Cheap flights from Madrid to Santiago from $406

In general, May is the cheapest month to fly from Madrid to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $913. If you don’t want to visit Santiago in May, then you should wait until March to fly from Madrid, when ticket prices are also cheap, with an average price of $938.

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $1,261. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Friday is $1,700.

In the morning is the cheapest time of day to fly from Madrid to Santiago when you can find flight prices for as low as $1,240. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,522 per ticket.

Fly from Madrid Barajas to Santiago Arturo Merino Benitez for the best Madrid Barajas - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $1,108 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Madrid for as low as $992 on momondo.

There are 3 cabin classes available to choose from on Madrid to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 15% on your flight if you consider stops on a Madrid to Santiago flight.

As of July 2026, prices for Madrid to Santiago flights are approximately 15% more expensive when compared to flights at the same time last year.

Historically, on average around 19% of flights between Madrid and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 119 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 16% of their flights experiencing any sort of delay.

As of July 2026, 13 flights take off from Madrid and land in Santiago each day. The most common flight departure time for this route is 11:00PM, with 66% of daily flights taking off in the evening.

As of July 2026, there are 93 flights per week flying from Madrid to Santiago. The most common day of the week flights depart is Wed, with 18% of flights taking off on this day.