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Cheap flights from Charleston to Santo Domingo from $147

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 11/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

American Airlines Logo
9:42 am - 3:20 pmCHS-SDQ
5h 38m1 stop
American Airlines Logo
7:00 am - 7:04 pmSDQ-CHS
12h 04m1 stop
$315American Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21
American Airlines Logo
6:00 am - 3:20 pmCHS-SDQ
9h 20m1 stop
American Airlines Logo
6:14 pm - 11:59 pmSDQ-CHS
6h 45m1 stop
$316American Airlines
Find Deal
Wed, Oct 15 - Fri, Nov 14
Delta Logo
6:00 am - 7:08 pmCHS-SDQ
12h 08m1 stop
Delta Logo
6:45 am - 5:05 pmSDQ-CHS
11h 20m1 stop
$317Delta
Find Deal
Fri, Nov 14 - Wed, Nov 19
Multiple Airlines Logo
12:08 pm - 4:00 pmCHS-SDQ
27h 52m1 stop
Multiple Airlines Logo
6:18 am - 8:15 pmSDQ-CHS
13h 57m1 stop
$323Multiple Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
Spirit Airlines Logo
10:11 am - 2:48 pmCHS-SDQ
4h 37m1 stop
Spirit Airlines Logo
3:54 pm - 8:15 pmSDQ-CHS
28h 21m2 stops
$338Spirit Airlines
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Thu, Oct 16 - Thu, Oct 23
Multiple Airlines Logo
5:08 pm - 4:30 pmCHS-SDQ
23h 22m1 stop
Multiple Airlines Logo
3:54 pm - 9:06 amSDQ-CHS
17h 12m1 stop
$373Multiple Airlines
Find Deal
Thu, Oct 16 - Thu, Oct 23
JetBlue Logo
5:20 pm - 10:32 amCHS-SDQ
16h 12m1 stop
JetBlue Logo
4:10 am - 1:19 pmSDQ-CHS
10h 09m1 stop
$379JetBlue
Find Deal
Fri, Nov 14 - Tue, Nov 18
Spirit Airlines Logo
10:11 am - 2:48 pmCHS-SDQ
4h 37m1 stop
Spirit Airlines Logo
3:54 pm - 8:15 pmSDQ-CHS
28h 21m3 stops
$380Spirit Airlines
Find Deal
Thu, Oct 16 - Thu, Oct 23
JetBlue Logo
11:10 am - 11:37 pmCHS-SDQ
12h 27m1 stop
JetBlue Logo
4:10 am - 10:27 pmSDQ-CHS
19h 17m1 stop
$416JetBlue
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Wed, Oct 15 - Thu, Nov 13
Delta Logo
6:00 am - 7:08 pmCHS-SDQ
12h 08m1 stop
Delta Logo
7:05 am - 8:52 pmSDQ-CHS
14h 47m1 stop
$496Delta
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Tue, Nov 18 - Mon, Jan 12

American Airlines flights from Charleston to Santo Domingo

Our best American Airlines deals on Charleston to Santo Domingo flight tickets
American Airlines
Oct 14
CHS9:42 amCharleston
5h 38m
1 stop
SDQ3:20 pmSanto Domingo Las Americas
Oct 21
SDQ7:00 amSanto Domingo Las Americas
12h 04m
1 stop
CHS7:04 pmCharleston
$315
Find similar
American Airlines
Oct 15
CHS6:00 amCharleston
9h 20m
1 stop
SDQ3:20 pmSanto Domingo Las Americas
Nov 14
SDQ6:14 pmSanto Domingo Las Americas
6h 45m
1 stop
CHS11:59 pmCharleston
$316
Find similar
American Airlines
Oct 14
CHS7:41 pmCharleston
13h 44m
2 stops
SDQ9:25 amSanto Domingo Las Americas
Oct 21
SDQ10:25 amSanto Domingo Las Americas
10h 14m
2 stops
CHS8:39 pmCharleston
$319
Find similar

Delta flights from Charleston to Santo Domingo

Our best Delta deals on Charleston to Santo Domingo flight tickets
Delta
Sep 25
CHS12:51 pmCharleston
11h 45m
1 stop
SDQ12:36 amSanto Domingo Las Americas
Sep 30
SDQ6:03 amSanto Domingo Las Americas
10h 54m
1 stop
CHS4:57 pmCharleston
$315
Find similar
Delta
Nov 14
CHS6:00 amCharleston
12h 08m
1 stop
SDQ7:08 pmSanto Domingo Las Americas
Nov 19
SDQ6:45 amSanto Domingo Las Americas
11h 20m
1 stop
CHS5:05 pmCharleston
$317
Find similar
Delta
Sep 25
CHS12:51 pmCharleston
11h 45m
1 stop
SDQ12:36 amSanto Domingo Las Americas
Sep 30
SDQ6:03 amSanto Domingo Las Americas
12h 54m
2 stops
CHS6:57 pmCharleston
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 10/14

9:42 am-3:20 pm

1 stop5h 38m

Santo Domingo Las Americas

Tue 10/21

7:00 am-7:04 pm

1 stop12h 04m

$315

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 10/15

6:00 am-3:20 pm

1 stop9h 20m

Santo Domingo Las Americas

Fri 11/14

6:14 pm-11:59 pm

1 stop6h 45m

$316

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 11/14

6:00 am-7:08 pm

1 stop12h 08m

Santo Domingo Las Americas

Wed 11/19

6:45 am-5:05 pm

1 stop11h 20m

$317

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/2

12:08 pm-4:00 pm

1 stop27h 52m

Santo Domingo Las Americas

Mon 10/6

6:18 am-8:15 pm

1 stop13h 57m

$323

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/16

10:11 am-2:48 pm

1 stop4h 37m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-8:15 pm

2 stops28h 21m

$338

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/16

5:08 pm-4:30 pm

1 stop23h 22m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-9:06 am

1 stop17h 12m

$373

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 11/14

5:20 pm-10:32 am

1 stop16h 12m

Santo Domingo Las Americas

Tue 11/18

4:10 am-1:19 pm

1 stop10h 09m

$379

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/16

10:11 am-2:48 pm

1 stop4h 37m

Santo Domingo Las Americas

Thu 10/23

3:54 pm-8:15 pm

3 stops28h 21m

$380

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 10/15

11:10 am-11:37 pm

1 stop12h 27m

Santo Domingo Las Americas

Thu 11/13

4:10 am-10:27 pm

1 stop19h 17m

$416

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 11/18

6:00 am-7:08 pm

1 stop12h 08m

Santo Domingo Las Americas

Mon 1/12

7:05 am-8:52 pm

1 stop14h 47m

$496

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until November to fly from Charleston, when ticket prices are also cheap, with an average price of $440.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $391. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $760.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $257. Try not to purchase tickets in the afternoon because they tend to be around $637. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have Charleston to Santo Domingo flight prices changed over time?

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Direct flights

None
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 4h 37m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $420Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $420Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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