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Cheap flights from St. Louis to Santo Domingo from $318

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santo Domingo departing on 3/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
1:09 pm - 10:51 am
STL
-
SDQ
19h 42m
2 stops
Frontier Logo
10:56 am - 8:08 pm
SDQ
-
STL
10h 12m
1 stop
$484Frontier
Fri, Mar 6 - Sat, Mar 14
American Airlines Logo
11:22 am - 10:53 pm
STL
-
SDQ
10h 31m
1 stop
American Airlines Logo
6:00 am - 5:40 pm
SDQ
-
STL
12h 40m
1 stop
$539American Airlines
Mon, Mar 9 - Tue, Mar 24
American Airlines Logo
7:05 am - 10:53 pm
STL
-
SDQ
14h 48m
2 stops
American Airlines Logo
6:00 am - 7:29 pm
SDQ
-
STL
14h 29m
2 stops
$543American Airlines
Mon, Mar 9 - Tue, Mar 24
American Airlines Logo
5:24 am - 2:59 pm
STL
-
SDQ
8h 35m
1 stop
American Airlines Logo
5:55 pm - 10:16 am
SDQ
-
STL
17h 21m
1 stop
$554American Airlines
Wed, Apr 15 - Sun, Apr 19
American Airlines Logo
6:00 am - 4:55 pm
STL
-
SDQ
9h 55m
2 stops
American Airlines Logo
5:55 pm - 10:16 am
SDQ
-
STL
17h 21m
1 stop
$558American Airlines
Wed, Apr 15 - Sun, Apr 19
American Airlines Logo
6:20 pm - 8:43 am
STL
-
SDQ
13h 23m
1 stop
American Airlines Logo
5:50 pm - 10:32 am
SDQ
-
STL
17h 42m
1 stop
$559American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
6:12 pm - 9:21 am
STL
-
SDQ
14h 09m
2 stops
American Airlines Logo
7:38 pm - 10:34 am
SDQ
-
STL
15h 56m
1 stop
$578American Airlines
Thu, May 28 - Sun, May 31
Multiple Airlines Logo
4:51 pm - 9:41 am
STL
-
SDQ
15h 50m
1 stop
Multiple Airlines Logo
3:35 pm - 10:32 am
SDQ
-
STL
43h 57m
2 stops
$607Multiple Airlines
Sun, Mar 15 - Sun, Mar 22
American Airlines Logo
6:00 am - 4:55 pm
STL
-
SDQ
9h 55m
2 stops
American Airlines Logo
4:00 pm - 8:28 am
SDQ
-
STL
17h 28m
2 stops
$628American Airlines
Wed, Apr 15 - Sun, Apr 19
American Airlines Logo
6:20 pm - 8:43 am
STL
-
SDQ
13h 23m
1 stop
American Airlines Logo
4:03 pm - 8:35 am
SDQ
-
STL
17h 32m
2 stops
$633American Airlines
Fri, Mar 27 - Sat, Apr 4

American Airlines flights from St. Louis to Santo Domingo

Our best American Airlines deals on St. Louis to Santo Domingo flight tickets
American Airlines
Mar 9
STL11:22 amLambert-St Louis
10h 31m
1 stop
SDQ10:53 pmSanto Domingo Las Americas
Mar 24
SDQ6:00 amSanto Domingo Las Americas
12h 40m
1 stop
STL5:40 pmLambert-St Louis
$539
American Airlines
Mar 9
STL6:00 amLambert-St Louis
9h 50m
2 stops
SDQ4:50 pmSanto Domingo Las Americas
Mar 24
SDQ2:16 pmSanto Domingo Las Americas
10h 42m
1 stop
STL11:58 pmLambert-St Louis
$543
American Airlines
Apr 15
STL5:24 amLambert-St Louis
8h 35m
1 stop
SDQ2:59 pmSanto Domingo Las Americas
Apr 19
SDQ5:55 pmSanto Domingo Las Americas
17h 21m
1 stop
STL10:16 amLambert-St Louis
$554

United Airlines flights from St. Louis to Santo Domingo

Our best United Airlines deals on St. Louis to Santo Domingo flight tickets
United Airlines
Jan 31
STL8:05 amLambert-St Louis
13h 41m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 3
SDQ4:18 pmSanto Domingo Las Americas
9h 41m
1 stop
STL11:59 pmLambert-St Louis
$713
United Airlines
Jan 31
STL11:22 amLambert-St Louis
10h 24m
1 stop
SDQ11:46 pmSanto Domingo Las Americas
Feb 3
SDQ2:53 pmSanto Domingo Las Americas
11h 06m
1 stop
STL11:59 pmLambert-St Louis
$749
United Airlines
Jan 31
STL4:49 pmLambert-St Louis
20h 17m
2 stops
SDQ3:06 pmSanto Domingo Las Americas
Feb 3
SDQ4:18 pmSanto Domingo Las Americas
9h 41m
1 stop
STL11:59 pmLambert-St Louis
$753

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/6

1:09 pm-10:51 am

2 stops19h 42m

Santo Domingo Las Americas

Sat 3/14

10:56 am-8:08 pm

1 stop10h 12m

$484

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 3/9

11:22 am-10:53 pm

1 stop10h 31m

Santo Domingo Las Americas

Tue 3/24

6:00 am-5:40 pm

1 stop12h 40m

$539

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 3/9

7:05 am-10:53 pm

2 stops14h 48m

Santo Domingo Las Americas

Tue 3/24

6:00 am-7:29 pm

2 stops14h 29m

$543

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 4/15

5:24 am-2:59 pm

1 stop8h 35m

Santo Domingo Las Americas

Sun 4/19

5:55 pm-10:16 am

1 stop17h 21m

$554

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 4/15

6:00 am-4:55 pm

2 stops9h 55m

Santo Domingo Las Americas

Sun 4/19

5:55 pm-10:16 am

1 stop17h 21m

$558

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:43 am

1 stop13h 23m

Santo Domingo Las Americas

Sat 4/4

5:50 pm-10:32 am

1 stop17h 42m

$559

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 5/28

6:12 pm-9:21 am

2 stops14h 09m

Santo Domingo Las Americas

Sun 5/31

7:38 pm-10:34 am

1 stop15h 56m

$578

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 3/15

4:51 pm-9:41 am

1 stop15h 50m

Santo Domingo Las Americas

Sun 3/22

3:35 pm-10:32 am

2 stops43h 57m

$607

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 4/15

6:00 am-4:55 pm

2 stops9h 55m

Santo Domingo Las Americas

Sun 4/19

4:00 pm-8:28 am

2 stops17h 28m

$628

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:43 am

1 stop13h 23m

Santo Domingo Las Americas

Sat 4/4

4:03 pm-8:35 am

2 stops17h 32m

$633

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from St. Louis to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until March to fly from St. Louis, when ticket prices are also cheap, with an average price of $534.

When to book flights from St. Louis to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santo Domingo (STL to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santo Domingo

Fastest flight time

10h 24m

Direct flights

None
The fastest flight from St. Louis to Santo Domingo takes 10h 24m
There are no direct flights from St. Louis to Santo Domingo. There are no popular flight routes from St. Louis to Santo Domingo.
Search flight deals

  • How far is Lambert-St Louis to Santo Domingo Las Americas by plane?

    The straight-line distance from Lambert-St Louis to Santo Domingo Las Americas is 1847.1 mi. A reasonable flight in good conditions will take 10h 24m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santo Domingo?

Best airlines flying from St. Louis to Santo Domingo

Compare and see reviews for airlines that fly from St. Louis to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $514Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $549Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Why should I use momondo to find a flight deal from St. Louis to Santo Domingo?

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Can I find flights from St. Louis to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

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