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Cheap flights from Missouri to Santiago from $303

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santiago departing on 1/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:56 pm - 8:15 am
MCI
-
SCL
15h 19m1 stop
American Airlines Logo
10:30 pm - 10:35 am
SCL
-
MCI
15h 05m1 stop
$756American Airlines
Mon, Jan 19 - Mon, Feb 2
United Airlines Logo
7:40 am - 7:50 am
STL
-
SCL
22h 10m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$757United Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
10:00 am - 7:50 am
STL
-
SCL
19h 50m2 stops
United Airlines Logo
9:45 pm - 9:21 am
SCL
-
STL
13h 36m1 stop
$758United Airlines
Wed, Mar 11 - Mon, Mar 23
Delta Logo
12:01 pm - 3:30 pm
SGF
-
SCL
24h 29m2 stops
Delta Logo
6:30 pm - 4:15 pm
SCL
-
SGF
24h 45m2 stops
$764Delta
Wed, Jan 14 - Wed, Jan 28
LATAM Airlines Logo
12:04 pm - 7:40 am
STL
-
SCL
17h 36m1 stop
LATAM Airlines Logo
10:10 pm - 5:53 pm
SCL
-
STL
21h 43m1 stop
$764LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
United Airlines Logo
3:00 pm - 8:50 am
MCI
-
SCL
14h 50m1 stop
United Airlines Logo
10:45 pm - 4:53 pm
SCL
-
MCI
21h 08m1 stop
$764United Airlines
Mon, Jan 12 - Wed, Feb 4
LATAM Airlines Logo
5:21 pm - 5:55 pm
STL
-
SCL
22h 34m2 stops
LATAM Airlines Logo
6:30 pm - 5:53 pm
SCL
-
STL
25h 23m2 stops
$766LATAM Airlines
Wed, Mar 11 - Mon, Mar 23
Delta Logo
6:23 pm - 7:40 am
MCI
-
SCL
34h 17m1 stop
Delta Logo
11:10 pm - 12:17 pm
SCL
-
MCI
16h 07m1 stop
$773Delta
Sun, Jan 18 - Tue, Feb 3
Multiple Airlines Logo
12:14 pm - 6:45 am
STL
-
SCL
64h 31m3 stops
Multiple Airlines Logo
4:35 am - 10:31 am
SCL
-
STL
31h 56m3 stops
$875Multiple Airlines
Wed, Mar 11 - Mon, Mar 23
Multiple Airlines Logo
8:12 pm - 6:45 am
STL
-
SCL
32h 33m3 stops
Multiple Airlines Logo
4:35 am - 10:31 am
SCL
-
STL
31h 56m3 stops
$879Multiple Airlines
Wed, Mar 11 - Mon, Mar 23

American Airlines flights from Missouri to Santiago

Our best American Airlines deals on Missouri to Santiago flight tickets
American Airlines
Jan 19
MCI1:56 pmKansas City
15h 19m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Feb 2
SCL10:30 pmSantiago Arturo Merino Benitez
15h 05m
1 stop
MCI10:35 amKansas City
$756
Find similar
American Airlines
Jan 31
MCI11:34 amKansas City
17h 41m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Mar 6
SCL10:00 pmSantiago Arturo Merino Benitez
15h 20m
1 stop
MCI10:20 amKansas City
$844
Find similar
American Airlines
Apr 13
STL12:03 pmLambert-St Louis
18h 02m
2 stops
SCL7:05 amSantiago Arturo Merino Benitez
Apr 24
SCL8:50 pmSantiago Arturo Merino Benitez
21h 23m
2 stops
STL5:13 pmLambert-St Louis
$884
Find similar

LATAM Airlines flights from Missouri to Santiago

Our best LATAM Airlines deals on Missouri to Santiago flight tickets
LATAM Airlines
Mar 11
STL12:04 pmLambert-St Louis
17h 36m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 23
SCL10:10 pmSantiago Arturo Merino Benitez
21h 43m
1 stop
STL5:53 pmLambert-St Louis
$764
Find similar
LATAM Airlines
Mar 11
STL5:21 pmLambert-St Louis
22h 34m
2 stops
SCL5:55 pmSantiago Arturo Merino Benitez
Mar 23
SCL6:30 pmSantiago Arturo Merino Benitez
25h 23m
2 stops
STL5:53 pmLambert-St Louis
$766
Find similar
LATAM Airlines
Mar 11
STL6:59 pmLambert-St Louis
20h 31m
2 stops
SCL5:30 pmSantiago Arturo Merino Benitez
Mar 23
SCL6:40 amSantiago Arturo Merino Benitez
19h 18m
2 stops
STL11:58 pmLambert-St Louis
$767
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 1/19

1:56 pm-8:15 am

1 stop15h 19m

Santiago Arturo Merino Benitez

Mon 2/2

10:30 pm-10:35 am

1 stop15h 05m

$756

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

7:40 am-7:50 am

2 stops22h 10m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$757

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

10:00 am-7:50 am

2 stops19h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$758

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

12:01 pm-3:30 pm

2 stops24h 29m

Santiago Arturo Merino Benitez

Wed 1/28

6:30 pm-4:15 pm

2 stops24h 45m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:04 pm-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 3/23

10:10 pm-5:53 pm

1 stop21h 43m

$764

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 1/12

3:00 pm-8:50 am

1 stop14h 50m

Santiago Arturo Merino Benitez

Wed 2/4

10:45 pm-4:53 pm

1 stop21h 08m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

5:21 pm-5:55 pm

2 stops22h 34m

Santiago Arturo Merino Benitez

Mon 3/23

6:30 pm-5:53 pm

2 stops25h 23m

$766

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Sun 1/18

6:23 pm-7:40 am

1 stop34h 17m

Santiago Arturo Merino Benitez

Tue 2/3

11:10 pm-12:17 pm

1 stop16h 07m

$773

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:14 pm-6:45 am

3 stops64h 31m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-10:31 am

3 stops31h 56m

$875

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

8:12 pm-6:45 am

3 stops32h 33m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-10:31 am

3 stops31h 56m

$879

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Missouri to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from Missouri to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $876. If you don’t want to visit Santiago in March, then you should wait until July to fly from Missouri, when ticket prices are also cheap, with an average price of $883.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $955. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,189.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Missouri to Santiago when you can find flight prices for as low as $982. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,074 per ticket.

Cheap Missouri to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santiago

Fastest flight time

12h 28m

Direct flights

None
The fastest flight from Missouri to Santiago takes 12h 28m
There are no direct flights from Missouri to Santiago. There are no popular flight routes from Missouri to Santiago.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Missouri to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Missouri to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santiago

Compare and see reviews for airlines that fly from Missouri to Santiago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $689Free CancellationRating
7.2
11,065 reviews
Search American Airlines flights
DeltaPriceFrom $755Free CancellationRating
7.9
8,014 reviews
Search Delta flights
LATAM AirlinesPriceFrom $823Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from Missouri.

Can I find flights from Missouri to Santiago with flexible booking policies on momondo?

Flights from Missouri to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Missouri to Santiago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Missouri to Santiago.

I’m not ready to book a flight from Missouri to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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