What is the cheapest airline that flies from South Carolina to Panama?

United Airlines, American Airlines, and Delta are the most popular carriers operating from South Carolina to Panama

What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Columbia and flying into Panama City (one of the most popular routes), then the duration is 7h 11m on average. Another popular route from South Carolina to Panama is flying from Charleston to Panama City, which will take roughly 7h 16m. Keep in mind that layovers or delays could extend your travel time.

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of August 2025, there are 3 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$163 Cheap Flights from South Carolina to Panama in 2025

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Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

9:37 am - 3:35 pmCHS-PTY

5h 58m1 stop

4:40 pm - 11:29 pmPTY-CHS

6h 49m1 stop

$369American Airlines

Find Deal

Fri, Feb 6 - Thu, Feb 12

7:30 am - 1:10 pmCHS-PTY

5h 40m1 stop

4:40 pm - 10:05 amPTY-CHS

17h 25m2 stops

$374American Airlines

Find Deal

Fri, Feb 6 - Thu, Feb 12

6:15 am - 9:10 pmCLT-PTY

15h 55m2 stops

3:25 am - 9:59 pmPTY-CLT

17h 34m2 stops

$386

Find Deal

Wed, Oct 8 - Fri, Oct 10

6:45 am - 2:02 pmGSP-PTY

7h 17m1 stop

3:27 pm - 11:36 pmPTY-GSP

8h 09m1 stop

$391Delta

Find Deal

Wed, Jan 21 - Wed, Feb 4

7:43 pm - 2:03 pmCHS-PTY

19h 20m2 stops

3:15 pm - 1:45 pmPTY-CHS

21h 30m2 stops

$394American Airlines

Find Deal

Mon, Oct 20 - Mon, Oct 27

5:45 am - 9:10 pmCLT-PTY

16h 25m2 stops

5:25 pm - 12:45 pmPTY-CLT

18h 20m2 stops

$396

Find Deal

Wed, Sep 17 - Wed, Sep 24

6:04 pm - 1:10 pmGSP-PTY

19h 06m2 stops

4:40 pm - 12:15 amPTY-GSP

7h 35m1 stop

$396American Airlines

Find Deal

Wed, Jan 21 - Wed, Feb 4

5:30 am - 12:50 pmGSP-PTY

8h 20m1 stop

2:10 pm - 11:34 pmPTY-GSP

8h 24m1 stop

$397Delta

Find Deal

Mon, Sep 8 - Tue, Sep 16

7:00 am - 6:37 pmGSP-PTY

12h 37m1 stop

3:30 pm - 3:46 pmPTY-GSP

23h 16m1 stop

$400United Airlines

Find Deal

Tue, Sep 16 - Tue, Sep 23

7:00 am - 6:37 pmGSP-PTY

12h 37m1 stop

3:30 pm - 3:46 pmPTY-GSP

23h 16m1 stop

$406United Airlines

Find Deal

Mon, Sep 8 - Mon, Sep 15

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Jan 21

GSP6:45 amGreenville

7h 17m

1 stop

PTY2:02 pmPanama City Tocumen Intl

Feb 4

PTY3:27 pmPanama City Tocumen Intl

8h 09m

1 stop

GSP11:36 pmGreenville

$391

Find similar

Delta

Sep 8

GSP5:30 amGreenville

8h 20m

1 stop

PTY12:50 pmPanama City Tocumen Intl

Sep 16

PTY2:10 pmPanama City Tocumen Intl

8h 24m

1 stop

GSP11:34 pmGreenville

$397

Find similar

Delta

Sep 10

GSP2:15 pmGreenville

23h 40m

1 stop

PTY12:55 pmPanama City Tocumen Intl

Sep 17

PTY2:10 pmPanama City Tocumen Intl

8h 24m

1 stop

GSP11:34 pmGreenville

$403

Find similar

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets

American Airlines

Feb 6

CHS9:37 amCharleston

5h 58m

1 stop

PTY3:35 pmPanama City Tocumen Intl

Feb 12

PTY4:40 pmPanama City Tocumen Intl

6h 49m

1 stop

CHS11:29 pmCharleston

$369

Find similar

American Airlines

Feb 6

CHS7:30 amCharleston

5h 40m

1 stop

PTY1:10 pmPanama City Tocumen Intl

Feb 12

PTY4:40 pmPanama City Tocumen Intl

17h 25m

2 stops

CHS10:05 amCharleston

$374

Find similar

American Airlines

Oct 20

CHS7:43 pmCharleston

19h 20m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 27

PTY3:15 pmPanama City Tocumen Intl

21h 30m

2 stops

CHS1:45 pmCharleston

$394

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 2/6

9:37 am-3:35 pm

1 stop5h 58m

Panama City Tocumen Intl

Thu 2/12

4:40 pm-11:29 pm

1 stop6h 49m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 2/6

7:30 am-1:10 pm

1 stop5h 40m

Panama City Tocumen Intl

Thu 2/12

4:40 pm-10:05 am

2 stops17h 25m

$374

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 10/8

6:15 am-9:10 pm

2 stops15h 55m

Panama City Tocumen Intl

Fri 10/10

3:25 am-9:59 pm

2 stops17h 34m

$386

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:45 am-2:02 pm

1 stop7h 17m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 10/20

7:43 pm-2:03 pm

2 stops19h 20m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-1:45 pm

2 stops21h 30m

$394

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 9/17

5:45 am-9:10 pm

2 stops16h 25m

Panama City Tocumen Intl

Wed 9/24

5:25 pm-12:45 pm

2 stops18h 20m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:04 pm-1:10 pm

2 stops19h 06m

Panama City Tocumen Intl

Wed 2/4

4:40 pm-12:15 am

1 stop7h 35m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 9/8

5:30 am-12:50 pm

1 stop8h 20m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-11:34 pm

1 stop8h 24m

$397

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/16

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Tue 9/23

3:30 pm-3:46 pm

1 stop23h 16m

$400

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 9/8

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 9/15

3:30 pm-3:46 pm

1 stop23h 16m

$406

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How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of November is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $402. If you don’t want to visit Panama in November, then you should wait until September to fly from South Carolina, when ticket prices are also cheap, with an average price of $444.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from South Carolina. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from South Carolina to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 3% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Direct flights	None

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of August 2025, there are 3 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $349	Free Cancellation	Rating 7.9 7,982 reviews	Search Delta flights
United Airlines	PriceFrom $352	Free Cancellation	Rating 7.4 8,928 reviews	Search United Airlines flights
American Airlines	PriceFrom $361	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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Popular cities in Panama

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Cheap flights from South Carolina to Panama from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

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Filter for what you want

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Find the cheapest flights from South Carolina to Panama

Cheap round-trip flights

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Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets

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How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 3% on your flight if you consider stops on a South Carolina to Panama flight.

What is the cheapest airline that flies from South Carolina to Panama?

United Airlines, American Airlines, and Delta are the most popular carriers operating from South Carolina to Panama

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Direct flights

When did momondo last update prices for flights from South Carolina to Panama?

How many operators does momondo search for flights from South Carolina to Panama?

How old do you have to be to fly from South Carolina to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

How can momondo help me find flights from South Carolina to Panama?

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo