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Cheap flights from Charleston to Santo Domingo from $177

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 5/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 6:34 pm
CHS
-
SDQ
12h 34m
1 stop
Delta Logo
6:05 am - 5:06 pm
SDQ
-
CHS
11h 01m
1 stop
$385Delta
Wed, Apr 22 - Sat, Apr 25
JetBlue Logo
5:59 pm - 2:27 am
CHS
-
SDQ
8h 28m
1 stop
JetBlue Logo
5:50 am - 4:57 pm
SDQ
-
CHS
11h 07m
1 stop
$388JetBlue
Fri, May 15 - Sun, May 17
Delta Logo
5:20 am - 6:34 pm
CHS
-
SDQ
13h 14m
2 stops
Delta Logo
6:05 am - 5:06 pm
SDQ
-
CHS
11h 01m
1 stop
$389Delta
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
6:00 am - 1:18 pm
CHS
-
SDQ
7h 18m
1 stop
American Airlines Logo
4:00 pm - 10:34 am
SDQ
-
CHS
18h 34m
1 stop
$393American Airlines
Wed, Apr 22 - Mon, Apr 27
American Airlines Logo
8:21 pm - 1:18 pm
CHS
-
SDQ
16h 57m
2 stops
American Airlines Logo
4:00 pm - 10:34 am
SDQ
-
CHS
18h 34m
1 stop
$397American Airlines
Wed, Apr 22 - Mon, Apr 27
American Airlines Logo
8:09 pm - 9:20 am
CHS
-
SDQ
13h 11m
1 stop
American Airlines Logo
6:00 am - 12:24 am
SDQ
-
CHS
18h 24m
1 stop
$398American Airlines
Thu, Apr 30 - Sun, May 3
American Airlines Logo
8:09 pm - 2:59 pm
CHS
-
SDQ
18h 50m
1 stop
American Airlines Logo
4:00 pm - 10:34 am
SDQ
-
CHS
18h 34m
1 stop
$400American Airlines
Wed, Apr 22 - Mon, Apr 27
American Airlines Logo
7:13 pm - 9:20 am
CHS
-
SDQ
14h 07m
2 stops
American Airlines Logo
6:00 am - 12:24 am
SDQ
-
CHS
18h 24m
1 stop
$402American Airlines
Thu, Apr 30 - Sun, May 3
Delta Logo
5:20 am - 6:34 pm
CHS
-
SDQ
13h 14m
2 stops
Delta Logo
6:05 am - 8:41 pm
SDQ
-
CHS
14h 36m
2 stops
$426Delta
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
7:54 pm - 9:25 am
CHS
-
SDQ
13h 31m
1 stop
American Airlines Logo
10:25 am - 12:16 am
SDQ
-
CHS
13h 51m
1 stop
$432American Airlines
Thu, Aug 20 - Mon, Aug 24

Delta flights from Charleston to Santo Domingo

Our best Delta deals on Charleston to Santo Domingo flight tickets
Delta
Apr 22
CHS6:00 amCharleston
12h 34m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
Apr 25
SDQ6:05 amSanto Domingo Las Americas
11h 01m
1 stop
CHS5:06 pmCharleston
$385
Delta
Apr 22
CHS5:20 amCharleston
13h 14m
2 stops
SDQ6:34 pmSanto Domingo Las Americas
Apr 25
SDQ6:05 amSanto Domingo Las Americas
11h 01m
1 stop
CHS5:06 pmCharleston
$389
Delta
Apr 22
CHS5:20 amCharleston
13h 14m
2 stops
SDQ6:34 pmSanto Domingo Las Americas
Apr 25
SDQ6:05 amSanto Domingo Las Americas
11h 01m
1 stop
CHS5:06 pmCharleston
$409

JetBlue flights from Charleston to Santo Domingo

Our best JetBlue deals on Charleston to Santo Domingo flight tickets
JetBlue
Apr 17
CHS11:18 amCharleston
7h 02m
1 stop
SDQ6:20 pmSanto Domingo Las Americas
Apr 26
SDQ2:42 amSanto Domingo Las Americas
13h 50m
1 stop
CHS4:32 pmCharleston
$388
JetBlue
Apr 11
CHS10:00 amCharleston
8h 31m
1 stop
SDQ6:31 pmSanto Domingo Las Americas
Apr 13
SDQ3:20 amSanto Domingo Las Americas
12h 17m
1 stop
CHS3:37 pmCharleston
$486
JetBlue
May 15
CHS8:12 pmCharleston
24h 46m
2 stops
SDQ8:58 pmSanto Domingo Las Americas
May 17
SDQ5:50 amSanto Domingo Las Americas
11h 07m
1 stop
CHS4:57 pmCharleston
$503

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

6:00 am-6:34 pm

1 stop12h 34m

Santo Domingo Las Americas

Sat 4/25

6:05 am-5:06 pm

1 stop11h 01m

$385
Quickest round-trip

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 5/15

5:59 pm-2:27 am

1 stop8h 28m

Santo Domingo Las Americas

Sun 5/17

5:50 am-4:57 pm

1 stop11h 07m

$388

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

5:20 am-6:34 pm

2 stops13h 14m

Santo Domingo Las Americas

Sat 4/25

6:05 am-5:06 pm

1 stop11h 01m

$389

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

6:00 am-1:18 pm

1 stop7h 18m

Santo Domingo Las Americas

Mon 4/27

4:00 pm-10:34 am

1 stop18h 34m

$393

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

8:21 pm-1:18 pm

2 stops16h 57m

Santo Domingo Las Americas

Mon 4/27

4:00 pm-10:34 am

1 stop18h 34m

$397

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/30

8:09 pm-9:20 am

1 stop13h 11m

Santo Domingo Las Americas

Sun 5/3

6:00 am-12:24 am

1 stop18h 24m

$398

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

8:09 pm-2:59 pm

1 stop18h 50m

Santo Domingo Las Americas

Mon 4/27

4:00 pm-10:34 am

1 stop18h 34m

$400

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/30

7:13 pm-9:20 am

2 stops14h 07m

Santo Domingo Las Americas

Sun 5/3

6:00 am-12:24 am

1 stop18h 24m

$402

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

5:20 am-6:34 pm

2 stops13h 14m

Santo Domingo Las Americas

Sat 4/25

6:05 am-8:41 pm

2 stops14h 36m

$426

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 8/20

7:54 pm-9:25 am

1 stop13h 31m

Santo Domingo Las Americas

Mon 8/24

10:25 am-12:16 am

1 stop13h 51m

$432

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from Charleston, when ticket prices are also cheap, with an average price of $398.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 30% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Fastest flight time

7h 10m

Direct flights

None
The fastest flight from Charleston to Santo Domingo takes 7h 10m
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 7h 10m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $321Free CancellationRating
7.9
8,320 reviews
Search Delta flights
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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