Cheap flights from Denver to Panama from $281

The month of April is, on average, the cheapest month to fly to Panama from Denver, with most prices found around $597. If you don’t want to visit Panama in April, then you should wait until May to fly from Denver, when ticket prices are also cheap, with an average price of $607.

According to our data, Tuesday is the cheapest day to fly to Panama from Denver. The lowest ticket price found for a Tuesday departure recently was $539. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Denver to Panama for around $640.

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama flight prices

You are more likely to see cheaper flights to Panama from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $675 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Denver for as low as $585 on momondo.

There are 3 cabin classes available to choose from on Denver to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 86% on your flight if you consider stops on a Denver to Panama flight.

American Airlines and Aeromexico are the most popular carriers operating from Denver Intl to Panama

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama from Denver according to our data. Copa Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

The number of flights available between Denver and Panama is 1 per day as of September 2026. The most frequent departure time is 10:00PM, with 100% of daily flights leaving in the evening.

As of September 2026, 8 flights take off from Denver and land in Panama each week. The most common flight departure day for this route is Mon, with 25% of weekly flights taking off on this day.