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Cheap flights from Des Moines to Panama from $198

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Panama

Cheap round-trip flights

Delta Logo
5:40 am - 12:56 pmDSM-PTY
7h 16m1 stop
Delta Logo
2:21 pm - 10:43 pmPTY-DSM
8h 22m1 stop
$461Delta
Find Deal
Sun, Oct 12 - Tue, Oct 21
American Airlines Logo
6:12 pm - 2:31 pmDSM-PTY
20h 19m2 stops
American Airlines Logo
3:31 pm - 5:39 pmPTY-DSM
26h 08m2 stops
$462American Airlines
Find Deal
Sat, Sep 13 - Sat, Sep 20
American Airlines Logo
4:09 pm - 2:31 pmDSM-PTY
22h 22m2 stops
American Airlines Logo
3:31 pm - 3:16 pmPTY-DSM
23h 45m2 stops
$465American Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
Delta Logo
6:39 pm - 12:56 pmDSM-PTY
18h 17m1 stop
Delta Logo
2:21 pm - 9:34 amPTY-DSM
19h 13m2 stops
$466Delta
Find Deal
Sun, Oct 12 - Fri, Oct 17
American Airlines Logo
7:17 pm - 2:31 pmDSM-PTY
19h 14m2 stops
American Airlines Logo
3:31 pm - 3:20 pmPTY-DSM
23h 49m2 stops
$469American Airlines
Find Deal
Sun, Sep 14 - Sun, Sep 21
Delta Logo
5:14 pm - 12:56 pmDSM-PTY
19h 42m1 stop
Delta Logo
2:21 pm - 10:43 pmPTY-DSM
8h 22m1 stop
$470Delta
Find Deal
Sat, Oct 11 - Mon, Oct 20
American Airlines Logo
2:21 pm - 2:31 pmDSM-PTY
24h 10m2 stops
American Airlines Logo
3:31 pm - 3:24 pmPTY-DSM
23h 53m2 stops
$472American Airlines
Find Deal
Sun, Sep 14 - Sun, Sep 21
United Airlines Logo
6:36 pm - 6:37 pmDSM-PTY
24h 01m2 stops
United Airlines Logo
3:30 pm - 2:13 pmPTY-DSM
22h 43m1 stop
$475United Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
Delta Logo
12:30 pm - 12:56 pmDSM-PTY
24h 26m2 stops
Delta Logo
2:21 pm - 9:20 amPTY-DSM
18h 59m2 stops
$481Delta
Find Deal
Sat, Oct 11 - Thu, Oct 23
United Airlines Logo
6:15 am - 6:37 pmDSM-PTY
12h 22m1 stop
United Airlines Logo
10:00 am - 10:28 pmPTY-DSM
12h 28m1 stop
$506United Airlines
Find Deal
Mon, Oct 13 - Sat, Oct 18

United Airlines flights from Des Moines to Panama

Our best United Airlines deals on Des Moines to Panama flight tickets
United Airlines
Oct 13
DSM6:36 pmDes Moines
24h 01m
2 stops
PTY6:37 pmPanama City Tocumen Intl
Oct 20
PTY3:30 pmPanama City Tocumen Intl
22h 43m
1 stop
DSM2:13 pmDes Moines
$475
Find similar
United Airlines
Oct 13
DSM6:15 amDes Moines
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 18
PTY10:00 amPanama City Tocumen Intl
12h 28m
1 stop
DSM10:28 pmDes Moines
$506
Find similar
United Airlines
Oct 16
DSM6:30 amDes Moines
12h 07m
2 stops
PTY6:37 pmPanama City Tocumen Intl
Oct 18
PTY3:30 pmPanama City Tocumen Intl
19h 02m
2 stops
DSM10:32 amDes Moines
$511
Find similar

American Airlines flights from Des Moines to Panama

Our best American Airlines deals on Des Moines to Panama flight tickets
American Airlines
Sep 13
DSM6:12 pmDes Moines
20h 19m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 20
PTY3:31 pmPanama City Tocumen Intl
26h 08m
2 stops
DSM5:39 pmDes Moines
$462
Find similar
American Airlines
Sep 12
DSM4:09 pmDes Moines
22h 22m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 19
PTY3:31 pmPanama City Tocumen Intl
23h 45m
2 stops
DSM3:16 pmDes Moines
$465
Find similar
American Airlines
Sep 14
DSM7:17 pmDes Moines
19h 14m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 21
PTY3:31 pmPanama City Tocumen Intl
23h 49m
2 stops
DSM3:20 pmDes Moines
$469
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

5:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

Tue 10/21

2:21 pm-10:43 pm

1 stop8h 22m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 9/13

6:12 pm-2:31 pm

2 stops20h 19m

Panama City Tocumen Intl

Sat 9/20

3:31 pm-5:39 pm

2 stops26h 08m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 9/12

4:09 pm-2:31 pm

2 stops22h 22m

Panama City Tocumen Intl

Fri 9/19

3:31 pm-3:16 pm

2 stops23h 45m

$465

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:39 pm-12:56 pm

1 stop18h 17m

Panama City Tocumen Intl

Fri 10/17

2:21 pm-9:34 am

2 stops19h 13m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 9/14

7:17 pm-2:31 pm

2 stops19h 14m

Panama City Tocumen Intl

Sun 9/21

3:31 pm-3:20 pm

2 stops23h 49m

$469

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 10/11

5:14 pm-12:56 pm

1 stop19h 42m

Panama City Tocumen Intl

Mon 10/20

2:21 pm-10:43 pm

1 stop8h 22m

$470

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 9/14

2:21 pm-2:31 pm

2 stops24h 10m

Panama City Tocumen Intl

Sun 9/21

3:31 pm-3:24 pm

2 stops23h 53m

$472

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/13

6:36 pm-6:37 pm

2 stops24h 01m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-2:13 pm

1 stop22h 43m

$475

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 10/11

12:30 pm-12:56 pm

2 stops24h 26m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-9:20 am

2 stops18h 59m

$481

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/13

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Sat 10/18

10:00 am-10:28 pm

1 stop12h 28m

$506

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Des Moines to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $395. If you don’t want to visit Panama in September, then you should wait until December to fly from Des Moines, when ticket prices are also cheap, with an average price of $408.

What is the cheapest day to depart on your flight to Panama?

According to our data, Sunday is the cheapest day to fly to Panama from Des Moines. The lowest ticket price found for a Sunday departure recently was $412. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Panama for around $578.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from Des Moines to Panama when you can find flight prices for as low as $439. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $539 per ticket.

Can stopping save me money on Des Moines to Panama flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama flight.

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Best Price Found

$198

Fastest flight time

7h 11m

Direct flights

None

Airports in Panama

1 airport
The best one-way flight to Panama from Des Moines in the past 72 hours is $198. The best round-trip flight deal from Des Moines to Panama found on momondo in the last 72 hours is $461.
The fastest flight from Des Moines to Panama takes 7h 11m
There are no direct flights from Des Moines to Panama. Popular non-direct route for this connection is Des Moines Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama: Panama City Tocumen Intl (PTY)
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  • When did momondo last update prices for flights from Des Moines Airport to Panama?

    Prices for flights from Des Moines Airport to Panama were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama?

  • How old do you have to be to fly from Des Moines Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $349Free CancellationRating
8.0
7,981 reviews
Search Delta flights
United AirlinesPriceFrom $379Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
American AirlinesPriceFrom $445Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama for you.

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Des Moines.

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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