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Cheap flights from Missouri to the Cayman Islands from $337

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to the Cayman Islands departing on 1/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:10 am - 2:40 pmSTL-GCM
7h 30m1 stop
Delta Logo
2:05 pm - 11:39 pmGCM-STL
10h 34m1 stop
$337Delta
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Fri, Jan 23 - Tue, Feb 3
Delta Logo
6:00 am - 12:40 pmSTL-GCM
5h 40m1 stop
Delta Logo
3:45 pm - 11:25 pmGCM-STL
8h 40m1 stop
$346Delta
Find Deal
Sat, Jan 31 - Fri, Feb 20
Delta Logo
5:56 pm - 12:50 pmSTL-GCM
17h 54m2 stops
Delta Logo
2:05 pm - 11:39 pmGCM-STL
10h 34m1 stop
$351Delta
Find Deal
Fri, Jan 23 - Mon, Feb 2
American Airlines Logo
5:20 pm - 11:50 amSTL-GCM
17h 30m2 stops
American Airlines Logo
3:30 pm - 10:21 amGCM-STL
19h 51m1 stop
$357American Airlines
Find Deal
Sun, Jan 18 - Fri, Jan 23
American Airlines Logo
6:44 pm - 2:35 pmSTL-GCM
18h 51m1 stop
American Airlines Logo
3:30 pm - 10:21 amGCM-STL
19h 51m1 stop
$358American Airlines
Find Deal
Sun, Jan 18 - Fri, Jan 23
American Airlines Logo
5:20 pm - 11:50 amSTL-GCM
17h 30m2 stops
American Airlines Logo
8:45 am - 9:51 pmGCM-STL
14h 06m2 stops
$380American Airlines
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Sun, Jan 25 - Fri, Jan 30
Spirit Airlines Logo
4:28 pm - 1:39 pmMCI-GCM
20h 11m2 stops
Spirit Airlines Logo
2:49 pm - 10:31 amGCM-MCI
20h 42m1 stop
$381Spirit Airlines
Find Deal
Sat, Jan 24 - Thu, Jan 29
American Airlines Logo
6:00 am - 8:25 pmSTL-GCM
13h 25m2 stops
American Airlines Logo
8:45 am - 9:51 pmGCM-STL
14h 06m2 stops
$381American Airlines
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Mon, Feb 2 - Mon, Feb 9
Spirit Airlines Logo
4:28 pm - 1:53 pmMCI-GCM
20h 25m2 stops
Spirit Airlines Logo
2:49 pm - 3:33 pmGCM-MCI
25h 44m3 stops
$419Spirit Airlines
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Sat, Jan 24 - Thu, Jan 29
Southwest Logo
7:20 pm - 12:55 pmMCI-GCM
16h 35m2 stops
Southwest Logo
1:50 pm - 10:20 pmGCM-MCI
9h 30m2 stops
$460Southwest
Find Deal
Sun, Feb 22 - Wed, Feb 25

Southwest flights from Missouri to Cayman Islands

Our best Southwest deals on Missouri to Cayman Islands flight tickets
Southwest
Mar 8
STL9:35 pmLambert-St Louis
14h 05m
2 stops
GCM11:40 amGeorge Town Owen Roberts Intl
Mar 11
GCM12:35 pmGeorge Town Owen Roberts Intl
10h 30m
1 stop
STL11:05 pmLambert-St Louis
$411
Find similar
Southwest
Feb 22
MCI7:20 pmKansas City
16h 35m
2 stops
GCM12:55 pmGeorge Town Owen Roberts Intl
Feb 25
GCM1:50 pmGeorge Town Owen Roberts Intl
9h 30m
2 stops
MCI10:20 pmKansas City
$460
Find similar
Southwest
Jan 26
STL7:55 pmLambert-St Louis
16h 00m
2 stops
GCM12:55 pmGeorge Town Owen Roberts Intl
Jan 31
GCM1:25 pmGeorge Town Owen Roberts Intl
7h 45m
2 stops
STL8:10 pmLambert-St Louis
$661
Find similar

Delta flights from Missouri to Cayman Islands

Our best Delta deals on Missouri to Cayman Islands flight tickets
Delta
Jan 23
STL5:56 pmLambert-St Louis
16h 23m
1 stop
GCM11:19 amGeorge Town Owen Roberts Intl
Jan 29
GCM2:05 pmGeorge Town Owen Roberts Intl
7h 34m
1 stop
STL8:39 pmLambert-St Louis
$337
Find similar
Delta
Jan 31
STL7:10 amLambert-St Louis
5h 50m
1 stop
GCM2:00 pmGeorge Town Owen Roberts Intl
Feb 9
GCM2:05 pmGeorge Town Owen Roberts Intl
10h 34m
1 stop
STL11:39 pmLambert-St Louis
$346
Find similar
Delta
Jan 23
STL5:56 pmLambert-St Louis
17h 54m
2 stops
GCM12:50 pmGeorge Town Owen Roberts Intl
Feb 2
GCM2:05 pmGeorge Town Owen Roberts Intl
10h 34m
1 stop
STL11:39 pmLambert-St Louis
$351
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

6:10 am-2:40 pm

1 stop7h 30m

George Town Owen Roberts Intl

Tue 2/3

2:05 pm-11:39 pm

1 stop10h 34m

$337

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 1/31

6:00 am-12:40 pm

1 stop5h 40m

George Town Owen Roberts Intl

Fri 2/20

3:45 pm-11:25 pm

1 stop8h 40m

$346

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Fri 1/23

5:56 pm-12:50 pm

2 stops17h 54m

George Town Owen Roberts Intl

Mon 2/2

2:05 pm-11:39 pm

1 stop10h 34m

$351

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sun 1/18

5:20 pm-11:50 am

2 stops17h 30m

George Town Owen Roberts Intl

Fri 1/23

3:30 pm-10:21 am

1 stop19h 51m

$357

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sun 1/18

6:44 pm-2:35 pm

1 stop18h 51m

George Town Owen Roberts Intl

Fri 1/23

3:30 pm-10:21 am

1 stop19h 51m

$358

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sun 1/25

5:20 pm-11:50 am

2 stops17h 30m

George Town Owen Roberts Intl

Fri 1/30

8:45 am-9:51 pm

2 stops14h 06m

$380

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 1/24

4:28 pm-1:39 pm

2 stops20h 11m

George Town Owen Roberts Intl

Thu 1/29

2:49 pm-10:31 am

1 stop20h 42m

$381

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Mon 2/2

6:00 am-8:25 pm

2 stops13h 25m

George Town Owen Roberts Intl

Mon 2/9

8:45 am-9:51 pm

2 stops14h 06m

$381

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 1/24

4:28 pm-1:53 pm

2 stops20h 25m

George Town Owen Roberts Intl

Thu 1/29

2:49 pm-3:33 pm

3 stops25h 44m

$419

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 2/22

7:20 pm-12:55 pm

2 stops16h 35m

George Town Owen Roberts Intl

Wed 2/25

1:50 pm-10:20 pm

2 stops9h 30m

$460

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Missouri to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of September, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $536.

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Wednesday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $492. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $665.

How far in advance should I book a flight to Cayman Islands?

You are more likely to see cheaper flights to Cayman Islands from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Cayman Islands for around $614 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cayman Islands from Missouri for as low as $510 on momondo.

Cheap Missouri to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Cayman Islands

Direct flights

None
There are no direct flights from Missouri to Cayman Islands. There are no popular flight routes from Missouri to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Cayman Islands?

    Prices for flights from Missouri to Cayman Islands were last updated today.

  • How many operators does momondo search for flights from Missouri to Cayman Islands?

  • How old do you have to be to fly from Missouri to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Missouri to Cayman Islands

Compare and see reviews for airlines that fly from Missouri to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $238Free CancellationRating
7.4
9,017 reviews
Search United Airlines flights
DeltaPriceFrom $266Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $424Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
SouthwestPriceFrom $429Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Cayman Islands?

Finding the right flight to Cayman Islands from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Cayman Islands quick and easy, saving you time and money.

Can I find flights from Missouri to Cayman Islands with flexible booking policies on momondo?

All flight searches from Missouri to Cayman Islands on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Missouri to Cayman Islands?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Missouri to Cayman Islands.

I’m not ready to book a flight from Missouri to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missouri to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

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