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Cheap flights from Louisville to Santo Domingo from $287

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Santo Domingo departing on 10/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Louisville to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:45 pm - 10:46 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
9h 01m1 stop Newark
United Airlines Logo
6:00 am - 5:37 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
12h 37m1 stop Newark
$600United Airlines
Tue, Oct 27 - Mon, Nov 2
United Airlines Logo
1:45 pm - 10:46 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
9h 01m1 stop Newark
United Airlines Logo
6:00 am - 8:52 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
15h 52m2 stops Newark Chicago O'Hare Intl
$605United Airlines
Tue, Oct 27 - Mon, Nov 2
American Airlines Logo
4:48 pm - 9:21 amSDF  Louisville Intl-SDQ Santo Domingo Las Americas
16h 33m2 stops Philadelphia Miami
American Airlines Logo
4:20 pm - 11:44 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
7h 24m1 stop Miami
$605American Airlines
Thu, Sep 24 - Thu, Oct 1
American Airlines Logo
4:48 pm - 9:21 amSDF  Louisville Intl-SDQ Santo Domingo Las Americas
16h 33m2 stops Philadelphia Miami
American Airlines Logo
4:20 pm - 9:43 amSDQ  Santo Domingo Las Americas-SDF Louisville Intl
17h 23m2 stops Miami Chicago O'Hare Intl
$605American Airlines
Thu, Sep 24 - Thu, Oct 1
United Airlines Logo
10:37 am - 10:46 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
12h 09m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
6:00 am - 6:32 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
13h 32m2 stops Newark Chicago O'Hare Intl
$605United Airlines
Tue, Oct 27 - Mon, Nov 2
Delta Logo
7:05 am - 1:27 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
6h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 9:59 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
7h 06m1 stop Atlanta Hartsfield-Jackson
$620Delta
Thu, Sep 24 - Thu, Oct 1
American Airlines Logo
6:00 am - 8:50 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
14h 50m2 stops Washington, D.C. Reagan-National Miami
American Airlines Logo
10:27 am - 10:07 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
11h 40m2 stops Miami Philadelphia
$625American Airlines
Fri, Oct 23 - Mon, Oct 26
Delta Logo
6:00 am - 1:32 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
7h 32m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:57 pm - 11:59 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
9h 02m1 stop Atlanta Hartsfield-Jackson
$640Delta
Fri, Oct 23 - Mon, Oct 26
Delta Logo
6:00 am - 1:27 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
7h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 9:59 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
7h 06m1 stop Atlanta Hartsfield-Jackson
$660Delta
Fri, Sep 18 - Sat, Oct 3
United Airlines Logo
1:15 pm - 10:46 pmSDF  Louisville Intl-SDQ Santo Domingo Las Americas
9h 31m1 stop Newark
United Airlines Logo
6:00 am - 5:17 pmSDQ  Santo Domingo Las Americas-SDF Louisville Intl
11h 17m1 stop Newark
$720United Airlines
Sun, Sep 6 - Sat, Sep 12

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American Airlines flights from Louisville to Santo Domingo

Our best American Airlines deals on Louisville to Santo Domingo flight tickets
American Airlines
Sep 24
SDF4:48 pmLouisville Intl
16h 33m
2 stops
SDQ9:21 amSanto Domingo Las Americas
Oct 1
SDQ4:20 pmSanto Domingo Las Americas
7h 24m
1 stop
SDF11:44 pmLouisville Intl
$605
American Airlines
Oct 23
SDF6:00 amLouisville Intl
14h 50m
2 stops
SDQ8:50 pmSanto Domingo Las Americas
Oct 26
SDQ10:27 amSanto Domingo Las Americas
11h 40m
2 stops
SDF10:07 pmLouisville Intl
$625
American Airlines
Sep 18
SDF7:27 pmLouisville Intl
17h 44m
2 stops
SDQ1:11 pmSanto Domingo Las Americas
Oct 3
SDQ2:15 pmSanto Domingo Las Americas
9h 29m
1 stop
SDF11:44 pmLouisville Intl
$665

Delta flights from Louisville to Santo Domingo

Our best Delta deals on Louisville to Santo Domingo flight tickets
Delta
Sep 24
SDF7:05 amLouisville Intl
6h 22m
1 stop
SDQ1:27 pmSanto Domingo Las Americas
Oct 1
SDQ2:53 pmSanto Domingo Las Americas
7h 06m
1 stop
SDF9:59 pmLouisville Intl
$620
Delta
Oct 23
SDF6:00 amLouisville Intl
7h 32m
1 stop
SDQ1:32 pmSanto Domingo Las Americas
Oct 26
SDQ2:57 pmSanto Domingo Las Americas
9h 02m
1 stop
SDF11:59 pmLouisville Intl
$640
Delta
Sep 18
SDF6:00 amLouisville Intl
7h 27m
1 stop
SDQ1:27 pmSanto Domingo Las Americas
Oct 3
SDQ2:53 pmSanto Domingo Las Americas
7h 06m
1 stop
SDF9:59 pmLouisville Intl
$660

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Louisville to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Tue 10/27

1:45 pm-10:46 pm

1 stop9h 01m

Santo Domingo Las Americas

Mon 11/2

6:00 am-5:37 pm

1 stop12h 37m

$600

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Tue 10/27

1:45 pm-10:46 pm

1 stop9h 01m

Santo Domingo Las Americas

Mon 11/2

6:00 am-8:52 pm

2 stops15h 52m

$605

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Thu 9/24

4:48 pm-9:21 am

2 stops16h 33m

Santo Domingo Las Americas

Thu 10/1

4:20 pm-11:44 pm

1 stop7h 24m

$605

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Thu 9/24

4:48 pm-9:21 am

2 stops16h 33m

Santo Domingo Las Americas

Thu 10/1

4:20 pm-9:43 am

2 stops17h 23m

$605

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Tue 10/27

10:37 am-10:46 pm

2 stops12h 09m

Santo Domingo Las Americas

Mon 11/2

6:00 am-6:32 pm

2 stops13h 32m

$605
Quickest round-trip

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Thu 9/24

7:05 am-1:27 pm

1 stop6h 22m

Santo Domingo Las Americas

Thu 10/1

2:53 pm-9:59 pm

1 stop7h 06m

$620

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Fri 10/23

6:00 am-8:50 pm

2 stops14h 50m

Santo Domingo Las Americas

Mon 10/26

10:27 am-10:07 pm

2 stops11h 40m

$625

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Fri 10/23

6:00 am-1:32 pm

1 stop7h 32m

Santo Domingo Las Americas

Mon 10/26

2:57 pm-11:59 pm

1 stop9h 02m

$640

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Fri 9/18

6:00 am-1:27 pm

1 stop7h 27m

Santo Domingo Las Americas

Sat 10/3

2:53 pm-9:59 pm

1 stop7h 06m

$660

LouisvilleSanto Domingo

SDF Louisville Intl - SDQ Santo Domingo Las Americas

SDFSDQ

Louisville Intl

Sun 9/6

1:15 pm-10:46 pm

1 stop9h 31m

Santo Domingo Las Americas

Sat 9/12

6:00 am-5:17 pm

1 stop11h 17m

$720

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Louisville to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until September to fly from Louisville, when ticket prices are also cheap, with an average price of $442.

When to book flights from Louisville to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Santo Domingo (SDF to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Santo Domingo

Fastest flight time

6h 23m

Direct flights

None
The fastest flight from Louisville to Santo Domingo takes 6h 23m
There are no direct flights from Louisville to Santo Domingo. There are no popular flight routes from Louisville to Santo Domingo.
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Frequently asked questions about flying from Louisville to Santo Domingo

  • How far is Louisville Intl to Santo Domingo Las Americas by plane?

    The distance between Louisville Intl and Santo Domingo Las Americas is about 1663.7 mi. In terms of flight time, this usually takes a little over 6h 23m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Louisville to Santo Domingo?

Best airlines flying from Louisville to Santo Domingo

Compare and see reviews for airlines that fly from Louisville to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $524Free CancellationRating
7.1
11,923 reviews
Search American Airlines flights
DeltaPriceFrom $568Free CancellationRating
7.8
8,502 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Santo Domingo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santo Domingo from Louisville.

Can I find flights from Louisville to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from Louisville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Louisville to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from Louisville.

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Of course. momondo tracks the price of Louisville to Santo Domingo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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