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Cheap flights from Louisville to Santo Domingo from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Santo Domingo departing on 4/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
6:06 pm - 1:29 pm
SDF
-
SDQ
19h 23m
1 stop
Spirit Airlines Logo
2:35 pm - 5:04 pm
SDQ
-
SDF
26h 29m
1 stop
$414Spirit Airlines
Fri, Apr 17 - Sun, Apr 19
Multiple Airlines Logo
12:24 pm - 1:29 pm
SDF
-
SDQ
25h 05m
1 stop
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$472Multiple Airlines
Wed, May 27 - Sun, May 31
Spirit Airlines Logo
6:06 pm - 1:29 pm
SDF
-
SDQ
19h 23m
1 stop
Spirit Airlines Logo
2:35 pm - 5:04 pm
SDQ
-
SDF
26h 29m
1 stop
$476Spirit Airlines
Sat, May 9 - Sat, May 16
Multiple Airlines Logo
12:24 pm - 1:29 pm
SDF
-
SDQ
25h 05m
1 stop
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$477Multiple Airlines
Wed, May 27 - Thu, Jun 4
Multiple Airlines Logo
8:06 pm - 11:12 pm
SDF
-
SDQ
27h 06m
2 stops
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$484Multiple Airlines
Wed, May 27 - Thu, Jun 4
Multiple Airlines Logo
6:55 pm - 1:29 pm
SDF
-
SDQ
18h 34m
2 stops
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$485Multiple Airlines
Thu, May 28 - Thu, Jun 4
Multiple Airlines Logo
12:24 pm - 1:29 pm
SDF
-
SDQ
25h 05m
1 stop
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$486Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
6:06 pm - 1:29 pm
SDF
-
SDQ
19h 23m
1 stop
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$490Multiple Airlines
Thu, May 28 - Thu, Jun 4
Multiple Airlines Logo
6:55 pm - 1:29 pm
SDF
-
SDQ
18h 34m
2 stops
Multiple Airlines Logo
2:35 pm - 8:20 pm
SDQ
-
SDF
29h 45m
1 stop
$496Multiple Airlines
Thu, May 28 - Thu, Jun 4
Multiple Airlines Logo
6:06 pm - 1:29 pm
SDF
-
SDQ
19h 23m
1 stop
Multiple Airlines Logo
2:35 pm - 6:15 pm
SDQ
-
SDF
27h 40m
2 stops
$502Multiple Airlines
Sat, May 9 - Sat, May 16

Spirit Airlines flights from Louisville to Santo Domingo

Our best Spirit Airlines deals on Louisville to Santo Domingo flight tickets
Spirit Airlines
Apr 17
SDF6:06 pmLouisville Intl
19h 23m
1 stop
SDQ1:29 pmSanto Domingo Las Americas
Apr 19
SDQ2:35 pmSanto Domingo Las Americas
26h 29m
1 stop
SDF5:04 pmLouisville Intl
$414
Spirit Airlines
May 9
SDF6:06 pmLouisville Intl
19h 23m
1 stop
SDQ1:29 pmSanto Domingo Las Americas
May 16
SDQ2:35 pmSanto Domingo Las Americas
26h 29m
1 stop
SDF5:04 pmLouisville Intl
$476
Spirit Airlines
May 28
SDF6:06 pmLouisville Intl
19h 23m
1 stop
SDQ1:29 pmSanto Domingo Las Americas
May 31
SDQ2:35 pmSanto Domingo Las Americas
26h 29m
1 stop
SDF5:04 pmLouisville Intl
$507

American Airlines flights from Louisville to Santo Domingo

Our best American Airlines deals on Louisville to Santo Domingo flight tickets
American Airlines
Apr 1
SDF7:40 amLouisville Intl
15h 13m
2 stops
SDQ10:53 pmSanto Domingo Las Americas
Apr 30
SDQ2:25 pmSanto Domingo Las Americas
18h 13m
2 stops
SDF8:38 amLouisville Intl
$698
American Airlines
Apr 1
SDF6:06 amLouisville Intl
10h 44m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Apr 30
SDQ2:25 pmSanto Domingo Las Americas
20h 05m
2 stops
SDF10:30 amLouisville Intl
$781
American Airlines
Apr 7
SDF6:41 pmLouisville Intl
18h 37m
2 stops
SDQ1:18 pmSanto Domingo Las Americas
Apr 12
SDQ4:00 pmSanto Domingo Las Americas
16h 38m
2 stops
SDF8:38 amLouisville Intl
$1,135

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Louisville to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Fri 4/17

6:06 pm-1:29 pm

1 stop19h 23m

Santo Domingo Las Americas

Sun 4/19

2:35 pm-5:04 pm

1 stop26h 29m

$414

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Wed 5/27

12:24 pm-1:29 pm

1 stop25h 05m

Santo Domingo Las Americas

Sun 5/31

2:35 pm-8:20 pm

1 stop29h 45m

$472

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Sat 5/9

6:06 pm-1:29 pm

1 stop19h 23m

Santo Domingo Las Americas

Sat 5/16

2:35 pm-5:04 pm

1 stop26h 29m

$476

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Wed 5/27

12:24 pm-1:29 pm

1 stop25h 05m

Santo Domingo Las Americas

Thu 6/4

2:35 pm-8:20 pm

1 stop29h 45m

$477

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Wed 5/27

8:06 pm-11:12 pm

2 stops27h 06m

Santo Domingo Las Americas

Thu 6/4

2:35 pm-8:20 pm

1 stop29h 45m

$484

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Thu 5/28

6:55 pm-1:29 pm

2 stops18h 34m

Santo Domingo Las Americas

Thu 6/4

2:35 pm-8:20 pm

1 stop29h 45m

$485

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Wed 5/27

12:24 pm-1:29 pm

1 stop25h 05m

Santo Domingo Las Americas

Sun 5/31

2:35 pm-8:20 pm

1 stop29h 45m

$486

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Thu 5/28

6:06 pm-1:29 pm

1 stop19h 23m

Santo Domingo Las Americas

Thu 6/4

2:35 pm-8:20 pm

1 stop29h 45m

$490

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Thu 5/28

6:55 pm-1:29 pm

2 stops18h 34m

Santo Domingo Las Americas

Thu 6/4

2:35 pm-8:20 pm

1 stop29h 45m

$496

LouisvilleSanto Domingo

SDF - SDQ

SDFSDQ

Louisville Intl

Sat 5/9

6:06 pm-1:29 pm

1 stop19h 23m

Santo Domingo Las Americas

Sat 5/16

2:35 pm-6:15 pm

2 stops27h 40m

$502

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Louisville to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Louisville and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until September to fly from Louisville, when ticket prices are also cheap, with an average price of $534.

Can stopping save me money on Louisville to Santo Domingo flights?

You could potentially save up to 3% on your flight if you consider stops on a Louisville to Santo Domingo flight.

When to book flights from Louisville to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Santo Domingo (SDF to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Santo Domingo

Fastest flight time

7h 12m

Direct flights

None
The fastest flight from Louisville to Santo Domingo takes 7h 12m
There are no direct flights from Louisville to Santo Domingo. There are no popular flight routes from Louisville to Santo Domingo.
Search flight deals

  • How far is Louisville Intl to Santo Domingo Las Americas by plane?

    The distance between Louisville Intl and Santo Domingo Las Americas is about 1663.7 mi. In terms of flight time, this usually takes a little over 7h 12m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Louisville to Santo Domingo?

Best airlines flying from Louisville to Santo Domingo

Compare and see reviews for airlines that fly from Louisville to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $517Free CancellationRating
7.1
11,495 reviews
Search American Airlines flights
DeltaPriceFrom $524Free CancellationRating
7.9
8,331 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Santo Domingo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santo Domingo from Louisville.

Can I find flights from Louisville to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from Louisville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Louisville to Santo Domingo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santo Domingo from Louisville.

I’m not ready to book a flight from Louisville to Santo Domingo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Louisville to Santo Domingo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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