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Cheap flights from South Carolina to Santiago from $334

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Santiago departing on 11/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Santiago

Cheap round-trip flights

Logo
3:10 pm - 4:15 amCLT-SCL
37h 05m2 stops
Logo
11:00 am - 12:45 pmSCL-CLT
26h 45m1 stop
$544
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Wed, Sep 3 - Wed, Sep 10
Logo
1:50 pm - 10:15 pmCLT-SCL
31h 25m2 stops
Logo
5:55 am - 12:45 pmSCL-CLT
31h 50m2 stops
$611
Find Deal
Mon, Sep 15 - Sat, Sep 20
LATAM Airlines Logo
10:00 am - 6:55 amCLT-SCL
18h 55m1 stop
LATAM Airlines Logo
8:50 pm - 1:52 pmSCL-CLT
19h 02m2 stops
$677LATAM Airlines
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Wed, Nov 26 - Mon, Dec 1
LATAM Airlines Logo
10:05 am - 7:45 amCLT-SCL
20h 40m1 stop
LATAM Airlines Logo
5:55 pm - 1:23 pmSCL-CLT
20h 28m2 stops
$681LATAM Airlines
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Wed, Oct 1 - Tue, Oct 14
American Airlines Logo
9:45 am - 8:00 amSAV-SCL
21h 15m1 stop
American Airlines Logo
9:15 pm - 9:09 amSCL-SAV
12h 54m1 stop
$734American Airlines
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Wed, Oct 22 - Wed, Oct 29
American Airlines Logo
4:46 pm - 8:00 amGSP-SCL
14h 14m1 stop
American Airlines Logo
10:15 pm - 11:43 amSCL-GSP
14h 28m1 stop
$734American Airlines
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Wed, Oct 15 - Mon, Oct 27
United Airlines Logo
7:45 pm - 8:50 amCHS-SCL
59h 05m2 stops
United Airlines Logo
10:45 pm - 4:16 pmSCL-CHS
19h 31m1 stop
$744United Airlines
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Sat, Nov 8 - Fri, Nov 14
Delta Logo
6:24 pm - 7:00 amCLT-SCL
34h 36m1 stop
Delta Logo
6:30 pm - 1:37 pmSCL-CLT
21h 07m2 stops
$760Delta
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Tue, Dec 23 - Tue, Dec 30
Delta Logo
11:45 am - 6:55 amCHS-SCL
17h 10m1 stop
Delta Logo
12:55 am - 6:55 pmSCL-CHS
20h 00m2 stops
$764Delta
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Sat, Nov 8 - Thu, Nov 13
United Airlines Logo
5:28 pm - 8:50 amCLT-SCL
37h 22m2 stops
United Airlines Logo
10:45 pm - 9:40 pmSCL-CLT
24h 55m2 stops
$765United Airlines
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Sun, Dec 7 - Thu, Dec 18

American Airlines flights from South Carolina to Santiago

Our best American Airlines deals on South Carolina to Santiago flight tickets
American Airlines
Oct 22
SAV9:45 amSavannah/Hilton Head
21h 15m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Oct 29
SCL9:15 pmSantiago Arturo Merino Benitez
12h 54m
1 stop
SAV9:09 amSavannah/Hilton Head
$734
Find similar
American Airlines
Oct 22
SAV10:24 amSavannah/Hilton Head
20h 36m
2 stops
SCL8:00 amSantiago Arturo Merino Benitez
Oct 29
SCL9:15 pmSantiago Arturo Merino Benitez
12h 54m
1 stop
SAV9:09 amSavannah/Hilton Head
$738
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American Airlines
Oct 1
GSP6:00 amGreenville
24h 55m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Oct 14
SCL9:55 pmSantiago Arturo Merino Benitez
19h 03m
1 stop
GSP3:58 pmGreenville
$742
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Delta flights from South Carolina to Santiago

Our best Delta deals on South Carolina to Santiago flight tickets
Delta
Dec 23
CLT6:24 pmCharlotte Douglas
34h 36m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Dec 30
SCL6:30 pmSantiago Arturo Merino Benitez
21h 07m
2 stops
CLT1:37 pmCharlotte Douglas
$760
Find similar
Delta
Nov 8
CHS11:45 amCharleston
17h 10m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Nov 13
SCL12:55 amSantiago Arturo Merino Benitez
20h 00m
2 stops
CHS6:55 pmCharleston
$764
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Delta
Sep 25
SAV5:03 pmSavannah/Hilton Head
12h 57m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Sep 28
SCL1:40 amSantiago Arturo Merino Benitez
21h 05m
2 stops
SAV9:45 pmSavannah/Hilton Head
$774
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momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 9/3

3:10 pm-4:15 am

2 stops37h 05m

Santiago Arturo Merino Benitez

Wed 9/10

11:00 am-12:45 pm

1 stop26h 45m

$544

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Mon 9/15

1:50 pm-10:15 pm

2 stops31h 25m

Santiago Arturo Merino Benitez

Sat 9/20

5:55 am-12:45 pm

2 stops31h 50m

$611

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 11/26

10:00 am-6:55 am

1 stop18h 55m

Santiago Arturo Merino Benitez

Mon 12/1

8:50 pm-1:52 pm

2 stops19h 02m

$677

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 10/1

10:05 am-7:45 am

1 stop20h 40m

Santiago Arturo Merino Benitez

Tue 10/14

5:55 pm-1:23 pm

2 stops20h 28m

$681

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Wed 10/22

9:45 am-8:00 am

1 stop21h 15m

Santiago Arturo Merino Benitez

Wed 10/29

9:15 pm-9:09 am

1 stop12h 54m

$734

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

4:46 pm-8:00 am

1 stop14h 14m

Santiago Arturo Merino Benitez

Mon 10/27

10:15 pm-11:43 am

1 stop14h 28m

$734

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 11/8

7:45 pm-8:50 am

2 stops59h 05m

Santiago Arturo Merino Benitez

Fri 11/14

10:45 pm-4:16 pm

1 stop19h 31m

$744

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Tue 12/23

6:24 pm-7:00 am

1 stop34h 36m

Santiago Arturo Merino Benitez

Tue 12/30

6:30 pm-1:37 pm

2 stops21h 07m

$760

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 11/8

11:45 am-6:55 am

1 stop17h 10m

Santiago Arturo Merino Benitez

Thu 11/13

12:55 am-6:55 pm

2 stops20h 00m

$764

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sun 12/7

5:28 pm-8:50 am

2 stops37h 22m

Santiago Arturo Merino Benitez

Thu 12/18

10:45 pm-9:40 pm

2 stops24h 55m

$765

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from South Carolina to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from South Carolina to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $567. If you don’t want to visit Santiago in September, then you should wait until October to fly from South Carolina, when ticket prices are also cheap, with an average price of $673.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $722. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $1,089.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from South Carolina to Santiago when you can find flight prices for as low as $782. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $897 per ticket.

Can stopping save me money on South Carolina to Santiago flights?

You could potentially save up to 35% on your flight if you consider stops on a South Carolina to Santiago flight.

Cheap South Carolina to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Santiago

Best Price Found

$334

Fastest flight time

11h 10m

Direct flights

None

Airports in Santiago

1 airport
The best one-way flight to Santiago from South Carolina in the past 72 hours is $334. The best round-trip flight deal from South Carolina to Santiago found on momondo in the last 72 hours is $544.
The fastest flight from South Carolina to Santiago takes 11h 10m
There are no direct flights from South Carolina to Santiago. Popular non-direct routes for this connection are Charlotte Douglas Airport - Santiago Arturo Merino Benitez Airport, Charleston Airport - Santiago Arturo Merino Benitez Airport and Savannah/Hilton Head Airport - Santiago Arturo Merino Benitez Airport.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • When did momondo last update prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

    Prices for flights from South Carolina to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from South Carolina to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Santiago

Compare and see reviews for airlines that fly from South Carolina to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $532Free CancellationRating
8.0
7,985 reviews
Search Delta flights
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,833 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $702Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Santiago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Santiago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Santiago?

momondo helps you find the best flight between South Carolina and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from South Carolina and alert you when they change.

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