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Cheap flights from Des Moines to Guayaquil from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Guayaquil departing on 1/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:09 am - 12:21 am
DSM
-
GYE
36h 12m2 stops
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$403Multiple Airlines
Mon, Feb 9 - Wed, Feb 25
Multiple Airlines Logo
6:14 pm - 12:01 am
DSM
-
GYE
28h 47m2 stops
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$437Multiple Airlines
Sat, Feb 14 - Wed, Feb 25
Multiple Airlines Logo
3:32 pm - 12:01 am
DSM
-
GYE
31h 29m1 stop
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$439Multiple Airlines
Sun, Feb 15 - Wed, Feb 25
Multiple Airlines Logo
3:32 pm - 12:01 am
DSM
-
GYE
31h 29m1 stop
Multiple Airlines Logo
4:40 am - 11:06 pm
GYE
-
DSM
19h 26m2 stops
$452Multiple Airlines
Sun, Feb 15 - Wed, Feb 25
Multiple Airlines Logo
8:38 pm - 12:01 am
DSM
-
GYE
26h 23m2 stops
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$455Multiple Airlines
Fri, Feb 13 - Wed, Feb 25
Multiple Airlines Logo
11:36 am - 12:01 am
DSM
-
GYE
35h 25m2 stops
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$471Multiple Airlines
Wed, Feb 11 - Wed, Feb 25
Multiple Airlines Logo
3:32 pm - 12:01 am
DSM
-
GYE
31h 29m1 stop
Multiple Airlines Logo
12:59 am - 2:18 pm
GYE
-
DSM
38h 19m2 stops
$489Multiple Airlines
Sun, Feb 15 - Tue, Feb 24
Multiple Airlines Logo
3:32 pm - 12:01 am
DSM
-
GYE
31h 29m1 stop
Multiple Airlines Logo
12:59 am - 10:35 am
GYE
-
DSM
34h 36m2 stops
$503Multiple Airlines
Sun, Feb 15 - Mon, Mar 2
Multiple Airlines Logo
6:14 pm - 12:21 am
DSM
-
GYE
29h 07m3 stops
Multiple Airlines Logo
3:35 pm - 10:46 pm
GYE
-
DSM
32h 11m2 stops
$507Multiple Airlines
Wed, Jan 21 - Wed, Jan 28
Multiple Airlines Logo
3:32 pm - 12:01 am
DSM
-
GYE
31h 29m1 stop
Multiple Airlines Logo
12:59 am - 11:06 pm
GYE
-
DSM
23h 07m1 stop
$508Multiple Airlines
Thu, Feb 12 - Wed, Feb 25

Delta flights from Des Moines to Guayaquil

Our best Delta deals on Des Moines to Guayaquil flight tickets
Delta
Feb 9
DSM5:16 pmDes Moines
31h 24m
2 stops
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
Mar 3
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
15h 00m
2 stops
DSM10:40 amDes Moines
$608
Find similar
Delta
Feb 14
DSM5:24 amDes Moines
19h 16m
2 stops
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
Mar 3
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
15h 00m
2 stops
DSM10:40 amDes Moines
$618
Find similar

United Airlines flights from Des Moines to Guayaquil

Our best United Airlines deals on Des Moines to Guayaquil flight tickets
United Airlines
Feb 9
DSM8:10 amDes Moines
14h 32m
2 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
Feb 25
GYE8:34 amGuayaquil Jose Joaquin de Olmedo
14h 46m
2 stops
DSM10:20 pmDes Moines
$611
Find similar
United Airlines
Feb 9
DSM8:10 amDes Moines
14h 32m
2 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
Feb 26
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
26h 57m
2 stops
DSM2:17 pmDes Moines
$620
Find similar
United Airlines
Feb 14
DSM8:08 amDes Moines
14h 34m
2 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
Feb 25
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
32h 45m
2 stops
DSM10:20 pmDes Moines
$621
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Mon 2/9

11:09 am-12:21 am

2 stops36h 12m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$403

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sat 2/14

6:14 pm-12:01 am

2 stops28h 47m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$437

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:01 am

1 stop31h 29m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$439

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:01 am

1 stop31h 29m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

4:40 am-11:06 pm

2 stops19h 26m

$452

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Fri 2/13

8:38 pm-12:01 am

2 stops26h 23m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$455

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 2/11

11:36 am-12:01 am

2 stops35h 25m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$471

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:01 am

1 stop31h 29m

Guayaquil Jose Joaquin de Olmedo

Tue 2/24

12:59 am-2:18 pm

2 stops38h 19m

$489

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:01 am

1 stop31h 29m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-10:35 am

2 stops34h 36m

$503

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 1/21

6:14 pm-12:21 am

3 stops29h 07m

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

3:35 pm-10:46 pm

2 stops32h 11m

$507

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Thu 2/12

3:32 pm-12:01 am

1 stop31h 29m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

12:59 am-11:06 pm

1 stop23h 07m

$508

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Des Moines to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Des Moines to Guayaquil is on a Sunday. Travelers who choose to depart for Guayaquil on a Sunday will often find tickets for as low as $476. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Friday is $925.

What is the cheapest time of day to depart on your flight to Guayaquil?

The cheapest time of day to fly to Guayaquil is in the morning when flights can be purchased for as low as $693. Flights to Guayaquil are more costly in the afternoon, with an average ticket price of $767. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Des Moines to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Guayaquil (DSM to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Guayaquil

Fastest flight time

27h 55m

Direct flights

None
The fastest flight from Des Moines to Guayaquil takes 27h 55m
There are no direct flights from Des Moines to Guayaquil. There are no popular flight routes from Des Moines to Guayaquil.
Search flight deals

  • How far is Des Moines to Guayaquil Jose Joaquin de Olmedo by plane?

    Des Moines and Guayaquil Jose Joaquin de Olmedo are 3143.1 mi apart from one another. Flights usually cover this in 11h 36m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The travel and health documents required for your trip to Guayaquil Jose Joaquin de Olmedo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guayaquil Jose Joaquin de Olmedo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Guayaquil?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Guayaquil from Des Moines.

Can I find flights from Des Moines to Guayaquil with flexible booking policies on momondo?

momondo does allow users to show only those flights to Guayaquil from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Guayaquil?

momondo helps you find the best flight between Des Moines and Guayaquil by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Guayaquil right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Guayaquil flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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