Cheap flights from Maryland to Panama City from $281

In general, April is the cheapest month to fly from Maryland to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $565. If you’re not able to fly to Panama City in April, then September is your next best option. Flight prices from Maryland to Panama City during September average around $598.

Our data shows that Monday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $552. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $616. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Maryland to Panama City during this time can be as low as $522. Try not to purchase tickets in the morning because they tend to be around $648. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Baltimore/Washington to Panama City Tocumen Intl for the best Maryland - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Maryland when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $628 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Maryland for as low as $503 on momondo.

There are 3 cabin classes available to choose from on Maryland to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines is the most popular carrier operating from Maryland to Panama City Tocumen Intl

Copa Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama City from Maryland according to our data. Copa Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

As of September 2026, there are 1 flights per day flying from Maryland to Panama City. The most common time of day flights depart is 4:00PM, with 100% of flights taking off in the afternoon.

As of September 2026, 8 flights take off from Maryland and land in Panama City each week. The most common flight departure day for this route is Wed, with 25% of weekly flights taking off on this day.