Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Des Moines to Guayaquil from $353

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guayaquil departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Des Moines to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
6:45 pm - 5:45 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
22h 00m2 stops Chicago O'Hare Intl Bogotá El Dorado
Avianca Logo
6:55 pm - 7:25 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
49h 30m2 stops Bogotá El Dorado Chicago O'Hare Intl
$800Avianca
Tue, Jan 26 - Thu, Jan 28
American Airlines Logo
7:38 pm - 11:55 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
27h 17m2 stops Dallas/Fort Worth Miami
American Airlines Logo
3:30 pm - 1:30 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
23h 00m2 stops Miami Chicago O'Hare Intl
$898American Airlines
Thu, Dec 24 - Thu, Jan 7
American Airlines Logo
7:38 pm - 11:55 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
27h 17m2 stops Dallas/Fort Worth Miami
American Airlines Logo
3:30 pm - 3:45 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
25h 15m2 stops Miami Charlotte Douglas
$927American Airlines
Thu, Dec 24 - Fri, Jan 8
American Airlines Logo
7:38 pm - 11:55 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
27h 17m2 stops Dallas/Fort Worth Miami
American Airlines Logo
7:15 am - 11:29 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
17h 14m1 stop Miami
$1,043American Airlines
Thu, Dec 24 - Fri, Jan 8
British Airways Logo
7:40 pm - 10:10 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
26h 30m2 stops Dallas/Fort Worth Miami
British Airways Logo
6:00 am - 11:12 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
17h 12m2 stops Miami Dallas/Fort Worth
$1,048British Airways
Sun, Sep 27 - Sun, Oct 4
United Airlines Logo
6:00 am - 8:57 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
13h 57m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
United Airlines Logo
8:25 am - 11:01 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
15h 36m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$1,514United Airlines
Thu, Dec 24 - Thu, Jan 7
GOL Logo
5:00 am - 11:55 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
17h 55m1 stop Miami
GOL Logo
7:15 am - 11:29 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
17h 14m1 stop Miami
$1,586GOL
Thu, Dec 24 - Fri, Jan 8
United Airlines Logo
8:00 am - 11:41 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
14h 41m3 stops Chicago O'Hare Intl Atlanta Hartsfield-Jackson Panama City Tocumen Intl
United Airlines Logo
8:25 am - 11:01 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
15h 36m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$7,483United Airlines
Thu, Dec 24 - Thu, Jan 7
United Airlines Logo
8:00 am - 11:41 pmDSM  Des Moines-GYE Guayaquil Jose Joaquin de Olmedo
14h 41m3 stops Chicago O'Hare Intl Atlanta Hartsfield-Jackson Panama City Tocumen Intl
United Airlines Logo
8:25 am - 11:01 pmGYE  Guayaquil Jose Joaquin de Olmedo-DSM Des Moines
15h 36m3 stops Panama City Tocumen Intl Miami Chicago O'Hare Intl
$7,774United Airlines
Thu, Dec 24 - Fri, Jan 8

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Des Moines to Guayaquil

Our best American Airlines deals on Des Moines to Guayaquil flight tickets
American Airlines
Dec 24
DSM7:38 pmDes Moines
27h 17m
2 stops
GYE11:55 pmGuayaquil Jose Joaquin de Olmedo
Jan 7
GYE3:30 pmGuayaquil Jose Joaquin de Olmedo
23h 00m
2 stops
DSM1:30 pmDes Moines
$898
American Airlines
Dec 24
DSM7:38 pmDes Moines
27h 17m
2 stops
GYE11:55 pmGuayaquil Jose Joaquin de Olmedo
Jan 8
GYE3:30 pmGuayaquil Jose Joaquin de Olmedo
25h 15m
2 stops
DSM3:45 pmDes Moines
$927
American Airlines
Dec 24
DSM7:38 pmDes Moines
27h 17m
2 stops
GYE11:55 pmGuayaquil Jose Joaquin de Olmedo
Jan 8
GYE7:15 amGuayaquil Jose Joaquin de Olmedo
17h 14m
1 stop
DSM11:29 pmDes Moines
$1,043

United Airlines flights from Des Moines to Guayaquil

Our best United Airlines deals on Des Moines to Guayaquil flight tickets
United Airlines
Dec 24
DSM6:00 amDes Moines
13h 57m
2 stops
GYE8:57 pmGuayaquil Jose Joaquin de Olmedo
Jan 7
GYE8:25 amGuayaquil Jose Joaquin de Olmedo
15h 36m
3 stops
DSM11:01 pmDes Moines
$1,514
United Airlines
Dec 24
DSM8:00 amDes Moines
14h 41m
3 stops
GYE11:41 pmGuayaquil Jose Joaquin de Olmedo
Jan 7
GYE8:25 amGuayaquil Jose Joaquin de Olmedo
15h 36m
3 stops
DSM11:01 pmDes Moines
$7,483
United Airlines
Dec 24
DSM8:00 amDes Moines
14h 41m
3 stops
GYE11:41 pmGuayaquil Jose Joaquin de Olmedo
Jan 8
GYE8:25 amGuayaquil Jose Joaquin de Olmedo
15h 36m
3 stops
DSM11:01 pmDes Moines
$7,774

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Tue 1/26

6:45 pm-5:45 pm

2 stops22h 00m

Guayaquil Jose Joaquin de Olmedo

Thu 1/28

6:55 pm-7:25 pm

2 stops49h 30m

$800

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

7:38 pm-11:55 pm

2 stops27h 17m

Guayaquil Jose Joaquin de Olmedo

Thu 1/7

3:30 pm-1:30 pm

2 stops23h 00m

$898

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

7:38 pm-11:55 pm

2 stops27h 17m

Guayaquil Jose Joaquin de Olmedo

Fri 1/8

3:30 pm-3:45 pm

2 stops25h 15m

$927

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

7:38 pm-11:55 pm

2 stops27h 17m

Guayaquil Jose Joaquin de Olmedo

Fri 1/8

7:15 am-11:29 pm

1 stop17h 14m

$1,043

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Sun 9/27

7:40 pm-10:10 pm

2 stops26h 30m

Guayaquil Jose Joaquin de Olmedo

Sun 10/4

6:00 am-11:12 pm

2 stops17h 12m

$1,048
Quickest round-trip

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

6:00 am-8:57 pm

2 stops13h 57m

Guayaquil Jose Joaquin de Olmedo

Thu 1/7

8:25 am-11:01 pm

3 stops15h 36m

$1,514

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

5:00 am-11:55 pm

1 stop17h 55m

Guayaquil Jose Joaquin de Olmedo

Fri 1/8

7:15 am-11:29 pm

1 stop17h 14m

$1,586

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

8:00 am-11:41 pm

3 stops14h 41m

Guayaquil Jose Joaquin de Olmedo

Thu 1/7

8:25 am-11:01 pm

3 stops15h 36m

$7,483

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Thu 12/24

8:00 am-11:41 pm

3 stops14h 41m

Guayaquil Jose Joaquin de Olmedo

Fri 1/8

8:25 am-11:01 pm

3 stops15h 36m

$7,774
Cheapest one-way
Quickest one-way

Des MoinesGuayaquil

DSM Des Moines - GYE Guayaquil Jose Joaquin de Olmedo

DSMGYE

Des Moines

Wed 10/28

6:45 pm-9:15 am

2 stops14h 30m

$353

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

See travel insights to Guayaquil from

How to get the cheapest flight ticket from Des Moines to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Guayaquil Jose Joaquin de Olmedo?

United Airlines is the most popular carrier operating from Des Moines to Guayaquil Jose Joaquin de Olmedo

When to book flights from Des Moines to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guayaquil (DSM to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guayaquil

Fastest flight time

14h 43m

Direct flights

None
The fastest flight from Des Moines to Guayaquil takes 14h 43m
There are no direct flights from Des Moines to Guayaquil. There are no popular flight routes from Des Moines to Guayaquil.
Search flight deals

Frequently asked questions about flying from Des Moines to Guayaquil

  • How far is Des Moines to Guayaquil Jose Joaquin de Olmedo by plane?

    Des Moines and Guayaquil Jose Joaquin de Olmedo are 3143.1 mi apart from one another. Flights usually cover this in 14h 43m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The travel and health documents required for your trip to Guayaquil Jose Joaquin de Olmedo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guayaquil Jose Joaquin de Olmedo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guayaquil?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Guayaquil from Des Moines.

Can I find flights from Des Moines to Guayaquil with flexible booking policies on momondo?

momondo does allow users to show only those flights to Guayaquil from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Guayaquil?

momondo helps you find the best flight between Des Moines and Guayaquil by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Guayaquil right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Guayaquil flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Guayaquil trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 9/13
Sun 9/20
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Ecuador