Cheap flights from Santiago to Santa Cruz de la Sierra from $143

The cheapest month to fly to Santa Cruz de la Sierra from Santiago is in October. Flight prices, which tend to average around $379, are often lower during this time because this is during the off-season. If you don’t want to visit Santa Cruz de la Sierra in October, then you should wait until June to fly from Santiago, when ticket prices are also cheap, with an average price of $383.

The cheapest day to depart on your flight to Santa Cruz de la Sierra is on a Monday when prices can be found for as low as $337. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santa Cruz de la Sierra on Wednesday is $409.

In the morning is the cheapest time of day to fly from Santiago to Santa Cruz de la Sierra when you can find flight prices for as low as $323. Flying to Santa Cruz de la Sierra in the morning is an ideal time because this is during off-peak travel hours. Flights in the evening are often more expensive with an average ticket price of $409.

Fly from Santiago Arturo Merino Benitez to Santa Cruz de la Sierra Viru Viru Intl for the best Santiago Arturo Merino Benitez - Santa Cruz de la Sierra Viru Viru Intl flight prices

You are more likely to see cheaper flights to Santa Cruz de la Sierra from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Cruz de la Sierra for around $418 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Cruz de la Sierra from Santiago for as low as $315 on momondo.

There is only 1 cabin class available to choose from on Santiago to Santa Cruz de la Sierra flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 9% on your flight if you consider stops on a Santiago to Santa Cruz de la Sierra flight.

As of August 2026, prices for Santiago to Santa Cruz de la Sierra flights are approximately 41% more expensive when compared to flights at the same time last year.

Historically, on average around 19% of flights between Santiago and Santa Cruz de la Sierra have experienced a delay on any given week. The average delay length over the past 12 months has been 48 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, BoA have had the least number of delays on this route over the last 12 months; with about 41% of their flights experiencing any sort of delay.