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Cheap flights from Chicago Midway Airport to Panama City from $371

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Panama City departing on 10/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Chicago Midway Airport to Panama City (MDW-PTY)

Cheap round-trip flights

Logo
6:20 am - 7:33 pmMDW-PTY
13h 13m1 stop
Logo
9:25 am - 11:20 pmPTY-MDW
13h 55m1 stop
$574
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Thu, Sep 18 - Sun, Sep 21
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
8:05 am - 3:30 pmPTY-MDW
8h 25m1 stop
$587Delta
Find Deal
Tue, Nov 25 - Sat, Dec 6
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
3:17 pm - 8:45 amPTY-MDW
18h 28m2 stops
$592Delta
Find Deal
Tue, Nov 25 - Thu, Dec 4
Delta Logo
6:00 am - 7:59 pmMDW-PTY
12h 59m1 stop
Delta Logo
3:37 pm - 11:32 pmPTY-MDW
8h 55m1 stop
$596Delta
Find Deal
Sat, Nov 22 - Thu, Nov 27
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
Delta Logo
3:17 pm - 4:23 pmPTY-MDW
26h 06m1 stop
$597Delta
Find Deal
Tue, Nov 25 - Thu, Dec 4
Delta Logo
5:34 pm - 2:12 pmMDW-PTY
19h 38m1 stop
Delta Logo
3:17 pm - 12:32 pmPTY-MDW
22h 15m2 stops
$601Delta
Find Deal
Thu, Nov 27 - Fri, Dec 5
Logo
6:20 am - 7:33 pmMDW-PTY
13h 13m1 stop
Logo
9:25 am - 11:46 pmPTY-MDW
14h 21m1 stop
$648
Find Deal
Thu, Oct 23 - Sun, Oct 26
Logo
11:49 am - 7:28 pmMDW-PTY
7h 39m1 stop
Logo
6:01 pm - 9:47 amPTY-MDW
15h 46m1 stop
$660
Find Deal
Thu, Oct 16 - Wed, Oct 22
Logo
6:15 am - 7:33 pmMDW-PTY
13h 18m1 stop
Logo
9:25 am - 10:47 pmPTY-MDW
13h 22m1 stop
$720
Find Deal
Sat, Oct 11 - Sat, Oct 18
Logo
6:20 am - 7:33 pmMDW-PTY
13h 13m1 stop
Logo
11:00 am - 8:39 amPTY-MDW
21h 39m2 stops
$747
Find Deal
Thu, Oct 16 - Wed, Oct 22

Delta flights from Chicago Midway Airport to Panama City

Our best Delta deals on Chicago Midway Airport to Panama City flight tickets
Delta
Nov 25
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Dec 6
PTY8:05 amPanama City Tocumen Intl
8h 25m
1 stop
MDW3:30 pmChicago Midway
$587
Find similar
Delta
Nov 25
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Dec 4
PTY3:17 pmPanama City Tocumen Intl
18h 28m
2 stops
MDW8:45 amChicago Midway
$592
Find similar
Delta
Nov 22
MDW6:00 amChicago Midway
12h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Nov 27
PTY3:37 pmPanama City Tocumen Intl
8h 55m
1 stop
MDW11:32 pmChicago Midway
$596
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Chicago Midway Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 9/18

6:20 am-7:33 pm

1 stop13h 13m

Panama City Tocumen Intl

Sun 9/21

9:25 am-11:20 pm

1 stop13h 55m

$574

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 11/25

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Sat 12/6

8:05 am-3:30 pm

1 stop8h 25m

$587

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 11/25

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Thu 12/4

3:17 pm-8:45 am

2 stops18h 28m

$592

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 11/22

6:00 am-7:59 pm

1 stop12h 59m

Panama City Tocumen Intl

Thu 11/27

3:37 pm-11:32 pm

1 stop8h 55m

$596

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 11/25

6:00 am-2:12 pm

1 stop7h 12m

Panama City Tocumen Intl

Thu 12/4

3:17 pm-4:23 pm

1 stop26h 06m

$597

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 11/27

5:34 pm-2:12 pm

1 stop19h 38m

Panama City Tocumen Intl

Fri 12/5

3:17 pm-12:32 pm

2 stops22h 15m

$601

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 10/23

6:20 am-7:33 pm

1 stop13h 13m

Panama City Tocumen Intl

Sun 10/26

9:25 am-11:46 pm

1 stop14h 21m

$648

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 10/16

11:49 am-7:28 pm

1 stop7h 39m

Panama City Tocumen Intl

Wed 10/22

6:01 pm-9:47 am

1 stop15h 46m

$660

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 10/11

6:15 am-7:33 pm

1 stop13h 18m

Panama City Tocumen Intl

Sat 10/18

9:25 am-10:47 pm

1 stop13h 22m

$720

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 10/16

6:20 am-7:33 pm

1 stop13h 13m

Panama City Tocumen Intl

Wed 10/22

11:00 am-8:39 am

2 stops21h 39m

$747

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Chicago Midway Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $540. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $614. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Chicago Midway Airport to Panama City during this time can be as low as $510. Try not to purchase tickets at noon because they tend to be around $610. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Chicago Midway Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Panama City (MDW to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Panama City

Direct flights

None
There are no direct flights from Chicago Midway Airport to Panama City. There are no popular flight routes from Chicago Midway Airport to Panama City.
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  • How far is Chicago Midway to Panama City Tocumen Intl by plane?

    Chicago Midway and Panama City Tocumen Intl are 2319.5 mi apart from one another. By plane, this route typically takes 6h 52m.

  • When did momondo last update prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Chicago to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Chicago to Panama City with flexible booking policies on momondo?

Flights from Chicago to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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