Cheap flights from San Francisco to Panama City from $207

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Panama City departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
12:42 am - 10:46 am
SFO
-
PTY
7h 04mnonstop
Copa Airlines Logo
6:27 pm - 11:20 pm
PTY
-
SFO
7h 53mnonstop
$637Copa Airlines
Tue, Feb 10 - Wed, Feb 18
Multiple Airlines Logo
11:10 pm - 10:30 am
SFO
-
PTY
8h 20m1 stop
Multiple Airlines Logo
3:50 pm - 9:56 am
PTY
-
SFO
21h 06m2 stops
$638Multiple Airlines
Tue, Feb 10 - Sat, Feb 21
Avianca Logo
1:35 am - 6:55 pm
SFO
-
PTY
14h 20m1 stop
Avianca Logo
2:55 pm - 12:00 pm
PTY
-
SFO
24h 05m2 stops
$644Avianca
Thu, Feb 12 - Wed, Feb 18
Multiple Airlines Logo
11:10 pm - 10:30 am
SFO
-
PTY
8h 20m1 stop
Multiple Airlines Logo
3:50 pm - 7:31 am
PTY
-
SFO
18h 41m2 stops
$645Multiple Airlines
Mon, Feb 9 - Fri, Feb 20
Multiple Airlines Logo
1:35 am - 6:55 pm
SFO
-
PTY
14h 20m1 stop
Multiple Airlines Logo
3:50 pm - 7:31 am
PTY
-
SFO
18h 41m2 stops
$646Multiple Airlines
Sat, Feb 7 - Fri, Feb 20
Multiple Airlines Logo
11:10 pm - 10:30 am
SFO
-
PTY
8h 20m1 stop
Multiple Airlines Logo
3:50 pm - 7:31 am
PTY
-
SFO
18h 41m2 stops
$648Multiple Airlines
Tue, Feb 10 - Fri, Feb 20
Multiple Airlines Logo
10:58 pm - 8:34 pm
SFO
-
PTY
18h 36m1 stop
Multiple Airlines Logo
3:50 pm - 11:20 pm
PTY
-
SFO
10h 30m1 stop
$651Multiple Airlines
Sat, Feb 14 - Thu, Feb 19
Copa Airlines Logo
12:42 am - 10:46 am
SFO
-
PTY
7h 04mnonstop
Copa Airlines Logo
6:27 pm - 11:20 pm
PTY
-
SFO
7h 53mnonstop
$652Copa Airlines
Wed, Feb 11 - Tue, Feb 17
Avianca Logo
2:35 am - 6:55 pm
SFO
-
PTY
14h 20m1 stop
Avianca Logo
3:20 am - 10:45 pm
PTY
-
SFO
21h 25m2 stops
$653Avianca
Thu, Mar 26 - Sat, Apr 4
Avianca Logo
1:35 am - 6:55 pm
SFO
-
PTY
14h 20m1 stop
Avianca Logo
7:50 pm - 12:00 pm
PTY
-
SFO
19h 10m1 stop
$654Avianca
Tue, Feb 10 - Wed, Feb 18

Avianca flights from San Francisco to Panama City

Our best Avianca deals on San Francisco to Panama City flight tickets
Avianca
Feb 12
SFO1:35 amSan Francisco
14h 20m
1 stop
PTY6:55 pmPanama City Tocumen Intl
Feb 18
PTY2:55 pmPanama City Tocumen Intl
24h 05m
2 stops
SFO12:00 pmSan Francisco
Avianca
Mar 26
SFO2:35 amSan Francisco
14h 20m
1 stop
PTY6:55 pmPanama City Tocumen Intl
Apr 4
PTY3:20 amPanama City Tocumen Intl
21h 25m
2 stops
SFO10:45 pmSan Francisco
Avianca
Feb 10
SFO1:35 amSan Francisco
14h 20m
1 stop
PTY6:55 pmPanama City Tocumen Intl
Feb 18
PTY7:50 pmPanama City Tocumen Intl
19h 10m
1 stop
SFO12:00 pmSan Francisco

American Airlines flights from San Francisco to Panama City

Our best American Airlines deals on San Francisco to Panama City flight tickets
American Airlines
Apr 1
SFO7:00 pmSan Francisco
17h 22m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Apr 8
PTY1:55 pmPanama City Tocumen Intl
21h 56m
2 stops
SFO9:51 amSan Francisco
American Airlines
Jan 30
SFO10:59 pmSan Francisco
13h 53m
1 stop
PTY3:52 pmPanama City Tocumen Intl
Feb 8
PTY4:50 pmPanama City Tocumen Intl
21h 13m
1 stop
SFO11:03 amSan Francisco
American Airlines
Jan 16
SFO10:59 pmSan Francisco
13h 53m
1 stop
PTY3:52 pmPanama City Tocumen Intl
Jan 25
PTY4:50 pmPanama City Tocumen Intl
21h 12m
1 stop
SFO11:02 amSan Francisco

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Tue 2/10

12:42 am-10:46 am

Nonstop7h 04m

Panama City Tocumen Intl

Wed 2/18

6:27 pm-11:20 pm

Nonstop7h 53m

$637

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Tue 2/10

11:10 pm-10:30 am

1 stop8h 20m

Panama City Tocumen Intl

Sat 2/21

3:50 pm-9:56 am

2 stops21h 06m

$638

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 2/12

1:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Wed 2/18

2:55 pm-12:00 pm

2 stops24h 05m

$644

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 2/9

11:10 pm-10:30 am

1 stop8h 20m

Panama City Tocumen Intl

Fri 2/20

3:50 pm-7:31 am

2 stops18h 41m

$645

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 2/7

1:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Fri 2/20

3:50 pm-7:31 am

2 stops18h 41m

$646

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Tue 2/10

11:10 pm-10:30 am

1 stop8h 20m

Panama City Tocumen Intl

Fri 2/20

3:50 pm-7:31 am

2 stops18h 41m

$648

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 2/14

10:58 pm-8:34 pm

1 stop18h 36m

Panama City Tocumen Intl

Thu 2/19

3:50 pm-11:20 pm

1 stop10h 30m

$651

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 2/11

12:42 am-10:46 am

Nonstop7h 04m

Panama City Tocumen Intl

Tue 2/17

6:27 pm-11:20 pm

Nonstop7h 53m

$652

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 3/26

2:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Sat 4/4

3:20 am-10:45 pm

2 stops21h 25m

$653

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Tue 2/10

1:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Wed 2/18

7:50 pm-12:00 pm

1 stop19h 10m

$654

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from San Francisco to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from San Francisco to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $533. If you’re not able to fly to Panama City in October, then August is your next best option. Flight prices from San Francisco to Panama City during August average around $584.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $645. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $761. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is at noon. Flights from San Francisco to Panama City during this time can be as low as $498. Try not to purchase tickets in the afternoon because they tend to be around $1,535. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Panama City Tocumen Intl flight route?

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $646 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from San Francisco for as low as $602 on momondo.

What cabin class options are available on San Francisco to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on San Francisco to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Francisco to Panama City flights?

You could potentially save up to 63% on your flight if you consider stops on a San Francisco to Panama City flight.

How have San Francisco to Panama City flight prices changed over time?

As of December 2025, prices for San Francisco to Panama City flights are approximately 41% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Panama City (SFO to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Panama City

Best Price Found

$295

Fastest flight time

6h 52m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from San Francisco in the past 72 hours is $295. The best round-trip flight deal from San Francisco to Panama City found on momondo in the last 72 hours is $646.
The fastest flight from San Francisco to Panama City takes 6h 52m
Direct flights go from San Francisco to Panama City every day.
There is 1 airport in Panama City. From San Francisco there are direct flights to Panama City Tocumen Intl (PTY).
  • How far is San Francisco to Panama City Tocumen Intl by plane?

    The distance between San Francisco and Panama City Tocumen Intl is about 3322.3 mi. A reasonable flight in good conditions will take 6h 52m.

  • When did momondo last update prices for flights from San Francisco Airport to Panama City Tocumen Intl Airport?

    Prices for flights from San Francisco Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from San Francisco Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Francisco to Panama City?

  • What is the most popular airline from San Francisco to Panama City?

Best airlines flying from San Francisco to Panama City

Compare and see reviews for airlines that fly from San Francisco to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $387Free CancellationRating
7.9
8,009 reviews
Search Delta flights
AviancaPriceFrom $427Free CancellationRating
6.6
2,490 reviews
Search Avianca flights
Copa AirlinesPriceFrom $503Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $533Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
American AirlinesPriceFrom $588Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
  • Copa Airlines Flights From San Francisco to Panama City

    Copa Airlines is one of the most popular airlines flying from San Francisco to Panama City, operating 14 flights/week on average for this route. A good Copa Airlines flight deal for San Francisco to Panama City starts from $503 round-trip, up to an average price of $657. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From San Francisco to Panama City

    $533 is the best United Airlines flight deal from San Francisco to Panama City found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $741, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 9,095 user reviews) flies into Panama City from San Francisco 14 times in an average week so prices can vary.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Panama City for you.

Can I find flights from San Francisco to Panama City with flexible booking policies on momondo?

Flights from San Francisco to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Sat 1/17
Sat 1/24

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