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Cheap flights from South Carolina to Panama from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 12/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:40 am - 2:14 pm
CHS
-
PTY
8h 34m1 stop
United Airlines Logo
10:55 pm - 8:53 am
PTY
-
CHS
8h 58m1 stop
$370United Airlines
mar., mar. 31 - lun., abr. 13
United Airlines Logo
11:00 am - 8:02 pm
CHS
-
PTY
9h 02m1 stop
United Airlines Logo
11:35 am - 4:17 pm
PTY
-
CHS
28h 42m1 stop
$378United Airlines
lun., ene. 26 - jue., ene. 29
American Airlines Logo
7:02 pm - 2:22 pm
CHS
-
PTY
20h 20m2 stops
American Airlines Logo
1:44 pm - 10:50 am
PTY
-
CHS
20h 06m2 stops
$394American Airlines
sáb., mar. 14 - mar., mar. 17
American Airlines Logo
7:00 pm - 3:38 pm
GSP
-
PTY
20h 38m2 stops
American Airlines Logo
2:27 pm - 12:07 pm
PTY
-
GSP
21h 40m2 stops
$396American Airlines
mié., ene. 21 - mié., feb. 4
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
18h 00m2 stops
Multiple Airlines Logo
5:50 pm - 12:22 pm
PTY
-
CLT
18h 32m2 stops
$428Multiple Airlines
jue., feb. 19 - dom., feb. 22
Delta Logo
7:00 am - 12:55 pm
CAE
-
PTY
6h 55m1 stop
Delta Logo
2:20 pm - 11:55 pm
PTY
-
CAE
8h 35m1 stop
$456Delta
sáb., may. 2 - jue., may. 21
Multiple Airlines Logo
7:00 am - 12:40 am
CLT
-
PTY
17h 40m2 stops
Multiple Airlines Logo
2:55 pm - 12:22 pm
PTY
-
CLT
21h 27m2 stops
$459Multiple Airlines
mié., feb. 25 - dom., mar. 1
Delta Logo
5:30 am - 12:55 pm
CAE
-
PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:55 pm
PTY
-
CAE
8h 35m1 stop
$578Delta
mar., abr. 7 - jue., abr. 16
WestJet Logo
7:33 pm - 9:20 am
AGS
-
PTY
37h 47m2 stops
WestJet Logo
10:20 am - 6:52 pm
PTY
-
AGS
32h 32m2 stops
$1,714WestJet
dom., feb. 1 - jue., feb. 5
WestJet Logo
7:33 pm - 9:20 am
AGS
-
PTY
37h 47m2 stops
WestJet Logo
10:20 am - 6:52 pm
PTY
-
AGS
32h 32m2 stops
$1,722WestJet
dom., feb. 1 - jue., feb. 5

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets
American Airlines
Mar 14
CHS7:02 pmCharleston
20h 20m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Mar 17
PTY1:44 pmPanama City Tocumen Intl
20h 06m
2 stops
CHS10:50 amCharleston
$394
Find similar
American Airlines
Jan 21
GSP7:00 pmGreenville
20h 38m
2 stops
PTY3:38 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
21h 40m
2 stops
GSP12:07 pmGreenville
$396
Find similar
American Airlines
Feb 23
CHS8:06 pmCharleston
17h 44m
2 stops
PTY1:50 pmPanama City Tocumen Intl
Mar 9
PTY3:13 pmPanama City Tocumen Intl
27h 09m
1 stop
CHS7:22 pmCharleston
$402
Find similar

United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets
United Airlines
Mar 31
CHS6:40 amCharleston
8h 34m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Apr 13
PTY10:55 pmPanama City Tocumen Intl
8h 58m
1 stop
CHS8:53 amCharleston
$370
Find similar
United Airlines
Jan 26
CHS11:00 amCharleston
9h 02m
1 stop
PTY8:02 pmPanama City Tocumen Intl
Jan 29
PTY11:35 amPanama City Tocumen Intl
28h 42m
1 stop
CHS4:17 pmCharleston
$378
Find similar
United Airlines
Feb 23
CHS5:07 pmCharleston
24h 00m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Mar 9
PTY3:41 pmPanama City Tocumen Intl
29h 17m
1 stop
CHS9:58 pmCharleston
$386
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 3/31

6:40 am-2:14 pm

1 stop8h 34m

Panama City Tocumen Intl

lun. 4/13

10:55 pm-8:53 am

1 stop8h 58m

$370

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 1/26

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

jue. 1/29

11:35 am-4:17 pm

1 stop28h 42m

$378

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

7:02 pm-2:22 pm

2 stops20h 20m

Panama City Tocumen Intl

mar. 3/17

1:44 pm-10:50 am

2 stops20h 06m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

7:00 pm-3:38 pm

2 stops20h 38m

Panama City Tocumen Intl

mié. 2/4

2:27 pm-12:07 pm

2 stops21h 40m

$396

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 2/19

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

dom. 2/22

5:50 pm-12:22 pm

2 stops18h 32m

$428

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

sáb. 5/2

7:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

jue. 5/21

2:20 pm-11:55 pm

1 stop8h 35m

$456

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

mié. 2/25

7:00 am-12:40 am

2 stops17h 40m

Panama City Tocumen Intl

dom. 3/1

2:55 pm-12:22 pm

2 stops21h 27m

$459

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

mar. 4/7

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

jue. 4/16

2:20 pm-11:55 pm

1 stop8h 35m

$578

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

dom. 2/1

7:33 pm-9:20 am

2 stops37h 47m

Panama City Tocumen Intl

jue. 2/5

10:20 am-6:52 pm

2 stops32h 32m

$1,714

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

dom. 2/1

7:33 pm-9:20 am

2 stops37h 47m

Panama City Tocumen Intl

jue. 2/5

10:20 am-6:52 pm

2 stops32h 32m

$1,722

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $389. If you don’t want to visit Panama in September, then you should wait until March to fly from South Carolina, when ticket prices are also cheap, with an average price of $413.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from South Carolina. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from South Carolina to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 1% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time

6h 55m

Direct flights

None
The fastest flight from South Carolina to Panama takes 6h 55m
There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama?

    Prices for flights from South Carolina to Panama were last updated today.

  • How many operators does momondo search for flights from South Carolina to Panama?

  • How old do you have to be to fly from South Carolina to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $349Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $373Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $382Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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