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Cheap flights from Knoxville to Santiago from $714

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 3/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
2:38 pm - 7:40 am
TYS
-
SCL
16h 02m1 stop
LATAM Airlines Logo
5:15 am - 11:51 pm
SCL
-
TYS
19h 36m2 stops
$714LATAM Airlines
Thu, Mar 19 - Mon, Mar 23
LATAM Airlines Logo
2:38 pm - 2:10 pm
TYS
-
SCL
22h 32m3 stops
LATAM Airlines Logo
10:10 pm - 11:18 am
SCL
-
TYS
14h 08m1 stop
$719LATAM Airlines
Thu, Mar 19 - Mon, Mar 23
United Airlines Logo
7:00 am - 7:50 am
TYS
-
SCL
23h 50m3 stops
United Airlines Logo
9:45 pm - 8:47 pm
SCL
-
TYS
24h 02m2 stops
$769United Airlines
Thu, Mar 19 - Mon, Mar 23
LATAM Airlines Logo
12:00 pm - 7:00 am
TYS
-
SCL
17h 00m2 stops
LATAM Airlines Logo
6:52 pm - 11:51 pm
SCL
-
TYS
53h 59m3 stops
$890LATAM Airlines
Fri, Mar 6 - Sat, Mar 14
Delta Logo
12:00 pm - 7:00 am
TYS
-
SCL
17h 00m2 stops
Delta Logo
10:10 pm - 11:51 pm
SCL
-
TYS
26h 41m1 stop
$1,039Delta
Fri, Mar 6 - Sat, Mar 14
American Airlines Logo
4:30 pm - 7:55 am
TYS
-
SCL
13h 25m1 stop
American Airlines Logo
10:15 pm - 11:31 am
SCL
-
TYS
14h 16m1 stop
$1,184American Airlines
Fri, Mar 6 - Sat, Mar 14
LATAM Airlines Logo
11:58 am - 6:35 am
TYS
-
SCL
16h 37m2 stops
LATAM Airlines Logo
6:40 am - 11:52 pm
SCL
-
TYS
19h 12m2 stops
$3,160LATAM Airlines
Mon, Feb 2 - Fri, Feb 13
United Airlines Logo
7:20 pm - 8:50 am
TYS
-
SCL
35h 30m2 stops
United Airlines Logo
10:45 pm - 1:46 pm
SCL
-
TYS
17h 01m1 stop
$3,399United Airlines
Mon, Feb 2 - Fri, Feb 13
American Airlines Logo
5:24 pm - 9:00 am
TYS
-
SCL
13h 36m1 stop
American Airlines Logo
10:25 pm - 11:55 pm
SCL
-
TYS
27h 30m1 stop
$3,418American Airlines
Mon, Feb 2 - Fri, Feb 13
American Airlines Logo
11:19 am - 9:00 am
TYS
-
SCL
19h 41m2 stops
American Airlines Logo
10:25 pm - 11:55 pm
SCL
-
TYS
27h 30m1 stop
$3,422American Airlines
Mon, Feb 2 - Fri, Feb 13

United Airlines flights from Knoxville to Santiago

Our best United Airlines deals on Knoxville to Santiago flight tickets
United Airlines
Mar 19
TYS7:00 amKnoxville McGhee Tyson
23h 50m
3 stops
SCL7:50 amSantiago Arturo Merino Benitez
Mar 23
SCL9:45 pmSantiago Arturo Merino Benitez
24h 02m
2 stops
TYS8:47 pmKnoxville McGhee Tyson
$769
Find similar
United Airlines
Feb 2
TYS7:20 pmKnoxville McGhee Tyson
35h 30m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Feb 13
SCL10:45 pmSantiago Arturo Merino Benitez
17h 01m
1 stop
TYS1:46 pmKnoxville McGhee Tyson
$3,399
Find similar

American Airlines flights from Knoxville to Santiago

Our best American Airlines deals on Knoxville to Santiago flight tickets
American Airlines
Mar 6
TYS4:30 pmKnoxville McGhee Tyson
13h 25m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Mar 14
SCL10:15 pmSantiago Arturo Merino Benitez
14h 16m
1 stop
TYS11:31 amKnoxville McGhee Tyson
$1,184
Find similar
American Airlines
Feb 2
TYS5:24 pmKnoxville McGhee Tyson
13h 36m
1 stop
SCL9:00 amSantiago Arturo Merino Benitez
Feb 13
SCL10:25 pmSantiago Arturo Merino Benitez
27h 30m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$3,418
Find similar
American Airlines
Feb 2
TYS11:19 amKnoxville McGhee Tyson
19h 41m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Feb 13
SCL10:25 pmSantiago Arturo Merino Benitez
27h 30m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$3,422
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

2:38 pm-7:40 am

1 stop16h 02m

Santiago Arturo Merino Benitez

Mon 3/23

5:15 am-11:51 pm

2 stops19h 36m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

2:38 pm-2:10 pm

3 stops22h 32m

Santiago Arturo Merino Benitez

Mon 3/23

10:10 pm-11:18 am

1 stop14h 08m

$719

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

7:00 am-7:50 am

3 stops23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-8:47 pm

2 stops24h 02m

$769

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

12:00 pm-7:00 am

2 stops17h 00m

Santiago Arturo Merino Benitez

Sat 3/14

6:52 pm-11:51 pm

3 stops53h 59m

$890

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

12:00 pm-7:00 am

2 stops17h 00m

Santiago Arturo Merino Benitez

Sat 3/14

10:10 pm-11:51 pm

1 stop26h 41m

$1,039

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

4:30 pm-7:55 am

1 stop13h 25m

Santiago Arturo Merino Benitez

Sat 3/14

10:15 pm-11:31 am

1 stop14h 16m

$1,184

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/2

11:58 am-6:35 am

2 stops16h 37m

Santiago Arturo Merino Benitez

Fri 2/13

6:40 am-11:52 pm

2 stops19h 12m

$3,160

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/2

7:20 pm-8:50 am

2 stops35h 30m

Santiago Arturo Merino Benitez

Fri 2/13

10:45 pm-1:46 pm

1 stop17h 01m

$3,399

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/2

5:24 pm-9:00 am

1 stop13h 36m

Santiago Arturo Merino Benitez

Fri 2/13

10:25 pm-11:55 pm

1 stop27h 30m

$3,418

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/2

11:19 am-9:00 am

2 stops19h 41m

Santiago Arturo Merino Benitez

Fri 2/13

10:25 pm-11:55 pm

1 stop27h 30m

$3,422

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $801. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Thursday is $1,459.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Knoxville to Santiago when you can find flight prices for as low as $970. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,327 per ticket.

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Fastest flight time

13h 55m

Direct flights

None
The fastest flight from Knoxville to Santiago takes 13h 55m
There are no direct flights from Knoxville to Santiago. There are no popular flight routes from Knoxville to Santiago.
Search flight deals

  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 13h 25m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Best airlines flying from Knoxville to Santiago

Compare and see reviews for airlines that fly from Knoxville to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $678Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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