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Cheap flights from Chicago to Santiago from $262

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Santiago departing on 10/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Multiple Airlines Logo
10:27 am - 10:15 pmORD-SCL
33h 48m2 stops
Multiple Airlines Logo
5:50 am - 12:30 pmSCL-ORD
33h 40m2 stops
$569Multiple Airlines
Find Deal
Mon, Oct 27 - Sun, Nov 9
Multiple Airlines Logo
10:27 am - 10:15 pmORD-SCL
33h 48m2 stops
Multiple Airlines Logo
10:50 am - 9:22 amSCL-ORD
24h 32m1 stop
$592Multiple Airlines
Find Deal
Thu, Oct 16 - Thu, Oct 30
Multiple Airlines Logo
1:35 pm - 10:15 pmORD-SCL
29h 40m2 stops
Multiple Airlines Logo
6:00 am - 8:57 amSCL-ORD
29h 57m1 stop
$595Multiple Airlines
Find Deal
Sun, Nov 16 - Fri, Nov 21
Avianca Logo
2:35 pm - 5:15 amORD-SCL
12h 40m1 stop
Avianca Logo
1:35 am - 8:20 pmSCL-ORD
21h 45m1 stop
$663Avianca
Find Deal
Mon, Oct 20 - Tue, Nov 11
Avianca Logo
10:20 pm - 3:20 pmORD-SCL
14h 00m1 stop
Avianca Logo
7:25 am - 8:20 pmSCL-ORD
15h 55m1 stop
$664Avianca
Find Deal
Thu, Nov 13 - Mon, Nov 17
Copa Airlines Logo
7:59 am - 12:04 amORD-SCL
14h 05m1 stop
Copa Airlines Logo
4:47 am - 12:21 amSCL-ORD
21h 34m1 stop
$672Copa Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
LATAM Airlines Logo
6:30 pm - 6:15 pmMDW-SCL
21h 45m2 stops
LATAM Airlines Logo
9:40 pm - 11:48 amSCL-MDW
16h 08m1 stop
$739LATAM Airlines
Find Deal
Sun, Sep 28 - Wed, Oct 1
LATAM Airlines Logo
12:48 pm - 6:50 amMDW-SCL
16h 02m2 stops
LATAM Airlines Logo
10:55 pm - 11:53 amSCL-MDW
14h 58m2 stops
$752LATAM Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21
Delta Logo
10:40 am - 6:35 amMDW-SCL
16h 55m2 stops
Delta Logo
8:20 am - 11:32 pmSCL-MDW
18h 12m2 stops
$764Delta
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Tue, Nov 4 - Mon, Nov 10
Delta Logo
10:35 am - 5:50 amMDW-SCL
16h 15m2 stops
Delta Logo
11:15 pm - 12:35 pmSCL-MDW
16h 20m2 stops
$768Delta
Find Deal
Tue, Jan 27 - Tue, Feb 10

Delta flights from Chicago to Santiago

Our best Delta deals on Chicago to Santiago flight tickets
Delta
Nov 4
MDW10:40 amChicago Midway
16h 55m
2 stops
SCL6:35 amSantiago Arturo Merino Benitez
Nov 10
SCL8:20 amSantiago Arturo Merino Benitez
18h 12m
2 stops
MDW11:32 pmChicago Midway
$764
Find similar
Delta
Jan 27
MDW10:35 amChicago Midway
16h 15m
2 stops
SCL5:50 amSantiago Arturo Merino Benitez
Feb 10
SCL11:15 pmSantiago Arturo Merino Benitez
16h 20m
2 stops
MDW12:35 pmChicago Midway
$768
Find similar
Delta
Mar 10
MDW10:35 amChicago Midway
17h 15m
2 stops
SCL5:50 amSantiago Arturo Merino Benitez
Mar 17
SCL6:30 pmSantiago Arturo Merino Benitez
19h 31m
2 stops
MDW12:01 pmChicago Midway
$784
Find similar

Copa Airlines flights from Chicago to Santiago

Our best Copa Airlines deals on Chicago to Santiago flight tickets
Copa Airlines
Oct 13
ORD7:59 amChicago O'Hare Intl
14h 05m
1 stop
SCL12:04 amSantiago Arturo Merino Benitez
Oct 20
SCL4:47 amSantiago Arturo Merino Benitez
21h 34m
1 stop
ORD12:21 amChicago O'Hare Intl
$672
Find similar
Copa Airlines
Sep 26
ORD8:02 amChicago O'Hare Intl
17h 40m
1 stop
SCL3:42 amSantiago Arturo Merino Benitez
Sep 28
SCL3:26 amSantiago Arturo Merino Benitez
22h 55m
1 stop
ORD12:21 amChicago O'Hare Intl
$772
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momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 10/27

10:27 am-10:15 pm

2 stops33h 48m

Santiago Arturo Merino Benitez

Sun 11/9

5:50 am-12:30 pm

2 stops33h 40m

$569

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 10/16

10:27 am-10:15 pm

2 stops33h 48m

Santiago Arturo Merino Benitez

Thu 10/30

10:50 am-9:22 am

1 stop24h 32m

$592

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Sun 11/16

1:35 pm-10:15 pm

2 stops29h 40m

Santiago Arturo Merino Benitez

Fri 11/21

6:00 am-8:57 am

1 stop29h 57m

$595

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 10/20

2:35 pm-5:15 am

1 stop12h 40m

Santiago Arturo Merino Benitez

Tue 11/11

1:35 am-8:20 pm

1 stop21h 45m

$663

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 11/13

10:20 pm-3:20 pm

1 stop14h 00m

Santiago Arturo Merino Benitez

Mon 11/17

7:25 am-8:20 pm

1 stop15h 55m

$664

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 10/13

7:59 am-12:04 am

1 stop14h 05m

Santiago Arturo Merino Benitez

Mon 10/20

4:47 am-12:21 am

1 stop21h 34m

$672

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Sun 9/28

6:30 pm-6:15 pm

2 stops21h 45m

Santiago Arturo Merino Benitez

Wed 10/1

9:40 pm-11:48 am

1 stop16h 08m

$739

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 10/14

12:48 pm-6:50 am

2 stops16h 02m

Santiago Arturo Merino Benitez

Tue 10/21

10:55 pm-11:53 am

2 stops14h 58m

$752

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 11/4

10:40 am-6:35 am

2 stops16h 55m

Santiago Arturo Merino Benitez

Mon 11/10

8:20 am-11:32 pm

2 stops18h 12m

$764

ChicagoSantiago

MDW - SCL

MDWSCL

Chicago Midway

Tue 1/27

10:35 am-5:50 am

2 stops16h 15m

Santiago Arturo Merino Benitez

Tue 2/10

11:15 pm-12:35 pm

2 stops16h 20m

$768

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Chicago to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Chicago to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $704. If you don’t want to visit Santiago in April, then you should wait until August to fly from Chicago, when ticket prices are also cheap, with an average price of $797.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $847. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $992.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Chicago to Santiago when you can find flight prices for as low as $843. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $942 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $869 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Chicago for as low as $673 on momondo.

Can stopping save me money on Chicago to Santiago flights?

You could potentially save up to 36% on your flight if you consider stops on a Chicago to Santiago flight.

How have Chicago to Santiago flight prices changed over time?

As of September 2025, prices for Chicago to Santiago flights are approximately 23% more expensive when compared to flights at the same time last year.

When to book flights from Chicago to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Santiago (CHI to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Santiago

Direct flights

None
There are no direct flights from Chicago to Santiago. There are no popular flight routes from Chicago to Santiago.
Search flight deals

  • How far is Chicago to Santiago Arturo Merino Benitez by plane?

    The distance between Chicago and Santiago Arturo Merino Benitez is about 5311.0 mi. 11h 56m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Chicago to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Chicago to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents you'll need for your trip to Santiago Arturo Merino Benitez Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Chicago to Santiago?

Best airlines flying from Chicago to Santiago

Compare and see reviews for airlines that fly from Chicago to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $511Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights
AviancaPriceFrom $558Free CancellationRating
6.7
2,436 reviews
Search Avianca flights
DeltaPriceFrom $698Free CancellationRating
7.9
7,961 reviews
Search Delta flights
LATAM AirlinesPriceFrom $703Free CancellationRating
7.5
1,849 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $703Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Air CanadaPriceFrom $707Free CancellationRating
7.1
10,000 reviews
Search Air Canada flights
United AirlinesPriceFrom $823Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Santiago?

It is quick and easy to find Chicago to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Chicago to Santiago with flexible booking policies on momondo?

Flights from Chicago to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Santiago?

momondo helps you find the best flight between Chicago and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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