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Cheap flights from Illinois to Panama City from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Illinois to Panama City departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Illinois to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 2:45 pm
STL
-
PTY
7h 45m1 stop
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$394United Airlines
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:25 am - 8:02 pm
STL
-
PTY
12h 37m2 stops
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$398United Airlines
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:00 am - 7:38 pm
STL
-
PTY
12h 38m1 stop
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$411United Airlines
Mon, Feb 23 - Sat, Feb 28
American Airlines Logo
6:56 pm - 3:15 pm
STL
-
PTY
19h 19m2 stops
American Airlines Logo
4:05 pm - 12:29 pm
PTY
-
STL
21h 24m2 stops
$437American Airlines
Sat, Feb 21 - Sun, Mar 1
Multiple Airlines Logo
6:57 pm - 8:40 am
ORD
-
PTY
12h 43m1 stop
Multiple Airlines Logo
9:33 pm - 9:39 am
PTY
-
ORD
13h 06m1 stop
$479Multiple Airlines
Mon, Feb 9 - Wed, Feb 18
Multiple Airlines Logo
9:23 am - 8:50 am
ORD
-
PTY
22h 27m2 stops
Multiple Airlines Logo
11:25 am - 11:47 pm
PTY
-
ORD
13h 22m2 stops
$483Multiple Airlines
Tue, Feb 3 - Tue, Feb 24
American Airlines Logo
4:51 pm - 1:27 pm
EVV
-
PTY
19h 36m2 stops
American Airlines Logo
4:50 pm - 11:37 am
PTY
-
EVV
19h 47m2 stops
$566American Airlines
Mon, Feb 2 - Mon, Feb 9
Delta Logo
6:40 pm - 1:55 pm
MDW
-
PTY
18h 15m1 stop
Delta Logo
3:20 pm - 10:42 pm
PTY
-
MDW
8h 22m1 stop
$604Delta
Fri, Feb 20 - Sun, Mar 1
Delta Logo
9:33 am - 1:55 pm
MDW
-
PTY
27h 22m2 stops
Delta Logo
3:20 pm - 5:37 pm
PTY
-
MDW
27h 17m2 stops
$608Delta
Mon, Feb 9 - Tue, Feb 17
WestJet Logo
6:00 am - 8:20 am
EVV
-
PTY
26h 20m2 stops
WestJet Logo
9:20 am - 4:56 pm
PTY
-
EVV
31h 36m2 stops
$5,179WestJet
Sat, Apr 18 - Tue, Apr 21

United Airlines flights from Illinois to Panama City

Our best United Airlines deals on Illinois to Panama City flight tickets
United Airlines
Feb 17
STL6:00 amLambert-St Louis
7h 45m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Feb 25
PTY4:41 pmPanama City Tocumen Intl
17h 42m
1 stop
STL9:23 amLambert-St Louis
$394
Find similar
United Airlines
Apr 21
STL6:00 amLambert-St Louis
10h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Apr 25
PTY7:55 amPanama City Tocumen Intl
8h 13m
1 stop
STL4:08 pmLambert-St Louis
$411
Find similar
United Airlines
Apr 21
STL6:30 amLambert-St Louis
13h 01m
2 stops
PTY7:31 pmPanama City Tocumen Intl
Apr 25
PTY7:55 amPanama City Tocumen Intl
8h 13m
1 stop
STL4:08 pmLambert-St Louis
$415
Find similar

American Airlines flights from Illinois to Panama City

Our best American Airlines deals on Illinois to Panama City flight tickets
American Airlines
Apr 29
STL5:35 amLambert-St Louis
6h 40m
1 stop
PTY12:15 pmPanama City Tocumen Intl
May 6
PTY1:55 pmPanama City Tocumen Intl
19h 45m
2 stops
STL9:40 amLambert-St Louis
$398
Find similar
American Airlines
Feb 21
STL6:56 pmLambert-St Louis
19h 19m
2 stops
PTY3:15 pmPanama City Tocumen Intl
Mar 1
PTY4:05 pmPanama City Tocumen Intl
21h 24m
2 stops
STL12:29 pmLambert-St Louis
$437
Find similar
American Airlines
Mar 13
STL3:51 pmLambert-St Louis
20h 49m
2 stops
PTY12:40 pmPanama City Tocumen Intl
Mar 18
PTY3:13 pmPanama City Tocumen Intl
21h 15m
2 stops
STL12:28 pmLambert-St Louis
$463
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Illinois to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:25 am-8:02 pm

2 stops12h 37m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 2/23

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Sat 2/28

4:41 pm-9:23 am

1 stop17h 42m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 2/21

6:56 pm-3:15 pm

2 stops19h 19m

Panama City Tocumen Intl

Sun 3/1

4:05 pm-12:29 pm

2 stops21h 24m

$437

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Mon 2/9

6:57 pm-8:40 am

1 stop12h 43m

Panama City Tocumen Intl

Wed 2/18

9:33 pm-9:39 am

1 stop13h 06m

$479

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Tue 2/3

9:23 am-8:50 am

2 stops22h 27m

Panama City Tocumen Intl

Tue 2/24

11:25 am-11:47 pm

2 stops13h 22m

$483

EvansvillePanama City

EVV - PTY

EVVPTY

Evansville Dress Regional

Mon 2/2

4:51 pm-1:27 pm

2 stops19h 36m

Panama City Tocumen Intl

Mon 2/9

4:50 pm-11:37 am

2 stops19h 47m

$566

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Fri 2/20

6:40 pm-1:55 pm

1 stop18h 15m

Panama City Tocumen Intl

Sun 3/1

3:20 pm-10:42 pm

1 stop8h 22m

$604

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Mon 2/9

9:33 am-1:55 pm

2 stops27h 22m

Panama City Tocumen Intl

Tue 2/17

3:20 pm-5:37 pm

2 stops27h 17m

$608

EvansvillePanama City

EVV - PTY

EVVPTY

Evansville Dress Regional

Sat 4/18

6:00 am-8:20 am

2 stops26h 20m

Panama City Tocumen Intl

Tue 4/21

9:20 am-4:56 pm

2 stops31h 36m

$5,179

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Illinois to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from Illinois to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $523. If you’re not able to fly to Panama City in July, then September is your next best option. Flight prices from Illinois to Panama City during September average around $548.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $530. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $585. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Illinois to Panama City during this time can be as low as $496. Try not to purchase tickets in the morning because they tend to be around $578. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Illinois to Panama City Tocumen Intl flight route?

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Illinois - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Illinois when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $584 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Illinois for as low as $538 on momondo.

What cabin class options are available on Illinois to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Illinois to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Illinois to Panama City flights?

You could potentially save up to 34% on your flight if you consider stops on a Illinois to Panama City flight.

Cheap Illinois to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Illinois to Panama City

Best Price Found

$201

Fastest flight time

5h 13m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Illinois in the past 72 hours is $201. The best round-trip flight deal from Illinois to Panama City found on momondo in the last 72 hours is $437.
The fastest flight from Illinois to Panama City takes 5h 13m
Direct flights go from Illinois to Panama City every day.
There is 1 airport in Panama City. From Illinois there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • When did momondo last update prices for flights from Illinois to Panama City Tocumen Intl Airport?

    Prices for flights from Illinois to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Illinois to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Illinois to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Illinois to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Illinois to Panama City?

Best airlines flying from Illinois to Panama City

Compare and see reviews for airlines that fly from Illinois to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $358Free CancellationRating
6.6
2,488 reviews
Search Avianca flights
Copa AirlinesPriceFrom $464Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $479Free CancellationRating
7.4
9,100 reviews
Search United Airlines flights
DeltaPriceFrom $479Free CancellationRating
7.9
8,017 reviews
Search Delta flights
American AirlinesPriceFrom $589Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Illinois to Panama City?

Finding the right flight to Panama City from Illinois is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Illinois to Panama City with flexible booking policies on momondo?

Flights from Illinois to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Illinois to Panama City?

momondo helps you find the best flight between Illinois and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Illinois to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Illinois to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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