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Cheap flights from Des Moines to the Czech Republic from $521

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Czech Republic departing on 10/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to the Czech Republic

Cheap round-trip flights

British Airways Logo
6:28 pm - 6:10 pmDSM-PRG
16h 42m2 stops
British Airways Logo
6:45 am - 11:30 pmPRG-DSM
23h 45m2 stops
$625British Airways
Find Deal
dom., dic. 7 - jue., dic. 18
Lufthansa Logo
6:50 pm - 10:25 pmDSM-PRG
20h 35m2 stops
Lufthansa Logo
1:45 pm - 9:37 pmPRG-DSM
14h 52m2 stops
$638Lufthansa
Find Deal
mié., dic. 3 - mar., dic. 16
United Airlines Logo
1:00 pm - 4:00 pmDSM-PRG
20h 00m2 stops
United Airlines Logo
6:00 am - 7:19 pmPRG-DSM
20h 19m2 stops
$644United Airlines
Find Deal
mié., oct. 8 - mié., oct. 15
Logo
11:31 am - 4:00 pmDSM-PRG
21h 29m2 stops
Logo
6:00 am - 2:23 pmPRG-DSM
15h 23m2 stops
$668
Find Deal
mié., oct. 8 - mié., oct. 15
United Airlines Logo
8:00 am - 2:05 pmDSM-PRG
23h 05m2 stops
United Airlines Logo
6:00 am - 2:23 pmPRG-DSM
15h 23m2 stops
$676United Airlines
Find Deal
mié., oct. 8 - mié., oct. 15
American Airlines Logo
6:12 pm - 5:00 pmDSM-PRG
15h 48m2 stops
American Airlines Logo
12:55 pm - 11:16 pmPRG-DSM
17h 21m2 stops
$688American Airlines
Find Deal
mié., oct. 8 - mié., oct. 15
American Airlines Logo
3:48 pm - 5:00 pmDSM-PRG
18h 12m2 stops
American Airlines Logo
6:40 am - 5:02 pmPRG-DSM
17h 22m2 stops
$709American Airlines
Find Deal
mié., oct. 8 - mié., oct. 15
Air Canada Logo
11:31 am - 10:55 amDSM-PRG
16h 24m3 stops
Air Canada Logo
6:00 am - 5:24 pmPRG-DSM
18h 24m3 stops
$888Air Canada
Find Deal
mié., oct. 8 - mié., oct. 15
Air Canada Logo
11:31 am - 10:55 amDSM-PRG
16h 24m3 stops
Air Canada Logo
11:40 am - 9:50 pmPRG-DSM
17h 10m3 stops
$893Air Canada
Find Deal
mié., oct. 8 - mié., oct. 15
Logo
5:56 pm - 5:40 pmDSM-PRG
16h 44m3 stops
Logo
8:50 am - 10:40 pmPRG-DSM
20h 50m2 stops
$1,138
Find Deal
jue., oct. 9 - jue., oct. 16

American Airlines flights from Des Moines to Czech Republic

Our best American Airlines deals on Des Moines to Czech Republic flight tickets
American Airlines
Oct 8
DSM6:12 pmDes Moines
15h 48m
2 stops
PRG5:00 pmVáclav Havel Prague
Oct 15
PRG12:55 pmVáclav Havel Prague
17h 21m
2 stops
DSM11:16 pmDes Moines
$688
Find similar
American Airlines
Oct 8
DSM3:48 pmDes Moines
18h 12m
2 stops
PRG5:00 pmVáclav Havel Prague
Oct 15
PRG6:40 amVáclav Havel Prague
17h 22m
2 stops
DSM5:02 pmDes Moines
$709
Find similar
American Airlines
Oct 10
DSM6:22 pmDes Moines
18h 43m
2 stops
PRG8:05 pmVáclav Havel Prague
Oct 17
PRG7:10 amVáclav Havel Prague
20h 01m
2 stops
DSM8:11 pmDes Moines
$730
Find similar

British Airways flights from Des Moines to Czech Republic

Our best British Airways deals on Des Moines to Czech Republic flight tickets
British Airways
Dec 7
DSM6:28 pmDes Moines
16h 42m
2 stops
PRG6:10 pmVáclav Havel Prague
Dec 18
PRG6:45 amVáclav Havel Prague
23h 45m
2 stops
DSM11:30 pmDes Moines
$625
Find similar
British Airways
Oct 8
DSM6:07 pmDes Moines
32h 13m
2 stops
PRG9:20 amVáclav Havel Prague
Oct 15
PRG9:15 pmVáclav Havel Prague
33h 08m
2 stops
DSM11:23 pmDes Moines
$670
Find similar
British Airways
Oct 9
DSM6:07 pmDes Moines
19h 03m
2 stops
PRG8:10 pmVáclav Havel Prague
Oct 16
PRG7:10 amVáclav Havel Prague
20h 01m
2 stops
DSM8:11 pmDes Moines
$720
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agosto 26, 2025.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 12/7

6:28 pm-6:10 pm

2 stops16h 42m

Václav Havel Prague

jue. 12/18

6:45 am-11:30 pm

2 stops23h 45m

$625

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 12/3

6:50 pm-10:25 pm

2 stops20h 35m

Václav Havel Prague

mar. 12/16

1:45 pm-9:37 pm

2 stops14h 52m

$638

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

1:00 pm-4:00 pm

2 stops20h 00m

Václav Havel Prague

mié. 10/15

6:00 am-7:19 pm

2 stops20h 19m

$644

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

11:31 am-4:00 pm

2 stops21h 29m

Václav Havel Prague

mié. 10/15

6:00 am-2:23 pm

2 stops15h 23m

$668

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

8:00 am-2:05 pm

2 stops23h 05m

Václav Havel Prague

mié. 10/15

6:00 am-2:23 pm

2 stops15h 23m

$676

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

6:12 pm-5:00 pm

2 stops15h 48m

Václav Havel Prague

mié. 10/15

12:55 pm-11:16 pm

2 stops17h 21m

$688

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

3:48 pm-5:00 pm

2 stops18h 12m

Václav Havel Prague

mié. 10/15

6:40 am-5:02 pm

2 stops17h 22m

$709

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

11:31 am-10:55 am

3 stops16h 24m

Václav Havel Prague

mié. 10/15

6:00 am-5:24 pm

3 stops18h 24m

$888

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mié. 10/8

11:31 am-10:55 am

3 stops16h 24m

Václav Havel Prague

mié. 10/15

11:40 am-9:50 pm

3 stops17h 10m

$893

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

jue. 10/9

5:56 pm-5:40 pm

3 stops16h 44m

Václav Havel Prague

jue. 10/16

8:50 am-10:40 pm

2 stops20h 50m

$1,138

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to the Czech Republic from

How to get the cheapest flight ticket from Des Moines to Czech Republic

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Czech Republic?

The cheapest day to depart from Des Moines to Czech Republic is on a Tuesday when prices can be found for as low as $816. The most expensive day to fly to Czech Republic is Friday, with ticket prices averaging around $1,811.

What is the cheapest time of day to depart on your flight to Czech Republic?

In the afternoon is the cheapest time of day to fly from Des Moines to Czech Republic when you can find flight prices for as low as $1,080. Flying to Czech Republic in the afternoon is an ideal time because this is during off-peak travel hours. Flights to Czech Republic are more costly in the morning, with an average ticket price of $1,157. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Cheap Des Moines to Czech Republic flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Czech Republic

Direct flights

None
There are no direct flights from Des Moines to Czech Republic. There are no popular flight routes from Des Moines to Czech Republic.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Czech Republic?

    Prices for flights from Des Moines Airport to Czech Republic are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Czech Republic?

  • How old do you have to be to fly from Des Moines Airport to Czech Republic?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Czech Republic.

  • What documentation or ID do you need to fly to Czech Republic?

    The travel and health documents required for your trip to Czech Republic can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Czech Republic. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Czech Republic

Compare and see reviews for airlines that fly from Des Moines to Czech Republic with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $588Free CancellationRating
7.4
8,943 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Czech Republic?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Czech Republic for you.

Can I find flights from Des Moines to Czech Republic with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Czech Republic flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Czech Republic?

momondo provides multiple filters to help you find the best flight to Czech Republic from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Czech Republic right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Czech Republic from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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