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Cheap flights from Des Moines to the Czech Republic from $375

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Czech Republic departing on 1/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to the Czech Republic

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:48 pm - 4:05 pm
DSM
-
PRG
14h 17m2 stops
Lufthansa Logo
6:15 am - 9:50 pm
PRG
-
DSM
22h 35m2 stops
$484Lufthansa
Mon, Feb 2 - Mon, Feb 9
Lufthansa Logo
6:48 pm - 4:05 pm
DSM
-
PRG
14h 17m2 stops
Lufthansa Logo
10:15 am - 9:50 pm
PRG
-
DSM
18h 35m2 stops
$494Lufthansa
Wed, Feb 4 - Wed, Feb 11
British Airways Logo
11:42 am - 5:30 pm
DSM
-
PRG
22h 48m2 stops
British Airways Logo
6:45 am - 9:04 pm
PRG
-
DSM
21h 19m2 stops
$495British Airways
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
12:06 pm - 11:40 am
DSM
-
PRG
16h 34m2 stops
Multiple Airlines Logo
8:55 am - 8:54 pm
PRG
-
DSM
18h 59m2 stops
$497Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
1:35 pm - 4:05 pm
DSM
-
PRG
19h 30m2 stops
Lufthansa Logo
7:25 am - 5:47 pm
PRG
-
DSM
17h 22m2 stops
$498Lufthansa
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
11:26 am - 11:40 am
DSM
-
PRG
17h 14m2 stops
Multiple Airlines Logo
8:55 am - 8:54 pm
PRG
-
DSM
18h 59m2 stops
$499Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
12:06 pm - 11:40 am
DSM
-
PRG
16h 34m2 stops
Multiple Airlines Logo
8:55 am - 8:54 pm
PRG
-
DSM
18h 59m2 stops
$500Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
5:05 am - 6:50 pm
DSM
-
PRG
30h 45m2 stops
Multiple Airlines Logo
7:35 pm - 11:38 pm
PRG
-
DSM
35h 03m2 stops
$501Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
United Airlines Logo
8:00 am - 1:05 pm
DSM
-
PRG
22h 05m2 stops
United Airlines Logo
7:25 am - 8:34 pm
PRG
-
DSM
20h 09m2 stops
$509United Airlines
Fri, Feb 6 - Tue, Feb 10
United Airlines Logo
6:59 pm - 4:05 pm
DSM
-
PRG
14h 06m2 stops
United Airlines Logo
6:00 am - 5:55 pm
PRG
-
DSM
18h 55m2 stops
$559United Airlines
Fri, Apr 17 - Fri, Apr 24

Lufthansa flights from Des Moines to Czech Republic

Our best Lufthansa deals on Des Moines to Czech Republic flight tickets
Lufthansa
Feb 2
DSM6:48 pmDes Moines
14h 17m
2 stops
PRG4:05 pmVáclav Havel Prague
Feb 9
PRG6:15 amVáclav Havel Prague
22h 35m
2 stops
DSM9:50 pmDes Moines
$484
Find similar
Lufthansa
Feb 4
DSM6:48 pmDes Moines
14h 17m
2 stops
PRG4:05 pmVáclav Havel Prague
Feb 11
PRG10:15 amVáclav Havel Prague
18h 35m
2 stops
DSM9:50 pmDes Moines
$494
Find similar
Lufthansa
Feb 3
DSM1:35 pmDes Moines
19h 30m
2 stops
PRG4:05 pmVáclav Havel Prague
Feb 10
PRG7:25 amVáclav Havel Prague
17h 22m
2 stops
DSM5:47 pmDes Moines
$498
Find similar

British Airways flights from Des Moines to Czech Republic

Our best British Airways deals on Des Moines to Czech Republic flight tickets
British Airways
Feb 3
DSM11:42 amDes Moines
22h 48m
2 stops
PRG5:30 pmVáclav Havel Prague
Feb 10
PRG6:45 amVáclav Havel Prague
21h 19m
2 stops
DSM9:04 pmDes Moines
$495
Find similar
British Airways
May 1
DSM6:19 pmDes Moines
21h 41m
2 stops
PRG11:00 pmVáclav Havel Prague
May 10
PRG6:55 amVáclav Havel Prague
18h 09m
2 stops
DSM6:04 pmDes Moines
$595
Find similar
British Airways
Jan 7
DSM5:01 pmDes Moines
20h 39m
2 stops
PRG8:40 pmVáclav Havel Prague
Jan 22
PRG6:45 amVáclav Havel Prague
21h 19m
2 stops
DSM9:04 pmDes Moines
$3,020
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 2/2

6:48 pm-4:05 pm

2 stops14h 17m

Václav Havel Prague

Mon 2/9

6:15 am-9:50 pm

2 stops22h 35m

$484

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 2/4

6:48 pm-4:05 pm

2 stops14h 17m

Václav Havel Prague

Wed 2/11

10:15 am-9:50 pm

2 stops18h 35m

$494

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

11:42 am-5:30 pm

2 stops22h 48m

Václav Havel Prague

Tue 2/10

6:45 am-9:04 pm

2 stops21h 19m

$495

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

12:06 pm-11:40 am

2 stops16h 34m

Václav Havel Prague

Tue 2/10

8:55 am-8:54 pm

2 stops18h 59m

$497

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

1:35 pm-4:05 pm

2 stops19h 30m

Václav Havel Prague

Tue 2/10

7:25 am-5:47 pm

2 stops17h 22m

$498

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

11:26 am-11:40 am

2 stops17h 14m

Václav Havel Prague

Tue 2/10

8:55 am-8:54 pm

2 stops18h 59m

$499

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 2/3

12:06 pm-11:40 am

2 stops16h 34m

Václav Havel Prague

Tue 2/10

8:55 am-8:54 pm

2 stops18h 59m

$500

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 2/5

5:05 am-6:50 pm

2 stops30h 45m

Václav Havel Prague

Thu 2/12

7:35 pm-11:38 pm

2 stops35h 03m

$501

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 2/6

8:00 am-1:05 pm

2 stops22h 05m

Václav Havel Prague

Tue 2/10

7:25 am-8:34 pm

2 stops20h 09m

$509

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 4/17

6:59 pm-4:05 pm

2 stops14h 06m

Václav Havel Prague

Fri 4/24

6:00 am-5:55 pm

2 stops18h 55m

$559

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to the Czech Republic from

How to get the cheapest flight ticket from Des Moines to Czech Republic

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Czech Republic?

The cheapest day to depart from Des Moines to Czech Republic is on a Tuesday when prices can be found for as low as $816. The most expensive day to fly to Czech Republic is Friday, with ticket prices averaging around $1,811.

What is the cheapest time of day to depart on your flight to Czech Republic?

In the afternoon is the cheapest time of day to fly from Des Moines to Czech Republic when you can find flight prices for as low as $1,080. Flying to Czech Republic in the afternoon is an ideal time because this is during off-peak travel hours. Flights to Czech Republic are more costly in the morning, with an average ticket price of $1,157. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Des Moines to Czech Republic flights?

You could potentially save up to 50% on your flight if you consider stops on a Des Moines to Czech Republic flight.

Cheap Des Moines to Czech Republic flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Czech Republic

Fastest flight time

14h 17m

Direct flights

None
The fastest flight from Des Moines to Czech Republic takes 14h 17m
There are no direct flights from Des Moines to Czech Republic. There are no popular flight routes from Des Moines to Czech Republic.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Czech Republic?

    Prices for flights from Des Moines Airport to Czech Republic are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Czech Republic?

  • How old do you have to be to fly from Des Moines Airport to Czech Republic?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Czech Republic.

  • What documentation or ID do you need to fly to Czech Republic?

    The travel and health documents required for your trip to Czech Republic can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Czech Republic. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Czech Republic

Compare and see reviews for airlines that fly from Des Moines to Czech Republic with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $597Free CancellationRating
7.4
9,102 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Czech Republic?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Czech Republic for you.

Can I find flights from Des Moines to Czech Republic with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Czech Republic flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Czech Republic?

momondo provides multiple filters to help you find the best flight to Czech Republic from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Czech Republic right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Czech Republic from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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