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Cheap flights from Des Moines to Guayaquil from $353

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guayaquil departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:49 pm - 9:39 pm
DSM
-
GYE
25h 50m
2 stops
American Airlines Logo
6:00 am - 9:37 pm
GYE
-
DSM
15h 37m
2 stops
$701American Airlines
Wed, Sep 2 - Sun, Sep 20
Delta Logo
2:15 pm - 1:40 am
DSM
-
GYE
34h 25m
2 stops
Delta Logo
5:00 pm - 4:04 pm
GYE
-
DSM
24h 04m
1 stop
$707Delta
Thu, Nov 12 - Sun, Dec 13
Delta Logo
2:15 pm - 1:40 am
DSM
-
GYE
34h 25m
2 stops
Delta Logo
5:00 pm - 9:24 am
GYE
-
DSM
17h 24m
2 stops
$734Delta
Tue, Nov 3 - Fri, Dec 4
American Airlines Logo
7:49 pm - 9:39 pm
DSM
-
GYE
25h 50m
2 stops
American Airlines Logo
6:00 am - 11:41 pm
GYE
-
DSM
17h 41m
2 stops
$778American Airlines
Fri, Aug 14 - Mon, Sep 14
Avianca Logo
3:15 pm - 9:15 am
DSM
-
GYE
17h 00m
2 stops
Avianca Logo
10:25 am - 9:17 pm
GYE
-
DSM
35h 52m
2 stops
$800Avianca
Tue, Nov 10 - Fri, Dec 11
Delta Logo
5:30 pm - 8:02 am
DSM
-
GYE
13h 32m
1 stop
Delta Logo
8:00 pm - 10:18 am
GYE
-
DSM
15h 18m
2 stops
$804Delta
Mon, Nov 16 - Wed, Dec 16
Delta Logo
11:04 am - 8:02 am
DSM
-
GYE
19h 58m
2 stops
Delta Logo
5:00 pm - 9:24 am
GYE
-
DSM
17h 24m
2 stops
$809Delta
Sun, Nov 8 - Tue, Dec 8
American Airlines Logo
6:00 am - 10:40 pm
DSM
-
GYE
15h 40m
1 stop
American Airlines Logo
6:00 am - 11:29 pm
GYE
-
DSM
18h 29m
1 stop
$826American Airlines
Tue, Nov 10 - Thu, Dec 10
American Airlines Logo
5:00 am - 10:37 pm
DSM
-
GYE
17h 37m
2 stops
American Airlines Logo
6:00 am - 11:13 pm
GYE
-
DSM
17h 13m
2 stops
$828American Airlines
Mon, Jul 6 - Wed, Sep 30
American Airlines Logo
6:11 pm - 9:39 pm
DSM
-
GYE
27h 28m
2 stops
American Airlines Logo
6:00 am - 12:04 am
GYE
-
DSM
18h 04m
2 stops
$831American Airlines
Sun, Aug 16 - Tue, Sep 15

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Delta flights from Des Moines to Guayaquil

Our best Delta deals on Des Moines to Guayaquil flight tickets
Delta
Nov 12
DSM2:15 pmDes Moines
34h 25m
2 stops
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
Dec 13
GYE5:00 pmGuayaquil Jose Joaquin de Olmedo
24h 04m
1 stop
DSM4:04 pmDes Moines
$707
Delta
Nov 3
DSM2:15 pmDes Moines
34h 25m
2 stops
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
Dec 4
GYE5:00 pmGuayaquil Jose Joaquin de Olmedo
17h 24m
2 stops
DSM9:24 amDes Moines
$734
Delta
Nov 16
DSM5:30 pmDes Moines
13h 32m
1 stop
GYE8:02 amGuayaquil Jose Joaquin de Olmedo
Dec 16
GYE8:00 pmGuayaquil Jose Joaquin de Olmedo
15h 18m
2 stops
DSM10:18 amDes Moines
$804

United Airlines flights from Des Moines to Guayaquil

Our best United Airlines deals on Des Moines to Guayaquil flight tickets
United Airlines
Nov 12
DSM6:21 amDes Moines
16h 19m
3 stops
GYE11:40 pmGuayaquil Jose Joaquin de Olmedo
Dec 12
GYE8:25 amGuayaquil Jose Joaquin de Olmedo
15h 05m
2 stops
DSM10:30 pmDes Moines
$833
United Airlines
Aug 15
DSM3:02 pmDes Moines
50h 29m
2 stops
GYE5:31 pmGuayaquil Jose Joaquin de Olmedo
Sep 16
GYE2:37 pmGuayaquil Jose Joaquin de Olmedo
31h 53m
2 stops
DSM10:30 pmDes Moines
$845
United Airlines
Aug 16
DSM6:15 amDes Moines
11h 16m
2 stops
GYE5:31 pmGuayaquil Jose Joaquin de Olmedo
Sep 14
GYE12:22 pmGuayaquil Jose Joaquin de Olmedo
46h 09m
3 stops
DSM10:31 amDes Moines
$850

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 9/2

7:49 pm-9:39 pm

2 stops25h 50m

Guayaquil Jose Joaquin de Olmedo

Sun 9/20

6:00 am-9:37 pm

2 stops15h 37m

$701

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Thu 11/12

2:15 pm-1:40 am

2 stops34h 25m

Guayaquil Jose Joaquin de Olmedo

Sun 12/13

5:00 pm-4:04 pm

1 stop24h 04m

$707

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 11/3

2:15 pm-1:40 am

2 stops34h 25m

Guayaquil Jose Joaquin de Olmedo

Fri 12/4

5:00 pm-9:24 am

2 stops17h 24m

$734

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Fri 8/14

7:49 pm-9:39 pm

2 stops25h 50m

Guayaquil Jose Joaquin de Olmedo

Mon 9/14

6:00 am-11:41 pm

2 stops17h 41m

$778

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 11/10

3:15 pm-9:15 am

2 stops17h 00m

Guayaquil Jose Joaquin de Olmedo

Fri 12/11

10:25 am-9:17 pm

2 stops35h 52m

$800
Quickest round-trip

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Mon 11/16

5:30 pm-8:02 am

1 stop13h 32m

Guayaquil Jose Joaquin de Olmedo

Wed 12/16

8:00 pm-10:18 am

2 stops15h 18m

$804

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 11/8

11:04 am-8:02 am

2 stops19h 58m

Guayaquil Jose Joaquin de Olmedo

Tue 12/8

5:00 pm-9:24 am

2 stops17h 24m

$809

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 11/10

6:00 am-10:40 pm

1 stop15h 40m

Guayaquil Jose Joaquin de Olmedo

Thu 12/10

6:00 am-11:29 pm

1 stop18h 29m

$826

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Mon 7/6

5:00 am-10:37 pm

2 stops17h 37m

Guayaquil Jose Joaquin de Olmedo

Wed 9/30

6:00 am-11:13 pm

2 stops17h 13m

$828

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 8/16

6:11 pm-9:39 pm

2 stops27h 28m

Guayaquil Jose Joaquin de Olmedo

Tue 9/15

6:00 am-12:04 am

2 stops18h 04m

$831

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Des Moines to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Guayaquil Jose Joaquin de Olmedo?

United Airlines is the most popular carrier operating from Des Moines to Guayaquil Jose Joaquin de Olmedo

When to book flights from Des Moines to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guayaquil (DSM to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guayaquil

Fastest flight time

14h 05m

Direct flights

None
The fastest flight from Des Moines to Guayaquil takes 14h 05m
There are no direct flights from Des Moines to Guayaquil. There are no popular flight routes from Des Moines to Guayaquil.
Search flight deals

Frequently asked questions about flying from Des Moines to Guayaquil

  • How far is Des Moines to Guayaquil Jose Joaquin de Olmedo by plane?

    Des Moines and Guayaquil Jose Joaquin de Olmedo are 3143.1 mi apart from one another. Flights usually cover this in 14h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The travel and health documents required for your trip to Guayaquil Jose Joaquin de Olmedo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guayaquil Jose Joaquin de Olmedo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guayaquil?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Guayaquil from Des Moines.

Can I find flights from Des Moines to Guayaquil with flexible booking policies on momondo?

momondo does allow users to show only those flights to Guayaquil from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Guayaquil?

momondo helps you find the best flight between Des Moines and Guayaquil by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Guayaquil right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Guayaquil flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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