What is the cheapest airline that flies from Des Moines to Panama?

United Airlines and WestJet are the most popular carriers operating from Des Moines to Panama

When did momondo last update prices for flights from Des Moines Airport to Panama?

Prices for flights from Des Moines Airport to Panama were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Panama?

As of November 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Panama.

How old do you have to be to fly from Des Moines Airport to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.

What documentation or ID do you need to fly to Panama?

The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$306 Cheap Flights from Des Moines to Panama in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:15 pm - 2:14 pmDSM Des Moines-PTY Panama City Tocumen Intl

22h 59m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:00 am - 10:30 pmPTY Panama City Tocumen Intl-DSM Des Moines

12h 30m1 stop Houston George Bush Intcntl

$672United Airlines

Sun, Apr 18 - Wed, Apr 21

3:15 pm - 2:14 pmDSM Des Moines-PTY Panama City Tocumen Intl

22h 59m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:55 pm - 2:11 pmPTY Panama City Tocumen Intl-DSM Des Moines

15h 16m2 stops Newark Chicago O'Hare Intl

$672United Airlines

Sun, Apr 18 - Wed, Apr 21

3:31 pm - 1:26 pmDSM Des Moines-PTY Panama City Tocumen Intl

20h 55m2 stops Dallas/Fort Worth Miami

4:55 pm - 9:14 amPTY Panama City Tocumen Intl-DSM Des Moines

17h 19m2 stops Miami Dallas/Fort Worth

$706American Airlines

Fri, Jan 22 - Thu, Jan 28

2:39 pm - 1:26 pmDSM Des Moines-PTY Panama City Tocumen Intl

21h 47m2 stops Chicago O'Hare Intl Miami

2:26 pm - 12:26 amPTY Panama City Tocumen Intl-DSM Des Moines

11h 00m2 stops Miami Chicago O'Hare Intl

$745American Airlines

Wed, Jan 6 - Wed, Jan 13

2:39 pm - 1:26 pmDSM Des Moines-PTY Panama City Tocumen Intl

21h 47m2 stops Chicago O'Hare Intl Miami

2:26 pm - 10:59 pmPTY Panama City Tocumen Intl-DSM Des Moines

9h 33m1 stop Miami

$780American Airlines

Wed, Jan 6 - Wed, Jan 13

3:31 pm - 2:13 pmDSM Des Moines-PTY Panama City Tocumen Intl

21h 42m2 stops Dallas/Fort Worth Miami

2:26 pm - 2:31 pmPTY Panama City Tocumen Intl-DSM Des Moines

25h 05m2 stops Miami Dallas/Fort Worth

$808American Airlines

Tue, Dec 8 - Tue, Jan 12

3:31 pm - 2:13 pmDSM Des Moines-PTY Panama City Tocumen Intl

21h 42m2 stops Dallas/Fort Worth Miami

3:34 pm - 10:48 amPTY Panama City Tocumen Intl-DSM Des Moines

20h 14m2 stops Miami Charlotte Douglas

$830American Airlines

Fri, Nov 13 - Sat, Nov 21

5:20 am - 2:03 pmDSM Des Moines-PTY Panama City Tocumen Intl

7h 43m1 stop Atlanta Hartsfield-Jackson

8:00 am - 4:38 pmPTY Panama City Tocumen Intl-DSM Des Moines

9h 38m1 stop Atlanta Hartsfield-Jackson

$871Delta

Tue, Dec 8 - Fri, Jan 8

5:20 am - 2:03 pmDSM Des Moines-PTY Panama City Tocumen Intl

7h 43m1 stop Atlanta Hartsfield-Jackson

8:00 am - 9:19 pmPTY Panama City Tocumen Intl-DSM Des Moines

14h 19m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul

$876Delta

Tue, Dec 8 - Fri, Jan 8

3:31 pm - 2:13 pmDSM Des Moines-PTY Panama City Tocumen Intl

21h 42m2 stops Dallas/Fort Worth Miami

4:21 pm - 9:54 amPTY Panama City Tocumen Intl-DSM Des Moines

18h 33m2 stops Miami Dallas/Fort Worth

$908American Airlines

Tue, Dec 8 - Fri, Jan 8

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United Airlines flights from Des Moines to Panama

Our best United Airlines deals on Des Moines to Panama flight tickets

United Airlines

Apr 18

DSM3:15 pmDes Moines

22h 59m

2 stops

PTY2:14 pmPanama City Tocumen Intl

Apr 21

PTY10:00 amPanama City Tocumen Intl

12h 30m

1 stop

DSM10:30 pmDes Moines

$672

United Airlines

Apr 18

DSM3:00 pmDes Moines

27h 37m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Apr 21

PTY10:00 amPanama City Tocumen Intl

12h 30m

1 stop

DSM10:30 pmDes Moines

$679

United Airlines

Jan 22

DSM8:00 amDes Moines

10h 38m

1 stop

PTY7:38 pmPanama City Tocumen Intl

Jan 28

PTY11:35 amPanama City Tocumen Intl

11h 55m

1 stop

DSM10:30 pmDes Moines

$701

Delta flights from Des Moines to Panama

Our best Delta deals on Des Moines to Panama flight tickets

Delta

Dec 8

DSM5:20 amDes Moines

7h 43m

1 stop

PTY2:03 pmPanama City Tocumen Intl

Jan 8

PTY8:00 amPanama City Tocumen Intl

9h 38m

1 stop

DSM4:38 pmDes Moines

$871

Delta

Dec 8

DSM5:20 amDes Moines

7h 43m

1 stop

PTY2:03 pmPanama City Tocumen Intl

Jan 8

PTY8:00 amPanama City Tocumen Intl

14h 19m

2 stops

DSM9:19 pmDes Moines

$876

Delta

Nov 19

DSM5:30 amDes Moines

7h 32m

1 stop

PTY2:02 pmPanama City Tocumen Intl

Nov 22

PTY3:29 pmPanama City Tocumen Intl

8h 06m

1 stop

DSM10:35 pmDes Moines

$916

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Sun 4/18

3:15 pm-2:14 pm

2 stops22h 59m

Panama City Tocumen Intl

Wed 4/21

10:00 am-10:30 pm

1 stop12h 30m

$672

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Sun 4/18

3:15 pm-2:14 pm

2 stops22h 59m

Panama City Tocumen Intl

Wed 4/21

10:55 pm-2:11 pm

2 stops15h 16m

$672

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Fri 1/22

3:31 pm-1:26 pm

2 stops20h 55m

Panama City Tocumen Intl

Thu 1/28

4:55 pm-9:14 am

2 stops17h 19m

$706

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Wed 1/6

2:39 pm-1:26 pm

2 stops21h 47m

Panama City Tocumen Intl

Wed 1/13

2:26 pm-12:26 am

2 stops11h 00m

$745

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Wed 1/6

2:39 pm-1:26 pm

2 stops21h 47m

Panama City Tocumen Intl

Wed 1/13

2:26 pm-10:59 pm

1 stop9h 33m

$780

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 12/8

3:31 pm-2:13 pm

2 stops21h 42m

Panama City Tocumen Intl

Tue 1/12

2:26 pm-2:31 pm

2 stops25h 05m

$808

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Fri 11/13

3:31 pm-2:13 pm

2 stops21h 42m

Panama City Tocumen Intl

Sat 11/21

3:34 pm-10:48 am

2 stops20h 14m

$830

Quickest round-trip

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 12/8

5:20 am-2:03 pm

1 stop7h 43m

Panama City Tocumen Intl

Fri 1/8

8:00 am-4:38 pm

1 stop9h 38m

$871

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 12/8

5:20 am-2:03 pm

1 stop7h 43m

Panama City Tocumen Intl

Fri 1/8

8:00 am-9:19 pm

2 stops14h 19m

$876

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 12/8

3:31 pm-2:13 pm

2 stops21h 42m

Panama City Tocumen Intl

Fri 1/8

4:21 pm-9:54 am

2 stops18h 33m

$908

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $0. If you don’t want to visit Panama in August, then you should wait until May to fly from Des Moines, when ticket prices are also cheap, with an average price of $0.

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Best Price Found	$306
Fastest flight time	10h 38m
Direct flights	None

The best one-way flight to Panama from Des Moines in the past 72 hours is $306. The best round-trip flight deal from Des Moines to Panama found on momondo in the last 72 hours is $672.

The fastest flight from Des Moines to Panama takes 10h 38m

There are no direct flights from Des Moines to Panama. There are no popular flight routes from Des Moines to Panama.

Search flight deals

Frequently asked questions about flying from Des Moines to Panama

When did momondo last update prices for flights from Des Moines Airport to Panama?
Prices for flights from Des Moines Airport to Panama were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Panama?
As of November 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Panama.
How old do you have to be to fly from Des Moines Airport to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.
What documentation or ID do you need to fly to Panama?
The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $461	Free Cancellation	Rating 7.3 10,460 reviews		Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama for you.

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Des Moines.

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cheap flights from Des Moines to Panama from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Des Moines to Panama

Our best United Airlines deals on Des Moines to Panama flight tickets

Delta flights from Des Moines to Panama

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How to get the cheapest flight ticket from Des Moines to Panama

What is the cheapest month to fly to Panama?

What is the cheapest airline that flies from Des Moines to Panama?

Cheap Des Moines to Panama flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Panama

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Des Moines flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

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Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

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Explore popular destinations other users love

According to popular flight searches on momondo this year