Cheap flights from Illinois to Panama City from $301

In general, April is the cheapest month to fly from Illinois to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $584. If you’re not able to fly to Panama City in April, then March is your next best option. Flight prices from Illinois to Panama City during March average around $601.

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $572. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $655. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Illinois to Panama City during this time can be as low as $531. Try not to purchase tickets in the morning because they tend to be around $620. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Illinois - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Illinois when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $757 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Illinois for as low as $619 on momondo.

There are 3 cabin classes available to choose from on Illinois to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

American Airlines is the most popular carrier operating from Illinois to Panama City Tocumen Intl

Copa Airlines, Avianca and United Airlines are the top three most popular airlines that fly to Panama City from Illinois according to our data. Copa Airlines is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

As of October 2026, there are 3 flights per day flying from Illinois to Panama City. The most common time of day flights depart is 8:00AM, with 60% of flights taking off at noon.

As of October 2026, 21 flights take off from Illinois and land in Panama City each week. The most common flight departure day for this route is Mon, with 24% of weekly flights taking off on this day.