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Cheap flights from Des Moines to Panama from $285

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama departing on 6/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:30 pm - 6:37 pm
DSM
-
PTY
22h 07m
2 stops
United Airlines Logo
3:30 pm - 2:11 pm
PTY
-
DSM
22h 41m
2 stops
$632United Airlines
Sun, Sep 20 - Sat, Sep 26
Delta Logo
5:27 am - 12:50 pm
DSM
-
PTY
7h 23m
1 stop
Delta Logo
2:24 pm - 10:31 pm
PTY
-
DSM
8h 07m
1 stop
$633Delta
Tue, Jun 2 - Tue, Jun 9
United Airlines Logo
6:50 pm - 7:31 pm
DSM
-
PTY
24h 41m
2 stops
United Airlines Logo
7:55 am - 10:40 pm
PTY
-
DSM
14h 45m
1 stop
$637United Airlines
Tue, Jun 2 - Tue, Jun 9
United Airlines Logo
6:15 am - 2:14 pm
DSM
-
PTY
7h 59m
1 stop
United Airlines Logo
10:00 am - 10:23 pm
PTY
-
DSM
12h 23m
1 stop
$670United Airlines
Sun, Sep 20 - Sat, Sep 26
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
3:30 pm - 6:09 pm
PTY
-
DSM
26h 39m
2 stops
$672United Airlines
Tue, Jun 16 - Tue, Jun 23
Delta Logo
5:35 am - 1:09 pm
DSM
-
PTY
7h 34m
1 stop
Delta Logo
2:24 pm - 10:31 pm
PTY
-
DSM
8h 07m
1 stop
$721Delta
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
4:48 pm - 12:13 pm
DSM
-
PTY
19h 25m
2 stops
American Airlines Logo
1:15 pm - 8:32 am
PTY
-
DSM
19h 17m
2 stops
$732American Airlines
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
1:37 pm - 12:13 pm
DSM
-
PTY
22h 36m
2 stops
American Airlines Logo
1:15 pm - 12:52 pm
PTY
-
DSM
23h 37m
2 stops
$734American Airlines
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
1:33 pm - 12:13 pm
DSM
-
PTY
22h 40m
2 stops
American Airlines Logo
1:15 pm - 9:11 am
PTY
-
DSM
19h 56m
2 stops
$739American Airlines
Mon, Jun 15 - Mon, Jun 22
United Airlines Logo
11:26 am - 2:14 pm
DSM
-
PTY
26h 48m
2 stops
United Airlines Logo
3:30 pm - 2:10 pm
PTY
-
DSM
22h 40m
1 stop
$758United Airlines
Thu, Jun 18 - Thu, Jun 25

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Delta flights from Des Moines to Panama

Our best Delta deals on Des Moines to Panama flight tickets
Delta
Jun 2
DSM5:27 amDes Moines
7h 23m
1 stop
PTY12:50 pmPanama City Tocumen Intl
Jun 9
PTY2:24 pmPanama City Tocumen Intl
8h 07m
1 stop
DSM10:31 pmDes Moines
$633
Delta
Jun 17
DSM5:35 amDes Moines
7h 34m
1 stop
PTY1:09 pmPanama City Tocumen Intl
Jun 24
PTY2:24 pmPanama City Tocumen Intl
8h 07m
1 stop
DSM10:31 pmDes Moines
$721
Delta
Jul 1
DSM5:35 amDes Moines
7h 34m
1 stop
PTY1:09 pmPanama City Tocumen Intl
Jul 7
PTY2:24 pmPanama City Tocumen Intl
8h 05m
1 stop
DSM10:29 pmDes Moines
$861

American Airlines flights from Des Moines to Panama

Our best American Airlines deals on Des Moines to Panama flight tickets
American Airlines
Jun 17
DSM4:48 pmDes Moines
19h 25m
2 stops
PTY12:13 pmPanama City Tocumen Intl
Jun 24
PTY1:15 pmPanama City Tocumen Intl
19h 17m
2 stops
DSM8:32 amDes Moines
$732
American Airlines
Jun 17
DSM1:37 pmDes Moines
22h 36m
2 stops
PTY12:13 pmPanama City Tocumen Intl
Jun 24
PTY1:15 pmPanama City Tocumen Intl
23h 37m
2 stops
DSM12:52 pmDes Moines
$734
American Airlines
Jun 15
DSM1:33 pmDes Moines
22h 40m
2 stops
PTY12:13 pmPanama City Tocumen Intl
Jun 22
PTY1:15 pmPanama City Tocumen Intl
19h 56m
2 stops
DSM9:11 amDes Moines
$739

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 9/20

8:30 pm-6:37 pm

2 stops22h 07m

Panama City Tocumen Intl

Sat 9/26

3:30 pm-2:11 pm

2 stops22h 41m

$632
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 6/2

5:27 am-12:50 pm

1 stop7h 23m

Panama City Tocumen Intl

Tue 6/9

2:24 pm-10:31 pm

1 stop8h 07m

$633

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 6/2

6:50 pm-7:31 pm

2 stops24h 41m

Panama City Tocumen Intl

Tue 6/9

7:55 am-10:40 pm

1 stop14h 45m

$637

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 9/20

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Sat 9/26

10:00 am-10:23 pm

1 stop12h 23m

$670

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 6/16

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/23

3:30 pm-6:09 pm

2 stops26h 39m

$672

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 6/17

5:35 am-1:09 pm

1 stop7h 34m

Panama City Tocumen Intl

Wed 6/24

2:24 pm-10:31 pm

1 stop8h 07m

$721

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 6/17

4:48 pm-12:13 pm

2 stops19h 25m

Panama City Tocumen Intl

Wed 6/24

1:15 pm-8:32 am

2 stops19h 17m

$732

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 6/17

1:37 pm-12:13 pm

2 stops22h 36m

Panama City Tocumen Intl

Wed 6/24

1:15 pm-12:52 pm

2 stops23h 37m

$734

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 6/15

1:33 pm-12:13 pm

2 stops22h 40m

Panama City Tocumen Intl

Mon 6/22

1:15 pm-9:11 am

2 stops19h 56m

$739

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 6/18

11:26 am-2:14 pm

2 stops26h 48m

Panama City Tocumen Intl

Thu 6/25

3:30 pm-2:10 pm

1 stop22h 40m

$758

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Des Moines to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Des Moines, with most prices found around $441. If you don’t want to visit Panama in August, then you should wait until January to fly from Des Moines, when ticket prices are also cheap, with an average price of $445.

Can stopping save me money on Des Moines to Panama flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama flight.

Cheap Des Moines to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama

Fastest flight time

7h 23m

Direct flights

None
The fastest flight from Des Moines to Panama takes 7h 23m
There are no direct flights from Des Moines to Panama. There are no popular flight routes from Des Moines to Panama.
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Frequently asked questions about flying from Des Moines to Panama

  • When did momondo last update prices for flights from Des Moines Airport to Panama?

    Prices for flights from Des Moines Airport to Panama were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama?

  • How old do you have to be to fly from Des Moines Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Panama

Compare and see reviews for airlines that fly from Des Moines to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $441Free CancellationRating
7.9
8,459 reviews
Search Delta flights
United AirlinesPriceFrom $461Free CancellationRating
7.4
9,683 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama for you.

Can I find flights from Des Moines to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Des Moines.

I’m not ready to book a flight from Des Moines to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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