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Cheap flights from Des Moines to the Cayman Islands from $421

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Cayman Islands departing on 1/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:44 pm - 4:55 pm
DSM
-
GCM
21h 11m1 stop
Multiple Airlines Logo
2:34 pm - 10:09 pm
GCM
-
DSM
32h 35m2 stops
$421Multiple Airlines
Fri, Jan 2 - Sat, Jan 10
Multiple Airlines Logo
6:44 pm - 4:55 pm
DSM
-
GCM
21h 11m1 stop
Multiple Airlines Logo
2:34 pm - 10:09 pm
GCM
-
DSM
32h 35m2 stops
$433Multiple Airlines
Fri, Jan 2 - Sat, Jan 10
Multiple Airlines Logo
6:44 pm - 4:55 pm
DSM
-
GCM
21h 11m1 stop
Multiple Airlines Logo
2:49 pm - 10:19 am
GCM
-
DSM
20h 30m2 stops
$439Multiple Airlines
Fri, Jan 2 - Sun, Jan 11
Multiple Airlines Logo
6:44 pm - 4:55 pm
DSM
-
GCM
21h 11m1 stop
Multiple Airlines Logo
2:49 pm - 10:19 am
GCM
-
DSM
20h 30m2 stops
$453Multiple Airlines
Fri, Jan 2 - Sun, Jan 11
Multiple Airlines Logo
11:09 am - 1:53 pm
DSM
-
GCM
49h 44m2 stops
Multiple Airlines Logo
11:25 am - 10:17 pm
GCM
-
DSM
11h 52m1 stop
$493Multiple Airlines
Fri, Jan 9 - Fri, Jan 16
American Airlines Logo
5:05 am - 2:25 pm
DSM
-
GCM
9h 20m1 stop
American Airlines Logo
2:50 pm - 9:44 pm
GCM
-
DSM
6h 54m1 stop
$496American Airlines
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
7:15 am - 7:15 pm
DSM
-
GCM
12h 00m2 stops
American Airlines Logo
2:50 pm - 11:07 am
GCM
-
DSM
20h 17m2 stops
$501American Airlines
Tue, Mar 31 - Tue, Apr 7
Multiple Airlines Logo
11:09 am - 1:53 pm
DSM
-
GCM
49h 44m2 stops
Multiple Airlines Logo
2:49 pm - 10:46 pm
GCM
-
DSM
8h 57m1 stop
$503Multiple Airlines
Fri, Jan 9 - Sun, Jan 18
Multiple Airlines Logo
6:15 pm - 5:20 pm
DSM
-
GCM
22h 05m1 stop
Multiple Airlines Logo
2:34 pm - 10:09 pm
GCM
-
DSM
32h 35m2 stops
$514Multiple Airlines
Sun, Jan 4 - Sat, Jan 10
American Airlines Logo
7:10 am - 1:00 pm
DSM
-
GCM
5h 50m1 stop
American Airlines Logo
2:50 pm - 9:44 pm
GCM
-
DSM
6h 54m1 stop
$526American Airlines
Thu, Apr 23 - Thu, Apr 30

American Airlines flights from Des Moines to Cayman Islands

Our best American Airlines deals on Des Moines to Cayman Islands flight tickets
American Airlines
Mar 31
DSM5:05 amDes Moines
9h 20m
1 stop
GCM2:25 pmGeorge Town Owen Roberts Intl
Apr 7
GCM2:50 pmGeorge Town Owen Roberts Intl
6h 54m
1 stop
DSM9:44 pmDes Moines
$496
Find similar
American Airlines
Mar 31
DSM7:15 amDes Moines
12h 00m
2 stops
GCM7:15 pmGeorge Town Owen Roberts Intl
Apr 7
GCM2:50 pmGeorge Town Owen Roberts Intl
20h 17m
2 stops
DSM11:07 amDes Moines
$501
Find similar
American Airlines
Apr 23
DSM7:10 amDes Moines
5h 50m
1 stop
GCM1:00 pmGeorge Town Owen Roberts Intl
Apr 30
GCM2:50 pmGeorge Town Owen Roberts Intl
6h 54m
1 stop
DSM9:44 pmDes Moines
$526
Find similar

Delta flights from Des Moines to Cayman Islands

Our best Delta deals on Des Moines to Cayman Islands flight tickets
Delta
Dec 20
DSM12:08 pmDes Moines
25h 19m
2 stops
GCM2:27 pmGeorge Town Owen Roberts Intl
Dec 24
GCM1:52 pmGeorge Town Owen Roberts Intl
22h 36m
2 stops
DSM11:28 amDes Moines
$531
Find similar
Delta
Jan 10
DSM5:35 amDes Moines
7h 25m
1 stop
GCM2:00 pmGeorge Town Owen Roberts Intl
Jan 17
GCM3:25 pmGeorge Town Owen Roberts Intl
8h 04m
1 stop
DSM10:29 pmDes Moines
$556
Find similar
Delta
Jan 5
DSM5:35 amDes Moines
7h 41m
1 stop
GCM2:16 pmGeorge Town Owen Roberts Intl
Jan 13
GCM2:05 pmGeorge Town Owen Roberts Intl
9h 24m
1 stop
DSM10:29 pmDes Moines
$576
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:44 pm-4:55 pm

1 stop21h 11m

George Town Owen Roberts Intl

Sat 1/10

2:34 pm-10:09 pm

2 stops32h 35m

$421

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:44 pm-4:55 pm

1 stop21h 11m

George Town Owen Roberts Intl

Sat 1/10

2:34 pm-10:09 pm

2 stops32h 35m

$433

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:44 pm-4:55 pm

1 stop21h 11m

George Town Owen Roberts Intl

Sun 1/11

2:49 pm-10:19 am

2 stops20h 30m

$439

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

6:44 pm-4:55 pm

1 stop21h 11m

George Town Owen Roberts Intl

Sun 1/11

2:49 pm-10:19 am

2 stops20h 30m

$453

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/9

11:09 am-1:53 pm

2 stops49h 44m

George Town Owen Roberts Intl

Fri 1/16

11:25 am-10:17 pm

1 stop11h 52m

$493

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/31

5:05 am-2:25 pm

1 stop9h 20m

George Town Owen Roberts Intl

Tue 4/7

2:50 pm-9:44 pm

1 stop6h 54m

$496

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/31

7:15 am-7:15 pm

2 stops12h 00m

George Town Owen Roberts Intl

Tue 4/7

2:50 pm-11:07 am

2 stops20h 17m

$501

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/9

11:09 am-1:53 pm

2 stops49h 44m

George Town Owen Roberts Intl

Sun 1/18

2:49 pm-10:46 pm

1 stop8h 57m

$503

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sun 1/4

6:15 pm-5:20 pm

1 stop22h 05m

George Town Owen Roberts Intl

Sat 1/10

2:34 pm-10:09 pm

2 stops32h 35m

$514

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 4/23

7:10 am-1:00 pm

1 stop5h 50m

George Town Owen Roberts Intl

Thu 4/30

2:50 pm-9:44 pm

1 stop6h 54m

$526

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Des Moines to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $576.

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Friday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $514. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $663.

What is the cheapest time of day to depart on your flight to Cayman Islands?

According to our data, the cheapest time of day to fly to Cayman Islands is in the morning. momondo users have found flights departing from Des Moines to Cayman Islands in the morning for as low as $608. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $638 on average. Flights to Cayman Islands from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Des Moines to Cayman Islands flights?

You could potentially save up to 52% on your flight if you consider stops on a Des Moines to Cayman Islands flight.

Cheap Des Moines to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cayman Islands

Fastest flight time

6h 01m

Direct flights

None
The fastest flight from Des Moines to Cayman Islands takes 6h 01m
There are no direct flights from Des Moines to Cayman Islands. There are no popular flight routes from Des Moines to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Cayman Islands?

    Prices for flights from Des Moines Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Cayman Islands?

  • How old do you have to be to fly from Des Moines Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The necessary travel and health documents for your Cayman Islands trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Cayman Islands

Compare and see reviews for airlines that fly from Des Moines to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $496Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights
DeltaPriceFrom $565Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $575Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cayman Islands?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Cayman Islands. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Cayman Islands with flexible booking policies on momondo?

Flights from Des Moines to Cayman Islands with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Cayman Islands?

momondo helps you find the best flight between Des Moines and Cayman Islands by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cayman Islands right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Cayman Islands flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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