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Cheap flights from St. Louis to Santo Domingo from $291

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santo Domingo departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:05 am - 5:23 pm
STL
-
SDQ
10h 18m1 stop
American Airlines Logo
7:00 am - 10:05 pm
SDQ
-
STL
17h 05m1 stop
$518American Airlines
Tue, Feb 3 - Tue, Feb 24
Delta Logo
6:35 am - 7:14 pm
STL
-
SDQ
10h 39m2 stops
Delta Logo
7:30 am - 8:43 pm
SDQ
-
STL
15h 13m2 stops
$522Delta
Tue, Feb 3 - Tue, Feb 24
American Airlines Logo
10:53 am - 7:55 pm
STL
-
SDQ
8h 02m1 stop
American Airlines Logo
5:00 pm - 11:59 pm
SDQ
-
STL
7h 59m1 stop
$533American Airlines
Wed, Jun 3 - Sun, Jun 7
American Airlines Logo
6:04 am - 5:55 pm
STL
-
SDQ
10h 51m2 stops
American Airlines Logo
5:00 pm - 11:59 pm
SDQ
-
STL
7h 59m1 stop
$537American Airlines
Wed, Jun 3 - Sun, Jun 7
American Airlines Logo
6:20 pm - 8:41 am
STL
-
SDQ
13h 21m1 stop
American Airlines Logo
6:00 am - 9:51 pm
SDQ
-
STL
16h 51m1 stop
$538American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
6:20 pm - 8:41 am
STL
-
SDQ
13h 21m1 stop
American Airlines Logo
6:00 am - 5:13 pm
SDQ
-
STL
12h 13m2 stops
$542American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
6:20 pm - 8:41 am
STL
-
SDQ
13h 21m1 stop
American Airlines Logo
6:00 am - 5:13 pm
SDQ
-
STL
12h 13m2 stops
$594American Airlines
Fri, Mar 27 - Sat, Apr 4
American Airlines Logo
5:30 am - 10:00 pm
STL
-
SDQ
14h 30m1 stop
American Airlines Logo
7:00 am - 10:44 pm
SDQ
-
STL
17h 44m1 stop
$613American Airlines
Mon, Dec 29 - Mon, Jan 12
American Airlines Logo
6:04 am - 5:55 pm
STL
-
SDQ
10h 51m2 stops
American Airlines Logo
5:00 pm - 7:59 am
SDQ
-
STL
15h 59m2 stops
$627American Airlines
Wed, Jun 3 - Sun, Jun 7
American Airlines Logo
11:41 am - 10:58 pm
STL
-
SDQ
10h 17m2 stops
American Airlines Logo
6:00 am - 5:13 pm
SDQ
-
STL
12h 13m2 stops
$632American Airlines
Fri, Mar 27 - Sat, Apr 4

United Airlines flights from St. Louis to Santo Domingo

Our best United Airlines deals on St. Louis to Santo Domingo flight tickets
United Airlines
Feb 1
STL9:57 amLambert-St Louis
11h 49m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ2:53 pmSanto Domingo Las Americas
11h 06m
1 stop
STL11:59 pmLambert-St Louis
$682
Find similar
United Airlines
Feb 1
STL11:22 amLambert-St Louis
10h 24m
1 stop
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ4:18 pmSanto Domingo Las Americas
9h 41m
1 stop
STL11:59 pmLambert-St Louis
$713
Find similar
United Airlines
Feb 1
STL8:05 amLambert-St Louis
13h 41m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ6:00 amSanto Domingo Las Americas
13h 43m
2 stops
STL5:43 pmLambert-St Louis
$717
Find similar

American Airlines flights from St. Louis to Santo Domingo

Our best American Airlines deals on St. Louis to Santo Domingo flight tickets
American Airlines
Feb 3
STL5:05 amLambert-St Louis
10h 18m
1 stop
SDQ5:23 pmSanto Domingo Las Americas
Feb 24
SDQ7:00 amSanto Domingo Las Americas
17h 05m
1 stop
STL10:05 pmLambert-St Louis
$518
Find similar
American Airlines
Jun 3
STL10:53 amLambert-St Louis
8h 02m
1 stop
SDQ7:55 pmSanto Domingo Las Americas
Jun 7
SDQ5:00 pmSanto Domingo Las Americas
7h 59m
1 stop
STL11:59 pmLambert-St Louis
$533
Find similar
American Airlines
Jun 3
STL6:04 amLambert-St Louis
10h 51m
2 stops
SDQ5:55 pmSanto Domingo Las Americas
Jun 7
SDQ5:00 pmSanto Domingo Las Americas
7h 59m
1 stop
STL11:59 pmLambert-St Louis
$537
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

5:05 am-5:23 pm

1 stop10h 18m

Santo Domingo Las Americas

Tue 2/24

7:00 am-10:05 pm

1 stop17h 05m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

6:35 am-7:14 pm

2 stops10h 39m

Santo Domingo Las Americas

Tue 2/24

7:30 am-8:43 pm

2 stops15h 13m

$522

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 6/3

10:53 am-7:55 pm

1 stop8h 02m

Santo Domingo Las Americas

Sun 6/7

5:00 pm-11:59 pm

1 stop7h 59m

$533

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 6/3

6:04 am-5:55 pm

2 stops10h 51m

Santo Domingo Las Americas

Sun 6/7

5:00 pm-11:59 pm

1 stop7h 59m

$537

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:41 am

1 stop13h 21m

Santo Domingo Las Americas

Sat 4/4

6:00 am-9:51 pm

1 stop16h 51m

$538

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:41 am

1 stop13h 21m

Santo Domingo Las Americas

Sat 4/4

6:00 am-5:13 pm

2 stops12h 13m

$542

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:41 am

1 stop13h 21m

Santo Domingo Las Americas

Sat 4/4

6:00 am-5:13 pm

2 stops12h 13m

$594

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 12/29

5:30 am-10:00 pm

1 stop14h 30m

Santo Domingo Las Americas

Mon 1/12

7:00 am-10:44 pm

1 stop17h 44m

$613

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 6/3

6:04 am-5:55 pm

2 stops10h 51m

Santo Domingo Las Americas

Sun 6/7

5:00 pm-7:59 am

2 stops15h 59m

$627

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

11:41 am-10:58 pm

2 stops10h 17m

Santo Domingo Las Americas

Sat 4/4

6:00 am-5:13 pm

2 stops12h 13m

$632

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from St. Louis to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until September to fly from St. Louis, when ticket prices are also cheap, with an average price of $533.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $486. The most expensive day to fly to Santo Domingo is Friday, with ticket prices averaging around $765.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $445. Try not to purchase tickets in the morning because they tend to be around $610. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from St. Louis to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santo Domingo (STL to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santo Domingo

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from St. Louis to Santo Domingo takes 6h 15m
There are no direct flights from St. Louis to Santo Domingo. There are no popular flight routes from St. Louis to Santo Domingo.
Search flight deals

  • How far is Lambert-St Louis to Santo Domingo Las Americas by plane?

    The straight-line distance from Lambert-St Louis to Santo Domingo Las Americas is 1847.1 mi. A reasonable flight in good conditions will take 6h 15m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santo Domingo?

Best airlines flying from St. Louis to Santo Domingo

Compare and see reviews for airlines that fly from St. Louis to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $514Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $517Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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