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Cheap flights from Illinois to Panama City from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Illinois to Panama City departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Illinois to Panama City

Cheap round-trip flights

Delta Logo
6:00 am - 12:50 pmSTL-PTY
6h 50m1 stop
Delta Logo
2:10 pm - 10:00 pmPTY-STL
7h 50m1 stop
$393Delta
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Tue, Sep 9 - Tue, Sep 16
Logo
5:05 am - 12:10 amORD-PTY
19h 05m2 stops
Logo
5:25 pm - 10:48 pmPTY-ORD
29h 23m2 stops
$398
Find Deal
Tue, Sep 9 - Tue, Sep 23
United Airlines Logo
7:04 pm - 6:37 pmSTL-PTY
23h 33m2 stops
United Airlines Logo
10:00 am - 6:58 pmPTY-STL
8h 58m1 stop
$398United Airlines
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Wed, Sep 10 - Wed, Sep 17
Logo
5:05 am - 9:10 pmORD-PTY
16h 05m2 stops
Logo
3:20 am - 10:48 pmPTY-ORD
19h 28m2 stops
$404
Find Deal
Thu, Sep 18 - Sun, Sep 21
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 2:19 pmPTY-STL
22h 49m2 stops
$415United Airlines
Find Deal
Fri, Sep 12 - Tue, Sep 16
American Airlines Logo
4:36 pm - 2:31 pmSTL-PTY
21h 55m2 stops
American Airlines Logo
3:31 pm - 10:09 amPTY-STL
18h 38m2 stops
$420American Airlines
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Thu, Oct 2 - Sun, Oct 5
Avianca Logo
2:35 pm - 12:45 amORD-PTY
10h 10m1 stop
Avianca Logo
3:20 am - 1:15 pmPTY-ORD
9h 55m1 stop
$428Avianca
Find Deal
Fri, Sep 12 - Sun, Sep 21
Copa Airlines Logo
8:02 am - 1:22 pmORD-PTY
5h 20mnonstop
Copa Airlines Logo
7:55 am - 1:41 pmPTY-ORD
5h 46mnonstop
$451Copa Airlines
Find Deal
Thu, Sep 18 - Mon, Sep 22
Avianca Logo
2:35 pm - 8:55 amORD-PTY
18h 20m1 stop
Avianca Logo
5:25 pm - 1:15 pmPTY-ORD
19h 50m1 stop
$457Avianca
Find Deal
Fri, Sep 12 - Fri, Sep 19
American Airlines Logo
6:09 am - 2:31 pmORD-PTY
8h 22m1 stop
American Airlines Logo
3:31 pm - 4:46 pmPTY-ORD
25h 15m1 stop
$464American Airlines
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Fri, Sep 26 - Fri, Oct 3

Delta flights from Illinois to Panama City

Our best Delta deals on Illinois to Panama City flight tickets
Delta
Sep 9
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
Sep 16
PTY2:10 pmPanama City Tocumen Intl
7h 50m
1 stop
STL10:00 pmLambert-St Louis
$393
Find similar
Delta
Sep 12
STL6:01 amLambert-St Louis
6h 54m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 16
PTY2:10 pmPanama City Tocumen Intl
7h 50m
1 stop
STL10:00 pmLambert-St Louis
$410
Find similar
Delta
Nov 29
STL10:51 amLambert-St Louis
8h 10m
1 stop
PTY8:01 pmPanama City Tocumen Intl
Dec 6
PTY8:05 amPanama City Tocumen Intl
10h 57m
1 stop
STL6:02 pmLambert-St Louis
$427
Find similar

Avianca flights from Illinois to Panama City

Our best Avianca deals on Illinois to Panama City flight tickets
Avianca
Sep 12
ORD2:35 pmChicago O'Hare Intl
10h 10m
1 stop
PTY12:45 amPanama City Tocumen Intl
Sep 21
PTY3:20 amPanama City Tocumen Intl
9h 55m
1 stop
ORD1:15 pmChicago O'Hare Intl
$428
Find similar
Avianca
Sep 12
ORD2:35 pmChicago O'Hare Intl
18h 20m
1 stop
PTY8:55 amPanama City Tocumen Intl
Sep 19
PTY5:25 pmPanama City Tocumen Intl
19h 50m
1 stop
ORD1:15 pmChicago O'Hare Intl
$457
Find similar
Avianca
Sep 8
ORD2:35 pmChicago O'Hare Intl
18h 20m
1 stop
PTY8:55 amPanama City Tocumen Intl
Sep 11
PTY3:20 amPanama City Tocumen Intl
9h 55m
1 stop
ORD1:15 pmChicago O'Hare Intl
$481
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Illinois to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-10:00 pm

1 stop7h 50m

$393

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Tue 9/9

5:05 am-12:10 am

2 stops19h 05m

Panama City Tocumen Intl

Tue 9/23

5:25 pm-10:48 pm

2 stops29h 23m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/10

7:04 pm-6:37 pm

2 stops23h 33m

Panama City Tocumen Intl

Wed 9/17

10:00 am-6:58 pm

1 stop8h 58m

$398

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 9/18

5:05 am-9:10 pm

2 stops16h 05m

Panama City Tocumen Intl

Sun 9/21

3:20 am-10:48 pm

2 stops19h 28m

$404

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 9/16

3:30 pm-2:19 pm

2 stops22h 49m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/2

4:36 pm-2:31 pm

2 stops21h 55m

Panama City Tocumen Intl

Sun 10/5

3:31 pm-10:09 am

2 stops18h 38m

$420

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 9/12

2:35 pm-12:45 am

1 stop10h 10m

Panama City Tocumen Intl

Sun 9/21

3:20 am-1:15 pm

1 stop9h 55m

$428

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 9/18

8:02 am-1:22 pm

Nonstop5h 20m

Panama City Tocumen Intl

Mon 9/22

7:55 am-1:41 pm

Nonstop5h 46m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 9/12

2:35 pm-8:55 am

1 stop18h 20m

Panama City Tocumen Intl

Fri 9/19

5:25 pm-1:15 pm

1 stop19h 50m

$457

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 9/26

6:09 am-2:31 pm

1 stop8h 22m

Panama City Tocumen Intl

Fri 10/3

3:31 pm-4:46 pm

1 stop25h 15m

$464

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Illinois to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Illinois to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $464. If you’re not able to fly to Panama City in November, then September is your next best option. Flight prices from Illinois to Panama City during September average around $479.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $535. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $620. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Illinois to Panama City during this time can be as low as $518. Try not to purchase tickets at noon because they tend to be around $603. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Illinois to Panama City Tocumen Intl flight route?

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Illinois - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Illinois when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $573 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Illinois for as low as $509 on momondo.

What cabin class options are available on Illinois to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Illinois to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Illinois to Panama City flights?

You could potentially save up to 53% on your flight if you consider stops on a Illinois to Panama City flight.

Cheap Illinois to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Illinois to Panama City

Best Price Found

$164

Fastest flight time

5h 20m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Illinois in the past 72 hours is $164. The best round-trip flight deal from Illinois to Panama City found on momondo in the last 72 hours is $393.
The fastest flight from Illinois to Panama City takes 5h 20m
Direct flights go from Illinois to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • When did momondo last update prices for flights from Illinois to Panama City Tocumen Intl Airport?

    Prices for flights from Illinois to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Illinois to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Illinois to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Illinois to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Illinois to Panama City?

Best airlines flying from Illinois to Panama City

Compare and see reviews for airlines that fly from Illinois to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $339Free CancellationRating
6.7
2,399 reviews
Search Avianca flights
Copa AirlinesPriceFrom $464Free CancellationRating
7.5
1,507 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $478Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $478Free CancellationRating
8.0
7,980 reviews
Search Delta flights
United AirlinesPriceFrom $478Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Illinois to Panama City?

Finding the right flight to Panama City from Illinois is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Illinois to Panama City with flexible booking policies on momondo?

Flights from Illinois to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Illinois to Panama City?

momondo helps you find the best flight between Illinois and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Illinois to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Illinois to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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