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Cheap flights from St. Louis to Santo Domingo from $391

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santo Domingo departing on 1/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:11 pm - 2:27 pm
STL
-
SDQ
19h 16m2 stops
Multiple Airlines Logo
4:29 pm - 6:51 am
SDQ
-
STL
16h 22m1 stop
$391Multiple Airlines
Tue, Jan 13 - Sun, Jan 18
Frontier Logo
5:11 pm - 3:09 pm
STL
-
SDQ
43h 58m2 stops
Frontier Logo
11:09 am - 6:51 am
SDQ
-
STL
21h 42m2 stops
$491Frontier
Tue, Jan 13 - Sun, Jan 18
American Airlines Logo
6:02 pm - 12:21 pm
STL
-
SDQ
16h 19m1 stop
American Airlines Logo
6:43 pm - 10:26 am
SDQ
-
STL
17h 43m1 stop
$518American Airlines
Tue, Feb 3 - Tue, Feb 24
Delta Logo
5:04 pm - 1:10 pm
STL
-
SDQ
18h 06m2 stops
Delta Logo
7:30 am - 7:22 pm
SDQ
-
STL
13h 52m2 stops
$522Delta
Tue, Feb 3 - Tue, Feb 24
American Airlines Logo
5:12 am - 4:50 pm
STL
-
SDQ
10h 38m2 stops
American Airlines Logo
5:52 pm - 10:32 am
SDQ
-
STL
17h 40m1 stop
$532American Airlines
Wed, Mar 18 - Mon, Mar 23
American Airlines Logo
6:20 pm - 8:41 am
STL
-
SDQ
13h 21m1 stop
American Airlines Logo
6:00 am - 5:40 pm
SDQ
-
STL
12h 40m1 stop
$538American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
6:20 pm - 8:41 am
STL
-
SDQ
13h 21m1 stop
American Airlines Logo
6:00 am - 5:13 pm
SDQ
-
STL
12h 13m2 stops
$594American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
5:30 am - 10:00 pm
STL
-
SDQ
14h 30m1 stop
American Airlines Logo
6:29 pm - 9:08 am
SDQ
-
STL
16h 39m1 stop
$613American Airlines
Mon, Dec 29 - Mon, Jan 12
United Airlines Logo
11:22 am - 11:46 pm
STL
-
SDQ
10h 24m1 stop
United Airlines Logo
2:53 pm - 11:59 pm
SDQ
-
STL
11h 06m1 stop
$638United Airlines
Mon, Jan 26 - Mon, Feb 2
United Airlines Logo
8:05 am - 11:46 pm
STL
-
SDQ
13h 41m2 stops
United Airlines Logo
4:18 pm - 12:29 pm
SDQ
-
STL
22h 11m2 stops
$642United Airlines
Mon, Jan 26 - Mon, Feb 2

Frontier flights from St. Louis to Santo Domingo

Our best Frontier deals on St. Louis to Santo Domingo flight tickets
Frontier
Jan 13
STL5:11 pmLambert-St Louis
43h 58m
2 stops
SDQ3:09 pmSanto Domingo Las Americas
Jan 18
SDQ11:09 amSanto Domingo Las Americas
21h 42m
2 stops
STL6:51 amLambert-St Louis
$491
Find similar
Frontier
Jan 1
STL10:42 amLambert-St Louis
20h 44m
2 stops
SDQ9:26 amSanto Domingo Las Americas
Jan 6
SDQ1:55 pmSanto Domingo Las Americas
10h 38m
1 stop
STL10:33 pmLambert-St Louis
$780
Find similar
Frontier
Jan 1
STL10:42 amLambert-St Louis
20h 44m
2 stops
SDQ9:26 amSanto Domingo Las Americas
Jan 6
SDQ1:55 pmSanto Domingo Las Americas
22h 07m
2 stops
STL10:02 amLambert-St Louis
$807
Find similar

American Airlines flights from St. Louis to Santo Domingo

Our best American Airlines deals on St. Louis to Santo Domingo flight tickets
American Airlines
Feb 3
STL6:02 pmLambert-St Louis
16h 19m
1 stop
SDQ12:21 pmSanto Domingo Las Americas
Feb 24
SDQ6:43 pmSanto Domingo Las Americas
17h 43m
1 stop
STL10:26 amLambert-St Louis
$518
Find similar
American Airlines
Mar 18
STL5:12 amLambert-St Louis
10h 38m
2 stops
SDQ4:50 pmSanto Domingo Las Americas
Mar 23
SDQ5:52 pmSanto Domingo Las Americas
17h 40m
1 stop
STL10:32 amLambert-St Louis
$532
Find similar
American Airlines
Mar 27
STL6:20 pmLambert-St Louis
13h 21m
1 stop
SDQ8:41 amSanto Domingo Las Americas
Apr 4
SDQ6:00 amSanto Domingo Las Americas
12h 40m
1 stop
STL5:40 pmLambert-St Louis
$538
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 1/13

5:11 pm-2:27 pm

2 stops19h 16m

Santo Domingo Las Americas

Sun 1/18

4:29 pm-6:51 am

1 stop16h 22m

$391

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 1/13

5:11 pm-3:09 pm

2 stops43h 58m

Santo Domingo Las Americas

Sun 1/18

11:09 am-6:51 am

2 stops21h 42m

$491

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

6:02 pm-12:21 pm

1 stop16h 19m

Santo Domingo Las Americas

Tue 2/24

6:43 pm-10:26 am

1 stop17h 43m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

5:04 pm-1:10 pm

2 stops18h 06m

Santo Domingo Las Americas

Tue 2/24

7:30 am-7:22 pm

2 stops13h 52m

$522

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 3/18

5:12 am-4:50 pm

2 stops10h 38m

Santo Domingo Las Americas

Mon 3/23

5:52 pm-10:32 am

1 stop17h 40m

$532

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:41 am

1 stop13h 21m

Santo Domingo Las Americas

Sat 4/4

6:00 am-5:40 pm

1 stop12h 40m

$538

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:41 am

1 stop13h 21m

Santo Domingo Las Americas

Sat 4/4

6:00 am-5:13 pm

2 stops12h 13m

$594

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 12/29

5:30 am-10:00 pm

1 stop14h 30m

Santo Domingo Las Americas

Mon 1/12

6:29 pm-9:08 am

1 stop16h 39m

$613

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 1/26

11:22 am-11:46 pm

1 stop10h 24m

Santo Domingo Las Americas

Mon 2/2

2:53 pm-11:59 pm

1 stop11h 06m

$638

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 1/26

8:05 am-11:46 pm

2 stops13h 41m

Santo Domingo Las Americas

Mon 2/2

4:18 pm-12:29 pm

2 stops22h 11m

$642

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santo Domingo from

How to get the cheapest flight ticket from St. Louis to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until September to fly from St. Louis, when ticket prices are also cheap, with an average price of $533.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $486. The most expensive day to fly to Santo Domingo is Friday, with ticket prices averaging around $765.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $445. Try not to purchase tickets in the morning because they tend to be around $610. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from St. Louis to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santo Domingo (STL to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santo Domingo

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from St. Louis to Santo Domingo takes 6h 15m
There are no direct flights from St. Louis to Santo Domingo. There are no popular flight routes from St. Louis to Santo Domingo.
Search flight deals

  • How far is Lambert-St Louis to Santo Domingo Las Americas by plane?

    The straight-line distance from Lambert-St Louis to Santo Domingo Las Americas is 1847.1 mi. A reasonable flight in good conditions will take 6h 15m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santo Domingo?

Best airlines flying from St. Louis to Santo Domingo

Compare and see reviews for airlines that fly from St. Louis to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $514Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $529Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Why should I use momondo to find a flight deal from St. Louis to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

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Yes. momondo can track prices for St. Louis to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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