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Cheap flights from Charleston to Santo Domingo from $207

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:05 am - 6:06 pmCHS  Charleston-SDQ Santo Domingo Las Americas
12h 01m1 stop New York John F Kennedy Intl
Delta Logo
2:57 pm - 11:59 pmSDQ  Santo Domingo Las Americas-CHS Charleston
9h 02m1 stop Atlanta Hartsfield-Jackson
$448Delta
Thu, Oct 15 - Sun, Oct 18
American Airlines Logo
6:00 am - 1:33 pmCHS  Charleston-SDQ Santo Domingo Las Americas
7h 33m1 stop Miami
American Airlines Logo
1:35 pm - 11:56 pmSDQ  Santo Domingo Las Americas-CHS Charleston
10h 21m1 stop Philadelphia
$448American Airlines
Tue, Oct 13 - Mon, Oct 19
American Airlines Logo
6:44 pm - 12:35 pmCHS  Charleston-SDQ Santo Domingo Las Americas
17h 51m1 stop Philadelphia
American Airlines Logo
1:35 pm - 11:56 pmSDQ  Santo Domingo Las Americas-CHS Charleston
10h 21m1 stop Philadelphia
$448American Airlines
Sat, Oct 17 - Mon, Oct 19
American Airlines Logo
11:12 am - 8:50 pmCHS  Charleston-SDQ Santo Domingo Las Americas
9h 38m1 stop Miami
American Airlines Logo
1:35 pm - 11:56 pmSDQ  Santo Domingo Las Americas-CHS Charleston
10h 21m1 stop Philadelphia
$448American Airlines
Sat, Oct 17 - Mon, Oct 19
Delta Logo
5:10 am - 1:28 pmCHS  Charleston-SDQ Santo Domingo Las Americas
8h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 11:59 pmSDQ  Santo Domingo Las Americas-CHS Charleston
9h 06m1 stop Atlanta Hartsfield-Jackson
$601Delta
Mon, Sep 7 - Mon, Sep 28
United Airlines Logo
3:35 pm - 1:41 pmCHS  Charleston-SDQ Santo Domingo Las Americas
21h 06m1 stop Newark
United Airlines Logo
4:18 pm - 11:59 pmSDQ  Santo Domingo Las Americas-CHS Charleston
8h 41m1 stop Newark
$632United Airlines
Mon, Nov 9 - Thu, Nov 12
United Airlines Logo
7:04 pm - 1:41 pmCHS  Charleston-SDQ Santo Domingo Las Americas
17h 37m1 stop Newark
United Airlines Logo
2:53 pm - 11:59 pmSDQ  Santo Domingo Las Americas-CHS Charleston
10h 06m1 stop Newark
$678United Airlines
Mon, Nov 9 - Thu, Nov 12
Delta Logo
6:15 am - 1:28 pmCHS  Charleston-SDQ Santo Domingo Las Americas
7h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 11:59 pmSDQ  Santo Domingo Las Americas-CHS Charleston
9h 06m1 stop Atlanta Hartsfield-Jackson
$684Delta
Mon, Sep 7 - Mon, Sep 28
Multiple Airlines Logo
2:13 pm - 7:04 pmCHS  Charleston-SDQ Santo Domingo Las Americas
27h 51m1 stop Orlando
Multiple Airlines Logo
3:30 pm - 8:38 amSDQ  Santo Domingo Las Americas-CHS Charleston
18h 08m2 stops San Juan Luis Munoz Marin Intl Orlando
$1,204Multiple Airlines
Thu, Dec 24 - Sat, Jan 2
Delta Logo
12:15 pm - 2:20 amCHS  Charleston-SDQ Santo Domingo Las Americas
13h 05m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl
Delta Logo
6:50 am - 6:03 pmSDQ  Santo Domingo Las Americas-CHS Charleston
12h 13m2 stops New York John F Kennedy Intl Detroit Metropolitan Wayne County
$1,601Delta
Thu, Dec 24 - Sat, Jan 2

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United Airlines flights from Charleston to Santo Domingo

Our best United Airlines deals on Charleston to Santo Domingo flight tickets
United Airlines
Nov 9
CHS7:04 pmCharleston
17h 37m
1 stop
SDQ1:41 pmSanto Domingo Las Americas
Nov 12
SDQ2:53 pmSanto Domingo Las Americas
10h 06m
1 stop
CHS11:59 pmCharleston
$678
United Airlines
Aug 15
CHS3:20 pmCharleston
7h 26m
1 stop
SDQ10:46 pmSanto Domingo Las Americas
Aug 28
SDQ6:00 amSanto Domingo Las Americas
17h 59m
1 stop
CHS11:59 pmCharleston
$953
United Airlines
Aug 18
CHS3:20 pmCharleston
7h 26m
1 stop
SDQ10:46 pmSanto Domingo Las Americas
Aug 23
SDQ6:00 amSanto Domingo Las Americas
27h 13m
1 stop
CHS9:13 amCharleston
$995

American Airlines flights from Charleston to Santo Domingo

Our best American Airlines deals on Charleston to Santo Domingo flight tickets
American Airlines
Oct 17
CHS7:00 amCharleston
13h 50m
2 stops
SDQ8:50 pmSanto Domingo Las Americas
Oct 19
SDQ7:00 amSanto Domingo Las Americas
10h 54m
2 stops
CHS5:54 pmCharleston
$453
American Airlines
Sep 11
CHS6:39 pmCharleston
14h 42m
2 stops
SDQ9:21 amSanto Domingo Las Americas
Sep 13
SDQ10:21 amSanto Domingo Las Americas
13h 25m
2 stops
CHS11:46 pmCharleston
$458
American Airlines
Aug 26
CHS6:00 amCharleston
7h 22m
1 stop
SDQ1:22 pmSanto Domingo Las Americas
Sep 9
SDQ9:30 amSanto Domingo Las Americas
6h 17m
1 stop
CHS3:47 pmCharleston
$463

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Thu 10/15

6:05 am-6:06 pm

1 stop12h 01m

Santo Domingo Las Americas

Sun 10/18

2:57 pm-11:59 pm

1 stop9h 02m

$448

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Tue 10/13

6:00 am-1:33 pm

1 stop7h 33m

Santo Domingo Las Americas

Mon 10/19

1:35 pm-11:56 pm

1 stop10h 21m

$448

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Sat 10/17

6:44 pm-12:35 pm

1 stop17h 51m

Santo Domingo Las Americas

Mon 10/19

1:35 pm-11:56 pm

1 stop10h 21m

$448

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Sat 10/17

11:12 am-8:50 pm

1 stop9h 38m

Santo Domingo Las Americas

Mon 10/19

1:35 pm-11:56 pm

1 stop10h 21m

$448

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Mon 9/7

5:10 am-1:28 pm

1 stop8h 18m

Santo Domingo Las Americas

Mon 9/28

2:53 pm-11:59 pm

1 stop9h 06m

$601

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Mon 11/9

3:35 pm-1:41 pm

1 stop21h 06m

Santo Domingo Las Americas

Thu 11/12

4:18 pm-11:59 pm

1 stop8h 41m

$632

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Mon 11/9

7:04 pm-1:41 pm

1 stop17h 37m

Santo Domingo Las Americas

Thu 11/12

2:53 pm-11:59 pm

1 stop10h 06m

$678
Quickest round-trip

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Mon 9/7

6:15 am-1:28 pm

1 stop7h 13m

Santo Domingo Las Americas

Mon 9/28

2:53 pm-11:59 pm

1 stop9h 06m

$684

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Thu 12/24

2:13 pm-7:04 pm

1 stop27h 51m

Santo Domingo Las Americas

Sat 1/2

3:30 pm-8:38 am

2 stops18h 08m

$1,204

CharlestonSanto Domingo

CHS Charleston - SDQ Santo Domingo Las Americas

CHSSDQ

Charleston

Thu 12/24

12:15 pm-2:20 am

2 stops13h 05m

Santo Domingo Las Americas

Sat 1/2

6:50 am-6:03 pm

2 stops12h 13m

$1,601

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in February, then you should wait until November to fly from Charleston, when ticket prices are also cheap, with an average price of $380.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 10% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Fastest flight time

6h 45m

Direct flights

None
The fastest flight from Charleston to Santo Domingo takes 6h 45m
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

Frequently asked questions about flying from Charleston to Santo Domingo

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 6h 45m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $321Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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