Cheap flights from Panama City to Santo Domingo from $366

If you don’t want to visit Santo Domingo in January, then you should wait until February to fly from Panama City, when ticket prices are also cheap, with an average price of $463.

Our data shows that Friday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $528. The most expensive day to fly to Santo Domingo is Tuesday, with ticket prices averaging around $549.

The cheapest time of day to fly to Santo Domingo is at noon when flights can be purchased for as low as $431. Try not to purchase tickets in the evening because they tend to be around $549. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Panama City Tocumen Intl to Santo Domingo Las Americas for the best Panama City Tocumen Intl - Santo Domingo Las Americas flight prices

You are more likely to see cheaper flights to Santo Domingo from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $506 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from Panama City for as low as $471 on momondo.

There are 3 cabin classes available to choose from on Panama City to Santo Domingo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 51% on your flight if you consider stops on a Panama City to Santo Domingo flight.

As of October 2026, prices for Panama City to Santo Domingo flights are approximately 30% more expensive when compared to flights at the same time last year.

Historically, on average around 5% of flights between Panama City and Santo Domingo have experienced a delay on any given week. The average delay length over the past 12 months has been 110 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 5% of their flights experiencing any sort of delay.

As of October 2026, 5 flights take off from Panama City and land in Santo Domingo each day. The most common flight departure time for this route is 7:00PM, with 53% of daily flights taking off in the evening.

The number of flights available between Panama City and Santo Domingo is 37 per week as of October 2026. The most frequent departure day is Sat, with 27% of weekly flights leaving on this day.