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Cheap flights from South Carolina to Santiago from $548

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 am - 8:15 am
CLT
-
SCL
23h 15m2 stops
Multiple Airlines Logo
5:50 am - 10:07 am
SCL
-
CLT
29h 17m2 stops
$548Multiple Airlines
Fri, Mar 6 - Fri, Mar 13
Multiple Airlines Logo
7:00 am - 8:15 am
CLT
-
SCL
23h 15m2 stops
Multiple Airlines Logo
10:35 am - 10:07 am
SCL
-
CLT
24h 32m1 stop
$565Multiple Airlines
Fri, Mar 6 - Fri, Mar 13
Multiple Airlines Logo
7:00 am - 8:15 am
CLT
-
SCL
23h 15m2 stops
Multiple Airlines Logo
12:28 pm - 10:12 am
SCL
-
CLT
22h 44m2 stops
$572Multiple Airlines
Fri, Mar 6 - Sun, Mar 15
Multiple Airlines Logo
7:00 am - 8:15 am
CLT
-
SCL
23h 15m2 stops
Multiple Airlines Logo
10:35 am - 8:11 am
SCL
-
CLT
22h 36m2 stops
$592Multiple Airlines
Fri, Mar 6 - Sat, Mar 14
American Airlines Logo
11:04 am - 6:50 am
CHS
-
SCL
19h 46m1 stop
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
CHS
13h 54m1 stop
$784American Airlines
Wed, May 6 - Fri, May 15
American Airlines Logo
10:57 am - 6:50 am
CHS
-
SCL
19h 53m2 stops
American Airlines Logo
8:30 pm - 12:47 pm
SCL
-
CHS
16h 17m1 stop
$789American Airlines
Wed, May 6 - Fri, May 15
LATAM Airlines Logo
12:20 pm - 4:50 am
CHS
-
SCL
16h 30m2 stops
LATAM Airlines Logo
4:50 pm - 11:15 am
SCL
-
CHS
18h 25m2 stops
$797LATAM Airlines
Wed, Apr 29 - Sun, May 3
Azul Logo
3:23 pm - 7:50 am
SAV
-
SCL
15h 27m1 stop
Azul Logo
9:45 pm - 1:14 pm
SCL
-
SAV
16h 29m1 stop
$805Azul
Mon, Mar 16 - Tue, Mar 24
Avianca Logo
9:50 am - 7:50 am
SAV
-
SCL
21h 00m2 stops
Avianca Logo
9:45 pm - 2:40 pm
SCL
-
SAV
17h 55m2 stops
$809Avianca
Mon, Mar 16 - Mon, Mar 23
LATAM Airlines Logo
6:26 pm - 7:40 am
SAV
-
SCL
12h 14m1 stop
LATAM Airlines Logo
8:50 am - 11:53 pm
SCL
-
SAV
16h 03m2 stops
$818LATAM Airlines
Mon, Mar 16 - Tue, Mar 24

LATAM Airlines flights from South Carolina to Santiago

Our best LATAM Airlines deals on South Carolina to Santiago flight tickets
LATAM Airlines
Mar 17
CLT12:43 pmCharlotte Douglas
17h 57m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 24
SCL10:10 pmSantiago Arturo Merino Benitez
21h 08m
1 stop
CLT6:18 pmCharlotte Douglas
$734
LATAM Airlines
Mar 17
CLT3:25 pmCharlotte Douglas
13h 30m
1 stop
SCL5:55 amSantiago Arturo Merino Benitez
Mar 24
SCL5:15 amSantiago Arturo Merino Benitez
19h 33m
2 stops
CLT11:48 pmCharlotte Douglas
$748
LATAM Airlines
Mar 17
CLT12:43 pmCharlotte Douglas
17h 02m
2 stops
SCL6:45 amSantiago Arturo Merino Benitez
Mar 24
SCL6:30 pmSantiago Arturo Merino Benitez
20h 11m
2 stops
CLT1:41 pmCharlotte Douglas
$761

American Airlines flights from South Carolina to Santiago

Our best American Airlines deals on South Carolina to Santiago flight tickets
American Airlines
May 6
CHS11:04 amCharleston
19h 46m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
May 15
SCL8:30 pmSantiago Arturo Merino Benitez
13h 54m
1 stop
CHS10:24 amCharleston
$784
American Airlines
May 6
CHS10:57 amCharleston
19h 53m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
May 15
SCL8:30 pmSantiago Arturo Merino Benitez
16h 15m
2 stops
CHS12:45 pmCharleston
$789
American Airlines
Apr 1
GSP7:26 pmGreenville
11h 24m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Apr 15
SCL8:30 pmSantiago Arturo Merino Benitez
21h 45m
1 stop
GSP6:15 pmGreenville
$820

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 3/6

7:00 am-8:15 am

2 stops23h 15m

Santiago Arturo Merino Benitez

Fri 3/13

5:50 am-10:07 am

2 stops29h 17m

$548

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 3/6

7:00 am-8:15 am

2 stops23h 15m

Santiago Arturo Merino Benitez

Fri 3/13

10:35 am-10:07 am

1 stop24h 32m

$565

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 3/6

7:00 am-8:15 am

2 stops23h 15m

Santiago Arturo Merino Benitez

Sun 3/15

12:28 pm-10:12 am

2 stops22h 44m

$572

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Fri 3/6

7:00 am-8:15 am

2 stops23h 15m

Santiago Arturo Merino Benitez

Sat 3/14

10:35 am-8:11 am

2 stops22h 36m

$592

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 5/6

11:04 am-6:50 am

1 stop19h 46m

Santiago Arturo Merino Benitez

Fri 5/15

8:30 pm-10:24 am

1 stop13h 54m

$784

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 5/6

10:57 am-6:50 am

2 stops19h 53m

Santiago Arturo Merino Benitez

Fri 5/15

8:30 pm-12:47 pm

1 stop16h 17m

$789

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 4/29

12:20 pm-4:50 am

2 stops16h 30m

Santiago Arturo Merino Benitez

Sun 5/3

4:50 pm-11:15 am

2 stops18h 25m

$797

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Mon 3/16

3:23 pm-7:50 am

1 stop15h 27m

Santiago Arturo Merino Benitez

Tue 3/24

9:45 pm-1:14 pm

1 stop16h 29m

$805

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Mon 3/16

9:50 am-7:50 am

2 stops21h 00m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-2:40 pm

2 stops17h 55m

$809

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Mon 3/16

6:26 pm-7:40 am

1 stop12h 14m

Santiago Arturo Merino Benitez

Tue 3/24

8:50 am-11:53 pm

2 stops16h 03m

$818

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from South Carolina to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Santiago flights?

You could potentially save up to 13% on your flight if you consider stops on a South Carolina to Santiago flight.

Cheap South Carolina to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago

Fastest flight time

12h 32m

Direct flights

None
The fastest flight from South Carolina to Santiago takes 12h 32m
There are no direct flights from South Carolina to Santiago. There are no popular flight routes from South Carolina to Santiago.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

    Prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from South Carolina to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago

Compare and see reviews for airlines that fly from South Carolina to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,901 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $703Free CancellationRating
7.2
11,099 reviews
Search American Airlines flights
DeltaPriceFrom $793Free CancellationRating
7.9
8,035 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Santiago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Santiago?

momondo helps you find the best flight between South Carolina and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from South Carolina and alert you when they change.

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