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Cheap flights from Denver to Panama from $222

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Panama departing on 11/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:34 am - 3:54 pmDEN-PTY
13h 20m1 stop
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
13h 00m1 stop
$463Multiple Airlines
Find Deal
Wed, Nov 5 - Wed, Nov 12
Multiple Airlines Logo
12:59 am - 4:06 pmDEN-PTY
14h 07m2 stops
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
13h 00m1 stop
$479Multiple Airlines
Find Deal
Tue, Oct 28 - Wed, Nov 5
Multiple Airlines Logo
12:59 am - 7:20 pmDEN-PTY
16h 21m2 stops
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
13h 00m1 stop
$496Multiple Airlines
Find Deal
Tue, Nov 11 - Fri, Nov 14
Multiple Airlines Logo
12:34 am - 4:36 pmDEN-PTY
14h 02m1 stop
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
13h 00m1 stop
$498Multiple Airlines
Find Deal
Thu, Nov 6 - Wed, Nov 12
Multiple Airlines Logo
12:34 am - 2:30 pmDEN-PTY
11h 56m1 stop
Multiple Airlines Logo
10:47 am - 10:29 pmPTY-DEN
13h 42m2 stops
$503Multiple Airlines
Find Deal
Fri, Nov 7 - Sat, Nov 15
Copa Airlines Logo
9:38 pm - 5:33 amDEN-PTY
5h 55mnonstop
Copa Airlines Logo
12:56 pm - 5:16 pmPTY-DEN
6h 20mnonstop
$535Copa Airlines
Find Deal
Sat, Jan 17 - Wed, Jan 28
Copa Airlines Logo
9:38 pm - 5:33 amDEN-PTY
5h 55mnonstop
Copa Airlines Logo
12:56 pm - 5:17 pmPTY-DEN
6h 21mnonstop
$548Copa Airlines
Find Deal
Thu, Nov 27 - Wed, Dec 3
American Airlines Logo
11:59 pm - 3:38 pmDEN-PTY
13h 39m1 stop
American Airlines Logo
2:27 pm - 11:49 pmPTY-DEN
11h 22m1 stop
$550American Airlines
Find Deal
Sat, Jan 17 - Wed, Jan 28
American Airlines Logo
8:50 am - 1:43 pmDEN-PTY
26h 53m1 stop
American Airlines Logo
4:42 pm - 11:16 amPTY-DEN
20h 34m2 stops
$552American Airlines
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Thu, Nov 27 - Wed, Dec 3
Delta Logo
4:40 pm - 2:02 pmDEN-PTY
19h 22m1 stop
Delta Logo
3:27 pm - 11:54 pmPTY-DEN
10h 27m1 stop
$561Delta
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Sun, Jan 18 - Mon, Jan 26

Copa Airlines flights from Denver to Panama

Our best Copa Airlines deals on Denver to Panama flight tickets
Copa Airlines
Jan 17
DEN9:38 pmDenver Intl
5h 55m
PTY5:33 amPanama City Tocumen Intl
Jan 28
PTY12:56 pmPanama City Tocumen Intl
6h 20m
DEN5:16 pmDenver Intl
$535
Find similar
Copa Airlines
Nov 27
DEN9:38 pmDenver Intl
5h 55m
PTY5:33 amPanama City Tocumen Intl
Dec 3
PTY12:56 pmPanama City Tocumen Intl
6h 21m
DEN5:17 pmDenver Intl
$548
Find similar
Copa Airlines
Nov 7
DEN9:38 pmDenver Intl
5h 55m
PTY5:33 amPanama City Tocumen Intl
Nov 12
PTY12:56 pmPanama City Tocumen Intl
6h 21m
DEN5:17 pmDenver Intl
$574
Find similar

American Airlines flights from Denver to Panama

Our best American Airlines deals on Denver to Panama flight tickets
American Airlines
Jan 17
DEN11:59 pmDenver Intl
13h 39m
1 stop
PTY3:38 pmPanama City Tocumen Intl
Jan 28
PTY2:27 pmPanama City Tocumen Intl
11h 22m
1 stop
DEN11:49 pmDenver Intl
$550
Find similar
American Airlines
Nov 27
DEN8:50 amDenver Intl
26h 53m
1 stop
PTY1:43 pmPanama City Tocumen Intl
Dec 3
PTY4:42 pmPanama City Tocumen Intl
20h 34m
2 stops
DEN11:16 amDenver Intl
$552
Find similar
American Airlines
Feb 18
DEN11:59 pmDenver Intl
13h 01m
2 stops
PTY3:00 pmPanama City Tocumen Intl
Feb 28
PTY4:40 pmPanama City Tocumen Intl
20h 41m
2 stops
DEN11:21 amDenver Intl
$554
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 8, 2025.
Use the filters below to find and compare flights from Denver to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 11/5

12:34 am-3:54 pm

1 stop13h 20m

Panama City Tocumen Intl

Wed 11/12

9:33 pm-8:33 am

1 stop13h 00m

$463

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Tue 10/28

12:59 am-4:06 pm

2 stops14h 07m

Panama City Tocumen Intl

Wed 11/5

9:33 pm-8:33 am

1 stop13h 00m

$479

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Tue 11/11

12:59 am-7:20 pm

2 stops16h 21m

Panama City Tocumen Intl

Fri 11/14

9:33 pm-8:33 am

1 stop13h 00m

$496

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Thu 11/6

12:34 am-4:36 pm

1 stop14h 02m

Panama City Tocumen Intl

Wed 11/12

9:33 pm-8:33 am

1 stop13h 00m

$498

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 11/7

12:34 am-2:30 pm

1 stop11h 56m

Panama City Tocumen Intl

Sat 11/15

10:47 am-10:29 pm

2 stops13h 42m

$503

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 1/17

9:38 pm-5:33 am

Nonstop5h 55m

Panama City Tocumen Intl

Wed 1/28

12:56 pm-5:16 pm

Nonstop6h 20m

$535

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Thu 11/27

9:38 pm-5:33 am

Nonstop5h 55m

Panama City Tocumen Intl

Wed 12/3

12:56 pm-5:17 pm

Nonstop6h 21m

$548

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 1/17

11:59 pm-3:38 pm

1 stop13h 39m

Panama City Tocumen Intl

Wed 1/28

2:27 pm-11:49 pm

1 stop11h 22m

$550

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Thu 11/27

8:50 am-1:43 pm

1 stop26h 53m

Panama City Tocumen Intl

Wed 12/3

4:42 pm-11:16 am

2 stops20h 34m

$552

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sun 1/18

4:40 pm-2:02 pm

1 stop19h 22m

Panama City Tocumen Intl

Mon 1/26

3:27 pm-11:54 pm

1 stop10h 27m

$561

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Denver to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Denver, with most prices found around $542. If you don’t want to visit Panama in August, then you should wait until October to fly from Denver, when ticket prices are also cheap, with an average price of $586.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Denver. The lowest ticket price found for a Tuesday departure recently was $483. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Denver to Panama for around $630.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Denver to Panama when you can find flight prices for as low as $592. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $733 per ticket.

What is the cheapest Denver Intl to Panama flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $651 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Denver for as low as $578 on momondo.

What cabin class options are available on Denver Intl to Panama flights?

There are 3 cabin classes available to choose from on Denver Intl to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama flights?

You could potentially save up to 8% on your flight if you consider stops on a Denver to Panama flight.

Cheap Denver to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama

Best Price Found

$174

Fastest flight time

5h 45m

Direct flights

Every day

Airports in Panama

1 airport
The best one-way flight to Panama from Denver in the past 72 hours is $174. The best round-trip flight deal from Denver to Panama found on momondo in the last 72 hours is $401.
The fastest flight from Denver to Panama takes 5h 45m
Direct flights go from Denver to Panama every day.
There is 1 airport near Panama: Panama City Tocumen Intl (PTY)
Search flight deals

  • When did momondo last update prices for flights from Denver Intl Airport to Panama?

    Prices for flights from Denver Intl Airport to Panama were last updated today.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama?

  • How old do you have to be to fly from Denver Intl Airport to Panama?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama?

Best airlines flying from Denver to Panama

Compare and see reviews for airlines that fly from Denver to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $492Free CancellationRating
7.6
1,542 reviews
Search Copa Airlines flights
DeltaPriceFrom $518Free CancellationRating
7.9
7,969 reviews
Search Delta flights
American AirlinesPriceFrom $527Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $527Free CancellationRating
7.4
8,966 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Denver to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Denver to Panama with flexible booking policies on momondo?

Flights from Denver to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Denver to Panama?

momondo helps you find the best flight between Denver and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Panama right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama, momondo offers a useful price alert feature which will track prices for flights to Panama from Denver and alert you when they change.

An easier way to manage your Panama trip

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Fri 11/7
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