Cheap flights from Des Moines to Houston from $99

The month of October is, on average, the cheapest month to fly to Houston George Bush Intcntl Airport from Des Moines, with most prices found around $262. If you are unable to visit Houston George Bush Intcntl Airport during the month of October, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $284.

The cheapest day to depart from Des Moines to Houston George Bush Intcntl Airport is on a Friday. Travelers who choose to depart for Houston George Bush Intcntl Airport on a Friday will often find tickets for as low as $486. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Houston George Bush Intcntl Airport on Monday is $596.

Our data shows that the cheapest Des Moines to Houston George Bush Intcntl Airport flights are usually those with departure times in the afternoon. Our users have found flights to Houston George Bush Intcntl Airport in the afternoon for as low as $447. Try not to purchase tickets in the morning because they tend to be around $563. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Houston George Bush Intcntl for the best Des Moines - Houston George Bush Intcntl flight prices

You are more likely to see cheaper flights to Houston George Bush Intcntl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Houston George Bush Intcntl Airport for around $331 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Houston George Bush Intcntl Airport from Des Moines for as low as $239 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Houston George Bush Intcntl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 38% on your flight if you consider stops on a Des Moines to Houston George Bush Intcntl Airport flight.

As of March 2026, prices for Des Moines to Houston George Bush Intcntl Airport flights are approximately 117% more expensive when compared to flights at the same time last year.

Dallas (DFW) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Dallas (DFW) offer the lowest average round-trip price of $298.

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 4h 19m.

Dallas (DFW) has the shortest average layover time for this route: 1h 21m.

As of March 2026, 5 flights take off from Des Moines and land in Houston George Bush Intcntl Airport each day. The most common flight departure time for this route is 2:00PM, with 53% of daily flights taking off in the afternoon.

As of March 2026, there are 39 flights per week flying from Des Moines to Houston George Bush Intcntl Airport. The most common day of the week flights depart is Mon, with 15% of flights taking off on this day.