Cheap flights from Knoxville to Santiago from $869

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 8/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
4:00 pm - 7:45 pm
TYS
-
SCL
51h 45m
2 stops
LATAM Airlines Logo
8:40 pm - 6:17 pm
SCL
-
TYS
21h 37m
1 stop
$869LATAM Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
1:19 pm - 6:50 am
TYS
-
SCL
17h 31m
2 stops
American Airlines Logo
8:30 pm - 2:58 pm
SCL
-
TYS
18h 28m
2 stops
$870American Airlines
Sat, Aug 1 - Wed, Aug 12
LATAM Airlines Logo
4:00 pm - 7:45 pm
TYS
-
SCL
51h 45m
2 stops
LATAM Airlines Logo
6:00 pm - 11:47 pm
SCL
-
TYS
29h 47m
3 stops
$874LATAM Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
6:00 am - 6:50 am
TYS
-
SCL
24h 50m
1 stop
American Airlines Logo
8:30 pm - 6:40 pm
SCL
-
TYS
22h 10m
1 stop
$875American Airlines
Sat, Aug 1 - Mon, Aug 10
United Airlines Logo
11:40 am - 7:50 am
TYS
-
SCL
19h 10m
1 stop
United Airlines Logo
9:45 pm - 7:55 pm
SCL
-
TYS
23h 10m
1 stop
$1,245United Airlines
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
7:00 am - 7:50 am
TYS
-
SCL
23h 50m
3 stops
United Airlines Logo
9:45 pm - 4:45 pm
SCL
-
TYS
20h 00m
2 stops
$1,250United Airlines
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
11:40 am - 7:50 am
TYS
-
SCL
19h 10m
1 stop
United Airlines Logo
9:45 pm - 6:10 pm
SCL
-
TYS
21h 25m
1 stop
$1,295United Airlines
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
7:00 am - 7:50 am
TYS
-
SCL
23h 50m
3 stops
United Airlines Logo
9:45 pm - 2:50 pm
SCL
-
TYS
18h 05m
2 stops
$1,300United Airlines
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
4:55 pm - 7:50 am
TYS
-
SCL
13h 55m
1 stop
United Airlines Logo
9:45 pm - 7:55 pm
SCL
-
TYS
23h 10m
1 stop
$1,335United Airlines
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
7:00 am - 7:50 am
TYS
-
SCL
23h 50m
3 stops
United Airlines Logo
9:45 pm - 2:50 pm
SCL
-
TYS
18h 05m
2 stops
$1,340United Airlines
Mon, Mar 23 - Wed, Mar 25

LATAM Airlines flights from Knoxville to Santiago

Our best LATAM Airlines deals on Knoxville to Santiago flight tickets
LATAM Airlines
Aug 1
TYS4:00 pmKnoxville McGhee Tyson
51h 45m
2 stops
SCL7:45 pmSantiago Arturo Merino Benitez
Aug 12
SCL8:40 pmSantiago Arturo Merino Benitez
21h 37m
1 stop
TYS6:17 pmKnoxville McGhee Tyson
$869
LATAM Airlines
Aug 1
TYS4:00 pmKnoxville McGhee Tyson
51h 45m
2 stops
SCL7:45 pmSantiago Arturo Merino Benitez
Aug 10
SCL6:00 pmSantiago Arturo Merino Benitez
24h 17m
3 stops
TYS6:17 pmKnoxville McGhee Tyson
$874

American Airlines flights from Knoxville to Santiago

Our best American Airlines deals on Knoxville to Santiago flight tickets
American Airlines
Aug 1
TYS1:19 pmKnoxville McGhee Tyson
17h 31m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
Aug 12
SCL8:30 pmSantiago Arturo Merino Benitez
18h 28m
2 stops
TYS2:58 pmKnoxville McGhee Tyson
$870
American Airlines
Aug 1
TYS6:00 amKnoxville McGhee Tyson
24h 50m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Aug 12
SCL8:30 pmSantiago Arturo Merino Benitez
22h 10m
1 stop
TYS6:40 pmKnoxville McGhee Tyson
$875

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 8/1

4:00 pm-7:45 pm

2 stops51h 45m

Santiago Arturo Merino Benitez

Wed 8/12

8:40 pm-6:17 pm

1 stop21h 37m

$869
Quickest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 8/1

1:19 pm-6:50 am

2 stops17h 31m

Santiago Arturo Merino Benitez

Wed 8/12

8:30 pm-2:58 pm

2 stops18h 28m

$870

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 8/1

4:00 pm-7:45 pm

2 stops51h 45m

Santiago Arturo Merino Benitez

Wed 8/12

6:00 pm-11:47 pm

3 stops29h 47m

$874

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sat 8/1

6:00 am-6:50 am

1 stop24h 50m

Santiago Arturo Merino Benitez

Mon 8/10

8:30 pm-6:40 pm

1 stop22h 10m

$875

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

11:40 am-7:50 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-7:55 pm

1 stop23h 10m

$1,245

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

7:00 am-7:50 am

3 stops23h 50m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-4:45 pm

2 stops20h 00m

$1,250

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

11:40 am-7:50 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-6:10 pm

1 stop21h 25m

$1,295

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

7:00 am-7:50 am

3 stops23h 50m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-2:50 pm

2 stops18h 05m

$1,300

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

4:55 pm-7:50 am

1 stop13h 55m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-7:55 pm

1 stop23h 10m

$1,335

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/23

7:00 am-7:50 am

3 stops23h 50m

Santiago Arturo Merino Benitez

Wed 3/25

9:45 pm-2:50 pm

2 stops18h 05m

$1,340

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Santiago?

American Airlines, LATAM Airlines and Delta are the top three most popular airlines that fly to Santiago from Knoxville according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Fastest flight time

13h 55m

Direct flights

None
The fastest flight from Knoxville to Santiago takes 13h 55m
There are no direct flights from Knoxville to Santiago. There are no popular flight routes from Knoxville to Santiago.
  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 13h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Best airlines flying from Knoxville to Santiago

Compare and see reviews for airlines that fly from Knoxville to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $714Free CancellationRating
7.1
11,419 reviews
Search American Airlines flights
DeltaPriceFrom $714Free CancellationRating
7.9
8,278 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Fri 4/10
Fri 4/17

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