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Cheap flights from Charleston to Santo Domingo from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 12/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 3:06 pmCHS-SDQ
8h 06m1 stop
United Airlines Logo
4:18 pm - 11:42 pmSDQ-CHS
8h 24m1 stop
$318United Airlines
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Mon, Nov 17 - Thu, Nov 20
Delta Logo
12:51 pm - 1:36 amCHS-SDQ
11h 45m2 stops
Delta Logo
6:45 am - 5:23 pmSDQ-CHS
11h 38m2 stops
$322Delta
Find Deal
Mon, Nov 17 - Thu, Nov 20
American Airlines Logo
8:08 pm - 10:50 amCHS-SDQ
14h 42m1 stop
American Airlines Logo
4:55 pm - 10:42 pmSDQ-CHS
5h 47m1 stop
$334American Airlines
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Fri, Apr 17 - Wed, Apr 22
JetBlue Logo
2:43 pm - 2:22 amCHS-SDQ
10h 39m1 stop
JetBlue Logo
4:10 am - 1:48 pmSDQ-CHS
10h 38m1 stop
$386JetBlue
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Thu, Dec 4 - Wed, Dec 10
American Airlines Logo
5:10 am - 2:04 pmCHS-SDQ
7h 54m2 stops
American Airlines Logo
1:28 pm - 11:13 pmSDQ-CHS
10h 45m2 stops
$397American Airlines
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Mon, Dec 1 - Fri, Dec 12
Multiple Airlines Logo
2:59 pm - 3:32 amCHS-SDQ
11h 33m1 stop
Multiple Airlines Logo
8:01 am - 8:43 amSDQ-CHS
25h 42m1 stop
$425Multiple Airlines
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Tue, Jan 6 - Sun, Jan 11
Multiple Airlines Logo
2:59 pm - 3:32 amCHS-SDQ
11h 33m1 stop
Multiple Airlines Logo
4:19 pm - 10:45 amSDQ-CHS
19h 26m2 stops
$428Multiple Airlines
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Tue, Jan 6 - Sun, Jan 11
Spirit Airlines Logo
11:55 am - 3:23 pmCHS-SDQ
26h 28m3 stops
Spirit Airlines Logo
4:21 pm - 11:00 amSDQ-CHS
19h 39m2 stops
$472Spirit Airlines
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Thu, Dec 4 - Thu, Dec 11
Spirit Airlines Logo
2:15 pm - 2:54 amCHS-SDQ
11h 39m2 stops
Spirit Airlines Logo
8:01 am - 8:34 amSDQ-CHS
25h 33m2 stops
$528Spirit Airlines
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Tue, Jan 6 - Sun, Jan 11
JetBlue Logo
7:41 pm - 4:08 amCHS-SDQ
7h 27m1 stop
JetBlue Logo
4:10 am - 4:59 pmSDQ-CHS
13h 49m1 stop
$579JetBlue
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Tue, Nov 25 - Sun, Nov 30

Delta flights from Charleston to Santo Domingo

Our best Delta deals on Charleston to Santo Domingo flight tickets
Delta
Nov 17
CHS12:51 pmCharleston
11h 45m
2 stops
SDQ1:36 amSanto Domingo Las Americas
Nov 20
SDQ6:45 amSanto Domingo Las Americas
11h 38m
2 stops
CHS5:23 pmCharleston
$322
Find similar
Delta
Mar 3
CHS12:00 pmCharleston
10h 59m
1 stop
SDQ11:59 pmSanto Domingo Las Americas
Mar 5
SDQ7:05 amSanto Domingo Las Americas
16h 01m
1 stop
CHS10:06 pmCharleston
$444
Find similar
Delta
Mar 3
CHS8:30 amCharleston
14h 29m
2 stops
SDQ11:59 pmSanto Domingo Las Americas
Mar 5
SDQ7:05 amSanto Domingo Las Americas
16h 01m
1 stop
CHS10:06 pmCharleston
$448
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American Airlines flights from Charleston to Santo Domingo

Our best American Airlines deals on Charleston to Santo Domingo flight tickets
American Airlines
Apr 17
CHS8:08 pmCharleston
14h 42m
1 stop
SDQ10:50 amSanto Domingo Las Americas
Apr 22
SDQ4:55 pmSanto Domingo Las Americas
5h 47m
1 stop
CHS10:42 pmCharleston
$334
Find similar
American Airlines
Dec 1
CHS5:10 amCharleston
7h 54m
2 stops
SDQ2:04 pmSanto Domingo Las Americas
Dec 12
SDQ1:28 pmSanto Domingo Las Americas
10h 45m
2 stops
CHS11:13 pmCharleston
$397
Find similar
American Airlines
Apr 17
CHS8:08 pmCharleston
14h 42m
1 stop
SDQ10:50 amSanto Domingo Las Americas
Apr 22
SDQ5:55 amSanto Domingo Las Americas
8h 08m
2 stops
CHS2:03 pmCharleston
$405
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momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 11/17

6:00 am-3:06 pm

1 stop8h 06m

Santo Domingo Las Americas

Thu 11/20

4:18 pm-11:42 pm

1 stop8h 24m

$318

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 11/17

12:51 pm-1:36 am

2 stops11h 45m

Santo Domingo Las Americas

Thu 11/20

6:45 am-5:23 pm

2 stops11h 38m

$322

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 4/17

8:08 pm-10:50 am

1 stop14h 42m

Santo Domingo Las Americas

Wed 4/22

4:55 pm-10:42 pm

1 stop5h 47m

$334

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 12/4

2:43 pm-2:22 am

1 stop10h 39m

Santo Domingo Las Americas

Wed 12/10

4:10 am-1:48 pm

1 stop10h 38m

$386

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Mon 12/1

5:10 am-2:04 pm

2 stops7h 54m

Santo Domingo Las Americas

Fri 12/12

1:28 pm-11:13 pm

2 stops10h 45m

$397

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 1/6

2:59 pm-3:32 am

1 stop11h 33m

Santo Domingo Las Americas

Sun 1/11

8:01 am-8:43 am

1 stop25h 42m

$425

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 1/6

2:59 pm-3:32 am

1 stop11h 33m

Santo Domingo Las Americas

Sun 1/11

4:19 pm-10:45 am

2 stops19h 26m

$428

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 12/4

11:55 am-3:23 pm

3 stops26h 28m

Santo Domingo Las Americas

Thu 12/11

4:21 pm-11:00 am

2 stops19h 39m

$472

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 1/6

2:15 pm-2:54 am

2 stops11h 39m

Santo Domingo Las Americas

Sun 1/11

8:01 am-8:34 am

2 stops25h 33m

$528

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 11/25

7:41 pm-4:08 am

1 stop7h 27m

Santo Domingo Las Americas

Sun 11/30

4:10 am-4:59 pm

1 stop13h 49m

$579

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from Charleston, when ticket prices are also cheap, with an average price of $410.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $391. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $760.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $257. Try not to purchase tickets in the afternoon because they tend to be around $637. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 39% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

As of November 2025, prices for Charleston to Santo Domingo flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Direct flights

None
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
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  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 6h 34m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $338Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $420Free CancellationRating
7.9
8,003 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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