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Cheap flights from Panama City to Santo Domingo from $246

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Santo Domingo departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to Santo Domingo

Cheap round-trip flights

Copa Airlines Logo
6:55 pm - 10:26 pmPTY-SDQ
2h 31mnonstop
Copa Airlines Logo
11:56 am - 1:29 pmSDQ-PTY
2h 33mnonstop
$450Copa Airlines
Find Deal
Sat, Sep 13 - Sat, Sep 20
Avianca Logo
2:55 am - 4:50 pmPTY-SDQ
12h 55m1 stop
Avianca Logo
5:45 pm - 8:50 amSDQ-PTY
16h 05m1 stop
$451Avianca
Find Deal
Thu, Oct 30 - Wed, Nov 5
Avianca Logo
2:55 am - 4:50 pmPTY-SDQ
12h 55m1 stop
Avianca Logo
5:45 pm - 12:40 amSDQ-PTY
7h 55m1 stop
$452Avianca
Find Deal
Fri, Oct 31 - Mon, Nov 10
Copa Airlines Logo
9:42 am - 1:12 pmPTY-SDQ
2h 30mnonstop
Copa Airlines Logo
6:39 pm - 8:14 pmSDQ-PTY
2h 35mnonstop
$453Copa Airlines
Find Deal
Thu, Nov 13 - Tue, Nov 18
Copa Airlines Logo
7:28 am - 10:58 amPTY-SDQ
2h 30mnonstop
Copa Airlines Logo
8:55 am - 10:30 amSDQ-PTY
2h 35mnonstop
$467Copa Airlines
Find Deal
Fri, Oct 31 - Tue, Nov 11
Copa Airlines Logo
10:55 pm - 2:26 amPTY-SDQ
2h 31mnonstop
Copa Airlines Logo
8:55 am - 10:30 amSDQ-PTY
2h 35mnonstop
$469Copa Airlines
Find Deal
Sat, Nov 1 - Mon, Nov 10
Copa Airlines Logo
12:44 pm - 4:17 pmPTY-SDQ
2h 33mnonstop
Copa Airlines Logo
2:11 pm - 3:47 pmSDQ-PTY
2h 36mnonstop
$478Copa Airlines
Find Deal
Thu, Sep 25 - Fri, Jan 2
Copa Airlines Logo
7:28 am - 10:58 amPTY-SDQ
2h 30mnonstop
Copa Airlines Logo
2:15 pm - 3:50 pmSDQ-PTY
2h 35mnonstop
$483Copa Airlines
Find Deal
Fri, Oct 31 - Wed, Nov 5
Copa Airlines Logo
12:44 pm - 4:15 pmPTY-SDQ
2h 31mnonstop
Copa Airlines Logo
2:15 pm - 3:50 pmSDQ-PTY
2h 35mnonstop
$485Copa Airlines
Find Deal
Sat, Nov 1 - Mon, Nov 10
Logo
10:05 pm - 10:50 amPTY-SDQ
11h 45m1 stop
Logo
5:05 pm - 9:10 pmSDQ-PTY
29h 05m2 stops
$522
Find Deal
Sun, Sep 14 - Sun, Sep 21

Copa Airlines flights from Panama City to Santo Domingo

Our best Copa Airlines deals on Panama City to Santo Domingo flight tickets
Copa Airlines
Sep 13
PTY6:55 pmPanama City Tocumen Intl
2h 31m
SDQ10:26 pmSanto Domingo Las Americas
Sep 20
SDQ11:56 amSanto Domingo Las Americas
2h 33m
PTY1:29 pmPanama City Tocumen Intl
$450
Find similar
Copa Airlines
Nov 13
PTY9:42 amPanama City Tocumen Intl
2h 30m
SDQ1:12 pmSanto Domingo Las Americas
Nov 18
SDQ6:39 pmSanto Domingo Las Americas
2h 35m
PTY8:14 pmPanama City Tocumen Intl
$453
Find similar
Copa Airlines
Oct 31
PTY7:28 amPanama City Tocumen Intl
2h 30m
SDQ10:58 amSanto Domingo Las Americas
Nov 11
SDQ8:55 amSanto Domingo Las Americas
2h 35m
PTY10:30 amPanama City Tocumen Intl
$467
Find similar

Avianca flights from Panama City to Santo Domingo

Our best Avianca deals on Panama City to Santo Domingo flight tickets
Avianca
Aug 20
PTY3:20 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ5:15 pmSanto Domingo Las Americas
Aug 24
SDQ6:10 pmSanto Domingo Las Americas
7h 00m
1 stop
PTY12:10 amPanama City Tocumen Intl
$450
Find similar
Avianca
Oct 30
PTY2:55 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Nov 5
SDQ5:45 pmSanto Domingo Las Americas
16h 05m
1 stop
PTY8:50 amPanama City Tocumen Intl
$451
Find similar
Avianca
Oct 31
PTY2:55 amPanama City Tocumen Intl
12h 55m
1 stop
SDQ4:50 pmSanto Domingo Las Americas
Nov 10
SDQ5:45 pmSanto Domingo Las Americas
7h 55m
1 stop
PTY12:40 amPanama City Tocumen Intl
$452
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 9/13

6:55 pm-10:26 pm

Nonstop2h 31m

Santo Domingo Las Americas

Sat 9/20

11:56 am-1:29 pm

Nonstop2h 33m

$450

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 10/30

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

Wed 11/5

5:45 pm-8:50 am

1 stop16h 05m

$451

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 10/31

2:55 am-4:50 pm

1 stop12h 55m

Santo Domingo Las Americas

Mon 11/10

5:45 pm-12:40 am

1 stop7h 55m

$452

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 11/13

9:42 am-1:12 pm

Nonstop2h 30m

Santo Domingo Las Americas

Tue 11/18

6:39 pm-8:14 pm

Nonstop2h 35m

$453

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 10/31

7:28 am-10:58 am

Nonstop2h 30m

Santo Domingo Las Americas

Tue 11/11

8:55 am-10:30 am

Nonstop2h 35m

$467

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 11/1

10:55 pm-2:26 am

Nonstop2h 31m

Santo Domingo Las Americas

Mon 11/10

8:55 am-10:30 am

Nonstop2h 35m

$469

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Thu 9/25

12:44 pm-4:17 pm

Nonstop2h 33m

Santo Domingo Las Americas

Fri 1/2

2:11 pm-3:47 pm

Nonstop2h 36m

$478

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Fri 10/31

7:28 am-10:58 am

Nonstop2h 30m

Santo Domingo Las Americas

Wed 11/5

2:15 pm-3:50 pm

Nonstop2h 35m

$483

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sat 11/1

12:44 pm-4:15 pm

Nonstop2h 31m

Santo Domingo Las Americas

Mon 11/10

2:15 pm-3:50 pm

Nonstop2h 35m

$485

Panama CitySanto Domingo

PTY - SDQ

PTYSDQ

Panama City Tocumen Intl

Sun 9/14

10:05 pm-10:50 am

1 stop11h 45m

Santo Domingo Las Americas

Sun 9/21

5:05 pm-9:10 pm

2 stops29h 05m

$522

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Panama City to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until October to fly from Panama City, when ticket prices are also cheap, with an average price of $414.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Thursday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $417. The most expensive day to fly to Santo Domingo is Monday, with ticket prices averaging around $471.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the evening when flights can be purchased for as low as $417. Try not to purchase tickets in the morning because they tend to be around $433. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Panama City Tocumen Intl to Santo Domingo Las Americas flight route?

Fly from Panama City Tocumen Intl to Santo Domingo Las Americas for the best Panama City Tocumen Intl - Santo Domingo Las Americas flight prices

How far in advance should I book a flight to Santo Domingo?

You are more likely to see cheaper flights to Santo Domingo from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from Panama City for as low as $394 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Santo Domingo Las Americas flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Santo Domingo Las Americas flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Panama City to Santo Domingo flight prices changed over time?

As of August 2025, prices for Panama City to Santo Domingo flights are approximately 88% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Santo Domingo (PTY to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Santo Domingo

Best Price Found

$246

Fastest flight time

2h 23m

Direct flights

Tue, Wed, Fri, Sat and Sun

Airports in Santo Domingo

1 airport
The best one-way flight to Santo Domingo from Panama City in the past 72 hours is $246. The best round-trip flight deal from Panama City to Santo Domingo found on momondo in the last 72 hours is $450.
The fastest flight from Panama City to Santo Domingo takes 2h 23m
Direct flights go from Panama City to Santo Domingo on Tuesday, Wednesday, Friday, Saturday and Sunday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near Santo Domingo: Santo Domingo Las Americas (SDQ)
Search flight deals

  • How far is Panama City Tocumen Intl to Santo Domingo Las Americas by plane?

    The distance between Panama City Tocumen Intl and Santo Domingo Las Americas is about 918.3 mi. By plane, this route typically takes 2h 22m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Panama City to Santo Domingo?

  • What is the most popular airline from Panama City to Santo Domingo?

Best airlines flying from Panama City to Santo Domingo

Compare and see reviews for airlines that fly from Panama City to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $292Free CancellationRating
6.7
2,407 reviews
Search Avianca flights
Copa AirlinesPriceFrom $393Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to Santo Domingo

    Copa Airlines operates around 26 flights from Panama City to Santo Domingo every week. The average price of these flights found in the last 72 hours has been $428, but momondo users have found Copa Airlines deals from Panama City to Santo Domingo from as low as $393 round-trip. Copa Airlines has been scored 7.5/10 in 1,510 reviews.

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Santo Domingo?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Santo Domingo. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Santo Domingo with flexible booking policies on momondo?

Flights from Panama City to Santo Domingo with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Santo Domingo?

Once you have performed a search for Panama City to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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