Cheap flights from Madrid to Santiago from $432

In general, March is the cheapest month to fly from Madrid to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $941. If you don’t want to visit Santiago in March, then you should wait until May to fly from Madrid, when ticket prices are also cheap, with an average price of $957.

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $1,342. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,632.

In the morning is the cheapest time of day to fly from Madrid to Santiago when you can find flight prices for as low as $1,265. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,689 per ticket.

Fly from Madrid Barajas to Santiago Arturo Merino Benitez for the best Madrid Barajas - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $1,122 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Madrid for as low as $1,033 on momondo.

There are 3 cabin classes available to choose from on Madrid to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines and Delta are the most popular carriers operating from Madrid Barajas to Santiago Arturo Merino Benitez

LATAM Airlines, Iberia and Avianca are the top three most popular airlines that fly to Santiago from Madrid according to our data. LATAM Airlines is the first choice among our users, with 54% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 16% of flights between Madrid and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 123 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 13% of their flights experiencing any sort of delay.

As of May 2026, 14 flights take off from Madrid and land in Santiago each day. The most common flight departure time for this route is 11:00PM, with 72% of daily flights taking off in the evening.

As of May 2026, there are 101 flights per week flying from Madrid to Santiago. The most common day of the week flights depart is Sun, with 18% of flights taking off on this day.