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Cheap flights from Knoxville to Brussels from $485

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Brussels departing on 2/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
2:25 pm - 1:15 pm
TYS
-
BRU
16h 50m2 stops
United Airlines Logo
10:00 am - 8:52 pm
BRU
-
TYS
40h 52m2 stops
$485United Airlines
Wed, Feb 4 - Sun, Feb 8
Lufthansa Logo
1:59 pm - 8:55 am
TYS
-
BRU
12h 56m1 stop
Lufthansa Logo
11:55 am - 7:27 pm
BRU
-
TYS
13h 32m1 stop
$487Lufthansa
Sat, Jan 31 - Sat, Feb 7
United Airlines Logo
1:59 pm - 8:55 am
TYS
-
BRU
12h 56m1 stop
United Airlines Logo
10:00 am - 8:52 pm
BRU
-
TYS
40h 52m2 stops
$488United Airlines
Wed, Feb 4 - Sun, Feb 8
United Airlines Logo
7:00 am - 7:10 am
TYS
-
BRU
18h 10m2 stops
United Airlines Logo
9:25 am - 10:29 pm
BRU
-
TYS
43h 04m2 stops
$491United Airlines
Wed, Apr 8 - Wed, Apr 22
Lufthansa Logo
2:25 pm - 7:15 am
TYS
-
BRU
10h 50m1 stop
Lufthansa Logo
7:00 am - 7:27 pm
BRU
-
TYS
18h 27m2 stops
$493Lufthansa
Sat, Jan 31 - Sat, Feb 7
Lufthansa Logo
2:25 pm - 7:15 am
TYS
-
BRU
10h 50m1 stop
Lufthansa Logo
10:30 am - 8:52 pm
BRU
-
TYS
16h 22m2 stops
$494Lufthansa
Sat, Jan 31 - Sat, Feb 7
Lufthansa Logo
2:25 pm - 10:20 am
TYS
-
BRU
13h 55m2 stops
Lufthansa Logo
7:00 am - 7:27 pm
BRU
-
TYS
18h 27m2 stops
$500Lufthansa
Sat, Jan 31 - Sat, Feb 7
Lufthansa Logo
2:25 pm - 10:20 am
TYS
-
BRU
13h 55m2 stops
Lufthansa Logo
7:00 am - 7:27 pm
BRU
-
TYS
18h 27m2 stops
$501Lufthansa
Sat, Jan 31 - Sat, Feb 7
Multiple Airlines Logo
7:20 pm - 7:50 am
TYS
-
BRU
30h 30m2 stops
Multiple Airlines Logo
11:55 am - 7:29 pm
BRU
-
TYS
13h 34m1 stop
$502Multiple Airlines
Sun, Feb 8 - Sun, Feb 15
United Airlines Logo
11:10 am - 8:55 am
TYS
-
BRU
15h 45m1 stop
United Airlines Logo
10:10 am - 4:53 pm
BRU
-
TYS
12h 43m1 stop
$508United Airlines
Wed, Feb 4 - Sun, Feb 8

Lufthansa flights from Knoxville to Brussels Bruxelles-National Airport

Our best Lufthansa deals on Knoxville to Brussels Bruxelles-National Airport flight tickets
Lufthansa
Feb 10
TYS1:59 pmKnoxville McGhee Tyson
12h 56m
1 stop
BRU8:55 amBrussels Bruxelles-National
Feb 17
BRU10:30 amBrussels Bruxelles-National
16h 07m
2 stops
TYS8:37 pmKnoxville McGhee Tyson
$448
Find similar
Lufthansa
Feb 10
TYS1:59 pmKnoxville McGhee Tyson
12h 56m
1 stop
BRU8:55 amBrussels Bruxelles-National
Feb 17
BRU11:55 amBrussels Bruxelles-National
13h 34m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
$456
Find similar
Lufthansa
Jan 31
TYS1:59 pmKnoxville McGhee Tyson
12h 56m
1 stop
BRU8:55 amBrussels Bruxelles-National
Feb 7
BRU11:55 amBrussels Bruxelles-National
13h 32m
1 stop
TYS7:27 pmKnoxville McGhee Tyson
$487
Find similar

Air Canada flights from Knoxville to Brussels Bruxelles-National Airport

Our best Air Canada deals on Knoxville to Brussels Bruxelles-National Airport flight tickets
Air Canada
Feb 10
TYS2:25 pmKnoxville McGhee Tyson
16h 50m
3 stops
BRU1:15 pmBrussels Bruxelles-National
Feb 17
BRU7:00 amBrussels Bruxelles-National
18h 29m
3 stops
TYS7:29 pmKnoxville McGhee Tyson
$525
Find similar
Air Canada
Jan 31
TYS2:25 pmKnoxville McGhee Tyson
16h 50m
3 stops
BRU1:15 pmBrussels Bruxelles-National
Feb 7
BRU7:00 amBrussels Bruxelles-National
18h 27m
3 stops
TYS7:27 pmKnoxville McGhee Tyson
$621
Find similar
Air Canada
Jan 31
TYS2:25 pmKnoxville McGhee Tyson
16h 50m
3 stops
BRU1:15 pmBrussels Bruxelles-National
Feb 7
BRU7:00 amBrussels Bruxelles-National
18h 27m
3 stops
TYS7:27 pmKnoxville McGhee Tyson
$719
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Knoxville to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/4

2:25 pm-1:15 pm

2 stops16h 50m

Brussels Bruxelles-National

Sun 2/8

10:00 am-8:52 pm

2 stops40h 52m

$485

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sat 1/31

1:59 pm-8:55 am

1 stop12h 56m

Brussels Bruxelles-National

Sat 2/7

11:55 am-7:27 pm

1 stop13h 32m

$487

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/4

1:59 pm-8:55 am

1 stop12h 56m

Brussels Bruxelles-National

Sun 2/8

10:00 am-8:52 pm

2 stops40h 52m

$488

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 4/8

7:00 am-7:10 am

2 stops18h 10m

Brussels Bruxelles-National

Wed 4/22

9:25 am-10:29 pm

2 stops43h 04m

$491

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sat 1/31

2:25 pm-7:15 am

1 stop10h 50m

Brussels Bruxelles-National

Sat 2/7

7:00 am-7:27 pm

2 stops18h 27m

$493

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sat 1/31

2:25 pm-7:15 am

1 stop10h 50m

Brussels Bruxelles-National

Sat 2/7

10:30 am-8:52 pm

2 stops16h 22m

$494

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sat 1/31

2:25 pm-10:20 am

2 stops13h 55m

Brussels Bruxelles-National

Sat 2/7

7:00 am-7:27 pm

2 stops18h 27m

$500

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sat 1/31

2:25 pm-10:20 am

2 stops13h 55m

Brussels Bruxelles-National

Sat 2/7

7:00 am-7:27 pm

2 stops18h 27m

$501

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Sun 2/8

7:20 pm-7:50 am

2 stops30h 30m

Brussels Bruxelles-National

Sun 2/15

11:55 am-7:29 pm

1 stop13h 34m

$502

KnoxvilleBrussels

TYS - BRU

TYSBRU

Knoxville McGhee Tyson

Wed 2/4

11:10 am-8:55 am

1 stop15h 45m

Brussels Bruxelles-National

Sun 2/8

10:10 am-4:53 pm

1 stop12h 43m

$508

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Brussels from

How to get the cheapest flight ticket from Knoxville to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Knoxville to Brussels Bruxelles-National Airport is on a Tuesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Tuesday will often find tickets for as low as $912. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Brussels Bruxelles-National Airport for around $1,355.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the afternoon. Flights from Knoxville to Brussels Bruxelles-National Airport during this time can be as low as $949. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $1,105 on average. Flights to Brussels Bruxelles-National Airport from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Knoxville to Brussels Bruxelles-National Airport flights?

You could potentially save up to 15% on your flight if you consider stops on a Knoxville to Brussels Bruxelles-National Airport flight.

When to book flights from Knoxville to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Brussels Bruxelles-National Airport (TYS to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Brussels Bruxelles-National Airport

Fastest flight time

12h 56m

Direct flights

None
The fastest flight from Knoxville to Brussels Bruxelles-National Airport takes 12h 56m
There are no direct flights from Knoxville to Brussels Bruxelles-National Airport. There are no popular flight routes from Knoxville to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Knoxville McGhee Tyson to Brussels Bruxelles-National by plane?

    Knoxville McGhee Tyson and Brussels Bruxelles-National are 4278.7 mi apart from one another. In terms of flight time, this usually takes a little over 12h 56m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Brussels Bruxelles-National Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The necessary travel and health documents for your Brussels Bruxelles-National Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Brussels Bruxelles-National Airport?

Best airlines flying from Knoxville to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Knoxville to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $603Free CancellationRating
7.4
9,113 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Charleroi
Hasselt
Spa
Zaventem
Namur
Dinant
Genk
Mons
Durbuy
Waterloo
Aalst
Mechelen
Francorchamps
Knokke-Heist
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Brussels?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Brussels. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Brussels with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Brussels from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Brussels?

momondo helps you find the best flight between Knoxville and Brussels by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Brussels right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Brussels flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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