Cheap flights from Massachusetts to Panama from $324

The month of May is, on average, the cheapest month to fly to Panama from Massachusetts, with most prices found around $610. If you don’t want to visit Panama in May, then you should wait until March to fly from Massachusetts, when ticket prices are also cheap, with an average price of $657.

According to our data, Monday is the cheapest day to fly to Panama from Massachusetts. The lowest ticket price found for a Monday departure recently was $607. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Massachusetts to Panama for around $733.

In the afternoon is the cheapest time of day to fly from Massachusetts to Panama when you can find flight prices for as low as $551. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Panama, so prices are often more expensive at around $760 per ticket.

Fly from Boston Logan Intl to Panama City Tocumen Intl for the best Massachusetts - Panama flight prices

You are more likely to see cheaper flights to Panama from Massachusetts when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $722 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Massachusetts for as low as $593 on momondo.

There are 3 cabin classes available to choose from on Massachusetts to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines and Copa Airlines are the most popular carriers operating from Massachusetts to Panama

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama from Massachusetts according to our data. Copa Airlines is the first choice among our users, with 89% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 5 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

The number of flights available between Massachusetts and Panama is 2 per day as of November 2026. The most frequent departure time is 8:00AM, with 100% of daily flights leaving at noon.

The number of flights available between Massachusetts and Panama is 15 per week as of November 2026. The most frequent departure day is Mon, with 20% of weekly flights leaving on this day.