What is the cheapest airline that flies from South Carolina to Panama?

United Airlines, Delta, and Copa Airlines are the most popular carriers operating from South Carolina to Panama

What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. Delta is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Charleston and flying into Panama City (one of the most popular routes), then the duration is 6h 25m on average. Another popular route from South Carolina to Panama is flying from Greenville to Panama City, which will take roughly 8h 11m. Keep in mind that layovers or delays could extend your travel time.

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of May 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$201 Cheap Flights from South Carolina to Panama in 2026

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Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:30 am - 1:13 pm

CHS

PTY

8h 43m

1 stop

2:21 pm - 8:42 am

PTY

CHS

17h 21m

1 stop

$467Delta

Tue, Sep 8 - Wed, Sep 16

8:14 am - 6:37 pm

CHS

PTY

11h 23m

2 stops

3:30 pm - 10:56 am

PTY

CHS

18h 26m

2 stops

$471United Airlines

Thu, Aug 27 - Mon, Aug 31

7:00 am - 2:14 pm

CHS

PTY

8h 14m

1 stop

3:30 pm - 10:11 pm

PTY

CHS

29h 41m

1 stop

$476United Airlines

Tue, Aug 25 - Wed, Aug 26

11:22 am - 7:31 pm

CLT

PTY

9h 09m

1 stop

9:30 am - 9:33 pm

PTY

CLT

11h 03m

1 stop

$479United Airlines

Tue, Oct 20 - Mon, Oct 26

8:05 am - 4:04 am

CLT

PTY

20h 59m

2 stops

7:55 am - 9:59 pm

PTY

CLT

13h 04m

1 stop

$483United Airlines

Thu, Jul 9 - Thu, Jul 16

7:00 am - 4:04 am

CLT

PTY

22h 04m

1 stop

7:55 am - 9:59 pm

PTY

CLT

13h 04m

1 stop

$486United Airlines

Thu, Jul 9 - Thu, Jul 16

5:55 am - 2:10 pm

GSP

PTY

9h 15m

1 stop

3:35 pm - 11:14 pm

PTY

GSP

6h 39m

1 stop

$507American Airlines

Tue, Sep 15 - Thu, Oct 15

8:24 pm - 2:10 pm

GSP

PTY

18h 46m

2 stops

3:35 pm - 12:18 pm

PTY

GSP

19h 43m

2 stops

$511American Airlines

Tue, Sep 15 - Thu, Oct 15

6:15 am - 8:58 am

SAV

DAV

27h 43m

2 stops

9:50 am - 9:55 pm

DAV

SAV

35h 05m

2 stops

$1,038Copa Airlines

Thu, May 28 - Mon, Jun 1

6:15 am - 8:58 am

SAV

DAV

27h 43m

2 stops

9:38 am - 11:52 pm

DAV

SAV

37h 14m

2 stops

$1,118Multiple Airlines

Wed, May 27 - Sun, May 31

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Sep 8

CHS6:30 amCharleston

7h 43m

1 stop

PTY1:13 pmPanama City Tocumen Intl

Sep 15

PTY2:21 pmPanama City Tocumen Intl

17h 21m

1 stop

CHS8:42 amCharleston

$467

Delta

Sep 10

CHS5:30 amCharleston

8h 26m

1 stop

PTY12:56 pmPanama City Tocumen Intl

Sep 19

PTY2:21 pmPanama City Tocumen Intl

8h 36m

1 stop

CHS11:57 pmCharleston

$501

Delta

Aug 12

GSP5:46 amGreenville

8h 09m

1 stop

PTY12:55 pmPanama City Tocumen Intl

Aug 20

PTY2:20 pmPanama City Tocumen Intl

7h 39m

1 stop

GSP10:59 pmGreenville

$507

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets

American Airlines

Sep 15

GSP8:24 pmGreenville

18h 46m

2 stops

PTY2:10 pmPanama City Tocumen Intl

Oct 15

PTY3:35 pmPanama City Tocumen Intl

19h 43m

2 stops

GSP12:18 pmGreenville

$511

American Airlines

Sep 15

GSP5:55 amGreenville

9h 15m

1 stop

PTY2:10 pmPanama City Tocumen Intl

Oct 15

PTY3:35 pmPanama City Tocumen Intl

6h 39m

1 stop

GSP11:14 pmGreenville

$523

American Airlines

Aug 5

CHS6:00 amCharleston

7h 24m

1 stop

PTY12:24 pmPanama City Tocumen Intl

Aug 9

PTY1:24 pmPanama City Tocumen Intl

26h 01m

1 stop

CHS4:25 pmCharleston

$526

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 9/8

5:30 am-1:13 pm

1 stop8h 43m

Panama City Tocumen Intl

Wed 9/16

2:21 pm-8:42 am

1 stop17h 21m

$467

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 8/27

8:14 am-6:37 pm

2 stops11h 23m

Panama City Tocumen Intl

Mon 8/31

3:30 pm-10:56 am

2 stops18h 26m

$471

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 8/25

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Wed 8/26

3:30 pm-10:11 pm

1 stop29h 41m

$476

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 10/20

11:22 am-7:31 pm

1 stop9h 09m

Panama City Tocumen Intl

Mon 10/26

9:30 am-9:33 pm

1 stop11h 03m

$479

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/9

8:05 am-4:04 am

2 stops20h 59m

Panama City Tocumen Intl

Thu 7/16

7:55 am-9:59 pm

1 stop13h 04m

$483

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/9

7:00 am-4:04 am

1 stop22h 04m

Panama City Tocumen Intl

Thu 7/16

7:55 am-9:59 pm

1 stop13h 04m

$486

Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

5:55 am-2:10 pm

1 stop9h 15m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$507

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

8:24 pm-2:10 pm

2 stops18h 46m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-12:18 pm

2 stops19h 43m

$511

SavannahDavid

SAV - DAV

SAVDAV

Savannah/Hilton Head

Thu 5/28

6:15 am-8:58 am

2 stops27h 43m

David Enrique Malek

Mon 6/1

9:50 am-9:55 pm

2 stops35h 05m

$1,038

SavannahDavid

SAV - DAV

SAVDAV

Savannah/Hilton Head

Wed 5/27

6:15 am-8:58 am

2 stops27h 43m

David Enrique Malek

Sun 5/31

9:38 am-11:52 pm

2 stops37h 14m

$1,118

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of July is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $172. If you don’t want to visit Panama in July, then you should wait until October to fly from South Carolina, when ticket prices are also cheap, with an average price of $309.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time	6h 25m
Direct flights	None

The fastest flight from South Carolina to Panama takes 6h 25m

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

Frequently asked questions about flying from South Carolina to Panama

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of May 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $309	Free Cancellation	Rating 7.9 8,454 reviews	Search Delta flights
United Airlines	PriceFrom $369	Free Cancellation	Rating 7.4 9,711 reviews	Search United Airlines flights
American Airlines	PriceFrom $373	Free Cancellation	Rating 7.1 11,664 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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Flights to Panama Cityfrom $355

Flights to Bocas del Torofrom $686

Flights to Davidfrom $420

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Cheap flights from South Carolina to Panama from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

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Our best American Airlines deals on South Carolina to Panama flight tickets

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How to get the cheapest flight ticket from South Carolina to Panama

What is the cheapest month to fly to Panama?

Can stopping save me money on South Carolina to Panama flights?

What is the cheapest airline that flies from South Carolina to Panama?

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time

Direct flights

Frequently asked questions about flying from South Carolina to Panama

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

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Explore popular destinations other users love

According to popular flight searches on momondo this year