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Cheap flights from South Carolina to Santiago de los Caballeros from $191

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago de los Caballeros departing on 7/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
3:10 pm - 11:51 pm
CLT
-
STI
8h 41m
1 stop
JetBlue Logo
5:01 am - 2:15 pm
STI
-
CLT
9h 14m
1 stop
$414JetBlue
Sat, Jul 11 - Thu, Jul 16
Frontier Logo
1:09 pm - 9:54 am
CLT
-
STI
20h 45m
1 stop
Frontier Logo
11:09 am - 2:52 pm
STI
-
CLT
27h 43m
1 stop
$424Frontier
Wed, Jun 17 - Sun, Jun 21
JetBlue Logo
3:10 pm - 11:51 pm
CLT
-
STI
8h 41m
1 stop
JetBlue Logo
5:01 am - 2:15 pm
STI
-
CLT
9h 14m
1 stop
$441JetBlue
Sat, Aug 8 - Thu, Aug 13
American Airlines Logo
7:50 pm - 2:37 pm
CHS
-
STI
18h 47m
2 stops
American Airlines Logo
1:45 pm - 12:29 pm
STI
-
CHS
22h 44m
1 stop
$445American Airlines
Sat, Jun 27 - Sun, Jul 5
JetBlue Logo
3:10 pm - 11:51 pm
CLT
-
STI
8h 41m
1 stop
JetBlue Logo
5:01 am - 2:15 pm
STI
-
CLT
9h 14m
1 stop
$446JetBlue
Sat, Jul 11 - Wed, Jul 15
American Airlines Logo
6:42 pm - 12:12 pm
CHS
-
STI
17h 30m
1 stop
American Airlines Logo
7:00 am - 10:22 am
STI
-
CHS
27h 22m
1 stop
$465American Airlines
Wed, Jun 3 - Fri, Jul 3
American Airlines Logo
6:37 am - 9:13 pm
CHS
-
STI
14h 36m
2 stops
American Airlines Logo
7:00 am - 10:22 am
STI
-
CHS
27h 22m
1 stop
$470American Airlines
Wed, Jun 3 - Fri, Jul 3
Delta Logo
5:44 am - 1:59 am
GSP
-
STI
20h 15m
2 stops
Delta Logo
8:59 pm - 4:10 pm
STI
-
GSP
19h 11m
2 stops
$615Delta
Wed, Jun 17 - Thu, Jul 2
Delta Logo
6:45 am - 1:59 am
GSP
-
STI
19h 14m
2 stops
Delta Logo
8:59 pm - 11:59 pm
STI
-
GSP
27h 00m
2 stops
$681Delta
Tue, Jun 16 - Fri, Jun 26
United Airlines Logo
11:18 am - 10:52 pm
CAE
-
STI
11h 34m
1 stop
United Airlines Logo
2:07 pm - 10:39 am
STI
-
CAE
20h 32m
1 stop
$1,407United Airlines
Fri, Jun 12 - Sun, Jun 21

JetBlue flights from South Carolina to Santiago de los Caballeros

Our best JetBlue deals on South Carolina to Santiago de los Caballeros flight tickets
JetBlue
Aug 27
CLT9:00 amCharlotte Douglas
5h 36m
1 stop
STI2:36 pmSantiago de los Caballeros
Sep 8
STI5:01 amSantiago de los Caballeros
9h 14m
1 stop
CLT2:15 pmCharlotte Douglas
$347
JetBlue
Aug 27
CLT9:00 amCharlotte Douglas
5h 36m
1 stop
STI2:36 pmSantiago de los Caballeros
Sep 8
STI3:51 pmSantiago de los Caballeros
7h 09m
1 stop
CLT11:00 pmCharlotte Douglas
$379
JetBlue
Aug 29
CLT3:10 pmCharlotte Douglas
8h 41m
1 stop
STI11:51 pmSantiago de los Caballeros
Sep 2
STI3:51 pmSantiago de los Caballeros
7h 09m
1 stop
CLT11:00 pmCharlotte Douglas
$384

American Airlines flights from South Carolina to Santiago de los Caballeros

Our best American Airlines deals on South Carolina to Santiago de los Caballeros flight tickets
American Airlines
Jun 27
CHS7:50 pmCharleston
18h 47m
2 stops
STI2:37 pmSantiago de los Caballeros
Jul 5
STI1:45 pmSantiago de los Caballeros
22h 44m
1 stop
CHS12:29 pmCharleston
$445
American Airlines
Jun 3
CHS6:42 pmCharleston
17h 30m
1 stop
STI12:12 pmSantiago de los Caballeros
Jul 3
STI7:00 amSantiago de los Caballeros
27h 22m
1 stop
CHS10:22 amCharleston
$465
American Airlines
Jun 3
CHS6:37 amCharleston
14h 36m
2 stops
STI9:13 pmSantiago de los Caballeros
Jul 3
STI7:00 amSantiago de los Caballeros
27h 22m
1 stop
CHS10:22 amCharleston
$470

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Sat 7/11

3:10 pm-11:51 pm

1 stop8h 41m

Santiago de los Caballeros

Thu 7/16

5:01 am-2:15 pm

1 stop9h 14m

$414

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Wed 6/17

1:09 pm-9:54 am

1 stop20h 45m

Santiago de los Caballeros

Sun 6/21

11:09 am-2:52 pm

1 stop27h 43m

$424

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Sat 8/8

3:10 pm-11:51 pm

1 stop8h 41m

Santiago de los Caballeros

Thu 8/13

5:01 am-2:15 pm

1 stop9h 14m

$441

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 6/27

7:50 pm-2:37 pm

2 stops18h 47m

Santiago de los Caballeros

Sun 7/5

1:45 pm-12:29 pm

1 stop22h 44m

$445

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Sat 7/11

3:10 pm-11:51 pm

1 stop8h 41m

Santiago de los Caballeros

Wed 7/15

5:01 am-2:15 pm

1 stop9h 14m

$446

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Wed 6/3

6:42 pm-12:12 pm

1 stop17h 30m

Santiago de los Caballeros

Fri 7/3

7:00 am-10:22 am

1 stop27h 22m

$465

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Wed 6/3

6:37 am-9:13 pm

2 stops14h 36m

Santiago de los Caballeros

Fri 7/3

7:00 am-10:22 am

1 stop27h 22m

$470

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Wed 6/17

5:44 am-1:59 am

2 stops20h 15m

Santiago de los Caballeros

Thu 7/2

8:59 pm-4:10 pm

2 stops19h 11m

$615

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Tue 6/16

6:45 am-1:59 am

2 stops19h 14m

Santiago de los Caballeros

Fri 6/26

8:59 pm-11:59 pm

2 stops27h 00m

$681

ColumbiaSantiago de los Caballeros

CAE - STI

CAESTI

Columbia Metropolitan

Fri 6/12

11:18 am-10:52 pm

1 stop11h 34m

Santiago de los Caballeros

Sun 6/21

2:07 pm-10:39 am

1 stop20h 32m

$1,407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from South Carolina to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Santiago de los Caballeros flights?

You could potentially save up to 6% on your flight if you consider stops on a South Carolina to Santiago de los Caballeros flight.

Cheap South Carolina to Santiago de los Caballeros flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago de los Caballeros

Fastest flight time

4h 46m

Direct flights

None
The fastest flight from South Carolina to Santiago de los Caballeros takes 4h 46m
There are no direct flights from South Carolina to Santiago de los Caballeros. There are no popular flight routes from South Carolina to Santiago de los Caballeros.
Search flight deals

Frequently asked questions about flying from South Carolina to Santiago de los Caballeros

  • When did momondo last update prices for flights from South Carolina to Santiago de los Caballeros Airport?

    Prices for flights from South Carolina to Santiago de los Caballeros Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from South Carolina to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago de los Caballeros

Compare and see reviews for airlines that fly from South Carolina to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $458Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Carolina to Santiago de los Caballeros for you.

Can I find flights from South Carolina to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. All flights to Santiago de los Caballeros from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Santiago de los Caballeros?

momondo helps you find the best flight between South Carolina and Santiago de los Caballeros by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago de los Caballeros from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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