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Cheap flights from Chicago to Santiago from $270

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Santiago departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
12:48 pm - 7:40 am
MDW
-
SCL
15h 52m1 stop
LATAM Airlines Logo
11:25 pm - 11:59 am
SCL
-
MDW
15h 34m2 stops
$628LATAM Airlines
Tue, Jan 27 - Tue, Feb 10
Multiple Airlines Logo
6:05 pm - 10:15 pm
ORD
-
SCL
25h 10m2 stops
Multiple Airlines Logo
7:15 am - 9:39 am
SCL
-
ORD
28h 24m2 stops
$628Multiple Airlines
Mon, Jan 5 - Tue, Mar 10
LATAM Airlines Logo
1:57 pm - 6:55 am
ORD
-
SCL
13h 58m1 stop
LATAM Airlines Logo
8:50 am - 11:55 pm
SCL
-
ORD
18h 05m2 stops
$630LATAM Airlines
Thu, Jan 29 - Thu, Feb 5
LATAM Airlines Logo
10:49 am - 7:00 am
MDW
-
SCL
18h 11m2 stops
LATAM Airlines Logo
10:10 pm - 9:55 am
SCL
-
MDW
13h 45m1 stop
$631LATAM Airlines
Tue, Mar 10 - Tue, Mar 17
Multiple Airlines Logo
6:05 pm - 10:15 pm
ORD
-
SCL
25h 10m2 stops
Multiple Airlines Logo
1:35 am - 9:20 pm
SCL
-
ORD
21h 45m1 stop
$631Multiple Airlines
Mon, Jan 5 - Mon, Mar 9
Multiple Airlines Logo
8:43 pm - 6:40 am
ORD
-
SCL
30h 57m2 stops
Multiple Airlines Logo
11:25 pm - 4:47 pm
SCL
-
ORD
20h 22m1 stop
$632Multiple Airlines
Fri, Feb 6 - Mon, Feb 23
Multiple Airlines Logo
6:57 pm - 10:15 pm
ORD
-
SCL
24h 18m2 stops
Multiple Airlines Logo
9:05 pm - 10:42 pm
SCL
-
ORD
28h 37m3 stops
$634Multiple Airlines
Thu, Jan 8 - Fri, Jan 23
LATAM Airlines Logo
1:15 pm - 7:15 am
ORD
-
SCL
17h 00m1 stop
LATAM Airlines Logo
10:55 pm - 5:41 pm
SCL
-
ORD
19h 46m1 stop
$635LATAM Airlines
Fri, May 15 - Mon, May 25
Copa Airlines Logo
8:34 am - 11:49 pm
ORD
-
SCL
13h 15m1 stop
Copa Airlines Logo
3:32 am - 1:04 am
SCL
-
ORD
23h 32m1 stop
$638Copa Airlines
Tue, Mar 10 - Sat, Mar 14
Delta Logo
9:32 am - 7:00 am
MDW
-
SCL
19h 28m2 stops
Delta Logo
10:10 pm - 12:29 pm
SCL
-
MDW
16h 19m2 stops
$655Delta
Tue, Mar 10 - Tue, Mar 17

LATAM Airlines flights from Chicago to Santiago

Our best LATAM Airlines deals on Chicago to Santiago flight tickets
LATAM Airlines
Jan 27
MDW12:48 pmChicago Midway
15h 52m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Feb 10
SCL11:25 pmSantiago Arturo Merino Benitez
15h 34m
2 stops
MDW11:59 amChicago Midway
$628
Find similar
LATAM Airlines
Jan 29
ORD1:57 pmChicago O'Hare Intl
13h 58m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Feb 5
SCL8:50 amSantiago Arturo Merino Benitez
18h 05m
2 stops
ORD11:55 pmChicago O'Hare Intl
$630
Find similar
LATAM Airlines
Mar 10
MDW10:49 amChicago Midway
18h 11m
2 stops
SCL7:00 amSantiago Arturo Merino Benitez
Mar 17
SCL10:10 pmSantiago Arturo Merino Benitez
13h 45m
1 stop
MDW9:55 amChicago Midway
$631
Find similar

Delta flights from Chicago to Santiago

Our best Delta deals on Chicago to Santiago flight tickets
Delta
Jun 2
ORD5:55 pmChicago O'Hare Intl
19h 10m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Jun 7
SCL7:45 amSantiago Arturo Merino Benitez
17h 10m
2 stops
ORD11:55 pmChicago O'Hare Intl
$650
Find similar
Delta
Jan 27
MDW1:29 pmChicago Midway
15h 11m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
Feb 5
SCL11:10 pmSantiago Arturo Merino Benitez
16h 36m
2 stops
MDW12:46 pmChicago Midway
$655
Find similar
Delta
May 30
ORD5:00 pmChicago O'Hare Intl
36h 50m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Jun 6
SCL7:45 pmSantiago Arturo Merino Benitez
17h 56m
2 stops
ORD12:41 pmChicago O'Hare Intl
$658
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 1/27

12:48 pm-7:40 am

1 stop15h 52m

Santiago Arturo Merino Benitez

Tue 2/10

11:25 pm-11:59 am

2 stops15h 34m

$628

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 1/5

6:05 pm-10:15 pm

2 stops25h 10m

Santiago Arturo Merino Benitez

Tue 3/10

7:15 am-9:39 am

2 stops28h 24m

$628

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 1/29

1:57 pm-6:55 am

1 stop13h 58m

Santiago Arturo Merino Benitez

Thu 2/5

8:50 am-11:55 pm

2 stops18h 05m

$630

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 3/10

10:49 am-7:00 am

2 stops18h 11m

Santiago Arturo Merino Benitez

Tue 3/17

10:10 pm-9:55 am

1 stop13h 45m

$631

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 1/5

6:05 pm-10:15 pm

2 stops25h 10m

Santiago Arturo Merino Benitez

Mon 3/9

1:35 am-9:20 pm

1 stop21h 45m

$631

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Fri 2/6

8:43 pm-6:40 am

2 stops30h 57m

Santiago Arturo Merino Benitez

Mon 2/23

11:25 pm-4:47 pm

1 stop20h 22m

$632

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 1/8

6:57 pm-10:15 pm

2 stops24h 18m

Santiago Arturo Merino Benitez

Fri 1/23

9:05 pm-10:42 pm

3 stops28h 37m

$634

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Fri 5/15

1:15 pm-7:15 am

1 stop17h 00m

Santiago Arturo Merino Benitez

Mon 5/25

10:55 pm-5:41 pm

1 stop19h 46m

$635

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Tue 3/10

8:34 am-11:49 pm

1 stop13h 15m

Santiago Arturo Merino Benitez

Sat 3/14

3:32 am-1:04 am

1 stop23h 32m

$638

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 3/10

9:32 am-7:00 am

2 stops19h 28m

Santiago Arturo Merino Benitez

Tue 3/17

10:10 pm-12:29 pm

2 stops16h 19m

$655

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Chicago to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from Chicago to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $659. If you don’t want to visit Santiago in September, then you should wait until April to fly from Chicago, when ticket prices are also cheap, with an average price of $775.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $847. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $992.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Chicago to Santiago when you can find flight prices for as low as $843. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $942 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $870 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Chicago for as low as $673 on momondo.

Can stopping save me money on Chicago to Santiago flights?

You could potentially save up to 26% on your flight if you consider stops on a Chicago to Santiago flight.

How have Chicago to Santiago flight prices changed over time?

As of December 2025, prices for Chicago to Santiago flights are approximately 52% cheaper when compared to flights at the same time last year.

When to book flights from Chicago to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Santiago (CHI to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Santiago

Fastest flight time

12h 02m

Direct flights

None
The fastest flight from Chicago to Santiago takes 12h 02m
There are no direct flights from Chicago to Santiago. There are no popular flight routes from Chicago to Santiago.
Search flight deals

  • How far is Chicago to Santiago Arturo Merino Benitez by plane?

    The distance between Chicago and Santiago Arturo Merino Benitez is about 5311.0 mi. 12h 02m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Chicago to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Chicago to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents you'll need for your trip to Santiago Arturo Merino Benitez Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Chicago to Santiago?

Best airlines flying from Chicago to Santiago

Compare and see reviews for airlines that fly from Chicago to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $484Free CancellationRating
7.1
10,534 reviews
Search Air Canada flights
AviancaPriceFrom $564Free CancellationRating
6.6
2,490 reviews
Search Avianca flights
United AirlinesPriceFrom $626Free CancellationRating
7.4
9,093 reviews
Search United Airlines flights
DeltaPriceFrom $626Free CancellationRating
7.9
8,008 reviews
Search Delta flights
Copa AirlinesPriceFrom $638Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $639Free CancellationRating
7.2
11,055 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $684Free CancellationRating
7.5
1,893 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Santiago?

It is quick and easy to find Chicago to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Chicago to Santiago with flexible booking policies on momondo?

Flights from Chicago to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Santiago?

momondo helps you find the best flight between Chicago and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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