Cheap flights from San Francisco to Panama City from $361

In general, April is the cheapest month to fly from San Francisco to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $668. If you’re not able to fly to Panama City in April, then February is your next best option. Flight prices from San Francisco to Panama City during February average around $686.

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $737. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $877. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from San Francisco to Panama City during this time can be as low as $792. Try not to purchase tickets in the afternoon because they tend to be around $1,283. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $772 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from San Francisco for as low as $666 on momondo.

There are 3 cabin classes available to choose from on San Francisco to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 61% on your flight if you consider stops on a San Francisco to Panama City flight.

As of October 2026, prices for San Francisco to Panama City flights are approximately 7% cheaper when compared to flights at the same time last year.

Aeromexico is the most popular carrier operating from San Francisco to Panama City Tocumen Intl

Copa Airlines, Avianca and United Airlines are the top three most popular airlines that fly to Panama City from San Francisco according to our data. Copa Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 7% of flights between San Francisco and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 105 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Tuesday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 6% of their flights experiencing any sort of delay.

San Salvador (SAL) was the most common stop: 71% of momondo users choosing 1-stop flights on this route connected there.

Flights via San Salvador (SAL) offer the lowest average round-trip price of $598.

Flights connecting via San Salvador (SAL) have the shortest average one-way travel time: 8h 42m.

San Salvador (SAL) has the shortest average layover time for this route: 1h 18m.

3 flights are operational daily from San Francisco to Panama City as of October 2026. The most popular departure time for this route is 1:00AM, with 100% of flights per day taking off in the morning.

21 flights are operational weekly from San Francisco to Panama City as of October 2026. The most popular departure day for this route is Mon, with 14% of flights per week taking off on this day.