Cheap flights from North Carolina to Panama City from $205

In general, April is the cheapest month to fly from North Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $541. If you’re not able to fly to Panama City in April, then February is your next best option. Flight prices from North Carolina to Panama City during February average around $584.

Our data shows that Saturday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $430. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $961. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Fly from Raleigh-Durham to Panama City Tocumen Intl for the best North Carolina - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $668 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from North Carolina for as low as $528 on momondo.

There are 3 cabin classes available to choose from on North Carolina to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 68% on your flight if you consider stops on a North Carolina to Panama City flight.

Delta, United Airlines, and American Airlines are the most popular carriers operating from North Carolina to Panama City Tocumen Intl

Copa Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Panama City from North Carolina according to our data. Copa Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

The number of flights available between North Carolina and Panama City is 1 per day as of November 2026. The most frequent departure time is 4:00PM, with 100% of daily flights leaving in the afternoon.

8 flights are operational weekly from North Carolina to Panama City as of November 2026. The most popular departure day for this route is Mon, with 25% of flights per week taking off on this day.