Regional

Mon 1/5

5:30 pm-6:50 pm

Nonstop1h 20m

Chicago O'Hare Intl

Fri 1/9

7:30 pm-8:50 pm

Nonstop1h 20m

$89

QuincyChicago

UIN - ORD

UINORD

Quincy Regional

Wed 2/18

5:30 pm-6:50 pm

Nonstop1h 20m

Chicago O'Hare Intl

Thu 2/19

7:30 pm-8:50 pm

Nonstop1h 20m

$98

St. LouisChicago

STL - ORD

STLORD

Lambert-St Louis

Mon 1/12

5:11 pm-1:13 pm

1 stop20h 02m

Chicago O'Hare Intl

Wed 1/14

10:48 am-10:34 pm

1 stop11h 46m

$141

St. LouisChicago

STL - ORD

STLORD

Lambert-St Louis

Wed 1/14

8:32 pm-12:08 pm

1 stop15h 36m

Chicago O'Hare Intl

Wed 1/21

10:48 am-11:33 pm

1 stop12h 45m

$143

St. LouisChicago

STL - ORD

STLORD

Lambert-St Louis

Wed 2/4

6:40 pm-8:23 pm

Nonstop1h 43m

Chicago O'Hare Intl

Wed 2/11

1:00 pm-2:30 pm

Nonstop1h 30m

$153

St. LouisChicago

STL - ORD

STLORD

Lambert-St Louis

Tue 1/20

6:00 am-7:27 am

Nonstop1h 27m

Chicago O'Hare Intl

Tue 1/20

1:25 pm-2:50 pm

Nonstop1h 25m

$154

St. LouisChicago

STL - ORD

STLORD

Lambert-St Louis

Wed 1/21

6:00 am-7:27 am

Nonstop1h 27m

Chicago O'Hare Intl

Thu 1/22

8:50 am-10:20 am

Nonstop1h 30m

$162

SpringfieldChicago

SGF - ORD

SGFORD

Springfield-Branson

Tue 1/20

3:14 pm-5:05 pm

Nonstop1h 51m

Chicago O'Hare Intl

Tue 1/27

12:45 pm-2:38 pm

Nonstop1h 53m

$189

SpringfieldChicago

SGF - ORD

SGFORD

Springfield-Branson

Thu 1/22

6:00 am-1:40 pm

1 stop7h 40m

Chicago O'Hare Intl

Sun 1/25

5:30 am-11:20 am

1 stop5h 50m

$209

SpringfieldChicago

SGF - ORD

SGFORD

Springfield-Branson

Thu 1/22

6:00 am-4:38 pm

2 stops10h 38m

Chicago O'Hare Intl

Sun 1/25

5:30 am-11:20 am

1 stop5h 50m

$214

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Chicago from

How to get the cheapest flight ticket from Missouri to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of April is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Missouri averaging around $228.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Thursday when prices can be found for as low as $772. This is often the case because there is less demand to fly during this day of the week. On the other hand, Wednesday is the most expensive day to depart from Missouri because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $949.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Missouri in the morning is the least expensive time of day to depart. momondo users have found prices as low as $650 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $1,228. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Chicago O'Hare Intl flight route?

Fly from Cape Girardeau to Chicago O'Hare Intl for the best Missouri - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $277 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Missouri for as low as $178 on momondo.

What cabin class options are available on Missouri to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on Missouri to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Chicago O'Hare Intl Airport flights?

No. A direct flight is the cheapest option for a flight between Missouri to Chicago O'Hare Intl Airport.

Cheap Missouri to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Chicago O'Hare Intl Airport

Best Price Found

$64

Fastest flight time

1h 20m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Missouri in the past 72 hours is $64. The best round-trip flight deal from Missouri to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $191.
The fastest flight from Missouri to Chicago O'Hare Intl Airport takes 1h 20m
Direct flights go from Missouri to Chicago O'Hare Intl Airport every day.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Chicago O'Hare Intl Airport?

    Prices for flights from Missouri to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Missouri to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The travel and health documents required for your trip to Chicago O'Hare Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Chicago O'Hare Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to Chicago O'Hare Intl Airport?

Best airlines flying from Missouri to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Missouri to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $106Free CancellationRating
7.2
11,053 reviews
Search American Airlines flights
United AirlinesPriceFrom $114Free CancellationRating
7.4
9,103 reviews
Search United Airlines flights
ContourPriceFrom $123Free CancellationRating
7.6
43 reviews
Search Contour flights
Southern / MokulelePriceFrom $140Free CancellationRating
0.0
0 reviews
Search Southern / Mokulele flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
South Haven
Rockford
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Orland Park
Racine
Hammond
Janesville
Tinley Park
Aurora
Elgin
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Chicago?

It is quick and easy to find Missouri to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Missouri to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Missouri on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Missouri to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Missouri. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Missouri to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Chicago O'Hare Intl Airport trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 1/22
Thu 1/29
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Chicago