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Cheap flights from Charlotte to Panama from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charlotte to Panama departing on 12/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Charlotte to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
6:00 am - 1:59 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
7h 59m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
3:30 pm - 8:51 amPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
17h 21m1 stop Atlanta Hartsfield-Jackson
$516JetBlue
Fri, Nov 6 - Mon, Nov 9
Delta Logo
5:30 am - 2:05 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
8h 35m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 11:54 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 24m1 stop Atlanta Hartsfield-Jackson
$559Delta
Thu, Dec 10 - Mon, Dec 14
American Airlines Logo
6:00 am - 1:02 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
8h 02m1 stop Miami
American Airlines Logo
2:02 pm - 11:49 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 47m1 stop Miami
$579American Airlines
Tue, Oct 6 - Tue, Oct 20
American Airlines Logo
6:00 am - 1:02 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
8h 02m1 stop Miami
American Airlines Logo
3:13 pm - 11:59 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 46m1 stop Miami
$579American Airlines
Tue, Oct 20 - Tue, Nov 3
United Airlines Logo
11:00 am - 7:31 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
9h 31m1 stop Newark
United Airlines Logo
8:55 am - 9:59 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
13h 04m1 stop Houston George Bush Intcntl
$579United Airlines
Wed, Oct 21 - Wed, Nov 18
United Airlines Logo
11:00 am - 7:31 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
9h 31m1 stop Newark
United Airlines Logo
8:55 am - 9:59 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
13h 04m1 stop Houston George Bush Intcntl
$579United Airlines
Tue, Oct 20 - Tue, Nov 3
Delta Logo
6:40 am - 2:05 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
7h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 11:54 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 24m1 stop Atlanta Hartsfield-Jackson
$579Delta
Thu, Dec 10 - Mon, Dec 14
Delta Logo
5:30 am - 2:05 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
8h 35m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 11:54 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 24m1 stop Atlanta Hartsfield-Jackson
$579Delta
Thu, Dec 10 - Mon, Dec 14
Multiple Airlines Logo
11:27 am - 1:55 amCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
15h 28m3 stops Miami Managua Augusto C Sandino San Salvador El Salvador Intl
Multiple Airlines Logo
5:30 am - 9:14 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
14h 44m3 stops San Salvador El Salvador Intl Managua Augusto C Sandino Miami
$695Multiple Airlines
Thu, Sep 10 - Thu, Sep 17
Multiple Airlines Logo
11:27 am - 1:55 amCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
15h 28m3 stops Miami Managua Augusto C Sandino San Salvador El Salvador Intl
Multiple Airlines Logo
4:25 am - 9:14 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
15h 49m2 stops Bogotá El Dorado Miami
$794Multiple Airlines
Thu, Sep 10 - Thu, Sep 17

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American Airlines flights from Charlotte to Panama

Our best American Airlines deals on Charlotte to Panama flight tickets
American Airlines
Oct 12
CLT10:44 pmCharlotte Douglas
15h 18m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Oct 16
PTY2:02 pmPanama City Tocumen Intl
17h 22m
1 stop
CLT8:24 amCharlotte Douglas
$579
American Airlines
Oct 12
CLT10:44 pmCharlotte Douglas
15h 18m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Oct 16
PTY2:02 pmPanama City Tocumen Intl
15h 25m
2 stops
CLT6:27 amCharlotte Douglas
$583
American Airlines
Oct 4
CLT7:05 amCharlotte Douglas
6h 11m
1 stop
PTY12:16 pmPanama City Tocumen Intl
Oct 6
PTY2:02 pmPanama City Tocumen Intl
17h 22m
1 stop
CLT8:24 amCharlotte Douglas
$609

United Airlines flights from Charlotte to Panama

Our best United Airlines deals on Charlotte to Panama flight tickets
United Airlines
Oct 5
CLT11:00 amCharlotte Douglas
9h 31m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Oct 7
PTY9:45 amPanama City Tocumen Intl
10h 30m
1 stop
CLT9:15 pmCharlotte Douglas
$599
United Airlines
Oct 5
CLT6:00 amCharlotte Douglas
14h 31m
2 stops
PTY7:31 pmPanama City Tocumen Intl
Oct 7
PTY9:45 amPanama City Tocumen Intl
22h 59m
2 stops
CLT9:44 amCharlotte Douglas
$603
United Airlines
Oct 12
CLT10:25 amCharlotte Douglas
10h 06m
2 stops
PTY7:31 pmPanama City Tocumen Intl
Oct 16
PTY3:30 pmPanama City Tocumen Intl
21h 50m
2 stops
CLT2:20 pmCharlotte Douglas
$613

momondo Fare Finder

 
Customize your flight search to find flights from Charlotte to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Charlotte to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Fri 11/6

6:00 am-1:59 pm

1 stop7h 59m

Panama City Tocumen Intl

Mon 11/9

3:30 pm-8:51 am

1 stop17h 21m

$516

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

5:30 am-2:05 pm

1 stop8h 35m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-11:54 pm

1 stop8h 24m

$559

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Tue 10/6

6:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Tue 10/20

2:02 pm-11:49 pm

1 stop8h 47m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Tue 10/20

6:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Tue 11/3

3:13 pm-11:59 pm

1 stop8h 46m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Wed 10/21

11:00 am-7:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Wed 11/18

8:55 am-9:59 pm

1 stop13h 04m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Tue 10/20

11:00 am-7:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Tue 11/3

8:55 am-9:59 pm

1 stop13h 04m

$579
Quickest round-trip

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

6:40 am-2:05 pm

1 stop7h 25m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-11:54 pm

1 stop8h 24m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

5:30 am-2:05 pm

1 stop8h 35m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-11:54 pm

1 stop8h 24m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 9/10

11:27 am-1:55 am

3 stops15h 28m

Panama City Tocumen Intl

Thu 9/17

5:30 am-9:14 pm

3 stops14h 44m

$695

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 9/10

11:27 am-1:55 am

3 stops15h 28m

Panama City Tocumen Intl

Thu 9/17

4:25 am-9:14 pm

2 stops15h 49m

$794

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Charlotte to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from Charlotte, with most prices found around $541. If you don’t want to visit Panama in April, then you should wait until February to fly from Charlotte, when ticket prices are also cheap, with an average price of $567.

How far in advance should I book a flight from Charlotte to Panama?

You are more likely to see cheaper flights to Panama from Charlotte when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $642 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Charlotte for as low as $520 on momondo.

Can stopping save me money on Charlotte to Panama flights?

You could potentially save up to 2% on your flight if you consider stops on a Charlotte to Panama flight.

Cheap Charlotte to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charlotte to Panama

Best Price Found

$252

Fastest flight time

7h 25m

Direct flights

None
The best one-way flight to Panama from Charlotte in the past 72 hours is $252. The best round-trip flight deal from Charlotte to Panama found on momondo in the last 72 hours is $516.
The fastest flight from Charlotte to Panama takes 7h 25m
There are no direct flights from Charlotte to Panama. There are no popular flight routes from Charlotte to Panama.
Search flight deals

Frequently asked questions about flying from Charlotte to Panama

  • When did momondo last update prices for flights from Charlotte Douglas Airport to Panama?

    Prices for flights from Charlotte Douglas Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Charlotte Douglas Airport to Panama?

  • How old do you have to be to fly from Charlotte Douglas Airport to Panama?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Charlotte Douglas Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Charlotte to Panama

Compare and see reviews for airlines that fly from Charlotte to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $444Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights
United AirlinesPriceFrom $467Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights
DeltaPriceFrom $487Free CancellationRating
7.8
8,503 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Charlotte to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charlotte to Panama for you.

Can I find flights from Charlotte to Panama with flexible booking policies on momondo?

Flights from Charlotte to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charlotte to Panama?

momondo helps you find the best flight between Charlotte and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Charlotte to Panama right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charlotte to Panama flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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