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Cheap flights from Chicago to Santiago from $286

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Santiago departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:09 pm - 7:40 am
MDW
-
SCL
16h 31m2 stops
Delta Logo
10:10 pm - 12:29 pm
SCL
-
MDW
16h 19m2 stops
$655Delta
mar., mar. 10 - mar., mar. 17
Delta Logo
1:56 pm - 7:40 am
ORD
-
SCL
15h 44m2 stops
Delta Logo
10:30 pm - 4:43 pm
SCL
-
ORD
20h 13m2 stops
$655Delta
lun., mar. 9 - jue., mar. 19
Multiple Airlines Logo
5:15 am - 2:40 pm
ORD
-
SCL
30h 25m2 stops
Multiple Airlines Logo
9:05 pm - 10:06 pm
SCL
-
ORD
28h 01m2 stops
$661Multiple Airlines
lun., feb. 9 - mar., feb. 17
Multiple Airlines Logo
6:05 pm - 5:35 am
ORD
-
SCL
32h 30m1 stop
Multiple Airlines Logo
7:35 am - 8:20 pm
SCL
-
ORD
15h 45m1 stop
$664Multiple Airlines
mié., ene. 7 - mié., ene. 28
LATAM Airlines Logo
9:43 am - 7:40 am
ORD
-
SCL
19h 57m1 stop
LATAM Airlines Logo
10:10 pm - 6:46 pm
SCL
-
ORD
22h 36m1 stop
$670LATAM Airlines
mié., mar. 11 - sáb., mar. 21
Multiple Airlines Logo
6:05 pm - 10:15 pm
ORD
-
SCL
25h 10m2 stops
Multiple Airlines Logo
3:45 pm - 11:06 pm
SCL
-
ORD
33h 21m3 stops
$674Multiple Airlines
lun., ene. 5 - mar., mar. 10
LATAM Airlines Logo
4:30 pm - 6:10 am
MDW
-
SCL
34h 40m1 stop
LATAM Airlines Logo
11:10 pm - 9:53 am
SCL
-
MDW
13h 43m1 stop
$678LATAM Airlines
sáb., ene. 24 - jue., ene. 29
LATAM Airlines Logo
4:30 pm - 6:10 am
MDW
-
SCL
34h 40m1 stop
LATAM Airlines Logo
10:15 pm - 10:22 pm
SCL
-
MDW
27h 07m2 stops
$683LATAM Airlines
sáb., ene. 24 - sáb., ene. 31
LATAM Airlines Logo
1:05 pm - 12:40 pm
MDW
-
SCL
22h 35m3 stops
LATAM Airlines Logo
10:30 am - 9:51 am
SCL
-
MDW
24h 21m2 stops
$685LATAM Airlines
mar., abr. 28 - mar., may. 5
Delta Logo
6:00 am - 7:40 am
MDW
-
SCL
22h 40m1 stop
Delta Logo
11:10 pm - 11:59 am
SCL
-
MDW
15h 49m1 stop
$757Delta
lun., feb. 9 - mar., feb. 17

Delta flights from Chicago to Santiago

Our best Delta deals on Chicago to Santiago flight tickets
Delta
Mar 10
MDW1:09 pmChicago Midway
16h 31m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
Mar 17
SCL10:10 pmSantiago Arturo Merino Benitez
16h 19m
2 stops
MDW12:29 pmChicago Midway
$655
Find similar
Delta
Feb 9
MDW6:00 amChicago Midway
22h 40m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Feb 17
SCL11:10 pmSantiago Arturo Merino Benitez
15h 49m
1 stop
MDW11:59 amChicago Midway
$757
Find similar
Delta
Jan 7
MDW11:21 amChicago Midway
17h 19m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Jan 28
SCL11:10 pmSantiago Arturo Merino Benitez
13h 43m
1 stop
MDW9:53 amChicago Midway
$764
Find similar

LATAM Airlines flights from Chicago to Santiago

Our best LATAM Airlines deals on Chicago to Santiago flight tickets
LATAM Airlines
Mar 11
ORD9:43 amChicago O'Hare Intl
19h 57m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 21
SCL10:10 pmSantiago Arturo Merino Benitez
22h 36m
1 stop
ORD6:46 pmChicago O'Hare Intl
$670
Find similar
LATAM Airlines
Jan 24
MDW4:30 pmChicago Midway
34h 40m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Jan 29
SCL11:10 pmSantiago Arturo Merino Benitez
13h 43m
1 stop
MDW9:53 amChicago Midway
$678
Find similar
LATAM Airlines
Jan 24
MDW4:30 pmChicago Midway
34h 40m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Jan 31
SCL10:15 pmSantiago Arturo Merino Benitez
27h 07m
2 stops
MDW10:22 pmChicago Midway
$683
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

mar. 3/10

1:09 pm-7:40 am

2 stops16h 31m

Santiago Arturo Merino Benitez

mar. 3/17

10:10 pm-12:29 pm

2 stops16h 19m

$655

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

lun. 3/9

1:56 pm-7:40 am

2 stops15h 44m

Santiago Arturo Merino Benitez

jue. 3/19

10:30 pm-4:43 pm

2 stops20h 13m

$655

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

lun. 2/9

5:15 am-2:40 pm

2 stops30h 25m

Santiago Arturo Merino Benitez

mar. 2/17

9:05 pm-10:06 pm

2 stops28h 01m

$661

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

mié. 1/7

6:05 pm-5:35 am

1 stop32h 30m

Santiago Arturo Merino Benitez

mié. 1/28

7:35 am-8:20 pm

1 stop15h 45m

$664

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

mié. 3/11

9:43 am-7:40 am

1 stop19h 57m

Santiago Arturo Merino Benitez

sáb. 3/21

10:10 pm-6:46 pm

1 stop22h 36m

$670

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

lun. 1/5

6:05 pm-10:15 pm

2 stops25h 10m

Santiago Arturo Merino Benitez

mar. 3/10

3:45 pm-11:06 pm

3 stops33h 21m

$674

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

sáb. 1/24

4:30 pm-6:10 am

1 stop34h 40m

Santiago Arturo Merino Benitez

jue. 1/29

11:10 pm-9:53 am

1 stop13h 43m

$678

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

sáb. 1/24

4:30 pm-6:10 am

1 stop34h 40m

Santiago Arturo Merino Benitez

sáb. 1/31

10:15 pm-10:22 pm

2 stops27h 07m

$683

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

mar. 4/28

1:05 pm-12:40 pm

3 stops22h 35m

Santiago Arturo Merino Benitez

mar. 5/5

10:30 am-9:51 am

2 stops24h 21m

$685

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

lun. 2/9

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

mar. 2/17

11:10 pm-11:59 am

1 stop15h 49m

$757

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Chicago to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from Chicago to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $659. If you don’t want to visit Santiago in September, then you should wait until April to fly from Chicago, when ticket prices are also cheap, with an average price of $775.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $847. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $992.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Chicago to Santiago when you can find flight prices for as low as $843. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $942 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $870 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Chicago for as low as $673 on momondo.

Can stopping save me money on Chicago to Santiago flights?

You could potentially save up to 26% on your flight if you consider stops on a Chicago to Santiago flight.

How have Chicago to Santiago flight prices changed over time?

As of December 2025, prices for Chicago to Santiago flights are approximately 52% cheaper when compared to flights at the same time last year.

When to book flights from Chicago to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Santiago (CHI to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Santiago

Fastest flight time

12h 35m

Direct flights

None
The fastest flight from Chicago to Santiago takes 12h 35m
There are no direct flights from Chicago to Santiago. There are no popular flight routes from Chicago to Santiago.
Search flight deals

  • How far is Chicago to Santiago Arturo Merino Benitez by plane?

    The distance between Chicago and Santiago Arturo Merino Benitez is about 5311.0 mi. 12h 35m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Chicago to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Chicago to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents you'll need for your trip to Santiago Arturo Merino Benitez Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Chicago to Santiago?

Best airlines flying from Chicago to Santiago

Compare and see reviews for airlines that fly from Chicago to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $484Free CancellationRating
7.1
10,516 reviews
Search Air Canada flights
AviancaPriceFrom $564Free CancellationRating
6.6
2,480 reviews
Search Avianca flights
United AirlinesPriceFrom $626Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
DeltaPriceFrom $626Free CancellationRating
7.9
8,005 reviews
Search Delta flights
Copa AirlinesPriceFrom $638Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $639Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $684Free CancellationRating
7.5
1,888 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Santiago?

It is quick and easy to find Chicago to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Chicago to Santiago with flexible booking policies on momondo?

Flights from Chicago to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Santiago?

momondo helps you find the best flight between Chicago and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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