Cheap flights from Chicago to Panama from $114

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Panama departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
10:20 pm - 2:00 pm
ORD
-
PTY
14h 40m
1 stop
Avianca Logo
2:55 am - 8:20 pm
PTY
-
ORD
18h 25m
1 stop
$357Avianca
Thu, Feb 26 - Wed, Mar 4
Multiple Airlines Logo
6:40 am - 12:40 am
ORD
-
PTY
17h 00m
2 stops
Multiple Airlines Logo
5:50 pm - 9:20 pm
PTY
-
ORD
27h 30m
1 stop
$381Multiple Airlines
Mon, Feb 23 - Tue, Mar 17
Avianca Logo
10:20 pm - 2:00 pm
ORD
-
PTY
14h 40m
1 stop
Avianca Logo
2:55 pm - 9:20 pm
PTY
-
ORD
30h 25m
1 stop
$382Avianca
Fri, Mar 6 - Sun, Mar 15
Multiple Airlines Logo
6:51 pm - 12:40 am
ORD
-
PTY
28h 49m
2 stops
Multiple Airlines Logo
2:55 am - 8:20 pm
PTY
-
ORD
18h 25m
1 stop
$387Multiple Airlines
Sun, Mar 1 - Fri, Mar 6
Multiple Airlines Logo
10:20 pm - 8:50 am
ORD
-
PTY
9h 30m
1 stop
Multiple Airlines Logo
5:50 pm - 9:39 am
PTY
-
ORD
15h 49m
2 stops
$396Multiple Airlines
Wed, Mar 4 - Mon, Mar 9
Multiple Airlines Logo
10:20 pm - 1:00 am
ORD
-
PTY
25h 40m
1 stop
Multiple Airlines Logo
9:45 am - 9:39 am
PTY
-
ORD
24h 54m
2 stops
$404Multiple Airlines
Fri, Feb 20 - Thu, Feb 26
Copa Airlines Logo
7:34 am - 5:31 pm
ORD
-
DAV
8h 57m
1 stop
Copa Airlines Logo
9:48 am - 12:04 am
DAV
-
ORD
15h 16m
1 stop
$752Copa Airlines
Sun, Mar 1 - Sat, Mar 7
United Airlines Logo
5:30 am - 8:58 am
ORD
-
DAV
27h 28m
2 stops
United Airlines Logo
9:38 am - 10:20 am
DAV
-
ORD
24h 42m
2 stops
$997United Airlines
Sat, May 23 - Wed, May 27
Copa Airlines Logo
8:02 am - 4:26 pm
ORD
-
DAV
8h 24m
1 stop
Copa Airlines Logo
8:31 am - 1:15 am
DAV
-
ORD
16h 44m
1 stop
$1,007Copa Airlines
Fri, Jun 5 - Sun, Jun 14
United Airlines Logo
9:15 am - 9:04 am
ORD
-
DAV
22h 49m
2 stops
United Airlines Logo
9:48 am - 6:46 am
DAV
-
ORD
21h 58m
2 stops
$1,133United Airlines
Sun, Mar 1 - Sat, Mar 7

LATAM Airlines flights from Chicago to Panama

Our best LATAM Airlines deals on Chicago to Panama flight tickets
LATAM Airlines
Apr 29
MDW6:00 amChicago Midway
7h 02m
1 stop
PTY1:02 pmPanama City Tocumen Intl
May 3
PTY2:27 pmPanama City Tocumen Intl
25h 58m
1 stop
MDW4:25 pmChicago Midway
$629
LATAM Airlines
Feb 15
MDW6:00 amChicago Midway
6h 50m
1 stop
PTY1:50 pmPanama City Tocumen Intl
Feb 19
PTY3:15 pmPanama City Tocumen Intl
27h 30m
1 stop
MDW5:45 pmChicago Midway
$768
LATAM Airlines
Feb 14
MDW4:13 pmChicago Midway
20h 37m
1 stop
PTY1:50 pmPanama City Tocumen Intl
Feb 23
PTY3:15 pmPanama City Tocumen Intl
21h 44m
1 stop
MDW11:59 amChicago Midway
$781

Delta flights from Chicago to Panama

Our best Delta deals on Chicago to Panama flight tickets
Delta
Mar 4
MDW6:00 amChicago Midway
6h 50m
1 stop
PTY1:50 pmPanama City Tocumen Intl
Mar 11
PTY2:28 pmPanama City Tocumen Intl
8h 03m
1 stop
MDW10:31 pmChicago Midway
$628
Delta
Mar 2
MDW1:29 pmChicago Midway
23h 21m
2 stops
PTY1:50 pmPanama City Tocumen Intl
Mar 10
PTY2:28 pmPanama City Tocumen Intl
8h 03m
1 stop
MDW10:31 pmChicago Midway
$632
Delta
Mar 7
MDW4:13 pmChicago Midway
19h 50m
1 stop
PTY1:03 pmPanama City Tocumen Intl
Mar 11
PTY2:28 pmPanama City Tocumen Intl
8h 03m
1 stop
MDW10:31 pmChicago Midway
$638

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Chicago to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 2/26

10:20 pm-2:00 pm

1 stop14h 40m

Panama City Tocumen Intl

Wed 3/4

2:55 am-8:20 pm

1 stop18h 25m

$357

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Mon 2/23

6:40 am-12:40 am

2 stops17h 00m

Panama City Tocumen Intl

Tue 3/17

5:50 pm-9:20 pm

1 stop27h 30m

$381

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 3/6

10:20 pm-2:00 pm

1 stop14h 40m

Panama City Tocumen Intl

Sun 3/15

2:55 pm-9:20 pm

1 stop30h 25m

$382

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sun 3/1

6:51 pm-12:40 am

2 stops28h 49m

Panama City Tocumen Intl

Fri 3/6

2:55 am-8:20 pm

1 stop18h 25m

$387

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 3/4

10:20 pm-8:50 am

1 stop9h 30m

Panama City Tocumen Intl

Mon 3/9

5:50 pm-9:39 am

2 stops15h 49m

$396

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 2/20

10:20 pm-1:00 am

1 stop25h 40m

Panama City Tocumen Intl

Thu 2/26

9:45 am-9:39 am

2 stops24h 54m

$404

ChicagoDavid

ORD - DAV

ORDDAV

Chicago O'Hare Intl

Sun 3/1

7:34 am-5:31 pm

1 stop8h 57m

David Enrique Malek

Sat 3/7

9:48 am-12:04 am

1 stop15h 16m

$752

ChicagoDavid

ORD - DAV

ORDDAV

Chicago O'Hare Intl

Sat 5/23

5:30 am-8:58 am

2 stops27h 28m

David Enrique Malek

Wed 5/27

9:38 am-10:20 am

2 stops24h 42m

$997

ChicagoDavid

ORD - DAV

ORDDAV

Chicago O'Hare Intl

Fri 6/5

8:02 am-4:26 pm

1 stop8h 24m

David Enrique Malek

Sun 6/14

8:31 am-1:15 am

1 stop16h 44m

$1,007

ChicagoDavid

ORD - DAV

ORDDAV

Chicago O'Hare Intl

Sun 3/1

9:15 am-9:04 am

2 stops22h 49m

David Enrique Malek

Sat 3/7

9:48 am-6:46 am

2 stops21h 58m

$1,133

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Chicago to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of July is, on average, the cheapest month to fly to Panama from Chicago, with most prices found around $523. If you don’t want to visit Panama in July, then you should wait until September to fly from Chicago, when ticket prices are also cheap, with an average price of $534.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Chicago. The lowest ticket price found for a Tuesday departure recently was $523. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Panama for around $584.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Chicago to Panama when you can find flight prices for as low as $494. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $575 per ticket.

What is the cheapest Chicago to Panama flight route?

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Chicago - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $585 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Chicago for as low as $535 on momondo.

What cabin class options are available on Chicago to Panama flights?

There are 3 cabin classes available to choose from on Chicago to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Panama flights?

You could potentially save up to 81% on your flight if you consider stops on a Chicago to Panama flight.

Cheap Chicago to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Panama

Best Price Found

$180

Fastest flight time

5h 13m

Direct flights

Tue, Wed, Thu, Fri, Sat and Sun

Airports in Panama

21 airports
The best one-way flight to Panama from Chicago in the past 72 hours is $180. The best round-trip flight deal from Chicago to Panama found on momondo in the last 72 hours is $355.
The fastest flight from Chicago to Panama takes 5h 13m
Direct flights go from Chicago to Panama on Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There are 21 airports in Panama. From Chicago there are direct flights to Panama City Tocumen Intl (PTY).
  • When did momondo last update prices for flights from Chicago to Panama?

    Prices for flights from Chicago to Panama refresh daily.

  • How many operators does momondo search for flights from Chicago to Panama?

  • How old do you have to be to fly from Chicago to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Chicago to Panama?

Best airlines flying from Chicago to Panama

Compare and see reviews for airlines that fly from Chicago to Panama with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $251Free CancellationRating
6.5
2,498 reviews
Search Avianca flights
Copa AirlinesPriceFrom $462Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
DeltaPriceFrom $479Free CancellationRating
7.9
8,139 reviews
Search Delta flights
United AirlinesPriceFrom $479Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights
American AirlinesPriceFrom $563Free CancellationRating
7.2
11,218 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama from Chicago.

Can I find flights from Chicago to Panama with flexible booking policies on momondo?

Flights from Chicago to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Chicago.

I’m not ready to book a flight from Chicago to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Thu 3/5
Thu 3/12

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