How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Greenville and flying into Panama City (one of the most popular routes), then the duration is 5h 54m on average. Another popular route from South Carolina to Panama is flying from Charleston to Panama City, which will take roughly 8h 02m. Keep in mind that layovers or delays could extend your travel time.

What is the cheapest airline that flies from South Carolina to Panama?

American Airlines, United Airlines, and Delta are the most popular carriers operating from South Carolina to Panama

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of September 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$277 Cheap Flights from South Carolina to Panama in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:21 am - 2:34 pmCHS Charleston-PTY Panama City Tocumen Intl

7h 13m1 stop Miami

3:13 pm - 10:13 pmPTY Panama City Tocumen Intl-CHS Charleston

7h 00m1 stop Miami

$627American Airlines

Fri, Nov 27 - Wed, Dec 2

7:00 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

13h 02m1 stop Newark

8:55 am - 9:59 pmPTY Panama City Tocumen Intl-CHS Charleston

13h 04m1 stop Houston George Bush Intcntl

$627United Airlines

Tue, Dec 1 - Wed, Dec 9

10:23 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

9h 39m1 stop Newark

10:00 am - 11:59 pmPTY Panama City Tocumen Intl-CHS Charleston

13h 59m1 stop Newark

$627United Airlines

Tue, Dec 1 - Tue, Dec 8

7:00 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

13h 02m1 stop Newark

8:55 am - 9:59 pmPTY Panama City Tocumen Intl-CHS Charleston

13h 04m1 stop Houston George Bush Intcntl

$627United Airlines

Wed, Dec 2 - Mon, Dec 7

8:19 pm - 1:26 pmCHS Charleston-PTY Panama City Tocumen Intl

17h 07m1 stop Miami

4:04 pm - 12:37 pmPTY Panama City Tocumen Intl-CHS Charleston

20h 33m2 stops Miami Charlotte Douglas

$628American Airlines

Mon, Jan 18 - Tue, Feb 16

7:21 pm - 1:26 pmCHS Charleston-PTY Panama City Tocumen Intl

18h 05m2 stops Charlotte Douglas Miami

4:04 pm - 12:23 pmPTY Panama City Tocumen Intl-CHS Charleston

20h 19m2 stops Miami Dallas/Fort Worth

$628American Airlines

Mon, Jan 18 - Tue, Feb 16

7:00 am - 12:59 pmGSP Greenville-PTY Panama City Tocumen Intl

6h 59m1 stop Atlanta Hartsfield-Jackson

3:24 pm - 10:51 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 27m1 stop Atlanta Hartsfield-Jackson

$673Delta

Thu, Oct 29 - Thu, Nov 5

5:40 am - 12:59 pmGSP Greenville-PTY Panama City Tocumen Intl

8h 19m1 stop Atlanta Hartsfield-Jackson

2:24 pm - 10:51 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 27m1 stop Atlanta Hartsfield-Jackson

$673Delta

Mon, Oct 26 - Wed, Oct 28

10:23 am - 8:02 pmCHS Charleston-PTY Panama City Tocumen Intl

9h 39m1 stop Newark

10:00 am - 11:59 pmPTY Panama City Tocumen Intl-CHS Charleston

13h 59m1 stop Newark

$676Copa Airlines

Wed, Dec 2 - Mon, Dec 7

6:00 am - 7:38 pmCHS Charleston-PTY Panama City Tocumen Intl

13h 38m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:00 am - 11:19 pmPTY Panama City Tocumen Intl-CHS Charleston

13h 19m1 stop Newark

$681Copa Airlines

Thu, Dec 10 - Mon, Feb 1

Cheap last minute flights

Enter your travel dates to find the best prices.

5:45 am - 12:58 pmGSP Greenville-PTY Panama City Tocumen Intl

8h 13m1 stop Atlanta Hartsfield-Jackson

2:24 pm - 10:51 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 27m1 stop Atlanta Hartsfield-Jackson

$775Delta

Wed, Sep 30 - Wed, Oct 7

11:30 am - 7:31 pmGSP Greenville-PTY Panama City Tocumen Intl

9h 01m1 stop Newark

9:45 am - 11:13 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 28m1 stop Newark

$775United Airlines

Wed, Sep 30 - Tue, Oct 6

7:00 am - 6:37 pmGSP Greenville-PTY Panama City Tocumen Intl

12h 37m1 stop Houston George Bush Intcntl

9:45 am - 11:13 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 28m1 stop Newark

$775United Airlines

Thu, Oct 1 - Wed, Oct 7

7:00 am - 6:37 pmGSP Greenville-PTY Panama City Tocumen Intl

12h 37m1 stop Houston George Bush Intcntl

9:45 am - 11:13 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 28m1 stop Newark

$775United Airlines

Thu, Oct 1 - Tue, Oct 6

5:46 pm - 2:14 pmGSP Greenville-PTY Panama City Tocumen Intl

21h 28m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

9:45 am - 11:13 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 28m1 stop Newark

$779United Airlines

Wed, Sep 30 - Tue, Oct 6

6:00 am - 12:16 pmGSP Greenville-PTY Panama City Tocumen Intl

7h 16m1 stop Miami

2:02 pm - 1:05 pmPTY Panama City Tocumen Intl-GSP Greenville

22h 03m2 stops Miami Charlotte Douglas

$836American Airlines

Fri, Oct 2 - Mon, Oct 5

6:00 am - 12:16 pmGSP Greenville-PTY Panama City Tocumen Intl

7h 16m1 stop Miami

2:02 pm - 10:52 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 50m1 stop Miami

$895American Airlines

Fri, Oct 2 - Thu, Oct 8

8:30 pm - 1:02 pmMYR Myrtle Beach Intl-PTY Panama City Tocumen Intl

17h 32m2 stops Charlotte Douglas Miami

2:02 pm - 11:01 amPTY Panama City Tocumen Intl-MYR Myrtle Beach Intl

19h 59m2 stops Miami Charlotte Douglas

$1,066American Airlines

Sun, Oct 4 - Tue, Oct 6

11:59 am - 8:19 pmMYR Myrtle Beach Intl-PTY Panama City Tocumen Intl

9h 20m1 stop Fort Lauderdale

12:03 pm - 9:13 amPTY Panama City Tocumen Intl-MYR Myrtle Beach Intl

20h 10m1 stop Fort Lauderdale

$1,156Multiple Airlines

Sun, Oct 4 - Tue, Oct 6

11:59 am - 8:19 pmMYR Myrtle Beach Intl-PTY Panama City Tocumen Intl

9h 20m1 stop Fort Lauderdale

9:24 pm - 12:14 pmPTY Panama City Tocumen Intl-MYR Myrtle Beach Intl

37h 50m2 stops San José Juan Santamaria Intl Tampa

$1,243Multiple Airlines

Sun, Oct 4 - Tue, Oct 6

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American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets

American Airlines

Nov 27

CHS7:21 amCharleston

7h 13m

1 stop

PTY2:34 pmPanama City Tocumen Intl

Dec 2

PTY3:13 pmPanama City Tocumen Intl

7h 00m

1 stop

CHS10:13 pmCharleston

$627

American Airlines

Jan 18

CHS7:21 pmCharleston

18h 05m

2 stops

PTY1:26 pmPanama City Tocumen Intl

Feb 16

PTY4:04 pmPanama City Tocumen Intl

20h 19m

2 stops

CHS12:23 pmCharleston

$628

American Airlines

Jan 18

CHS8:19 pmCharleston

17h 07m

1 stop

PTY1:26 pmPanama City Tocumen Intl

Feb 16

PTY2:39 pmPanama City Tocumen Intl

28h 46m

1 stop

CHS7:25 pmCharleston

$634

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Oct 26

GSP5:40 amGreenville

8h 19m

1 stop

PTY12:59 pmPanama City Tocumen Intl

Nov 2

PTY3:24 pmPanama City Tocumen Intl

7h 27m

1 stop

GSP10:51 pmGreenville

$673

Delta

Oct 25

GSP7:14 pmGreenville

18h 45m

1 stop

PTY12:59 pmPanama City Tocumen Intl

Nov 2

PTY3:24 pmPanama City Tocumen Intl

7h 27m

1 stop

GSP10:51 pmGreenville

$680

Delta

Oct 25

GSP10:08 amGreenville

27h 51m

1 stop

PTY12:59 pmPanama City Tocumen Intl

Nov 2

PTY3:24 pmPanama City Tocumen Intl

7h 27m

1 stop

GSP10:51 pmGreenville

$715

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Fri 11/27

7:21 am-2:34 pm

1 stop7h 13m

Panama City Tocumen Intl

Wed 12/2

3:13 pm-10:13 pm

1 stop7h 00m

$627

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Tue 12/1

7:00 am-8:02 pm

1 stop13h 02m

Panama City Tocumen Intl

Wed 12/9

8:55 am-9:59 pm

1 stop13h 04m

$627

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Tue 12/1

10:23 am-8:02 pm

1 stop9h 39m

Panama City Tocumen Intl

Tue 12/8

10:00 am-11:59 pm

1 stop13h 59m

$627

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Wed 12/2

7:00 am-8:02 pm

1 stop13h 02m

Panama City Tocumen Intl

Mon 12/7

8:55 am-9:59 pm

1 stop13h 04m

$627

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/18

8:19 pm-1:26 pm

1 stop17h 07m

Panama City Tocumen Intl

Tue 2/16

4:04 pm-12:37 pm

2 stops20h 33m

$628

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 1/18

7:21 pm-1:26 pm

2 stops18h 05m

Panama City Tocumen Intl

Tue 2/16

4:04 pm-12:23 pm

2 stops20h 19m

$628

GreenvillePanama City

GSP Greenville - PTY Panama City Tocumen Intl

GSPPTY

Greenville

Thu 10/29

7:00 am-12:59 pm

1 stop6h 59m

Panama City Tocumen Intl

Thu 11/5

3:24 pm-10:51 pm

1 stop7h 27m

$673

GreenvillePanama City

GSP Greenville - PTY Panama City Tocumen Intl

GSPPTY

Greenville

Mon 10/26

5:40 am-12:59 pm

1 stop8h 19m

Panama City Tocumen Intl

Wed 10/28

2:24 pm-10:51 pm

1 stop7h 27m

$673

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Wed 12/2

10:23 am-8:02 pm

1 stop9h 39m

Panama City Tocumen Intl

Mon 12/7

10:00 am-11:59 pm

1 stop13h 59m

$676

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Thu 12/10

6:00 am-7:38 pm

2 stops13h 38m

Panama City Tocumen Intl

Mon 2/1

10:00 am-11:19 pm

1 stop13h 19m

$681

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $487. If you don’t want to visit Panama in March, then you should wait until February to fly from South Carolina, when ticket prices are also cheap, with an average price of $570.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 1% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Best Price Found	$277
Fastest flight time	5h 54m
Direct flights	None

The best one-way flight to Panama from South Carolina in the past 72 hours is $277. The best round-trip flight deal from South Carolina to Panama found on momondo in the last 72 hours is $627.

The fastest flight from South Carolina to Panama takes 5h 54m

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

Frequently asked questions about flying from South Carolina to Panama

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of September 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $299	Free Cancellation	Rating 7.8 8,608 reviews	Search Delta flights
United Airlines	PriceFrom $369	Free Cancellation	Rating 7.4 10,261 reviews	Search United Airlines flights
American Airlines	PriceFrom $399	Free Cancellation	Rating 7.0 12,097 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Flights to Panama Cityfrom $408

Flights to Bocas del Torofrom $1,035

Flights to Davidfrom $508

Flights to Changuinola

Cheap flights from South Carolina to Panama from $277

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

What is the cheapest month to fly to Panama?

Can stopping save me money on South Carolina to Panama flights?

What is the cheapest airline that flies from South Carolina to Panama?

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from South Carolina to Panama

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

Explore popular destinations other users love

According to popular flight searches on momondo this year