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Cheap flights from South Carolina to Panama from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:35 am - 7:38 pmCHS-PTY
13h 03m1 stop
United Airlines Logo
8:55 am - 9:58 pmPTY-CHS
13h 03m1 stop
$390United Airlines
Find Deal
Mon, Feb 16 - Sun, Feb 22
United Airlines Logo
6:40 am - 7:38 pmGSP-PTY
12h 58m1 stop
United Airlines Logo
11:35 am - 9:57 pmPTY-GSP
10h 22m1 stop
$392United Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
6:31 pm - 12:10 pmCHS-PTY
18h 39m2 stops
American Airlines Logo
1:50 pm - 11:13 amPTY-CHS
20h 23m2 stops
$394American Airlines
Find Deal
Sat, Mar 14 - Tue, Mar 24
American Airlines Logo
6:23 pm - 3:38 pmGSP-PTY
21h 15m2 stops
American Airlines Logo
2:27 pm - 11:57 pmPTY-GSP
9h 30m1 stop
$396American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
United Airlines Logo
7:25 pm - 4:10 amCHS-PTY
9h 45m1 stop
United Airlines Logo
3:41 pm - 9:52 pmPTY-CHS
29h 11m1 stop
$398United Airlines
Find Deal
Sat, Mar 14 - Tue, Mar 17
American Airlines Logo
7:42 pm - 1:27 pmCHS-PTY
17h 45m2 stops
American Airlines Logo
4:50 pm - 8:47 amPTY-CHS
15h 57m1 stop
$399American Airlines
Find Deal
Thu, Feb 5 - Sun, Feb 8
Delta Logo
10:07 am - 2:12 pmGSP-PTY
28h 05m1 stop
Delta Logo
3:37 pm - 11:45 pmPTY-GSP
8h 08m1 stop
$410Delta
Find Deal
Sun, Nov 16 - Mon, Nov 24
Delta Logo
9:54 am - 2:02 pmCLT-PTY
28h 08m1 stop
Delta Logo
3:27 pm - 8:42 amPTY-CLT
17h 15m1 stop
$412Delta
Find Deal
Tue, Feb 17 - Thu, Feb 26
Multiple Airlines Logo
9:38 pm - 2:00 pmCLT-PTY
16h 22m2 stops
Multiple Airlines Logo
5:50 pm - 1:00 pmPTY-CLT
19h 10m2 stops
$429Multiple Airlines
Find Deal
Fri, Nov 14 - Tue, Nov 18
Multiple Airlines Logo
8:52 pm - 8:06 amCLT-PTY
11h 14m1 stop
Multiple Airlines Logo
6:34 pm - 9:18 amPTY-CLT
14h 44m1 stop
$450Multiple Airlines
Find Deal
Sun, Nov 23 - Thu, Nov 27

United Airlines flights from South Carolina to Panama

Our best United Airlines deals on South Carolina to Panama flight tickets
United Airlines
Feb 16
CHS6:35 amCharleston
13h 03m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 22
PTY8:55 amPanama City Tocumen Intl
13h 03m
1 stop
CHS9:58 pmCharleston
$390
Find similar
United Airlines
Jan 21
GSP6:40 amGreenville
12h 58m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 4
PTY11:35 amPanama City Tocumen Intl
10h 22m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
Mar 14
CHS7:25 pmCharleston
9h 45m
1 stop
PTY4:10 amPanama City Tocumen Intl
Mar 17
PTY3:41 pmPanama City Tocumen Intl
29h 11m
1 stop
CHS9:52 pmCharleston
$398
Find similar

American Airlines flights from South Carolina to Panama

Our best American Airlines deals on South Carolina to Panama flight tickets
American Airlines
Mar 14
CHS6:31 pmCharleston
18h 39m
2 stops
PTY12:10 pmPanama City Tocumen Intl
Mar 24
PTY1:50 pmPanama City Tocumen Intl
20h 23m
2 stops
CHS11:13 amCharleston
$394
Find similar
American Airlines
Jan 21
GSP6:23 pmGreenville
21h 15m
2 stops
PTY3:38 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
9h 30m
1 stop
GSP11:57 pmGreenville
$396
Find similar
American Airlines
Feb 5
CHS7:42 pmCharleston
17h 45m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Feb 8
PTY4:50 pmPanama City Tocumen Intl
15h 57m
1 stop
CHS8:47 amCharleston
$399
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 2/16

6:35 am-7:38 pm

1 stop13h 03m

Panama City Tocumen Intl

Sun 2/22

8:55 am-9:58 pm

1 stop13h 03m

$390

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:40 am-7:38 pm

1 stop12h 58m

Panama City Tocumen Intl

Wed 2/4

11:35 am-9:57 pm

1 stop10h 22m

$392

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:31 pm-12:10 pm

2 stops18h 39m

Panama City Tocumen Intl

Tue 3/24

1:50 pm-11:13 am

2 stops20h 23m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:23 pm-3:38 pm

2 stops21h 15m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$396

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

7:25 pm-4:10 am

1 stop9h 45m

Panama City Tocumen Intl

Tue 3/17

3:41 pm-9:52 pm

1 stop29h 11m

$398

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 2/5

7:42 pm-1:27 pm

2 stops17h 45m

Panama City Tocumen Intl

Sun 2/8

4:50 pm-8:47 am

1 stop15h 57m

$399

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 11/16

10:07 am-2:12 pm

1 stop28h 05m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-11:45 pm

1 stop8h 08m

$410

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

9:54 am-2:02 pm

1 stop28h 08m

Panama City Tocumen Intl

Thu 2/26

3:27 pm-8:42 am

1 stop17h 15m

$412

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 11/14

9:38 pm-2:00 pm

2 stops16h 22m

Panama City Tocumen Intl

Tue 11/18

5:50 pm-1:00 pm

2 stops19h 10m

$429

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 11/23

8:52 pm-8:06 am

1 stop11h 14m

Panama City Tocumen Intl

Thu 11/27

6:34 pm-9:18 am

1 stop14h 44m

$450

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from South Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from South Carolina, with most prices found around $389. If you don’t want to visit Panama in September, then you should wait until November to fly from South Carolina, when ticket prices are also cheap, with an average price of $430.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from South Carolina. The lowest ticket price found for a Wednesday departure recently was $341. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Panama for around $712.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from South Carolina to Panama when you can find flight prices for as low as $466. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $495 per ticket.

Can stopping save me money on South Carolina to Panama flights?

You could potentially save up to 17% on your flight if you consider stops on a South Carolina to Panama flight.

Cheap South Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama

Direct flights

None
There are no direct flights from South Carolina to Panama. There are no popular flight routes from South Carolina to Panama.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama?

    Prices for flights from South Carolina to Panama were last updated today.

  • How many operators does momondo search for flights from South Carolina to Panama?

  • How old do you have to be to fly from South Carolina to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Panama

Compare and see reviews for airlines that fly from South Carolina to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $369Free CancellationRating
7.9
8,003 reviews
Search Delta flights
United AirlinesPriceFrom $383Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama?

It is quick and easy to find South Carolina to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from South Carolina to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Panama?

Once all potential South Carolina to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Panama right now. Can momondo alert me if prices change?

Price alerts on flights to Panama from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama trip

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