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Cheap flights from Chicago to Santiago from $261

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Santiago departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:34 pm - 5:40 am
ORD
-
SCL
34h 06m
2 stops
Multiple Airlines Logo
10:30 am - 6:15 pm
SCL
-
ORD
32h 45m
1 stop
$549Multiple Airlines
Sat, Apr 18 - Fri, May 8
Multiple Airlines Logo
6:34 pm - 6:40 am
ORD
-
SCL
35h 06m
2 stops
Multiple Airlines Logo
11:00 pm - 6:15 pm
SCL
-
ORD
20h 15m
1 stop
$551Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
6:34 pm - 9:15 pm
ORD
-
SCL
25h 41m
2 stops
Multiple Airlines Logo
11:00 pm - 6:15 pm
SCL
-
ORD
20h 15m
1 stop
$569Multiple Airlines
Thu, Apr 23 - Mon, May 4
Multiple Airlines Logo
6:34 pm - 6:40 am
ORD
-
SCL
35h 06m
2 stops
Multiple Airlines Logo
11:55 pm - 1:15 pm
SCL
-
ORD
14h 20m
1 stop
$573Multiple Airlines
Sun, Apr 19 - Sun, Apr 26
Multiple Airlines Logo
6:34 pm - 9:15 pm
ORD
-
SCL
25h 41m
2 stops
Multiple Airlines Logo
11:55 pm - 1:15 pm
SCL
-
ORD
14h 20m
1 stop
$574Multiple Airlines
Thu, Apr 23 - Thu, May 7
Copa Airlines Logo
8:06 am - 11:26 pm
ORD
-
SCL
14h 20m
1 stop
Copa Airlines Logo
4:17 am - 1:13 am
SCL
-
ORD
21h 56m
1 stop
$585Copa Airlines
Sun, Apr 19 - Sun, Apr 26
LATAM Airlines Logo
10:45 am - 7:40 am
MDW
-
SCL
18h 55m
1 stop
LATAM Airlines Logo
10:10 pm - 9:56 am
SCL
-
MDW
13h 46m
1 stop
$597LATAM Airlines
Mon, Mar 9 - Thu, Mar 19
LATAM Airlines Logo
6:00 am - 5:35 am
MDW
-
SCL
21h 35m
2 stops
LATAM Airlines Logo
7:15 am - 9:56 am
SCL
-
MDW
28h 41m
3 stops
$602LATAM Airlines
Sun, Mar 8 - Wed, Mar 11
LATAM Airlines Logo
6:00 am - 7:40 am
MDW
-
SCL
23h 40m
1 stop
LATAM Airlines Logo
10:10 pm - 9:56 am
SCL
-
MDW
13h 46m
1 stop
$605LATAM Airlines
Sun, Mar 8 - Wed, Mar 11
LATAM Airlines Logo
10:49 am - 7:40 am
MDW
-
SCL
17h 51m
1 stop
LATAM Airlines Logo
11:10 pm - 10:21 am
SCL
-
MDW
14h 11m
1 stop
$626LATAM Airlines
Mon, Mar 2 - Fri, Mar 6

Copa Airlines flights from Chicago to Santiago

Our best Copa Airlines deals on Chicago to Santiago flight tickets
Copa Airlines
Apr 19
ORD8:06 amChicago O'Hare Intl
14h 20m
1 stop
SCL11:26 pmSantiago Arturo Merino Benitez
Apr 26
SCL4:17 amSantiago Arturo Merino Benitez
21h 56m
1 stop
ORD1:13 amChicago O'Hare Intl
$585
Copa Airlines
Mar 29
ORD7:56 amChicago O'Hare Intl
14h 38m
1 stop
SCL12:34 amSantiago Arturo Merino Benitez
Apr 9
SCL4:17 amSantiago Arturo Merino Benitez
21h 56m
1 stop
ORD1:13 amChicago O'Hare Intl
$605
Copa Airlines
Apr 20
ORD8:06 amChicago O'Hare Intl
17h 14m
1 stop
SCL2:20 amSantiago Arturo Merino Benitez
May 4
SCL11:17 amSantiago Arturo Merino Benitez
14h 58m
1 stop
ORD1:15 amChicago O'Hare Intl
$635

Avianca flights from Chicago to Santiago

Our best Avianca deals on Chicago to Santiago flight tickets
Avianca
May 8
ORD2:35 pmChicago O'Hare Intl
21h 50m
1 stop
SCL1:25 pmSantiago Arturo Merino Benitez
May 15
SCL2:30 pmSantiago Arturo Merino Benitez
23h 45m
1 stop
ORD1:15 pmChicago O'Hare Intl
$615
Avianca
Apr 18
ORD2:35 pmChicago O'Hare Intl
12h 40m
1 stop
SCL4:15 amSantiago Arturo Merino Benitez
May 3
SCL11:55 pmSantiago Arturo Merino Benitez
14h 20m
1 stop
ORD1:15 pmChicago O'Hare Intl
$643
Avianca
Mar 15
ORD11:20 pmChicago O'Hare Intl
14h 00m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
Mar 28
SCL7:25 amSantiago Arturo Merino Benitez
15h 55m
1 stop
ORD9:20 pmChicago O'Hare Intl
$675

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Sat 4/18

6:34 pm-5:40 am

2 stops34h 06m

Santiago Arturo Merino Benitez

Fri 5/8

10:30 am-6:15 pm

1 stop32h 45m

$549

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Wed 4/15

6:34 pm-6:40 am

2 stops35h 06m

Santiago Arturo Merino Benitez

Wed 4/22

11:00 pm-6:15 pm

1 stop20h 15m

$551

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 4/23

6:34 pm-9:15 pm

2 stops25h 41m

Santiago Arturo Merino Benitez

Mon 5/4

11:00 pm-6:15 pm

1 stop20h 15m

$569

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Sun 4/19

6:34 pm-6:40 am

2 stops35h 06m

Santiago Arturo Merino Benitez

Sun 4/26

11:55 pm-1:15 pm

1 stop14h 20m

$573

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 4/23

6:34 pm-9:15 pm

2 stops25h 41m

Santiago Arturo Merino Benitez

Thu 5/7

11:55 pm-1:15 pm

1 stop14h 20m

$574

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Sun 4/19

8:06 am-11:26 pm

1 stop14h 20m

Santiago Arturo Merino Benitez

Sun 4/26

4:17 am-1:13 am

1 stop21h 56m

$585

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Mon 3/9

10:45 am-7:40 am

1 stop18h 55m

Santiago Arturo Merino Benitez

Thu 3/19

10:10 pm-9:56 am

1 stop13h 46m

$597

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Sun 3/8

6:00 am-5:35 am

2 stops21h 35m

Santiago Arturo Merino Benitez

Wed 3/11

7:15 am-9:56 am

3 stops28h 41m

$602

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Sun 3/8

6:00 am-7:40 am

1 stop23h 40m

Santiago Arturo Merino Benitez

Wed 3/11

10:10 pm-9:56 am

1 stop13h 46m

$605

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Mon 3/2

10:49 am-7:40 am

1 stop17h 51m

Santiago Arturo Merino Benitez

Fri 3/6

11:10 pm-10:21 am

1 stop14h 11m

$626

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Chicago to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from Chicago to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $659. If you don’t want to visit Santiago in September, then you should wait until January to fly from Chicago, when ticket prices are also cheap, with an average price of $714.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $848 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Chicago for as low as $673 on momondo.

Can stopping save me money on Chicago to Santiago flights?

You could potentially save up to 45% on your flight if you consider stops on a Chicago to Santiago flight.

How have Chicago to Santiago flight prices changed over time?

As of January 2026, prices for Chicago to Santiago flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from Chicago to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Santiago (CHI to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Santiago

Fastest flight time

12h 54m

Direct flights

None
The fastest flight from Chicago to Santiago takes 12h 54m
There are no direct flights from Chicago to Santiago. There are no popular flight routes from Chicago to Santiago.
Search flight deals

  • How far is Chicago to Santiago Arturo Merino Benitez by plane?

    The distance between Chicago and Santiago Arturo Merino Benitez is about 5311.0 mi. 12h 54m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Chicago to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Chicago to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents you'll need for your trip to Santiago Arturo Merino Benitez Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Chicago to Santiago?

Best airlines flying from Chicago to Santiago

Compare and see reviews for airlines that fly from Chicago to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $468Free CancellationRating
7.5
1,912 reviews
Search LATAM Airlines flights
Air CanadaPriceFrom $484Free CancellationRating
7.1
10,660 reviews
Search Air Canada flights
Copa AirlinesPriceFrom $537Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
AviancaPriceFrom $564Free CancellationRating
6.6
2,487 reviews
Search Avianca flights
DeltaPriceFrom $583Free CancellationRating
7.9
8,121 reviews
Search Delta flights
American AirlinesPriceFrom $630Free CancellationRating
7.2
11,198 reviews
Search American Airlines flights
United AirlinesPriceFrom $713Free CancellationRating
7.4
9,207 reviews
Search United Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Santiago?

It is quick and easy to find Chicago to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Chicago to Santiago with flexible booking policies on momondo?

Flights from Chicago to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Santiago?

momondo helps you find the best flight between Chicago and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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