Cheap flights from Santiago to Cusco from $160

In general, November is the cheapest month to fly from Santiago to Cusco. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $250. If you aren’t able to travel to Cusco during the month of November, then flying in March is also cheap. Prices for this month can be found on momondo for an average of $264.

The cheapest day to depart from Santiago to Cusco is on a Monday when prices can be found for as low as $297. The most expensive day to fly to Cusco is Wednesday, with ticket prices averaging around $569.

According to our data, the cheapest time of day to fly to Cusco is in the afternoon. momondo users have found flights departing from Santiago to Cusco in the afternoon for as low as $392. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In contrast, the most expensive time of day to depart to Cusco is in the evening when prices are around $622.

Fly from Santiago Arturo Merino Benitez to Cusco Velazco Astete for the best Santiago Arturo Merino Benitez - Cusco Velazco Astete flight prices

You are more likely to see cheaper flights to Cusco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Cusco for around $281 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cusco from Santiago for as low as $246 on momondo.

You could potentially save up to 3% on your flight if you consider stops on a Santiago to Cusco flight.

As of May 2026, prices for Santiago to Cusco flights are approximately 33% more expensive when compared to flights at the same time last year.

Historically, on average around 11% of flights between Santiago and Cusco have experienced a delay on any given week. The average delay length over the past 12 months has been 140 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 11% of their flights experiencing any sort of delay.

As of May 2026, there are 1 flights per day flying from Santiago to Cusco. The most common time of day flights depart is 2:00PM, with 87% of flights taking off in the afternoon.

As of May 2026, 7 flights take off from Santiago and land in Cusco each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.