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Cheap flights from Des Moines to Guayaquil from $237

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guayaquil departing on 6/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:22 pm - 1:31 pm
DSM
-
GYE
22h 09m
2 stops
American Airlines Logo
6:01 am - 9:23 pm
GYE
-
DSM
15h 22m
2 stops
$704American Airlines
Mon, Jun 1 - Tue, Jun 30
American Airlines Logo
6:02 am - 10:36 pm
DSM
-
GYE
16h 34m
2 stops
American Airlines Logo
6:01 am - 11:50 pm
GYE
-
DSM
17h 49m
2 stops
$737American Airlines
Thu, Jun 18 - Thu, Jun 25
American Airlines Logo
1:37 pm - 1:31 pm
DSM
-
GYE
23h 54m
2 stops
American Airlines Logo
2:31 pm - 1:03 pm
GYE
-
DSM
22h 32m
2 stops
$747American Airlines
Sat, Jun 20 - Sat, Jun 27
American Airlines Logo
1:37 pm - 1:31 pm
DSM
-
GYE
23h 54m
2 stops
American Airlines Logo
6:01 am - 11:50 pm
GYE
-
DSM
17h 49m
2 stops
$753American Airlines
Fri, Jun 19 - Fri, Jun 26
American Airlines Logo
1:37 pm - 1:31 pm
DSM
-
GYE
23h 54m
2 stops
American Airlines Logo
6:01 am - 11:26 pm
GYE
-
DSM
17h 25m
1 stop
$791American Airlines
Sat, Jun 20 - Sat, Jun 27
American Airlines Logo
7:10 pm - 1:31 pm
DSM
-
GYE
18h 21m
2 stops
American Airlines Logo
2:25 pm - 12:56 pm
GYE
-
DSM
22h 31m
2 stops
$833American Airlines
Sun, May 31 - Fri, Jul 31
American Airlines Logo
5:50 am - 10:37 pm
DSM
-
GYE
16h 47m
1 stop
American Airlines Logo
2:31 pm - 8:32 am
GYE
-
DSM
18h 01m
2 stops
$871American Airlines
Mon, Jun 1 - Tue, Jun 30
American Airlines Logo
7:10 am - 10:36 pm
DSM
-
GYE
15h 26m
2 stops
American Airlines Logo
6:01 am - 10:52 pm
GYE
-
DSM
16h 51m
2 stops
$915American Airlines
Tue, Jun 16 - Tue, Jun 23
American Airlines Logo
6:30 am - 10:36 pm
DSM
-
GYE
16h 06m
2 stops
American Airlines Logo
6:01 am - 10:52 pm
GYE
-
DSM
16h 51m
2 stops
$988American Airlines
Tue, Jun 16 - Tue, Jun 23
American Airlines Logo
6:02 am - 10:36 pm
DSM
-
GYE
16h 34m
2 stops
American Airlines Logo
6:01 am - 8:43 pm
GYE
-
DSM
14h 42m
2 stops
$1,003American Airlines
Sun, Jun 21 - Sun, Jun 28

American Airlines flights from Des Moines to Guayaquil

Our best American Airlines deals on Des Moines to Guayaquil flight tickets
American Airlines
Jun 1
DSM3:22 pmDes Moines
22h 09m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
Jun 30
GYE6:01 amGuayaquil Jose Joaquin de Olmedo
15h 22m
2 stops
DSM9:23 pmDes Moines
$704
American Airlines
Jun 18
DSM6:02 amDes Moines
16h 34m
2 stops
GYE10:36 pmGuayaquil Jose Joaquin de Olmedo
Jun 25
GYE6:01 amGuayaquil Jose Joaquin de Olmedo
17h 49m
2 stops
DSM11:50 pmDes Moines
$737
American Airlines
Jun 20
DSM1:37 pmDes Moines
23h 54m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
Jun 27
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
22h 32m
2 stops
DSM1:03 pmDes Moines
$747

United Airlines flights from Des Moines to Guayaquil

Our best United Airlines deals on Des Moines to Guayaquil flight tickets
United Airlines
May 31
DSM6:00 amDes Moines
41h 36m
3 stops
GYE11:36 pmGuayaquil Jose Joaquin de Olmedo
Jul 31
GYE8:27 amGuayaquil Jose Joaquin de Olmedo
33h 46m
2 stops
DSM6:13 pmDes Moines
$1,589
United Airlines
Jun 1
DSM8:00 amDes Moines
15h 36m
2 stops
GYE11:36 pmGuayaquil Jose Joaquin de Olmedo
Jun 30
GYE8:27 amGuayaquil Jose Joaquin de Olmedo
14h 24m
3 stops
DSM10:51 pmDes Moines
$7,143

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Mon 6/1

3:22 pm-1:31 pm

2 stops22h 09m

Guayaquil Jose Joaquin de Olmedo

Tue 6/30

6:01 am-9:23 pm

2 stops15h 22m

$704

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Thu 6/18

6:02 am-10:36 pm

2 stops16h 34m

Guayaquil Jose Joaquin de Olmedo

Thu 6/25

6:01 am-11:50 pm

2 stops17h 49m

$737

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sat 6/20

1:37 pm-1:31 pm

2 stops23h 54m

Guayaquil Jose Joaquin de Olmedo

Sat 6/27

2:31 pm-1:03 pm

2 stops22h 32m

$747

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Fri 6/19

1:37 pm-1:31 pm

2 stops23h 54m

Guayaquil Jose Joaquin de Olmedo

Fri 6/26

6:01 am-11:50 pm

2 stops17h 49m

$753

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sat 6/20

1:37 pm-1:31 pm

2 stops23h 54m

Guayaquil Jose Joaquin de Olmedo

Sat 6/27

6:01 am-11:26 pm

1 stop17h 25m

$791

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 5/31

7:10 pm-1:31 pm

2 stops18h 21m

Guayaquil Jose Joaquin de Olmedo

Fri 7/31

2:25 pm-12:56 pm

2 stops22h 31m

$833

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Mon 6/1

5:50 am-10:37 pm

1 stop16h 47m

Guayaquil Jose Joaquin de Olmedo

Tue 6/30

2:31 pm-8:32 am

2 stops18h 01m

$871

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 6/16

7:10 am-10:36 pm

2 stops15h 26m

Guayaquil Jose Joaquin de Olmedo

Tue 6/23

6:01 am-10:52 pm

2 stops16h 51m

$915

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 6/16

6:30 am-10:36 pm

2 stops16h 06m

Guayaquil Jose Joaquin de Olmedo

Tue 6/23

6:01 am-10:52 pm

2 stops16h 51m

$988
Quickest round-trip

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 6/21

6:02 am-10:36 pm

2 stops16h 34m

Guayaquil Jose Joaquin de Olmedo

Sun 6/28

6:01 am-8:43 pm

2 stops14h 42m

$1,003

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Des Moines to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Guayaquil Jose Joaquin de Olmedo?

Copa Airlines is the most popular carrier operating from Des Moines to Guayaquil Jose Joaquin de Olmedo

When to book flights from Des Moines to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guayaquil (DSM to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guayaquil

Fastest flight time

14h 42m

Direct flights

None
The fastest flight from Des Moines to Guayaquil takes 14h 42m
There are no direct flights from Des Moines to Guayaquil. There are no popular flight routes from Des Moines to Guayaquil.
Search flight deals

Frequently asked questions about flying from Des Moines to Guayaquil

  • How far is Des Moines to Guayaquil Jose Joaquin de Olmedo by plane?

    Des Moines and Guayaquil Jose Joaquin de Olmedo are 3143.1 mi apart from one another. Flights usually cover this in 14h 42m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The travel and health documents required for your trip to Guayaquil Jose Joaquin de Olmedo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guayaquil Jose Joaquin de Olmedo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guayaquil?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Guayaquil from Des Moines.

Can I find flights from Des Moines to Guayaquil with flexible booking policies on momondo?

momondo does allow users to show only those flights to Guayaquil from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Guayaquil?

momondo helps you find the best flight between Des Moines and Guayaquil by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Guayaquil right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Guayaquil flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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