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Cheap flights from South Carolina to Santiago from $319

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Santiago

Cheap round-trip flights

Multiple Airlines Logo
1:49 pm - 12:15 pmCLT-SCL
21h 26m3 stops
Multiple Airlines Logo
5:12 am - 12:59 amSCL-CLT
21h 47m2 stops
$593Multiple Airlines
Find Deal
lun., oct. 27 - lun., nov. 10
Multiple Airlines Logo
10:42 pm - 10:15 pmCLT-SCL
21h 33m2 stops
Multiple Airlines Logo
10:50 am - 9:57 pmSCL-CLT
13h 07m1 stop
$607Multiple Airlines
Find Deal
lun., nov. 3 - lun., nov. 17
LATAM Airlines Logo
1:15 pm - 5:55 amCLT-SCL
15h 40m1 stop
LATAM Airlines Logo
10:40 pm - 1:56 pmSCL-CLT
16h 16m1 stop
$722LATAM Airlines
Find Deal
lun., mar. 9 - lun., mar. 16
LATAM Airlines Logo
2:20 pm - 5:35 amCLT-SCL
14h 15m2 stops
LATAM Airlines Logo
10:40 pm - 1:56 pmSCL-CLT
16h 16m1 stop
$726LATAM Airlines
Find Deal
lun., mar. 9 - lun., mar. 16
American Airlines Logo
3:16 pm - 7:55 amCHS-SCL
14h 39m1 stop
American Airlines Logo
11:15 pm - 2:38 pmSCL-CHS
17h 23m1 stop
$901American Airlines
Find Deal
jue., nov. 13 - mié., nov. 26
Delta Logo
12:53 pm - 6:55 amCHS-SCL
16h 02m1 stop
Delta Logo
12:55 am - 11:56 pmSCL-CHS
25h 01m2 stops
$904Delta
Find Deal
jue., nov. 13 - mar., nov. 25
American Airlines Logo
2:29 pm - 7:55 amCHS-SCL
15h 26m2 stops
American Airlines Logo
10:25 pm - 12:12 pmSCL-CHS
15h 47m2 stops
$905American Airlines
Find Deal
jue., nov. 13 - mié., nov. 26
United Airlines Logo
5:05 pm - 8:50 amCHS-SCL
13h 45m1 stop
United Airlines Logo
10:45 pm - 4:16 pmSCL-CHS
19h 31m1 stop
$954United Airlines
Find Deal
mié., nov. 5 - mié., nov. 12
United Airlines Logo
6:15 am - 8:50 amCHS-SCL
24h 35m2 stops
United Airlines Logo
10:45 pm - 7:00 pmSCL-CHS
22h 15m2 stops
$958United Airlines
Find Deal
mié., nov. 5 - mié., nov. 12
Delta Logo
7:00 am - 5:45 amSAV-SCL
21h 45m1 stop
Delta Logo
8:15 am - 11:58 pmSCL-SAV
16h 43m2 stops
$974Delta
Find Deal
mié., oct. 22 - mié., oct. 29

American Airlines flights from South Carolina to Santiago

Our best American Airlines deals on South Carolina to Santiago flight tickets
American Airlines
Nov 13
CHS3:16 pmCharleston
14h 39m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Nov 26
SCL11:15 pmSantiago Arturo Merino Benitez
17h 23m
1 stop
CHS2:38 pmCharleston
$901
Find similar
American Airlines
Nov 13
CHS2:29 pmCharleston
15h 26m
2 stops
SCL7:55 amSantiago Arturo Merino Benitez
Nov 26
SCL10:25 pmSantiago Arturo Merino Benitez
15h 47m
2 stops
CHS12:12 pmCharleston
$905
Find similar
American Airlines
Oct 15
GSP4:46 pmGreenville
14h 14m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Oct 27
SCL9:15 pmSantiago Arturo Merino Benitez
19h 43m
1 stop
GSP3:58 pmGreenville
$1,104
Find similar

Delta flights from South Carolina to Santiago

Our best Delta deals on South Carolina to Santiago flight tickets
Delta
Nov 13
CHS12:53 pmCharleston
16h 02m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Nov 25
SCL12:55 amSantiago Arturo Merino Benitez
25h 01m
2 stops
CHS11:56 pmCharleston
$904
Find similar
Delta
Oct 22
SAV7:00 amSavannah/Hilton Head
21h 45m
1 stop
SCL5:45 amSantiago Arturo Merino Benitez
Oct 29
SCL8:15 amSantiago Arturo Merino Benitez
16h 43m
2 stops
SAV11:58 pmSavannah/Hilton Head
$974
Find similar
Delta
Oct 29
CHS12:54 pmCharleston
17h 46m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Nov 3
SCL12:55 amSantiago Arturo Merino Benitez
20h 03m
2 stops
CHS6:58 pmCharleston
$1,024
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 22, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 10/27

1:49 pm-12:15 pm

3 stops21h 26m

Santiago Arturo Merino Benitez

lun. 11/10

5:12 am-12:59 am

2 stops21h 47m

$593

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 11/3

10:42 pm-10:15 pm

2 stops21h 33m

Santiago Arturo Merino Benitez

lun. 11/17

10:50 am-9:57 pm

1 stop13h 07m

$607

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 3/9

1:15 pm-5:55 am

1 stop15h 40m

Santiago Arturo Merino Benitez

lun. 3/16

10:40 pm-1:56 pm

1 stop16h 16m

$722

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

lun. 3/9

2:20 pm-5:35 am

2 stops14h 15m

Santiago Arturo Merino Benitez

lun. 3/16

10:40 pm-1:56 pm

1 stop16h 16m

$726

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

jue. 11/13

3:16 pm-7:55 am

1 stop14h 39m

Santiago Arturo Merino Benitez

mié. 11/26

11:15 pm-2:38 pm

1 stop17h 23m

$901

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

jue. 11/13

12:53 pm-6:55 am

1 stop16h 02m

Santiago Arturo Merino Benitez

mar. 11/25

12:55 am-11:56 pm

2 stops25h 01m

$904

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

jue. 11/13

2:29 pm-7:55 am

2 stops15h 26m

Santiago Arturo Merino Benitez

mié. 11/26

10:25 pm-12:12 pm

2 stops15h 47m

$905

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

mié. 11/5

5:05 pm-8:50 am

1 stop13h 45m

Santiago Arturo Merino Benitez

mié. 11/12

10:45 pm-4:16 pm

1 stop19h 31m

$954

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

mié. 11/5

6:15 am-8:50 am

2 stops24h 35m

Santiago Arturo Merino Benitez

mié. 11/12

10:45 pm-7:00 pm

2 stops22h 15m

$958

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

mié. 10/22

7:00 am-5:45 am

1 stop21h 45m

Santiago Arturo Merino Benitez

mié. 10/29

8:15 am-11:58 pm

2 stops16h 43m

$974

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from South Carolina to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $722. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $1,089.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from South Carolina to Santiago when you can find flight prices for as low as $782. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $897 per ticket.

Can stopping save me money on South Carolina to Santiago flights?

You could potentially save up to 14% on your flight if you consider stops on a South Carolina to Santiago flight.

Cheap South Carolina to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago

Direct flights

None
There are no direct flights from South Carolina to Santiago. There are no popular flight routes from South Carolina to Santiago.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

    Prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from South Carolina to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago

Compare and see reviews for airlines that fly from South Carolina to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $532Free CancellationRating
7.9
7,971 reviews
Search Delta flights
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,851 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Santiago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Santiago?

momondo helps you find the best flight between South Carolina and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from South Carolina and alert you when they change.

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mié. 10/22
mié. 10/29
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