What is the cheapest airline that flies from Des Moines to Panama?

American Airlines and United Airlines are the most popular carriers operating from Des Moines to Panama

When did momondo last update prices for flights from Des Moines Airport to Panama?

Prices for flights from Des Moines Airport to Panama were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Panama?

As of December 2025, there are 2 operators available to choose from for flights from Des Moines Airport to Panama.

How old do you have to be to fly from Des Moines Airport to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.

What documentation or ID do you need to fly to Panama?

The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$198 Cheap Flights from Des Moines to Panama in 2025/26

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Cheap round-trip flights

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8:10 am - 7:38 pm

DSM

PTY

10h 28m1 stop

8:55 am - 10:30 pm

PTY

DSM

14h 35m1 stop

$453United Airlines

Tue, Jan 27 - Tue, Feb 3

8:10 am - 7:38 pm

DSM

PTY

10h 28m1 stop

8:55 am - 10:30 pm

PTY

DSM

14h 35m1 stop

$462United Airlines

Tue, Jan 27 - Tue, Feb 3

6:48 pm - 5:07 pm

DSM

PTY

21h 19m2 stops

8:55 am - 9:50 pm

PTY

DSM

13h 55m2 stops

$466United Airlines

Tue, Jan 27 - Tue, Feb 3

8:10 am - 5:07 pm

DSM

PTY

7h 57m1 stop

4:41 pm - 10:30 pm

PTY

DSM

30h 49m1 stop

$471United Airlines

Sun, Jan 11 - Thu, Jan 22

8:10 am - 5:07 pm

DSM

PTY

7h 57m1 stop

11:35 am - 10:30 pm

PTY

DSM

11h 55m1 stop

$504United Airlines

Thu, Jan 22 - Thu, Jan 29

6:30 am - 3:38 pm

DSM

PTY

8h 08m1 stop

2:27 pm - 11:29 pm

PTY

DSM

10h 02m1 stop

$505American Airlines

Mon, Jan 26 - Mon, Feb 2

6:46 pm - 5:07 pm

DSM

PTY

21h 21m2 stops

3:41 pm - 2:22 pm

PTY

DSM

22h 41m2 stops

$508United Airlines

Mon, Dec 29 - Mon, Mar 23

8:10 am - 7:38 pm

DSM

PTY

10h 28m1 stop

4:41 pm - 2:17 pm

PTY

DSM

22h 36m1 stop

$514United Airlines

Sun, Feb 8 - Sat, Feb 14

3:35 pm - 2:45 pm

DSM

PTY

22h 10m2 stops

4:41 pm - 2:17 pm

PTY

DSM

22h 36m1 stop

$518United Airlines

Sun, Feb 8 - Sat, Feb 14

6:45 pm - 4:12 pm

DSM

PTY

21h 27m2 stops

10:55 pm - 9:52 pm

PTY

DSM

22h 57m2 stops

$550United Airlines

Wed, Apr 22 - Sun, Apr 26

United Airlines flights from Des Moines to Panama

Our best United Airlines deals on Des Moines to Panama flight tickets

United Airlines

Jan 27

DSM8:10 amDes Moines

10h 28m

1 stop

PTY7:38 pmPanama City Tocumen Intl

Feb 3

PTY8:55 amPanama City Tocumen Intl

14h 35m

1 stop

DSM10:30 pmDes Moines

$453

Find similar

United Airlines

Jan 27

DSM8:10 amDes Moines

10h 28m

1 stop

PTY7:38 pmPanama City Tocumen Intl

Feb 3

PTY8:55 amPanama City Tocumen Intl

14h 35m

1 stop

DSM10:30 pmDes Moines

$462

Find similar

United Airlines

Jan 27

DSM6:48 pmDes Moines

21h 19m

2 stops

PTY5:07 pmPanama City Tocumen Intl

Feb 3

PTY8:55 amPanama City Tocumen Intl

27h 00m

2 stops

DSM10:55 amDes Moines

$466

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 1/27

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Tue 2/3

8:55 am-10:30 pm

1 stop14h 35m

$453

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 1/27

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Tue 2/3

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 1/27

6:48 pm-5:07 pm

2 stops21h 19m

Panama City Tocumen Intl

Tue 2/3

8:55 am-9:50 pm

2 stops13h 55m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 1/11

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Thu 1/22

4:41 pm-10:30 pm

1 stop30h 49m

$471

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/22

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Thu 1/29

11:35 am-10:30 pm

1 stop11h 55m

$504

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 1/26

6:30 am-3:38 pm

1 stop8h 08m

Panama City Tocumen Intl

Mon 2/2

2:27 pm-11:29 pm

1 stop10h 02m

$505

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 12/29

6:46 pm-5:07 pm

2 stops21h 21m

Panama City Tocumen Intl

Mon 3/23

3:41 pm-2:22 pm

2 stops22h 41m

$508

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Sat 2/14

4:41 pm-2:17 pm

1 stop22h 36m

$514

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

3:35 pm-2:45 pm

2 stops22h 10m

Panama City Tocumen Intl

Sat 2/14

4:41 pm-2:17 pm

1 stop22h 36m

$518

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 4/22

6:45 pm-4:12 pm

2 stops21h 27m

Panama City Tocumen Intl

Sun 4/26

10:55 pm-9:52 pm

2 stops22h 57m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $441. If you don’t want to visit Panama in September, then you should wait until July to fly from Des Moines, when ticket prices are also cheap, with an average price of $455.

What is the cheapest day to depart on your flight to Panama?

According to our data, Sunday is the cheapest day to fly to Panama from Des Moines. The lowest ticket price found for a Sunday departure recently was $412. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Panama for around $578.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from Des Moines to Panama when you can find flight prices for as low as $439. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $539 per ticket.

Can stopping save me money on Des Moines to Panama flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama flight.

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Fastest flight time	8h 54m
Direct flights	None

The fastest flight from Des Moines to Panama takes 8h 54m

There are no direct flights from Des Moines to Panama. There are no popular flight routes from Des Moines to Panama.

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to Panama?
Prices for flights from Des Moines Airport to Panama were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Panama?
As of December 2025, there are 2 operators available to choose from for flights from Des Moines Airport to Panama.
How old do you have to be to fly from Des Moines Airport to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.
What documentation or ID do you need to fly to Panama?
The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $420	Free Cancellation	Rating 7.4 9,094 reviews		Search United Airlines flights
Delta	PriceFrom $441	Free Cancellation	Rating 7.9 8,007 reviews		Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama for you.

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Des Moines.

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

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Find better results for your trip to Panama

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Cheap flights from Des Moines to Panama from $198

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 1/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

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Filter for what you want

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Trusted and free

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United Airlines flights from Des Moines to Panama

Our best United Airlines deals on Des Moines to Panama flight tickets

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How to get the cheapest flight ticket from Des Moines to Panama

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $441. If you don’t want to visit Panama in September, then you should wait until July to fly from Des Moines, when ticket prices are also cheap, with an average price of $455.

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on Des Moines to Panama flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama flight.

What is the cheapest airline that flies from Des Moines to Panama?

American Airlines and United Airlines are the most popular carriers operating from Des Moines to Panama

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Fastest flight time

Direct flights

When did momondo last update prices for flights from Des Moines Airport to Panama?

How many operators does momondo search for flights from Des Moines Airport to Panama?

How old do you have to be to fly from Des Moines Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Panama?

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo