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Cheap flights from Chicago Midway Airport to Panama City from $378

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Panama City departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Chicago Midway Airport to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:05 am - 12:35 am
MDW
-
PTY
18h 30m
3 stops
Multiple Airlines Logo
5:30 am - 10:47 pm
PTY
-
MDW
17h 17m
3 stops
$684Multiple Airlines
Thu, Aug 20 - Tue, Aug 25
Delta Logo
12:46 pm - 12:55 pm
MDW
-
PTY
24h 09m
1 stop
Delta Logo
2:20 pm - 10:36 pm
PTY
-
MDW
8h 16m
1 stop
$751Delta
Thu, Aug 27 - Wed, Sep 2
Delta Logo
6:00 am - 12:56 pm
MDW
-
PTY
6h 56m
1 stop
Delta Logo
2:21 pm - 10:25 pm
PTY
-
MDW
8h 04m
1 stop
$752Delta
Fri, Oct 16 - Sun, Oct 18
Delta Logo
6:45 pm - 12:56 pm
MDW
-
PTY
18h 11m
2 stops
Delta Logo
2:21 pm - 10:25 pm
PTY
-
MDW
8h 04m
1 stop
$756Delta
Sun, Oct 11 - Sun, Oct 18
Multiple Airlines Logo
12:03 pm - 8:34 pm
MDW
-
PTY
8h 31m
1 stop
Multiple Airlines Logo
10:26 am - 9:58 pm
PTY
-
MDW
11h 32m
1 stop
$757Multiple Airlines
Thu, Sep 17 - Sun, Sep 20
Multiple Airlines Logo
12:03 pm - 8:34 pm
MDW
-
PTY
8h 31m
1 stop
Multiple Airlines Logo
10:00 am - 9:58 pm
PTY
-
MDW
11h 58m
1 stop
$758Multiple Airlines
Mon, Sep 28 - Thu, Oct 1
Delta Logo
6:05 am - 12:55 pm
MDW
-
PTY
6h 50m
1 stop
Delta Logo
2:23 pm - 10:45 pm
PTY
-
MDW
8h 22m
1 stop
$760Delta
Tue, Sep 1 - Wed, Sep 30
Delta Logo
6:00 am - 12:56 pm
MDW
-
PTY
6h 56m
1 stop
Delta Logo
2:21 pm - 9:52 am
PTY
-
MDW
19h 31m
1 stop
$763Delta
Mon, Oct 12 - Mon, Oct 19
Delta Logo
5:45 pm - 12:55 pm
MDW
-
PTY
19h 10m
2 stops
Delta Logo
2:23 pm - 9:07 am
PTY
-
MDW
18h 44m
2 stops
$764Delta
Sat, Sep 5 - Thu, Sep 10
Delta Logo
5:10 pm - 1:05 pm
MDW
-
PTY
19h 55m
1 stop
Delta Logo
2:23 pm - 10:45 pm
PTY
-
MDW
8h 22m
1 stop
$771Delta
Fri, Sep 4 - Thu, Sep 10

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Delta flights from Chicago Midway Airport to Panama City

Our best Delta deals on Chicago Midway Airport to Panama City flight tickets
Delta
Aug 27
MDW12:46 pmChicago Midway
24h 09m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 2
PTY2:20 pmPanama City Tocumen Intl
8h 16m
1 stop
MDW10:36 pmChicago Midway
$751
Delta
Oct 16
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 18
PTY2:21 pmPanama City Tocumen Intl
8h 04m
1 stop
MDW10:25 pmChicago Midway
$752
Delta
Oct 11
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 19
PTY2:21 pmPanama City Tocumen Intl
22h 27m
2 stops
MDW12:48 pmChicago Midway
$756

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 7, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 8/20

6:05 am-12:35 am

3 stops18h 30m

Panama City Tocumen Intl

Tue 8/25

5:30 am-10:47 pm

3 stops17h 17m

$684

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 8/27

12:46 pm-12:55 pm

1 stop24h 09m

Panama City Tocumen Intl

Wed 9/2

2:20 pm-10:36 pm

1 stop8h 16m

$751
Quickest round-trip

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Fri 10/16

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Sun 10/18

2:21 pm-10:25 pm

1 stop8h 04m

$752

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sun 10/11

6:45 pm-12:56 pm

2 stops18h 11m

Panama City Tocumen Intl

Sun 10/18

2:21 pm-10:25 pm

1 stop8h 04m

$756

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Thu 9/17

12:03 pm-8:34 pm

1 stop8h 31m

Panama City Tocumen Intl

Sun 9/20

10:26 am-9:58 pm

1 stop11h 32m

$757

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Mon 9/28

12:03 pm-8:34 pm

1 stop8h 31m

Panama City Tocumen Intl

Thu 10/1

10:00 am-9:58 pm

1 stop11h 58m

$758

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 9/1

6:05 am-12:55 pm

1 stop6h 50m

Panama City Tocumen Intl

Wed 9/30

2:23 pm-10:45 pm

1 stop8h 22m

$760

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Mon 10/12

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Mon 10/19

2:21 pm-9:52 am

1 stop19h 31m

$763

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Sat 9/5

5:45 pm-12:55 pm

2 stops19h 10m

Panama City Tocumen Intl

Thu 9/10

2:23 pm-9:07 am

2 stops18h 44m

$764

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Fri 9/4

5:10 pm-1:05 pm

1 stop19h 55m

Panama City Tocumen Intl

Thu 9/10

2:23 pm-10:45 pm

1 stop8h 22m

$771

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Chicago Midway Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $555. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $598. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Chicago Midway Airport to Panama City during this time can be as low as $482. Try not to purchase tickets in the morning because they tend to be around $588. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Chicago Midway Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Panama City (MDW to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Panama City

Fastest flight time

6h 50m

Direct flights

None
The fastest flight from Chicago Midway Airport to Panama City takes 6h 50m
There are no direct flights from Chicago Midway Airport to Panama City. There are no popular flight routes from Chicago Midway Airport to Panama City.
Search flight deals

Frequently asked questions about flying from Chicago Midway Airport to Panama City

  • How far is Chicago Midway to Panama City Tocumen Intl by plane?

    Chicago Midway and Panama City Tocumen Intl are 2319.5 mi apart from one another. By plane, this route typically takes 6h 50m.

  • When did momondo last update prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Chicago to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Chicago to Panama City with flexible booking policies on momondo?

Flights from Chicago to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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