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Cheap flights from Charleston to Santo Domingo from $137

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
6:35 pm - 2:27 pm
CHS
-
SDQ
18h 52m1 stop
Spirit Airlines Logo
3:32 pm - 5:36 pm
SDQ
-
CHS
27h 04m1 stop
$292Spirit Airlines
Mon, Feb 2 - Fri, Feb 6
American Airlines Logo
9:27 am - 10:39 pm
CHS
-
SDQ
12h 12m1 stop
American Airlines Logo
6:00 am - 6:48 pm
SDQ
-
CHS
13h 48m1 stop
$318American Airlines
Mon, Feb 2 - Fri, Feb 6
Delta Logo
12:53 pm - 12:30 am
CHS
-
SDQ
10h 37m2 stops
Delta Logo
7:31 am - 8:57 pm
SDQ
-
CHS
14h 26m2 stops
$322Delta
Mon, Feb 2 - Fri, Feb 6
JetBlue Logo
10:10 am - 7:49 pm
CHS
-
SDQ
8h 39m1 stop
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
$362JetBlue
Sun, Jan 25 - Thu, Jan 29
JetBlue Logo
10:10 am - 7:49 pm
CHS
-
SDQ
8h 39m1 stop
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
$387JetBlue
Sun, Jan 25 - Thu, Jan 29
Multiple Airlines Logo
5:05 pm - 2:27 pm
CHS
-
SDQ
20h 22m2 stops
Multiple Airlines Logo
10:19 am - 5:36 pm
SDQ
-
CHS
32h 17m3 stops
$390Multiple Airlines
Mon, Feb 2 - Fri, Feb 6
JetBlue Logo
9:22 am - 6:38 pm
CHS
-
SDQ
9h 16m1 stop
JetBlue Logo
5:01 am - 6:43 pm
SDQ
-
CHS
13h 42m1 stop
$402JetBlue
Thu, Mar 26 - Sun, Mar 29
JetBlue Logo
7:39 pm - 3:31 am
CHS
-
SDQ
7h 52m1 stop
JetBlue Logo
5:01 am - 6:43 pm
SDQ
-
CHS
13h 42m1 stop
$407JetBlue
Thu, Mar 26 - Sun, Mar 29
Multiple Airlines Logo
6:35 pm - 9:45 pm
CHS
-
SDQ
26h 10m3 stops
Multiple Airlines Logo
10:19 am - 5:36 pm
SDQ
-
CHS
32h 17m3 stops
$408Multiple Airlines
Mon, Feb 2 - Fri, Feb 6
American Airlines Logo
6:00 am - 12:21 pm
CHS
-
SDQ
5h 21m1 stop
American Airlines Logo
3:00 pm - 11:58 pm
SDQ
-
CHS
9h 58m1 stop
$410American Airlines
Tue, Jan 13 - Tue, Jan 20

JetBlue flights from Charleston to Santo Domingo

Our best JetBlue deals on Charleston to Santo Domingo flight tickets
JetBlue
Jan 25
CHS10:10 amCharleston
8h 39m
1 stop
SDQ7:49 pmSanto Domingo Las Americas
Jan 29
SDQ9:50 pmSanto Domingo Las Americas
12h 30m
1 stop
CHS9:20 amCharleston
$362
Find similar
JetBlue
Jan 25
CHS10:10 amCharleston
8h 39m
1 stop
SDQ7:49 pmSanto Domingo Las Americas
Jan 29
SDQ9:50 pmSanto Domingo Las Americas
12h 30m
1 stop
CHS9:20 amCharleston
$387
Find similar
JetBlue
Mar 26
CHS9:22 amCharleston
9h 16m
1 stop
SDQ6:38 pmSanto Domingo Las Americas
Mar 29
SDQ5:01 amSanto Domingo Las Americas
13h 42m
1 stop
CHS6:43 pmCharleston
$402
Find similar

American Airlines flights from Charleston to Santo Domingo

Our best American Airlines deals on Charleston to Santo Domingo flight tickets
American Airlines
Feb 2
CHS9:27 amCharleston
12h 12m
1 stop
SDQ10:39 pmSanto Domingo Las Americas
Feb 6
SDQ6:00 amSanto Domingo Las Americas
13h 48m
1 stop
CHS6:48 pmCharleston
$318
Find similar
American Airlines
Jan 13
CHS6:00 amCharleston
5h 21m
1 stop
SDQ12:21 pmSanto Domingo Las Americas
Jan 20
SDQ3:00 pmSanto Domingo Las Americas
9h 58m
1 stop
CHS11:58 pmCharleston
$410
Find similar
American Airlines
Feb 21
CHS4:30 pmCharleston
16h 18m
2 stops
SDQ9:48 amSanto Domingo Las Americas
Feb 28
SDQ7:00 amSanto Domingo Las Americas
12h 07m
2 stops
CHS6:07 pmCharleston
$416
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 2/2

6:35 pm-2:27 pm

1 stop18h 52m

Santo Domingo Las Americas

Fri 2/6

3:32 pm-5:36 pm

1 stop27h 04m

$292

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 2/2

9:27 am-10:39 pm

1 stop12h 12m

Santo Domingo Las Americas

Fri 2/6

6:00 am-6:48 pm

1 stop13h 48m

$318

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 2/2

12:53 pm-12:30 am

2 stops10h 37m

Santo Domingo Las Americas

Fri 2/6

7:31 am-8:57 pm

2 stops14h 26m

$322

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sun 1/25

10:10 am-7:49 pm

1 stop8h 39m

Santo Domingo Las Americas

Thu 1/29

9:50 pm-9:20 am

1 stop12h 30m

$362

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sun 1/25

10:10 am-7:49 pm

1 stop8h 39m

Santo Domingo Las Americas

Thu 1/29

9:50 pm-9:20 am

1 stop12h 30m

$387

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 2/2

5:05 pm-2:27 pm

2 stops20h 22m

Santo Domingo Las Americas

Fri 2/6

10:19 am-5:36 pm

3 stops32h 17m

$390

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/26

9:22 am-6:38 pm

1 stop9h 16m

Santo Domingo Las Americas

Sun 3/29

5:01 am-6:43 pm

1 stop13h 42m

$402

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/26

7:39 pm-3:31 am

1 stop7h 52m

Santo Domingo Las Americas

Sun 3/29

5:01 am-6:43 pm

1 stop13h 42m

$407

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 2/2

6:35 pm-9:45 pm

3 stops26h 10m

Santo Domingo Las Americas

Fri 2/6

10:19 am-5:36 pm

3 stops32h 17m

$408

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 1/13

6:00 am-12:21 pm

1 stop5h 21m

Santo Domingo Las Americas

Tue 1/20

3:00 pm-11:58 pm

1 stop9h 58m

$410

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in January, then you should wait until November to fly from Charleston, when ticket prices are also cheap, with an average price of $375.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $391. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $760.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $257. Try not to purchase tickets in the afternoon because they tend to be around $637. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 69% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

As of December 2025, prices for Charleston to Santo Domingo flights are approximately 150% more expensive when compared to flights at the same time last year.

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Fastest flight time

7h 00m

Direct flights

None
The fastest flight from Charleston to Santo Domingo takes 7h 00m
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 7h 00m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $321Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $338Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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