Cheap flights from Denver to Panama from $158

The month of August is, on average, the cheapest month to fly to Panama from Denver, with most prices found around $535. If you don’t want to visit Panama in August, then you should wait until May to fly from Denver, when ticket prices are also cheap, with an average price of $542.

According to our data, Tuesday is the cheapest day to fly to Panama from Denver. The lowest ticket price found for a Tuesday departure recently was $530. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Denver to Panama for around $605.

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama flight prices

You are more likely to see cheaper flights to Panama from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $622 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Denver for as low as $534 on momondo.

There are 3 cabin classes available to choose from on Denver Intl to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Denver to Panama.

The number of flights available between Denver and Panama is 2 per day as of March 2026. The most frequent departure time is 9:00PM, with 100% of daily flights leaving in the evening.

As of March 2026, 14 flights take off from Denver and land in Panama each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.