What is the cheapest airline that flies from South Carolina to Panama?

United Airlines, Copa Airlines, and Delta are the most popular carriers operating from South Carolina to Panama

How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Myrtle Beach and flying into Panama City (one of the most popular routes), then the duration is 8h 05m on average. Another popular route from South Carolina to Panama is flying from Charleston to Panama City, which will take roughly 8h 30m. Keep in mind that layovers or delays could extend your travel time.

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of June 2026, there are 4 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$232 Cheap Flights from South Carolina to Panama in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:58 pm - 8:37 pm

CLT

PTY

7h 39m

1 stop

5:30 am - 4:05 pm

PTY

CLT

9h 35m

2 stops

$518Multiple Airlines

Sun, Sep 6 - Thu, Sep 10

1:58 pm - 8:37 pm

CLT

PTY

7h 39m

1 stop

3:10 pm - 4:05 pm

PTY

CLT

23h 55m

2 stops

$525Multiple Airlines

Mon, Sep 7 - Wed, Sep 9

6:00 am - 1:31 pm

CLT

PTY

7h 31m

1 stop

6:46 pm - 10:04 am

PTY

CLT

15h 18m

1 stop

$533Copa Airlines

Thu, Nov 5 - Wed, Nov 11

7:00 am - 7:31 pm

CHS

PTY

13h 31m

1 stop

9:45 am - 11:59 pm

PTY

CHS

13h 14m

1 stop

$537United Airlines

Wed, Sep 16 - Tue, Sep 22

11:00 am - 7:31 pm

CLT

PTY

9h 31m

1 stop

3:30 pm - 10:54 am

PTY

CLT

18h 24m

1 stop

$539United Airlines

Mon, Sep 28 - Thu, Oct 1

5:30 pm - 12:55 pm

CLT

PTY

20h 25m

1 stop

2:23 pm - 11:59 pm

PTY

CLT

8h 36m

1 stop

$546Delta

Sun, Sep 6 - Thu, Sep 10

7:55 pm - 6:13 am

CLT

PTY

11h 18m

1 stop

6:41 pm - 9:44 am

PTY

CLT

14h 03m

1 stop

$549Copa Airlines

Fri, Aug 14 - Sat, Aug 29

5:46 am - 12:55 pm

GSP

PTY

8h 09m

1 stop

2:20 pm - 10:59 pm

PTY

GSP

7h 39m

1 stop

$575Delta

Tue, Aug 11 - Wed, Aug 19

7:00 am - 12:24 pm

GSP

PTY

6h 24m

1 stop

3:35 pm - 11:14 pm

PTY

GSP

6h 39m

1 stop

$583American Airlines

Tue, Sep 15 - Thu, Oct 15

4:15 pm - 12:14 pm

CHS

PTY

20h 59m

2 stops

1:14 pm - 10:16 am

PTY

CHS

20h 02m

2 stops

$588American Airlines

Wed, Jul 15 - Fri, Jul 24

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Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Sep 6

CLT5:30 pmCharlotte Douglas

20h 25m

1 stop

PTY12:55 pmPanama City Tocumen Intl

Sep 10

PTY2:23 pmPanama City Tocumen Intl

8h 36m

1 stop

CLT11:59 pmCharlotte Douglas

$546

Delta

Sep 5

CLT7:40 amCharlotte Douglas

6h 25m

1 stop

PTY1:05 pmPanama City Tocumen Intl

Sep 9

PTY2:23 pmPanama City Tocumen Intl

8h 36m

1 stop

CLT11:59 pmCharlotte Douglas

$569

Delta

Aug 11

GSP5:46 amGreenville

8h 09m

1 stop

PTY12:55 pmPanama City Tocumen Intl

Aug 19

PTY2:20 pmPanama City Tocumen Intl

7h 39m

1 stop

GSP10:59 pmGreenville

$575

Copa Airlines flights from South Carolina to Panama

Our best Copa Airlines deals on South Carolina to Panama flight tickets

Copa Airlines

Nov 5

CLT6:00 amCharlotte Douglas

7h 31m

1 stop

PTY1:31 pmPanama City Tocumen Intl

Nov 11

PTY6:46 pmPanama City Tocumen Intl

15h 18m

1 stop

CLT10:04 amCharlotte Douglas

$533

Copa Airlines

Aug 14

CLT7:55 pmCharlotte Douglas

11h 18m

1 stop

PTY6:13 amPanama City Tocumen Intl

Aug 29

PTY6:41 pmPanama City Tocumen Intl

14h 03m

1 stop

CLT9:44 amCharlotte Douglas

$549

Copa Airlines

Nov 26

CLT7:55 pmCharlotte Douglas

24h 40m

1 stop

PTY8:35 pmPanama City Tocumen Intl

Nov 30

PTY10:29 pmPanama City Tocumen Intl

11h 15m

1 stop

CLT9:44 amCharlotte Douglas

$552

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 9/6

1:58 pm-8:37 pm

1 stop7h 39m

Panama City Tocumen Intl

Thu 9/10

5:30 am-4:05 pm

2 stops9h 35m

$518

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 9/7

1:58 pm-8:37 pm

1 stop7h 39m

Panama City Tocumen Intl

Wed 9/9

3:10 pm-4:05 pm

2 stops23h 55m

$525

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/5

6:00 am-1:31 pm

1 stop7h 31m

Panama City Tocumen Intl

Wed 11/11

6:46 pm-10:04 am

1 stop15h 18m

$533

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 9/16

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Tue 9/22

9:45 am-11:59 pm

1 stop13h 14m

$537

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 9/28

11:00 am-7:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Thu 10/1

3:30 pm-10:54 am

1 stop18h 24m

$539

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 9/6

5:30 pm-12:55 pm

1 stop20h 25m

Panama City Tocumen Intl

Thu 9/10

2:23 pm-11:59 pm

1 stop8h 36m

$546

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 8/14

7:55 pm-6:13 am

1 stop11h 18m

Panama City Tocumen Intl

Sat 8/29

6:41 pm-9:44 am

1 stop14h 03m

$549

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/11

5:46 am-12:55 pm

1 stop8h 09m

Panama City Tocumen Intl

Wed 8/19

2:20 pm-10:59 pm

1 stop7h 39m

$575

Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

7:00 am-12:24 pm

1 stop6h 24m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$583

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 7/15

4:15 pm-12:14 pm

2 stops20h 59m

Panama City Tocumen Intl

Fri 7/24

1:14 pm-10:16 am

2 stops20h 02m

$588

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $235. If you don’t want to visit Panama in September, then you should wait until October to fly from South Carolina, when ticket prices are also cheap, with an average price of $309.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time	7h 31m
Direct flights	None

The fastest flight from South Carolina to Panama takes 7h 31m

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

Frequently asked questions about flying from South Carolina to Panama

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of June 2026, there are 4 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $235	Free Cancellation	Rating 7.4 9,894 reviews	Search United Airlines flights
Delta	PriceFrom $369	Free Cancellation	Rating 7.8 8,449 reviews	Search Delta flights
American Airlines	PriceFrom $399	Free Cancellation	Rating 7.1 11,770 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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Flights to Panama Cityfrom $373

Flights to Bocas del Torofrom $1,167

Flights to Davidfrom $422

Flights to Changuinola

Cheap flights from South Carolina to Panama from $232

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 12/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Copa Airlines flights from South Carolina to Panama

Our best Copa Airlines deals on South Carolina to Panama flight tickets

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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

What is the cheapest month to fly to Panama?

Can stopping save me money on South Carolina to Panama flights?

What is the cheapest airline that flies from South Carolina to Panama?

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time

Direct flights

Frequently asked questions about flying from South Carolina to Panama

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

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According to popular flight searches on momondo this year