Cheap flights from Des Moines to Houston from $125

The month of March is, on average, the cheapest month to fly to Houston George Bush Intcntl Airport from Des Moines, with most prices found around $289. If you are unable to visit Houston George Bush Intcntl Airport during the month of March, then departing from Des Moines during the month December is also very affordable. Most momondo users find prices during this month for around $303.

The cheapest day to depart from Des Moines to Houston George Bush Intcntl Airport is on a Friday. Travelers who choose to depart for Houston George Bush Intcntl Airport on a Friday will often find tickets for as low as $513. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Houston George Bush Intcntl Airport on Monday is $700.

Our data shows that the cheapest Des Moines to Houston George Bush Intcntl Airport flights are usually those with departure times at noon. Our users have found flights to Houston George Bush Intcntl Airport at noon for as low as $456. Try not to purchase tickets in the morning because they tend to be around $595. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Houston George Bush Intcntl for the best Des Moines - Houston George Bush Intcntl flight prices

You are more likely to see cheaper flights to Houston George Bush Intcntl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Houston George Bush Intcntl Airport for around $380 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Houston George Bush Intcntl Airport from Des Moines for as low as $269 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Houston George Bush Intcntl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 36% on your flight if you consider stops on a Des Moines to Houston George Bush Intcntl Airport flight.

As of November 2026, prices for Des Moines to Houston George Bush Intcntl Airport flights are approximately 6% cheaper when compared to flights at the same time last year.

As of November 2026, 4 flights take off from Des Moines and land in Houston George Bush Intcntl Airport each day. The most common flight departure time for this route is 8:00AM, with 66% of daily flights taking off at noon.

As of November 2026, there are 33 flights per week flying from Des Moines to Houston George Bush Intcntl Airport. The most common day of the week flights depart is Mon, with 15% of flights taking off on this day.