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Cheap flights from Knoxville to Santiago from $714

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santiago departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
5:36 pm - 9:05 amTYS-SCL
13h 29m1 stop
American Airlines Logo
11:15 pm - 3:46 pmSCL-TYS
18h 31m1 stop
$714American Airlines
Find Deal
Thu, Jan 22 - Tue, Feb 3
American Airlines Logo
4:44 pm - 7:50 amTYS-SCL
13h 06m1 stop
American Airlines Logo
10:15 pm - 3:46 pmSCL-TYS
19h 31m2 stops
$719American Airlines
Find Deal
Thu, Jan 22 - Tue, Feb 3
LATAM Airlines Logo
12:00 pm - 7:00 amTYS-SCL
17h 00m1 stop
LATAM Airlines Logo
4:35 am - 11:44 pmSCL-TYS
21h 09m2 stops
$824LATAM Airlines
Find Deal
Thu, Jan 22 - Mon, Feb 2
American Airlines Logo
12:10 pm - 7:45 amTYS-SCL
17h 35m1 stop
American Airlines Logo
11:55 pm - 5:06 pmSCL-TYS
19h 11m1 stop
$1,212American Airlines
Find Deal
Tue, Dec 9 - Mon, Jan 5
American Airlines Logo
12:35 pm - 8:55 amTYS-SCL
18h 20m2 stops
American Airlines Logo
10:25 pm - 5:06 pmSCL-TYS
20h 41m1 stop
$1,217American Airlines
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Tue, Dec 9 - Mon, Jan 5
United Airlines Logo
4:59 pm - 8:50 amTYS-SCL
13h 51m1 stop
United Airlines Logo
10:45 pm - 4:53 pmSCL-TYS
20h 08m2 stops
$1,231United Airlines
Find Deal
Tue, Dec 9 - Tue, Jan 6
United Airlines Logo
1:52 pm - 8:50 amTYS-SCL
16h 58m2 stops
United Airlines Logo
10:45 pm - 2:49 pmSCL-TYS
18h 04m2 stops
$1,281United Airlines
Find Deal
Wed, Dec 10 - Tue, Jan 6
Delta Logo
3:56 pm - 7:40 amTYS-SCL
13h 44m1 stop
Delta Logo
11:15 pm - 3:06 pmSCL-TYS
17h 51m1 stop
$1,342Delta
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Tue, Dec 9 - Tue, Jan 6
LATAM Airlines Logo
7:10 am - 2:20 pmTYS-SCL
29h 10m2 stops
LATAM Airlines Logo
11:25 pm - 11:44 pmSCL-TYS
26h 19m2 stops
$1,347LATAM Airlines
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Tue, Dec 9 - Mon, Jan 5
Delta Logo
10:23 am - 7:40 amTYS-SCL
19h 17m1 stop
Delta Logo
9:30 pm - 1:26 pmSCL-TYS
17h 56m1 stop
$1,912Delta
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Mon, Dec 8 - Sun, Jan 4

United Airlines flights from Knoxville to Santiago

Our best United Airlines deals on Knoxville to Santiago flight tickets
United Airlines
Dec 9
TYS4:59 pmKnoxville McGhee Tyson
13h 51m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Jan 6
SCL10:45 pmSantiago Arturo Merino Benitez
20h 08m
2 stops
TYS4:53 pmKnoxville McGhee Tyson
$1,231
Find similar
United Airlines
Dec 10
TYS1:52 pmKnoxville McGhee Tyson
16h 58m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Jan 6
SCL10:45 pmSantiago Arturo Merino Benitez
18h 04m
2 stops
TYS2:49 pmKnoxville McGhee Tyson
$1,281
Find similar
United Airlines
Dec 9
TYS10:50 amKnoxville McGhee Tyson
20h 00m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Jan 5
SCL10:45 pmSantiago Arturo Merino Benitez
18h 04m
2 stops
TYS2:49 pmKnoxville McGhee Tyson
$1,338
Find similar

Delta flights from Knoxville to Santiago

Our best Delta deals on Knoxville to Santiago flight tickets
Delta
Dec 9
TYS3:56 pmKnoxville McGhee Tyson
13h 44m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Jan 6
SCL11:15 pmSantiago Arturo Merino Benitez
17h 51m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
$1,342
Find similar
Delta
Dec 8
TYS10:23 amKnoxville McGhee Tyson
19h 17m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Jan 4
SCL9:30 pmSantiago Arturo Merino Benitez
17h 56m
1 stop
TYS1:26 pmKnoxville McGhee Tyson
$1,912
Find similar
Delta
Oct 17
TYS7:11 amKnoxville McGhee Tyson
22h 49m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Oct 24
SCL9:40 pmSantiago Arturo Merino Benitez
13h 48m
1 stop
TYS10:28 amKnoxville McGhee Tyson
$7,125
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 1/22

5:36 pm-9:05 am

1 stop13h 29m

Santiago Arturo Merino Benitez

Tue 2/3

11:15 pm-3:46 pm

1 stop18h 31m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 1/22

4:44 pm-7:50 am

1 stop13h 06m

Santiago Arturo Merino Benitez

Tue 2/3

10:15 pm-3:46 pm

2 stops19h 31m

$719

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 1/22

12:00 pm-7:00 am

1 stop17h 00m

Santiago Arturo Merino Benitez

Mon 2/2

4:35 am-11:44 pm

2 stops21h 09m

$824

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

12:10 pm-7:45 am

1 stop17h 35m

Santiago Arturo Merino Benitez

Mon 1/5

11:55 pm-5:06 pm

1 stop19h 11m

$1,212

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

12:35 pm-8:55 am

2 stops18h 20m

Santiago Arturo Merino Benitez

Mon 1/5

10:25 pm-5:06 pm

1 stop20h 41m

$1,217

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

4:59 pm-8:50 am

1 stop13h 51m

Santiago Arturo Merino Benitez

Tue 1/6

10:45 pm-4:53 pm

2 stops20h 08m

$1,231

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 12/10

1:52 pm-8:50 am

2 stops16h 58m

Santiago Arturo Merino Benitez

Tue 1/6

10:45 pm-2:49 pm

2 stops18h 04m

$1,281

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

3:56 pm-7:40 am

1 stop13h 44m

Santiago Arturo Merino Benitez

Tue 1/6

11:15 pm-3:06 pm

1 stop17h 51m

$1,342

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

7:10 am-2:20 pm

2 stops29h 10m

Santiago Arturo Merino Benitez

Mon 1/5

11:25 pm-11:44 pm

2 stops26h 19m

$1,347

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 12/8

10:23 am-7:40 am

1 stop19h 17m

Santiago Arturo Merino Benitez

Sun 1/4

9:30 pm-1:26 pm

1 stop17h 56m

$1,912

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from Knoxville to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $801. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Thursday is $1,459.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Knoxville to Santiago when you can find flight prices for as low as $970. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,327 per ticket.

When to book flights from Knoxville to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santiago (TYS to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santiago

Direct flights

None
There are no direct flights from Knoxville to Santiago. There are no popular flight routes from Knoxville to Santiago.
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  • How far is Knoxville McGhee Tyson to Santiago Arturo Merino Benitez by plane?

    A flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez will travel around 4868.2 mi. A reasonable flight in good conditions will take 12h 01m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santiago?

Best airlines flying from Knoxville to Santiago

Compare and see reviews for airlines that fly from Knoxville to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $678Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $778Free CancellationRating
7.5
1,866 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santiago?

It is quick and easy to find Knoxville to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Knoxville to Santiago with flexible booking policies on momondo?

All flight searches from Knoxville to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Santiago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago from Knoxville.

I’m not ready to book a flight from Knoxville to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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