Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Santiago from $542

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 1/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Santiago

Cheap round-trip flights

Logo
9:12 pm - 4:45 amTYS-SCL
31h 33m3 stops
Logo
4:11 am - 11:12 pmSCL-TYS
19h 01m2 stops
$680
Find Deal
Thu, Aug 21 - Mon, Aug 25
Logo
7:30 am - 5:02 amTYS-SCL
21h 32m2 stops
Logo
4:11 am - 11:12 pmSCL-TYS
19h 01m2 stops
$712
Find Deal
Thu, Aug 21 - Mon, Aug 25
American Airlines Logo
7:00 am - 6:55 amTYS-SCL
23h 55m1 stop
American Airlines Logo
9:55 pm - 11:46 pmSCL-TYS
25h 51m1 stop
$732American Airlines
Find Deal
Thu, Aug 21 - Mon, Aug 25
American Airlines Logo
12:56 pm - 6:55 amTYS-SCL
17h 59m2 stops
American Airlines Logo
9:55 pm - 11:46 pmSCL-TYS
25h 51m1 stop
$737American Airlines
Find Deal
Thu, Aug 21 - Mon, Aug 25
LATAM Airlines Logo
7:16 pm - 12:20 pmTYS-SCL
17h 04m2 stops
LATAM Airlines Logo
5:35 am - 11:48 pmSCL-TYS
18h 13m2 stops
$914LATAM Airlines
Find Deal
Mon, Aug 18 - Fri, Aug 22
LATAM Airlines Logo
7:16 pm - 12:20 pmTYS-SCL
17h 04m2 stops
LATAM Airlines Logo
5:35 am - 11:48 pmSCL-TYS
18h 13m2 stops
$934LATAM Airlines
Find Deal
Mon, Aug 18 - Fri, Aug 22
Delta Logo
7:16 pm - 7:00 amTYS-SCL
11h 44m1 stop
Delta Logo
4:55 pm - 1:08 pmSCL-TYS
20h 13m2 stops
$954Delta
Find Deal
Sun, Aug 17 - Sat, Aug 23
Copa Airlines Logo
7:25 pm - 7:24 pmTYS-SCL
23h 59m2 stops
Copa Airlines Logo
2:26 am - 8:56 pmSCL-TYS
18h 30m2 stops
$1,179Copa Airlines
Find Deal
Thu, Aug 21 - Sun, Aug 24
Copa Airlines Logo
5:45 am - 10:44 pmTYS-SCL
16h 59m2 stops
Copa Airlines Logo
12:13 am - 8:56 pmSCL-TYS
20h 43m2 stops
$1,277Copa Airlines
Find Deal
Mon, Aug 18 - Thu, Aug 21
Delta Logo
4:19 pm - 2:00 pmTYS-SCL
21h 41m2 stops
Delta Logo
8:40 pm - 10:42 amSCL-TYS
14h 02m1 stop
$3,034Delta
Find Deal
Tue, Aug 26 - Tue, Sep 2

LATAM Airlines flights from Knoxville to Santiago

Our best LATAM Airlines deals on Knoxville to Santiago flight tickets
LATAM Airlines
Aug 18
TYS7:16 pmKnoxville McGhee Tyson
17h 04m
2 stops
SCL12:20 pmSantiago Arturo Merino Benitez
Aug 22
SCL5:35 amSantiago Arturo Merino Benitez
18h 13m
2 stops
TYS11:48 pmKnoxville McGhee Tyson
$914
Find similar
LATAM Airlines
Aug 18
TYS7:16 pmKnoxville McGhee Tyson
17h 04m
2 stops
SCL12:20 pmSantiago Arturo Merino Benitez
Aug 22
SCL5:35 amSantiago Arturo Merino Benitez
18h 13m
2 stops
TYS11:48 pmKnoxville McGhee Tyson
$934
Find similar
LATAM Airlines
Aug 18
TYS7:16 pmKnoxville McGhee Tyson
11h 44m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Aug 22
SCL4:55 pmSantiago Arturo Merino Benitez
17h 32m
2 stops
TYS10:27 amKnoxville McGhee Tyson
$1,254
Find similar

Copa Airlines flights from Knoxville to Santiago

Our best Copa Airlines deals on Knoxville to Santiago flight tickets
Copa Airlines
Aug 21
TYS7:25 pmKnoxville McGhee Tyson
23h 59m
2 stops
SCL7:24 pmSantiago Arturo Merino Benitez
Aug 24
SCL2:26 amSantiago Arturo Merino Benitez
18h 30m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
$1,179
Find similar
Copa Airlines
Aug 18
TYS5:45 amKnoxville McGhee Tyson
16h 59m
2 stops
SCL10:44 pmSantiago Arturo Merino Benitez
Aug 21
SCL12:13 amSantiago Arturo Merino Benitez
20h 43m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
$1,277
Find similar
Copa Airlines
Aug 18
TYS5:45 amKnoxville McGhee Tyson
16h 59m
2 stops
SCL10:44 pmSantiago Arturo Merino Benitez
Aug 21
SCL12:24 amSantiago Arturo Merino Benitez
20h 32m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
$1,477
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/21

9:12 pm-4:45 am

3 stops31h 33m

Santiago Arturo Merino Benitez

Mon 8/25

4:11 am-11:12 pm

2 stops19h 01m

$680

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/21

7:30 am-5:02 am

2 stops21h 32m

Santiago Arturo Merino Benitez

Mon 8/25

4:11 am-11:12 pm

2 stops19h 01m

$712

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/21

7:00 am-6:55 am

1 stop23h 55m

Santiago Arturo Merino Benitez

Mon 8/25

9:55 pm-11:46 pm

1 stop25h 51m

$732

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/21

12:56 pm-6:55 am

2 stops17h 59m

Santiago Arturo Merino Benitez

Mon 8/25

9:55 pm-11:46 pm

1 stop25h 51m

$737

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 8/18

7:16 pm-12:20 pm

2 stops17h 04m

Santiago Arturo Merino Benitez

Fri 8/22

5:35 am-11:48 pm

2 stops18h 13m

$914

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 8/18

7:16 pm-12:20 pm

2 stops17h 04m

Santiago Arturo Merino Benitez

Fri 8/22

5:35 am-11:48 pm

2 stops18h 13m

$934

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 8/17

7:16 pm-7:00 am

1 stop11h 44m

Santiago Arturo Merino Benitez

Sat 8/23

4:55 pm-1:08 pm

2 stops20h 13m

$954

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/21

7:25 pm-7:24 pm

2 stops23h 59m

Santiago Arturo Merino Benitez

Sun 8/24

2:26 am-8:56 pm

2 stops18h 30m

$1,179

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 8/18

5:45 am-10:44 pm

2 stops16h 59m

Santiago Arturo Merino Benitez

Thu 8/21

12:13 am-8:56 pm

2 stops20h 43m

$1,277

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/26

4:19 pm-2:00 pm

2 stops21h 41m

Santiago Arturo Merino Benitez

Tue 9/2

8:40 pm-10:42 am

1 stop14h 02m

$3,034

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $801. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Thursday is $1,459.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Knoxville to Santiago when you can find flight prices for as low as $970. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,327 per ticket.

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Best Price Found

$542

Fastest flight time

11h 44m

Direct flights

None

Airports in Santiago

1 airport
The best one-way flight to Santiago from Knoxville in the past 72 hours is $542. The best round-trip flight deal from Knoxville to Santiago found on momondo in the last 72 hours is $680.
The fastest flight from Knoxville to Santiago takes 11h 44m
There are no direct flights from Knoxville to Santiago. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - Santiago Arturo Merino Benitez Airport.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 11h 44m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Best airlines flying from Knoxville to Santiago

Compare and see reviews for airlines that fly from Knoxville to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $692Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Santiago trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 8/7
Thu 8/14
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Chile