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Cheap flights from Des Moines to Panama from $330

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:45 pm - 8:50 am-
14h 05m
Multiple Airlines Logo
9:45 am - 10:26 am-
24h 41m
$665Multiple Airlines
Sun, Oct 25 - Thu, Oct 29
Multiple Airlines Logo
3:22 pm - 9:15 am-
17h 53m
Multiple Airlines Logo
5:30 am - 10:30 pm-
17h 00m
$683Multiple Airlines
Wed, Sep 16 - Wed, Sep 23
Multiple Airlines Logo
3:22 pm - 9:15 am-
17h 53m
Multiple Airlines Logo
5:30 am - 10:30 pm-
17h 00m
$683Multiple Airlines
Tue, Sep 15 - Tue, Sep 22
Multiple Airlines Logo
3:22 pm - 9:15 am-
17h 53m
Multiple Airlines Logo
5:30 am - 10:30 pm-
17h 00m
$684Multiple Airlines
Tue, Sep 15 - Tue, Sep 22
United Airlines Logo
6:45 pm - 7:02 pm-
24h 17m
United Airlines Logo
7:55 am - 10:30 pm-
14h 35m
$697United Airlines
Sun, Oct 25 - Thu, Oct 29
American Airlines Logo
9:27 am - 2:16 pm-
27h 49m
American Airlines Logo
3:15 pm - 11:49 pm-
9h 34m
$702American Airlines
Wed, Nov 18 - Thu, Nov 26
American Airlines Logo
3:31 pm - 2:16 pm-
21h 45m
American Airlines Logo
3:15 pm - 10:57 am-
20h 42m
$702American Airlines
Wed, Nov 18 - Thu, Nov 26
American Airlines Logo
5:56 pm - 12:16 pm-
18h 20m
American Airlines Logo
1:16 pm - 8:39 am-
19h 23m
$707American Airlines
Thu, Sep 17 - Thu, Sep 24
American Airlines Logo
5:56 pm - 12:16 pm-
18h 20m
American Airlines Logo
1:16 pm - 8:39 am-
19h 23m
$708American Airlines
Thu, Sep 17 - Thu, Sep 24
United Airlines Logo
6:15 am - 2:14 pm-
7h 59m
United Airlines Logo
10:00 am - 10:30 pm-
12h 30m
$713United Airlines
Wed, Sep 16 - Wed, Sep 23

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Delta flights from Des Moines to Panama

Our best Delta deals on Des Moines to Panama flight tickets
Delta
Oct 25
DSM5:35 amDes Moines
7h 24m
1 stop
PTY12:59 pmPanama City Tocumen Intl
Oct 29
PTY2:24 pmPanama City Tocumen Intl
8h 09m
1 stop
DSM10:33 pmDes Moines
$723
Delta
Sep 15
DSM5:45 amDes Moines
7h 13m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 22
PTY2:23 pmPanama City Tocumen Intl
8h 03m
1 stop
DSM10:26 pmDes Moines
$733
Delta
Sep 19
DSM5:45 amDes Moines
7h 13m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 26
PTY2:23 pmPanama City Tocumen Intl
8h 03m
1 stop
DSM10:26 pmDes Moines
$803

American Airlines flights from Des Moines to Panama

Our best American Airlines deals on Des Moines to Panama flight tickets
American Airlines
Nov 18
DSM9:27 amDes Moines
27h 49m
2 stops
PTY2:16 pmPanama City Tocumen Intl
Nov 26
PTY3:15 pmPanama City Tocumen Intl
9h 34m
1 stop
DSM11:49 pmDes Moines
$702
American Airlines
Sep 17
DSM5:56 pmDes Moines
18h 20m
2 stops
PTY12:16 pmPanama City Tocumen Intl
Sep 24
PTY1:16 pmPanama City Tocumen Intl
19h 23m
2 stops
DSM8:39 amDes Moines
$707
American Airlines
Sep 17
DSM5:56 pmDes Moines
18h 20m
2 stops
PTY12:16 pmPanama City Tocumen Intl
Sep 24
PTY1:16 pmPanama City Tocumen Intl
19h 23m
2 stops
DSM8:39 amDes Moines
$708

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/25

6:45 pm-8:50 am

2 stops14h 05m

Panama City Tocumen Intl

Thu 10/29

9:45 am-10:26 am

2 stops24h 41m

$665

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 9/16

3:22 pm-9:15 am

2 stops17h 53m

Panama City Tocumen Intl

Wed 9/23

5:30 am-10:30 pm

2 stops17h 00m

$683

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/15

3:22 pm-9:15 am

2 stops17h 53m

Panama City Tocumen Intl

Tue 9/22

5:30 am-10:30 pm

2 stops17h 00m

$683

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/15

3:22 pm-9:15 am

2 stops17h 53m

Panama City Tocumen Intl

Tue 9/22

5:30 am-10:30 pm

2 stops17h 00m

$684

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/25

6:45 pm-7:02 pm

2 stops24h 17m

Panama City Tocumen Intl

Thu 10/29

7:55 am-10:30 pm

1 stop14h 35m

$697

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/18

9:27 am-2:16 pm

2 stops27h 49m

Panama City Tocumen Intl

Thu 11/26

3:15 pm-11:49 pm

1 stop9h 34m

$702

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/18

3:31 pm-2:16 pm

2 stops21h 45m

Panama City Tocumen Intl

Thu 11/26

3:15 pm-10:57 am

2 stops20h 42m

$702

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 9/17

5:56 pm-12:16 pm

2 stops18h 20m

Panama City Tocumen Intl

Thu 9/24

1:16 pm-8:39 am

2 stops19h 23m

$707

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 9/17

5:56 pm-12:16 pm

2 stops18h 20m

Panama City Tocumen Intl

Thu 9/24

1:16 pm-8:39 am

2 stops19h 23m

$708
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 9/16

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 9/23

10:00 am-10:30 pm

1 stop12h 30m

$713

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Des Moines to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of May is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $461. If you don’t want to visit Panama in May, then you should wait until February to fly from Des Moines, when ticket prices are also cheap, with an average price of $461.

Can stopping save me money on Des Moines to Panama flights?

You could potentially save up to 21% on your flight if you consider stops on a Des Moines to Panama flight.

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Fastest flight time

10h 37m

Direct flights

None
The fastest flight from Des Moines to Panama takes 10h 37m
There are no direct flights from Des Moines to Panama. There are no popular flight routes from Des Moines to Panama.
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Frequently asked questions about flying from Des Moines to Panama

  • When did momondo last update prices for flights from Des Moines Airport to Panama?

    Prices for flights from Des Moines Airport to Panama were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama?

  • How old do you have to be to fly from Des Moines Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $461Free CancellationRating
7.4
10,058 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama for you.

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Des Moines.

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Fri 9/4
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