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Cheap flights from North Carolina to Panama from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Panama departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from North Carolina to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:20 am - 1:55 pm
ORF
-
PTY
8h 35m1 stop
Delta Logo
2:20 pm - 12:30 am
PTY
-
ORF
9h 10m1 stop
$404Delta
Mon, Feb 9 - Thu, Apr 23
American Airlines Logo
5:00 pm - 1:27 pm
ORF
-
PTY
20h 27m2 stops
American Airlines Logo
2:27 pm - 1:08 pm
PTY
-
ORF
22h 41m2 stops
$408American Airlines
Thu, Jan 29 - Tue, Feb 3
American Airlines Logo
7:28 pm - 3:38 pm
ORF
-
PTY
20h 10m1 stop
American Airlines Logo
2:27 pm - 2:51 pm
PTY
-
ORF
24h 24m2 stops
$417American Airlines
Thu, Jan 29 - Tue, Feb 3
American Airlines Logo
5:54 pm - 1:27 pm
ORF
-
PTY
19h 33m2 stops
American Airlines Logo
4:05 pm - 9:59 am
PTY
-
ORF
17h 54m2 stops
$426American Airlines
Thu, Jan 29 - Sat, Feb 14
United Airlines Logo
4:12 pm - 2:45 pm
ORF
-
PTY
22h 33m2 stops
United Airlines Logo
4:41 pm - 3:27 pm
PTY
-
ORF
22h 46m2 stops
$428United Airlines
Mon, Jan 12 - Sat, Jan 17
United Airlines Logo
6:00 am - 2:45 pm
ORF
-
PTY
8h 45m1 stop
United Airlines Logo
4:41 pm - 2:03 pm
PTY
-
ORF
21h 22m2 stops
$429United Airlines
Tue, Feb 3 - Wed, Feb 18
American Airlines Logo
7:28 pm - 1:27 pm
ORF
-
PTY
17h 59m1 stop
American Airlines Logo
4:05 pm - 1:10 pm
PTY
-
ORF
21h 05m2 stops
$435American Airlines
Thu, Jan 29 - Sat, Feb 14
Delta Logo
6:00 am - 12:55 pm
ILM
-
PTY
7h 55m1 stop
Delta Logo
2:20 pm - 11:59 pm
PTY
-
ILM
8h 39m1 stop
$436Delta
Tue, Apr 28 - Tue, May 5
Copa Airlines Logo
3:12 pm - 7:46 pm
RDU
-
PTY
4h 34mnonstop
Copa Airlines Logo
8:57 am - 1:14 pm
PTY
-
RDU
4h 17mnonstop
$441Copa Airlines
Wed, Feb 4 - Wed, Feb 18
Copa Airlines Logo
4:14 pm - 7:46 pm
RDU
-
PTY
4h 32mnonstop
Copa Airlines Logo
8:57 am - 2:23 pm
PTY
-
RDU
4h 26mnonstop
$471Copa Airlines
Sun, Mar 22 - Sun, Mar 29

Delta flights from North Carolina to Panama

Our best Delta deals on North Carolina to Panama flight tickets
Delta
Feb 9
ORF5:20 amNorfolk
8h 35m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Apr 23
PTY2:20 pmPanama City Tocumen Intl
9h 10m
1 stop
ORF12:30 amNorfolk
$404
Find similar
Delta
Apr 28
ILM6:00 amWilmington New Hanover County
7h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
May 5
PTY2:20 pmPanama City Tocumen Intl
8h 39m
1 stop
ILM11:59 pmWilmington New Hanover County
$436
Find similar
Delta
Feb 1
MYR6:54 pmMyrtle Beach Intl
19h 01m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Mar 4
PTY3:15 pmPanama City Tocumen Intl
18h 30m
1 stop
MYR9:45 amMyrtle Beach Intl
$490
Find similar

American Airlines flights from North Carolina to Panama

Our best American Airlines deals on North Carolina to Panama flight tickets
American Airlines
Jan 29
ORF5:00 pmNorfolk
20h 27m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Feb 3
PTY2:27 pmPanama City Tocumen Intl
22h 41m
2 stops
ORF1:08 pmNorfolk
$408
Find similar
American Airlines
Jan 29
ORF7:28 pmNorfolk
20h 10m
1 stop
PTY3:38 pmPanama City Tocumen Intl
Feb 3
PTY2:27 pmPanama City Tocumen Intl
24h 24m
2 stops
ORF2:51 pmNorfolk
$417
Find similar
American Airlines
Jan 29
ORF5:54 pmNorfolk
19h 33m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Feb 14
PTY4:05 pmPanama City Tocumen Intl
17h 54m
2 stops
ORF9:59 amNorfolk
$426
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Mon 2/9

5:20 am-1:55 pm

1 stop8h 35m

Panama City Tocumen Intl

Thu 4/23

2:20 pm-12:30 am

1 stop9h 10m

$404

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 1/29

5:00 pm-1:27 pm

2 stops20h 27m

Panama City Tocumen Intl

Tue 2/3

2:27 pm-1:08 pm

2 stops22h 41m

$408

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 1/29

7:28 pm-3:38 pm

1 stop20h 10m

Panama City Tocumen Intl

Tue 2/3

2:27 pm-2:51 pm

2 stops24h 24m

$417

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 1/29

5:54 pm-1:27 pm

2 stops19h 33m

Panama City Tocumen Intl

Sat 2/14

4:05 pm-9:59 am

2 stops17h 54m

$426

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Mon 1/12

4:12 pm-2:45 pm

2 stops22h 33m

Panama City Tocumen Intl

Sat 1/17

4:41 pm-3:27 pm

2 stops22h 46m

$428

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Tue 2/3

6:00 am-2:45 pm

1 stop8h 45m

Panama City Tocumen Intl

Wed 2/18

4:41 pm-2:03 pm

2 stops21h 22m

$429

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 1/29

7:28 pm-1:27 pm

1 stop17h 59m

Panama City Tocumen Intl

Sat 2/14

4:05 pm-1:10 pm

2 stops21h 05m

$435

WilmingtonPanama City

ILM - PTY

ILMPTY

Wilmington New Hanover County

Tue 4/28

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-11:59 pm

1 stop8h 39m

$436

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 2/4

3:12 pm-7:46 pm

Nonstop4h 34m

Panama City Tocumen Intl

Wed 2/18

8:57 am-1:14 pm

Nonstop4h 17m

$441

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 3/22

4:14 pm-7:46 pm

Nonstop4h 32m

Panama City Tocumen Intl

Sun 3/29

8:57 am-2:23 pm

Nonstop4h 26m

$471

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from North Carolina to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of October is, on average, the cheapest month to fly to Panama from North Carolina, with most prices found around $402. If you don’t want to visit Panama in October, then you should wait until September to fly from North Carolina, when ticket prices are also cheap, with an average price of $418.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from North Carolina. The lowest ticket price found for a Tuesday departure recently was $346. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from North Carolina to Panama for around $778.

What is the cheapest time of day to depart on your flight to Panama?

At noon is the cheapest time of day to fly from North Carolina to Panama when you can find flight prices for as low as $413. Flying to Panama at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $553 per ticket.

What is the cheapest North Carolina to Panama flight route?

Fly from Raleigh-Durham to Panama City Tocumen Intl for the best North Carolina - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $507 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from North Carolina for as low as $408 on momondo.

What cabin class options are available on North Carolina to Panama flights?

There are 3 cabin classes available to choose from on North Carolina to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on North Carolina to Panama flights?

You could potentially save up to 70% on your flight if you consider stops on a North Carolina to Panama flight.

Cheap North Carolina to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Panama

Best Price Found

$301

Fastest flight time

4h 26m

Direct flights

Mon, Tue, Thu, Sat and Sun

Airports in Panama

21 airports
The best one-way flight to Panama from North Carolina in the past 72 hours is $301. The best round-trip flight deal from North Carolina to Panama found on momondo in the last 72 hours is $350.
The fastest flight from North Carolina to Panama takes 4h 26m
Direct flights go from North Carolina to Panama on Monday, Tuesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.
There are 21 airports in Panama. From North Carolina there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • When did momondo last update prices for flights from North Carolina to Panama?

    Prices for flights from North Carolina to Panama refresh daily.

  • How many operators does momondo search for flights from North Carolina to Panama?

  • How old do you have to be to fly from North Carolina to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from North Carolina to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from North Carolina to Panama?

Best airlines flying from North Carolina to Panama

Compare and see reviews for airlines that fly from North Carolina to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $249Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $352Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
DeltaPriceFrom $367Free CancellationRating
7.9
8,014 reviews
Search Delta flights
United AirlinesPriceFrom $409Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from North Carolina to Panama for you.

Can I find flights from North Carolina to Panama with flexible booking policies on momondo?

Flights from North Carolina to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from North Carolina to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from North Carolina.

I’m not ready to book a flight from North Carolina to Panama right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of North Carolina to Panama flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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