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Cheap flights from Charleston to Santo Domingo from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santo Domingo departing on 3/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
7:00 am - 2:32 pm
CHS
-
SDQ
7h 32m
1 stop
Spirit Airlines Logo
3:37 pm - 10:41 pm
SDQ
-
CHS
7h 04m
1 stop
$267Spirit Airlines
Thu, Apr 23 - Thu, Apr 30
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
$268Spirit Airlines
Sat, Mar 21 - Sat, Mar 28
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
$282Spirit Airlines
Fri, Mar 27 - Tue, Apr 7
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
$299Spirit Airlines
Thu, Apr 9 - Mon, Apr 13
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
$300Spirit Airlines
Thu, Mar 26 - Sun, Mar 29
Spirit Airlines Logo
8:07 am - 1:38 am
CHS
-
SDQ
17h 31m
1 stop
Spirit Airlines Logo
2:52 am - 10:13 pm
SDQ
-
CHS
19h 21m
1 stop
$302Spirit Airlines
Thu, Mar 19 - Sun, Mar 22
Spirit Airlines Logo
8:07 am - 1:15 pm
CHS
-
SDQ
5h 08m
1 stop
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
$318Spirit Airlines
Thu, Mar 26 - Sun, Mar 29
JetBlue Logo
12:36 pm - 2:55 am
CHS
-
SDQ
13h 19m
1 stop
JetBlue Logo
9:36 pm - 10:58 am
SDQ
-
CHS
13h 22m
1 stop
$322JetBlue
Thu, Mar 5 - Sun, Mar 8
Delta Logo
6:25 am - 1:12 pm
CHS
-
SDQ
6h 47m
1 stop
Delta Logo
2:37 pm - 12:22 am
SDQ
-
CHS
9h 45m
1 stop
$323Delta
Wed, Apr 22 - Mon, Apr 27
Delta Logo
5:20 am - 6:34 pm
CHS
-
SDQ
13h 14m
2 stops
Delta Logo
2:37 pm - 9:55 pm
SDQ
-
CHS
7h 18m
1 stop
$327Delta
Wed, Apr 22 - Sat, Apr 25

Spirit Airlines flights from Charleston to Santo Domingo

Our best Spirit Airlines deals on Charleston to Santo Domingo flight tickets
Spirit Airlines
Mar 21
CHS8:07 amCharleston
5h 08m
1 stop
SDQ1:15 pmSanto Domingo Las Americas
Mar 28
SDQ2:20 pmSanto Domingo Las Americas
7h 53m
1 stop
CHS10:13 pmCharleston
$268
Spirit Airlines
Mar 27
CHS8:07 amCharleston
5h 08m
1 stop
SDQ1:15 pmSanto Domingo Las Americas
Apr 7
SDQ2:20 pmSanto Domingo Las Americas
7h 53m
1 stop
CHS10:13 pmCharleston
$282
Spirit Airlines
Mar 26
CHS8:07 amCharleston
5h 08m
1 stop
SDQ1:15 pmSanto Domingo Las Americas
Mar 29
SDQ2:20 pmSanto Domingo Las Americas
7h 53m
1 stop
CHS10:13 pmCharleston
$300

Delta flights from Charleston to Santo Domingo

Our best Delta deals on Charleston to Santo Domingo flight tickets
Delta
Apr 22
CHS6:25 amCharleston
6h 47m
1 stop
SDQ1:12 pmSanto Domingo Las Americas
Apr 27
SDQ2:37 pmSanto Domingo Las Americas
9h 45m
1 stop
CHS12:22 amCharleston
$323
Delta
Apr 22
CHS5:20 amCharleston
13h 14m
2 stops
SDQ6:34 pmSanto Domingo Las Americas
Apr 25
SDQ2:37 pmSanto Domingo Las Americas
7h 18m
1 stop
CHS9:55 pmCharleston
$327
Delta
Feb 25
CHS6:00 amCharleston
12h 14m
1 stop
SDQ7:14 pmSanto Domingo Las Americas
Mar 3
SDQ7:30 amSanto Domingo Las Americas
10h 40m
1 stop
CHS5:10 pmCharleston
$391

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Charleston to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/23

7:00 am-2:32 pm

1 stop7h 32m

Santo Domingo Las Americas

Thu 4/30

3:37 pm-10:41 pm

1 stop7h 04m

$267

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 3/21

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Sat 3/28

2:20 pm-10:13 pm

1 stop7h 53m

$268

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 3/27

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Tue 4/7

2:20 pm-10:13 pm

1 stop7h 53m

$282

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/9

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Mon 4/13

2:20 pm-10:13 pm

1 stop7h 53m

$299

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/26

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Sun 3/29

2:20 pm-10:13 pm

1 stop7h 53m

$300

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/19

8:07 am-1:38 am

1 stop17h 31m

Santo Domingo Las Americas

Sun 3/22

2:52 am-10:13 pm

1 stop19h 21m

$302

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/26

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Sun 3/29

2:20 pm-10:13 pm

1 stop7h 53m

$318

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 3/5

12:36 pm-2:55 am

1 stop13h 19m

Santo Domingo Las Americas

Sun 3/8

9:36 pm-10:58 am

1 stop13h 22m

$322

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

6:25 am-1:12 pm

1 stop6h 47m

Santo Domingo Las Americas

Mon 4/27

2:37 pm-12:22 am

1 stop9h 45m

$323

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 4/22

5:20 am-6:34 pm

2 stops13h 14m

Santo Domingo Las Americas

Sat 4/25

2:37 pm-9:55 pm

1 stop7h 18m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Charleston to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in November, then you should wait until January to fly from Charleston, when ticket prices are also cheap, with an average price of $400.

Can stopping save me money on Charleston to Santo Domingo flights?

You could potentially save up to 30% on your flight if you consider stops on a Charleston to Santo Domingo flight.

How have Charleston to Santo Domingo flight prices changed over time?

When to book flights from Charleston to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santo Domingo (CHS to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santo Domingo

Fastest flight time

5h 08m

Direct flights

None
The fastest flight from Charleston to Santo Domingo takes 5h 08m
There are no direct flights from Charleston to Santo Domingo. There are no popular flight routes from Charleston to Santo Domingo.
Search flight deals

  • How far is Charleston to Santo Domingo Las Americas by plane?

    There are 1165.2 mi between Charleston and Santo Domingo Las Americas. By plane, this route typically takes 5h 08m.

  • When did momondo last update prices for flights from Charleston Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Charleston Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Charleston Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Santo Domingo?

Best airlines flying from Charleston to Santo Domingo

Compare and see reviews for airlines that fly from Charleston to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $321Free CancellationRating
7.9
8,162 reviews
Search Delta flights
American AirlinesPriceFrom $333Free CancellationRating
7.2
11,248 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santo Domingo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Santo Domingo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Charleston with this policy.

How can momondo help me find flights from Charleston to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charleston to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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