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Cheap flights from Charlotte to Panama from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charlotte to Panama departing on 12/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:45 pm - 1:47 pmCLT-PTY
16h 02m1 stop
American Airlines Logo
2:50 pm - 7:51 amPTY-CLT
17h 01m1 stop
$400American Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
American Airlines Logo
10:36 pm - 1:47 pmCLT-PTY
15h 11m2 stops
American Airlines Logo
4:43 pm - 7:51 amPTY-CLT
15h 08m1 stop
$404American Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
American Airlines Logo
7:55 am - 3:38 pmCLT-PTY
7h 43m1 stop
American Airlines Logo
2:27 pm - 10:47 pmPTY-CLT
8h 20m1 stop
$406American Airlines
Find Deal
Thu, Jan 29 - Mon, Feb 2
American Airlines Logo
8:41 am - 3:38 pmCLT-PTY
6h 57m1 stop
American Airlines Logo
4:50 pm - 7:31 amPTY-CLT
14h 41m2 stops
$410American Airlines
Find Deal
Thu, Jan 29 - Mon, Feb 2
Delta Logo
9:54 am - 2:02 pmCLT-PTY
28h 08m1 stop
Delta Logo
3:27 pm - 8:42 amPTY-CLT
17h 15m1 stop
$412Delta
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Tue, Feb 17 - Thu, Feb 26
Multiple Airlines Logo
9:38 pm - 2:00 pmCLT-PTY
16h 22m2 stops
Multiple Airlines Logo
5:50 pm - 1:00 pmPTY-CLT
19h 10m2 stops
$429Multiple Airlines
Find Deal
Fri, Nov 14 - Tue, Nov 18
United Airlines Logo
6:33 am - 2:45 pmCLT-PTY
8h 12m1 stop
United Airlines Logo
11:35 am - 9:57 pmPTY-CLT
10h 22m1 stop
$437United Airlines
Find Deal
Mon, Feb 16 - Fri, Feb 20
Delta Logo
9:54 am - 2:02 pmCLT-PTY
28h 08m1 stop
Delta Logo
3:27 pm - 8:42 amPTY-CLT
17h 15m1 stop
$443Delta
Find Deal
Tue, Feb 17 - Tue, Mar 3
United Airlines Logo
11:15 am - 8:02 pmCLT-PTY
8h 47m1 stop
United Airlines Logo
4:41 pm - 10:45 amPTY-CLT
18h 04m1 stop
$446United Airlines
Find Deal
Sat, Jan 17 - Mon, Jan 19
Multiple Airlines Logo
8:52 pm - 8:06 amCLT-PTY
11h 14m1 stop
Multiple Airlines Logo
6:34 pm - 9:18 amPTY-CLT
14h 44m1 stop
$450Multiple Airlines
Find Deal
Sun, Nov 23 - Thu, Nov 27

American Airlines flights from Charlotte to Panama

Our best American Airlines deals on Charlotte to Panama flight tickets
American Airlines
Dec 2
CLT9:45 pmCharlotte Douglas
16h 02m
1 stop
PTY1:47 pmPanama City Tocumen Intl
Dec 9
PTY2:50 pmPanama City Tocumen Intl
17h 01m
1 stop
CLT7:51 amCharlotte Douglas
$400
Find similar
American Airlines
Dec 2
CLT10:36 pmCharlotte Douglas
15h 11m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 9
PTY4:43 pmPanama City Tocumen Intl
15h 08m
1 stop
CLT7:51 amCharlotte Douglas
$404
Find similar
American Airlines
Jan 29
CLT7:55 amCharlotte Douglas
7h 43m
1 stop
PTY3:38 pmPanama City Tocumen Intl
Feb 2
PTY2:27 pmPanama City Tocumen Intl
8h 20m
1 stop
CLT10:47 pmCharlotte Douglas
$406
Find similar

United Airlines flights from Charlotte to Panama

Our best United Airlines deals on Charlotte to Panama flight tickets
United Airlines
Feb 16
CLT6:33 amCharlotte Douglas
8h 12m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Feb 20
PTY11:35 amPanama City Tocumen Intl
10h 22m
1 stop
CLT9:57 pmCharlotte Douglas
$437
Find similar
United Airlines
Jan 17
CLT11:15 amCharlotte Douglas
8h 47m
1 stop
PTY8:02 pmPanama City Tocumen Intl
Jan 19
PTY4:41 pmPanama City Tocumen Intl
18h 04m
1 stop
CLT10:45 amCharlotte Douglas
$446
Find similar
United Airlines
Feb 16
CLT6:33 amCharlotte Douglas
13h 05m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Mar 2
PTY8:55 amPanama City Tocumen Intl
13h 02m
1 stop
CLT9:57 pmCharlotte Douglas
$468
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charlotte to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Charlotte to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 12/2

9:45 pm-1:47 pm

1 stop16h 02m

Panama City Tocumen Intl

Tue 12/9

2:50 pm-7:51 am

1 stop17h 01m

$400

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 12/2

10:36 pm-1:47 pm

2 stops15h 11m

Panama City Tocumen Intl

Tue 12/9

4:43 pm-7:51 am

1 stop15h 08m

$404

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 1/29

7:55 am-3:38 pm

1 stop7h 43m

Panama City Tocumen Intl

Mon 2/2

2:27 pm-10:47 pm

1 stop8h 20m

$406

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 1/29

8:41 am-3:38 pm

1 stop6h 57m

Panama City Tocumen Intl

Mon 2/2

4:50 pm-7:31 am

2 stops14h 41m

$410

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

9:54 am-2:02 pm

1 stop28h 08m

Panama City Tocumen Intl

Thu 2/26

3:27 pm-8:42 am

1 stop17h 15m

$412

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 11/14

9:38 pm-2:00 pm

2 stops16h 22m

Panama City Tocumen Intl

Tue 11/18

5:50 pm-1:00 pm

2 stops19h 10m

$429

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 2/16

6:33 am-2:45 pm

1 stop8h 12m

Panama City Tocumen Intl

Fri 2/20

11:35 am-9:57 pm

1 stop10h 22m

$437

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

9:54 am-2:02 pm

1 stop28h 08m

Panama City Tocumen Intl

Tue 3/3

3:27 pm-8:42 am

1 stop17h 15m

$443

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 1/17

11:15 am-8:02 pm

1 stop8h 47m

Panama City Tocumen Intl

Mon 1/19

4:41 pm-10:45 am

1 stop18h 04m

$446

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 11/23

8:52 pm-8:06 am

1 stop11h 14m

Panama City Tocumen Intl

Thu 11/27

6:34 pm-9:18 am

1 stop14h 44m

$450

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Charlotte to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Charlotte, with most prices found around $496. If you don’t want to visit Panama in September, then you should wait until May to fly from Charlotte, when ticket prices are also cheap, with an average price of $507.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Charlotte. The lowest ticket price found for a Wednesday departure recently was $502. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Charlotte to Panama for around $650.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Charlotte to Panama when you can find flight prices for as low as $478. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $844 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Charlotte when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $562 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Charlotte for as low as $457 on momondo.

Cheap Charlotte to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charlotte to Panama

Direct flights

None
There are no direct flights from Charlotte to Panama. There are no popular flight routes from Charlotte to Panama.
Search flight deals

  • When did momondo last update prices for flights from Charlotte Douglas Airport to Panama?

    Prices for flights from Charlotte Douglas Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Charlotte Douglas Airport to Panama?

  • How old do you have to be to fly from Charlotte Douglas Airport to Panama?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Charlotte Douglas Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Charlotte to Panama

Compare and see reviews for airlines that fly from Charlotte to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $435Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
United AirlinesPriceFrom $436Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights
DeltaPriceFrom $466Free CancellationRating
7.9
8,003 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Charlotte to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charlotte to Panama for you.

Can I find flights from Charlotte to Panama with flexible booking policies on momondo?

Flights from Charlotte to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charlotte to Panama?

momondo helps you find the best flight between Charlotte and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Charlotte to Panama right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charlotte to Panama flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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