Cheap flights from Indiana to the Cayman Islands from $75

If you aren’t able to travel to Cayman Islands during the month of January, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $500.

You are more likely to see cheaper flights to Cayman Islands from Indiana when booking weeks ahead of your departure date. In general, you can expect to find flights to Cayman Islands for around $582 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cayman Islands from Indiana for as low as $395 on momondo.

Spirit Airlines, Southwest, and United Airlines are the most popular carriers operating from Indiana to Cayman Islands

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Cayman Islands from Indiana according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Cayman Islands. Keep in mind that there are 4 different airlines that fly to Cayman Islands on a routine basis, so you have a few additional options to choose from.

As of February 2026, 11 flights take off from Indiana and land in Cayman Islands each week. The most common flight departure day for this route is Mon, with 18% of weekly flights taking off on this day.

Flight times vary depending on what airport in Indiana you fly out of and what airport in Cayman Islands you fly into. For example, flying from Fort Wayne to George Town takes 6h 29m on average. On the other hand, flying from Indianapolis to George Town takes 6h 30m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.