What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Myrtle Beach and flying into Panama City (one of the most popular routes), then the duration is 8h 35m on average. Another popular route from South Carolina to Panama is flying from Greenville to Panama City, which will take roughly 8h 35m. Keep in mind that layovers or delays could extend your travel time.

What is the cheapest airline that flies from South Carolina to Panama?

JetBlue, United Airlines, and American Airlines are the most popular carriers operating from South Carolina to Panama

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of August 2026, there are 4 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$250 Cheap Flights from South Carolina to Panama in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:25 pm - 6:55 pmCHS Charleston-PTY Panama City Tocumen Intl

22h 30m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

7:50 pm - 10:25 amPTY Panama City Tocumen Intl-CHS Charleston

14h 35m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$553Multiple Airlines

Mon, Nov 16 - Mon, Nov 23

8:25 pm - 10:30 amCHS Charleston-PTY Panama City Tocumen Intl

15h 05m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

7:50 pm - 9:59 amPTY Panama City Tocumen Intl-CHS Charleston

13h 09m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$553Multiple Airlines

Fri, Oct 23 - Sun, Oct 25

5:30 am - 2:05 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

8h 35m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 11:54 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

8h 24m1 stop Atlanta Hartsfield-Jackson

$559Delta

Thu, Dec 10 - Mon, Dec 14

8:25 pm - 10:30 amCHS Charleston-PTY Panama City Tocumen Intl

15h 05m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

11:25 am - 9:59 amPTY Panama City Tocumen Intl-CHS Charleston

21h 34m3 stops San José Juan Santamaria Intl Guatemala City La Aurora New York John F Kennedy Intl

$559Multiple Airlines

Fri, Oct 23 - Sun, Oct 25

5:30 am - 2:05 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

8h 35m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 11:54 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

8h 24m1 stop Atlanta Hartsfield-Jackson

$579Delta

Thu, Dec 10 - Mon, Dec 14

11:00 am - 7:31 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

9h 31m1 stop Newark

8:55 am - 9:59 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

13h 04m1 stop Houston George Bush Intcntl

$579United Airlines

Wed, Oct 21 - Wed, Nov 18

11:00 am - 7:31 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

9h 31m1 stop Newark

8:55 am - 9:59 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

13h 04m1 stop Houston George Bush Intcntl

$579United Airlines

Tue, Oct 20 - Tue, Nov 3

10:44 pm - 1:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

15h 18m1 stop Miami

2:02 pm - 8:24 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

17h 22m1 stop Miami

$579American Airlines

Mon, Oct 26 - Thu, Oct 29

10:44 pm - 1:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

15h 18m1 stop Miami

2:02 pm - 8:24 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

17h 22m1 stop Miami

$579American Airlines

Mon, Oct 12 - Fri, Oct 16

5:30 am - 2:05 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

8h 35m1 stop Atlanta Hartsfield-Jackson

8:00 am - 8:18 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

12h 18m1 stop Atlanta Hartsfield-Jackson

$599Delta

Thu, Dec 10 - Tue, Dec 22

Cheap last minute flights

Enter your travel dates to find the best prices.

7:00 am - 7:31 pmGSP Greenville-PTY Panama City Tocumen Intl

13h 31m1 stop Newark

10:55 pm - 10:37 amPTY Panama City Tocumen Intl-GSP Greenville

10h 42m1 stop Newark

$745United Airlines

Tue, Aug 18 - Wed, Aug 26

7:00 am - 6:37 pmGSP Greenville-PTY Panama City Tocumen Intl

12h 37m1 stop Houston George Bush Intcntl

10:00 am - 9:58 pmPTY Panama City Tocumen Intl-GSP Greenville

10h 58m1 stop Houston George Bush Intcntl

$745United Airlines

Mon, Aug 17 - Wed, Aug 26

6:55 am - 12:55 pmGSP Greenville-PTY Panama City Tocumen Intl

7h 00m1 stop Atlanta Hartsfield-Jackson

2:20 pm - 10:59 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 39m1 stop Atlanta Hartsfield-Jackson

$745Delta

Tue, Aug 18 - Tue, Aug 25

6:55 am - 12:55 pmGSP Greenville-PTY Panama City Tocumen Intl

7h 00m1 stop Atlanta Hartsfield-Jackson

2:20 pm - 10:59 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 39m1 stop Atlanta Hartsfield-Jackson

$745Delta

Wed, Aug 19 - Tue, Aug 25

11:25 am - 4:04 amGSP Greenville-PTY Panama City Tocumen Intl

17h 39m1 stop Newark

10:55 pm - 10:37 amPTY Panama City Tocumen Intl-GSP Greenville

10h 42m1 stop Newark

$745United Airlines

Wed, Aug 19 - Wed, Aug 26

6:00 am - 12:39 pmSAV Savannah/Hilton Head-PTY Panama City Tocumen Intl

7h 39m1 stop Miami

1:39 pm - 11:59 pmPTY Panama City Tocumen Intl-SAV Savannah/Hilton Head

9h 20m1 stop Miami

$949American Airlines

Sun, Aug 16 - Mon, Aug 17

6:00 am - 12:39 pmSAV Savannah/Hilton Head-PTY Panama City Tocumen Intl

7h 39m1 stop Miami

1:39 pm - 11:59 amPTY Panama City Tocumen Intl-SAV Savannah/Hilton Head

21h 20m2 stops Miami Dallas/Fort Worth

$953American Airlines

Sun, Aug 16 - Mon, Aug 17

7:55 pm - 6:13 amCLT Charlotte Douglas-PTY Panama City Tocumen Intl

11h 18m1 stop Washington, D.C. Dulles Intl

6:41 pm - 9:44 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

14h 03m1 stop Washington, D.C. Dulles Intl

$965Copa Airlines

Mon, Aug 17 - Sat, Aug 22

10:25 am - 8:35 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

11h 10m1 stop Washington, D.C. Dulles Intl

6:41 pm - 9:44 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

14h 03m1 stop Washington, D.C. Dulles Intl

$965Copa Airlines

Mon, Aug 17 - Sat, Aug 22

9:43 am - 1:55 amSAV Savannah/Hilton Head-PTY Panama City Tocumen Intl

17h 12m2 stops Boston Logan Intl San Salvador El Salvador Intl

3:50 pm - 10:04 amPTY Panama City Tocumen Intl-SAV Savannah/Hilton Head

41h 14m2 stops San Salvador El Salvador Intl Boston Logan Intl

$1,079Multiple Airlines

Sun, Aug 16 - Mon, Aug 17

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United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets

United Airlines

Oct 20

CLT6:45 amCharlotte Douglas

13h 46m

2 stops

PTY7:31 pmPanama City Tocumen Intl

Nov 3

PTY4:41 pmPanama City Tocumen Intl

21h 01m

2 stops

CLT1:42 pmCharlotte Douglas

$583

United Airlines

Oct 14

CHS7:00 amCharleston

12h 37m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 21

PTY10:00 amPanama City Tocumen Intl

11h 21m

1 stop

CHS10:21 pmCharleston

$597

United Airlines

Oct 1

CHS6:00 amCharleston

14h 31m

2 stops

PTY7:31 pmPanama City Tocumen Intl

Oct 5

PTY3:30 pmPanama City Tocumen Intl

17h 57m

2 stops

CHS10:27 amCharleston

$601

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Dec 10

CLT5:30 amCharlotte Douglas

8h 35m

1 stop

PTY2:05 pmPanama City Tocumen Intl

Dec 14

PTY3:30 pmPanama City Tocumen Intl

8h 24m

1 stop

CLT11:54 pmCharlotte Douglas

$559

Delta

Dec 10

CLT5:30 amCharlotte Douglas

8h 35m

1 stop

PTY2:05 pmPanama City Tocumen Intl

Dec 14

PTY3:30 pmPanama City Tocumen Intl

8h 24m

1 stop

CLT11:54 pmCharlotte Douglas

$579

Delta

Dec 10

CLT5:30 amCharlotte Douglas

8h 35m

1 stop

PTY2:05 pmPanama City Tocumen Intl

Dec 24

PTY3:25 pmPanama City Tocumen Intl

8h 28m

1 stop

CLT11:53 pmCharlotte Douglas

$599

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Mon 11/16

8:25 pm-6:55 pm

2 stops22h 30m

Panama City Tocumen Intl

Mon 11/23

7:50 pm-10:25 am

2 stops14h 35m

$553

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Fri 10/23

8:25 pm-10:30 am

2 stops15h 05m

Panama City Tocumen Intl

Sun 10/25

7:50 pm-9:59 am

2 stops13h 09m

$553

Quickest round-trip

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

5:30 am-2:05 pm

1 stop8h 35m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-11:54 pm

1 stop8h 24m

$559

CharlestonPanama City

CHS Charleston - PTY Panama City Tocumen Intl

CHSPTY

Charleston

Fri 10/23

8:25 pm-10:30 am

2 stops15h 05m

Panama City Tocumen Intl

Sun 10/25

11:25 am-9:59 am

3 stops21h 34m

$559

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

5:30 am-2:05 pm

1 stop8h 35m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-11:54 pm

1 stop8h 24m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Wed 10/21

11:00 am-7:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Wed 11/18

8:55 am-9:59 pm

1 stop13h 04m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Tue 10/20

11:00 am-7:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Tue 11/3

8:55 am-9:59 pm

1 stop13h 04m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Mon 10/26

10:44 pm-1:02 pm

1 stop15h 18m

Panama City Tocumen Intl

Thu 10/29

2:02 pm-8:24 am

1 stop17h 22m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Mon 10/12

10:44 pm-1:02 pm

1 stop15h 18m

Panama City Tocumen Intl

Fri 10/16

2:02 pm-8:24 am

1 stop17h 22m

$579

CharlottePanama City

CLT Charlotte Douglas - PTY Panama City Tocumen Intl

CLTPTY

Charlotte Douglas

Thu 12/10

5:30 am-2:05 pm

1 stop8h 35m

Panama City Tocumen Intl

Tue 12/22

8:00 am-8:18 pm

1 stop12h 18m

$599

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $487. If you don’t want to visit Panama in March, then you should wait until October to fly from South Carolina, when ticket prices are also cheap, with an average price of $523.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 1% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time	7h 59m
Direct flights	None

The fastest flight from South Carolina to Panama takes 7h 59m

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

Frequently asked questions about flying from South Carolina to Panama

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of August 2026, there are 4 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $363	Free Cancellation	Rating 7.1 11,941 reviews	Search American Airlines flights
United Airlines	PriceFrom $369	Free Cancellation	Rating 7.4 10,111 reviews	Search United Airlines flights
Delta	PriceFrom $390	Free Cancellation	Rating 7.8 8,508 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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Popular cities in Panama

Flights to Panama Cityfrom $446

Flights to Bocas del Torofrom $721

Flights to Davidfrom $440

Flights to Changuinola

Cheap flights from South Carolina to Panama from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 8/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

What is the cheapest month to fly to Panama?

Can stopping save me money on South Carolina to Panama flights?

What is the cheapest airline that flies from South Carolina to Panama?

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Fastest flight time

Direct flights

Frequently asked questions about flying from South Carolina to Panama

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

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According to popular flight searches on momondo this year