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Cheap flights from San Francisco to Panama City from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Panama City departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Avianca Logo
11:10 pm - 10:30 amSFO-PTY
8h 20m1 stop
Avianca Logo
5:50 pm - 12:00 pmPTY-SFO
21h 10m2 stops
$495Avianca
Find Deal
Wed, Jan 21 - Thu, Jan 22
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
$496Avianca
Find Deal
Wed, Jan 14 - Wed, Jan 21
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
9:45 am - 11:20 pmPTY-SFO
16h 35m2 stops
$499Avianca
Find Deal
Mon, Nov 24 - Sat, Dec 6
Avianca Logo
11:10 pm - 1:00 amSFO-PTY
22h 50m2 stops
Avianca Logo
2:55 am - 9:50 pmPTY-SFO
21h 55m2 stops
$501Avianca
Find Deal
Mon, Nov 24 - Fri, Dec 5
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
3:50 pm - 12:00 pmPTY-SFO
23h 10m1 stop
$503Avianca
Find Deal
Wed, Jan 14 - Wed, Jan 21
Avianca Logo
1:20 pm - 8:50 amSFO-PTY
16h 30m2 stops
Avianca Logo
5:50 pm - 12:00 pmPTY-SFO
21h 10m2 stops
$504Avianca
Find Deal
Wed, Jan 21 - Thu, Jan 22
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
$506Avianca
Find Deal
Sat, Nov 15 - Sun, Nov 23
Avianca Logo
1:35 am - 6:55 pmSFO-PTY
14h 20m1 stop
Avianca Logo
7:50 pm - 12:00 pmPTY-SFO
19h 10m1 stop
$508Avianca
Find Deal
Sat, Jan 10 - Sun, Jan 18
Multiple Airlines Logo
10:15 am - 9:20 amSFO-PTY
20h 05m3 stops
Multiple Airlines Logo
9:45 am - 11:20 pmPTY-SFO
16h 35m2 stops
$554Multiple Airlines
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Sat, Feb 7 - Tue, Feb 17
Multiple Airlines Logo
9:03 am - 5:20 amSFO-PTY
17h 17m1 stop
Multiple Airlines Logo
1:45 pm - 10:03 pmPTY-SFO
11h 18m1 stop
$558Multiple Airlines
Find Deal
Fri, Nov 28 - Fri, Dec 5

Avianca flights from San Francisco to Panama City

Our best Avianca deals on San Francisco to Panama City flight tickets
Avianca
Jan 21
SFO11:10 pmSan Francisco
8h 20m
1 stop
PTY10:30 amPanama City Tocumen Intl
Jan 22
PTY5:50 pmPanama City Tocumen Intl
21h 10m
2 stops
SFO12:00 pmSan Francisco
$495
Find similar
Avianca
Jan 14
SFO1:20 pmSan Francisco
18h 10m
1 stop
PTY10:30 amPanama City Tocumen Intl
Jan 21
PTY7:50 pmPanama City Tocumen Intl
19h 10m
1 stop
SFO12:00 pmSan Francisco
$496
Find similar
Avianca
Nov 24
SFO1:20 pmSan Francisco
18h 10m
1 stop
PTY10:30 amPanama City Tocumen Intl
Dec 6
PTY9:45 amPanama City Tocumen Intl
16h 35m
2 stops
SFO11:20 pmSan Francisco
$499
Find similar

Copa Airlines flights from San Francisco to Panama City

Our best Copa Airlines deals on San Francisco to Panama City flight tickets
Copa Airlines
Nov 9
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
Nov 16
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
$856
Find similar
Copa Airlines
Nov 9
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
Nov 16
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
$920
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/21

11:10 pm-10:30 am

1 stop8h 20m

Panama City Tocumen Intl

Thu 1/22

5:50 pm-12:00 pm

2 stops21h 10m

$495

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/14

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Wed 1/21

7:50 pm-12:00 pm

1 stop19h 10m

$496

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 11/24

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Sat 12/6

9:45 am-11:20 pm

2 stops16h 35m

$499

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 11/24

11:10 pm-1:00 am

2 stops22h 50m

Panama City Tocumen Intl

Fri 12/5

2:55 am-9:50 pm

2 stops21h 55m

$501

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/14

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Wed 1/21

3:50 pm-12:00 pm

1 stop23h 10m

$503

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/21

1:20 pm-8:50 am

2 stops16h 30m

Panama City Tocumen Intl

Thu 1/22

5:50 pm-12:00 pm

2 stops21h 10m

$504

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 11/15

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Sun 11/23

7:50 pm-12:00 pm

1 stop19h 10m

$506

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 1/10

1:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Sun 1/18

7:50 pm-12:00 pm

1 stop19h 10m

$508

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 2/7

10:15 am-9:20 am

3 stops20h 05m

Panama City Tocumen Intl

Tue 2/17

9:45 am-11:20 pm

2 stops16h 35m

$554

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Fri 11/28

9:03 am-5:20 am

1 stop17h 17m

Panama City Tocumen Intl

Fri 12/5

1:45 pm-10:03 pm

1 stop11h 18m

$558

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from San Francisco to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from San Francisco to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $576. If you’re not able to fly to Panama City in October, then August is your next best option. Flight prices from San Francisco to Panama City during August average around $580.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $633. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $739. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is at noon. Flights from San Francisco to Panama City during this time can be as low as $498. Try not to purchase tickets in the afternoon because they tend to be around $806. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Panama City Tocumen Intl flight route?

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $642 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from San Francisco for as low as $592 on momondo.

What cabin class options are available on San Francisco to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on San Francisco to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Francisco to Panama City flights?

You could potentially save up to 5% on your flight if you consider stops on a San Francisco to Panama City flight.

How have San Francisco to Panama City flight prices changed over time?

As of October 2025, prices for San Francisco to Panama City flights are approximately 62% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Panama City (SFO to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Panama City

Best Price Found

$233

Fastest flight time

6h 52m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from San Francisco in the past 72 hours is $233. The best round-trip flight deal from San Francisco to Panama City found on momondo in the last 72 hours is $561.
The fastest flight from San Francisco to Panama City takes 6h 52m
Direct flights go from San Francisco to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is San Francisco to Panama City Tocumen Intl by plane?

    The distance between San Francisco and Panama City Tocumen Intl is about 3322.3 mi. A reasonable flight in good conditions will take 8h 20m.

  • When did momondo last update prices for flights from San Francisco Airport to Panama City Tocumen Intl Airport?

    Prices for flights from San Francisco Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from San Francisco Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Francisco to Panama City?

  • What is the most popular airline from San Francisco to Panama City?

Best airlines flying from San Francisco to Panama City

Compare and see reviews for airlines that fly from San Francisco to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $387Free CancellationRating
7.9
7,993 reviews
Search Delta flights
AviancaPriceFrom $424Free CancellationRating
6.6
2,467 reviews
Search Avianca flights
Copa AirlinesPriceFrom $503Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $535Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $544Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights

  • Copa Airlines Flights From San Francisco to Panama City

    Copa Airlines is one of the most popular airlines flying from San Francisco to Panama City, operating 9 flights/week on average for this route. A good Copa Airlines flight deal for San Francisco to Panama City starts from $503 round-trip, up to an average price of $647. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From San Francisco to Panama City

    $535 is the best United Airlines flight deal from San Francisco to Panama City found on momondo over the last 72 hours. The average United Airlines ticket price found was closer to $717, however, with flight time and availability significantly affecting the price. United Airlines (7.4/10 from 8,998 user reviews) flies into Panama City from San Francisco 9 times in an average week so prices can vary.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Panama City for you.

Can I find flights from San Francisco to Panama City with flexible booking policies on momondo?

Flights from San Francisco to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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