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Cheap flights from St. Louis to Santo Domingo from $192

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santo Domingo departing on 5/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:33 pm - 1:39 pm
STL
-
SDQ
42h 06m
2 stops
Frontier Logo
10:58 am - 1:55 pm
SDQ
-
STL
51h 57m
2 stops
$485Frontier
Thu, May 28 - Thu, Jun 4
Frontier Logo
8:08 pm - 10:45 am
STL
-
SDQ
13h 37m
2 stops
Frontier Logo
12:21 pm - 5:30 pm
SDQ
-
STL
30h 09m
2 stops
$551Frontier
Mon, Jun 8 - Sat, Jun 13
American Airlines Logo
5:40 pm - 12:45 pm
STL
-
SDQ
18h 05m
1 stop
American Airlines Logo
7:39 pm - 10:45 am
SDQ
-
STL
16h 06m
1 stop
$590American Airlines
Wed, May 27 - Thu, Aug 6
American Airlines Logo
5:08 am - 6:35 pm
STL
-
SDQ
12h 27m
2 stops
American Airlines Logo
7:39 pm - 10:45 am
SDQ
-
STL
16h 06m
1 stop
$595American Airlines
Wed, May 27 - Thu, Aug 6
American Airlines Logo
6:19 pm - 9:27 am
STL
-
SDQ
14h 08m
1 stop
American Airlines Logo
8:00 am - 11:12 pm
SDQ
-
STL
16h 12m
1 stop
$610American Airlines
Sat, Aug 1 - Wed, Sep 30
American Airlines Logo
2:55 pm - 9:25 am
STL
-
SDQ
17h 30m
2 stops
American Airlines Logo
7:39 pm - 10:45 am
SDQ
-
STL
16h 06m
1 stop
$615American Airlines
Wed, Aug 19 - Mon, Aug 24
American Airlines Logo
5:48 pm - 12:57 pm
STL
-
SDQ
18h 09m
1 stop
American Airlines Logo
4:24 pm - 10:45 am
SDQ
-
STL
19h 21m
1 stop
$623American Airlines
Mon, Jul 6 - Mon, Aug 10
American Airlines Logo
5:00 am - 6:39 pm
STL
-
SDQ
12h 39m
1 stop
American Airlines Logo
4:24 pm - 10:45 am
SDQ
-
STL
19h 21m
1 stop
$630American Airlines
Tue, Aug 11 - Sun, Aug 16
American Airlines Logo
6:00 am - 6:39 pm
STL
-
SDQ
11h 39m
2 stops
American Airlines Logo
4:24 pm - 10:45 am
SDQ
-
STL
19h 21m
1 stop
$634American Airlines
Tue, Aug 11 - Sun, Aug 16
American Airlines Logo
7:00 am - 6:35 pm
STL
-
SDQ
10h 35m
2 stops
American Airlines Logo
10:25 am - 11:23 pm
SDQ
-
STL
13h 58m
2 stops
$635American Airlines
Wed, May 27 - Thu, Aug 6

American Airlines flights from St. Louis to Santo Domingo

Our best American Airlines deals on St. Louis to Santo Domingo flight tickets
American Airlines
May 27
STL5:40 pmLambert-St Louis
18h 05m
1 stop
SDQ12:45 pmSanto Domingo Las Americas
Aug 6
SDQ7:39 pmSanto Domingo Las Americas
16h 06m
1 stop
STL10:45 amLambert-St Louis
$590
American Airlines
May 27
STL5:08 amLambert-St Louis
12h 27m
2 stops
SDQ6:35 pmSanto Domingo Las Americas
Aug 6
SDQ7:39 pmSanto Domingo Las Americas
16h 06m
1 stop
STL10:45 amLambert-St Louis
$595
American Airlines
Aug 1
STL6:19 pmLambert-St Louis
14h 08m
1 stop
SDQ9:27 amSanto Domingo Las Americas
Sep 30
SDQ8:00 amSanto Domingo Las Americas
16h 12m
1 stop
STL11:12 pmLambert-St Louis
$610

Frontier flights from St. Louis to Santo Domingo

Our best Frontier deals on St. Louis to Santo Domingo flight tickets
Frontier
May 28
STL6:33 pmLambert-St Louis
42h 06m
2 stops
SDQ1:39 pmSanto Domingo Las Americas
Jun 4
SDQ10:58 amSanto Domingo Las Americas
51h 57m
2 stops
STL1:55 pmLambert-St Louis
$485
Frontier
Jun 8
STL8:08 pmLambert-St Louis
13h 37m
2 stops
SDQ10:45 amSanto Domingo Las Americas
Jun 13
SDQ12:21 pmSanto Domingo Las Americas
30h 09m
2 stops
STL5:30 pmLambert-St Louis
$551
Frontier
Jun 8
STL8:08 pmLambert-St Louis
13h 37m
2 stops
SDQ10:45 amSanto Domingo Las Americas
Jun 13
SDQ12:21 pmSanto Domingo Las Americas
45h 31m
2 stops
STL8:52 amLambert-St Louis
$657

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 5/28

6:33 pm-1:39 pm

2 stops42h 06m

Santo Domingo Las Americas

Thu 6/4

10:58 am-1:55 pm

2 stops51h 57m

$485

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 6/8

8:08 pm-10:45 am

2 stops13h 37m

Santo Domingo Las Americas

Sat 6/13

12:21 pm-5:30 pm

2 stops30h 09m

$551

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 5/27

5:40 pm-12:45 pm

1 stop18h 05m

Santo Domingo Las Americas

Thu 8/6

7:39 pm-10:45 am

1 stop16h 06m

$590

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 5/27

5:08 am-6:35 pm

2 stops12h 27m

Santo Domingo Las Americas

Thu 8/6

7:39 pm-10:45 am

1 stop16h 06m

$595

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sat 8/1

6:19 pm-9:27 am

1 stop14h 08m

Santo Domingo Las Americas

Wed 9/30

8:00 am-11:12 pm

1 stop16h 12m

$610

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 8/19

2:55 pm-9:25 am

2 stops17h 30m

Santo Domingo Las Americas

Mon 8/24

7:39 pm-10:45 am

1 stop16h 06m

$615

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 7/6

5:48 pm-12:57 pm

1 stop18h 09m

Santo Domingo Las Americas

Mon 8/10

4:24 pm-10:45 am

1 stop19h 21m

$623

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/11

5:00 am-6:39 pm

1 stop12h 39m

Santo Domingo Las Americas

Sun 8/16

4:24 pm-10:45 am

1 stop19h 21m

$630

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/11

6:00 am-6:39 pm

2 stops11h 39m

Santo Domingo Las Americas

Sun 8/16

4:24 pm-10:45 am

1 stop19h 21m

$634
Quickest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 5/27

7:00 am-6:35 pm

2 stops10h 35m

Santo Domingo Las Americas

Thu 8/6

10:25 am-11:23 pm

2 stops13h 58m

$635

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from St. Louis to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until February to fly from St. Louis, when ticket prices are also cheap, with an average price of $580.

Can stopping save me money on St. Louis to Santo Domingo flights?

You could potentially save up to 21% on your flight if you consider stops on a St. Louis to Santo Domingo flight.

When to book flights from St. Louis to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santo Domingo (STL to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santo Domingo

Fastest flight time

6h 17m

Direct flights

None
The fastest flight from St. Louis to Santo Domingo takes 6h 17m
There are no direct flights from St. Louis to Santo Domingo. There are no popular flight routes from St. Louis to Santo Domingo.
Search flight deals

Frequently asked questions about flying from St. Louis to Santo Domingo

  • How far is Lambert-St Louis to Santo Domingo Las Americas by plane?

    The straight-line distance from Lambert-St Louis to Santo Domingo Las Americas is 1847.1 mi. A reasonable flight in good conditions will take 6h 17m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santo Domingo?

Best airlines flying from St. Louis to Santo Domingo

Compare and see reviews for airlines that fly from St. Louis to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $524Free CancellationRating
7.9
8,467 reviews
Search Delta flights
American AirlinesPriceFrom $529Free CancellationRating
7.1
11,677 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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