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Cheap flights from Knoxville to Santiago from $900

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:29 pm - 8:05 am
TYS
-
SCL
13h 36m
1 stop
American Airlines Logo
10:15 pm - 11:30 am
SCL
-
TYS
14h 15m
1 stop
$900American Airlines
Fri, Mar 6 - Fri, Mar 13
American Airlines Logo
4:29 pm - 8:05 am
TYS
-
SCL
13h 36m
1 stop
American Airlines Logo
9:20 pm - 4:15 pm
SCL
-
TYS
19h 55m
2 stops
$905American Airlines
Fri, Mar 6 - Fri, Mar 13
LATAM Airlines Logo
6:41 pm - 5:35 am
TYS
-
SCL
32h 54m
2 stops
LATAM Airlines Logo
10:35 am - 11:18 am
SCL
-
TYS
25h 43m
2 stops
$935LATAM Airlines
Fri, Mar 6 - Fri, Mar 13
LATAM Airlines Logo
5:00 pm - 3:30 pm
TYS
-
SCL
20h 30m
2 stops
LATAM Airlines Logo
11:10 pm - 11:08 am
SCL
-
TYS
13h 58m
1 stop
$1,003LATAM Airlines
Wed, Feb 4 - Fri, Feb 13
LATAM Airlines Logo
4:06 pm - 7:40 am
TYS
-
SCL
13h 34m
1 stop
LATAM Airlines Logo
10:35 am - 11:52 pm
SCL
-
TYS
15h 17m
2 stops
$1,009LATAM Airlines
Fri, Feb 6 - Sat, Feb 14
United Airlines Logo
4:55 pm - 8:50 am
TYS
-
SCL
13h 55m
1 stop
United Airlines Logo
10:45 pm - 1:46 pm
SCL
-
TYS
17h 01m
1 stop
$1,011United Airlines
Wed, Feb 4 - Fri, Feb 13
LATAM Airlines Logo
11:58 am - 6:45 am
TYS
-
SCL
16h 47m
2 stops
LATAM Airlines Logo
6:30 pm - 11:08 am
SCL
-
TYS
18h 38m
2 stops
$1,043LATAM Airlines
Fri, Feb 6 - Sat, Feb 14
LATAM Airlines Logo
4:06 pm - 7:40 am
TYS
-
SCL
13h 34m
1 stop
LATAM Airlines Logo
11:10 pm - 9:24 am
SCL
-
TYS
12h 14m
1 stop
$1,051LATAM Airlines
Fri, Feb 6 - Sat, Feb 14
LATAM Airlines Logo
12:00 pm - 2:25 pm
TYS
-
SCL
24h 25m
3 stops
LATAM Airlines Logo
7:15 am - 11:18 am
SCL
-
TYS
29h 03m
3 stops
$1,073LATAM Airlines
Fri, Mar 6 - Fri, Mar 13
LATAM Airlines Logo
4:06 pm - 2:25 pm
TYS
-
SCL
20h 19m
3 stops
LATAM Airlines Logo
10:35 am - 11:52 pm
SCL
-
TYS
15h 17m
2 stops
$1,373LATAM Airlines
Fri, Feb 6 - Sat, Feb 14

American Airlines flights from Knoxville to Santiago

Our best American Airlines deals on Knoxville to Santiago flight tickets
American Airlines
Mar 6
TYS4:29 pmKnoxville McGhee Tyson
13h 36m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Mar 13
SCL10:15 pmSantiago Arturo Merino Benitez
14h 15m
1 stop
TYS11:30 amKnoxville McGhee Tyson
$900
American Airlines
Mar 6
TYS4:29 pmKnoxville McGhee Tyson
13h 36m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Mar 13
SCL9:20 pmSantiago Arturo Merino Benitez
19h 55m
2 stops
TYS4:15 pmKnoxville McGhee Tyson
$905

LATAM Airlines flights from Knoxville to Santiago

Our best LATAM Airlines deals on Knoxville to Santiago flight tickets
LATAM Airlines
Mar 6
TYS6:41 pmKnoxville McGhee Tyson
32h 54m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 13
SCL10:35 amSantiago Arturo Merino Benitez
25h 43m
2 stops
TYS11:18 amKnoxville McGhee Tyson
$935
LATAM Airlines
Feb 4
TYS5:00 pmKnoxville McGhee Tyson
20h 30m
2 stops
SCL3:30 pmSantiago Arturo Merino Benitez
Feb 13
SCL11:10 pmSantiago Arturo Merino Benitez
13h 58m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$1,003
LATAM Airlines
Feb 6
TYS4:06 pmKnoxville McGhee Tyson
13h 34m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Feb 14
SCL10:35 amSantiago Arturo Merino Benitez
15h 17m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
$1,009

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

4:29 pm-8:05 am

1 stop13h 36m

Santiago Arturo Merino Benitez

Fri 3/13

10:15 pm-11:30 am

1 stop14h 15m

$900

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

4:29 pm-8:05 am

1 stop13h 36m

Santiago Arturo Merino Benitez

Fri 3/13

9:20 pm-4:15 pm

2 stops19h 55m

$905

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

6:41 pm-5:35 am

2 stops32h 54m

Santiago Arturo Merino Benitez

Fri 3/13

10:35 am-11:18 am

2 stops25h 43m

$935

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 2/4

5:00 pm-3:30 pm

2 stops20h 30m

Santiago Arturo Merino Benitez

Fri 2/13

11:10 pm-11:08 am

1 stop13h 58m

$1,003

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/6

4:06 pm-7:40 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Sat 2/14

10:35 am-11:52 pm

2 stops15h 17m

$1,009

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 2/4

4:55 pm-8:50 am

1 stop13h 55m

Santiago Arturo Merino Benitez

Fri 2/13

10:45 pm-1:46 pm

1 stop17h 01m

$1,011

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/6

11:58 am-6:45 am

2 stops16h 47m

Santiago Arturo Merino Benitez

Sat 2/14

6:30 pm-11:08 am

2 stops18h 38m

$1,043

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/6

4:06 pm-7:40 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Sat 2/14

11:10 pm-9:24 am

1 stop12h 14m

$1,051

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

12:00 pm-2:25 pm

3 stops24h 25m

Santiago Arturo Merino Benitez

Fri 3/13

7:15 am-11:18 am

3 stops29h 03m

$1,073

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 2/6

4:06 pm-2:25 pm

3 stops20h 19m

Santiago Arturo Merino Benitez

Sat 2/14

10:35 am-11:52 pm

2 stops15h 17m

$1,373

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Santiago?

American Airlines, LATAM Airlines and Delta are the top three most popular airlines that fly to Santiago from Knoxville according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Fastest flight time

13h 55m

Direct flights

None
The fastest flight from Knoxville to Santiago takes 13h 55m
There are no direct flights from Knoxville to Santiago. There are no popular flight routes from Knoxville to Santiago.
Search flight deals

  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 13h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Best airlines flying from Knoxville to Santiago

Compare and see reviews for airlines that fly from Knoxville to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $678Free CancellationRating
7.2
11,174 reviews
Search American Airlines flights
DeltaPriceFrom $714Free CancellationRating
7.9
8,089 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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