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Cheap flights from Des Moines to the Cayman Islands from $519

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to the Cayman Islands departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to the Cayman Islands

Cheap round-trip flights

American Airlines Logo
5:38 pm - 11:25 amDSM-GCM
17h 47m1 stop
American Airlines Logo
12:25 pm - 11:06 pmGCM-DSM
10h 41m1 stop
$519American Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
American Airlines Logo
5:38 pm - 11:10 amDSM-GCM
17h 32m2 stops
American Airlines Logo
12:10 pm - 11:13 pmGCM-DSM
11h 03m2 stops
$524American Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
American Airlines Logo
3:49 pm - 11:10 amDSM-GCM
19h 21m2 stops
American Airlines Logo
12:10 pm - 8:58 amGCM-DSM
20h 48m2 stops
$525American Airlines
Find Deal
Sat, Aug 23 - Sat, Aug 30
American Airlines Logo
4:23 pm - 11:25 amDSM-GCM
19h 02m1 stop
American Airlines Logo
3:15 pm - 10:30 pmGCM-DSM
7h 15m1 stop
$531American Airlines
Find Deal
Sat, Aug 23 - Sat, Aug 30
United Airlines Logo
6:46 pm - 4:00 pmDSM-GCM
20h 14m2 stops
United Airlines Logo
2:50 pm - 9:36 pmGCM-DSM
7h 46m1 stop
$576United Airlines
Find Deal
Thu, Jan 1 - Thu, Jan 8
United Airlines Logo
6:46 pm - 4:00 pmDSM-GCM
20h 14m2 stops
United Airlines Logo
2:25 pm - 10:20 amGCM-DSM
20h 55m2 stops
$580United Airlines
Find Deal
Thu, Jan 1 - Thu, Jan 8
Delta Logo
5:50 am - 12:30 pmDSM-GCM
5h 40m1 stop
Delta Logo
2:00 pm - 10:28 pmGCM-DSM
9h 28m1 stop
$601Delta
Find Deal
Fri, Jan 2 - Thu, Jan 8
American Airlines Logo
5:49 am - 4:00 pmDSM-GCM
9h 11m2 stops
American Airlines Logo
2:15 pm - 8:58 amGCM-DSM
19h 43m2 stops
$605American Airlines
Find Deal
Fri, Jan 2 - Thu, Jan 8
Logo
1:20 pm - 9:20 pmDSM-GCM
31h 00m3 stops
Logo
7:00 am - 3:40 pmGCM-DSM
33h 40m3 stops
$930
Find Deal
Thu, Jan 1 - Thu, Jan 8
Logo
2:50 pm - 4:05 pmDSM-GCM
24h 15m3 stops
Logo
11:30 am - 3:40 pmGCM-DSM
29h 10m3 stops
$1,022
Find Deal
Fri, Jan 2 - Wed, Jan 7

United Airlines flights from Des Moines to Cayman Islands

Our best United Airlines deals on Des Moines to Cayman Islands flight tickets
United Airlines
Jan 1
DSM6:46 pmDes Moines
20h 14m
2 stops
GCM4:00 pmGeorge Town Owen Roberts Intl
Jan 8
GCM2:50 pmGeorge Town Owen Roberts Intl
7h 46m
1 stop
DSM9:36 pmDes Moines
$576
Find similar
United Airlines
Jan 1
DSM6:46 pmDes Moines
20h 14m
2 stops
GCM4:00 pmGeorge Town Owen Roberts Intl
Jan 8
GCM2:25 pmGeorge Town Owen Roberts Intl
20h 55m
2 stops
DSM10:20 amDes Moines
$580
Find similar
United Airlines
Dec 27
DSM6:46 pmDes Moines
20h 49m
2 stops
GCM4:35 pmGeorge Town Owen Roberts Intl
Jan 10
GCM5:30 pmGeorge Town Owen Roberts Intl
25h 03m
2 stops
DSM5:33 pmDes Moines
$817
Find similar

American Airlines flights from Des Moines to Cayman Islands

Our best American Airlines deals on Des Moines to Cayman Islands flight tickets
American Airlines
Sep 12
DSM5:38 pmDes Moines
17h 47m
1 stop
GCM11:25 amGeorge Town Owen Roberts Intl
Sep 19
GCM12:25 pmGeorge Town Owen Roberts Intl
10h 41m
1 stop
DSM11:06 pmDes Moines
$519
Find similar
American Airlines
Sep 12
DSM5:38 pmDes Moines
17h 32m
2 stops
GCM11:10 amGeorge Town Owen Roberts Intl
Sep 19
GCM12:10 pmGeorge Town Owen Roberts Intl
11h 03m
2 stops
DSM11:13 pmDes Moines
$524
Find similar
American Airlines
Aug 23
DSM3:49 pmDes Moines
19h 21m
2 stops
GCM11:10 amGeorge Town Owen Roberts Intl
Aug 30
GCM12:10 pmGeorge Town Owen Roberts Intl
20h 48m
2 stops
DSM8:58 amDes Moines
$525
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 9/12

5:38 pm-11:25 am

1 stop17h 47m

George Town Owen Roberts Intl

Fri 9/19

12:25 pm-11:06 pm

1 stop10h 41m

$519

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 9/12

5:38 pm-11:10 am

2 stops17h 32m

George Town Owen Roberts Intl

Fri 9/19

12:10 pm-11:13 pm

2 stops11h 03m

$524

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 8/23

3:49 pm-11:10 am

2 stops19h 21m

George Town Owen Roberts Intl

Sat 8/30

12:10 pm-8:58 am

2 stops20h 48m

$525

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 8/23

4:23 pm-11:25 am

1 stop19h 02m

George Town Owen Roberts Intl

Sat 8/30

3:15 pm-10:30 pm

1 stop7h 15m

$531

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 1/1

6:46 pm-4:00 pm

2 stops20h 14m

George Town Owen Roberts Intl

Thu 1/8

2:50 pm-9:36 pm

1 stop7h 46m

$576

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 1/1

6:46 pm-4:00 pm

2 stops20h 14m

George Town Owen Roberts Intl

Thu 1/8

2:25 pm-10:20 am

2 stops20h 55m

$580

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

5:50 am-12:30 pm

1 stop5h 40m

George Town Owen Roberts Intl

Thu 1/8

2:00 pm-10:28 pm

1 stop9h 28m

$601

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

5:49 am-4:00 pm

2 stops9h 11m

George Town Owen Roberts Intl

Thu 1/8

2:15 pm-8:58 am

2 stops19h 43m

$605

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Thu 1/1

1:20 pm-9:20 pm

3 stops31h 00m

George Town Owen Roberts Intl

Thu 1/8

7:00 am-3:40 pm

3 stops33h 40m

$930

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 1/2

2:50 pm-4:05 pm

3 stops24h 15m

George Town Owen Roberts Intl

Wed 1/7

11:30 am-3:40 pm

3 stops29h 10m

$1,022

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Des Moines to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Friday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $514. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $663.

What is the cheapest time of day to depart on your flight to Cayman Islands?

According to our data, the cheapest time of day to fly to Cayman Islands is in the morning. momondo users have found flights departing from Des Moines to Cayman Islands in the morning for as low as $608. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $638 on average. Flights to Cayman Islands from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Cheap Des Moines to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cayman Islands

Best Price Found

$519

Fastest flight time

5h 40m

Direct flights

None

Airports in Cayman Islands

1 airport
The best flight deal from Des Moines to Cayman Islands found on momondo in the last 72 hours is $519
The fastest flight from Des Moines to Cayman Islands takes 5h 40m
There are no direct flights from Des Moines to Cayman Islands. Popular non-direct route for this connection is Des Moines Airport - George Town Owen Roberts Intl Airport.
There is 1 airport near Cayman Islands: George Town Owen Roberts Intl (GCM)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Cayman Islands?

    Prices for flights from Des Moines Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Cayman Islands?

  • How old do you have to be to fly from Des Moines Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The necessary travel and health documents for your Cayman Islands trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Cayman Islands

Compare and see reviews for airlines that fly from Des Moines to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $457Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
American AirlinesPriceFrom $555Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cayman Islands?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Cayman Islands. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Cayman Islands with flexible booking policies on momondo?

Flights from Des Moines to Cayman Islands with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Cayman Islands?

momondo helps you find the best flight between Des Moines and Cayman Islands by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cayman Islands right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Cayman Islands flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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