What is the cheapest airline that flies from North Carolina to Panama?

United Airlines, American Airlines, and Delta are the most popular carriers operating from North Carolina to Panama

How many flights depart from North Carolina to Panama on average per week?

The number of flights available between North Carolina and Panama is 4 per week as of August 2025. The most frequent departure day is Mon, with 25% of weekly flights leaving on this day.

How long is the flight from North Carolina to Panama?

Flight times from North Carolina to Panama vary, but if you’re flying out of Raleigh and flying into Panama City (one of the most popular routes), then the duration is 4h 24m on average. Another popular route from North Carolina to Panama is flying from Asheville to Panama City, which will take roughly 6h 07m. Keep in mind that layovers or delays could extend your travel time.

What airlines fly to Panama?

Copa Airlines, American Airlines and Delta are the top three most popular airlines that fly to Panama from North Carolina according to our data. Copa Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from North Carolina to Panama?

Prices for flights from North Carolina to Panama refresh daily.

How many operators does momondo search for flights from North Carolina to Panama?

There are 4 operators available for flights from North Carolina to Panama as of August 2025.

How old do you have to be to fly from North Carolina to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from North Carolina to Panama.

What documentation or ID do you need to fly to Panama?

The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$163 Cheap Flights from North Carolina to Panama in 2025

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Find the cheapest flights from North Carolina to Panama

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

6:15 am - 9:10 pmCLT-PTY

15h 55m2 stops

3:25 am - 9:59 pmPTY-CLT

17h 34m2 stops

$386

Find Deal

Wed, Oct 8 - Fri, Oct 10

4:19 pm - 7:46 pmRDU-PTY

4h 27mnonstop

8:57 am - 2:27 pmPTY-RDU

4h 30mnonstop

$389Copa Airlines

Find Deal

Wed, Oct 15 - Wed, Oct 22

9:00 pm - 2:30 pmRDU-PTY

18h 30m2 stops

3:31 pm - 9:29 amPTY-RDU

16h 58m2 stops

$399American Airlines

Find Deal

Sun, Aug 31 - Sun, Sep 7

6:20 am - 12:55 pmRDU-PTY

7h 35m1 stop

2:10 pm - 10:38 pmPTY-RDU

7h 28m1 stop

$403Delta

Find Deal

Sun, Sep 14 - Tue, Sep 16

7:51 pm - 2:03 pmRDU-PTY

19h 12m2 stops

3:15 pm - 11:56 pmPTY-RDU

7h 41m1 stop

$408American Airlines

Find Deal

Tue, Oct 14 - Mon, Oct 20

10:50 am - 12:55 pmRDU-PTY

27h 05m1 stop

2:10 pm - 10:38 pmPTY-RDU

7h 28m1 stop

$410Delta

Find Deal

Sat, Sep 20 - Thu, Sep 25

6:30 am - 2:14 pmRDU-PTY

8h 44m1 stop

3:30 pm - 9:52 pmPTY-RDU

29h 22m1 stop

$412United Airlines

Find Deal

Mon, Sep 8 - Mon, Sep 15

6:30 am - 2:14 pmRDU-PTY

8h 44m1 stop

3:30 pm - 10:14 pmPTY-RDU

29h 44m1 stop

$414United Airlines

Find Deal

Fri, Oct 3 - Sun, Oct 5

5:45 am - 12:35 pmTYS-PTY

31h 50m3 stops

8:10 pm - 10:28 amPTY-TYS

13h 18m2 stops

$853Avianca

Find Deal

Sat, Sep 20 - Mon, Sep 22

5:45 am - 10:25 amTYS-PTY

29h 40m2 stops

1:30 pm - 10:28 amPTY-TYS

19h 58m3 stops

$858Avianca

Find Deal

Wed, Sep 17 - Mon, Sep 22

American Airlines flights from North Carolina to Panama

Our best American Airlines deals on North Carolina to Panama flight tickets

American Airlines

Aug 31

RDU9:00 pmRaleigh-Durham

18h 30m

2 stops

PTY2:30 pmPanama City Tocumen Intl

Sep 7

PTY3:31 pmPanama City Tocumen Intl

16h 58m

2 stops

RDU9:29 amRaleigh-Durham

$399

Find similar

American Airlines

Oct 14

RDU7:51 pmRaleigh-Durham

19h 12m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 20

PTY3:15 pmPanama City Tocumen Intl

7h 41m

1 stop

RDU11:56 pmRaleigh-Durham

$408

Find similar

American Airlines

Oct 15

RDU7:40 pmRaleigh-Durham

19h 23m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 19

PTY3:15 pmPanama City Tocumen Intl

19h 46m

2 stops

RDU12:01 pmRaleigh-Durham

$413

Find similar

Copa Airlines flights from North Carolina to Panama

Our best Copa Airlines deals on North Carolina to Panama flight tickets

Copa Airlines

Aug 31

RDU4:22 pmRaleigh-Durham

4h 24m

PTY7:46 pmPanama City Tocumen Intl

Sep 7

PTY8:57 amPanama City Tocumen Intl

4h 30m

RDU2:27 pmRaleigh-Durham

$389

Find similar

Copa Airlines

Nov 5

RDU3:14 pmRaleigh-Durham

4h 32m

PTY7:46 pmPanama City Tocumen Intl

Nov 16

PTY8:57 amPanama City Tocumen Intl

4h 30m

RDU1:27 pmRaleigh-Durham

$404

Find similar

Copa Airlines

Sep 14

RDU4:21 pmRaleigh-Durham

4h 25m

PTY7:46 pmPanama City Tocumen Intl

Sep 21

PTY8:57 amPanama City Tocumen Intl

4h 30m

RDU2:27 pmRaleigh-Durham

$441

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 10/8

6:15 am-9:10 pm

2 stops15h 55m

Panama City Tocumen Intl

Fri 10/10

3:25 am-9:59 pm

2 stops17h 34m

$386

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 10/15

4:19 pm-7:46 pm

Nonstop4h 27m

Panama City Tocumen Intl

Wed 10/22

8:57 am-2:27 pm

Nonstop4h 30m

$389

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 8/31

9:00 pm-2:30 pm

2 stops18h 30m

Panama City Tocumen Intl

Sun 9/7

3:31 pm-9:29 am

2 stops16h 58m

$399

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 9/14

6:20 am-12:55 pm

1 stop7h 35m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-10:38 pm

1 stop7h 28m

$403

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Tue 10/14

7:51 pm-2:03 pm

2 stops19h 12m

Panama City Tocumen Intl

Mon 10/20

3:15 pm-11:56 pm

1 stop7h 41m

$408

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sat 9/20

10:50 am-12:55 pm

1 stop27h 05m

Panama City Tocumen Intl

Thu 9/25

2:10 pm-10:38 pm

1 stop7h 28m

$410

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Mon 9/8

6:30 am-2:14 pm

1 stop8h 44m

Panama City Tocumen Intl

Mon 9/15

3:30 pm-9:52 pm

1 stop29h 22m

$412

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 10/3

6:30 am-2:14 pm

1 stop8h 44m

Panama City Tocumen Intl

Sun 10/5

3:30 pm-10:14 pm

1 stop29h 44m

$414

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 9/20

5:45 am-12:35 pm

3 stops31h 50m

Panama City Tocumen Intl

Mon 9/22

8:10 pm-10:28 am

2 stops13h 18m

$853

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 9/17

5:45 am-10:25 am

2 stops29h 40m

Panama City Tocumen Intl

Mon 9/22

1:30 pm-10:28 am

3 stops19h 58m

$858

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from North Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from North Carolina, with most prices found around $503. If you don’t want to visit Panama in September, then you should wait until May to fly from North Carolina, when ticket prices are also cheap, with an average price of $507.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from North Carolina. The lowest ticket price found for a Tuesday departure recently was $321. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from North Carolina to Panama for around $546.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from North Carolina to Panama when you can find flight prices for as low as $412. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $553 per ticket.

What is the cheapest North Carolina to Panama flight route?

Fly from Raleigh-Durham to Panama City Tocumen Intl for the best North Carolina - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $564 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from North Carolina for as low as $462 on momondo.

What cabin class options are available on North Carolina to Panama flights?

There are 3 cabin classes available to choose from on North Carolina to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on North Carolina to Panama flights?

You could potentially save up to 68% on your flight if you consider stops on a North Carolina to Panama flight.

Cheap North Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Panama

Best Price Found	$200
Fastest flight time	4h 25m
Direct flights	Mon, Tue, Thu, Sat and Sun
Airports in Panama	1 airport

The best one-way flight to Panama from North Carolina in the past 72 hours is $200. The best round-trip flight deal from North Carolina to Panama found on momondo in the last 72 hours is $307.

The fastest flight from North Carolina to Panama takes 4h 25m

Direct flights go from North Carolina to Panama on Monday, Tuesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.

There is 1 airport near Panama: Panama City Tocumen Intl (PTY)

Search flight deals

When did momondo last update prices for flights from North Carolina to Panama?
Prices for flights from North Carolina to Panama refresh daily.
How many operators does momondo search for flights from North Carolina to Panama?
There are 4 operators available for flights from North Carolina to Panama as of August 2025.
How old do you have to be to fly from North Carolina to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from North Carolina to Panama.
What documentation or ID do you need to fly to Panama?
The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from North Carolina to Panama?
momondo data reveals that the most frequently booked plane model on the route from North Carolina to Panama is Boeing 737-800, representing 75.68% of all bookings. The subsequent popular models are Airbus A320-100/200 at 4.50%, Boeing 787-9 Dreamliner at 3.60%, and Airbus A320neo at 2.70%.

Best airlines flying from North Carolina to Panama

Compare and see reviews for airlines that fly from North Carolina to Panama with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $249	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
Copa Airlines	PriceFrom $282	Free Cancellation	Rating 7.5 1,510 reviews	Search Copa Airlines flights
Delta	PriceFrom $302	Free Cancellation	Rating 7.9 7,982 reviews	Search Delta flights
United Airlines	PriceFrom $351	Free Cancellation	Rating 7.4 8,928 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from North Carolina to Panama for you.

Can I find flights from North Carolina to Panama with flexible booking policies on momondo?

Flights from North Carolina to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from North Carolina to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from North Carolina.

I’m not ready to book a flight from North Carolina to Panama right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of North Carolina to Panama flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Panama trip

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Popular cities in Panama

Flights to Panama Cityfrom $269

Flights to Bocas del Torofrom $691

Flights to Davidfrom $359

Flights to Changuinola

Cheap flights from North Carolina to Panama from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Panama departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Filter for what you want

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Find the cheapest flights from North Carolina to Panama

Cheap round-trip flights

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Cheap last minute flights

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American Airlines flights from North Carolina to Panama

Our best American Airlines deals on North Carolina to Panama flight tickets

Copa Airlines flights from North Carolina to Panama

Our best Copa Airlines deals on North Carolina to Panama flight tickets

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How to get the cheapest flight ticket from North Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

What is the cheapest North Carolina to Panama flight route?

Fly from Raleigh-Durham to Panama City Tocumen Intl for the best North Carolina - Panama flight prices

How far in advance should I book a flight to Panama?

What cabin class options are available on North Carolina to Panama flights?

There are 3 cabin classes available to choose from on North Carolina to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on North Carolina to Panama flights?

You could potentially save up to 68% on your flight if you consider stops on a North Carolina to Panama flight.

What is the cheapest airline that flies from North Carolina to Panama?

United Airlines, American Airlines, and Delta are the most popular carriers operating from North Carolina to Panama

What airlines fly to Panama?

How many flights depart from North Carolina to Panama on average per week?

The number of flights available between North Carolina and Panama is 4 per week as of August 2025. The most frequent departure day is Mon, with 25% of weekly flights leaving on this day.

How long is the flight from North Carolina to Panama?

Cheap North Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Panama

Best Price Found

Fastest flight time

Direct flights

Airports in Panama

When did momondo last update prices for flights from North Carolina to Panama?

How many operators does momondo search for flights from North Carolina to Panama?

How old do you have to be to fly from North Carolina to Panama?

What documentation or ID do you need to fly to Panama?

What is the most popular plane model from North Carolina to Panama?

Best airlines flying from North Carolina to Panama

Compare and see reviews for airlines that fly from North Carolina to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Panama?

Can I find flights from North Carolina to Panama with flexible booking policies on momondo?

How can momondo help me find flights from North Carolina to Panama?

I’m not ready to book a flight from North Carolina to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo