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Cheap flights from South Carolina to Panama from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 3/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:40 pm - 4:04 am
CHS
-
PTY
9h 24m
1 stop
United Airlines Logo
7:55 am - 9:59 pm
PTY
-
CHS
13h 04m
1 stop
$391United Airlines
Thu, Apr 16 - Mon, Apr 20
American Airlines Logo
6:00 am - 12:40 pm
CHS
-
PTY
7h 40m
1 stop
American Airlines Logo
1:40 pm - 12:42 pm
PTY
-
CHS
22h 02m
2 stops
$395American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
6:00 am - 2:20 pm
CHS
-
PTY
9h 20m
1 stop
American Airlines Logo
3:51 pm - 11:59 pm
PTY
-
CHS
7h 08m
1 stop
$409American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
8:45 pm - 12:46 pm
CLT
-
PTY
17h 01m
1 stop
American Airlines Logo
1:49 pm - 10:57 pm
PTY
-
CLT
8h 08m
1 stop
$409American Airlines
Mon, Apr 20 - Thu, Apr 23
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
19h 00m
2 stops
Multiple Airlines Logo
5:50 pm - 12:07 pm
PTY
-
CLT
17h 17m
2 stops
$423Multiple Airlines
Tue, Mar 10 - Tue, Mar 17
Azul Logo
6:12 am - 8:02 pm
GSP
-
PTY
13h 50m
1 stop
Azul Logo
9:30 am - 11:59 pm
PTY
-
GSP
13h 29m
1 stop
$429Azul
Wed, Feb 25 - Wed, Mar 11
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
19h 00m
2 stops
Multiple Airlines Logo
5:50 pm - 12:07 pm
PTY
-
CLT
17h 17m
2 stops
$448Multiple Airlines
Tue, Mar 10 - Tue, Mar 17
Copa Airlines Logo
12:07 pm - 7:31 pm
GSP
-
PTY
8h 24m
1 stop
Copa Airlines Logo
7:55 am - 10:14 pm
PTY
-
GSP
13h 19m
1 stop
$459Copa Airlines
Sat, May 2 - Sat, May 9
LATAM Airlines Logo
6:50 am - 1:03 pm
CAE
-
PTY
7h 13m
1 stop
LATAM Airlines Logo
2:27 pm - 11:29 am
PTY
-
CAE
20h 02m
1 stop
$463LATAM Airlines
Tue, Mar 31 - Thu, Apr 16
LATAM Airlines Logo
6:50 am - 1:03 pm
CAE
-
PTY
7h 13m
1 stop
LATAM Airlines Logo
2:27 pm - 11:29 am
PTY
-
CAE
20h 02m
1 stop
$483LATAM Airlines
Tue, Mar 31 - Fri, Apr 17

United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets
United Airlines
Apr 16
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 20
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$391
United Airlines
Apr 16
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 19
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$411
United Airlines
Mar 7
CHS7:01 pmCharleston
10h 09m
1 stop
PTY5:10 amPanama City Tocumen Intl
Mar 9
PTY3:41 pmPanama City Tocumen Intl
23h 27m
1 stop
CHS4:08 pmCharleston
$419

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets
American Airlines
Mar 24
CHS6:09 pmCharleston
21h 11m
2 stops
PTY2:20 pmPanama City Tocumen Intl
Mar 31
PTY1:40 pmPanama City Tocumen Intl
17h 53m
2 stops
CHS8:33 amCharleston
$395
American Airlines
Mar 24
CHS6:00 amCharleston
9h 20m
1 stop
PTY2:20 pmPanama City Tocumen Intl
Mar 31
PTY3:51 pmPanama City Tocumen Intl
7h 08m
1 stop
CHS11:59 pmCharleston
$409
American Airlines
May 1
CLT7:09 amCharlotte Douglas
6h 37m
1 stop
PTY12:46 pmPanama City Tocumen Intl
May 6
PTY1:49 pmPanama City Tocumen Intl
15h 37m
2 stops
CLT6:26 amCharlotte Douglas
$413

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 4/16

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Mon 4/20

7:55 am-9:59 pm

1 stop13h 04m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/24

6:00 am-12:40 pm

1 stop7h 40m

Panama City Tocumen Intl

Tue 3/31

1:40 pm-12:42 pm

2 stops22h 02m

$395

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/24

6:00 am-2:20 pm

1 stop9h 20m

Panama City Tocumen Intl

Tue 3/31

3:51 pm-11:59 pm

1 stop7h 08m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 4/20

8:45 pm-12:46 pm

1 stop17h 01m

Panama City Tocumen Intl

Thu 4/23

1:49 pm-10:57 pm

1 stop8h 08m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/10

7:00 am-1:00 am

2 stops19h 00m

Panama City Tocumen Intl

Tue 3/17

5:50 pm-12:07 pm

2 stops17h 17m

$423

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 2/25

6:12 am-8:02 pm

1 stop13h 50m

Panama City Tocumen Intl

Wed 3/11

9:30 am-11:59 pm

1 stop13h 29m

$429

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/10

7:00 am-1:00 am

2 stops19h 00m

Panama City Tocumen Intl

Tue 3/17

5:50 pm-12:07 pm

2 stops17h 17m

$448

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/2

12:07 pm-7:31 pm

1 stop8h 24m

Panama City Tocumen Intl

Sat 5/9

7:55 am-10:14 pm

1 stop13h 19m

$459

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Tue 3/31

6:50 am-1:03 pm

1 stop7h 13m

Panama City Tocumen Intl

Thu 4/16

2:27 pm-11:29 am

1 stop20h 02m

$463

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Tue 3/31

6:50 am-1:03 pm

1 stop7h 13m

Panama City Tocumen Intl

Fri 4/17

2:27 pm-11:29 am

1 stop20h 02m

$483

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $373. If you don’t want to visit Panama in March, then you should wait until September to fly from South Carolina, when ticket prices are also cheap, with an average price of $389.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 2% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time

7h 07m

Direct flights

None
The fastest flight from South Carolina to Panama takes 7h 07m
There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama?

    Prices for flights from South Carolina to Panama were last updated today.

  • How many operators does momondo search for flights from South Carolina to Panama?

  • How old do you have to be to fly from South Carolina to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $309Free CancellationRating
7.9
8,176 reviews
Search Delta flights
American AirlinesPriceFrom $363Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,262 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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