Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to the Cayman Islands from $613

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Cayman Islands departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:10 pm - 12:10 pm
DSM
-
GCM
17h 00m
2 stops
Southwest Logo
1:05 pm - 11:05 pm
GCM
-
DSM
10h 00m
2 stops
$613Southwest
Mon, Apr 13 - Fri, Apr 17
Southwest Logo
6:30 pm - 12:10 pm
DSM
-
GCM
17h 40m
2 stops
Southwest Logo
1:05 pm - 10:10 pm
GCM
-
DSM
9h 05m
2 stops
$678Southwest
Wed, May 6 - Wed, May 13
American Airlines Logo
6:12 pm - 11:25 am
DSM
-
GCM
17h 13m
1 stop
American Airlines Logo
12:35 pm - 12:15 am
GCM
-
DSM
11h 40m
1 stop
$681American Airlines
Sat, Sep 5 - Wed, Sep 9
American Airlines Logo
6:12 pm - 1:10 pm
DSM
-
GCM
18h 58m
2 stops
American Airlines Logo
12:35 pm - 11:28 pm
GCM
-
DSM
10h 53m
2 stops
$686American Airlines
Sat, Sep 5 - Wed, Sep 9
United Airlines Logo
8:15 am - 12:30 pm
DSM
-
GCM
28h 15m
1 stop
United Airlines Logo
1:35 pm - 10:45 pm
GCM
-
DSM
9h 10m
1 stop
$694United Airlines
Thu, May 7 - Thu, May 14
Multiple Airlines Logo
4:57 pm - 4:05 pm
DSM
-
GCM
47h 08m
2 stops
Multiple Airlines Logo
8:15 am - 4:18 pm
GCM
-
DSM
8h 03m
1 stop
$701Multiple Airlines
Sun, Jul 19 - Sun, Aug 9
American Airlines Logo
6:12 pm - 11:25 am
DSM
-
GCM
17h 13m
1 stop
American Airlines Logo
3:30 pm - 11:07 pm
GCM
-
DSM
7h 37m
1 stop
$706American Airlines
Sat, Aug 8 - Sat, Aug 22
American Airlines Logo
6:26 pm - 11:31 am
DSM
-
GCM
17h 05m
1 stop
American Airlines Logo
12:35 pm - 11:59 pm
GCM
-
DSM
11h 24m
2 stops
$707American Airlines
Wed, May 6 - Wed, May 13
American Airlines Logo
7:32 pm - 11:10 am
DSM
-
GCM
15h 38m
2 stops
American Airlines Logo
12:25 pm - 11:26 pm
GCM
-
DSM
11h 01m
2 stops
$711American Airlines
Sat, Aug 8 - Sat, Aug 22
American Airlines Logo
3:20 pm - 11:00 am
DSM
-
GCM
19h 40m
2 stops
American Airlines Logo
12:35 pm - 10:18 pm
GCM
-
DSM
9h 43m
1 stop
$712American Airlines
Thu, May 7 - Thu, May 14

American Airlines flights from Des Moines to Cayman Islands

Our best American Airlines deals on Des Moines to Cayman Islands flight tickets
American Airlines
Sep 5
DSM6:12 pmDes Moines
17h 13m
1 stop
GCM11:25 amGeorge Town Owen Roberts Intl
Sep 9
GCM12:35 pmGeorge Town Owen Roberts Intl
11h 40m
1 stop
DSM12:15 amDes Moines
$681
American Airlines
Sep 5
DSM6:12 pmDes Moines
18h 58m
2 stops
GCM1:10 pmGeorge Town Owen Roberts Intl
Sep 9
GCM12:35 pmGeorge Town Owen Roberts Intl
10h 53m
2 stops
DSM11:28 pmDes Moines
$686
American Airlines
Aug 8
DSM6:12 pmDes Moines
17h 13m
1 stop
GCM11:25 amGeorge Town Owen Roberts Intl
Aug 22
GCM3:30 pmGeorge Town Owen Roberts Intl
7h 37m
1 stop
DSM11:07 pmDes Moines
$706

United Airlines flights from Des Moines to Cayman Islands

Our best United Airlines deals on Des Moines to Cayman Islands flight tickets
United Airlines
May 7
DSM8:15 amDes Moines
28h 15m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
May 14
GCM1:35 pmGeorge Town Owen Roberts Intl
9h 10m
1 stop
DSM10:45 pmDes Moines
$694
United Airlines
Jul 17
DSM6:20 amDes Moines
6h 10m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Aug 1
GCM1:50 pmGeorge Town Owen Roberts Intl
20h 32m
1 stop
DSM10:22 amDes Moines
$740
United Airlines
Jul 17
DSM8:30 pmDes Moines
16h 00m
2 stops
GCM12:30 pmGeorge Town Owen Roberts Intl
Aug 1
GCM4:15 pmGeorge Town Owen Roberts Intl
18h 07m
2 stops
DSM10:22 amDes Moines
$763

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Mon 4/13

7:10 pm-12:10 pm

2 stops17h 00m

George Town Owen Roberts Intl

Fri 4/17

1:05 pm-11:05 pm

2 stops10h 00m

$613

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 5/6

6:30 pm-12:10 pm

2 stops17h 40m

George Town Owen Roberts Intl

Wed 5/13

1:05 pm-10:10 pm

2 stops9h 05m

$678

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 9/5

6:12 pm-11:25 am

1 stop17h 13m

George Town Owen Roberts Intl

Wed 9/9

12:35 pm-12:15 am

1 stop11h 40m

$681

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 9/5

6:12 pm-1:10 pm

2 stops18h 58m

George Town Owen Roberts Intl

Wed 9/9

12:35 pm-11:28 pm

2 stops10h 53m

$686

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 5/7

8:15 am-12:30 pm

1 stop28h 15m

George Town Owen Roberts Intl

Thu 5/14

1:35 pm-10:45 pm

1 stop9h 10m

$694

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sun 7/19

4:57 pm-4:05 pm

2 stops47h 08m

George Town Owen Roberts Intl

Sun 8/9

8:15 am-4:18 pm

1 stop8h 03m

$701
Quickest round-trip

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 8/8

6:12 pm-11:25 am

1 stop17h 13m

George Town Owen Roberts Intl

Sat 8/22

3:30 pm-11:07 pm

1 stop7h 37m

$706

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 5/6

6:26 pm-11:31 am

1 stop17h 05m

George Town Owen Roberts Intl

Wed 5/13

12:35 pm-11:59 pm

2 stops11h 24m

$707

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 8/8

7:32 pm-11:10 am

2 stops15h 38m

George Town Owen Roberts Intl

Sat 8/22

12:25 pm-11:26 pm

2 stops11h 01m

$711

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 5/7

3:20 pm-11:00 am

2 stops19h 40m

George Town Owen Roberts Intl

Thu 5/14

12:35 pm-10:18 pm

1 stop9h 43m

$712

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Des Moines to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $576.

Can stopping save me money on Des Moines to Cayman Islands flights?

You could potentially save up to 52% on your flight if you consider stops on a Des Moines to Cayman Islands flight.

Cheap Des Moines to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cayman Islands

Fastest flight time

5h 41m

Direct flights

None
The fastest flight from Des Moines to Cayman Islands takes 5h 41m
There are no direct flights from Des Moines to Cayman Islands. There are no popular flight routes from Des Moines to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Cayman Islands?

    Prices for flights from Des Moines Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Cayman Islands?

  • How old do you have to be to fly from Des Moines Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The necessary travel and health documents for your Cayman Islands trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Cayman Islands

Compare and see reviews for airlines that fly from Des Moines to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $496Free CancellationRating
7.4
9,483 reviews
Search United Airlines flights
DeltaPriceFrom $565Free CancellationRating
7.9
8,331 reviews
Search Delta flights
American AirlinesPriceFrom $575Free CancellationRating
7.1
11,495 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cayman Islands?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Cayman Islands. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Cayman Islands with flexible booking policies on momondo?

Flights from Des Moines to Cayman Islands with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Cayman Islands?

momondo helps you find the best flight between Des Moines and Cayman Islands by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cayman Islands right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Cayman Islands flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Cayman Islands trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 4/25
Sat 5/2
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the Cayman Islands

Popular cities in the Cayman Islands

Popular flights according to clicks in the last 7 days on momondo
Flights to George Townfrom $231
Flights to Cayman Bracfrom $325
Flights to Little Caymanfrom $363