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Cheap flights from Des Moines to the Cayman Islands from $581

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Cayman Islands departing on 3/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to the Cayman Islands

Cheap round-trip flights

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American Airlines Logo
6:56 am - 6:51 pmDSM-GCM
11h 55m2 stops
American Airlines Logo
8:30 am - 10:50 pmGCM-DSM
14h 20m2 stops
$581American Airlines
Find Deal
Wed, Mar 11 - Wed, Mar 18
American Airlines Logo
5:05 pm - 12:05 pmDSM-GCM
18h 00m1 stop
American Airlines Logo
3:35 pm - 11:30 pmGCM-DSM
8h 55m1 stop
$599American Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 23
American Airlines Logo
6:33 am - 2:30 pmDSM-GCM
6h 57m1 stop
American Airlines Logo
4:30 pm - 11:42 pmGCM-DSM
8h 12m1 stop
$601American Airlines
Find Deal
Thu, Feb 19 - Thu, Mar 5
American Airlines Logo
6:33 am - 8:15 pmDSM-GCM
12h 42m2 stops
American Airlines Logo
8:45 am - 9:59 pmGCM-DSM
14h 14m2 stops
$606American Airlines
Find Deal
Thu, Feb 19 - Thu, Mar 5
American Airlines Logo
3:18 pm - 12:05 pmDSM-GCM
19h 47m1 stop
American Airlines Logo
3:45 pm - 11:58 pmGCM-DSM
9h 13m1 stop
$608American Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 23
American Airlines Logo
12:53 pm - 11:56 amDSM-GCM
23h 03m1 stop
American Airlines Logo
8:30 am - 10:50 pmGCM-DSM
14h 20m2 stops
$613American Airlines
Find Deal
Wed, Mar 11 - Wed, Mar 18
United Airlines Logo
6:46 pm - 4:00 pmDSM-GCM
20h 14m2 stops
United Airlines Logo
5:10 pm - 10:55 amGCM-DSM
18h 45m2 stops
$678United Airlines
Find Deal
Mon, Dec 29 - Mon, Jan 5
United Airlines Logo
3:14 pm - 1:45 pmDSM-GCM
21h 31m1 stop
United Airlines Logo
5:10 pm - 10:55 amGCM-DSM
18h 45m2 stops
$699United Airlines
Find Deal
Mon, Dec 29 - Mon, Jan 5
United Airlines Logo
6:46 pm - 4:00 pmDSM-GCM
20h 14m2 stops
United Airlines Logo
5:30 pm - 10:55 amGCM-DSM
18h 25m2 stops
$725United Airlines
Find Deal
Sat, Dec 27 - Sat, Jan 10
Multiple Airlines Logo
11:35 am - 2:00 pmDSM-GCM
25h 25m3 stops
Multiple Airlines Logo
1:30 pm - 1:54 pmGCM-DSM
25h 24m2 stops
$1,004Multiple Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 23

American Airlines flights from Des Moines to Cayman Islands

Our best American Airlines deals on Des Moines to Cayman Islands flight tickets
American Airlines
Mar 11
DSM6:56 amDes Moines
11h 55m
2 stops
GCM6:51 pmGeorge Town Owen Roberts Intl
Mar 18
GCM8:30 amGeorge Town Owen Roberts Intl
14h 20m
2 stops
DSM10:50 pmDes Moines
$581
Find similar
American Airlines
Dec 16
DSM5:05 pmDes Moines
18h 00m
1 stop
GCM12:05 pmGeorge Town Owen Roberts Intl
Dec 23
GCM3:35 pmGeorge Town Owen Roberts Intl
8h 55m
1 stop
DSM11:30 pmDes Moines
$599
Find similar
American Airlines
Feb 19
DSM6:33 amDes Moines
6h 57m
1 stop
GCM2:30 pmGeorge Town Owen Roberts Intl
Mar 5
GCM4:30 pmGeorge Town Owen Roberts Intl
8h 12m
1 stop
DSM11:42 pmDes Moines
$601
Find similar

United Airlines flights from Des Moines to Cayman Islands

Our best United Airlines deals on Des Moines to Cayman Islands flight tickets
United Airlines
Dec 29
DSM6:46 pmDes Moines
20h 14m
2 stops
GCM4:00 pmGeorge Town Owen Roberts Intl
Jan 5
GCM5:10 pmGeorge Town Owen Roberts Intl
18h 45m
2 stops
DSM10:55 amDes Moines
$678
Find similar
United Airlines
Dec 29
DSM3:14 pmDes Moines
21h 31m
1 stop
GCM1:45 pmGeorge Town Owen Roberts Intl
Jan 5
GCM5:10 pmGeorge Town Owen Roberts Intl
18h 45m
2 stops
DSM10:55 amDes Moines
$699
Find similar
United Airlines
Dec 27
DSM6:46 pmDes Moines
20h 14m
2 stops
GCM4:00 pmGeorge Town Owen Roberts Intl
Jan 10
GCM5:30 pmGeorge Town Owen Roberts Intl
18h 25m
2 stops
DSM10:55 amDes Moines
$725
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 3/11

6:56 am-6:51 pm

2 stops11h 55m

George Town Owen Roberts Intl

Wed 3/18

8:30 am-10:50 pm

2 stops14h 20m

$581

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 12/16

5:05 pm-12:05 pm

1 stop18h 00m

George Town Owen Roberts Intl

Tue 12/23

3:35 pm-11:30 pm

1 stop8h 55m

$599

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 2/19

6:33 am-2:30 pm

1 stop6h 57m

George Town Owen Roberts Intl

Thu 3/5

4:30 pm-11:42 pm

1 stop8h 12m

$601

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 2/19

6:33 am-8:15 pm

2 stops12h 42m

George Town Owen Roberts Intl

Thu 3/5

8:45 am-9:59 pm

2 stops14h 14m

$606

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 12/16

3:18 pm-12:05 pm

1 stop19h 47m

George Town Owen Roberts Intl

Tue 12/23

3:45 pm-11:58 pm

1 stop9h 13m

$608

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 3/11

12:53 pm-11:56 am

1 stop23h 03m

George Town Owen Roberts Intl

Wed 3/18

8:30 am-10:50 pm

2 stops14h 20m

$613

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 12/29

6:46 pm-4:00 pm

2 stops20h 14m

George Town Owen Roberts Intl

Mon 1/5

5:10 pm-10:55 am

2 stops18h 45m

$678

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 12/29

3:14 pm-1:45 pm

1 stop21h 31m

George Town Owen Roberts Intl

Mon 1/5

5:10 pm-10:55 am

2 stops18h 45m

$699

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 12/27

6:46 pm-4:00 pm

2 stops20h 14m

George Town Owen Roberts Intl

Sat 1/10

5:30 pm-10:55 am

2 stops18h 25m

$725

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 12/16

11:35 am-2:00 pm

3 stops25h 25m

George Town Owen Roberts Intl

Tue 12/23

1:30 pm-1:54 pm

2 stops25h 24m

$1,004

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Des Moines to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $576.

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Friday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $514. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $663.

What is the cheapest time of day to depart on your flight to Cayman Islands?

According to our data, the cheapest time of day to fly to Cayman Islands is in the morning. momondo users have found flights departing from Des Moines to Cayman Islands in the morning for as low as $608. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $638 on average. Flights to Cayman Islands from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Des Moines to Cayman Islands flights?

You could potentially save up to 37% on your flight if you consider stops on a Des Moines to Cayman Islands flight.

Cheap Des Moines to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cayman Islands

Direct flights

None
There are no direct flights from Des Moines to Cayman Islands. There are no popular flight routes from Des Moines to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Cayman Islands?

    Prices for flights from Des Moines Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Cayman Islands?

  • How old do you have to be to fly from Des Moines Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The necessary travel and health documents for your Cayman Islands trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Cayman Islands

Compare and see reviews for airlines that fly from Des Moines to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $555Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
DeltaPriceFrom $565Free CancellationRating
7.9
8,001 reviews
Search Delta flights
American AirlinesPriceFrom $575Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cayman Islands?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Cayman Islands. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Cayman Islands with flexible booking policies on momondo?

Flights from Des Moines to Cayman Islands with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Cayman Islands?

momondo helps you find the best flight between Des Moines and Cayman Islands by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cayman Islands right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Cayman Islands flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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