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Cheap flights from South Carolina to Santiago de los Caballeros from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago de los Caballeros departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:04 am - 2:02 pm
CLT
-
STI
4h 58m
1 stop
Spirit Airlines Logo
3:17 pm - 11:40 pm
STI
-
CLT
8h 23m
1 stop
$298Spirit Airlines
Do, Apr 30 - Sa, Mai 9
Spirit Airlines Logo
9:00 pm - 1:49 am
CLT
-
STI
4h 49m
1 stop
Spirit Airlines Logo
3:07 pm - 8:49 pm
STI
-
CLT
5h 42m
1 stop
$299Spirit Airlines
So, Apr 12 - Sa, Apr 25
JetBlue Logo
8:34 pm - 8:02 am
CHS
-
STI
11h 28m
1 stop
JetBlue Logo
8:31 am - 7:34 pm
STI
-
CHS
11h 03m
1 stop
$378JetBlue
Sa, Apr 25 - Sa, Mai 2
JetBlue Logo
5:59 pm - 1:39 am
CHS
-
STI
7h 40m
1 stop
JetBlue Logo
8:57 am - 7:17 pm
STI
-
CHS
10h 20m
1 stop
$379JetBlue
Fr, Mai 15 - So, Mai 17
Delta Logo
5:55 pm - 12:59 am
CHS
-
STI
7h 04m
1 stop
Delta Logo
8:59 pm - 12:12 pm
STI
-
CHS
15h 13m
1 stop
$383Delta
Sa, Mai 16 - Mo, Mai 18
Delta Logo
5:55 pm - 12:59 am
CHS
-
STI
7h 04m
1 stop
Delta Logo
8:59 pm - 3:49 pm
STI
-
CHS
18h 50m
2 stops
$387Delta
Sa, Mai 16 - Mo, Mai 18
American Airlines Logo
4:46 pm - 12:23 pm
CHS
-
STI
19h 37m
2 stops
American Airlines Logo
1:32 pm - 8:31 am
STI
-
CHS
18h 59m
2 stops
$392American Airlines
Fr, Mai 15 - So, Mai 17
American Airlines Logo
8:21 pm - 12:23 pm
CHS
-
STI
16h 02m
2 stops
American Airlines Logo
1:32 pm - 10:34 am
STI
-
CHS
21h 02m
1 stop
$400American Airlines
Fr, Mai 15 - So, Mai 17
Multiple Airlines Logo
3:48 pm - 1:50 pm
GSP
-
STI
22h 02m
1 stop
Multiple Airlines Logo
2:46 pm - 2:25 pm
STI
-
GSP
23h 39m
2 stops
$484Multiple Airlines
Mi, Jul 1 - So, Jul 5
Multiple Airlines Logo
3:48 pm - 1:50 pm
GSP
-
STI
22h 02m
1 stop
Multiple Airlines Logo
2:46 pm - 2:41 pm
STI
-
GSP
23h 55m
1 stop
$493Multiple Airlines
Mi, Jul 1 - So, Jul 5

Spirit Airlines flights from South Carolina to Santiago de los Caballeros

Our best Spirit Airlines deals on South Carolina to Santiago de los Caballeros flight tickets
Spirit Airlines
Apr 30
CLT9:04 amCharlotte Douglas
4h 58m
1 stop
STI2:02 pmSantiago de los Caballeros
May 9
STI3:17 pmSantiago de los Caballeros
8h 23m
1 stop
CLT11:40 pmCharlotte Douglas
$298
Spirit Airlines
Apr 12
CLT9:00 pmCharlotte Douglas
4h 49m
1 stop
STI1:49 amSantiago de los Caballeros
Apr 25
STI3:07 pmSantiago de los Caballeros
5h 42m
1 stop
CLT8:49 pmCharlotte Douglas
$299
Spirit Airlines
Apr 10
CLT6:00 amCharlotte Douglas
8h 23m
1 stop
STI2:23 pmSantiago de los Caballeros
Apr 17
STI3:07 pmSantiago de los Caballeros
5h 42m
1 stop
CLT8:49 pmCharlotte Douglas
$309

JetBlue flights from South Carolina to Santiago de los Caballeros

Our best JetBlue deals on South Carolina to Santiago de los Caballeros flight tickets
JetBlue
Apr 25
CHS8:34 pmCharleston
11h 28m
1 stop
STI8:02 amSantiago de los Caballeros
May 2
STI8:31 amSantiago de los Caballeros
11h 03m
1 stop
CHS7:34 pmCharleston
$378
JetBlue
May 15
CHS5:59 pmCharleston
7h 40m
1 stop
STI1:39 amSantiago de los Caballeros
May 17
STI8:57 amSantiago de los Caballeros
10h 20m
1 stop
CHS7:17 pmCharleston
$379
JetBlue
May 15
CHS5:59 pmCharleston
7h 40m
1 stop
STI1:39 amSantiago de los Caballeros
May 17
STI6:00 amSantiago de los Caballeros
10h 57m
1 stop
CHS4:57 pmCharleston
$380

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated März 30, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Do 4/30

9:04 am-2:02 pm

1 stop4h 58m

Santiago de los Caballeros

Sa 5/9

3:17 pm-11:40 pm

1 stop8h 23m

$298
Quickest round-trip

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

So 4/12

9:00 pm-1:49 am

1 stop4h 49m

Santiago de los Caballeros

Sa 4/25

3:07 pm-8:49 pm

1 stop5h 42m

$299

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sa 4/25

8:34 pm-8:02 am

1 stop11h 28m

Santiago de los Caballeros

Sa 5/2

8:31 am-7:34 pm

1 stop11h 03m

$378

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fr 5/15

5:59 pm-1:39 am

1 stop7h 40m

Santiago de los Caballeros

So 5/17

8:57 am-7:17 pm

1 stop10h 20m

$379

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sa 5/16

5:55 pm-12:59 am

1 stop7h 04m

Santiago de los Caballeros

Mo 5/18

8:59 pm-12:12 pm

1 stop15h 13m

$383

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sa 5/16

5:55 pm-12:59 am

1 stop7h 04m

Santiago de los Caballeros

Mo 5/18

8:59 pm-3:49 pm

2 stops18h 50m

$387

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fr 5/15

4:46 pm-12:23 pm

2 stops19h 37m

Santiago de los Caballeros

So 5/17

1:32 pm-8:31 am

2 stops18h 59m

$392

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fr 5/15

8:21 pm-12:23 pm

2 stops16h 02m

Santiago de los Caballeros

So 5/17

1:32 pm-10:34 am

1 stop21h 02m

$400

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Mi 7/1

3:48 pm-1:50 pm

1 stop22h 02m

Santiago de los Caballeros

So 7/5

2:46 pm-2:25 pm

2 stops23h 39m

$484

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Mi 7/1

3:48 pm-1:50 pm

1 stop22h 02m

Santiago de los Caballeros

So 7/5

2:46 pm-2:41 pm

1 stop23h 55m

$493

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from South Carolina to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Santiago de los Caballeros flights?

You could potentially save up to 13% on your flight if you consider stops on a South Carolina to Santiago de los Caballeros flight.

Cheap South Carolina to Santiago de los Caballeros flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago de los Caballeros

Fastest flight time

4h 58m

Direct flights

None
The fastest flight from South Carolina to Santiago de los Caballeros takes 4h 58m
There are no direct flights from South Carolina to Santiago de los Caballeros. There are no popular flight routes from South Carolina to Santiago de los Caballeros.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santiago de los Caballeros Airport?

    Prices for flights from South Carolina to Santiago de los Caballeros Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from South Carolina to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago de los Caballeros

Compare and see reviews for airlines that fly from South Carolina to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $438Free CancellationRating
7.1
11,531 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Carolina to Santiago de los Caballeros for you.

Can I find flights from South Carolina to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. All flights to Santiago de los Caballeros from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Santiago de los Caballeros?

momondo helps you find the best flight between South Carolina and Santiago de los Caballeros by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago de los Caballeros from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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