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Cheap flights from St. Louis to Santo Domingo from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santo Domingo departing on 3/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:54 pm - 10:07 am
STL
-
SDQ
16h 13m
1 stop
Frontier Logo
4:35 pm - 11:25 pm
SDQ
-
STL
7h 50m
1 stop
$408Frontier
Thu, Apr 2 - Wed, Apr 8
Frontier Logo
4:51 pm - 9:41 am
STL
-
SDQ
15h 50m
1 stop
Frontier Logo
3:01 pm - 10:30 am
SDQ
-
STL
20h 29m
2 stops
$439Frontier
Fri, Mar 27 - Mon, Apr 6
Frontier Logo
4:54 pm - 10:07 am
STL
-
SDQ
16h 13m
1 stop
Frontier Logo
4:35 pm - 5:34 pm
SDQ
-
STL
25h 59m
2 stops
$440Frontier
Thu, Apr 2 - Wed, Apr 8
Frontier Logo
4:51 pm - 9:41 am
STL
-
SDQ
15h 50m
1 stop
Frontier Logo
4:08 pm - 10:30 am
SDQ
-
STL
19h 22m
1 stop
$446Frontier
Fri, Mar 27 - Mon, Apr 6
Frontier Logo
4:44 pm - 10:57 am
STL
-
SDQ
17h 13m
1 stop
Frontier Logo
10:15 am - 11:57 pm
SDQ
-
STL
14h 42m
1 stop
$495Frontier
Sun, May 31 - Sat, Jun 6
Frontier Logo
4:59 pm - 2:53 pm
STL
-
SDQ
44h 54m
2 stops
Frontier Logo
3:01 pm - 6:50 am
SDQ
-
STL
40h 49m
2 stops
$499Frontier
Mon, Apr 6 - Mon, Apr 13
Frontier Logo
4:59 pm - 2:53 pm
STL
-
SDQ
44h 54m
2 stops
Frontier Logo
11:12 am - 11:25 pm
SDQ
-
STL
13h 13m
1 stop
$532Frontier
Mon, Apr 6 - Mon, Apr 13
Multiple Airlines Logo
4:59 pm - 2:30 pm
STL
-
SDQ
20h 31m
1 stop
Multiple Airlines Logo
2:35 pm - 6:50 am
SDQ
-
STL
17h 15m
2 stops
$546Multiple Airlines
Fri, Apr 10 - Fri, Apr 17
American Airlines Logo
5:24 am - 2:59 pm
STL
-
SDQ
8h 35m
1 stop
American Airlines Logo
4:00 pm - 10:24 pm
SDQ
-
STL
7h 24m
1 stop
$561American Airlines
Thu, Apr 23 - Thu, Apr 30
American Airlines Logo
5:24 am - 1:18 pm
STL
-
SDQ
6h 54m
1 stop
American Airlines Logo
4:00 pm - 10:24 pm
SDQ
-
STL
7h 24m
1 stop
$578American Airlines
Fri, Apr 24 - Fri, May 1

Frontier flights from St. Louis to Santo Domingo

Our best Frontier deals on St. Louis to Santo Domingo flight tickets
Frontier
Apr 2
STL4:54 pmLambert-St Louis
16h 13m
1 stop
SDQ10:07 amSanto Domingo Las Americas
Apr 8
SDQ4:35 pmSanto Domingo Las Americas
7h 50m
1 stop
STL11:25 pmLambert-St Louis
$408
Frontier
Mar 27
STL4:51 pmLambert-St Louis
15h 50m
1 stop
SDQ9:41 amSanto Domingo Las Americas
Apr 6
SDQ3:01 pmSanto Domingo Las Americas
20h 29m
2 stops
STL10:30 amLambert-St Louis
$439
Frontier
Apr 2
STL4:54 pmLambert-St Louis
16h 13m
1 stop
SDQ10:07 amSanto Domingo Las Americas
Apr 8
SDQ4:35 pmSanto Domingo Las Americas
25h 59m
2 stops
STL5:34 pmLambert-St Louis
$440

American Airlines flights from St. Louis to Santo Domingo

Our best American Airlines deals on St. Louis to Santo Domingo flight tickets
American Airlines
Apr 24
STL5:24 amLambert-St Louis
6h 54m
1 stop
SDQ1:18 pmSanto Domingo Las Americas
May 1
SDQ4:00 pmSanto Domingo Las Americas
7h 24m
1 stop
STL10:24 pmLambert-St Louis
$578
American Airlines
Apr 23
STL11:06 amLambert-St Louis
10h 46m
1 stop
SDQ10:52 pmSanto Domingo Las Americas
Apr 30
SDQ5:55 pmSanto Domingo Las Americas
17h 21m
1 stop
STL10:16 amLambert-St Louis
$589
American Airlines
Apr 23
STL5:24 amLambert-St Louis
10h 31m
1 stop
SDQ4:55 pmSanto Domingo Las Americas
Apr 30
SDQ10:20 amSanto Domingo Las Americas
14h 26m
2 stops
STL11:46 pmLambert-St Louis
$593

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 4/2

4:54 pm-10:07 am

1 stop16h 13m

Santo Domingo Las Americas

Wed 4/8

4:35 pm-11:25 pm

1 stop7h 50m

$408

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

4:51 pm-9:41 am

1 stop15h 50m

Santo Domingo Las Americas

Mon 4/6

3:01 pm-10:30 am

2 stops20h 29m

$439

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 4/2

4:54 pm-10:07 am

1 stop16h 13m

Santo Domingo Las Americas

Wed 4/8

4:35 pm-5:34 pm

2 stops25h 59m

$440

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

4:51 pm-9:41 am

1 stop15h 50m

Santo Domingo Las Americas

Mon 4/6

4:08 pm-10:30 am

1 stop19h 22m

$446

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 5/31

4:44 pm-10:57 am

1 stop17h 13m

Santo Domingo Las Americas

Sat 6/6

10:15 am-11:57 pm

1 stop14h 42m

$495

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 4/6

4:59 pm-2:53 pm

2 stops44h 54m

Santo Domingo Las Americas

Mon 4/13

3:01 pm-6:50 am

2 stops40h 49m

$499

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 4/6

4:59 pm-2:53 pm

2 stops44h 54m

Santo Domingo Las Americas

Mon 4/13

11:12 am-11:25 pm

1 stop13h 13m

$532

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 4/10

4:59 pm-2:30 pm

1 stop20h 31m

Santo Domingo Las Americas

Fri 4/17

2:35 pm-6:50 am

2 stops17h 15m

$546

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 4/23

5:24 am-2:59 pm

1 stop8h 35m

Santo Domingo Las Americas

Thu 4/30

4:00 pm-10:24 pm

1 stop7h 24m

$561
Quickest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 4/24

5:24 am-1:18 pm

1 stop6h 54m

Santo Domingo Las Americas

Fri 5/1

4:00 pm-10:24 pm

1 stop7h 24m

$578

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from St. Louis to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until February to fly from St. Louis, when ticket prices are also cheap, with an average price of $580.

When to book flights from St. Louis to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santo Domingo (STL to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santo Domingo

Fastest flight time

6h 23m

Direct flights

None
The fastest flight from St. Louis to Santo Domingo takes 6h 23m
There are no direct flights from St. Louis to Santo Domingo. There are no popular flight routes from St. Louis to Santo Domingo.
Search flight deals

  • How far is Lambert-St Louis to Santo Domingo Las Americas by plane?

    The straight-line distance from Lambert-St Louis to Santo Domingo Las Americas is 1847.1 mi. A reasonable flight in good conditions will take 6h 23m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santo Domingo?

Best airlines flying from St. Louis to Santo Domingo

Compare and see reviews for airlines that fly from St. Louis to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $524Free CancellationRating
7.9
8,291 reviews
Search Delta flights
American AirlinesPriceFrom $538Free CancellationRating
7.1
11,464 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

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