Cheap flights from Knoxville to Santiago from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 10/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
12:00 pm - 7:50 am
TYS
-
SCL
18h 50m
1 stop
United Airlines Logo
10:45 pm - 1:20 pm
SCL
-
TYS
16h 35m
1 stop
$945United Airlines
Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
7:40 pm - 7:05 am
TYS
-
SCL
11h 25m
1 stop
American Airlines Logo
8:50 pm - 7:10 pm
SCL
-
TYS
22h 20m
1 stop
$947American Airlines
Thu, Aug 6 - Thu, Aug 20
United Airlines Logo
8:26 am - 7:50 am
TYS
-
SCL
22h 24m
2 stops
United Airlines Logo
10:45 pm - 1:20 pm
SCL
-
TYS
16h 35m
1 stop
$950United Airlines
Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
7:40 pm - 7:05 am
TYS
-
SCL
11h 25m
1 stop
American Airlines Logo
8:50 pm - 7:01 pm
SCL
-
TYS
22h 11m
2 stops
$952American Airlines
Thu, Aug 6 - Thu, Aug 20
American Airlines Logo
4:46 pm - 8:50 am
TYS
-
SCL
15h 04m
2 stops
American Airlines Logo
9:30 pm - 3:52 pm
SCL
-
TYS
19h 22m
2 stops
$954American Airlines
Fri, Sep 25 - Sun, Oct 4
American Airlines Logo
7:13 am - 9:00 am
TYS
-
SCL
24h 47m
1 stop
American Airlines Logo
10:15 pm - 11:45 pm
SCL
-
TYS
27h 30m
1 stop
$980American Airlines
Thu, Oct 29 - Sat, Nov 7
United Airlines Logo
9:15 am - 7:50 am
TYS
-
SCL
21h 35m
1 stop
United Airlines Logo
10:45 pm - 11:37 pm
SCL
-
TYS
26h 52m
2 stops
$981United Airlines
Thu, Oct 29 - Sat, Nov 7
American Airlines Logo
4:02 pm - 9:00 am
TYS
-
SCL
15h 58m
2 stops
American Airlines Logo
10:15 pm - 2:19 pm
SCL
-
TYS
18h 04m
2 stops
$984American Airlines
Thu, Oct 29 - Sat, Nov 7
American Airlines Logo
10:08 am - 7:05 am
TYS
-
SCL
20h 57m
2 stops
American Airlines Logo
8:50 pm - 3:57 pm
SCL
-
TYS
19h 07m
2 stops
$1,009American Airlines
Thu, Aug 6 - Thu, Aug 20
American Airlines Logo
2:43 pm - 8:50 am
TYS
-
SCL
17h 07m
2 stops
American Airlines Logo
9:30 pm - 12:56 pm
SCL
-
TYS
16h 26m
2 stops
$1,033American Airlines
Wed, Sep 30 - Fri, Oct 9

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United Airlines flights from Knoxville to Santiago

Our best United Airlines deals on Knoxville to Santiago flight tickets
United Airlines
Oct 27
TYS12:00 pmKnoxville McGhee Tyson
18h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Nov 10
SCL10:45 pmSantiago Arturo Merino Benitez
16h 35m
1 stop
TYS1:20 pmKnoxville McGhee Tyson
$945
United Airlines
Oct 27
TYS2:00 pmKnoxville McGhee Tyson
16h 50m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
Nov 10
SCL10:45 pmSantiago Arturo Merino Benitez
22h 32m
2 stops
TYS7:17 pmKnoxville McGhee Tyson
$950
United Airlines
Oct 29
TYS9:15 amKnoxville McGhee Tyson
21h 35m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Nov 7
SCL10:45 pmSantiago Arturo Merino Benitez
26h 52m
2 stops
TYS11:37 pmKnoxville McGhee Tyson
$981

American Airlines flights from Knoxville to Santiago

Our best American Airlines deals on Knoxville to Santiago flight tickets
American Airlines
Aug 6
TYS7:40 pmKnoxville McGhee Tyson
11h 25m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
Aug 20
SCL8:50 pmSantiago Arturo Merino Benitez
22h 20m
1 stop
TYS7:10 pmKnoxville McGhee Tyson
$947
American Airlines
Aug 6
TYS7:40 pmKnoxville McGhee Tyson
11h 25m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
Aug 20
SCL8:50 pmSantiago Arturo Merino Benitez
22h 11m
2 stops
TYS7:01 pmKnoxville McGhee Tyson
$952
American Airlines
Sep 25
TYS6:15 amKnoxville McGhee Tyson
25h 35m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Oct 4
SCL9:30 pmSantiago Arturo Merino Benitez
19h 22m
2 stops
TYS3:52 pmKnoxville McGhee Tyson
$954

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 10/27

12:00 pm-7:50 am

1 stop18h 50m

Santiago Arturo Merino Benitez

Tue 11/10

10:45 pm-1:20 pm

1 stop16h 35m

$945

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/6

7:40 pm-7:05 am

1 stop11h 25m

Santiago Arturo Merino Benitez

Thu 8/20

8:50 pm-7:10 pm

1 stop22h 20m

$947

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 10/27

8:26 am-7:50 am

2 stops22h 24m

Santiago Arturo Merino Benitez

Tue 11/10

10:45 pm-1:20 pm

1 stop16h 35m

$950

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/6

7:40 pm-7:05 am

1 stop11h 25m

Santiago Arturo Merino Benitez

Thu 8/20

8:50 pm-7:01 pm

2 stops22h 11m

$952

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 9/25

4:46 pm-8:50 am

2 stops15h 04m

Santiago Arturo Merino Benitez

Sun 10/4

9:30 pm-3:52 pm

2 stops19h 22m

$954

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/29

7:13 am-9:00 am

1 stop24h 47m

Santiago Arturo Merino Benitez

Sat 11/7

10:15 pm-11:45 pm

1 stop27h 30m

$980

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/29

9:15 am-7:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Sat 11/7

10:45 pm-11:37 pm

2 stops26h 52m

$981

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/29

4:02 pm-9:00 am

2 stops15h 58m

Santiago Arturo Merino Benitez

Sat 11/7

10:15 pm-2:19 pm

2 stops18h 04m

$984

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/6

10:08 am-7:05 am

2 stops20h 57m

Santiago Arturo Merino Benitez

Thu 8/20

8:50 pm-3:57 pm

2 stops19h 07m

$1,009
Quickest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

2:43 pm-8:50 am

2 stops17h 07m

Santiago Arturo Merino Benitez

Fri 10/9

9:30 pm-12:56 pm

2 stops16h 26m

$1,033

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez?

American Airlines is the most popular carrier operating from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Fastest flight time

13h 30m

Direct flights

None
The fastest flight from Knoxville to Santiago takes 13h 30m
There are no direct flights from Knoxville to Santiago. There are no popular flight routes from Knoxville to Santiago.

Frequently asked questions about flying from Knoxville to Santiago

  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 13h 30m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Mon 7/13
Mon 7/20

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