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Cheap flights from Chicago Midway Airport to Panama City from $337

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Panama City departing on 10/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Chicago Midway Airport to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:05 am - 9:15 amMDW  Chicago Midway-PTY Panama City Tocumen Intl
27h 10m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado
Multiple Airlines Logo
3:10 pm - 10:47 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
31h 37m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson
$680Multiple Airlines
Wed, Sep 2 - Mon, Sep 7
Multiple Airlines Logo
6:05 am - 9:15 amMDW  Chicago Midway-PTY Panama City Tocumen Intl
27h 10m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado
Multiple Airlines Logo
4:25 am - 10:47 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
18h 22m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson
$692Multiple Airlines
Tue, Sep 1 - Tue, Sep 8
Multiple Airlines Logo
6:25 am - 8:37 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
14h 12m2 stops Atlanta Hartsfield-Jackson Miami
Multiple Airlines Logo
8:01 am - 11:44 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
15h 43m2 stops Miami Atlanta Hartsfield-Jackson
$728Multiple Airlines
Thu, Sep 17 - Thu, Sep 24
Multiple Airlines Logo
6:25 am - 8:37 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
14h 12m2 stops Atlanta Hartsfield-Jackson Miami
Multiple Airlines Logo
8:01 am - 11:44 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
15h 43m2 stops Miami Atlanta Hartsfield-Jackson
$731Multiple Airlines
Thu, Sep 17 - Thu, Sep 24
Multiple Airlines Logo
6:05 am - 12:35 amMDW  Chicago Midway-PTY Panama City Tocumen Intl
18h 30m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado
Multiple Airlines Logo
5:30 am - 10:47 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
17h 17m3 stops San Salvador El Salvador Intl Miami Atlanta Hartsfield-Jackson
$746Multiple Airlines
Wed, Aug 19 - Wed, Aug 26
Multiple Airlines Logo
6:25 am - 8:37 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
14h 12m2 stops Atlanta Hartsfield-Jackson Miami
Multiple Airlines Logo
6:34 pm - 11:44 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
29h 10m2 stops Miami Atlanta Hartsfield-Jackson
$788Multiple Airlines
Sun, Sep 20 - Wed, Sep 23
Multiple Airlines Logo
6:25 am - 8:37 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
14h 12m2 stops Atlanta Hartsfield-Jackson Miami
Multiple Airlines Logo
9:33 pm - 11:44 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
26h 11m2 stops Miami Atlanta Hartsfield-Jackson
$788Multiple Airlines
Sun, Sep 20 - Wed, Sep 23
Multiple Airlines Logo
6:05 am - 12:35 amMDW  Chicago Midway-PTY Panama City Tocumen Intl
18h 30m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado
Multiple Airlines Logo
5:30 am - 10:47 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
17h 17m3 stops San Salvador El Salvador Intl Miami Atlanta Hartsfield-Jackson
$791Multiple Airlines
Tue, Aug 18 - Tue, Aug 25
Delta Logo
6:04 am - 1:59 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
6h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 10:56 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
8h 26m1 stop Atlanta Hartsfield-Jackson
$792Delta
Sat, Nov 7 - Wed, Nov 11
Delta Logo
6:00 am - 2:05 pmMDW  Chicago Midway-PTY Panama City Tocumen Intl
7h 05m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 10:56 pmPTY  Panama City Tocumen Intl-MDW Chicago Midway
8h 26m1 stop Atlanta Hartsfield-Jackson
$792Delta
Wed, Nov 18 - Wed, Dec 9

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Delta flights from Chicago Midway Airport to Panama City

Our best Delta deals on Chicago Midway Airport to Panama City flight tickets
Delta
Nov 18
MDW6:00 amChicago Midway
7h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
Dec 9
PTY3:30 pmPanama City Tocumen Intl
8h 26m
1 stop
MDW10:56 pmChicago Midway
$792
Delta
Oct 23
MDW6:04 amChicago Midway
6h 55m
1 stop
PTY12:59 pmPanama City Tocumen Intl
Oct 27
PTY2:24 pmPanama City Tocumen Intl
8h 09m
1 stop
MDW10:33 pmChicago Midway
$794
Delta
Sep 24
MDW6:05 amChicago Midway
6h 53m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 29
PTY2:23 pmPanama City Tocumen Intl
8h 21m
1 stop
MDW10:44 pmChicago Midway
$800

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Wed 9/2

6:05 am-9:15 am

3 stops27h 10m

Panama City Tocumen Intl

Mon 9/7

3:10 pm-10:47 pm

3 stops31h 37m

$680

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Tue 9/1

6:05 am-9:15 am

3 stops27h 10m

Panama City Tocumen Intl

Tue 9/8

4:25 am-10:47 pm

3 stops18h 22m

$692

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Thu 9/17

6:25 am-8:37 pm

2 stops14h 12m

Panama City Tocumen Intl

Thu 9/24

8:01 am-11:44 pm

2 stops15h 43m

$728

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Thu 9/17

6:25 am-8:37 pm

2 stops14h 12m

Panama City Tocumen Intl

Thu 9/24

8:01 am-11:44 pm

2 stops15h 43m

$731

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Wed 8/19

6:05 am-12:35 am

3 stops18h 30m

Panama City Tocumen Intl

Wed 8/26

5:30 am-10:47 pm

3 stops17h 17m

$746

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Sun 9/20

6:25 am-8:37 pm

2 stops14h 12m

Panama City Tocumen Intl

Wed 9/23

6:34 pm-11:44 pm

2 stops29h 10m

$788

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Sun 9/20

6:25 am-8:37 pm

2 stops14h 12m

Panama City Tocumen Intl

Wed 9/23

9:33 pm-11:44 pm

2 stops26h 11m

$788

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Tue 8/18

6:05 am-12:35 am

3 stops18h 30m

Panama City Tocumen Intl

Tue 8/25

5:30 am-10:47 pm

3 stops17h 17m

$791
Quickest round-trip

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Sat 11/7

6:04 am-1:59 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 11/11

3:30 pm-10:56 pm

1 stop8h 26m

$792

ChicagoPanama City

MDW Chicago Midway - PTY Panama City Tocumen Intl

MDWPTY

Chicago Midway

Wed 11/18

6:00 am-2:05 pm

1 stop7h 05m

Panama City Tocumen Intl

Wed 12/9

3:30 pm-10:56 pm

1 stop8h 26m

$792

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Chicago Midway Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $560. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Chicago Midway Airport to Panama City during this time can be as low as $482. Try not to purchase tickets in the morning because they tend to be around $591. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Chicago Midway Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Panama City (MDW to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Panama City

Fastest flight time

6h 55m

Direct flights

None
The fastest flight from Chicago Midway Airport to Panama City takes 6h 55m
There are no direct flights from Chicago Midway Airport to Panama City. There are no popular flight routes from Chicago Midway Airport to Panama City.
Search flight deals

Frequently asked questions about flying from Chicago Midway Airport to Panama City

  • How far is Chicago Midway to Panama City Tocumen Intl by plane?

    Chicago Midway and Panama City Tocumen Intl are 2319.5 mi apart from one another. By plane, this route typically takes 6h 55m.

  • When did momondo last update prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Chicago Midway Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago Midway Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Chicago to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Chicago to Panama City with flexible booking policies on momondo?

Flights from Chicago to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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