Cheap flights from Panama City to Santo Domingo from $213

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Santo Domingo departing on 2/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m1 stop
Avianca Logo
12:20 pm - 4:55 pm
SDQ
-
PTY
5h 35m1 stop
$403Avianca
mar., feb. 10 - sáb., feb. 28
Avianca Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m1 stop
Avianca Logo
5:45 pm - 12:40 am
SDQ
-
PTY
7h 55m1 stop
$408Avianca
mar., feb. 17 - lun., feb. 23
Avianca Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m1 stop
Avianca Logo
5:45 pm - 8:50 am
SDQ
-
PTY
16h 05m1 stop
$410Avianca
jue., feb. 19 - vie., feb. 27
Avianca Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m1 stop
Avianca Logo
5:45 pm - 1:00 am
SDQ
-
PTY
8h 15m1 stop
$420Avianca
sáb., ene. 31 - dom., feb. 22
Avianca Logo
2:55 am - 11:25 am
PTY
-
SDQ
7h 30m1 stop
Avianca Logo
12:20 pm - 1:00 am
SDQ
-
PTY
13h 40m1 stop
$431Avianca
lun., ene. 12 - jue., ene. 22
Avianca Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m1 stop
Avianca Logo
5:45 pm - 8:50 am
SDQ
-
PTY
16h 05m1 stop
$452Avianca
mié., ene. 14 - vie., ene. 16
Copa Airlines Logo
7:10 pm - 10:39 pm
PTY
-
SDQ
2h 29mnonstop
Copa Airlines Logo
8:50 am - 10:30 am
SDQ
-
PTY
2h 40mnonstop
$453Copa Airlines
vie., feb. 20 - mié., feb. 25
Avianca Logo
2:55 am - 4:50 pm
PTY
-
SDQ
12h 55m1 stop
Avianca Logo
5:45 pm - 1:00 am
SDQ
-
PTY
8h 15m1 stop
$498Avianca
mié., ene. 14 - dom., ene. 25
Multiple Airlines Logo
9:45 am - 4:50 pm
PTY
-
SDQ
6h 05m1 stop
Multiple Airlines Logo
9:35 am - 9:10 pm
SDQ
-
PTY
12h 35m2 stops
$503Multiple Airlines
mar., ene. 20 - mié., may. 20
Multiple Airlines Logo
5:50 pm - 4:20 pm
PTY
-
SDQ
21h 30m2 stops
Multiple Airlines Logo
5:45 pm - 12:40 am
SDQ
-
PTY
7h 55m1 stop
$505Multiple Airlines
mar., feb. 24 - vie., feb. 27

Copa Airlines flights from Panama City to Santo Domingo

Our best Copa Airlines deals on Panama City to Santo Domingo flight tickets
Copa Airlines
Feb 20
PTY7:10 pmPanama City Tocumen Intl
2h 29m
SDQ10:39 pmSanto Domingo Las Americas
Feb 25
SDQ8:50 amSanto Domingo Las Americas
2h 40m
PTY10:30 amPanama City Tocumen Intl
$453
Copa Airlines
Jan 17
PTY7:26 pmPanama City Tocumen Intl
2h 29m
SDQ10:55 pmSanto Domingo Las Americas
Jan 21
SDQ8:50 amSanto Domingo Las Americas
2h 40m
PTY10:30 amPanama City Tocumen Intl
$538
Copa Airlines
Jan 10
PTY2:37 pmPanama City Tocumen Intl
2h 28m
SDQ6:05 pmSanto Domingo Las Americas
Jan 12
SDQ7:05 pmSanto Domingo Las Americas
2h 35m
PTY8:40 pmPanama City Tocumen Intl
$602

Avianca flights from Panama City to Santo Domingo

Our best Avianca deals on Panama City to Santo Domingo flight tickets
Avianca
Feb 10
PTY9:45 amPanama City Tocumen Intl
6h 05m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Feb 28
SDQ12:20 pmSanto Domingo Las Americas
5h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$403
Avianca
Feb 17
PTY9:45 amPanama City Tocumen Intl
6h 05m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Feb 23
SDQ5:45 pmSanto Domingo Las Americas
7h 55m
1 stop
PTY12:40 amPanama City Tocumen Intl
$408
Avianca
Feb 19
PTY2:55 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Feb 27
SDQ5:45 pmSanto Domingo Las Americas
16h 05m
1 stop
PTY8:50 amPanama City Tocumen Intl
$410

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 8, 2026.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mar. 2/10

9:45 am-4:50 pm

1 stop6h 05m

Santo Domingo Las Americas

sáb. 2/28

12:20 pm-4:55 pm

1 stop5h 35m

$403

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mar. 2/17

9:45 am-4:50 pm

1 stop6h 05m

Santo Domingo Las Americas

lun. 2/23

5:45 pm-12:40 am

1 stop7h 55m

$408

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

jue. 2/19

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

vie. 2/27

5:45 pm-8:50 am

1 stop16h 05m

$410

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

sáb. 1/31

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

dom. 2/22

5:45 pm-1:00 am

1 stop8h 15m

$420

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

lun. 1/12

2:55 am-11:25 am

1 stop7h 30m

Santo Domingo Las Americas

jue. 1/22

12:20 pm-1:00 am

1 stop13h 40m

$431

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mié. 1/14

9:45 am-4:50 pm

1 stop6h 05m

Santo Domingo Las Americas

vie. 1/16

5:45 pm-8:50 am

1 stop16h 05m

$452

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

vie. 2/20

7:10 pm-10:39 pm

Nonstop2h 29m

Santo Domingo Las Americas

mié. 2/25

8:50 am-10:30 am

Nonstop2h 40m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mié. 1/14

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

dom. 1/25

5:45 pm-1:00 am

1 stop8h 15m

$498

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mar. 1/20

9:45 am-4:50 pm

1 stop6h 05m

Santo Domingo Las Americas

mié. 5/20

9:35 am-9:10 pm

2 stops12h 35m

$503

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

mar. 2/24

5:50 pm-4:20 pm

2 stops21h 30m

Santo Domingo Las Americas

vie. 2/27

5:45 pm-12:40 am

1 stop7h 55m

$505

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Panama City to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until February to fly from Panama City, when ticket prices are also cheap, with an average price of $417.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Thursday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $428. The most expensive day to fly to Santo Domingo is Sunday, with ticket prices averaging around $532.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $409. Try not to purchase tickets in the evening because they tend to be around $468. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Panama City Tocumen Intl to Santo Domingo Las Americas flight route?

Fly from Panama City Tocumen Intl to Santo Domingo Las Americas for the best Panama City Tocumen Intl - Santo Domingo Las Americas flight prices

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $435 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from Panama City for as low as $396 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Santo Domingo Las Americas flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Santo Domingo Las Americas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Santo Domingo flights?

You could potentially save up to 49% on your flight if you consider stops on a Panama City to Santo Domingo flight.

How have Panama City to Santo Domingo flight prices changed over time?

As of January 2026, prices for Panama City to Santo Domingo flights are approximately 10% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Santo Domingo (PTY to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Santo Domingo

Best Price Found

$544

Fastest flight time

2h 22m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Santo Domingo

1 airport
The best one-way flight to Santo Domingo from Panama City in the past 72 hours is $544. The best round-trip flight deal from Panama City to Santo Domingo found on momondo in the last 72 hours is $409.
The fastest flight from Panama City to Santo Domingo takes 2h 22m
Direct flights go from Panama City to Santo Domingo on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in Santo Domingo. From Panama City there are direct flights to Santo Domingo Las Americas (SDQ).
  • How far is Panama City Tocumen Intl to Santo Domingo Las Americas by plane?

    The distance between Panama City Tocumen Intl and Santo Domingo Las Americas is about 918.3 mi. By plane, this route typically takes 2h 22m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Panama City to Santo Domingo?

  • What is the most popular airline from Panama City to Santo Domingo?

Best airlines flying from Panama City to Santo Domingo

Compare and see reviews for airlines that fly from Panama City to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $292Free CancellationRating
6.6
2,494 reviews
Search Avianca flights
Copa AirlinesPriceFrom $396Free CancellationRating
7.6
1,562 reviews
Search Copa Airlines flights
  • Copa Airlines Flights From Panama City to Santo Domingo

    Copa Airlines operates around 25 flights from Panama City to Santo Domingo every week. The average price of these flights found in the last 72 hours has been $452, but momondo users have found Copa Airlines deals from Panama City to Santo Domingo from as low as $396 round-trip. Copa Airlines has been scored 7.6/10 in 1,562 reviews.

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Santo Domingo with flexible booking policies on momondo?

Flights from Panama City to Santo Domingo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Santo Domingo?

Once you have performed a search for Panama City to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
sáb. 2/7
sáb. 2/14

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