Cheap flights from Madrid to Santo Domingo from $336

If you don’t want to visit Santo Domingo in September, then you should wait until October to fly from Madrid, when ticket prices are also cheap, with an average price of $748.

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $851. The most expensive day to fly to Santo Domingo is Wednesday, with ticket prices averaging around $984.

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $864. Try not to purchase tickets in the morning because they tend to be around $1,023. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Madrid Barajas to Santo Domingo Las Americas for the best Madrid Barajas - Santo Domingo Las Americas flight prices

You are more likely to see cheaper flights to Santo Domingo from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santo Domingo for around $890 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santo Domingo from Madrid for as low as $846 on momondo.

There are 3 cabin classes available to choose from on Madrid to Santo Domingo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Iberia, Air Europa, and JetBlue are the most popular carriers operating from Madrid Barajas to Santo Domingo Las Americas

Iberia, Air Europa and World2Fly are the top three most popular airlines that fly to Santo Domingo from Madrid according to our data. Iberia is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Santo Domingo. Keep in mind that there are 3 different airlines that fly to Santo Domingo on a routine basis, so you have a few additional options to choose from.

Historically, on average around 27% of flights between Madrid and Santo Domingo have experienced a delay on any given week. The average delay length over the past 12 months has been 136 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Air Europa have had the least number of delays on this route over the last 12 months; with about 23% of their flights experiencing any sort of delay.

As of September 2026, 5 flights take off from Madrid and land in Santo Domingo each day. The most common flight departure time for this route is 11:00AM, with 56% of daily flights taking off in the afternoon.

As of September 2026, there are 38 flights per week flying from Madrid to Santo Domingo. The most common day of the week flights depart is Fri, with 32% of flights taking off on this day.