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Cheap flights from Des Moines to the Cayman Islands from $552

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Cayman Islands departing on 2/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:27 pm - 11:35 am
DSM
-
GCM
15h 08m
2 stops
Multiple Airlines Logo
2:49 pm - 10:51 pm
GCM
-
DSM
9h 02m
1 stop
$552Multiple Airlines
Thu, Feb 26 - Thu, Mar 5
United Airlines Logo
7:15 am - 3:30 pm
DSM
-
GCM
8h 15m
1 stop
United Airlines Logo
1:50 pm - 9:40 pm
GCM
-
DSM
7h 50m
1 stop
$555United Airlines
Wed, Mar 18 - Wed, Mar 25
American Airlines Logo
7:00 am - 7:15 pm
DSM
-
GCM
12h 15m
1 stop
American Airlines Logo
7:45 am - 11:49 pm
GCM
-
DSM
16h 04m
2 stops
$560American Airlines
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
5:00 am - 2:35 pm
DSM
-
GCM
8h 35m
1 stop
American Airlines Logo
1:05 pm - 11:59 pm
GCM
-
DSM
11h 54m
1 stop
$572American Airlines
Wed, Feb 25 - Wed, Mar 4
American Airlines Logo
7:15 am - 8:15 pm
DSM
-
GCM
12h 00m
2 stops
American Airlines Logo
1:05 pm - 11:40 pm
GCM
-
DSM
11h 35m
2 stops
$577American Airlines
Wed, Feb 25 - Wed, Mar 4
American Airlines Logo
7:44 pm - 1:44 pm
DSM
-
GCM
17h 00m
1 stop
American Airlines Logo
2:44 pm - 11:40 pm
GCM
-
DSM
8h 56m
1 stop
$585American Airlines
Sat, Mar 7 - Sat, Mar 14
American Airlines Logo
8:03 pm - 11:33 am
DSM
-
GCM
15h 30m
2 stops
American Airlines Logo
2:10 pm - 10:29 am
GCM
-
DSM
20h 19m
2 stops
$590American Airlines
Thu, Apr 23 - Thu, Apr 30
American Airlines Logo
7:44 pm - 1:44 pm
DSM
-
GCM
18h 00m
1 stop
American Airlines Logo
11:40 am - 11:56 pm
GCM
-
DSM
12h 16m
1 stop
$593American Airlines
Sat, Mar 21 - Sat, Mar 28
American Airlines Logo
7:44 pm - 1:44 pm
DSM
-
GCM
18h 00m
1 stop
American Airlines Logo
7:45 am - 9:59 pm
GCM
-
DSM
14h 14m
2 stops
$597American Airlines
Sat, Mar 21 - Sat, Mar 28
American Airlines Logo
7:05 pm - 1:10 pm
DSM
-
GCM
18h 05m
2 stops
American Airlines Logo
2:10 pm - 8:23 am
GCM
-
DSM
18h 13m
2 stops
$602American Airlines
Mon, Jun 1 - Fri, Jun 5

American Airlines flights from Des Moines to Cayman Islands

Our best American Airlines deals on Des Moines to Cayman Islands flight tickets
American Airlines
Mar 31
DSM7:00 amDes Moines
6h 30m
1 stop
GCM1:30 pmGeorge Town Owen Roberts Intl
Apr 7
GCM7:45 amGeorge Town Owen Roberts Intl
16h 04m
2 stops
DSM11:49 pmDes Moines
$560
American Airlines
Feb 25
DSM5:00 amDes Moines
8h 35m
1 stop
GCM2:35 pmGeorge Town Owen Roberts Intl
Mar 4
GCM1:05 pmGeorge Town Owen Roberts Intl
11h 54m
1 stop
DSM11:59 pmDes Moines
$572
American Airlines
Feb 25
DSM7:15 amDes Moines
12h 00m
2 stops
GCM8:15 pmGeorge Town Owen Roberts Intl
Mar 4
GCM1:05 pmGeorge Town Owen Roberts Intl
11h 35m
2 stops
DSM11:40 pmDes Moines
$577

Delta flights from Des Moines to Cayman Islands

Our best Delta deals on Des Moines to Cayman Islands flight tickets
Delta
Feb 14
DSM6:50 amDes Moines
6h 41m
1 stop
GCM2:31 pmGeorge Town Owen Roberts Intl
Feb 21
GCM12:25 pmGeorge Town Owen Roberts Intl
9h 55m
2 stops
DSM9:20 pmDes Moines
$658
Delta
May 19
DSM10:56 amDes Moines
24h 58m
2 stops
GCM11:54 amGeorge Town Owen Roberts Intl
May 26
GCM1:19 pmGeorge Town Owen Roberts Intl
20h 24m
2 stops
DSM9:43 amDes Moines
$682
Delta
Feb 14
DSM6:50 amDes Moines
6h 41m
1 stop
GCM2:31 pmGeorge Town Owen Roberts Intl
Feb 21
GCM12:25 pmGeorge Town Owen Roberts Intl
9h 55m
2 stops
DSM9:20 pmDes Moines
$757

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 2/26

7:27 pm-11:35 am

2 stops15h 08m

George Town Owen Roberts Intl

Thu 3/5

2:49 pm-10:51 pm

1 stop9h 02m

$552

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 3/18

7:15 am-3:30 pm

1 stop8h 15m

George Town Owen Roberts Intl

Wed 3/25

1:50 pm-9:40 pm

1 stop7h 50m

$555

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/31

7:00 am-7:15 pm

1 stop12h 15m

George Town Owen Roberts Intl

Tue 4/7

7:45 am-11:49 pm

2 stops16h 04m

$560

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 2/25

5:00 am-2:35 pm

1 stop8h 35m

George Town Owen Roberts Intl

Wed 3/4

1:05 pm-11:59 pm

1 stop11h 54m

$572

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 2/25

7:15 am-8:15 pm

2 stops12h 00m

George Town Owen Roberts Intl

Wed 3/4

1:05 pm-11:40 pm

2 stops11h 35m

$577

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 3/7

7:44 pm-1:44 pm

1 stop17h 00m

George Town Owen Roberts Intl

Sat 3/14

2:44 pm-11:40 pm

1 stop8h 56m

$585

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 4/23

8:03 pm-11:33 am

2 stops15h 30m

George Town Owen Roberts Intl

Thu 4/30

2:10 pm-10:29 am

2 stops20h 19m

$590

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 3/21

7:44 pm-1:44 pm

1 stop18h 00m

George Town Owen Roberts Intl

Sat 3/28

11:40 am-11:56 pm

1 stop12h 16m

$593

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 3/21

7:44 pm-1:44 pm

1 stop18h 00m

George Town Owen Roberts Intl

Sat 3/28

7:45 am-9:59 pm

2 stops14h 14m

$597

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 6/1

7:05 pm-1:10 pm

2 stops18h 05m

George Town Owen Roberts Intl

Fri 6/5

2:10 pm-8:23 am

2 stops18h 13m

$602

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Des Moines to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $576.

Can stopping save me money on Des Moines to Cayman Islands flights?

You could potentially save up to 52% on your flight if you consider stops on a Des Moines to Cayman Islands flight.

Cheap Des Moines to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cayman Islands

Fastest flight time

5h 56m

Direct flights

None
The fastest flight from Des Moines to Cayman Islands takes 5h 56m
There are no direct flights from Des Moines to Cayman Islands. There are no popular flight routes from Des Moines to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Cayman Islands?

    Prices for flights from Des Moines Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Cayman Islands?

  • How old do you have to be to fly from Des Moines Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The necessary travel and health documents for your Cayman Islands trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Cayman Islands

Compare and see reviews for airlines that fly from Des Moines to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $496Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights
DeltaPriceFrom $565Free CancellationRating
7.9
8,144 reviews
Search Delta flights
American AirlinesPriceFrom $575Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cayman Islands?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Cayman Islands. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Cayman Islands with flexible booking policies on momondo?

Flights from Des Moines to Cayman Islands with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Cayman Islands?

momondo helps you find the best flight between Des Moines and Cayman Islands by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cayman Islands right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Cayman Islands flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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