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Cheap flights from South Carolina to Santiago de los Caballeros from $138

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago de los Caballeros departing on 12/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
2:58 pm - 2:42 amCLT-STI
10h 44m1 stop
Spirit Airlines Logo
3:43 am - 9:39 amSTI-CLT
6h 56m1 stop
$299Spirit Airlines
Find Deal
Thu, Dec 4 - Fri, Dec 5
Spirit Airlines Logo
12:59 pm - 2:42 amCLT-STI
12h 43m2 stops
Spirit Airlines Logo
1:01 pm - 11:59 pmSTI-CLT
11h 58m1 stop
$339Spirit Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
Delta Logo
6:00 am - 11:27 pmCHS-STI
17h 27m1 stop
Delta Logo
6:00 am - 4:47 pmSTI-CHS
10h 47m1 stop
$348Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
Delta Logo
12:15 pm - 11:27 pmCHS-STI
11h 12m2 stops
Delta Logo
6:00 am - 4:47 pmSTI-CHS
10h 47m1 stop
$352Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
American Airlines Logo
6:00 am - 9:46 pmCHS-STI
14h 46m1 stop
American Airlines Logo
4:33 pm - 9:48 amSTI-CHS
18h 15m2 stops
$357American Airlines
Find Deal
Thu, Jan 15 - Sun, Jan 25
Multiple Airlines Logo
3:35 pm - 12:22 pmCLT-STI
19h 47m2 stops
Multiple Airlines Logo
1:17 pm - 2:06 pmSTI-CLT
25h 49m1 stop
$387Multiple Airlines
Find Deal
Thu, Nov 20 - Mon, Dec 1
Multiple Airlines Logo
10:22 am - 12:22 pmCLT-STI
25h 00m2 stops
Multiple Airlines Logo
1:17 pm - 2:06 pmSTI-CLT
25h 49m1 stop
$394Multiple Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 1
American Airlines Logo
6:00 am - 3:32 pmCHS-STI
8h 32m1 stop
American Airlines Logo
6:00 am - 11:55 pmSTI-CHS
18h 55m1 stop
$428American Airlines
Find Deal
Thu, Jan 15 - Sun, Jan 25
JetBlue Logo
6:45 am - 8:34 pmCHS-STI
12h 49m1 stop
JetBlue Logo
3:00 am - 1:48 pmSTI-CHS
11h 48m1 stop
$436JetBlue
Find Deal
Tue, Dec 9 - Wed, Dec 10
JetBlue Logo
10:10 am - 12:23 amCHS-STI
13h 13m1 stop
JetBlue Logo
4:10 am - 9:20 amSTI-CHS
30h 10m1 stop
$516JetBlue
Find Deal
Thu, Jan 15 - Sat, Jan 24

Delta flights from South Carolina to Santiago de los Caballeros

Our best Delta deals on South Carolina to Santiago de los Caballeros flight tickets
Delta
Mar 9
CHS6:00 amCharleston
17h 27m
1 stop
STI11:27 pmSantiago de los Caballeros
Mar 11
STI6:00 amSantiago de los Caballeros
10h 47m
1 stop
CHS4:47 pmCharleston
$348
Find similar
Delta
Mar 9
CHS12:15 pmCharleston
11h 12m
2 stops
STI11:27 pmSantiago de los Caballeros
Mar 11
STI6:00 amSantiago de los Caballeros
10h 47m
1 stop
CHS4:47 pmCharleston
$352
Find similar
Delta
Mar 9
CHS12:15 pmCharleston
11h 12m
2 stops
STI11:27 pmSantiago de los Caballeros
Mar 11
STI6:00 amSantiago de los Caballeros
10h 47m
1 stop
CHS4:47 pmCharleston
$375
Find similar

Spirit Airlines flights from South Carolina to Santiago de los Caballeros

Our best Spirit Airlines deals on South Carolina to Santiago de los Caballeros flight tickets
Spirit Airlines
Dec 4
CLT2:58 pmCharlotte Douglas
10h 44m
1 stop
STI2:42 amSantiago de los Caballeros
Dec 5
STI3:43 amSantiago de los Caballeros
6h 56m
1 stop
CLT9:39 amCharlotte Douglas
$299
Find similar
Spirit Airlines
Dec 6
CLT12:59 pmCharlotte Douglas
12h 43m
2 stops
STI2:42 amSantiago de los Caballeros
Dec 13
STI1:01 pmSantiago de los Caballeros
11h 58m
1 stop
CLT11:59 pmCharlotte Douglas
$339
Find similar
Spirit Airlines
Feb 3
CLT7:00 amCharlotte Douglas
7h 33m
1 stop
STI3:33 pmSantiago de los Caballeros
Mar 3
STI4:40 pmSantiago de los Caballeros
9h 00m
1 stop
CLT12:40 amCharlotte Douglas
$343
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Thu 12/4

2:58 pm-2:42 am

1 stop10h 44m

Santiago de los Caballeros

Fri 12/5

3:43 am-9:39 am

1 stop6h 56m

$299

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Sat 12/6

12:59 pm-2:42 am

2 stops12h 43m

Santiago de los Caballeros

Sat 12/13

1:01 pm-11:59 pm

1 stop11h 58m

$339

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

6:00 am-11:27 pm

1 stop17h 27m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:47 pm

1 stop10h 47m

$348

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

12:15 pm-11:27 pm

2 stops11h 12m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:47 pm

1 stop10h 47m

$352

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Thu 1/15

6:00 am-9:46 pm

1 stop14h 46m

Santiago de los Caballeros

Sun 1/25

4:33 pm-9:48 am

2 stops18h 15m

$357

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Thu 11/20

3:35 pm-12:22 pm

2 stops19h 47m

Santiago de los Caballeros

Mon 12/1

1:17 pm-2:06 pm

1 stop25h 49m

$387

CharlotteSantiago de los Caballeros

CLT - STI

CLTSTI

Charlotte Douglas

Thu 11/27

10:22 am-12:22 pm

2 stops25h 00m

Santiago de los Caballeros

Mon 12/1

1:17 pm-2:06 pm

1 stop25h 49m

$394

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Thu 1/15

6:00 am-3:32 pm

1 stop8h 32m

Santiago de los Caballeros

Sun 1/25

6:00 am-11:55 pm

1 stop18h 55m

$428

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Tue 12/9

6:45 am-8:34 pm

1 stop12h 49m

Santiago de los Caballeros

Wed 12/10

3:00 am-1:48 pm

1 stop11h 48m

$436

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Thu 1/15

10:10 am-12:23 am

1 stop13h 13m

Santiago de los Caballeros

Sat 1/24

4:10 am-9:20 am

1 stop30h 10m

$516

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from South Carolina to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from South Carolina to Santiago de los Caballeros is on a Saturday when prices can be found for as low as $501. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Santiago de los Caballeros for around $946.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest South Carolina to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $386. In the morning is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $585 per ticket.

Can stopping save me money on South Carolina to Santiago de los Caballeros flights?

You could potentially save up to 6% on your flight if you consider stops on a South Carolina to Santiago de los Caballeros flight.

Cheap South Carolina to Santiago de los Caballeros flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago de los Caballeros

Direct flights

None
There are no direct flights from South Carolina to Santiago de los Caballeros. There are no popular flight routes from South Carolina to Santiago de los Caballeros.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santiago de los Caballeros Airport?

    Prices for flights from South Carolina to Santiago de los Caballeros Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from South Carolina to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago de los Caballeros

Compare and see reviews for airlines that fly from South Carolina to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $371Free CancellationRating
7.2
2,907 reviews
Search JetBlue flights
American AirlinesPriceFrom $458Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Carolina to Santiago de los Caballeros for you.

Can I find flights from South Carolina to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. All flights to Santiago de los Caballeros from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Santiago de los Caballeros?

momondo helps you find the best flight between South Carolina and Santiago de los Caballeros by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago de los Caballeros from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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