Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from South Carolina to Santiago from $272

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from South Carolina to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:57 pm - 10:15 pmCLT-SCL
30h 18m2 stops
Multiple Airlines Logo
11:25 pm - 12:41 pmSCL-CLT
15h 16m1 stop
$629Multiple Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
Multiple Airlines Logo
7:00 am - 12:15 pmCLT-SCL
27h 15m3 stops
Multiple Airlines Logo
12:30 pm - 7:10 pmSCL-CLT
32h 40m2 stops
$635Multiple Airlines
Find Deal
Sat, Dec 6 - Sat, Dec 13
Delta Logo
12:51 pm - 7:40 amCHS-SCL
16h 49m1 stop
Delta Logo
11:10 pm - 3:15 pmSCL-CHS
18h 05m1 stop
$664Delta
Find Deal
Thu, Dec 4 - Thu, Dec 11
LATAM Airlines Logo
12:51 pm - 5:35 amCHS-SCL
14h 44m2 stops
LATAM Airlines Logo
7:15 am - 11:50 pmSCL-CHS
18h 35m3 stops
$669LATAM Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
LATAM Airlines Logo
1:22 pm - 6:55 amCLT-SCL
15h 33m1 stop
LATAM Airlines Logo
11:30 pm - 1:28 pmSCL-CLT
15h 58m1 stop
$684LATAM Airlines
Find Deal
Thu, Dec 4 - Tue, Dec 9
Delta Logo
5:18 pm - 3:30 pmCHS-SCL
20h 12m2 stops
Delta Logo
11:10 pm - 12:07 pmSCL-CHS
14h 57m1 stop
$704Delta
Find Deal
Sat, Jan 31 - Thu, Feb 5
American Airlines Logo
6:55 pm - 9:00 amGSP-SCL
12h 05m1 stop
American Airlines Logo
11:55 pm - 6:25 pmSCL-GSP
20h 30m1 stop
$714American Airlines
Find Deal
Mon, Jan 12 - Mon, Feb 2
American Airlines Logo
10:32 am - 9:00 amGSP-SCL
20h 28m2 stops
American Airlines Logo
10:35 pm - 3:14 pmSCL-GSP
18h 39m2 stops
$719American Airlines
Find Deal
Mon, Jan 12 - Mon, Feb 2
United Airlines Logo
6:40 am - 8:50 amCLT-SCL
24h 10m2 stops
United Airlines Logo
10:45 pm - 9:39 pmSCL-CLT
24h 54m2 stops
$719United Airlines
Find Deal
Wed, Nov 26 - Mon, Dec 1
United Airlines Logo
6:45 am - 8:50 amCLT-SCL
24h 05m1 stop
United Airlines Logo
10:45 pm - 10:51 amSCL-CLT
14h 06m1 stop
$723United Airlines
Find Deal
Wed, Nov 26 - Mon, Dec 1

LATAM Airlines flights from South Carolina to Santiago

Our best LATAM Airlines deals on South Carolina to Santiago flight tickets
LATAM Airlines
Dec 4
CHS12:51 pmCharleston
14h 44m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Dec 11
SCL7:15 amSantiago Arturo Merino Benitez
18h 35m
3 stops
CHS11:50 pmCharleston
$669
Find similar
LATAM Airlines
Dec 4
CLT1:22 pmCharlotte Douglas
15h 33m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Dec 9
SCL11:30 pmSantiago Arturo Merino Benitez
15h 58m
1 stop
CLT1:28 pmCharlotte Douglas
$684
Find similar
LATAM Airlines
Dec 4
CLT5:10 pmCharlotte Douglas
18h 55m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Dec 9
SCL11:30 pmSantiago Arturo Merino Benitez
15h 58m
1 stop
CLT1:28 pmCharlotte Douglas
$699
Find similar

Air Canada flights from South Carolina to Santiago

Our best Air Canada deals on South Carolina to Santiago flight tickets
Air Canada
Mar 22
CLT7:50 amCharlotte Douglas
26h 25m
1 stop
SCL11:15 amSantiago Arturo Merino Benitez
Mar 24
SCL7:55 pmSantiago Arturo Merino Benitez
21h 22m
1 stop
CLT4:17 pmCharlotte Douglas
$883
Find similar
Air Canada
Nov 10
CLT5:05 pmCharlotte Douglas
17h 10m
1 stop
SCL12:15 pmSantiago Arturo Merino Benitez
Nov 13
SCL8:55 pmSantiago Arturo Merino Benitez
21h 22m
1 stop
CLT4:17 pmCharlotte Douglas
$1,233
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sat 12/6

1:57 pm-10:15 pm

2 stops30h 18m

Santiago Arturo Merino Benitez

Sat 12/13

11:25 pm-12:41 pm

1 stop15h 16m

$629

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sat 12/6

7:00 am-12:15 pm

3 stops27h 15m

Santiago Arturo Merino Benitez

Sat 12/13

12:30 pm-7:10 pm

2 stops32h 40m

$635

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 12/4

12:51 pm-7:40 am

1 stop16h 49m

Santiago Arturo Merino Benitez

Thu 12/11

11:10 pm-3:15 pm

1 stop18h 05m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 12/4

12:51 pm-5:35 am

2 stops14h 44m

Santiago Arturo Merino Benitez

Thu 12/11

7:15 am-11:50 pm

3 stops18h 35m

$669

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Thu 12/4

1:22 pm-6:55 am

1 stop15h 33m

Santiago Arturo Merino Benitez

Tue 12/9

11:30 pm-1:28 pm

1 stop15h 58m

$684

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

5:18 pm-3:30 pm

2 stops20h 12m

Santiago Arturo Merino Benitez

Thu 2/5

11:10 pm-12:07 pm

1 stop14h 57m

$704

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 1/12

6:55 pm-9:00 am

1 stop12h 05m

Santiago Arturo Merino Benitez

Mon 2/2

11:55 pm-6:25 pm

1 stop20h 30m

$714

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 1/12

10:32 am-9:00 am

2 stops20h 28m

Santiago Arturo Merino Benitez

Mon 2/2

10:35 pm-3:14 pm

2 stops18h 39m

$719

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 11/26

6:40 am-8:50 am

2 stops24h 10m

Santiago Arturo Merino Benitez

Mon 12/1

10:45 pm-9:39 pm

2 stops24h 54m

$719

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 11/26

6:45 am-8:50 am

1 stop24h 05m

Santiago Arturo Merino Benitez

Mon 12/1

10:45 pm-10:51 am

1 stop14h 06m

$723

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Santiago from

How to get the cheapest flight ticket from South Carolina to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $722. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $1,089.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from South Carolina to Santiago when you can find flight prices for as low as $782. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $897 per ticket.

Can stopping save me money on South Carolina to Santiago flights?

You could potentially save up to 14% on your flight if you consider stops on a South Carolina to Santiago flight.

Cheap South Carolina to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago

Direct flights

None
There are no direct flights from South Carolina to Santiago. There are no popular flight routes from South Carolina to Santiago.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

    Prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from South Carolina to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago

Compare and see reviews for airlines that fly from South Carolina to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $532Free CancellationRating
7.9
8,001 reviews
Search Delta flights
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,872 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Santiago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Santiago?

momondo helps you find the best flight between South Carolina and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from South Carolina and alert you when they change.

An easier way to manage your Santiago trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 12/6
Sat 12/13
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Chile