What is the cheapest airline that flies from South Carolina to Panama?

Delta, American Airlines, and United Airlines are the most popular carriers operating from South Carolina to Panama

What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from South Carolina according to our data. Delta is the first choice among our users, with 54% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

How long is the flight from South Carolina to Panama?

Flight times from South Carolina to Panama vary, but if you’re flying out of Columbia and flying into Panama City (one of the most popular routes), then the duration is 7h 13m on average. Another popular route from South Carolina to Panama is flying from Greenville to Panama City, which will take roughly 8h 14m. Keep in mind that layovers or delays could extend your travel time.

When did momondo last update prices for flights from South Carolina to Panama?

Prices for flights from South Carolina to Panama were last updated today.

How many operators does momondo search for flights from South Carolina to Panama?

As of March 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.

How old do you have to be to fly from South Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$189 Cheap Flights from South Carolina to Panama in 2026

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Find the cheapest flights from South Carolina to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:30 am - 12:35 am

CLT

PTY

19h 05m

2 stops

3:10 pm - 11:45 am

PTY

CLT

19h 35m

2 stops

$394Multiple Airlines

jue., abr. 23 - dom., abr. 26

6:30 am - 12:35 am

CLT

PTY

19h 05m

2 stops

5:30 am - 11:45 am

PTY

CLT

29h 15m

3 stops

$396Multiple Airlines

jue., abr. 23 - sáb., may. 9

6:30 am - 12:35 am

CLT

PTY

19h 05m

2 stops

4:25 am - 11:45 am

PTY

CLT

30h 20m

2 stops

$407Multiple Airlines

jue., abr. 23 - sáb., may. 9

5:05 am - 12:46 pm

CLT

PTY

8h 41m

1 stop

1:14 pm - 6:22 am

PTY

CLT

16h 08m

2 stops

$440American Airlines

vie., may. 15 - vie., may. 22

5:17 am - 2:20 pm

CLT

PTY

10h 03m

1 stop

3:20 pm - 8:25 am

PTY

CLT

16h 05m

1 stop

$449American Airlines

mié., ago. 12 - mié., ago. 19

6:50 am - 6:37 pm

CHS

PTY

12h 47m

1 stop

10:00 am - 10:15 pm

PTY

CHS

11h 15m

1 stop

$467United Airlines

jue., jun. 18 - mié., jul. 1

6:50 am - 6:37 pm

CHS

PTY

12h 47m

1 stop

10:55 pm - 9:48 pm

PTY

CHS

21h 53m

2 stops

$471United Airlines

jue., jun. 18 - mié., jul. 1

5:45 am - 12:56 pm

GSP

PTY

8h 11m

1 stop

2:21 pm - 11:37 pm

PTY

GSP

8h 16m

1 stop

$497Delta

mar., sep. 22 - jue., oct. 8

6:51 am - 1:02 pm

GSP

PTY

7h 11m

1 stop

2:27 pm - 11:56 pm

PTY

GSP

8h 29m

1 stop

$521Delta

sáb., may. 2 - mié., may. 6

5:40 am - 1:02 pm

AGS

PTY

8h 22m

1 stop

2:27 pm - 9:16 am

PTY

AGS

17h 49m

1 stop

$643LATAM Airlines

lun., abr. 27 - lun., may. 4

United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets

United Airlines

Jun 18

CHS6:50 amCharleston

12h 47m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Jul 1

PTY10:00 amPanama City Tocumen Intl

11h 15m

1 stop

CHS10:15 pmCharleston

$467

United Airlines

Jun 18

CHS6:50 amCharleston

12h 47m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Jul 1

PTY10:55 pmPanama City Tocumen Intl

21h 53m

2 stops

CHS9:48 pmCharleston

$471

United Airlines

May 13

CHS6:35 amCharleston

10h 37m

1 stop

PTY4:12 pmPanama City Tocumen Intl

May 20

PTY3:30 pmPanama City Tocumen Intl

29h 45m

1 stop

CHS10:15 pmCharleston

$476

Delta flights from South Carolina to Panama

Our best Delta deals on South Carolina to Panama flight tickets

Delta

Sep 22

GSP5:45 amGreenville

8h 11m

1 stop

PTY12:56 pmPanama City Tocumen Intl

Oct 8

PTY2:21 pmPanama City Tocumen Intl

8h 16m

1 stop

GSP11:37 pmGreenville

$497

Delta

Apr 13

CLT5:30 amCharlotte Douglas

8h 32m

1 stop

PTY1:02 pmPanama City Tocumen Intl

Apr 27

PTY2:27 pmPanama City Tocumen Intl

8h 26m

1 stop

CLT11:53 pmCharlotte Douglas

$499

Delta

Apr 13

CLT5:30 amCharlotte Douglas

8h 32m

1 stop

PTY1:02 pmPanama City Tocumen Intl

Apr 27

PTY2:27 pmPanama City Tocumen Intl

8h 26m

1 stop

CLT11:53 pmCharlotte Douglas

$519

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 4/23

6:30 am-12:35 am

2 stops19h 05m

Panama City Tocumen Intl

dom. 4/26

3:10 pm-11:45 am

2 stops19h 35m

$394

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 4/23

6:30 am-12:35 am

2 stops19h 05m

Panama City Tocumen Intl

sáb. 5/9

5:30 am-11:45 am

3 stops29h 15m

$396

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 4/23

6:30 am-12:35 am

2 stops19h 05m

Panama City Tocumen Intl

sáb. 5/9

4:25 am-11:45 am

2 stops30h 20m

$407

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

vie. 5/15

5:05 am-12:46 pm

1 stop8h 41m

Panama City Tocumen Intl

vie. 5/22

1:14 pm-6:22 am

2 stops16h 08m

$440

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

mié. 8/12

5:17 am-2:20 pm

1 stop10h 03m

Panama City Tocumen Intl

mié. 8/19

3:20 pm-8:25 am

1 stop16h 05m

$449

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

jue. 6/18

6:50 am-6:37 pm

1 stop12h 47m

Panama City Tocumen Intl

mié. 7/1

10:00 am-10:15 pm

1 stop11h 15m

$467

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

jue. 6/18

6:50 am-6:37 pm

1 stop12h 47m

Panama City Tocumen Intl

mié. 7/1

10:55 pm-9:48 pm

2 stops21h 53m

$471

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mar. 9/22

5:45 am-12:56 pm

1 stop8h 11m

Panama City Tocumen Intl

jue. 10/8

2:21 pm-11:37 pm

1 stop8h 16m

$497

Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

sáb. 5/2

6:51 am-1:02 pm

1 stop7h 11m

Panama City Tocumen Intl

mié. 5/6

2:27 pm-11:56 pm

1 stop8h 29m

$521

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

lun. 4/27

5:40 am-1:02 pm

1 stop8h 22m

Panama City Tocumen Intl

lun. 5/4

2:27 pm-9:16 am

1 stop17h 49m

$643

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $389. If you don’t want to visit Panama in September, then you should wait until May to fly from South Carolina, when ticket prices are also cheap, with an average price of $440.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time	6h 13m
Direct flights	None

The fastest flight from South Carolina to Panama takes 6h 13m

There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.

Search flight deals

When did momondo last update prices for flights from South Carolina to Panama?
Prices for flights from South Carolina to Panama were last updated today.
How many operators does momondo search for flights from South Carolina to Panama?
As of March 2026, there are 3 operators available to choose from for flights from South Carolina to Panama.
How old do you have to be to fly from South Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $309	Free Cancellation	Rating 7.9 8,359 reviews	Search Delta flights
American Airlines	PriceFrom $363	Free Cancellation	Rating 7.1 11,521 reviews	Search American Airlines flights
United Airlines	PriceFrom $369	Free Cancellation	Rating 7.4 9,509 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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Popular cities in Panama

Flights to Panama Cityfrom $284

Flights to Davidfrom $344

Flights to Bocas del Torofrom $742

Flights to Changuinola

Cheap flights from South Carolina to Panama from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 4/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets

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Our best Delta deals on South Carolina to Panama flight tickets

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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

What is the cheapest month to fly to Panama?

Can stopping save me money on South Carolina to Panama flights?

What is the cheapest airline that flies from South Carolina to Panama?

What airlines fly to Panama?

How long is the flight from South Carolina to Panama?

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Fastest flight time

Direct flights

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

South Carolina flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

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Explore popular destinations other users love

According to popular flight searches on momondo this year