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Cheap flights from Charleston to Santo Domingo from $218

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 5/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:09 pm - 9:24 am
CHS
-
SDQ
13h 15m
1 stop
American Airlines Logo
7:35 pm - 10:22 am
SDQ
-
CHS
14h 47m
1 stop
$460American Airlines
Wed, May 27 - Wed, Jul 1
Delta Logo
5:15 am - 6:01 pm
CHS
-
SDQ
12h 46m
2 stops
Delta Logo
6:06 am - 4:54 pm
SDQ
-
CHS
10h 48m
1 stop
$465Delta
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
6:42 pm - 12:45 pm
CHS
-
SDQ
18h 03m
1 stop
American Airlines Logo
7:00 am - 6:51 pm
SDQ
-
CHS
11h 51m
1 stop
$468American Airlines
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
8:09 pm - 9:24 am
CHS
-
SDQ
13h 15m
1 stop
American Airlines Logo
7:35 pm - 9:17 am
SDQ
-
CHS
13h 42m
1 stop
$490American Airlines
Fri, May 22 - Sun, May 24
Delta Logo
6:00 am - 6:01 pm
CHS
-
SDQ
12h 01m
1 stop
Delta Logo
6:06 am - 4:54 pm
SDQ
-
CHS
10h 48m
1 stop
$513Delta
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
11:14 am - 10:55 pm
CHS
-
SDQ
11h 41m
1 stop
American Airlines Logo
2:25 pm - 10:07 am
SDQ
-
CHS
19h 42m
2 stops
$518American Airlines
Sat, May 16 - Wed, May 20
American Airlines Logo
6:06 am - 12:45 pm
CHS
-
SDQ
6h 39m
1 stop
American Airlines Logo
7:35 pm - 7:30 pm
SDQ
-
CHS
23h 55m
1 stop
$522American Airlines
Fri, Jun 12 - Wed, Jun 17
American Airlines Logo
1:51 pm - 10:55 pm
CHS
-
SDQ
9h 04m
2 stops
American Airlines Logo
7:35 pm - 7:30 pm
SDQ
-
CHS
23h 55m
1 stop
$526American Airlines
Fri, Jun 12 - Wed, Jun 17
American Airlines Logo
11:04 am - 9:25 pm
CHS
-
SDQ
10h 21m
1 stop
American Airlines Logo
7:40 pm - 10:22 am
SDQ
-
CHS
14h 42m
1 stop
$535American Airlines
Fri, Jul 3 - Wed, Jul 8
American Airlines Logo
7:05 am - 6:40 pm
CHS
-
SDQ
11h 35m
2 stops
American Airlines Logo
1:57 pm - 11:55 pm
SDQ
-
CHS
9h 58m
1 stop
$540American Airlines
Fri, Jul 3 - Wed, Jul 8

JetBlue flights from Charleston to Santo Domingo

Our best JetBlue deals on Charleston to Santo Domingo flight tickets
JetBlue
Aug 20
CHS5:27 pmCharleston
6h 32m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Aug 24
SDQ5:01 amSanto Domingo Las Americas
11h 46m
1 stop
CHS4:47 pmCharleston
$363
JetBlue
Sep 1
CHS5:27 pmCharleston
6h 32m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Sep 2
SDQ5:01 amSanto Domingo Las Americas
11h 30m
1 stop
CHS4:31 pmCharleston
$368
JetBlue
Sep 29
CHS7:05 pmCharleston
4h 54m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Oct 3
SDQ7:22 pmSanto Domingo Las Americas
14h 53m
1 stop
CHS10:15 amCharleston
$470

American Airlines flights from Charleston to Santo Domingo

Our best American Airlines deals on Charleston to Santo Domingo flight tickets
American Airlines
May 27
CHS8:09 pmCharleston
13h 15m
1 stop
SDQ9:24 amSanto Domingo Las Americas
Jul 1
SDQ7:35 pmSanto Domingo Las Americas
14h 47m
1 stop
CHS10:22 amCharleston
$460
American Airlines
Jun 2
CHS6:42 pmCharleston
18h 03m
1 stop
SDQ12:45 pmSanto Domingo Las Americas
Jun 9
SDQ7:00 amSanto Domingo Las Americas
11h 51m
1 stop
CHS6:51 pmCharleston
$468
American Airlines
May 22
CHS8:09 pmCharleston
13h 15m
1 stop
SDQ9:24 amSanto Domingo Las Americas
May 24
SDQ7:35 pmSanto Domingo Las Americas
13h 42m
1 stop
CHS9:17 amCharleston
$490

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 5/27

8:09 pm-9:24 am

1 stop13h 15m

Santo Domingo Las Americas

Wed 7/1

7:35 pm-10:22 am

1 stop14h 47m

$460

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/2

5:15 am-6:01 pm

2 stops12h 46m

Santo Domingo Las Americas

Tue 6/9

6:06 am-4:54 pm

1 stop10h 48m

$465

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/2

6:42 pm-12:45 pm

1 stop18h 03m

Santo Domingo Las Americas

Tue 6/9

7:00 am-6:51 pm

1 stop11h 51m

$468

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 5/22

8:09 pm-9:24 am

1 stop13h 15m

Santo Domingo Las Americas

Sun 5/24

7:35 pm-9:17 am

1 stop13h 42m

$490

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/2

6:00 am-6:01 pm

1 stop12h 01m

Santo Domingo Las Americas

Tue 6/9

6:06 am-4:54 pm

1 stop10h 48m

$513

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/16

11:14 am-10:55 pm

1 stop11h 41m

Santo Domingo Las Americas

Wed 5/20

2:25 pm-10:07 am

2 stops19h 42m

$518

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 6/12

6:06 am-12:45 pm

1 stop6h 39m

Santo Domingo Las Americas

Wed 6/17

7:35 pm-7:30 pm

1 stop23h 55m

$522

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 6/12

1:51 pm-10:55 pm

2 stops9h 04m

Santo Domingo Las Americas

Wed 6/17

7:35 pm-7:30 pm

1 stop23h 55m

$526

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 7/3

11:04 am-9:25 pm

1 stop10h 21m

Santo Domingo Las Americas

Wed 7/8

7:40 pm-10:22 am

1 stop14h 42m

$535
Quickest round-trip

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 7/3

7:05 am-6:40 pm

2 stops11h 35m

Santo Domingo Las Americas

Wed 7/8

1:57 pm-11:55 pm

1 stop9h 58m

$540

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from Charleston, when ticket prices are also cheap, with an average price of $398.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 15% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from Charleston to Santo Domingo takes 4h 54m
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

Frequently asked questions about flying from Charleston to Santo Domingo

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 4h 54m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $332Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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