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Cheap flights from Des Moines to the Czech Republic from $412

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Czech Republic departing on 3/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to the Czech Republic

Cheap round-trip flights

Enter your travel dates to find the best prices.
British Airways Logo
5:01 pm - 10:50 pm
DSM
-
PRG
22h 49m
2 stops
British Airways Logo
6:50 am - 11:49 pm
PRG
-
DSM
23h 59m
2 stops
$596British Airways
Fri, May 1 - Sun, May 10
American Airlines Logo
8:03 pm - 10:50 pm
DSM
-
PRG
19h 47m
2 stops
American Airlines Logo
8:40 am - 11:49 pm
PRG
-
DSM
22h 09m
2 stops
$600American Airlines
Fri, May 1 - Sun, May 10
United Airlines Logo
6:15 am - 8:55 am
DSM
-
PRG
19h 40m
2 stops
United Airlines Logo
6:10 am - 10:45 pm
PRG
-
DSM
23h 35m
2 stops
$611United Airlines
Fri, May 1 - Sun, May 10
Multiple Airlines Logo
12:06 pm - 6:45 pm
DSM
-
PRG
23h 39m
2 stops
Multiple Airlines Logo
8:40 am - 10:26 am
PRG
-
DSM
32h 46m
2 stops
$627Multiple Airlines
Fri, May 1 - Sun, May 10
United Airlines Logo
3:28 pm - 10:25 pm
DSM
-
PRG
24h 57m
2 stops
United Airlines Logo
9:10 am - 6:15 pm
PRG
-
DSM
16h 05m
2 stops
$635United Airlines
Wed, Mar 25 - Wed, Apr 1
United Airlines Logo
1:32 pm - 10:25 pm
DSM
-
PRG
25h 53m
2 stops
United Airlines Logo
3:00 pm - 10:30 am
PRG
-
DSM
25h 30m
2 stops
$710United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
5:03 pm - 10:25 pm
DSM
-
PRG
22h 22m
2 stops
United Airlines Logo
3:00 pm - 10:30 am
PRG
-
DSM
25h 30m
2 stops
$711United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
1:32 pm - 10:25 pm
DSM
-
PRG
25h 53m
2 stops
United Airlines Logo
6:15 am - 3:07 pm
PRG
-
DSM
39h 52m
2 stops
$718United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
8:00 am - 1:05 pm
DSM
-
PRG
22h 05m
2 stops
United Airlines Logo
1:45 pm - 10:44 pm
PRG
-
DSM
38h 59m
2 stops
$723United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
9:00 am - 4:05 pm
DSM
-
PRG
25h 05m
2 stops
United Airlines Logo
6:00 am - 10:59 pm
PRG
-
DSM
23h 59m
2 stops
$809United Airlines
Thu, Mar 26 - Thu, Apr 2

United Airlines flights from Des Moines to Czech Republic

Our best United Airlines deals on Des Moines to Czech Republic flight tickets
United Airlines
May 1
DSM6:15 amDes Moines
19h 40m
2 stops
PRG8:55 amVáclav Havel Prague
May 10
PRG6:10 amVáclav Havel Prague
23h 35m
2 stops
DSM10:45 pmDes Moines
$611
United Airlines
Mar 25
DSM3:28 pmDes Moines
24h 57m
2 stops
PRG10:25 pmVáclav Havel Prague
Apr 1
PRG9:10 amVáclav Havel Prague
16h 05m
2 stops
DSM6:15 pmDes Moines
$635
United Airlines
Mar 4
DSM1:32 pmDes Moines
25h 53m
2 stops
PRG10:25 pmVáclav Havel Prague
Mar 8
PRG3:00 pmVáclav Havel Prague
25h 30m
2 stops
DSM10:30 amDes Moines
$710

Aer Lingus flights from Des Moines to Czech Republic

Our best Aer Lingus deals on Des Moines to Czech Republic flight tickets
Aer Lingus
May 26
DSM6:00 amDes Moines
21h 50m
2 stops
PRG10:50 amVáclav Havel Prague
Jun 10
PRG11:30 amVáclav Havel Prague
27h 53m
2 stops
DSM8:23 amDes Moines
$1,107
Aer Lingus
May 26
DSM5:15 amDes Moines
22h 55m
2 stops
PRG11:10 amVáclav Havel Prague
Jun 10
PRG11:50 amVáclav Havel Prague
38h 38m
2 stops
DSM7:28 pmDes Moines
$1,121

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

5:01 pm-10:50 pm

2 stops22h 49m

Václav Havel Prague

Sun 5/10

6:50 am-11:49 pm

2 stops23h 59m

$596

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

8:03 pm-10:50 pm

2 stops19h 47m

Václav Havel Prague

Sun 5/10

8:40 am-11:49 pm

2 stops22h 09m

$600

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

6:15 am-8:55 am

2 stops19h 40m

Václav Havel Prague

Sun 5/10

6:10 am-10:45 pm

2 stops23h 35m

$611

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 5/1

12:06 pm-6:45 pm

2 stops23h 39m

Václav Havel Prague

Sun 5/10

8:40 am-10:26 am

2 stops32h 46m

$627

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/25

3:28 pm-10:25 pm

2 stops24h 57m

Václav Havel Prague

Wed 4/1

9:10 am-6:15 pm

2 stops16h 05m

$635

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

1:32 pm-10:25 pm

2 stops25h 53m

Václav Havel Prague

Sun 3/8

3:00 pm-10:30 am

2 stops25h 30m

$710

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

5:03 pm-10:25 pm

2 stops22h 22m

Václav Havel Prague

Sun 3/8

3:00 pm-10:30 am

2 stops25h 30m

$711

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

1:32 pm-10:25 pm

2 stops25h 53m

Václav Havel Prague

Sun 3/8

6:15 am-3:07 pm

2 stops39h 52m

$718

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 3/4

8:00 am-1:05 pm

2 stops22h 05m

Václav Havel Prague

Sun 3/8

1:45 pm-10:44 pm

2 stops38h 59m

$723

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 3/26

9:00 am-4:05 pm

2 stops25h 05m

Václav Havel Prague

Thu 4/2

6:00 am-10:59 pm

2 stops23h 59m

$809

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to the Czech Republic from

How to get the cheapest flight ticket from Des Moines to Czech Republic

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Czech Republic flights?

You could potentially save up to 46% on your flight if you consider stops on a Des Moines to Czech Republic flight.

Cheap Des Moines to Czech Republic flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Czech Republic

Fastest flight time

15h 20m

Direct flights

None
The fastest flight from Des Moines to Czech Republic takes 15h 20m
There are no direct flights from Des Moines to Czech Republic. There are no popular flight routes from Des Moines to Czech Republic.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Czech Republic?

    Prices for flights from Des Moines Airport to Czech Republic are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Czech Republic?

  • How old do you have to be to fly from Des Moines Airport to Czech Republic?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Czech Republic.

  • What documentation or ID do you need to fly to Czech Republic?

    The travel and health documents required for your trip to Czech Republic can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Czech Republic. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Czech Republic

Compare and see reviews for airlines that fly from Des Moines to Czech Republic with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,276 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Czech Republic?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Czech Republic for you.

Can I find flights from Des Moines to Czech Republic with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Czech Republic flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Czech Republic?

momondo provides multiple filters to help you find the best flight to Czech Republic from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Czech Republic right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Czech Republic from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Fri 3/13
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