Cheap flights from Chicago to Panama from $121

The month of July is, on average, the cheapest month to fly to Panama from Chicago, with most prices found around $523. If you don’t want to visit Panama in July, then you should wait until June to fly from Chicago, when ticket prices are also cheap, with an average price of $528.

According to our data, Tuesday is the cheapest day to fly to Panama from Chicago. The lowest ticket price found for a Tuesday departure recently was $521. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Panama for around $583.

In the evening is the cheapest time of day to fly from Chicago to Panama when you can find flight prices for as low as $490. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $574 per ticket.

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Chicago - Panama flight prices

You are more likely to see cheaper flights to Panama from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $575 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Chicago for as low as $504 on momondo.

There are 3 cabin classes available to choose from on Chicago to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Avianca and United Airlines are the most popular carriers operating from Chicago to Panama

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama from Chicago according to our data. Copa Airlines is the first choice among our users, with 86% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 5 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Historically, on average around 11% of flights between Chicago and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 127 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights at night have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 10% of their flights experiencing any sort of delay.

The number of flights available between Chicago and Panama is 4 per day as of March 2026. The most frequent departure time is 8:00AM, with 63% of daily flights leaving at noon.

As of March 2026, there are 33 flights per week flying from Chicago to Panama. The most common day of the week flights depart is Mon, with 15% of flights taking off on this day.